locus-tag	class	description
KPZ59_00001	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KPZ59_00002	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KPZ59_00003	COG0596	Alpha beta hydrolase
KPZ59_00008	COG0488	(ABC) transporter
KPZ59_00009	COG0586	Pfam SNARE associated Golgi protein
KPZ59_00011	COG0187	DNA topoisomerase II activity
KPZ59_00013	COG0592	DNA-directed DNA polymerase activity
KPZ59_00018	COG0706	membrane insertase activity
KPZ59_00021	COG1230	cation diffusion facilitator family transporter
KPZ59_00022	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_00026	COG0402	S-adenosylhomocysteine deaminase activity
KPZ59_00028	COG0754	glutathionylspermidine amidase activity
KPZ59_00030	COG0861	Integral membrane protein TerC family
KPZ59_00031	COG0671	phosphoesterase, PA-phosphatase related
KPZ59_00033	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KPZ59_00036	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KPZ59_00037	COG2951	lytic endotransglycosylase activity
KPZ59_00043	COG0583	DNA-binding transcription factor activity
KPZ59_00047	COG0657	acetylesterase activity
KPZ59_00048	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KPZ59_00056	COG1047	Peptidyl-prolyl cis-trans
KPZ59_00058	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KPZ59_00059	COG0196	riboflavin kinase activity
KPZ59_00061	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KPZ59_00062	COG1309	transcriptional regulator
KPZ59_00063	COG1116	anion transmembrane transporter activity
KPZ59_00064	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_00065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_00066	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_00067	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_00071	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_00072	COG0546	phosphoglycolate phosphatase activity
KPZ59_00083	COG3023	N-Acetylmuramoyl-L-alanine amidase
KPZ59_00084	COG0728	peptidoglycan biosynthetic process
KPZ59_00089	COG1596	polysaccharide export
KPZ59_00090	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KPZ59_00092	COG1216	Glycosyl transferase, family 2
KPZ59_00092	COG1442	glycosyl transferase family 8
KPZ59_00094	COG1216	Glycosyl transferase, family 2
KPZ59_00096	COG1216	Glycosyl transferase, family 2
KPZ59_00097	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KPZ59_00098	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KPZ59_00101	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KPZ59_00103	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KPZ59_00105	COG2186	Transcriptional regulator
KPZ59_00107	COG0277	FAD linked oxidase domain protein
KPZ59_00108	COG1448	Aminotransferase
KPZ59_00109	COG1802	Transcriptional regulator
KPZ59_00112	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KPZ59_00131	COG0564	pseudouridine synthase activity
KPZ59_00139	COG0251	oxidation-reduction process
KPZ59_00140	COG1113	amino acid transport
KPZ59_00141	COG1113	amino acid transport
KPZ59_00145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPZ59_00146	COG1960	acyl-CoA dehydrogenase activity
KPZ59_00147	COG1024	Enoyl-CoA hydratase
KPZ59_00148	COG1024	Enoyl-CoA hydratase
KPZ59_00149	COG0477	Major facilitator Superfamily
KPZ59_00150	COG3916	Acyl-homoserine-lactone synthase
KPZ59_00152	COG2197	response regulator
KPZ59_00154	COG1960	acyl-CoA dehydrogenase activity
KPZ59_00155	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KPZ59_00155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KPZ59_00155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KPZ59_00155	COG3321	synthase
KPZ59_00163	COG0271	Belongs to the BolA IbaG family
KPZ59_00165	COG1192	Involved in chromosome partitioning
KPZ59_00168	COG0586	Pfam SNARE associated Golgi protein
KPZ59_00169	COG2259	Doxx family
KPZ59_00170	COG4399	Belongs to the UPF0754 family
KPZ59_00171	COG0519	Catalyzes the synthesis of GMP from XMP
KPZ59_00171	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KPZ59_00180	COG0281	malic enzyme
KPZ59_00181	COG2837	iron assimilation
KPZ59_00182	COG1280	lysine exporter protein (LysE YggA)
KPZ59_00183	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KPZ59_00184	COG1121	(ABC) transporter
KPZ59_00197	COG0386	Belongs to the glutathione peroxidase family
KPZ59_00200	COG1309	transcriptional regulator
KPZ59_00201	COG0697	spore germination
KPZ59_00203	COG0758	DNA mediated transformation
KPZ59_00210	COG1309	transcriptional regulator
KPZ59_00217	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KPZ59_00219	COG0655	NAD(P)H dehydrogenase (quinone) activity
KPZ59_00227	COG4452	Inner membrane protein CreD
KPZ59_00228	COG2205	protein histidine kinase activity
KPZ59_00229	COG0745	RESPONSE REGULATOR receiver
KPZ59_00230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_00232	COG0477	Major facilitator Superfamily
KPZ59_00234	COG1253	flavin adenine dinucleotide binding
KPZ59_00235	COG3012	SEC-C Motif Domain Protein
KPZ59_00236	COG2860	membrane
KPZ59_00237	COG0477	Major facilitator Superfamily
KPZ59_00239	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_00242	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KPZ59_00245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_00247	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_00248	COG0606	chelatase, subunit chli
KPZ59_00250	COG0347	Belongs to the P(II) protein family
KPZ59_00251	COG0004	ammonium transporteR
KPZ59_00253	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KPZ59_00253	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KPZ59_00261	COG0795	lipopolysaccharide-transporting ATPase activity
KPZ59_00262	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KPZ59_00263	COG0793	Belongs to the peptidase S41A family
KPZ59_00266	COG2197	response regulator
KPZ59_00268	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KPZ59_00270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_00271	COG4974	Belongs to the 'phage' integrase family
KPZ59_00276	COG0772	Belongs to the SEDS family
KPZ59_00277	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KPZ59_00278	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KPZ59_00280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KPZ59_00285	COG0697	spore germination
KPZ59_00286	COG1538	Outer membrane efflux protein
KPZ59_00290	COG3275	phosphorelay sensor kinase activity
KPZ59_00292	COG0181	hydroxymethylbilane synthase activity
KPZ59_00301	COG1716	ATPase activity
KPZ59_00302	COG0546	phosphoglycolate phosphatase activity
KPZ59_00322	COG2056	Na+-H+ antiporter family
KPZ59_00325	COG0326	Molecular chaperone. Has ATPase activity
KPZ59_00328	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KPZ59_00341	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KPZ59_00342	COG2169	Transcriptional regulator
KPZ59_00342	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KPZ59_00348	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KPZ59_00350	COG0497	DNA recombination
KPZ59_00353	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KPZ59_00355	COG0237	dephospho-CoA kinase activity
KPZ59_00365	COG0195	Participates in both transcription termination and antitermination
KPZ59_00368	COG1320	monovalent cation:proton antiporter activity
KPZ59_00369	COG2212	antiporter activity
KPZ59_00370	COG1863	multisubunit Na H antiporter MnhE subunit
KPZ59_00371	COG0651	ATP synthesis coupled electron transport
KPZ59_00372	COG1006	Multisubunit Na H antiporter MnhC subunit
KPZ59_00373	COG2111	Na H antiporter
KPZ59_00373	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KPZ59_00376	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KPZ59_00379	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_00382	COG2226	methyltransferase
KPZ59_00386	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KPZ59_00387	COG1074	ATP-dependent DNA helicase activity
KPZ59_00388	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPZ59_00389	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KPZ59_00392	COG0598	Magnesium transport protein CorA
KPZ59_00393	COG0789	Transcriptional regulator
KPZ59_00394	COG0484	heat shock protein binding
KPZ59_00397	COG0475	glutathione-regulated potassium exporter activity
KPZ59_00397	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPZ59_00398	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KPZ59_00402	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPZ59_00404	COG4535	Mg2 and Co2 transporter CorC
KPZ59_00405	COG0425	Belongs to the sulfur carrier protein TusA family
KPZ59_00407	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KPZ59_00407	COG0644	oxidoreductase
KPZ59_00409	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KPZ59_00412	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPZ59_00413	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KPZ59_00415	COG0493	'glutamate synthase
KPZ59_00415	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPZ59_00420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KPZ59_00423	COG0534	Mate efflux family protein
KPZ59_00425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KPZ59_00426	COG4221	oxidoreductase activity
KPZ59_00427	COG0583	DNA-binding transcription factor activity
KPZ59_00430	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_00431	COG1530	ribonuclease E activity
KPZ59_00434	COG0546	phosphoglycolate phosphatase activity
KPZ59_00435	COG2378	regulation of single-species biofilm formation
KPZ59_00436	COG0625	glutathione transferase activity
KPZ59_00438	COG0583	DNA-binding transcription factor activity
KPZ59_00449	COG0473	3-isopropylmalate dehydrogenase activity
KPZ59_00460	COG1301	dicarboxylic acid transport
KPZ59_00462	COG1560	Kdo2-lipid A biosynthetic process
KPZ59_00463	COG1280	lysine exporter protein (LysE YggA)
KPZ59_00467	COG0488	(ABC) transporter
KPZ59_00468	COG2900	Belongs to the SlyX family
KPZ59_00470	COG1733	regulation of RNA biosynthetic process
KPZ59_00475	COG0210	DNA helicase
KPZ59_00476	COG0724	RNA recognition motif
KPZ59_00480	COG4651	solute:proton antiporter activity
KPZ59_00480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPZ59_00485	COG0788	formyltetrahydrofolate deformylase activity
KPZ59_00508	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPZ59_00508	COG2813	Specifically methylates the guanine in position
KPZ59_00510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KPZ59_00512	COG4774	siderophore transport
KPZ59_00514	COG0740	serine-type endopeptidase activity
KPZ59_00518	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KPZ59_00518	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KPZ59_00519	COG0280	phosphate acetyltransferase
KPZ59_00519	COG0857	belongs to the CobB CobQ family
KPZ59_00520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KPZ59_00522	COG0800	Aldolase
KPZ59_00524	COG3265	gluconokinase activity
KPZ59_00525	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_00527	COG2267	carboxylic ester hydrolase activity
KPZ59_00530	COG0793	Belongs to the peptidase S41A family
KPZ59_00537	COG1426	Protein conserved in bacteria
KPZ59_00545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KPZ59_00547	COG1162	GTPase activity
KPZ59_00548	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KPZ59_00551	COG1538	Outer membrane efflux protein
KPZ59_00552	COG0577	efflux transmembrane transporter activity
KPZ59_00552	COG1136	(ABC) transporter
KPZ59_00553	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_00558	COG0028	Belongs to the TPP enzyme family
KPZ59_00559	COG0440	acetolactate synthase activity
KPZ59_00570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KPZ59_00573	COG0084	hydrolase, TatD family'
KPZ59_00576	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KPZ59_00578	COG0583	DNA-binding transcription factor activity
KPZ59_00580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KPZ59_00598	COG2205	protein histidine kinase activity
KPZ59_00601	COG2132	Multicopper oxidase
KPZ59_00602	COG2132	Multicopper oxidase
KPZ59_00604	COG0789	Transcriptional regulator
KPZ59_00611	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPZ59_00614	COG0640	Transcriptional regulator
KPZ59_00616	COG0798	PFAM Bile acid sodium symporter
KPZ59_00617	COG0431	NADPH-dependent FMN reductase
KPZ59_00620	COG2814	Major facilitator Superfamily
KPZ59_00622	COG0697	spore germination
KPZ59_00628	COG3622	Belongs to the hyi family
KPZ59_00629	COG2084	Dehydrogenase
KPZ59_00630	COG1024	Enoyl-CoA hydratase
KPZ59_00631	COG2205	protein histidine kinase activity
KPZ59_00631	COG0784	Response regulator, receiver
KPZ59_00631	COG5002	protein histidine kinase activity
KPZ59_00635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KPZ59_00637	COG3956	TIGRFAM MazG family protein
KPZ59_00638	COG1555	photosystem II stabilization
KPZ59_00639	COG0617	tRNA 3'-terminal CCA addition
KPZ59_00640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KPZ59_00644	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KPZ59_00645	COG3028	Belongs to the UPF0307 family
KPZ59_00646	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_00649	COG0625	glutathione transferase activity
KPZ59_00650	COG1238	metal cluster binding
KPZ59_00658	COG0072	phenylalanine-tRNA ligase activity
KPZ59_00663	COG0248	Ppx GppA phosphatase
KPZ59_00665	COG0037	tRNA processing
KPZ59_00673	COG1764	response to oxidative stress
KPZ59_00674	COG1846	Transcriptional regulator
KPZ59_00676	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPZ59_00688	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KPZ59_00689	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KPZ59_00690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KPZ59_00692	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KPZ59_00695	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_00704	COG1214	PFAM Peptidase M22, glycoprotease
KPZ59_00707	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KPZ59_00709	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KPZ59_00710	COG0561	phosphatase activity
KPZ59_00712	COG2132	Multicopper oxidase
KPZ59_00716	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KPZ59_00717	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KPZ59_00718	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KPZ59_00724	COG1063	alcohol dehydrogenase
KPZ59_00725	COG0583	DNA-binding transcription factor activity
KPZ59_00726	COG1960	acyl-CoA dehydrogenase activity
KPZ59_00727	COG2814	Major facilitator Superfamily
KPZ59_00728	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KPZ59_00730	COG1053	succinate dehydrogenase
KPZ59_00731	COG0583	DNA-binding transcription factor activity
KPZ59_00734	COG0583	DNA-binding transcription factor activity
KPZ59_00740	COG0583	DNA-binding transcription factor activity
KPZ59_00743	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_00745	COG1309	transcriptional regulator
KPZ59_00749	COG0384	phenazine biosynthesis protein PhzF
KPZ59_00751	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KPZ59_00754	COG0745	RESPONSE REGULATOR receiver
KPZ59_00762	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KPZ59_00768	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KPZ59_00769	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KPZ59_00773	COG0583	DNA-binding transcription factor activity
KPZ59_00777	COG0668	transmembrane transport
KPZ59_00779	COG2081	HI0933 family
KPZ59_00780	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KPZ59_00786	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPZ59_00786	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPZ59_00788	COG0489	protein tyrosine kinase activity
KPZ59_00799	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KPZ59_00801	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KPZ59_00804	COG0730	response to heat
KPZ59_00806	COG1196	nuclear chromosome segregation
KPZ59_00810	COG2223	nitrite transmembrane transporter activity
KPZ59_00811	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KPZ59_00812	COG1877	trehalose-phosphatase activity
KPZ59_00813	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPZ59_00813	COG2226	methyltransferase
KPZ59_00813	COG0596	Alpha beta hydrolase
KPZ59_00816	COG4106	trans-aconitate 2-methyltransferase activity
KPZ59_00819	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KPZ59_00820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KPZ59_00821	COG0009	L-threonylcarbamoyladenylate synthase
KPZ59_00822	COG3101	peptidyl-lysine hydroxylation
KPZ59_00823	COG1399	metal-binding, possibly nucleic acid-binding protein
KPZ59_00828	COG1652	LysM domain
KPZ59_00829	COG0351	phosphomethylpyrimidine kinase
KPZ59_00829	COG0352	thiamine-phosphate diphosphorylase activity
KPZ59_00829	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KPZ59_00831	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KPZ59_00837	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KPZ59_00842	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KPZ59_00845	COG0358	DNA primase activity
KPZ59_00847	COG0564	pseudouridine synthase activity
KPZ59_00860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_00873	COG0305	Participates in initiation and elongation during chromosome replication
KPZ59_00890	COG5410	chromosome segregation
KPZ59_00891	COG3567	Phage-associated protein, HI1409 family
KPZ59_00897	COG3566	protein conserved in bacteria
KPZ59_00921	COG0582	viral genome integration into host DNA
KPZ59_00923	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPZ59_00926	COG0583	DNA-binding transcription factor activity
KPZ59_00927	COG0473	3-isopropylmalate dehydrogenase activity
KPZ59_00929	COG0657	acetylesterase activity
KPZ59_00931	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_00935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KPZ59_00935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPZ59_00938	COG1981	membrane
KPZ59_00947	COG0456	acetyltransferase
KPZ59_00949	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KPZ59_00950	COG0492	ferredoxin-NADP+ reductase activity
KPZ59_00951	COG1674	ftsk spoiiie
KPZ59_00951	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KPZ59_00952	COG1280	lysine exporter protein (LysE YggA)
KPZ59_00956	COG2894	cell division
KPZ59_00959	COG0204	Acyl-transferase
KPZ59_00960	COG2885	chlorophyll binding
KPZ59_00961	COG0210	DNA helicase
KPZ59_00963	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KPZ59_00966	COG0121	glutamine amidotransferase
KPZ59_00970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KPZ59_00971	COG0735	belongs to the Fur family
KPZ59_00976	COG0420	3'-5' exonuclease activity
KPZ59_00980	COG1090	epimerase
KPZ59_00983	COG2050	protein possibly involved in aromatic compounds catabolism
KPZ59_00985	COG2814	Major facilitator Superfamily
KPZ59_00986	COG0405	Gamma-glutamyltransferase
KPZ59_01002	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KPZ59_01004	COG0477	Major facilitator Superfamily
KPZ59_01005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_01007	COG1595	DNA-templated transcription, initiation
KPZ59_01018	COG0531	amino acid
KPZ59_01019	COG2040	homocysteine
KPZ59_01024	COG1309	transcriptional regulator
KPZ59_01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KPZ59_01026	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KPZ59_01028	COG1607	acyl-coa hydrolase
KPZ59_01030	COG0523	cobalamin synthesis protein
KPZ59_01032	COG4681	YaeQ
KPZ59_01034	COG0726	polysaccharide deacetylase
KPZ59_01034	COG1649	PFAM Uncharacterised BCR, COG1649
KPZ59_01035	COG1215	transferase activity, transferring glycosyl groups
KPZ59_01037	COG1024	Enoyl-CoA hydratase
KPZ59_01040	COG1414	Transcriptional regulator
KPZ59_01044	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01047	COG2271	Major facilitator Superfamily
KPZ59_01049	COG2267	carboxylic ester hydrolase activity
KPZ59_01050	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01053	COG0028	Belongs to the TPP enzyme family
KPZ59_01055	COG0477	Major facilitator Superfamily
KPZ59_01056	COG0242	peptide deformylase activity
KPZ59_01057	COG2066	Belongs to the glutaminase family
KPZ59_01058	COG2207	Transcriptional regulator
KPZ59_01059	COG2223	nitrite transmembrane transporter activity
KPZ59_01062	COG0583	DNA-binding transcription factor activity
KPZ59_01063	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01064	COG2271	Major facilitator Superfamily
KPZ59_01065	COG3959	Transketolase, thiamine diphosphate binding domain
KPZ59_01066	COG3958	Transketolase
KPZ59_01069	COG0306	phosphate transporter
KPZ59_01073	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPZ59_01082	COG4181	ATPase activity
KPZ59_01083	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KPZ59_01088	COG0583	DNA-binding transcription factor activity
KPZ59_01090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_01091	COG1773	rubredoxin
KPZ59_01100	COG2851	Citrate transporter
KPZ59_01101	COG1253	flavin adenine dinucleotide binding
KPZ59_01109	COG0804	urea catabolic process
KPZ59_01111	COG0830	nickel cation binding
KPZ59_01114	COG0742	ribosomal rna small subunit methyltransferase
KPZ59_01115	COG0768	penicillin binding
KPZ59_01119	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KPZ59_01120	COG2878	Part of a membrane complex involved in electron transport
KPZ59_01121	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KPZ59_01123	COG3384	dioxygenase
KPZ59_01127	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KPZ59_01133	COG0006	proline dipeptidase activity
KPZ59_01134	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_01135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_01139	COG1279	arginine transmembrane transporter activity
KPZ59_01140	COG0583	DNA-binding transcription factor activity
KPZ59_01148	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_01149	COG0741	lytic transglycosylase activity
KPZ59_01149	COG1388	LysM domain
KPZ59_01149	COG0741	lytic transglycosylase activity
KPZ59_01149	COG1388	LysM domain
KPZ59_01151	COG4174	ABC transporter (Permease)
KPZ59_01152	COG4239	(ABC) transporter, permease
KPZ59_01153	COG4172	Belongs to the ABC transporter superfamily
KPZ59_01157	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_01159	COG2203	Gaf domain
KPZ59_01159	COG3706	GGDEF domain
KPZ59_01159	COG4251	negative regulation of phosphorylation
KPZ59_01159	COG5001	Diguanylate cyclase
KPZ59_01162	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPZ59_01162	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_01167	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPZ59_01169	COG0583	DNA-binding transcription factor activity
KPZ59_01170	COG2814	Major facilitator Superfamily
KPZ59_01173	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01174	COG1454	alcohol dehydrogenase
KPZ59_01175	COG3485	protocatechuate 3,4-dioxygenase
KPZ59_01178	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_01179	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_01180	COG0183	Belongs to the thiolase family
KPZ59_01187	COG1113	amino acid transport
KPZ59_01189	COG0531	amino acid
KPZ59_01193	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01197	COG3138	arginine N-succinyltransferase
KPZ59_01198	COG1113	amino acid transport
KPZ59_01201	COG0697	spore germination
KPZ59_01202	COG2721	sulfolactate sulfo-lyase activity
KPZ59_01203	COG2271	Major facilitator Superfamily
KPZ59_01204	COG4948	Mandelate Racemase Muconate Lactonizing
KPZ59_01206	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01207	COG2186	Transcriptional regulator
KPZ59_01212	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01214	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01215	COG1024	Enoyl-CoA hydratase
KPZ59_01216	COG2814	Major facilitator Superfamily
KPZ59_01219	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_01222	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPZ59_01230	COG2207	Transcriptional regulator
KPZ59_01231	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KPZ59_01232	COG2072	flavoprotein involved in K transport
KPZ59_01233	COG0300	oxidoreductase activity
KPZ59_01235	COG1309	transcriptional regulator
KPZ59_01236	COG1741	Belongs to the pirin family
KPZ59_01239	COG2072	flavoprotein involved in K transport
KPZ59_01241	COG2252	PERMEase
KPZ59_01242	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KPZ59_01243	COG3038	cytochrome b561
KPZ59_01245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KPZ59_01247	COG0527	aspartate kinase activity
KPZ59_01286	COG5410	chromosome segregation
KPZ59_01330	COG0582	viral genome integration into host DNA
KPZ59_01332	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KPZ59_01334	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KPZ59_01337	COG0667	Aldo Keto reductase
KPZ59_01339	COG1765	OsmC-like protein
KPZ59_01342	COG0542	response to heat
KPZ59_01349	COG2885	chlorophyll binding
KPZ59_01351	COG0625	glutathione transferase activity
KPZ59_01352	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KPZ59_01356	COG3634	alkyl hydroperoxide reductase activity
KPZ59_01358	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KPZ59_01360	COG0450	alkyl hydroperoxide reductase
KPZ59_01361	COG1643	Atp-dependent helicase
KPZ59_01364	COG2814	Major facilitator Superfamily
KPZ59_01365	COG3135	benzoate transporter
KPZ59_01366	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01367	COG0633	Ferredoxin
KPZ59_01367	COG0543	2 iron, 2 sulfur cluster binding
KPZ59_01368	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KPZ59_01369	COG4638	Rieske (2fe-2S)
KPZ59_01370	COG0583	DNA-binding transcription factor activity
KPZ59_01372	COG2871	sodium ion transport
KPZ59_01388	COG1570	exodeoxyribonuclease VII activity
KPZ59_01395	COG1280	lysine exporter protein (LysE YggA)
KPZ59_01396	COG1278	Cold shock
KPZ59_01402	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_01405	COG2814	Major facilitator Superfamily
KPZ59_01419	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KPZ59_01421	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KPZ59_01422	COG1137	ATPase activity
KPZ59_01423	COG1538	Outer membrane efflux protein
KPZ59_01429	COG4122	O-methyltransferase activity
KPZ59_01432	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KPZ59_01435	COG1522	sequence-specific DNA binding
KPZ59_01436	COG5006	permease, DMT superfamily
KPZ59_01438	COG1560	Kdo2-lipid A biosynthetic process
KPZ59_01439	COG0598	Magnesium transport protein CorA
KPZ59_01444	COG2814	Major facilitator Superfamily
KPZ59_01448	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPZ59_01453	COG0583	DNA-binding transcription factor activity
KPZ59_01454	COG1914	H( )-stimulated, divalent metal cation uptake system
KPZ59_01458	COG4770	biotin carboxylase activity
KPZ59_01459	COG0038	chloride channel
KPZ59_01460	COG2831	hemolysin activation secretion protein
KPZ59_01461	COG3210	domain, Protein
KPZ59_01463	COG1309	transcriptional regulator
KPZ59_01465	COG1063	alcohol dehydrogenase
KPZ59_01468	COG0439	Biotin carboxylase
KPZ59_01469	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_01470	COG1733	regulation of RNA biosynthetic process
KPZ59_01473	COG0864	Transcriptional regulator
KPZ59_01475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPZ59_01476	COG1116	anion transmembrane transporter activity
KPZ59_01509	COG0590	tRNA wobble adenosine to inosine editing
KPZ59_01510	COG2807	transmembrane transport
KPZ59_01513	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KPZ59_01515	COG0789	Transcriptional regulator
KPZ59_01518	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_01522	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KPZ59_01527	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01528	COG0531	amino acid
KPZ59_01529	COG1760	l-serine dehydratase
KPZ59_01530	COG2030	dehydratase
KPZ59_01530	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01531	COG3396	Phenylacetate-CoA oxygenase
KPZ59_01532	COG3460	Phenylacetate-CoA oxygenase
KPZ59_01533	COG3396	Phenylacetate-CoA oxygenase
KPZ59_01534	COG2151	metal-sulfur cluster biosynthetic enzyme
KPZ59_01535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_01536	COG1024	Enoyl-CoA hydratase
KPZ59_01537	COG1024	Enoyl-CoA hydratase
KPZ59_01538	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPZ59_01539	COG0183	Belongs to the thiolase family
KPZ59_01540	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KPZ59_01541	COG3327	negative regulation of DNA-templated transcription, initiation
KPZ59_01543	COG2050	protein possibly involved in aromatic compounds catabolism
KPZ59_01545	COG0556	nucleotide-excision repair
KPZ59_01552	COG2207	Transcriptional regulator
KPZ59_01556	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KPZ59_01557	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KPZ59_01558	COG2271	Major facilitator Superfamily
KPZ59_01559	COG0753	catalase activity
KPZ59_01560	COG3038	cytochrome b561
KPZ59_01564	COG2267	carboxylic ester hydrolase activity
KPZ59_01565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_01566	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_01567	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01568	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KPZ59_01570	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_01571	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPZ59_01572	COG0583	DNA-binding transcription factor activity
KPZ59_01574	COG1414	Transcriptional regulator
KPZ59_01575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_01577	COG1840	ABC-type Fe3 transport system, periplasmic component
KPZ59_01578	COG3842	ATPase activity
KPZ59_01581	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KPZ59_01582	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KPZ59_01583	COG2814	Major facilitator Superfamily
KPZ59_01584	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01587	COG1024	Enoyl-CoA hydratase
KPZ59_01589	COG2814	Major facilitator Superfamily
KPZ59_01591	COG0183	Belongs to the thiolase family
KPZ59_01592	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPZ59_01593	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01594	COG1024	Enoyl-CoA hydratase
KPZ59_01595	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01596	COG2814	Major facilitator Superfamily
KPZ59_01597	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_01598	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_01600	COG2814	Major facilitator Superfamily
KPZ59_01602	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01605	COG0583	DNA-binding transcription factor activity
KPZ59_01607	COG4770	biotin carboxylase activity
KPZ59_01608	COG1024	Enoyl-CoA hydratase
KPZ59_01609	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KPZ59_01610	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01611	COG1309	transcriptional regulator
KPZ59_01612	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_01616	COG0583	DNA-binding transcription factor activity
KPZ59_01628	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01632	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KPZ59_01636	COG0784	Response regulator, receiver
KPZ59_01636	COG2205	protein histidine kinase activity
KPZ59_01643	COG0765	amino acid transport
KPZ59_01644	COG0765	amino acid transport
KPZ59_01646	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPZ59_01647	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPZ59_01649	COG1280	lysine exporter protein (LysE YggA)
KPZ59_01650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KPZ59_01651	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPZ59_01652	COG1045	serine acetyltransferase
KPZ59_01655	COG0583	DNA-binding transcription factor activity
KPZ59_01656	COG0625	glutathione transferase activity
KPZ59_01657	COG0625	glutathione transferase activity
KPZ59_01658	COG0583	DNA-binding transcription factor activity
KPZ59_01660	COG1346	cytolysis
KPZ59_01665	COG0300	oxidoreductase activity
KPZ59_01667	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KPZ59_01668	COG3052	prosthetic group binding
KPZ59_01672	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KPZ59_01676	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_01678	COG1294	oxidase, subunit
KPZ59_01679	COG1271	oxidase subunit
KPZ59_01684	COG0477	Major facilitator Superfamily
KPZ59_01686	COG4521	taurine ABC transporter
KPZ59_01687	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KPZ59_01688	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_01689	COG2175	clavaminate synthase activity
KPZ59_01691	COG1953	Uracil, thiamine, allantoin
KPZ59_01693	COG0583	DNA-binding transcription factor activity
KPZ59_01695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KPZ59_01698	COG0640	Transcriptional regulator
KPZ59_01699	COG0798	PFAM Bile acid sodium symporter
KPZ59_01700	COG0583	DNA-binding transcription factor activity
KPZ59_01703	COG3634	alkyl hydroperoxide reductase activity
KPZ59_01711	COG0436	Aminotransferase
KPZ59_01713	COG0386	Belongs to the glutathione peroxidase family
KPZ59_01721	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KPZ59_01726	COG0012	GTP binding
KPZ59_01727	COG2011	ABC-type metal ion transport system permease component
KPZ59_01728	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KPZ59_01730	COG1464	Belongs to the NlpA lipoprotein family
KPZ59_01736	COG0765	amino acid transport
KPZ59_01737	COG0765	amino acid transport
KPZ59_01738	COG1126	abc transporter atp-binding protein
KPZ59_01740	COG1522	sequence-specific DNA binding
KPZ59_01743	COG1309	transcriptional regulator
KPZ59_01748	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_01751	COG0583	DNA-binding transcription factor activity
KPZ59_01753	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KPZ59_01755	COG0697	spore germination
KPZ59_01760	COG3121	Chaperone
KPZ59_01761	COG3539	Fimbrial protein
KPZ59_01766	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KPZ59_01766	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KPZ59_01775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KPZ59_01777	COG2353	YceI-like domain
KPZ59_01779	COG3698	Phosphodiester glycosidase
KPZ59_01782	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KPZ59_01783	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KPZ59_01783	COG0506	proline dehydrogenase activity
KPZ59_01783	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KPZ59_01785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KPZ59_01786	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KPZ59_01790	COG1132	(ABC) transporter
KPZ59_01791	COG3122	Protein conserved in bacteria
KPZ59_01792	COG3619	membrane
KPZ59_01795	COG0640	Transcriptional regulator
KPZ59_01797	COG2850	peptidyl-arginine hydroxylation
KPZ59_01798	COG0424	maF-like protein
KPZ59_01802	COG0191	fructose-bisphosphate aldolase activity
KPZ59_01803	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KPZ59_01806	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KPZ59_01808	COG1192	Involved in chromosome partitioning
KPZ59_01809	COG1475	DNA binding
KPZ59_01810	COG0811	peptide transport
KPZ59_01812	COG1132	(ABC) transporter
KPZ59_01813	COG1663	tetraacyldisaccharide 4'-kinase activity
KPZ59_01817	COG0084	hydrolase, TatD family'
KPZ59_01830	COG0776	regulation of translation
KPZ59_01836	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KPZ59_01837	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KPZ59_01845	COG4166	transmembrane transport
KPZ59_01847	COG0339	signal peptide processing
KPZ59_01849	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KPZ59_01856	COG0702	epimerase
KPZ59_01857	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KPZ59_01861	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KPZ59_01867	COG0316	Belongs to the HesB IscA family
KPZ59_01868	COG0822	iron-sulfur transferase activity
KPZ59_01873	COG0776	regulation of translation
KPZ59_01874	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KPZ59_01875	COG2207	Transcriptional regulator
KPZ59_01876	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPZ59_01877	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01878	COG1960	acyl-CoA dehydrogenase activity
KPZ59_01881	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KPZ59_01885	COG4264	IucA IucC family
KPZ59_01886	COG4264	IucA IucC family
KPZ59_01888	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KPZ59_01894	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KPZ59_01897	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KPZ59_01898	COG0406	alpha-ribazole phosphatase activity
KPZ59_01901	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KPZ59_01902	COG0730	response to heat
KPZ59_01906	COG4773	Receptor
KPZ59_01907	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPZ59_01910	COG1131	(ABC) transporter
KPZ59_01911	COG0842	Transport permease protein
KPZ59_01912	COG0842	Transport permease protein
KPZ59_01923	COG2226	methyltransferase
KPZ59_01928	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KPZ59_01935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KPZ59_01937	COG0133	tryptophan synthase activity
KPZ59_01940	COG3706	GGDEF domain
KPZ59_01943	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KPZ59_01944	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KPZ59_01945	COG0022	dehydrogenase e1 component
KPZ59_01946	COG0508	dehydrogenase complex catalyzes the overall conversion of
KPZ59_01947	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPZ59_01949	COG1063	alcohol dehydrogenase
KPZ59_01950	COG3781	membrane
KPZ59_01952	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPZ59_01952	COG3453	Protein conserved in bacteria
KPZ59_01954	COG0730	response to heat
KPZ59_01957	COG2207	Transcriptional regulator
KPZ59_01957	COG3708	Transcriptional regulator
KPZ59_01958	COG1733	regulation of RNA biosynthetic process
KPZ59_01959	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KPZ59_01961	COG2188	Transcriptional regulator
KPZ59_01964	COG4521	taurine ABC transporter
KPZ59_01966	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_01970	COG0477	Major facilitator Superfamily
KPZ59_01972	COG1027	Aspartate ammonia-lyase
KPZ59_01975	COG0583	DNA-binding transcription factor activity
KPZ59_01976	COG0583	DNA-binding transcription factor activity
KPZ59_01977	COG0183	Belongs to the thiolase family
KPZ59_01978	COG2031	fatty acid transporter
KPZ59_01981	COG0583	DNA-binding transcription factor activity
KPZ59_01985	COG1309	transcriptional regulator
KPZ59_01987	COG2610	gluconate transmembrane transporter activity
KPZ59_01988	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01989	COG2207	Transcriptional regulator
KPZ59_01992	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_01994	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_01998	COG0543	2 iron, 2 sulfur cluster binding
KPZ59_01998	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_01999	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KPZ59_02000	COG4638	Rieske (2fe-2S)
KPZ59_02002	COG0725	ABC transporter, periplasmic molybdate-binding protein
KPZ59_02003	COG4149	molybdate abc transporter
KPZ59_02004	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KPZ59_02005	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_02006	COG3433	isochorismatase activity
KPZ59_02006	COG1535	isochorismatase
KPZ59_02018	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KPZ59_02021	COG0753	catalase activity
KPZ59_02023	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KPZ59_02027	COG3539	Fimbrial protein
KPZ59_02032	COG0747	negative chemotaxis
KPZ59_02033	COG0601	transmembrane transport
KPZ59_02034	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KPZ59_02038	COG1132	(ABC) transporter
KPZ59_02039	COG1132	(ABC) transporter
KPZ59_02042	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_02045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KPZ59_02048	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_02049	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_02050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_02051	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_02057	COG4771	TonB-dependent receptor
KPZ59_02058	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_02061	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPZ59_02062	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_02063	COG0745	RESPONSE REGULATOR receiver
KPZ59_02064	COG2205	protein histidine kinase activity
KPZ59_02066	COG2207	Transcriptional regulator
KPZ59_02069	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_02076	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KPZ59_02087	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KPZ59_02091	COG1120	ATPase activity
KPZ59_02092	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KPZ59_02095	COG1064	alcohol dehydrogenase
KPZ59_02098	COG2207	Transcriptional regulator
KPZ59_02099	COG2084	Dehydrogenase
KPZ59_02101	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KPZ59_02102	COG0583	DNA-binding transcription factor activity
KPZ59_02104	COG0129	dihydroxy-acid dehydratase activity
KPZ59_02105	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_02108	COG1566	PFAM secretion protein HlyD family protein
KPZ59_02110	COG2271	Major facilitator Superfamily
KPZ59_02113	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_02118	COG0583	DNA-binding transcription factor activity
KPZ59_02121	COG2188	Transcriptional regulator
KPZ59_02126	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_02129	COG3162	membrane
KPZ59_02131	COG3829	transcription factor binding
KPZ59_02132	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_02133	COG1960	acyl-CoA dehydrogenase activity
KPZ59_02136	COG3231	kanamycin kinase activity
KPZ59_02137	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_02141	COG2186	Transcriptional regulator
KPZ59_02143	COG0583	DNA-binding transcription factor activity
KPZ59_02144	COG4948	Mandelate Racemase Muconate Lactonizing
KPZ59_02145	COG4829	muconolactone delta-isomerase
KPZ59_02147	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_02148	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_02149	COG0183	Belongs to the thiolase family
KPZ59_02150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPZ59_02151	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_02153	COG3733	amine oxidase
KPZ59_02155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_02157	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_02159	COG4638	Rieske (2fe-2S)
KPZ59_02163	COG0154	amidase activity
KPZ59_02166	COG2814	Major facilitator Superfamily
KPZ59_02171	COG1960	acyl-CoA dehydrogenase activity
KPZ59_02172	COG0583	DNA-binding transcription factor activity
KPZ59_02173	COG1414	Transcriptional regulator
KPZ59_02176	COG2391	methyltransferase activity
KPZ59_02178	COG4993	Dehydrogenase
KPZ59_02179	COG3659	wide pore channel activity
KPZ59_02180	COG3420	alginic acid biosynthetic process
KPZ59_02181	COG0710	3-dehydroquinate dehydratase activity
KPZ59_02182	COG3485	protocatechuate 3,4-dioxygenase
KPZ59_02183	COG3485	protocatechuate 3,4-dioxygenase
KPZ59_02184	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPZ59_02185	COG2271	Major facilitator Superfamily
KPZ59_02186	COG0596	Alpha beta hydrolase
KPZ59_02187	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KPZ59_02188	COG0183	Belongs to the thiolase family
KPZ59_02189	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_02190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_02192	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KPZ59_02193	COG2323	membrane
KPZ59_02202	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_02202	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPZ59_02207	COG0542	response to heat
KPZ59_02208	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KPZ59_02214	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KPZ59_02215	COG0569	domain protein
KPZ59_02216	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KPZ59_02219	COG4774	siderophore transport
KPZ59_02220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPZ59_02222	COG1585	Membrane protein implicated in regulation of membrane protease activity
KPZ59_02225	COG1294	oxidase, subunit
KPZ59_02226	COG4890	Cyd operon protein YbgT
KPZ59_02228	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KPZ59_02230	COG0552	protein localization to endoplasmic reticulum
KPZ59_02235	COG0516	GMP reductase activity
KPZ59_02235	COG0517	IMP dehydrogenase activity
KPZ59_02236	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KPZ59_02237	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KPZ59_02239	COG0583	DNA-binding transcription factor activity
KPZ59_02240	COG0024	Methionine aminopeptidase
KPZ59_02246	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KPZ59_02246	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KPZ59_02247	COG1105	Belongs to the carbohydrate kinase PfkB family
KPZ59_02248	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KPZ59_02248	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KPZ59_02248	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KPZ59_02251	COG5001	Diguanylate cyclase
KPZ59_02251	COG3300	MHYT domain
KPZ59_02254	COG2135	peptidase activity
KPZ59_02255	COG0659	secondary active sulfate transmembrane transporter activity
KPZ59_02258	COG1113	amino acid transport
KPZ59_02260	COG1522	sequence-specific DNA binding
KPZ59_02265	COG1011	Hydrolase
KPZ59_02266	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KPZ59_02268	COG2137	regulation of response to DNA damage stimulus
KPZ59_02270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPZ59_02277	COG0575	Belongs to the CDS family
KPZ59_02278	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KPZ59_02282	COG3852	Histidine kinase
KPZ59_02283	COG2204	response regulator
KPZ59_02294	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KPZ59_02295	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KPZ59_02299	COG0697	spore germination
KPZ59_02300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_02302	COG0303	'Molybdopterin
KPZ59_02303	COG0521	Mo-molybdopterin cofactor biosynthetic process
KPZ59_02303	COG0315	cyclic pyranopterin monophosphate synthase activity
KPZ59_02306	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KPZ59_02307	COG0243	molybdopterin cofactor binding
KPZ59_02309	COG0243	molybdopterin cofactor binding
KPZ59_02310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_02311	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_02311	COG2146	nitrite reductase [NAD(P)H] activity
KPZ59_02313	COG0745	RESPONSE REGULATOR receiver
KPZ59_02314	COG1116	anion transmembrane transporter activity
KPZ59_02314	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_02317	COG0511	ligase activity, forming carbon-carbon bonds
KPZ59_02320	COG2814	Major facilitator Superfamily
KPZ59_02325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_02338	COG0592	DNA-directed DNA polymerase activity
KPZ59_02380	COG1484	DNA-dependent DNA replication
KPZ59_02398	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_02412	COG0069	glutamate synthase activity
KPZ59_02416	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KPZ59_02418	COG1454	alcohol dehydrogenase
KPZ59_02419	COG0824	Thioesterase
KPZ59_02421	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KPZ59_02426	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KPZ59_02427	COG2030	dehydratase
KPZ59_02429	COG0183	Belongs to the thiolase family
KPZ59_02431	COG0583	DNA-binding transcription factor activity
KPZ59_02432	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KPZ59_02434	COG1522	sequence-specific DNA binding
KPZ59_02435	COG3135	benzoate transporter
KPZ59_02441	COG0589	response to stress
KPZ59_02442	COG0488	(ABC) transporter
KPZ59_02444	COG4773	Receptor
KPZ59_02450	COG0668	transmembrane transport
KPZ59_02458	COG0583	DNA-binding transcription factor activity
KPZ59_02459	COG2814	Major facilitator Superfamily
KPZ59_02460	COG2814	Major facilitator Superfamily
KPZ59_02461	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_02462	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPZ59_02463	COG3384	dioxygenase
KPZ59_02464	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_02466	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KPZ59_02467	COG4638	Rieske (2fe-2S)
KPZ59_02468	COG0583	DNA-binding transcription factor activity
KPZ59_02472	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KPZ59_02473	COG3971	2-oxopent-4-enoate hydratase activity
KPZ59_02475	COG2271	Major facilitator Superfamily
KPZ59_02476	COG1234	tRNA 3'-trailer cleavage
KPZ59_02484	COG1538	Outer membrane efflux protein
KPZ59_02486	COG2885	chlorophyll binding
KPZ59_02486	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KPZ59_02495	COG1605	Chorismate mutase
KPZ59_02499	COG0308	aminopeptidase N
KPZ59_02503	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KPZ59_02505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPZ59_02506	COG1454	alcohol dehydrogenase
KPZ59_02510	COG0531	amino acid
KPZ59_02511	COG4303	Ethanolamine ammonia lyase large subunit
KPZ59_02512	COG4302	ethanolamine ammonia-lyase activity
KPZ59_02513	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KPZ59_02513	COG0519	Catalyzes the synthesis of GMP from XMP
KPZ59_02514	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KPZ59_02519	COG0697	spore germination
KPZ59_02520	COG1923	regulation of RNA biosynthetic process
KPZ59_02522	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KPZ59_02523	COG0802	atpase or kinase
KPZ59_02527	COG1187	pseudouridine synthase activity
KPZ59_02530	COG0583	DNA-binding transcription factor activity
KPZ59_02533	COG2814	Major facilitator Superfamily
KPZ59_02534	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPZ59_02540	COG0729	surface antigen
KPZ59_02544	COG0174	glutamine synthetase
KPZ59_02545	COG0745	RESPONSE REGULATOR receiver
KPZ59_02546	COG2205	protein histidine kinase activity
KPZ59_02548	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KPZ59_02549	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KPZ59_02555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_02556	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPZ59_02557	COG1960	acyl-CoA dehydrogenase activity
KPZ59_02563	COG0583	DNA-binding transcription factor activity
KPZ59_02566	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_02568	COG3658	cytochrome
KPZ59_02569	COG1215	transferase activity, transferring glycosyl groups
KPZ59_02570	COG1649	PFAM Uncharacterised BCR, COG1649
KPZ59_02570	COG0726	polysaccharide deacetylase
KPZ59_02575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KPZ59_02576	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KPZ59_02578	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KPZ59_02583	COG0305	Participates in initiation and elongation during chromosome replication
KPZ59_02584	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KPZ59_02586	COG1305	Transglutaminase-like
KPZ59_02588	COG2308	Evidence 4 Homologs of previously reported genes of
KPZ59_02594	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KPZ59_02595	COG0138	bifunctional purine biosynthesis protein purh
KPZ59_02596	COG0151	Belongs to the GarS family
KPZ59_02597	COG1464	Belongs to the NlpA lipoprotein family
KPZ59_02598	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KPZ59_02599	COG2011	ABC-type metal ion transport system permease component
KPZ59_02600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPZ59_02602	COG1301	dicarboxylic acid transport
KPZ59_02607	COG2814	Major facilitator Superfamily
KPZ59_02610	COG1309	transcriptional regulator
KPZ59_02614	COG1794	racemase activity, acting on amino acids and derivatives
KPZ59_02615	COG0492	ferredoxin-NADP+ reductase activity
KPZ59_02615	COG3118	belongs to the thioredoxin family
KPZ59_02618	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KPZ59_02618	COG3008	intermembrane lipid transfer
KPZ59_02619	COG2995	paraquat-inducible protein a
KPZ59_02625	COG1051	belongs to the nudix hydrolase family
KPZ59_02626	COG0477	Major facilitator Superfamily
KPZ59_02636	COG2186	Transcriptional regulator
KPZ59_02638	COG0786	glutamate:sodium symporter activity
KPZ59_02639	COG3243	poly(R)-hydroxyalkanoic acid synthase
KPZ59_02645	COG3111	PFAM Bacterial OB fold (BOF) protein
KPZ59_02647	COG2226	methyltransferase
KPZ59_02662	COG3210	domain, Protein
KPZ59_02662	COG3210	domain, Protein
KPZ59_02663	COG2831	hemolysin activation secretion protein
KPZ59_02668	COG2815	serine threonine protein kinase
KPZ59_02668	COG0515	serine threonine protein kinase
KPZ59_02674	COG1610	YqeY-like protein
KPZ59_02675	COG4783	chaperone-mediated protein folding
KPZ59_02680	COG1286	toxin biosynthetic process
KPZ59_02686	COG0778	Nitroreductase
KPZ59_02688	COG0513	Belongs to the DEAD box helicase family
KPZ59_02692	COG2363	Small membrane protein
KPZ59_02698	COG4650	regulator
KPZ59_02699	COG1234	tRNA 3'-trailer cleavage
KPZ59_02700	COG1690	Belongs to the RtcB family
KPZ59_02704	COG2195	Cleaves the N-terminal amino acid of tripeptides
KPZ59_02706	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KPZ59_02708	COG2819	hydrolase of the alpha beta superfamily
KPZ59_02709	COG1960	acyl-CoA dehydrogenase activity
KPZ59_02710	COG1301	dicarboxylic acid transport
KPZ59_02711	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KPZ59_02712	COG3139	Protein of unknown function (DUF1315)
KPZ59_02713	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KPZ59_02714	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KPZ59_02716	COG0494	nUDIX hydrolase
KPZ59_02718	COG0642	Histidine kinase
KPZ59_02721	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KPZ59_02723	COG1720	tRNA m6t6A37 methyltransferase activity
KPZ59_02726	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_02727	COG0826	peptidase U32
KPZ59_02728	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPZ59_02730	COG4598	ABC transporter
KPZ59_02731	COG4160	amino acid transport
KPZ59_02732	COG4215	(ABC) transporter
KPZ59_02736	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_02744	COG1131	(ABC) transporter
KPZ59_02745	COG0842	Transport permease protein
KPZ59_02748	COG0772	Belongs to the SEDS family
KPZ59_02749	COG2951	lytic endotransglycosylase activity
KPZ59_02755	COG2207	Transcriptional regulator
KPZ59_02758	COG0052	Belongs to the universal ribosomal protein uS2 family
KPZ59_02759	COG0024	Methionine aminopeptidase
KPZ59_02761	COG2223	nitrite transmembrane transporter activity
KPZ59_02764	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPZ59_02765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KPZ59_02766	COG1960	acyl-CoA dehydrogenase activity
KPZ59_02769	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KPZ59_02770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KPZ59_02771	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KPZ59_02775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPZ59_02776	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KPZ59_02777	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KPZ59_02784	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KPZ59_02786	COG0174	glutamine synthetase
KPZ59_02789	COG0512	Glutamine amidotransferase of anthranilate synthase
KPZ59_02790	COG0308	aminopeptidase N
KPZ59_02794	COG2840	Smr protein MutS2
KPZ59_02796	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KPZ59_02798	COG0302	gtp cyclohydrolase
KPZ59_02805	COG3739	integral membrane protein
KPZ59_02808	COG1169	isochorismate synthase
KPZ59_02810	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KPZ59_02811	COG1132	(ABC) transporter
KPZ59_02812	COG1132	(ABC) transporter
KPZ59_02815	COG1535	isochorismatase
KPZ59_02815	COG3433	isochorismatase activity
KPZ59_02816	COG1021	2,3-dihydroxybenzoate-AMP ligase
KPZ59_02817	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KPZ59_02819	COG4774	siderophore transport
KPZ59_02820	COG4607	ABC-type enterochelin transport system periplasmic component
KPZ59_02821	COG4604	ABC transporter, ATP-binding protein
KPZ59_02822	COG4605	iron ion homeostasis
KPZ59_02823	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KPZ59_02825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KPZ59_02829	COG2964	Protein conserved in bacteria
KPZ59_02831	COG1741	Belongs to the pirin family
KPZ59_02840	COG2879	small protein
KPZ59_02841	COG1966	Carbon starvation protein
KPZ59_02846	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KPZ59_02850	COG2211	Major facilitator Superfamily
KPZ59_02851	COG1067	ATP-dependent peptidase activity
KPZ59_02852	COG0583	DNA-binding transcription factor activity
KPZ59_02857	COG1686	Belongs to the peptidase S11 family
KPZ59_02858	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KPZ59_02865	COG0616	signal peptide processing
KPZ59_02866	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KPZ59_02868	COG0573	inorganic phosphate transmembrane transporter activity
KPZ59_02869	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KPZ59_02870	COG1113	amino acid transport
KPZ59_02871	COG3961	Belongs to the TPP enzyme family
KPZ59_02872	COG1522	sequence-specific DNA binding
KPZ59_02874	COG0076	glutamate decarboxylase activity
KPZ59_02875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KPZ59_02877	COG1309	transcriptional regulator
KPZ59_02880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_02887	COG0352	thiamine-phosphate diphosphorylase activity
KPZ59_02892	COG1203	CRISPR-associated helicase, Cas3
KPZ59_02898	COG0612	Peptidase, M16
KPZ59_02900	COG1823	symporter activity
KPZ59_02901	COG0583	DNA-binding transcription factor activity
KPZ59_02902	COG0477	Major facilitator Superfamily
KPZ59_02906	COG1187	pseudouridine synthase activity
KPZ59_02909	COG1686	Belongs to the peptidase S11 family
KPZ59_02910	COG1252	NADH dehydrogenase
KPZ59_02912	COG0415	Belongs to the DNA photolyase family
KPZ59_02915	COG1215	transferase activity, transferring glycosyl groups
KPZ59_02921	COG2070	2-Nitropropane dioxygenase
KPZ59_02932	COG0556	nucleotide-excision repair
KPZ59_02936	COG0436	Aminotransferase
KPZ59_02941	COG4221	oxidoreductase activity
KPZ59_02943	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KPZ59_02944	COG1381	Involved in DNA repair and RecF pathway recombination
KPZ59_02946	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KPZ59_02949	COG0681	Belongs to the peptidase S26 family
KPZ59_02952	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPZ59_02956	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KPZ59_02957	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KPZ59_02958	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KPZ59_02960	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KPZ59_02961	COG4208	sulfate ABC transporter
KPZ59_02962	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KPZ59_02963	COG0583	DNA-binding transcription factor activity
KPZ59_02964	COG4625	pathogenesis
KPZ59_02967	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KPZ59_02970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KPZ59_02972	COG1051	belongs to the nudix hydrolase family
KPZ59_02972	COG1056	cytidyltransferase-related domain
KPZ59_02973	COG1024	Enoyl-CoA hydratase
KPZ59_02976	COG2814	Major facilitator Superfamily
KPZ59_02977	COG0047	phosphoribosylformylglycinamidine synthase activity
KPZ59_02977	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KPZ59_02981	COG1473	amidohydrolase
KPZ59_02982	COG0824	Thioesterase
KPZ59_02986	COG0823	Involved in the tonB-independent uptake of proteins
KPZ59_02990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KPZ59_02997	COG0628	permease
KPZ59_02999	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KPZ59_03000	COG0596	Alpha beta hydrolase
KPZ59_03001	COG0616	signal peptide processing
KPZ59_03001	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KPZ59_03003	COG0658	competence protein
KPZ59_03003	COG2333	competence protein COMEC
KPZ59_03004	COG1136	(ABC) transporter
KPZ59_03005	COG4591	ABC-type transport system involved in lipoprotein release permease component
KPZ59_03012	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_03016	COG0463	Glycosyl transferase, family 2
KPZ59_03022	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KPZ59_03023	COG1280	lysine exporter protein (LysE YggA)
KPZ59_03025	COG0019	diaminopimelate decarboxylase activity
KPZ59_03027	COG1113	amino acid transport
KPZ59_03030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KPZ59_03032	COG3339	Conserved Protein
KPZ59_03033	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KPZ59_03034	COG0243	molybdopterin cofactor binding
KPZ59_03035	COG1929	Belongs to the glycerate kinase type-1 family
KPZ59_03039	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KPZ59_03043	COG0741	lytic transglycosylase activity
KPZ59_03047	COG0584	glycerophosphoryl diester phosphodiesterase
KPZ59_03052	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KPZ59_03053	COG1597	lipid kinase activity
KPZ59_03056	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KPZ59_03057	COG0477	Major facilitator Superfamily
KPZ59_03067	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KPZ59_03068	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KPZ59_03073	COG0505	Belongs to the CarA family
KPZ59_03077	COG0589	response to stress
KPZ59_03080	COG2843	Capsule synthesis protein
KPZ59_03084	COG2321	neutral zinc metallopeptidase
KPZ59_03085	COG2354	Protein conserved in bacteria
KPZ59_03089	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPZ59_03092	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KPZ59_03093	COG1053	succinate dehydrogenase
KPZ59_03094	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KPZ59_03095	COG2009	succinate dehydrogenase
KPZ59_03102	COG2921	Belongs to the UPF0250 family
KPZ59_03103	COG0321	lipoyl(octanoyl) transferase activity
KPZ59_03106	COG0531	amino acid
KPZ59_03108	COG1733	regulation of RNA biosynthetic process
KPZ59_03109	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KPZ59_03110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KPZ59_03110	COG1648	precorrin-2 dehydrogenase activity
KPZ59_03113	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KPZ59_03119	COG0671	phosphoesterase, PA-phosphatase related
KPZ59_03120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_03122	COG1538	Outer membrane efflux protein
KPZ59_03123	COG0393	Putative heavy-metal-binding
KPZ59_03124	COG0393	Putative heavy-metal-binding
KPZ59_03126	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_03128	COG0525	valine-tRNA ligase activity
KPZ59_03132	COG0583	DNA-binding transcription factor activity
KPZ59_03133	COG0004	ammonium transporteR
KPZ59_03135	COG0642	Histidine kinase
KPZ59_03136	COG0745	RESPONSE REGULATOR receiver
KPZ59_03137	COG2194	sulfuric ester hydrolase activity
KPZ59_03141	COG1752	Esterase of the alpha-beta hydrolase superfamily
KPZ59_03144	COG2315	Protein conserved in bacteria
KPZ59_03145	COG0142	geranyltranstransferase activity
KPZ59_03146	COG2828	Protein conserved in bacteria
KPZ59_03147	COG1113	amino acid transport
KPZ59_03149	COG0582	viral genome integration into host DNA
KPZ59_03156	COG0305	Participates in initiation and elongation during chromosome replication
KPZ59_03166	COG0464	growth
KPZ59_03170	COG2207	Transcriptional regulator
KPZ59_03175	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_03177	COG0560	Phosphoserine phosphatase
KPZ59_03179	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KPZ59_03181	COG1530	ribonuclease E activity
KPZ59_03182	COG0424	maF-like protein
KPZ59_03183	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KPZ59_03184	COG1792	Involved in formation and maintenance of cell shape
KPZ59_03185	COG1077	Cell shape determining protein MreB Mrl
KPZ59_03186	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KPZ59_03188	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KPZ59_03193	COG3590	peptidase
KPZ59_03194	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KPZ59_03195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KPZ59_03196	COG1752	Esterase of the alpha-beta hydrolase superfamily
KPZ59_03197	COG1115	amino acid carrier protein
KPZ59_03201	COG2814	Major facilitator Superfamily
KPZ59_03202	COG1289	transmembrane transporter activity
KPZ59_03204	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KPZ59_03212	COG1376	ErfK ybiS ycfS ynhG family protein
KPZ59_03213	COG2832	Protein of unknown function (DUF454)
KPZ59_03215	COG5510	response to toxic substance
KPZ59_03219	COG0840	transmembrane signaling receptor activity
KPZ59_03227	COG3422	double-strand break repair
KPZ59_03228	COG2824	Alkylphosphonate utilization operon protein PhnA
KPZ59_03229	COG3189	MarR family transcriptional regulator
KPZ59_03231	COG0354	folic acid binding
KPZ59_03232	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_03234	COG0679	Auxin Efflux Carrier
KPZ59_03235	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_03236	COG4772	TonB-dependent receptor
KPZ59_03237	COG2094	Belongs to the DNA glycosylase MPG family
KPZ59_03243	COG1217	gtp-binding protein TYPA
KPZ59_03244	COG2233	PERMEase
KPZ59_03246	COG0833	amino acid
KPZ59_03247	COG1690	Belongs to the RtcB family
KPZ59_03249	COG2885	chlorophyll binding
KPZ59_03249	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KPZ59_03251	COG0183	Belongs to the thiolase family
KPZ59_03255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_03259	COG2207	Transcriptional regulator
KPZ59_03260	COG0183	Belongs to the thiolase family
KPZ59_03264	COG2153	protein acetylation
KPZ59_03266	COG1272	protein, Hemolysin III
KPZ59_03267	COG0477	Major facilitator Superfamily
KPZ59_03270	COG0450	alkyl hydroperoxide reductase
KPZ59_03274	COG0285	dihydrofolate synthase activity
KPZ59_03284	COG2096	Adenosyltransferase
KPZ59_03288	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KPZ59_03289	COG0745	RESPONSE REGULATOR receiver
KPZ59_03290	COG2205	protein histidine kinase activity
KPZ59_03292	COG1960	acyl-CoA dehydrogenase activity
KPZ59_03293	COG1960	acyl-CoA dehydrogenase activity
KPZ59_03303	COG1215	transferase activity, transferring glycosyl groups
KPZ59_03306	COG1091	dTDP-4-dehydrorhamnose reductase activity
KPZ59_03310	COG0726	polysaccharide deacetylase
KPZ59_03313	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KPZ59_03314	COG5002	protein histidine kinase activity
KPZ59_03320	COG1862	Preprotein translocase
KPZ59_03322	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KPZ59_03323	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KPZ59_03325	COG3781	membrane
KPZ59_03326	COG0613	PHP domain protein
KPZ59_03328	COG2350	Protein conserved in bacteria
KPZ59_03334	COG1607	acyl-coa hydrolase
KPZ59_03346	COG2199	diguanylate cyclase activity
KPZ59_03348	COG1408	metallophosphoesterase
KPZ59_03349	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KPZ59_03351	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KPZ59_03355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KPZ59_03356	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KPZ59_03357	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KPZ59_03359	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KPZ59_03361	COG2969	positive regulation of protein catabolic process
KPZ59_03365	COG1960	acyl-CoA dehydrogenase activity
KPZ59_03366	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KPZ59_03369	COG1309	transcriptional regulator
KPZ59_03370	COG1960	acyl-CoA dehydrogenase activity
KPZ59_03379	COG1183	phosphatidylcholine synthase activity
KPZ59_03380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KPZ59_03386	COG0741	lytic transglycosylase activity
KPZ59_03386	COG1196	nuclear chromosome segregation
KPZ59_03386	COG0739	heme binding
KPZ59_03388	COG1702	phosphate starvation-inducible protein PhoH
KPZ59_03395	COG1295	ribonuclease BN
KPZ59_03396	COG0697	spore germination
KPZ59_03397	COG2169	Transcriptional regulator
KPZ59_03398	COG0179	Fumarylacetoacetate (FAA) hydrolase
KPZ59_03407	COG0557	exoribonuclease II activity
KPZ59_03408	COG0339	signal peptide processing
KPZ59_03409	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KPZ59_03416	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KPZ59_03417	COG1960	acyl-CoA dehydrogenase activity
KPZ59_03448	COG0626	cystathionine gamma-synthase activity
KPZ59_03449	COG0433	COG0433 Predicted ATPase
KPZ59_03450	COG1017	nitric oxide dioxygenase activity
KPZ59_03450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_03451	COG1959	2 iron, 2 sulfur cluster binding
KPZ59_03454	COG1301	dicarboxylic acid transport
KPZ59_03455	COG1946	Acyl-CoA thioesterase
KPZ59_03459	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KPZ59_03460	COG1040	competence protein
KPZ59_03461	COG0494	nUDIX hydrolase
KPZ59_03463	COG0598	Magnesium transport protein CorA
KPZ59_03465	COG2854	intermembrane phospholipid transfer
KPZ59_03467	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KPZ59_03468	COG1127	ABC transporter
KPZ59_03470	COG0513	Belongs to the DEAD box helicase family
KPZ59_03475	COG0408	coproporphyrinogen oxidase activity
KPZ59_03478	COG1960	acyl-CoA dehydrogenase activity
KPZ59_03480	COG1983	PspC domain protein
KPZ59_03481	COG0517	IMP dehydrogenase activity
KPZ59_03487	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_03492	COG0833	amino acid
KPZ59_03494	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KPZ59_03495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KPZ59_03497	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_03505	COG0583	DNA-binding transcription factor activity
KPZ59_03509	COG1106	Psort location Cytoplasmic, score
KPZ59_03512	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_03515	COG0628	permease
KPZ59_03517	COG1289	transmembrane transporter activity
KPZ59_03518	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_03519	COG1289	transmembrane transporter activity
KPZ59_03522	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_03523	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KPZ59_03525	COG0277	FAD linked oxidase domain protein
KPZ59_03526	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KPZ59_03531	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KPZ59_03532	COG5380	lipid catabolic process
KPZ59_03536	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KPZ59_03546	COG0194	GDP metabolic process
KPZ59_03548	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KPZ59_03552	COG3307	-O-antigen
KPZ59_03555	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KPZ59_03556	COG1704	LemA family
KPZ59_03558	COG0493	'glutamate synthase
KPZ59_03559	COG0067	glutamate synthase
KPZ59_03559	COG0070	glutamate synthase
KPZ59_03559	COG0069	glutamate synthase activity
KPZ59_03569	COG2226	methyltransferase
KPZ59_03572	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KPZ59_03573	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KPZ59_03582	COG0833	amino acid
KPZ59_03595	COG0488	(ABC) transporter
KPZ59_03596	COG2873	o-acetylhomoserine
KPZ59_03597	COG4221	oxidoreductase activity
KPZ59_03598	COG0659	secondary active sulfate transmembrane transporter activity
KPZ59_03602	COG0427	acetyl-CoA hydrolase
KPZ59_03608	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KPZ59_03615	COG2329	Antibiotic biosynthesis monooxygenase
KPZ59_03618	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KPZ59_03635	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_03636	COG1733	regulation of RNA biosynthetic process
KPZ59_03642	COG1733	regulation of RNA biosynthetic process
KPZ59_03646	COG0667	Aldo Keto reductase
KPZ59_03650	COG0583	DNA-binding transcription factor activity
KPZ59_03651	COG2814	Major facilitator Superfamily
KPZ59_03658	COG1335	isochorismatase
KPZ59_03660	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_03661	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KPZ59_03663	COG1113	amino acid transport
KPZ59_03665	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KPZ59_03673	COG2814	Major facilitator Superfamily
KPZ59_03675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KPZ59_03675	COG0352	thiamine-phosphate diphosphorylase activity
KPZ59_03675	COG0351	phosphomethylpyrimidine kinase
KPZ59_03679	COG1309	transcriptional regulator
KPZ59_03680	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KPZ59_03683	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KPZ59_03685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KPZ59_03686	COG3162	membrane
KPZ59_03687	COG2205	protein histidine kinase activity
KPZ59_03687	COG0784	Response regulator, receiver
KPZ59_03687	COG2198	Histidine kinase
KPZ59_03692	COG1522	sequence-specific DNA binding
KPZ59_03693	COG1335	isochorismatase
KPZ59_03694	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPZ59_03696	COG0668	transmembrane transport
KPZ59_03697	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KPZ59_03698	COG1519	Transferase
KPZ59_03699	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_03705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KPZ59_03710	COG0426	domain, Protein
KPZ59_03710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_03711	COG4774	siderophore transport
KPZ59_03712	COG2119	membrane
KPZ59_03714	COG0508	dehydrogenase complex catalyzes the overall conversion of
KPZ59_03716	COG4942	peptidase
KPZ59_03719	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KPZ59_03721	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KPZ59_03725	COG0189	ligase activity
KPZ59_03730	COG0708	Exodeoxyribonuclease III
KPZ59_03731	COG1393	Belongs to the ArsC family
KPZ59_03734	COG3706	GGDEF domain
KPZ59_03741	COG2351	hydroxyisourate hydrolase activity
KPZ59_03742	COG2233	PERMEase
KPZ59_03744	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_03746	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KPZ59_03747	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_03749	COG3150	esterase
KPZ59_03760	COG1388	LysM domain
KPZ59_03760	COG5632	N-Acetylmuramoyl-L-alanine amidase
KPZ59_03760	COG3409	Peptidoglycan-binding domain 1 protein
KPZ59_03763	COG2918	glutathione biosynthetic process
KPZ59_03766	COG2733	membrane
KPZ59_03767	COG0436	Aminotransferase
KPZ59_03768	COG0534	Mate efflux family protein
KPZ59_03785	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KPZ59_03786	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KPZ59_03788	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KPZ59_03789	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KPZ59_03790	COG0546	phosphoglycolate phosphatase activity
KPZ59_03792	COG0010	Belongs to the arginase family
KPZ59_03798	COG2188	Transcriptional regulator
KPZ59_03800	COG0523	cobalamin synthesis protein
KPZ59_03802	COG1113	amino acid transport
KPZ59_03804	COG0625	glutathione transferase activity
KPZ59_03808	COG1683	Conserved Protein
KPZ59_03809	COG0534	Mate efflux family protein
KPZ59_03811	COG0385	Bile acid
KPZ59_03812	COG1335	isochorismatase
KPZ59_03813	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_03817	COG2116	formate transmembrane transporter activity
KPZ59_03818	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KPZ59_03819	COG2133	pyrroloquinoline quinone binding
KPZ59_03820	COG2983	Belongs to the UPF0260 family
KPZ59_03824	COG1194	a g-specific adenine glycosylase
KPZ59_03827	COG2818	Glycosylase
KPZ59_03828	COG1064	alcohol dehydrogenase
KPZ59_03829	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_03831	COG0583	DNA-binding transcription factor activity
KPZ59_03832	COG0656	L-ascorbic acid biosynthetic process
KPZ59_03833	COG2814	Major facilitator Superfamily
KPZ59_03840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_03843	COG2233	PERMEase
KPZ59_03844	COG0583	DNA-binding transcription factor activity
KPZ59_03851	COG0733	neurotransmitter:sodium symporter activity
KPZ59_p300012	COG1525	nuclease
KPZ59_p300024	COG1475	DNA binding
KPZ59_p300028	COG3853	Toxic anion resistance protein (TelA)
KPZ59_p300037	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_p300039	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_p300050	COG1002	Type II restriction enzyme, methylase subunits
KPZ59_p300051	COG1061	Type III restriction enzyme res subunit
KPZ59_p300058	COG0484	heat shock protein binding
KPZ59_p300079	COG0741	lytic transglycosylase activity
KPZ59_p300085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_p300101	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_p400001	COG1192	Involved in chromosome partitioning
KPZ59_p400003	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_p400011	COG0739	heme binding
KPZ59_p400061	COG0501	Belongs to the peptidase M48B family
KPZ59_p400074	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KPZ59_p400084	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KPZ59_p400092	COG3173	Aminoglycoside phosphotransferase
KPZ59_p400093	COG0488	(ABC) transporter
KPZ59_p400095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KPZ59_p400102	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KPZ59_p400135	COG2233	PERMEase
KPZ59_p400136	COG2351	hydroxyisourate hydrolase activity
KPZ59_p400143	COG0789	Transcriptional regulator
KPZ59_p400147	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KPZ59_p400148	COG0659	secondary active sulfate transmembrane transporter activity
KPZ59_p400160	COG1373	ATPase (AAA superfamily
KPZ59_p400167	COG1309	transcriptional regulator
KPZ59_p400172	COG0633	Ferredoxin
KPZ59_p400173	COG2207	Transcriptional regulator
KPZ59_p400206	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB