locus-tag	class	description
E4664_00100	COG4695	Portal protein
E4664_00120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4664_00140	COG0726	polysaccharide deacetylase
E4664_00145	COG0463	Glycosyl transferase, family 2
E4664_00150	COG0438	transferase activity, transferring glycosyl groups
E4664_00165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4664_00215	COG1960	acyl-CoA dehydrogenase activity
E4664_00220	COG1960	acyl-CoA dehydrogenase activity
E4664_00230	COG2205	protein histidine kinase activity
E4664_00235	COG0745	RESPONSE REGULATOR receiver
E4664_00240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4664_00255	COG0584	glycerophosphoryl diester phosphodiesterase
E4664_00260	COG2096	Adenosyltransferase
E4664_00265	COG4206	TonB-dependent receptor
E4664_00275	COG0133	tryptophan synthase activity
E4664_00310	COG0285	dihydrofolate synthase activity
E4664_00330	COG0450	alkyl hydroperoxide reductase
E4664_00345	COG0477	Major facilitator Superfamily
E4664_00350	COG1272	protein, Hemolysin III
E4664_00380	COG0183	Belongs to the thiolase family
E4664_00385	COG2207	Transcriptional regulator
E4664_00405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4664_00425	COG0183	Belongs to the thiolase family
E4664_00435	COG2885	chlorophyll binding
E4664_00435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4664_00440	COG1690	Belongs to the RtcB family
E4664_00445	COG0833	amino acid
E4664_00455	COG2233	PERMEase
E4664_00485	COG2094	Belongs to the DNA glycosylase MPG family
E4664_00490	COG4772	TonB-dependent receptor
E4664_00495	COG1902	pentaerythritol trinitrate reductase activity
E4664_00500	COG0679	Auxin Efflux Carrier
E4664_00510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4664_00515	COG0354	folic acid binding
E4664_00530	COG3189	MarR family transcriptional regulator
E4664_00535	COG2824	Alkylphosphonate utilization operon protein PhnA
E4664_00540	COG3422	double-strand break repair
E4664_00580	COG0840	transmembrane signaling receptor activity
E4664_00600	COG5510	response to toxic substance
E4664_00610	COG2832	Protein of unknown function (DUF454)
E4664_00615	COG1376	ErfK ybiS ycfS ynhG family protein
E4664_00665	COG1289	transmembrane transporter activity
E4664_00670	COG2814	Major facilitator Superfamily
E4664_00690	COG1115	amino acid carrier protein
E4664_00695	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4664_00700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4664_00705	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4664_00710	COG3590	peptidase
E4664_00735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4664_00745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4664_00750	COG1077	Cell shape determining protein MreB Mrl
E4664_00755	COG1792	Involved in formation and maintenance of cell shape
E4664_00760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4664_00765	COG0424	maF-like protein
E4664_00770	COG1530	ribonuclease E activity
E4664_00780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4664_00800	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4664_00825	COG2207	Transcriptional regulator
E4664_00885	COG1113	amino acid transport
E4664_00890	COG2828	Protein conserved in bacteria
E4664_00895	COG0142	geranyltranstransferase activity
E4664_00900	COG2315	Protein conserved in bacteria
E4664_00915	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4664_00940	COG2194	sulfuric ester hydrolase activity
E4664_00945	COG0745	RESPONSE REGULATOR receiver
E4664_00950	COG0642	Histidine kinase
E4664_00960	COG0004	ammonium transporteR
E4664_00970	COG0583	DNA-binding transcription factor activity
E4664_00985	COG2226	methyltransferase
E4664_00990	COG0525	valine-tRNA ligase activity
E4664_01000	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_01010	COG0393	Putative heavy-metal-binding
E4664_01015	COG0393	Putative heavy-metal-binding
E4664_01020	COG1538	Outer membrane efflux protein
E4664_01030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4664_01035	COG0671	phosphoesterase, PA-phosphatase related
E4664_01065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4664_01080	COG1648	precorrin-2 dehydrogenase activity
E4664_01080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4664_01085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4664_01100	COG0531	amino acid
E4664_01115	COG0321	lipoyl(octanoyl) transferase activity
E4664_01120	COG2921	Belongs to the UPF0250 family
E4664_01155	COG2009	succinate dehydrogenase
E4664_01160	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4664_01165	COG1053	succinate dehydrogenase
E4664_01170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4664_01195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4664_01215	COG2354	Protein conserved in bacteria
E4664_01220	COG2321	neutral zinc metallopeptidase
E4664_01240	COG2843	Capsule synthesis protein
E4664_01255	COG0589	response to stress
E4664_01265	COG0251	oxidation-reduction process
E4664_01270	COG1309	transcriptional regulator
E4664_01285	COG0505	Belongs to the CarA family
E4664_01310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4664_01315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4664_01365	COG0477	Major facilitator Superfamily
E4664_01370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4664_01390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4664_01415	COG0584	glycerophosphoryl diester phosphodiesterase
E4664_01435	COG0741	lytic transglycosylase activity
E4664_01460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4664_01470	COG0582	viral genome integration into host DNA
E4664_01495	COG2217	Heavy metal translocating P-type atpase
E4664_01500	COG2205	protein histidine kinase activity
E4664_01515	COG2132	Multicopper oxidase
E4664_01545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4664_01565	COG0778	Nitroreductase
E4664_01580	COG1929	Belongs to the glycerate kinase type-1 family
E4664_01585	COG0243	molybdopterin cofactor binding
E4664_01590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4664_01595	COG3339	Conserved Protein
E4664_01605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4664_01620	COG1115	amino acid carrier protein
E4664_01625	COG1113	amino acid transport
E4664_01635	COG0019	diaminopimelate decarboxylase activity
E4664_01645	COG2267	carboxylic ester hydrolase activity
E4664_01650	COG1280	lysine exporter protein (LysE YggA)
E4664_01655	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4664_01685	COG0463	Glycosyl transferase, family 2
E4664_01705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4664_01735	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4664_01740	COG1136	(ABC) transporter
E4664_01745	COG0658	competence protein
E4664_01745	COG2333	competence protein COMEC
E4664_01755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4664_01755	COG0616	signal peptide processing
E4664_01760	COG0596	Alpha beta hydrolase
E4664_01765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4664_01775	COG0628	permease
E4664_01810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4664_01830	COG0823	Involved in the tonB-independent uptake of proteins
E4664_01850	COG0824	Thioesterase
E4664_01855	COG1473	amidohydrolase
E4664_01875	COG0047	phosphoribosylformylglycinamidine synthase activity
E4664_01875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4664_01880	COG2814	Major facilitator Superfamily
E4664_01885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4664_01890	COG1024	Enoyl-CoA hydratase
E4664_01895	COG1056	cytidyltransferase-related domain
E4664_01895	COG1051	belongs to the nudix hydrolase family
E4664_01905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4664_01920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4664_01935	COG4625	pathogenesis
E4664_01940	COG0583	DNA-binding transcription factor activity
E4664_01945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4664_01950	COG4208	sulfate ABC transporter
E4664_01955	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4664_01970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4664_01975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4664_01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4664_02010	COG0681	Belongs to the peptidase S26 family
E4664_02025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4664_02035	COG1381	Involved in DNA repair and RecF pathway recombination
E4664_02040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4664_02050	COG4221	oxidoreductase activity
E4664_02080	COG0443	Heat shock 70 kDa protein
E4664_02110	COG0556	nucleotide-excision repair
E4664_02165	COG2070	2-Nitropropane dioxygenase
E4664_02195	COG1215	transferase activity, transferring glycosyl groups
E4664_02210	COG0415	Belongs to the DNA photolyase family
E4664_02220	COG1252	NADH dehydrogenase
E4664_02225	COG1686	Belongs to the peptidase S11 family
E4664_02240	COG1187	pseudouridine synthase activity
E4664_02265	COG0477	Major facilitator Superfamily
E4664_02270	COG0583	DNA-binding transcription factor activity
E4664_02310	COG0352	thiamine-phosphate diphosphorylase activity
E4664_02345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4664_02360	COG1309	transcriptional regulator
E4664_02370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4664_02375	COG0076	glutamate decarboxylase activity
E4664_02385	COG1522	sequence-specific DNA binding
E4664_02390	COG3961	Belongs to the TPP enzyme family
E4664_02395	COG1113	amino acid transport
E4664_02400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4664_02405	COG0573	inorganic phosphate transmembrane transporter activity
E4664_02415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4664_02420	COG0616	signal peptide processing
E4664_02455	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4664_02460	COG1686	Belongs to the peptidase S11 family
E4664_02485	COG0583	DNA-binding transcription factor activity
E4664_02490	COG1067	ATP-dependent peptidase activity
E4664_02515	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4664_02535	COG1966	Carbon starvation protein
E4664_02540	COG2879	small protein
E4664_02580	COG1741	Belongs to the pirin family
E4664_02590	COG2964	Protein conserved in bacteria
E4664_02605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4664_02610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4664_02615	COG4605	iron ion homeostasis
E4664_02620	COG4604	ABC transporter, ATP-binding protein
E4664_02625	COG4607	ABC-type enterochelin transport system periplasmic component
E4664_02630	COG4774	siderophore transport
E4664_02640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4664_02645	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4664_02650	COG3433	isochorismatase activity
E4664_02650	COG1535	isochorismatase
E4664_02665	COG1132	(ABC) transporter
E4664_02670	COG5265	(ABC) transporter
E4664_02675	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E4664_02685	COG1169	isochorismate synthase
E4664_02700	COG3739	integral membrane protein
E4664_02730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4664_02765	COG0512	Glutamine amidotransferase of anthranilate synthase
E4664_02775	COG3104	oligopeptide transport
E4664_02790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4664_02825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4664_02830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4664_02835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4664_02855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4664_02860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4664_02865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4664_02880	COG1960	acyl-CoA dehydrogenase activity
E4664_02885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4664_02890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4664_02900	COG2223	nitrite transmembrane transporter activity
E4664_02910	COG0024	Methionine aminopeptidase
E4664_02915	COG0052	Belongs to the universal ribosomal protein uS2 family
E4664_02930	COG2207	Transcriptional regulator
E4664_02955	COG2951	lytic endotransglycosylase activity
E4664_02975	COG0842	Transport permease protein
E4664_02980	COG1131	(ABC) transporter
E4664_02985	COG0582	viral genome integration into host DNA
E4664_03030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4664_03555	COG1538	Outer membrane efflux protein
E4664_03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4664_03580	COG4215	(ABC) transporter
E4664_03585	COG4160	amino acid transport
E4664_03590	COG4598	ABC transporter
E4664_03600	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4664_03610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4664_03615	COG0384	phenazine biosynthesis protein PhzF
E4664_03625	COG1720	tRNA m6t6A37 methyltransferase activity
E4664_03645	COG0745	RESPONSE REGULATOR receiver
E4664_03650	COG0642	Histidine kinase
E4664_03660	COG0494	nUDIX hydrolase
E4664_03670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4664_03675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4664_03680	COG3139	Protein of unknown function (DUF1315)
E4664_03695	COG1301	dicarboxylic acid transport
E4664_03700	COG1960	acyl-CoA dehydrogenase activity
E4664_03715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4664_03725	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4664_03745	COG1690	Belongs to the RtcB family
E4664_03750	COG1234	tRNA 3'-trailer cleavage
E4664_03755	COG4650	regulator
E4664_03785	COG2363	Small membrane protein
E4664_03805	COG0513	Belongs to the DEAD box helicase family
E4664_03815	COG0778	Nitroreductase
E4664_03965	COG1286	toxin biosynthetic process
E4664_03990	COG4783	chaperone-mediated protein folding
E4664_03995	COG1610	YqeY-like protein
E4664_04000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4664_04095	COG3111	PFAM Bacterial OB fold (BOF) protein
E4664_04120	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4664_04125	COG0786	glutamate:sodium symporter activity
E4664_04135	COG2186	Transcriptional regulator
E4664_04140	COG1051	belongs to the nudix hydrolase family
E4664_04175	COG2995	paraquat-inducible protein a
E4664_04180	COG3008	intermembrane lipid transfer
E4664_04180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4664_04190	COG2351	hydroxyisourate hydrolase activity
E4664_04230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4664_04240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4664_04245	COG0642	Histidine kinase
E4664_04250	COG0745	RESPONSE REGULATOR receiver
E4664_04270	COG1794	racemase activity, acting on amino acids and derivatives
E4664_04300	COG1301	dicarboxylic acid transport
E4664_04310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4664_04315	COG2011	ABC-type metal ion transport system permease component
E4664_04320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4664_04325	COG1464	Belongs to the NlpA lipoprotein family
E4664_04330	COG0151	Belongs to the GarS family
E4664_04335	COG0138	bifunctional purine biosynthesis protein purh
E4664_04340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4664_04370	COG2308	Evidence 4 Homologs of previously reported genes of
E4664_04380	COG1305	Transglutaminase-like
E4664_04390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4664_04395	COG0305	Participates in initiation and elongation during chromosome replication
E4664_04420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4664_04430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4664_04435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4664_04460	COG0726	polysaccharide deacetylase
E4664_04460	COG1649	PFAM Uncharacterised BCR, COG1649
E4664_04465	COG1215	transferase activity, transferring glycosyl groups
E4664_04470	COG3658	cytochrome
E4664_04480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4664_04500	COG0583	DNA-binding transcription factor activity
E4664_04530	COG1960	acyl-CoA dehydrogenase activity
E4664_04535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4664_04540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4664_04565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4664_04570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4664_04575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E4664_04580	COG2205	protein histidine kinase activity
E4664_04585	COG0745	RESPONSE REGULATOR receiver
E4664_04590	COG0174	glutamine synthetase
E4664_04610	COG0729	surface antigen
E4664_04650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4664_04745	COG1484	DNA-dependent DNA replication
E4664_04940	COG2026	Addiction module toxin, RelE StbE family
E4664_04980	COG0592	DNA-directed DNA polymerase activity
E4664_05065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4664_05095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4664_05100	COG2814	Major facilitator Superfamily
E4664_05115	COG0583	DNA-binding transcription factor activity
E4664_05130	COG1187	pseudouridine synthase activity
E4664_05150	COG0802	atpase or kinase
E4664_05155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4664_05165	COG1923	regulation of RNA biosynthetic process
E4664_05170	COG0697	spore germination
E4664_05185	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4664_05200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4664_05200	COG0519	Catalyzes the synthesis of GMP from XMP
E4664_05205	COG4302	ethanolamine ammonia-lyase activity
E4664_05210	COG4303	Ethanolamine ammonia lyase large subunit
E4664_05215	COG0531	amino acid
E4664_05235	COG1454	alcohol dehydrogenase
E4664_05240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4664_05265	COG0308	aminopeptidase N
E4664_05305	COG1605	Chorismate mutase
E4664_05325	COG1309	transcriptional regulator
E4664_05335	COG0668	transmembrane transport
E4664_05365	COG3328	transposase activity
E4664_05375	COG4773	Receptor
E4664_05395	COG0488	(ABC) transporter
E4664_05400	COG0589	response to stress
E4664_05415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4664_05425	COG3135	benzoate transporter
E4664_05430	COG1522	sequence-specific DNA binding
E4664_05445	COG0583	DNA-binding transcription factor activity
E4664_05455	COG0183	Belongs to the thiolase family
E4664_05495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4664_05505	COG0824	Thioesterase
E4664_05510	COG1454	alcohol dehydrogenase
E4664_05520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4664_05550	COG0069	glutamate synthase activity
E4664_05695	COG2814	Major facilitator Superfamily
E4664_05710	COG0511	ligase activity, forming carbon-carbon bonds
E4664_05730	COG1116	anion transmembrane transporter activity
E4664_05730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4664_05735	COG0745	RESPONSE REGULATOR receiver
E4664_05745	COG2146	nitrite reductase [NAD(P)H] activity
E4664_05745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4664_05750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4664_05755	COG0243	molybdopterin cofactor binding
E4664_05770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4664_05785	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4664_05785	COG0315	cyclic pyranopterin monophosphate synthase activity
E4664_05790	COG0303	'Molybdopterin
E4664_05800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4664_05805	COG0697	spore germination
E4664_05825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4664_05830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4664_05890	COG2204	response regulator
E4664_05895	COG3852	Histidine kinase
E4664_05920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4664_05925	COG0575	Belongs to the CDS family
E4664_05940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4664_05960	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4664_05975	COG2137	regulation of response to DNA damage stimulus
E4664_05985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4664_05990	COG1011	Hydrolase
E4664_06015	COG1522	sequence-specific DNA binding
E4664_06025	COG1113	amino acid transport
E4664_06040	COG0659	secondary active sulfate transmembrane transporter activity
E4664_06045	COG2135	peptidase activity
E4664_06060	COG5001	Diguanylate cyclase
E4664_06060	COG3300	MHYT domain
E4664_06075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4664_06075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4664_06075	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4664_06080	COG1105	Belongs to the carbohydrate kinase PfkB family
E4664_06085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4664_06085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4664_06115	COG0024	Methionine aminopeptidase
E4664_06120	COG0583	DNA-binding transcription factor activity
E4664_06130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4664_06135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4664_06140	COG0517	IMP dehydrogenase activity
E4664_06140	COG0516	GMP reductase activity
E4664_06165	COG0552	protein localization to endoplasmic reticulum
E4664_06175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E4664_06190	COG4890	Cyd operon protein YbgT
E4664_06195	COG1294	oxidase, subunit
E4664_06210	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4664_06220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4664_06225	COG4774	siderophore transport
E4664_06240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4664_06245	COG0569	domain protein
E4664_06250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4664_06280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4664_06285	COG0542	response to heat
E4664_06295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4664_06310	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4664_06310	COG1902	pentaerythritol trinitrate reductase activity
E4664_06355	COG2323	membrane
E4664_06365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4664_06375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4664_06380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4664_06385	COG0183	Belongs to the thiolase family
E4664_06390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4664_06395	COG0596	Alpha beta hydrolase
E4664_06400	COG2271	Major facilitator Superfamily
E4664_06405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4664_06410	COG3485	protocatechuate 3,4-dioxygenase
E4664_06415	COG3485	protocatechuate 3,4-dioxygenase
E4664_06420	COG0710	3-dehydroquinate dehydratase activity
E4664_06425	COG3420	alginic acid biosynthetic process
E4664_06430	COG3659	wide pore channel activity
E4664_06435	COG4993	Dehydrogenase
E4664_06445	COG2391	methyltransferase activity
E4664_06460	COG1414	Transcriptional regulator
E4664_06465	COG0583	DNA-binding transcription factor activity
E4664_06470	COG1960	acyl-CoA dehydrogenase activity
E4664_06500	COG2814	Major facilitator Superfamily
E4664_06510	COG0154	amidase activity
E4664_06530	COG4638	Rieske (2fe-2S)
E4664_06540	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_06550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4664_06560	COG3733	amine oxidase
E4664_06570	COG1012	belongs to the aldehyde dehydrogenase family
E4664_06580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4664_06585	COG0183	Belongs to the thiolase family
E4664_06590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4664_06605	COG4829	muconolactone delta-isomerase
E4664_06610	COG4948	Mandelate Racemase Muconate Lactonizing
E4664_06615	COG0583	DNA-binding transcription factor activity
E4664_06625	COG2186	Transcriptional regulator
E4664_06645	COG1012	belongs to the aldehyde dehydrogenase family
E4664_06660	COG1902	pentaerythritol trinitrate reductase activity
E4664_06660	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4664_06700	COG1309	transcriptional regulator
E4664_06705	COG0583	DNA-binding transcription factor activity
E4664_06710	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_06715	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_06720	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_06730	COG1960	acyl-CoA dehydrogenase activity
E4664_06740	COG0318	PFAM AMP-dependent synthetase and ligase
E4664_06805	COG0583	DNA-binding transcription factor activity
E4664_06830	COG1566	PFAM secretion protein HlyD family protein
E4664_06845	COG1012	belongs to the aldehyde dehydrogenase family
E4664_06850	COG0129	dihydroxy-acid dehydratase activity
E4664_06860	COG0583	DNA-binding transcription factor activity
E4664_06865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4664_06875	COG2084	Dehydrogenase
E4664_06895	COG1120	ATPase activity
E4664_06915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4664_06965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E4664_07020	COG2205	protein histidine kinase activity
E4664_07045	COG3539	Fimbrial protein
E4664_07070	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4664_07080	COG0753	catalase activity
E4664_07095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4664_07160	COG3433	isochorismatase activity
E4664_07160	COG1535	isochorismatase
E4664_07165	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_07170	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4664_07175	COG4149	molybdate abc transporter
E4664_07180	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4664_07190	COG4638	Rieske (2fe-2S)
E4664_07195	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4664_07200	COG0543	2 iron, 2 sulfur cluster binding
E4664_07200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4664_07215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4664_07240	COG0412	Dienelactone hydrolase
E4664_07250	COG2207	Transcriptional regulator
E4664_07255	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_07260	COG2610	gluconate transmembrane transporter activity
E4664_07270	COG0583	DNA-binding transcription factor activity
E4664_07285	COG2031	fatty acid transporter
E4664_07290	COG0183	Belongs to the thiolase family
E4664_07295	COG0583	DNA-binding transcription factor activity
E4664_07300	COG0583	DNA-binding transcription factor activity
E4664_07315	COG1027	Aspartate ammonia-lyase
E4664_07325	COG0477	Major facilitator Superfamily
E4664_07345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4664_07350	COG4521	taurine ABC transporter
E4664_07375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4664_07380	COG1733	regulation of RNA biosynthetic process
E4664_07385	COG3708	Transcriptional regulator
E4664_07385	COG2207	Transcriptional regulator
E4664_07400	COG0730	response to heat
E4664_07410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4664_07410	COG3453	Protein conserved in bacteria
E4664_07420	COG3781	membrane
E4664_07425	COG1063	alcohol dehydrogenase
E4664_07435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4664_07440	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4664_07445	COG0022	dehydrogenase e1 component
E4664_07450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4664_07455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4664_07470	COG3706	GGDEF domain
E4664_07485	COG0133	tryptophan synthase activity
E4664_07495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4664_07530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4664_07555	COG2226	methyltransferase
E4664_07585	COG0537	adenosine 5'-monophosphoramidase activity
E4664_07610	COG0842	Transport permease protein
E4664_07615	COG0842	Transport permease protein
E4664_07620	COG1131	(ABC) transporter
E4664_07635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4664_07640	COG4773	Receptor
E4664_07670	COG0730	response to heat
E4664_07675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4664_07690	COG0406	alpha-ribazole phosphatase activity
E4664_07695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4664_07710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4664_07745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4664_07755	COG4264	IucA IucC family
E4664_07760	COG4264	IucA IucC family
E4664_07765	COG2814	Major facilitator Superfamily
E4664_07780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4664_07795	COG1960	acyl-CoA dehydrogenase activity
E4664_07800	COG1960	acyl-CoA dehydrogenase activity
E4664_07805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4664_07810	COG2207	Transcriptional regulator
E4664_07815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4664_07820	COG0776	regulation of translation
E4664_07845	COG0822	iron-sulfur transferase activity
E4664_07850	COG0316	Belongs to the HesB IscA family
E4664_07880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4664_07900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4664_07905	COG0702	epimerase
E4664_07945	COG0601	transmembrane transport
E4664_07950	COG0339	signal peptide processing
E4664_07955	COG4166	transmembrane transport
E4664_08000	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4664_08055	COG0739	heme binding
E4664_08055	COG0741	lytic transglycosylase activity
E4664_08055	COG1196	nuclear chromosome segregation
E4664_08195	COG0305	Participates in initiation and elongation during chromosome replication
E4664_08265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4664_08295	COG0776	regulation of translation
E4664_08315	COG0590	tRNA wobble adenosine to inosine editing
E4664_08345	COG2165	general secretion pathway protein
E4664_08360	COG0084	hydrolase, TatD family'
E4664_08380	COG1663	tetraacyldisaccharide 4'-kinase activity
E4664_08385	COG1132	(ABC) transporter
E4664_08395	COG0811	peptide transport
E4664_08400	COG1475	DNA binding
E4664_08405	COG1192	Involved in chromosome partitioning
E4664_08415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4664_08430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4664_08435	COG0191	fructose-bisphosphate aldolase activity
E4664_08455	COG0424	maF-like protein
E4664_08460	COG2850	peptidyl-arginine hydroxylation
E4664_08470	COG0640	Transcriptional regulator
E4664_08480	COG3619	membrane
E4664_08485	COG3122	Protein conserved in bacteria
E4664_08495	COG1132	(ABC) transporter
E4664_08515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4664_08520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4664_08530	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4664_08530	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4664_08530	COG0506	proline dehydrogenase activity
E4664_08535	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4664_08550	COG3698	Phosphodiester glycosidase
E4664_08560	COG2353	YceI-like domain
E4664_08570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4664_08615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4664_08615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4664_08640	COG3539	Fimbrial protein
E4664_08645	COG3121	Chaperone
E4664_08675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4664_08685	COG0583	DNA-binding transcription factor activity
E4664_08705	COG1309	transcriptional regulator
E4664_08720	COG1522	sequence-specific DNA binding
E4664_08730	COG1126	abc transporter atp-binding protein
E4664_08735	COG0765	amino acid transport
E4664_08740	COG0765	amino acid transport
E4664_08770	COG1464	Belongs to the NlpA lipoprotein family
E4664_08780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4664_08785	COG2011	ABC-type metal ion transport system permease component
E4664_08790	COG0012	GTP binding
E4664_08815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4664_08860	COG4372	Transposase
E4664_08875	COG0386	Belongs to the glutathione peroxidase family
E4664_08885	COG0436	Aminotransferase
E4664_08890	COG1301	dicarboxylic acid transport
E4664_08940	COG0583	DNA-binding transcription factor activity
E4664_08945	COG0798	PFAM Bile acid sodium symporter
E4664_08950	COG0640	Transcriptional regulator
E4664_08965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4664_08975	COG0583	DNA-binding transcription factor activity
E4664_08985	COG1953	Uracil, thiamine, allantoin
E4664_08995	COG2175	clavaminate synthase activity
E4664_09000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4664_09005	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4664_09010	COG4521	taurine ABC transporter
E4664_09020	COG0477	Major facilitator Superfamily
E4664_09045	COG1271	oxidase subunit
E4664_09050	COG1294	oxidase, subunit
E4664_09060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4664_09080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4664_09105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4664_09115	COG2814	Major facilitator Superfamily
E4664_09130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4664_09135	COG1346	cytolysis
E4664_09145	COG0583	DNA-binding transcription factor activity
E4664_09150	COG0625	glutathione transferase activity
E4664_09155	COG0625	glutathione transferase activity
E4664_09160	COG0583	DNA-binding transcription factor activity
E4664_09165	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_09175	COG1045	serine acetyltransferase
E4664_09180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4664_09185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4664_09195	COG1280	lysine exporter protein (LysE YggA)
E4664_09205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4664_09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4664_09215	COG1126	abc transporter atp-binding protein
E4664_09220	COG0765	amino acid transport
E4664_09225	COG0765	amino acid transport
E4664_09245	COG0784	Response regulator, receiver
E4664_09245	COG2205	protein histidine kinase activity
E4664_09265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4664_09285	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_09330	COG0583	DNA-binding transcription factor activity
E4664_09355	COG0318	PFAM AMP-dependent synthetase and ligase
E4664_09360	COG1309	transcriptional regulator
E4664_09365	COG1960	acyl-CoA dehydrogenase activity
E4664_09370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4664_09375	COG1024	Enoyl-CoA hydratase
E4664_09390	COG0583	DNA-binding transcription factor activity
E4664_09405	COG1960	acyl-CoA dehydrogenase activity
E4664_09415	COG2814	Major facilitator Superfamily
E4664_09425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4664_09430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4664_09435	COG2814	Major facilitator Superfamily
E4664_09440	COG1960	acyl-CoA dehydrogenase activity
E4664_09445	COG1024	Enoyl-CoA hydratase
E4664_09450	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_09455	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4664_09460	COG0183	Belongs to the thiolase family
E4664_09470	COG2814	Major facilitator Superfamily
E4664_09480	COG1024	Enoyl-CoA hydratase
E4664_09495	COG1960	acyl-CoA dehydrogenase activity
E4664_09500	COG2814	Major facilitator Superfamily
E4664_09505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4664_09510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4664_09525	COG3842	ATPase activity
E4664_09530	COG1840	ABC-type Fe3 transport system, periplasmic component
E4664_09545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4664_09550	COG1414	Transcriptional regulator
E4664_09560	COG0583	DNA-binding transcription factor activity
E4664_09565	COG3038	cytochrome b561
E4664_09570	COG0753	catalase activity
E4664_09605	COG0406	alpha-ribazole phosphatase activity
E4664_09625	COG2050	protein possibly involved in aromatic compounds catabolism
E4664_09635	COG3327	negative regulation of DNA-templated transcription, initiation
E4664_09640	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E4664_09645	COG0183	Belongs to the thiolase family
E4664_09650	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4664_09655	COG1024	Enoyl-CoA hydratase
E4664_09660	COG1024	Enoyl-CoA hydratase
E4664_09665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4664_09670	COG2151	metal-sulfur cluster biosynthetic enzyme
E4664_09675	COG3396	Phenylacetate-CoA oxygenase
E4664_09680	COG3460	Phenylacetate-CoA oxygenase
E4664_09685	COG3396	Phenylacetate-CoA oxygenase
E4664_09690	COG2030	dehydratase
E4664_09690	COG1012	belongs to the aldehyde dehydrogenase family
E4664_09695	COG1760	l-serine dehydratase
E4664_09700	COG0531	amino acid
E4664_09705	COG1012	belongs to the aldehyde dehydrogenase family
E4664_09750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4664_09765	COG0789	Transcriptional regulator
E4664_09775	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4664_09790	COG2807	transmembrane transport
E4664_09795	COG0590	tRNA wobble adenosine to inosine editing
E4664_09805	COG0583	DNA-binding transcription factor activity
E4664_09845	COG2885	chlorophyll binding
E4664_09845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4664_09960	COG1116	anion transmembrane transporter activity
E4664_09965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4664_09975	COG0864	Transcriptional regulator
E4664_09990	COG1733	regulation of RNA biosynthetic process
E4664_09995	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4664_10025	COG1309	transcriptional regulator
E4664_10040	COG0038	chloride channel
E4664_10045	COG4770	biotin carboxylase activity
E4664_10065	COG1914	H( )-stimulated, divalent metal cation uptake system
E4664_10070	COG0583	DNA-binding transcription factor activity
E4664_10100	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4664_10120	COG2814	Major facilitator Superfamily
E4664_10135	COG1560	Kdo2-lipid A biosynthetic process
E4664_10145	COG5006	permease, DMT superfamily
E4664_10150	COG1522	sequence-specific DNA binding
E4664_10165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4664_10210	COG1137	ATPase activity
E4664_10215	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4664_10225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4664_10270	COG1733	regulation of RNA biosynthetic process
E4664_10275	COG2814	Major facilitator Superfamily
E4664_10315	COG1278	Cold shock
E4664_10320	COG1280	lysine exporter protein (LysE YggA)
E4664_10350	COG1570	exodeoxyribonuclease VII activity
E4664_10405	COG0583	DNA-binding transcription factor activity
E4664_10410	COG4638	Rieske (2fe-2S)
E4664_10415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4664_10420	COG0633	Ferredoxin
E4664_10420	COG0543	2 iron, 2 sulfur cluster binding
E4664_10425	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_10430	COG3135	benzoate transporter
E4664_10435	COG2814	Major facilitator Superfamily
E4664_10450	COG1643	Atp-dependent helicase
E4664_10455	COG0450	alkyl hydroperoxide reductase
E4664_10465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4664_10475	COG3634	alkyl hydroperoxide reductase activity
E4664_10495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4664_10515	COG0625	glutathione transferase activity
E4664_10525	COG2885	chlorophyll binding
E4664_10580	COG1765	OsmC-like protein
E4664_10590	COG0667	Aldo Keto reductase
E4664_10605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4664_10615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4664_10625	COG0582	viral genome integration into host DNA
E4664_10670	COG3179	chitinase
E4664_10815	COG5410	chromosome segregation
E4664_10955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4664_10965	COG3038	cytochrome b561
E4664_10970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4664_10975	COG2252	PERMEase
E4664_10985	COG2072	flavoprotein involved in K transport
E4664_11000	COG1741	Belongs to the pirin family
E4664_11005	COG1309	transcriptional regulator
E4664_11015	COG0300	oxidoreductase activity
E4664_11020	COG2072	flavoprotein involved in K transport
E4664_11025	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4664_11085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4664_11100	COG2814	Major facilitator Superfamily
E4664_11105	COG1024	Enoyl-CoA hydratase
E4664_11110	COG1012	belongs to the aldehyde dehydrogenase family
E4664_11120	COG1960	acyl-CoA dehydrogenase activity
E4664_11145	COG2186	Transcriptional regulator
E4664_11150	COG1012	belongs to the aldehyde dehydrogenase family
E4664_11160	COG4948	Mandelate Racemase Muconate Lactonizing
E4664_11165	COG2271	Major facilitator Superfamily
E4664_11170	COG2721	sulfolactate sulfo-lyase activity
E4664_11175	COG0697	spore germination
E4664_11200	COG1113	amino acid transport
E4664_11220	COG1012	belongs to the aldehyde dehydrogenase family
E4664_11240	COG0531	amino acid
E4664_11250	COG1113	amino acid transport
E4664_11290	COG4269	membrane
E4664_11310	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E4664_11310	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E4664_11335	COG0514	ATP-dependent DNA helicase (RecQ)
E4664_11440	COG2161	toxin-antitoxin pair type II binding
E4664_11460	COG0582	viral genome integration into host DNA
E4664_11470	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4664_11470	COG1902	pentaerythritol trinitrate reductase activity
E4664_11480	COG4251	negative regulation of phosphorylation
E4664_11480	COG3706	GGDEF domain
E4664_11480	COG2203	Gaf domain
E4664_11480	COG5001	Diguanylate cyclase
E4664_11490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4664_11510	COG4172	Belongs to the ABC transporter superfamily
E4664_11515	COG4239	(ABC) transporter, permease
E4664_11520	COG4174	ABC transporter (Permease)
E4664_11530	COG1388	LysM domain
E4664_11530	COG0741	lytic transglycosylase activity
E4664_11535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4664_11575	COG0583	DNA-binding transcription factor activity
E4664_11580	COG1279	arginine transmembrane transporter activity
E4664_11600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4664_11605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4664_11760	COG3620	sequence-specific DNA binding
E4664_11815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4664_11835	COG3384	dioxygenase
E4664_11845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4664_11850	COG2878	Part of a membrane complex involved in electron transport
E4664_11855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4664_11880	COG0768	penicillin binding
E4664_11885	COG0742	ribosomal rna small subunit methyltransferase
E4664_11900	COG0830	nickel cation binding
E4664_11910	COG0804	urea catabolic process
E4664_11950	COG1253	flavin adenine dinucleotide binding
E4664_11960	COG2851	Citrate transporter
E4664_12010	COG1773	rubredoxin
E4664_12015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4664_12025	COG0583	DNA-binding transcription factor activity
E4664_12065	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4664_12070	COG4181	ATPase activity
E4664_12115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4664_12135	COG0306	phosphate transporter
E4664_12180	COG2223	nitrite transmembrane transporter activity
E4664_12185	COG2207	Transcriptional regulator
E4664_12190	COG2066	Belongs to the glutaminase family
E4664_12195	COG0242	peptide deformylase activity
E4664_12200	COG0477	Major facilitator Superfamily
E4664_12210	COG0028	Belongs to the TPP enzyme family
E4664_12225	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_12230	COG2267	carboxylic ester hydrolase activity
E4664_12240	COG2271	Major facilitator Superfamily
E4664_12255	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_12275	COG1414	Transcriptional regulator
E4664_12290	COG1024	Enoyl-CoA hydratase
E4664_12300	COG1215	transferase activity, transferring glycosyl groups
E4664_12305	COG0726	polysaccharide deacetylase
E4664_12305	COG1649	PFAM Uncharacterised BCR, COG1649
E4664_12315	COG4681	YaeQ
E4664_12325	COG0523	cobalamin synthesis protein
E4664_12335	COG1607	acyl-coa hydrolase
E4664_12345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4664_12350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4664_12355	COG1309	transcriptional regulator
E4664_12380	COG2040	homocysteine
E4664_12385	COG0531	amino acid
E4664_12440	COG1595	DNA-templated transcription, initiation
E4664_12450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4664_12455	COG0477	Major facilitator Superfamily
E4664_12485	COG0405	Gamma-glutamyltransferase
E4664_12490	COG2814	Major facilitator Superfamily
E4664_12500	COG2050	protein possibly involved in aromatic compounds catabolism
E4664_12515	COG1090	epimerase
E4664_12535	COG0420	3'-5' exonuclease activity
E4664_12560	COG0735	belongs to the Fur family
E4664_12565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4664_12590	COG0121	glutamine amidotransferase
E4664_12605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4664_12615	COG0210	DNA helicase
E4664_12620	COG2885	chlorophyll binding
E4664_12625	COG0204	Acyl-transferase
E4664_12640	COG2894	cell division
E4664_12655	COG1280	lysine exporter protein (LysE YggA)
E4664_12660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4664_12660	COG1674	ftsk spoiiie
E4664_12665	COG0492	ferredoxin-NADP+ reductase activity
E4664_12670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4664_12680	COG0456	acetyltransferase
E4664_12740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4664_12740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4664_12760	COG1012	belongs to the aldehyde dehydrogenase family
E4664_12785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4664_12810	COG0564	pseudouridine synthase activity
E4664_12820	COG0358	DNA primase activity
E4664_12835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4664_12865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4664_12895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4664_12905	COG0351	phosphomethylpyrimidine kinase
E4664_12905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4664_12905	COG0352	thiamine-phosphate diphosphorylase activity
E4664_12910	COG1652	LysM domain
E4664_12935	COG1399	metal-binding, possibly nucleic acid-binding protein
E4664_12940	COG3101	peptidyl-lysine hydroxylation
E4664_12945	COG0009	L-threonylcarbamoyladenylate synthase
E4664_12950	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4664_12955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4664_12970	COG4106	trans-aconitate 2-methyltransferase activity
E4664_12985	COG0596	Alpha beta hydrolase
E4664_12985	COG2226	methyltransferase
E4664_12985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4664_12990	COG1877	trehalose-phosphatase activity
E4664_12995	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4664_13000	COG2223	nitrite transmembrane transporter activity
E4664_13020	COG1196	nuclear chromosome segregation
E4664_13030	COG0730	response to heat
E4664_13045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4664_13055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4664_13115	COG0489	protein tyrosine kinase activity
E4664_13125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4664_13125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4664_13155	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E4664_13160	COG2081	HI0933 family
E4664_13170	COG0668	transmembrane transport
E4664_13190	COG0583	DNA-binding transcription factor activity
E4664_13210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4664_13215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4664_13245	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4664_13280	COG2205	protein histidine kinase activity
E4664_13285	COG0745	RESPONSE REGULATOR receiver
E4664_13305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4664_13325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4664_13330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4664_13340	COG0583	DNA-binding transcription factor activity
E4664_13370	COG0583	DNA-binding transcription factor activity
E4664_13390	COG0583	DNA-binding transcription factor activity
E4664_13395	COG1053	succinate dehydrogenase
E4664_13405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4664_13410	COG2814	Major facilitator Superfamily
E4664_13415	COG1960	acyl-CoA dehydrogenase activity
E4664_13420	COG0583	DNA-binding transcription factor activity
E4664_13425	COG1063	alcohol dehydrogenase
E4664_13455	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4664_13460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4664_13465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4664_13485	COG2132	Multicopper oxidase
E4664_13495	COG0561	phosphatase activity
E4664_13500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4664_13510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4664_13525	COG1214	PFAM Peptidase M22, glycoprotease
E4664_13560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4664_13570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4664_13575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4664_13580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4664_13640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4664_13650	COG1846	Transcriptional regulator
E4664_13655	COG1764	response to oxidative stress
E4664_13695	COG0037	tRNA processing
E4664_13705	COG0248	Ppx GppA phosphatase
E4664_13735	COG0072	phenylalanine-tRNA ligase activity
E4664_13760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4664_13775	COG1238	metal cluster binding
E4664_13780	COG0625	glutathione transferase activity
E4664_13800	COG0318	PFAM AMP-dependent synthetase and ligase
E4664_13805	COG3028	Belongs to the UPF0307 family
E4664_13810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4664_13830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4664_13835	COG0617	tRNA 3'-terminal CCA addition
E4664_13840	COG1555	photosystem II stabilization
E4664_13845	COG3956	TIGRFAM MazG family protein
E4664_13855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4664_13875	COG0784	Response regulator, receiver
E4664_13875	COG5002	protein histidine kinase activity
E4664_13875	COG2205	protein histidine kinase activity
E4664_13880	COG1024	Enoyl-CoA hydratase
E4664_13885	COG2084	Dehydrogenase
E4664_13890	COG3622	Belongs to the hyi family
E4664_13905	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4664_13910	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4664_13915	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4664_13920	COG0697	spore germination
E4664_13930	COG2814	Major facilitator Superfamily
E4664_13935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4664_13945	COG0583	DNA-binding transcription factor activity
E4664_13955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4664_13965	COG0084	hydrolase, TatD family'
E4664_13980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4664_14005	COG2130	NADP-dependent
E4664_14010	COG1309	transcriptional regulator
E4664_14020	COG1902	pentaerythritol trinitrate reductase activity
E4664_14030	COG1979	alcohol dehydrogenase
E4664_14045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4664_14060	COG0604	alcohol dehydrogenase
E4664_14060	COG3321	synthase
E4664_14065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4664_14070	COG0583	DNA-binding transcription factor activity
E4664_14075	COG4221	oxidoreductase activity
E4664_14135	COG0440	acetolactate synthase activity
E4664_14140	COG0028	Belongs to the TPP enzyme family
E4664_14165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4664_14170	COG0577	efflux transmembrane transporter activity
E4664_14170	COG1136	(ABC) transporter
E4664_14175	COG1538	Outer membrane efflux protein
E4664_14190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4664_14195	COG1162	GTPase activity
E4664_14205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4664_14245	COG1426	Protein conserved in bacteria
E4664_14280	COG0793	Belongs to the peptidase S41A family
E4664_14295	COG2267	carboxylic ester hydrolase activity
E4664_14305	COG1012	belongs to the aldehyde dehydrogenase family
E4664_14310	COG3265	gluconokinase activity
E4664_14320	COG0800	Aldolase
E4664_14330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4664_14335	COG0857	belongs to the CobB CobQ family
E4664_14335	COG0280	phosphate acetyltransferase
E4664_14340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4664_14340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4664_14360	COG0740	serine-type endopeptidase activity
E4664_14370	COG4774	siderophore transport
E4664_14380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4664_14390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4664_14390	COG2813	Specifically methylates the guanine in position
E4664_14495	COG0788	formyltetrahydrofolate deformylase activity
E4664_14510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4664_14515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4664_14520	COG4651	solute:proton antiporter activity
E4664_14520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4664_14540	COG0724	RNA recognition motif
E4664_14545	COG0210	DNA helicase
E4664_14570	COG1733	regulation of RNA biosynthetic process
E4664_14590	COG1280	lysine exporter protein (LysE YggA)
E4664_14595	COG1560	Kdo2-lipid A biosynthetic process
E4664_14605	COG1301	dicarboxylic acid transport
E4664_14660	COG0473	3-isopropylmalate dehydrogenase activity
E4664_14725	COG0583	DNA-binding transcription factor activity
E4664_14735	COG0625	glutathione transferase activity
E4664_14740	COG2378	regulation of single-species biofilm formation
E4664_14745	COG0546	phosphoglycolate phosphatase activity
E4664_14760	COG1530	ribonuclease E activity
E4664_14780	COG0583	DNA-binding transcription factor activity
E4664_14785	COG4221	oxidoreductase activity
E4664_14790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4664_14800	COG0534	Mate efflux family protein
E4664_14815	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4664_14855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4664_14860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4664_14875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4664_14885	COG0644	oxidoreductase
E4664_14885	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4664_14895	COG0425	Belongs to the sulfur carrier protein TusA family
E4664_14900	COG4535	Mg2 and Co2 transporter CorC
E4664_14910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4664_14930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4664_14935	COG0475	glutathione-regulated potassium exporter activity
E4664_14935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4664_14950	COG0484	heat shock protein binding
E4664_14955	COG0789	Transcriptional regulator
E4664_14960	COG0598	Magnesium transport protein CorA
E4664_14980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4664_14985	COG1074	ATP-dependent DNA helicase activity
E4664_15010	COG2226	methyltransferase
E4664_15025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4664_15045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4664_15045	COG2111	Na H antiporter
E4664_15050	COG1006	Multisubunit Na H antiporter MnhC subunit
E4664_15055	COG0651	ATP synthesis coupled electron transport
E4664_15065	COG2212	antiporter activity
E4664_15085	COG0195	Participates in both transcription termination and antitermination
E4664_15135	COG0237	dephospho-CoA kinase activity
E4664_15145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4664_15160	COG0497	DNA recombination
E4664_15170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4664_15200	COG2169	Transcriptional regulator
E4664_15200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4664_15205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4664_15270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4664_15285	COG0326	Molecular chaperone. Has ATPase activity
E4664_15300	COG2056	Na+-H+ antiporter family
E4664_15305	COG0596	Alpha beta hydrolase
E4664_15405	COG0546	phosphoglycolate phosphatase activity
E4664_15410	COG1716	ATPase activity
E4664_15455	COG0181	hydroxymethylbilane synthase activity
E4664_15465	COG3275	phosphorelay sensor kinase activity
E4664_15485	COG1538	Outer membrane efflux protein
E4664_15490	COG0697	spore germination
E4664_15515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4664_15520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4664_15525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4664_15530	COG0772	Belongs to the SEDS family
E4664_15555	COG4974	Belongs to the 'phage' integrase family
E4664_15560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4664_15570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4664_15580	COG2197	response regulator
E4664_15595	COG0793	Belongs to the peptidase S41A family
E4664_15600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4664_15605	COG0795	lipopolysaccharide-transporting ATPase activity
E4664_15645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4664_15645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4664_15655	COG0004	ammonium transporteR
E4664_15660	COG0347	Belongs to the P(II) protein family
E4664_15670	COG0606	chelatase, subunit chli
E4664_15695	COG1061	Type III restriction enzyme res subunit
E4664_15710	COG0659	secondary active sulfate transmembrane transporter activity
E4664_15715	COG0589	response to stress
E4664_15755	COG0606	chelatase, subunit chli
E4664_15760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4664_15765	COG0235	Class ii aldolase
E4664_15770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4664_15785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4664_15800	COG0318	PFAM AMP-dependent synthetase and ligase
E4664_15810	COG0477	Major facilitator Superfamily
E4664_15815	COG2860	membrane
E4664_15820	COG3012	SEC-C Motif Domain Protein
E4664_15825	COG1253	flavin adenine dinucleotide binding
E4664_15835	COG2814	Major facilitator Superfamily
E4664_15845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4664_15880	COG0655	NAD(P)H dehydrogenase (quinone) activity
E4664_15890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4664_15925	COG1309	transcriptional regulator
E4664_15960	COG0758	DNA mediated transformation
E4664_15970	COG0697	spore germination
E4664_15975	COG1309	transcriptional regulator
E4664_15990	COG0386	Belongs to the glutathione peroxidase family
E4664_16060	COG1121	(ABC) transporter
E4664_16065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4664_16070	COG1280	lysine exporter protein (LysE YggA)
E4664_16075	COG2837	iron assimilation
E4664_16085	COG0281	malic enzyme
E4664_16130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4664_16130	COG0519	Catalyzes the synthesis of GMP from XMP
E4664_16135	COG4399	Belongs to the UPF0754 family
E4664_16140	COG2259	Doxx family
E4664_16145	COG0586	Pfam SNARE associated Golgi protein
E4664_16160	COG1192	Involved in chromosome partitioning
E4664_16170	COG0271	Belongs to the BolA IbaG family
E4664_16185	COG0477	Major facilitator Superfamily
E4664_16190	COG1024	Enoyl-CoA hydratase
E4664_16195	COG1024	Enoyl-CoA hydratase
E4664_16200	COG1960	acyl-CoA dehydrogenase activity
E4664_16205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4664_16225	COG1113	amino acid transport
E4664_16230	COG1113	amino acid transport
E4664_16235	COG0251	oxidation-reduction process
E4664_16250	COG1522	sequence-specific DNA binding
E4664_16275	COG0564	pseudouridine synthase activity
E4664_16345	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4664_16360	COG1802	Transcriptional regulator
E4664_16370	COG1448	Aminotransferase
E4664_16375	COG0277	FAD linked oxidase domain protein
E4664_16385	COG2186	Transcriptional regulator
E4664_16395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4664_16400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4664_16415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4664_16420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4664_16425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4664_16440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4664_16475	COG1083	cytidylyl-transferase
E4664_16480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4664_16490	COG2089	acid synthase
E4664_16495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4664_16500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4664_16505	COG1086	Polysaccharide biosynthesis protein
E4664_16510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4664_16515	COG1596	polysaccharide export
E4664_16540	COG0728	peptidoglycan biosynthetic process
E4664_16545	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4664_16600	COG0546	phosphoglycolate phosphatase activity
E4664_16605	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_16625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4664_16630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4664_16635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4664_16640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4664_16645	COG1116	anion transmembrane transporter activity
E4664_16650	COG1309	transcriptional regulator
E4664_16655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4664_16665	COG0196	riboflavin kinase activity
E4664_16670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4664_16680	COG1047	Peptidyl-prolyl cis-trans
E4664_16720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4664_16775	COG2951	lytic endotransglycosylase activity
E4664_16780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4664_16800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4664_16810	COG0671	phosphoesterase, PA-phosphatase related
E4664_16815	COG0861	Integral membrane protein TerC family
E4664_16825	COG0754	glutathionylspermidine amidase activity
E4664_16835	COG0402	S-adenosylhomocysteine deaminase activity
E4664_16850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4664_16855	COG1230	cation diffusion facilitator family transporter
E4664_16870	COG0706	membrane insertase activity
E4664_16885	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4664_16895	COG0592	DNA-directed DNA polymerase activity
E4664_16905	COG0187	DNA topoisomerase II activity
E4664_16915	COG0586	Pfam SNARE associated Golgi protein
E4664_16920	COG0488	(ABC) transporter
E4664_16945	COG0596	Alpha beta hydrolase
E4664_16950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4664_16955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4664_17000	COG0733	neurotransmitter:sodium symporter activity
E4664_17035	COG0583	DNA-binding transcription factor activity
E4664_17040	COG2233	PERMEase
E4664_17055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4664_17090	COG2814	Major facilitator Superfamily
E4664_17095	COG0656	L-ascorbic acid biosynthetic process
E4664_17100	COG0583	DNA-binding transcription factor activity
E4664_17115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4664_17120	COG1064	alcohol dehydrogenase
E4664_17125	COG2818	Glycosylase
E4664_17140	COG1194	a g-specific adenine glycosylase
E4664_17160	COG2983	Belongs to the UPF0260 family
E4664_17165	COG2133	pyrroloquinoline quinone binding
E4664_17170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4664_17175	COG2116	formate transmembrane transporter activity
E4664_17195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4664_17200	COG1335	isochorismatase
E4664_17205	COG0385	Bile acid
E4664_17210	COG0534	Mate efflux family protein
E4664_17215	COG1683	Conserved Protein
E4664_17235	COG0625	glutathione transferase activity
E4664_17245	COG1113	amino acid transport
E4664_17255	COG0523	cobalamin synthesis protein
E4664_17265	COG2188	Transcriptional regulator
E4664_17295	COG0010	Belongs to the arginase family
E4664_17310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4664_17375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4664_17385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4664_17390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4664_17480	COG0534	Mate efflux family protein
E4664_17485	COG0436	Aminotransferase
E4664_17490	COG2733	membrane
E4664_17505	COG2918	glutathione biosynthetic process
E4664_17515	COG3501	Rhs element vgr protein
E4664_17585	COG3150	esterase
E4664_17595	COG1028	Short-chain dehydrogenase reductase Sdr
E4664_17600	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4664_17610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4664_17620	COG2233	PERMEase
E4664_17625	COG2351	hydroxyisourate hydrolase activity
E4664_17660	COG3706	GGDEF domain
E4664_17675	COG1393	Belongs to the ArsC family
E4664_17680	COG0708	Exodeoxyribonuclease III
E4664_17705	COG0189	ligase activity
E4664_17725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4664_17735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4664_17750	COG4942	peptidase
E4664_17760	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4664_17770	COG2119	membrane
E4664_17775	COG4774	siderophore transport
E4664_17780	COG0426	domain, Protein
E4664_17780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4664_17805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4664_17825	COG1902	pentaerythritol trinitrate reductase activity
E4664_17830	COG1519	Transferase
E4664_17835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4664_17840	COG0668	transmembrane transport
E4664_17850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4664_17855	COG1335	isochorismatase
E4664_17860	COG1522	sequence-specific DNA binding
E4664_17885	COG0784	Response regulator, receiver
E4664_17885	COG2198	Histidine kinase
E4664_17885	COG2205	protein histidine kinase activity
E4664_17890	COG3162	membrane
E4664_17895	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4664_17905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4664_17915	COG3706	GGDEF domain
E4664_17920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4664_17925	COG1309	transcriptional regulator
E4664_17945	COG0352	thiamine-phosphate diphosphorylase activity
E4664_17945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4664_17945	COG0351	phosphomethylpyrimidine kinase
E4664_17955	COG2814	Major facilitator Superfamily
E4664_17980	COG1113	amino acid transport
E4664_17990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4664_17995	COG1012	belongs to the aldehyde dehydrogenase family
E4664_18005	COG1335	isochorismatase
E4664_18035	COG2814	Major facilitator Superfamily
E4664_18040	COG0583	DNA-binding transcription factor activity
E4664_18090	COG0667	Aldo Keto reductase
E4664_18115	COG1129	ABC transporter
E4664_18125	COG2207	Transcriptional regulator
E4664_18180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4664_18195	COG2329	Antibiotic biosynthesis monooxygenase
E4664_18210	COG1132	(ABC) transporter
E4664_18230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4664_18260	COG0427	acetyl-CoA hydrolase
E4664_18275	COG0745	RESPONSE REGULATOR receiver
E4664_18285	COG0659	secondary active sulfate transmembrane transporter activity
E4664_18290	COG4221	oxidoreductase activity
E4664_18300	COG0488	(ABC) transporter
E4664_18365	COG0833	amino acid
E4664_18410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4664_18415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4664_18430	COG2226	methyltransferase
E4664_18485	COG0493	'glutamate synthase
E4664_18495	COG1704	LemA family
E4664_18500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4664_18520	COG3307	-O-antigen
E4664_18540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4664_18555	COG0194	GDP metabolic process
E4664_18605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4664_18625	COG5380	lipid catabolic process
E4664_18630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4664_18655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4664_18660	COG0277	FAD linked oxidase domain protein
E4664_18670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4664_18675	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4664_18690	COG1289	transmembrane transporter activity
E4664_18700	COG0628	permease
E4664_18705	COG1192	Involved in chromosome partitioning
E4664_18735	COG0833	amino acid
E4664_18740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4664_18745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4664_18755	COG1012	belongs to the aldehyde dehydrogenase family
E4664_18795	COG0583	DNA-binding transcription factor activity
E4664_18850	COG0517	IMP dehydrogenase activity
E4664_18855	COG1983	PspC domain protein
E4664_18865	COG1960	acyl-CoA dehydrogenase activity
E4664_18880	COG0408	coproporphyrinogen oxidase activity
E4664_18900	COG0513	Belongs to the DEAD box helicase family
E4664_18910	COG1127	ABC transporter
E4664_18915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4664_18925	COG2854	intermembrane phospholipid transfer
E4664_18935	COG0598	Magnesium transport protein CorA
E4664_18945	COG0494	nUDIX hydrolase
E4664_18950	COG1040	competence protein
E4664_18955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4664_18975	COG1946	Acyl-CoA thioesterase
E4664_18980	COG1301	dicarboxylic acid transport
E4664_18995	COG1959	2 iron, 2 sulfur cluster binding
E4664_19000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4664_19000	COG1017	nitric oxide dioxygenase activity
E4664_19005	COG0433	COG0433 Predicted ATPase
E4664_19010	COG0626	cystathionine gamma-synthase activity
E4664_19130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4664_19140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4664_19165	COG1960	acyl-CoA dehydrogenase activity
E4664_19170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4664_19200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4664_19205	COG0339	signal peptide processing
E4664_19210	COG0557	exoribonuclease II activity
E4664_19255	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4664_19260	COG2169	Transcriptional regulator
E4664_19265	COG0697	spore germination
E4664_19270	COG1295	ribonuclease BN
E4664_19305	COG1702	phosphate starvation-inducible protein PhoH
E4664_19315	COG0739	heme binding
E4664_19315	COG0741	lytic transglycosylase activity
E4664_19315	COG1196	nuclear chromosome segregation
E4664_19345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4664_19350	COG1183	phosphatidylcholine synthase activity
E4664_19395	COG1960	acyl-CoA dehydrogenase activity
E4664_19415	COG2969	positive regulation of protein catabolic process
E4664_19425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4664_19435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4664_19440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4664_19445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4664_19465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4664_19475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4664_19480	COG1408	metallophosphoesterase
E4664_19490	COG2199	diguanylate cyclase activity
E4664_19535	COG3453	Protein conserved in bacteria
E4664_19535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4664_19550	COG1607	acyl-coa hydrolase
E4664_19580	COG2350	Protein conserved in bacteria
E4664_19590	COG0613	PHP domain protein
E4664_19595	COG3781	membrane
E4664_19605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4664_19610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4664_19620	COG1862	Preprotein translocase
E4664_19665	COG0629	single-stranded DNA binding
E4664_19730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4664_19830	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4664_19835	COG3657	addiction module killer protein
E4664_19865	COG3316	Transposase and inactivated derivatives
E4664_19880	COG2963	transposase activity
E4664_19935	COG3012	SEC-C Motif Domain Protein
E4664_19975	COG1570	exodeoxyribonuclease VII activity
E4664_20010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4664_20025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E4664_20040	COG1192	Involved in chromosome partitioning
E4664_20085	COG3316	Transposase and inactivated derivatives
E4664_20105	COG1660	Displays ATPase and GTPase activities
E4664_20110	COG3316	Transposase and inactivated derivatives
E4664_20125	COG3173	Aminoglycoside phosphotransferase
E4664_20140	COG3316	Transposase and inactivated derivatives
E4664_20165	COG1373	ATPase (AAA superfamily
E4664_20190	COG0582	viral genome integration into host DNA
E4664_20205	COG3316	Transposase and inactivated derivatives
E4664_20230	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4664_20265	COG2184	nucleotidyltransferase activity
E4664_20275	COG3316	Transposase and inactivated derivatives
E4664_20290	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E4664_20365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E4664_20375	COG3316	Transposase and inactivated derivatives
E4664_20395	COG2826	transposase and inactivated derivatives, IS30 family
E4664_20405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4664_20410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4664_20420	COG5002	protein histidine kinase activity
E4664_20425	COG0745	RESPONSE REGULATOR receiver
E4664_20440	COG3316	Transposase and inactivated derivatives
E4664_20485	COG1192	Involved in chromosome partitioning