locus-tag class description DLD53_00175 ENOG4105DFP Integrase DLD53_00185 ENOG4105DUX Transporter DLD53_00190 ENOG4105C5F glutamine synthetase DLD53_00200 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DLD53_00235 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DLD53_00240 ENOG4107QNR UPF0135 protein DLD53_00245 ENOG4105C0H protease DLD53_00255 ENOG4105C6K Malic enzyme DLD53_00260 ENOG4105BZU Histidine kinase DLD53_00275 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DLD53_00280 ENOG4105SYT Methylenetetrahydrofolate reductase DLD53_00285 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) DLD53_00300 ENOG4107QPN acyl-Coa dehydrogenase DLD53_00305 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DLD53_00310 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DLD53_00320 ENOG4107RNU major facilitator superfamily MFS_1 DLD53_00330 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DLD53_00335 ENOG4105CE9 30S ribosomal protein S2 DLD53_00375 ENOG4105CVE Lytic murein transglycosylase DLD53_00380 ENOG4105CNI cell division protein FtsW DLD53_00395 ENOG4105E3A (ABC) transporter DLD53_00400 ENOG4105DA5 (ABC) transporter DLD53_00435 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DLD53_00445 ENOG4105ENT Efflux transporter rnd family, mfp subunit DLD53_00455 ENOG4105E89 ABC transporter DLD53_00460 ENOG4105DSP amino acid AbC transporter DLD53_00465 ENOG4106YG3 ABC transporter DLD53_00470 ENOG4108JEH abc transporter atp-binding protein DLD53_00480 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DLD53_00485 ENOG4105CFP Peptidase U32 DLD53_00490 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DLD53_00495 ENOG4105JAB phenazine biosynthesis protein, phzf family DLD53_00500 ENOG4105DP0 ferredoxin-NADP reductase DLD53_00505 ENOG4108R96 Methyltransferase, YaeB family DLD53_00515 ENOG4107QHF type ii secretion system protein e DLD53_00525 ENOG4105XJC Two component transcriptional regulator (Winged helix family DLD53_00530 ENOG4105DHQ Histidine kinase DLD53_00540 ENOG4105M6F mutator MutT protein DLD53_00550 ENOG4105BZ4 penicillin-binding protein DLD53_00555 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DLD53_00560 ENOG4105VUT cytoplasmic protein DLD53_00565 ENOG4107QYG anthranilate phosphoribosyltransferase DLD53_00575 ENOG4105CK2 sodium dicarboxylate symporter DLD53_00580 ENOG4105C1G acyl-Coa dehydrogenase DLD53_00585 ENOG4105NIV Esterase DLD53_00590 ENOG4105CQC Prephenate dehydratase DLD53_00595 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DLD53_00605 ENOG4105CIN aminoacyl-histidine dipeptidase DLD53_00610 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DLD53_00640 ENOG4105M08 Membrane DLD53_00645 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DLD53_00655 ENOG4105VEQ Cold shock protein DLD53_00660 ENOG4105C1J atp-dependent rna helicase DLD53_00670 ENOG41069NU Nitroreductase DLD53_00705 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DLD53_00720 ENOG4105C5I Dehydrogenase DLD53_00725 ENOG4105ERG peptidase m48, ste24p DLD53_00730 ENOG4105KTH gatB Yqey DLD53_00735 ENOG4105VCC 30S ribosomal protein S21 DLD53_00760 ENOG4105D9P serine threonine protein kinase DLD53_00785 ENOG4105EVZ LysR family transcriptional regulator DLD53_00790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DLD53_00795 ENOG4105C26 Dehydrogenase DLD53_00830 ENOG4105H4F exported protein DLD53_00870 ENOG4105D6U Sodium Glutamate Symporter DLD53_00880 ENOG4105JXH GntR family transcriptional regulator DLD53_00930 ENOG4105CSH Transporter DLD53_00955 ENOG4105CEB Aspartate aminotransferase DLD53_00970 ENOG4105F1S paraquat-inducible protein a DLD53_00975 ENOG4105DY2 Paraquat-inducible protein b DLD53_01015 ENOG4105CK2 sodium dicarboxylate symporter DLD53_01030 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DLD53_01035 ENOG4108UMI ABC transporter, permease DLD53_01040 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DLD53_01050 ENOG4105C12 Phosphoribosylglycinamide synthetase DLD53_01055 ENOG4105DC1 bifunctional purine biosynthesis protein purh DLD53_01060 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DLD53_01110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DLD53_01115 ENOG4105CDU Replicative dna helicase DLD53_01140 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DLD53_01145 ENOG4105CCU oxidase (Subunit III) DLD53_01150 ENOG4105BZ9 Cytochrome C oxidase, subunit I DLD53_01155 ENOG4105E2S oxidase) subunit II DLD53_01180 ENOG4107BJW polysaccharide deacetylase DLD53_01195 ENOG4105CND Glycosyl transferase, family 2 DLD53_01200 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD DLD53_01210 ENOG4105DEN Luciferase family DLD53_01230 ENOG4105CC0 LysR family Transcriptional regulator DLD53_01245 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DLD53_01250 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DLD53_01255 ENOG4105GVF (ABC) transporter DLD53_01270 ENOG4105C1G acyl-Coa dehydrogenase DLD53_01280 ENOG4108MEJ flavin reductase domain protein DLD53_01285 ENOG4105D06 uba thif-type nad fad binding protein DLD53_01305 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DLD53_01310 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DLD53_01320 ENOG4105C08 Histidine kinase DLD53_01325 ENOG4105EEX Two component transcriptional regulator (Winged helix family DLD53_01330 ENOG4105CFQ glutamine synthetase DLD53_01345 ENOG4107S74 Lysophospholipid transporter LplT DLD53_01350 ENOG4105CFU surface antigen DLD53_01370 ENOG4107QIJ Aconitate hydratase 2 DLD53_01380 ENOG4105EYW Ion transport protein DLD53_01385 ENOG4105F27 Major Facilitator DLD53_01400 ENOG4105DZ2 Transcriptional regulator DLD53_01435 ENOG4105K8N protein family UPF0079, ATPase DLD53_01440 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DLD53_01450 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DLD53_01455 ENOG4108TZV Membrane DLD53_01460 ENOG4108RCM Nitroreductase DLD53_01470 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) DLD53_01485 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DLD53_01490 ENOG4107FQ9 ethanolamine ammonia-lyase DLD53_01495 ENOG4105CPD ethanolamine ammonia-lyase DLD53_01500 ENOG4107R55 ethanolamine transporter DLD53_01510 ENOG4107RR1 TRANSCRIPTIONal DLD53_01520 ENOG4105C0A alcohol dehydrogenase DLD53_01525 ENOG4107QUV Domain protein DLD53_01535 ENOG4105F4I Transcriptional regulator DLD53_01555 ENOG4105CD8 aminopeptidase N DLD53_01565 ENOG4105EMU Dehydrogenase DLD53_01575 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) DLD53_01580 ENOG4105EW9 transcriptional regulator AsnC family DLD53_01595 ENOG4105R8C Transcriptional regulator DLD53_01605 ENOG4105CUY Mechanosensitive ion channel DLD53_01635 ENOG4105CNM Receptor DLD53_01655 ENOG4105C5H ABC transporter DLD53_01660 ENOG41081QV Universal stress protein DLD53_01675 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DLD53_01685 ENOG4105DKK Benzoate DLD53_01690 ENOG4105EW9 transcriptional regulator AsnC family DLD53_01695 ENOG4108NIW Leucine export protein LeuE DLD53_01700 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DLD53_01705 ENOG4105C5Q Transcriptional regulator DLD53_01715 ENOG4105CHU acetyl-coa acetyltransferase DLD53_01720 ENOG4105CHR reductase DLD53_01745 ENOG4107QMP dna polymerase iii subunits gamma and tau DLD53_01760 ENOG4105C0A alcohol dehydrogenase DLD53_01790 ENOG4105CBC glutamate synthase DLD53_02065 ENOG4105UPP uncharacterized protein ydcA DLD53_02150 ENOG4105DIJ Phosphoethanolamine transferase DLD53_02155 ENOG4105D8G Major Facilitator superfamily DLD53_02165 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DLD53_02170 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DLD53_02195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DLD53_02205 ENOG4107QZF nitrite reductase NADPH large subunit DLD53_02210 ENOG4108IFG nitrite reductase, (NAD(P)H) DLD53_02230 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DLD53_02245 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DLD53_02250 ENOG4105CVM Molybdenum cofactor synthesis domain protein DLD53_02260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DLD53_02265 ENOG4105T38 integral membrane protein DLD53_02285 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) DLD53_02290 ENOG4105CMR udp-glucose 4-epimerase DLD53_02355 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DLD53_02360 ENOG4105CUX Signal transduction histidine kinase DLD53_02380 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DLD53_02385 ENOG4105KNE Phosphatidate cytidylyltransferase DLD53_02395 ENOG4105DZP Membrane-associated zinc metalloprotease DLD53_02420 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DLD53_02435 ENOG4105Y3E Modulates RecA activity (By similarity) DLD53_02445 ENOG4105VEJ Heat shock protein DLD53_02450 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 DLD53_02475 ENOG4105F7P transcriptional regulator AsnC family DLD53_02485 ENOG4105C85 amino acid DLD53_02495 ENOG4105F9F transposase DLD53_02505 ENOG4105CHH sulfate transporter DLD53_02510 ENOG4108RAV Conserved protein DLD53_02515 ENOG4105D8V Glucose sorbosone dehydrogenase DLD53_02525 ENOG4105BZU Histidine kinase DLD53_02545 ENOG4105DM4 PTS System DLD53_02550 ENOG4105DE4 1-phosphofructokinase DLD53_02555 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DLD53_02580 ENOG4105CWM branched-chain amino acid transport system II carrier protein DLD53_02585 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DLD53_02590 ENOG4105CC0 LysR family Transcriptional regulator DLD53_02600 ENOG4105M2J Glutaredoxin DLD53_02605 ENOG4105C8Y Acetylornithine aminotransferase DLD53_02610 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DLD53_02635 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DLD53_02645 ENOG41068P6 UPF0319 protein DLD53_02665 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DLD53_02670 ENOG4105C4M (Ubiquinol oxidase) subunit I DLD53_02685 ENOG4105PV3 Inner membrane protein yqiJ DLD53_02700 ENOG4105E0K tonB-dependent siderophore receptor DLD53_02710 ENOG4105HDD phospholipase DLD53_02715 ENOG4105CZN Potassium uptake protein DLD53_02725 ENOG4105C7B Threonine dehydratase DLD53_02755 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DLD53_02760 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DLD53_02770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DLD53_02785 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DLD53_02830 ENOG4107VMU Membrane DLD53_02835 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DLD53_02845 ENOG4107QP7 CoA-transferase subunit A DLD53_02850 ENOG4107QNJ CoA-transferase subunit B DLD53_02855 ENOG4105CHU acetyl-coa acetyltransferase DLD53_02860 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase DLD53_02865 ENOG4105F2Z 3-oxoadipate enol-lactonase DLD53_02870 ENOG4105D2S major facilitator superfamily DLD53_02875 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DLD53_02880 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta DLD53_02885 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha DLD53_02890 ENOG4105FF2 Type I DHQase DLD53_02895 ENOG4106JPM 3-dehydroshikimate dehydratase DLD53_02900 ENOG4105TW1 Carbohydrate-selective porin OprB DLD53_02905 ENOG4105DZG Dehydrogenase DLD53_02915 ENOG4105MD1 YeeE YedE family protein DLD53_02930 ENOG4107HP6 Transcriptional regulator DLD53_02935 ENOG4108PTX LysR family Transcriptional regulator DLD53_02940 ENOG4105C1G acyl-Coa dehydrogenase DLD53_02965 ENOG4105DNH Major Facilitator DLD53_02975 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DLD53_02995 ENOG4105FUY alpha subunit DLD53_03005 ENOG4105CHR reductase DLD53_03025 ENOG4105F11 amine oxidase DLD53_03035 ENOG4105C26 Dehydrogenase DLD53_03045 ENOG4105F2Z 3-oxoadipate enol-lactonase DLD53_03050 ENOG4105CHU acetyl-coa acetyltransferase DLD53_03055 ENOG4107QNJ CoA-transferase subunit B DLD53_03060 ENOG4107QP7 CoA-transferase subunit A DLD53_03070 ENOG4105NN7 muconolactone delta-isomerase DLD53_03075 ENOG4105DTQ mandelate racemase muconate lactonizing DLD53_03080 ENOG4108KB2 LysR family Transcriptional regulator DLD53_03090 ENOG4107EJG GntR family transcriptional regulator DLD53_03110 ENOG4105CZJ Aldehyde dehydrogenase DLD53_03130 ENOG4105C1G acyl-Coa dehydrogenase DLD53_03135 ENOG4105CHR reductase DLD53_03140 ENOG4108JU7 Transcriptional regulator DLD53_03150 ENOG41062QD Membrane DLD53_03165 ENOG4107RGH Aldehyde dehydrogenase DLD53_03180 ENOG4105CH6 catalase DLD53_03205 ENOG4105K56 Transcriptional regulator DLD53_03210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DLD53_03220 ENOG4105NAE bifunctional deaminase-reductase domain protein DLD53_03250 ENOG4107Z3H Transcriptional regulator, TetR family DLD53_03260 ENOG4105CHJ isochorismatase hydrolase DLD53_03265 ENOG4105EJC lysr family transcriptional regulator DLD53_03270 ENOG4105D8V Glucose sorbosone dehydrogenase DLD53_03275 ENOG4105CKD glutathione-regulated potassium-efflux system protein DLD53_03285 ENOG4105CH2 amidohydrolase DLD53_03300 ENOG4105D5K Hemolysin activator protein DLD53_03305 ENOG4105CKT filamentous hemagglutinin DLD53_03335 ENOG4105FDP GntR family transcriptional regulator DLD53_03350 ENOG4106KR7 LysR family Transcriptional regulator DLD53_03375 ENOG4108JQ1 Dehydrogenase DLD53_03380 ENOG4105JSC dimethylmenaquinone methyltransferase DLD53_03405 ENOG4105F9F transposase DLD53_03425 ENOG4105CZJ Aldehyde dehydrogenase DLD53_03430 ENOG4105C01 Dihydroxy-acid dehydratase DLD53_03440 ENOG4105DDW LysR family Transcriptional regulator DLD53_03445 ENOG4105EXW epimerase dehydratase DLD53_03455 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DLD53_03460 ENOG4105CF7 AraC family transcriptional regulator DLD53_03475 ENOG4105DQ4 alcohol dehydrogenase DLD53_03485 ENOG4105EHG Permease protein DLD53_03490 ENOG4105E0A ABC, transporter DLD53_03510 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DLD53_03580 ENOG4105F9F transposase DLD53_03595 ENOG4108UAJ Transcriptional regulator DLD53_03635 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) DLD53_03690 ENOG4108BAS reductase DLD53_03705 ENOG4108R6W Transcriptional regulator, ARAC family DLD53_03710 ENOG4108821 RND type efflux pump DLD53_03715 ENOG4105E0F Histidine kinase DLD53_03720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DLD53_03725 ENOG4105C1P efflux transporter, rnd family, mfp subunit DLD53_03730 ENOG4105BZS acriflavin resistance protein DLD53_03735 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DLD53_03745 ENOG4105CT3 Monooxygenase DLD53_03765 ENOG4105CJP fad dependent oxidoreductase DLD53_03825 ENOG4107RZC phospholipase d DLD53_03845 ENOG4108IGT Dipeptidase DLD53_03880 ENOG4107T31 5'-nucleotidase DLD53_03890 ENOG4105WQI isochorismatase DLD53_03895 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DLD53_03910 ENOG4105E0C molybdate abc transporter DLD53_03915 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DLD53_03920 ENOG4105F4R Transcriptional regulator mode DLD53_03925 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit DLD53_03930 ENOG4108YS2 small subunit DLD53_03935 ENOG4105F57 Anthranilate dioxygenase reductase DLD53_03960 ENOG4105CHR reductase DLD53_03970 ENOG4105D2S major facilitator superfamily DLD53_03975 ENOG4105CF7 AraC family transcriptional regulator DLD53_03980 ENOG4105DTD Dehydrogenase DLD53_03985 ENOG4105CY2 Citrate transporter DLD53_03995 ENOG4108M0I Transcriptional regulator DLD53_04005 ENOG4107QNJ CoA-transferase subunit B DLD53_04010 ENOG4105CRW Short chain fatty acid transporter DLD53_04015 ENOG4105CHU acetyl-coa acetyltransferase DLD53_04025 ENOG4107YNJ LysR family Transcriptional regulator DLD53_04040 ENOG4108IJ0 Aspartate ammonia-lyase DLD53_04050 ENOG4105CSH Transporter DLD53_04070 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DLD53_04075 ENOG4106FTQ Taurine ABC transporter, periplasmic DLD53_04090 ENOG4105FDP GntR family transcriptional regulator DLD53_04100 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DLD53_04105 ENOG4105KVH Transcriptional regulator DLD53_04110 ENOG4105UEI Transcriptional Regulator AraC Family DLD53_04125 ENOG4108VCT Sulfite exporter TauE/SafE DLD53_04135 ENOG4107QPB Beta-lactamase domain protein DLD53_04145 ENOG4105FFC UPF0187 protein DLD53_04155 ENOG4105CHR reductase DLD53_04170 ENOG4105CPP Dehydrogenase, E1 component DLD53_04175 ENOG4107R0V Pyruvate dehydrogenase DLD53_04180 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DLD53_04195 ENOG4105BZU Histidine kinase DLD53_04205 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DLD53_04210 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DLD53_04255 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DLD53_04270 ENOG4105C28 cystathionine DLD53_04280 ENOG4105F2W methyltransferase DLD53_04310 ENOG4105K59 histidine triad (HIT) protein DLD53_04335 ENOG4107QWP ABC-2 type transporter DLD53_04340 ENOG4107QWP ABC-2 type transporter DLD53_04345 ENOG4105CJ1 ABC, transporter DLD53_04360 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DLD53_04365 ENOG4105CNM Receptor DLD53_04385 ENOG4107TSN permease DLD53_04390 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DLD53_04410 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DLD53_04415 ENOG4108YZT Adenosylcobinamide kinase DLD53_04470 ENOG4105DJU Siderophore biosynthesis protein DLD53_04475 ENOG4105DUU IucA IucC family protein DLD53_04495 ENOG4108Z66 YbaK ebsC protein DLD53_04510 ENOG4105C1G acyl-Coa dehydrogenase DLD53_04515 ENOG4105C1G acyl-Coa dehydrogenase DLD53_04520 ENOG4105EEF Alkane 1-monooxygenase DLD53_04525 ENOG4105E7U AraC family transcriptional regulator DLD53_04530 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DLD53_04535 ENOG4105K70 DNA-binding protein DLD53_04550 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DLD53_04560 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DLD53_04565 ENOG4108Z4V iron-sulfur cluster assembly DLD53_04580 ENOG4108ZIT Ferredoxin, 2FE-2S DLD53_04585 ENOG4105F8J Adenylate Guanylate cyclase DLD53_04595 ENOG4108JA2 transcriptioN-repair coupling factor DLD53_04615 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) DLD53_04620 ENOG4105K4T epimerase DLD53_04635 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase DLD53_04655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DLD53_04665 ENOG4105DGW oligopeptidase A DLD53_04705 ENOG4105SG9 biopolymer transport protein, ExbD DLD53_04715 ENOG4107QP3 malate synthase g DLD53_04720 ENOG4105D6Z AFG1 family ATPase DLD53_04730 ENOG4107RN6 Monooxygenase DLD53_04750 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DLD53_04755 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DLD53_04770 ENOG4108Z6B deaminase DLD53_04790 ENOG4108RTD type II secretion system protein K DLD53_04815 ENOG4105F8V Hydrolase, tatD family DLD53_04825 ENOG4107QRG dna polymerase iii DLD53_04835 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DLD53_04840 ENOG4105BZ1 (ABC) transporter DLD53_04855 ENOG4105FA0 parb-like partition protein DLD53_04860 ENOG4107QJE Chromosome Partitioning Protein DLD53_04870 ENOG4108S0S Nucleotidyl transferase DLD53_04875 ENOG4105EHM Aminoglycoside phosphotransferase DLD53_04880 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DLD53_04885 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DLD53_04890 ENOG4105D2N Aldolase DLD53_04910 ENOG4108UHJ MAF-like protein DLD53_04915 ENOG4105EZE Cupin 4 family protein DLD53_04925 ENOG41080HT Transcriptional regulator, arsr family DLD53_04935 ENOG4105XPP Protein of unknown function (DUF1275) DLD53_04940 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme DLD53_04945 ENOG4105BZ1 (ABC) transporter DLD53_04955 ENOG4108ZX5 transcriptional regulator DLD53_04965 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DLD53_04970 ENOG4105CK7 Sodium proline symporter DLD53_04975 ENOG4105EW9 transcriptional regulator AsnC family DLD53_04980 ENOG4105C26 Dehydrogenase DLD53_04985 ENOG4105YGK Pfam:UPF0157 DLD53_05000 ENOG4108T58 Mg2 transport protein CorA DLD53_05010 ENOG4108YYC ycei family DLD53_05020 ENOG4105CV1 Transketolase (EC 2.2.1.1) DLD53_05045 ENOG4108HWY Beta-lactamase DLD53_05065 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DLD53_05070 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DLD53_05090 ENOG4105X0I Fimbrial DLD53_05095 ENOG4105GQR Chaperone DLD53_05125 ENOG4108IPJ Membrane DLD53_05135 ENOG4105ETS cytosine purines uracil thiamine allantoin DLD53_05145 ENOG4105CC0 LysR family Transcriptional regulator DLD53_05165 ENOG41067SE Tetr family transcriptional regulator DLD53_05180 ENOG4105EW9 transcriptional regulator AsnC family DLD53_05190 ENOG4105CDA abc transporter atp-binding protein DLD53_05195 ENOG4105DRP amino acid AbC transporter DLD53_05200 ENOG4105EAD ABC transporter DLD53_05230 ENOG4105D01 (LipO)protein DLD53_05235 ENOG4105D01 (LipO)protein DLD53_05240 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DLD53_05245 ENOG4108UMI ABC transporter, permease DLD53_05250 ENOG4105C3G gtp-binding protein DLD53_05275 ENOG4108UMN azlc family DLD53_05280 ENOG4105ZED uncharacterized protein ygaH DLD53_05310 ENOG4105E7U AraC family transcriptional regulator DLD53_05315 ENOG4108V06 Glutathione peroxidase DLD53_05325 ENOG4105CHM Aminotransferase DLD53_05340 ENOG4105C0B DNA polymerase III (alpha subunit) DLD53_05365 ENOG4108JU3 Alkyl hydroperoxide reductase DLD53_05380 ENOG4108KB2 LysR family Transcriptional regulator DLD53_05385 ENOG4105D6J arsenicaL-resistance protein DLD53_05390 ENOG41082YX Transcriptional regulator, arsr family DLD53_05405 ENOG4105CPN adenine deaminase DLD53_05415 ENOG4105CBN LysR family transcriptional regulator DLD53_05425 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DLD53_05435 ENOG4105E2B Taurine dioxygenase DLD53_05440 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DLD53_05445 ENOG4108IY8 ABC, transporter DLD53_05450 ENOG4106FTQ Taurine ABC transporter, periplasmic DLD53_05460 ENOG4105C54 Major Facilitator superfamily DLD53_05485 ENOG4105C4M (Ubiquinol oxidase) subunit I DLD53_05490 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DLD53_05500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DLD53_05505 ENOG4108K70 Transcriptional regulator DLD53_05520 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DLD53_05525 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase DLD53_05540 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) DLD53_05545 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase DLD53_05555 ENOG4105DXI Major Facilitator superfamily DLD53_05575 ENOG41067MG lrgb family DLD53_05580 ENOG4105VAW lrga family DLD53_05585 ENOG4105CMU LysR family (Transcriptional regulator DLD53_05590 ENOG4108SHQ Glutathione S-transferase DLD53_05595 ENOG4105CYM Glutathione S-transferase DLD53_05600 ENOG4105CBN LysR family transcriptional regulator DLD53_05605 ENOG4105CHR reductase DLD53_05615 ENOG4105D7W serine acetyltransferase DLD53_05620 ENOG4105ESN nucleotide-binding protein DLD53_05625 ENOG4105C9B Cysteine desulfurase DLD53_05640 ENOG4105EXG Transcriptional regulator DLD53_05650 ENOG4105CT1 (ABC) transporter DLD53_05655 ENOG4107RP9 extracellular solute-binding protein, family 3 DLD53_05660 ENOG4105CDA abc transporter atp-binding protein DLD53_05665 ENOG4108HW4 amino acid AbC transporter DLD53_05670 ENOG4105EAD ABC transporter DLD53_05685 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DLD53_05690 ENOG4105BZU Histidine kinase DLD53_05700 ENOG4105EW9 transcriptional regulator AsnC family DLD53_05710 ENOG4105KT5 UmuD protein DLD53_05730 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DLD53_05775 ENOG4105HEI LysR family (Transcriptional regulator DLD53_05795 ENOG4105CEY Amp-dependent synthetase and ligase DLD53_05800 ENOG4105R8C Transcriptional regulator DLD53_05805 ENOG4105C1G acyl-Coa dehydrogenase DLD53_05810 ENOG4107QX3 carboxylase DLD53_05815 ENOG4105E39 Enoyl-CoA hydratase DLD53_05830 ENOG4105CC0 LysR family Transcriptional regulator DLD53_05845 ENOG4105CSU acyl-Coa dehydrogenase DLD53_05855 ENOG4105EQ0 Major Facilitator superfamily DLD53_05865 ENOG4107QNJ CoA-transferase subunit B DLD53_05870 ENOG4107QP7 CoA-transferase subunit A DLD53_05875 ENOG4107RGD Major Facilitator superfamily DLD53_05880 ENOG4105C1G acyl-Coa dehydrogenase DLD53_05890 ENOG4105CHR reductase DLD53_05895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DLD53_05900 ENOG4105CHU acetyl-coa acetyltransferase DLD53_05910 ENOG4105EQ0 Major Facilitator superfamily DLD53_05915 ENOG4105EA8 2-Nitropropane dioxygenase DLD53_05920 ENOG4108UKI Enoyl-CoA hydratase DLD53_05935 ENOG4105C1G acyl-Coa dehydrogenase DLD53_05940 ENOG4107RGD Major Facilitator superfamily DLD53_05945 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DLD53_05950 ENOG4107STF Involved in phosphonate degradation (By similarity) DLD53_05960 ENOG4107RCV ABC transporter, permease DLD53_05965 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DLD53_05970 ENOG4105C4Y ABC transporter DLD53_05980 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase DLD53_05985 ENOG4107HP6 Transcriptional regulator DLD53_05995 ENOG4105HEI LysR family (Transcriptional regulator DLD53_06000 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DLD53_06005 ENOG4105C26 Dehydrogenase DLD53_06015 ENOG4105ETS cytosine purines uracil thiamine allantoin DLD53_06025 ENOG4105C26 Dehydrogenase DLD53_06030 ENOG4108M8W Monooxygenase DLD53_06035 ENOG4105MXW flavin reductase domain protein, FMN-binding DLD53_06040 ENOG4108MXF Alpha Beta Hydrolase DLD53_06060 ENOG4105CPW cytochrome b561 DLD53_06065 ENOG4107VGR Catalase DLD53_06100 ENOG4105F9F transposase DLD53_06115 ENOG4107YAU phenylacetic acid degradation protein DLD53_06125 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein DLD53_06130 ENOG4105DZS Phenylacetate-CoA ligase DLD53_06135 ENOG4105CHU acetyl-coa acetyltransferase DLD53_06140 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DLD53_06145 ENOG4108UKI Enoyl-CoA hydratase DLD53_06150 ENOG4105E39 Enoyl-CoA hydratase DLD53_06155 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DLD53_06160 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit DLD53_06165 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit DLD53_06170 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit DLD53_06175 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit DLD53_06180 ENOG4105DXM phenylacetic acid degradation protein DLD53_06185 ENOG4105EJQ L-serine dehydratase DLD53_06190 ENOG4107QTZ amino acid DLD53_06195 ENOG4105CZJ Aldehyde dehydrogenase DLD53_06220 ENOG4105MWK D-amino acid dehydrogenase, small subunit DLD53_06240 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DLD53_06260 ENOG4108Z4X TRANSCRIPTIONal DLD53_06270 ENOG4105WPN DNA integration recombination invertion protein DLD53_06275 ENOG4105F9F transposase DLD53_06290 ENOG4105DJ2 Major Facilitator Superfamily DLD53_06295 ENOG4107Y2X deaminase DLD53_06305 ENOG4105EMY transcriptional regulator DLD53_06335 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DLD53_06345 ENOG4105UYK outer membrane protein a DLD53_06375 ENOG4105I1F Resistance protein DLD53_06480 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) DLD53_06500 ENOG4105D2S major facilitator superfamily DLD53_06510 ENOG4105D1S lipid A biosynthesis DLD53_06515 ENOG4105BZU Histidine kinase DLD53_06520 ENOG4107AQZ Membrane DLD53_06540 ENOG4108Z4U Ferredoxin DLD53_06580 ENOG4105DFG type I secretion outer membrane protein DLD53_06585 ENOG4108IUZ ABC transporter DLD53_06590 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA DLD53_06600 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase DLD53_06605 ENOG4105C2X Arabinose 5-phosphate isomerase DLD53_06640 ENOG4107YPT transcriptional regulator DLD53_06675 ENOG4105II7 pyrroline-5-carboxylate reductase DLD53_06685 ENOG4105VEQ Cold shock protein DLD53_06690 ENOG410829K Lysine exporter protein (Lyse ygga) DLD53_06725 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DLD53_06795 ENOG4105EUV Phenol 2-monooxygenase DLD53_06815 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein DLD53_06825 ENOG4108KB2 LysR family Transcriptional regulator DLD53_06830 ENOG4105FUY alpha subunit DLD53_06835 ENOG4108UKV benzoate 1,2-dioxygenase DLD53_06840 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein DLD53_06845 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase DLD53_06850 ENOG4105DKK Benzoate DLD53_06860 ENOG4105EUZ Beta-lactamase domain protein DLD53_06865 ENOG4105D2S major facilitator superfamily DLD53_06880 ENOG4105CQ7 ATP-dependent helicase DLD53_06885 ENOG4105D3R alkyl hydroperoxide reductase DLD53_06895 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DLD53_06905 ENOG4108JU3 Alkyl hydroperoxide reductase DLD53_06915 ENOG4108K3A Glutathione S-transferase DLD53_06925 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DLD53_06930 ENOG4108TGY Glutathione S-transferase DLD53_06940 ENOG4108ZG0 Ompa motb domain protein DLD53_06945 ENOG4105CD3 dihydroorotase DLD53_06975 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DLD53_06990 ENOG4108UKZ OsmC family DLD53_06995 ENOG4107RYR Transcriptional regulator, Crp Fnr family DLD53_07000 ENOG4105CPC Aldo Keto reductase DLD53_07010 ENOG4105F9F transposase DLD53_07020 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DLD53_07030 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DLD53_07040 ENOG4105CFH Aspartokinase DLD53_07050 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DLD53_07060 ENOG4105CPW cytochrome b561 DLD53_07065 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DLD53_07070 ENOG4105C7N Xanthine uracil vitamin C permease DLD53_07080 ENOG4105F95 Monooxygenase DLD53_07125 ENOG4105C85 amino acid DLD53_07145 ENOG4105C26 Dehydrogenase DLD53_07165 ENOG4105CUB amino acid DLD53_07175 ENOG4105C85 amino acid DLD53_07220 ENOG4105CNA YD repeat protein DLD53_07240 ENOG4105D01 (LipO)protein DLD53_07250 ENOG4105F9F transposase DLD53_07270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DLD53_07290 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) DLD53_07310 ENOG4108JQ5 ABC transporter DLD53_07315 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component DLD53_07320 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component DLD53_07330 ENOG4105E9H Lytic Murein transglycosylase DLD53_07330 ENOG4105E9H Lytic Murein transglycosylase DLD53_07335 ENOG4107RZZ dna polymerase iii epsilon subunit DLD53_07345 ENOG4105E09 nadh pyrophosphatase DLD53_07355 ENOG4105W4M Transport-associated protein DLD53_07365 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DLD53_07375 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DLD53_07380 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DLD53_07400 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DLD53_07405 ENOG4105D0A hydroxylase DLD53_07410 ENOG4107RAQ aminopeptidase DLD53_07445 ENOG4105DIJ Phosphoethanolamine transferase DLD53_07805 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DLD53_07830 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DLD53_07840 ENOG4105D82 Glutamate dehydrogenase DLD53_07845 ENOG4108R3D Electron transport complex DLD53_07850 ENOG4105CSM endonuclease III DLD53_07875 ENOG4105CJN penicillin-binding protein DLD53_07880 ENOG4106H78 methyltransferase DLD53_07895 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DLD53_07905 ENOG4105CQM Urea amidohydrolase subunit alpha DLD53_07935 ENOG4107RET Isocitrate lyase DLD53_07945 ENOG4105C37 (CBS) domain DLD53_07955 ENOG4105D4T Citrate transporter DLD53_07970 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DLD53_07985 ENOG4108MRJ DLD53_08010 ENOG4105VCQ rubredoxin DLD53_08015 ENOG4107QZF nitrite reductase NADPH large subunit DLD53_08025 ENOG4105C5Q Transcriptional regulator DLD53_08045 ENOG4107U91 Rhomboid family DLD53_08050 ENOG4105CV6 ABC transporter, permease DLD53_08055 ENOG4108I0Y (ABC) transporter DLD53_08060 ENOG4108UJV acyl-CoA thioesterase i DLD53_08080 ENOG4107RNH Outer membrane receptor FepA DLD53_08095 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) DLD53_08100 ENOG4105E6M Sulphatase-modifying factor protein DLD53_08120 ENOG4105CJ3 phosphate transporter DLD53_08125 ENOG4105C3R Methionine synthase DLD53_08140 ENOG4105CSP Major Facilitator Superfamily DLD53_08150 ENOG4108PZW LysR family Transcriptional regulator DLD53_08165 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DLD53_08170 ENOG4105EU0 Major facilitator Superfamily DLD53_08175 ENOG4108R6W Transcriptional regulator, ARAC family DLD53_08180 ENOG4105CSV Glutaminase DLD53_08185 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DLD53_08190 ENOG4105CSH Transporter DLD53_08200 ENOG4105C7K acetolactate synthase DLD53_08215 ENOG4105CHR reductase DLD53_08220 ENOG4108MXF Alpha Beta Hydrolase DLD53_08230 ENOG4105DJB Major Facilitator Superfamily DLD53_08235 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase DLD53_08245 ENOG4105CHR reductase DLD53_08265 ENOG41069M3 Transcriptional regulator DLD53_08280 ENOG4106YT9 Enoyl-CoA hydratase DLD53_08290 ENOG4105CND Glycosyl transferase, family 2 DLD53_08295 ENOG4107BJW polysaccharide deacetylase DLD53_08305 ENOG4108VWS Yaeq family DLD53_08315 ENOG4105CKI cobalamin synthesis protein DLD53_08335 ENOG4105C94 Transporter DLD53_08340 ENOG4105C94 Transporter DLD53_08345 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DLD53_08370 ENOG4107QK5 Homocysteine s-methyltransferase DLD53_08375 ENOG4105D5Q Arginine ornithine antiporter DLD53_08400 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DLD53_08405 ENOG4105C54 Major Facilitator superfamily DLD53_08470 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DLD53_08475 ENOG4105C0R drug resistance transporter emrb qaca subfamily DLD53_08480 ENOG4105CW7 secretion protein, HlyD family DLD53_08485 ENOG4108VUY thioesterase Superfamily protein DLD53_08490 ENOG4105D52 delta-aminolevulinic acid dehydratase DLD53_08495 ENOG4105MWK D-amino acid dehydrogenase, small subunit DLD53_08500 ENOG4105ECP epimerase DLD53_08520 ENOG4107RH8 nuclease SbcCD subunit D DLD53_08525 ENOG4105EYH Exonuclease DLD53_08530 ENOG4105DFA alanine racemase domain protein DLD53_08535 ENOG4105CZX twitching motility protein DLD53_08540 ENOG4105CZX twitching motility protein DLD53_08545 ENOG41090R7 Ferric uptake DLD53_08575 ENOG4105E7A Glutamine amidotransferase DLD53_08590 ENOG4107QKV phosphomannomutase DLD53_08600 ENOG4105C4R Atp-dependent dna helicase DLD53_08605 ENOG4108ZG0 Ompa motb domain protein DLD53_08610 ENOG4106HNH Acyl-transferase DLD53_08625 ENOG4107QMS site-determining protein DLD53_08650 ENOG4105CNU cell division protein FtsK DLD53_08655 ENOG4105C3M thioredoxin reductase DLD53_08660 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DLD53_08670 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DLD53_08715 ENOG4108YXA Membrane DLD53_08720 ENOG4105EUB pirin domain protein DLD53_08730 ENOG4105C4K Nad synthetase DLD53_08745 ENOG4105E3J oxidoreductase DLD53_08750 ENOG4105C26 Dehydrogenase DLD53_08755 ENOG4105DVW rieske (2Fe-2S) DLD53_08765 ENOG4105C94 Transporter DLD53_08770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DLD53_08775 ENOG4105EJC lysr family transcriptional regulator DLD53_08795 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DLD53_08815 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DLD53_08820 ENOG4105C34 Pseudouridine synthase DLD53_08825 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DLD53_08830 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DLD53_08845 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) DLD53_08875 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DLD53_08905 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DLD53_08915 ENOG4105DWF phosphomethylpyrimidine kinase DLD53_08920 ENOG4109066 lysm domain bon superfamily protein DLD53_08930 ENOG4105CHR reductase DLD53_08935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DLD53_08945 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein DLD53_08950 ENOG4108BPE -transporting atpase DLD53_08955 ENOG4107RTD sua5 ycio yrdc ywlc family protein DLD53_08960 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DLD53_08965 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DLD53_08970 ENOG4105FE9 pseudouridine synthase DLD53_08980 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DLD53_08985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DLD53_08995 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DLD53_09000 ENOG4108K4C ec 3.1.3.12 DLD53_09005 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DLD53_09010 ENOG4106UW1 Major Facilitator superfamily DLD53_09030 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DLD53_09040 ENOG4105HF0 Membrane DLD53_09055 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DLD53_09065 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) DLD53_09125 ENOG4105D1F ATP-binding protein DLD53_09135 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DLD53_09165 ENOG4105K6H D-cysteine desulfhydrase DLD53_09170 ENOG4105CBX hi0933 family DLD53_09195 ENOG4105DP0 ferredoxin-NADP reductase DLD53_09200 ENOG4105DUM transcriptional regulator, lysR family DLD53_09220 ENOG4105C8S subunit m DLD53_09225 ENOG4105D65 subunit l DLD53_09235 ENOG4107UFS subunit j DLD53_09250 ENOG4108IEH NADH dehydrogenase subunit g DLD53_09255 ENOG4107QIZ NADH dehydrogenase DLD53_09260 ENOG4105GKE subunit e DLD53_09280 ENOG4105BZU Histidine kinase DLD53_09290 ENOG4105E0F Histidine kinase DLD53_09295 ENOG4107EXC regulatoR DLD53_09305 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DLD53_09315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DLD53_09330 ENOG4105F9F transposase DLD53_09405 ENOG4105F9F transposase DLD53_09420 ENOG4105DZG Dehydrogenase DLD53_09440 ENOG4105JAB phenazine biosynthesis protein, phzf family DLD53_09460 ENOG4105F9F transposase DLD53_09480 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) DLD53_09485 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DLD53_09495 ENOG4105ETT transcriptional Regulator, LysR family DLD53_09515 ENOG4105CH2 amidohydrolase DLD53_09525 ENOG4106P55 Transcriptional regulator DLD53_09545 ENOG4106P55 Transcriptional regulator DLD53_09550 ENOG4107EFR Flavocytochrome c DLD53_09560 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DLD53_09565 ENOG4107RGD Major Facilitator superfamily DLD53_09575 ENOG4105ETT transcriptional Regulator, LysR family DLD53_09610 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DLD53_09615 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DLD53_09620 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DLD53_09635 ENOG4105VR0 copper resistance DLD53_09640 ENOG4105E3B Multicopper oxidase DLD53_09650 ENOG4108HCJ Hydrolase DLD53_09655 ENOG4105DJV ribulose-phosphate 3-epimerase DLD53_09680 ENOG41072GX Peptidase M22 Glycoprotease DLD53_09685 ENOG4108Z0R Transferase DLD53_09730 ENOG4105CRQ synthase (Component I) DLD53_09740 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DLD53_09745 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DLD53_09750 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DLD53_09820 ENOG4105K56 Transcriptional regulator DLD53_09825 ENOG4108ZHJ Organic hydroperoxide resistance protein DLD53_09830 ENOG4107QHF type ii secretion system protein e DLD53_09850 ENOG4105C2M dna polymerase I DLD53_09855 ENOG4108VIA integral membrane protein DLD53_09860 ENOG4105II7 pyrroline-5-carboxylate reductase DLD53_09865 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DLD53_09875 ENOG4105C9X ppx gppa phosphatase DLD53_09885 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DLD53_09905 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DLD53_09930 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DLD53_09945 ENOG4105W39 Membrane DLD53_09950 ENOG4105CYM Glutathione S-transferase DLD53_09970 ENOG4105CEY Amp-dependent synthetase and ligase DLD53_09975 ENOG4105N42 UPF0307 protein DLD53_09980 ENOG41080Z8 PHOSPHOCARRIER protein DLD53_10000 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DLD53_10005 ENOG4105DJ0 Poly(A) Polymerase DLD53_10010 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein DLD53_10015 ENOG4105DXN mazG family DLD53_10025 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DLD53_10040 ENOG4105C6T cysteine synthase DLD53_10045 ENOG4105BZU Histidine kinase DLD53_10050 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase DLD53_10055 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DLD53_10060 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DLD53_10075 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DLD53_10080 ENOG4105W8H transhydrogenase (subunit alpha DLD53_10085 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DLD53_10090 ENOG4106UX7 integral membrane protein DLD53_10105 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DLD53_10115 ENOG4107RSM transcriptional regulator DLD53_10125 ENOG4105CUZ uba thif-type nad fad binding protein DLD53_10135 ENOG4107QM5 aconitate hydratase DLD53_10140 ENOG4105F8V Hydrolase, tatD family DLD53_10155 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DLD53_10185 ENOG4105BZU Histidine kinase DLD53_10195 ENOG4108ZP8 Acetolactate synthase small subunit DLD53_10200 ENOG4105C7K acetolactate synthase DLD53_10225 ENOG4105DJY efflux transporter, rnd family, mfp subunit DLD53_10230 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DLD53_10235 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DLD53_10240 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DLD53_10250 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DLD53_10255 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DLD53_10265 ENOG4105VW4 glutaredoxin 3 DLD53_10285 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DLD53_10290 ENOG4105C2D reductase DLD53_10300 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DLD53_10330 ENOG4105C84 Histidine ammonia-lyase DLD53_10345 ENOG4105CEY Amp-dependent synthetase and ligase DLD53_10360 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DLD53_10380 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DLD53_10400 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) DLD53_10420 ENOG4105WVQ Fe-S assembly protein IscX DLD53_10435 ENOG4105CN1 protease DLD53_10450 ENOG4106HB6 Alpha beta hydrolase DLD53_10460 ENOG4105C26 Dehydrogenase DLD53_10465 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DLD53_10470 ENOG4105C6Z Gluconate DLD53_10475 ENOG4108UHU Aldolase DLD53_10480 ENOG4105C01 Dihydroxy-acid dehydratase DLD53_10485 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DLD53_10490 ENOG4108DNC Involved in acetate metabolism (By similarity) DLD53_10495 ENOG4107GFK fumarate DLD53_10515 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DLD53_10525 ENOG4108ESX Receptor DLD53_10535 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DLD53_10545 ENOG4105DWV Homoserine O-trans-acetylase DLD53_10645 ENOG4105CIY formyltetrahydrofolate deformylase DLD53_10655 ENOG4107RGH Aldehyde dehydrogenase DLD53_10660 ENOG4105KDC 50s ribosomal protein l28 DLD53_10665 ENOG4105W0E 50S ribosomal protein L33 DLD53_10670 ENOG4105CKD glutathione-regulated potassium-efflux system protein DLD53_10690 ENOG4105VFU Rna-binding protein DLD53_10695 ENOG4105C4R Atp-dependent dna helicase DLD53_10710 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DLD53_10720 ENOG4105KVH Transcriptional regulator DLD53_10730 ENOG41069P5 Protein slyX homolog DLD53_10735 ENOG4105C5H ABC transporter DLD53_10740 ENOG4105N14 lysine exporter protein LysE YggA DLD53_10745 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase DLD53_10755 ENOG4105CK2 sodium dicarboxylate symporter DLD53_10810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DLD53_10835 ENOG4105DUM transcriptional regulator, lysR family DLD53_10860 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase DLD53_10875 ENOG4108W5M transcriptional regulator DLD53_10890 ENOG4105D29 Helix-turn-helix type 11 domain protein DLD53_10895 ENOG4107XGZ Hydrolase DLD53_10900 ENOG4105EI2 Pseudouridine synthase DLD53_10910 ENOG4105C03 ribonuclease DLD53_10930 ENOG4105CBN LysR family transcriptional regulator DLD53_10935 ENOG4105EMU Dehydrogenase DLD53_10940 ENOG4105CSA Coproporphyrinogen iii oxidase DLD53_10950 ENOG4107QI1 Mate efflux family protein DLD53_10960 ENOG4107T8P acyl-Coa dehydrogenase DLD53_11005 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DLD53_11010 ENOG4105C5X domain protein DLD53_11025 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DLD53_11035 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase DLD53_11040 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DLD53_11045 ENOG4108JU5 Magnesium and cobalt efflux protein DLD53_11050 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DLD53_11055 ENOG4108Z7R Chaperone CsaA DLD53_11065 ENOG4108VAU general secretion pathway protein G DLD53_11070 ENOG4105D7Q type ii secretion system DLD53_11075 ENOG4105C25 Primosomal protein n' DLD53_11080 ENOG4105CKD glutathione-regulated potassium-efflux system protein DLD53_11085 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DLD53_11095 ENOG4105DVC DnaJ domain protein DLD53_11100 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) DLD53_11105 ENOG4107QUT magnesium and cobalt transport protein CorA DLD53_11125 ENOG4107QYX exodeoxyribonuclease v alpha DLD53_11130 ENOG4107QKA exodeoxyribonuclease V beta DLD53_11135 ENOG4105DSY exodeoxyribonuclease V, gamma DLD53_11145 ENOG4105CSR polyphosphate kinase 2 DLD53_11155 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DLD53_11170 ENOG41061H0 Monooxygenase DLD53_11175 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DLD53_11190 ENOG4105D65 subunit l DLD53_11195 ENOG4108ZE9 Monovalent cation H antiporter subunit C DLD53_11200 ENOG4107R4Z monovalent cation h antiporter subunit d DLD53_11205 ENOG4105SC1 monovalent cation H antiporter subunit E DLD53_11210 ENOG4105W4C monovalent cation H antiporter subunit F DLD53_11215 ENOG4105KJM monovalent cation h antiporter subunit g DLD53_11230 ENOG4105CHV Transcription elongation factor NusA DLD53_11255 ENOG4107EJC Preprotein translocase subunit SecG DLD53_11265 ENOG4107QHF type ii secretion system protein e DLD53_11280 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DLD53_11290 ENOG4105C2N RNA methyltransferase TrmH family group 3 DLD53_11305 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DLD53_11315 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DLD53_11345 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DLD53_11350 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DLD53_11375 ENOG4105F9F transposase DLD53_11420 ENOG4107ZXU DSBA oxidoreductase DLD53_11435 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DLD53_11450 ENOG4105D3Y Na H antiporter DLD53_11455 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DLD53_11505 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DLD53_11510 ENOG4105PM1 preprotein translocase subunit SecE DLD53_11550 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DLD53_11555 ENOG4105TV9 FHA Domain-Containing protein DLD53_11560 ENOG4105GVR general secretion pathway protein D DLD53_11575 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS DLD53_11600 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DLD53_11605 ENOG4108NEV two component transcriptional regulator, LytTR family DLD53_11610 ENOG4108HRK Histidine kinase DLD53_11625 ENOG4108UTW Plays a role in the regulation of phosphate uptake DLD53_11630 ENOG4105DFG type I secretion outer membrane protein DLD53_11635 ENOG4108RNG Permease of the drug metabolite transporter DLD53_11660 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DLD53_11665 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DLD53_11670 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DLD53_11675 ENOG4105CNI cell division protein FtsW DLD53_11690 ENOG4105CE1 Ferrous iron transport protein b DLD53_11700 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DLD53_11705 ENOG4105T95 Thiol disulfide interChange protein DLD53_11710 ENOG4105D6E homoserine dehydrogenase DLD53_11720 ENOG41061WM D-Alanyl-D-Alanine DLD53_11730 ENOG4107TUY Histidine kinase DLD53_11735 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DLD53_11740 ENOG4105CN1 protease DLD53_11745 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DLD53_11750 ENOG4108K5H permease YjgP YjgQ family protein DLD53_11790 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DLD53_11800 ENOG4105BZU Histidine kinase DLD53_11815 ENOG4105C0P Mg chelatase subunit ChlI DLD53_11825 ENOG4108R0M Aminoglycoside DLD53_11870 ENOG4105CHH sulfate transporter DLD53_11905 ENOG4105C0P Mg chelatase subunit ChlI DLD53_11910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DLD53_11920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DLD53_11930 ENOG4105EPF Outer membrane porin DLD53_11935 ENOG4105F0N pyrophosphate phospho-hydrolase DLD53_11950 ENOG4105CEY Amp-dependent synthetase and ligase DLD53_11955 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DLD53_11960 ENOG41079KZ Major Facilitator Superfamily DLD53_11965 ENOG4105EN6 Membrane DLD53_11975 ENOG4105EE5 Membrane protein terC DLD53_11980 ENOG4108URH decarboxylase DLD53_11985 ENOG4105C0R drug resistance transporter emrb qaca subfamily DLD53_11995 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DLD53_12010 ENOG4105CCT upf0313 protein DLD53_12030 ENOG4105CS1 NAD(P)H quinone oxidoreductase DLD53_12040 ENOG4105C6T cysteine synthase DLD53_12075 ENOG4105Y7M Transcriptional regulator, TetR family DLD53_12110 ENOG4105C79 DNA protecting protein DprA DLD53_12125 ENOG4108IND Tetr family transcriptional regulator DLD53_12130 ENOG4107RTG Major Facilitator superfamily DLD53_12140 ENOG4108V06 Glutathione peroxidase DLD53_12180 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DLD53_12205 ENOG4105FDK ABC transporter DLD53_12210 ENOG4105FAV ABC, transporter DLD53_12220 ENOG4105EZR dyp-type peroxidase family protein DLD53_12230 ENOG4107R1I NAD-dependent malic enzyme DLD53_12255 ENOG4105EUB pirin domain protein DLD53_12275 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DLD53_12280 ENOG4106MP8 UPF0754 membrane protein DLD53_12285 ENOG4108VBZ doxx family DLD53_12290 ENOG4105DQR SNARE associated Golgi DLD53_12305 ENOG4107QJE Chromosome Partitioning Protein DLD53_12315 ENOG4107PSF BolA-like protein DLD53_12335 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DLD53_12360 ENOG4105C1G acyl-Coa dehydrogenase DLD53_12385 ENOG4105CSH Transporter DLD53_12390 ENOG4105E39 Enoyl-CoA hydratase DLD53_12395 ENOG4105E39 Enoyl-CoA hydratase DLD53_12400 ENOG4105C1G acyl-Coa dehydrogenase DLD53_12410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DLD53_12415 ENOG4105C26 Dehydrogenase DLD53_12425 ENOG4105C85 amino acid DLD53_12430 ENOG4105C85 amino acid DLD53_12435 ENOG4105M4H endoribonuclease L-psp DLD53_12450 ENOG4105EW9 transcriptional regulator AsnC family DLD53_12475 ENOG4105D3G Pseudouridine synthase DLD53_12505 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DLD53_12525 ENOG4108I0Z Aconitate hydratase DLD53_12530 ENOG4105BZN citrate synthase DLD53_12535 ENOG4105CR4 methylisocitrate lyase DLD53_12540 ENOG4105DRR Transcriptional regulator, GntR family DLD53_12550 ENOG4105CGF Aromatic amino acid aminotransferase DLD53_12555 ENOG4105CXG d-lactate dehydrogenase DLD53_12565 ENOG41073TP transcriptional regulator DLD53_12570 ENOG4105DAA L-lactate DLD53_12575 ENOG4107QKV phosphomannomutase DLD53_12580 ENOG4105CMR udp-glucose 4-epimerase DLD53_12590 ENOG4105C6Y Udp-glucose 6-dehydrogenase DLD53_12595 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DLD53_12600 ENOG4105D3Q Sugar transferase DLD53_12605 ENOG4107UKG Glycosyl transferase, family 4 DLD53_12620 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DLD53_12660 ENOG4107QQG Dehydrogenase DLD53_12665 ENOG4105DAY polysaccharide export protein DLD53_12675 ENOG4105D75 Capsular exopolysaccharide family DLD53_12680 ENOG4108V1T peptidylprolyl cis-trans isomerase DLD53_12685 ENOG4108V1T peptidylprolyl cis-trans isomerase DLD53_12690 ENOG4105CJR Integral membrane protein (MviN DLD53_12695 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DLD53_12700 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DLD53_12710 ENOG4105HSS phospholipase C DLD53_12740 ENOG41062JF Transcriptional regulator DLD53_12755 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DLD53_12760 ENOG4105UBK short-chain dehydrogenase reductase DLD53_12775 ENOG4107QZM n-acetylglutamate synthase DLD53_12780 ENOG4105GVF (ABC) transporter DLD53_12785 ENOG4105GVF (ABC) transporter DLD53_12790 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DLD53_12795 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DLD53_12800 ENOG4108VM9 ABC, transporter DLD53_12805 ENOG4108R86 Transcriptional regulator DLD53_12810 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DLD53_12820 ENOG4105DTN riboflavin biosynthesis protein ribF DLD53_12825 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DLD53_12835 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase DLD53_12880 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DLD53_12885 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DLD53_12890 ENOG4105D74 hydrolase DLD53_12900 ENOG4108821 RND type efflux pump DLD53_12905 ENOG4108821 RND type efflux pump DLD53_12910 ENOG4108821 RND type efflux pump DLD53_12915 ENOG4105C5H ABC transporter DLD53_12920 ENOG4105DQR SNARE associated Golgi DLD53_12930 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DLD53_12940 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DLD53_12950 ENOG4105VG0 50S ribosomal protein l34 DLD53_12965 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DLD53_12980 ENOG4105PGM cation diffusion facilitator family transporter DLD53_12985 ENOG4105T95 Thiol disulfide interChange protein DLD53_12995 ENOG4108UGV hypoxanthine phosphoribosyltransferase DLD53_13000 ENOG4107QUY Guanine deaminase DLD53_13010 ENOG4106032 Glutathionylspermidine synthase DLD53_13025 ENOG4105DU1 integral membrane protein, terc DLD53_13030 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DLD53_13040 ENOG4105DFU Cell wall formation (By similarity) DLD53_13055 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DLD53_13060 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DLD53_13065 ENOG4105CVE Lytic murein transglycosylase DLD53_13120 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DLD53_13180 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DLD53_13210 ENOG4105C2W permease DLD53_13220 ENOG4108IG5 Transcriptional regulator DLD53_13225 ENOG4105DJY efflux transporter, rnd family, mfp subunit DLD53_13260 ENOG4105F27 Major Facilitator DLD53_13265 ENOG4105CV8 reductase DLD53_13270 ENOG4105HEI LysR family (Transcriptional regulator DLD53_13290 ENOG4105DQ4 alcohol dehydrogenase DLD53_13295 ENOG4108R3E Dna-3-methyladenine glycosylase i DLD53_13310 ENOG4105CEN a g-specific adenine glycosylase DLD53_13330 ENOG4108ZZ3 UPF0260 protein DLD53_13340 ENOG4105D1H recombination factor protein RarA DLD53_13345 ENOG4105S64 Formate nitrite transporter DLD53_13370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DLD53_13375 ENOG4108RWI nicotinamidase DLD53_13380 ENOG4105C09 Bile acid DLD53_13385 ENOG4107QI1 Mate efflux family protein DLD53_13390 ENOG4105EWC Purine nucleoside phosphorylase DLD53_13410 ENOG4108RXX maleylacetoacetate isomerase DLD53_13420 ENOG4105C85 amino acid DLD53_13430 ENOG4105CKI cobalamin synthesis protein DLD53_13440 ENOG4105CZE histidine utilization repressor DLD53_13445 ENOG41090B9 response to stress DLD53_13460 ENOG4105C85 amino acid DLD53_13470 ENOG41088SP formiminoglutamate hydrolase DLD53_13480 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DLD53_13485 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DLD53_13490 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DLD53_13500 ENOG4108ZAI phosphatidylglycerophosphatase a DLD53_13505 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DLD53_13520 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DLD53_13570 ENOG4105KHC sulfurtransferase DLD53_13580 ENOG4107SCA Formamidase (EC 3.5.1.49) DLD53_13595 ENOG4105BZU Histidine kinase DLD53_13600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DLD53_13615 ENOG4107QJQ Mate efflux family protein DLD53_13620 ENOG4105CHM Aminotransferase DLD53_13625 ENOG4106BRA Membrane DLD53_13640 ENOG4105D9M gamma-glutamylcysteine synthetase DLD53_13650 ENOG4105CS6 Rhs element vgr protein DLD53_13655 ENOG4105NVB glycoside hydrolase, family 19 DLD53_13680 ENOG4105IPS esterase DLD53_13685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DLD53_13690 ENOG4108Z2U ureidoglycolate hydrolase DLD53_13700 ENOG41061H0 Monooxygenase DLD53_13745 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DLD53_13765 ENOG4105KUZ arsenate reductase DLD53_13770 ENOG4105CGK Exodeoxyribonuclease III DLD53_13790 ENOG4105D7Z glutathione synthase DLD53_13810 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) DLD53_13815 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DLD53_13820 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DLD53_13835 ENOG41063SB peptidase DLD53_13840 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DLD53_13845 ENOG4107QSN dihydrolipoamide acetyltransferase DLD53_13865 ENOG4105F9F transposase DLD53_13885 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DLD53_13900 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DLD53_13920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DLD53_13925 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase DLD53_13935 ENOG4105D64 Mechanosensitive ion channel DLD53_13945 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DLD53_13950 ENOG4108W2Y isochorismatase DLD53_13960 ENOG4105FBW Monooxygenase DLD53_13965 ENOG4108UZX fmn reductase DLD53_13980 ENOG4105BZU Histidine kinase DLD53_13985 ENOG41062QD Membrane DLD53_13990 ENOG4107QN1 sodium solute DLD53_14000 ENOG4105C94 Transporter DLD53_14010 ENOG4105BZU Histidine kinase DLD53_14015 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DLD53_14020 ENOG4108WUH Transcriptional regulator, TetR family DLD53_14025 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DLD53_14035 ENOG4105RA2 Membrane DLD53_14040 ENOG4105DWF phosphomethylpyrimidine kinase DLD53_14050 ENOG4107RDB Major Facilitator DLD53_14055 ENOG4108UUM single-stranded DNA-binding protein DLD53_14065 ENOG4108UMN azlc family DLD53_14075 ENOG4105C85 amino acid DLD53_14085 ENOG4108JPW Aminotransferase DLD53_14090 ENOG4105C26 Dehydrogenase DLD53_14100 ENOG4105CHJ isochorismatase hydrolase DLD53_14105 ENOG4105EUB pirin domain protein DLD53_14130 ENOG4105D94 Major Facilitator Superfamily DLD53_14135 ENOG4106NZI LysR family Transcriptional regulator DLD53_14160 ENOG4105CPC Aldo Keto reductase DLD53_14165 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) DLD53_14185 ENOG4105KVH Transcriptional regulator DLD53_14200 ENOG4105KVH Transcriptional regulator DLD53_14210 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DLD53_14225 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain DLD53_14230 ENOG4108UQN AraC family transcriptional regulator DLD53_14285 ENOG4105CUV Homoserine Kinase DLD53_14325 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DLD53_14355 ENOG4105CYC Transferase DLD53_14365 ENOG4105E0F Histidine kinase DLD53_14370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DLD53_14380 ENOG4105CHH sulfate transporter DLD53_14385 ENOG4105PDP Short chain dehydrogenase DLD53_14395 ENOG4105C5H ABC transporter DLD53_14460 ENOG4108IQI permease DLD53_14485 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DLD53_14500 ENOG4105CJN penicillin-binding protein DLD53_14505 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DLD53_14510 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) DLD53_14525 ENOG4105DHI Methyltransferase DLD53_14530 ENOG4108JQC penicillin-binding protein 1A DLD53_14555 ENOG4105E4G Type IV pilus DLD53_14575 ENOG4105CBC glutamate synthase DLD53_14580 ENOG4105BZ8 glutamate synthase DLD53_14590 ENOG4108V0P LemA family DLD53_14595 ENOG4105HA9 of methanol dehydrogenase type DLD53_14615 ENOG4108YSG O-Antigen polymerase DLD53_14620 ENOG4108UQY Iron-storage protein DLD53_14630 ENOG4105KME endoribonuclease L-psp DLD53_14635 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DLD53_14650 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DLD53_14705 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DLD53_14720 ENOG4107IFA Lipase (EC 3.1.1.3) DLD53_14725 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) DLD53_14730 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DLD53_14755 ENOG4108JQ1 Dehydrogenase DLD53_14760 ENOG4105CQB FAD linked oxidase domain protein DLD53_14770 ENOG4105VRH Antibiotic biosynthesis monooxygenase DLD53_14775 ENOG4105NF4 modulator of drug activity DLD53_14785 ENOG4107QF7 multi-drug DLD53_14790 ENOG4105EM2 membrane DLD53_14795 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DLD53_14800 ENOG4105IPI Membrane DLD53_14805 ENOG4107SKI cobyrinic Acid a,c-diamide synthase DLD53_14835 ENOG4108IQI permease DLD53_14840 ENOG4105D82 Glutamate dehydrogenase DLD53_14845 ENOG4105C8Y Acetylornithine aminotransferase DLD53_14855 ENOG4105C26 Dehydrogenase DLD53_14880 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DLD53_14940 ENOG4105W87 Cbs domain DLD53_14945 ENOG41067S9 phage shock protein C, PspC DLD53_14955 ENOG4105CSU acyl-Coa dehydrogenase DLD53_14970 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) DLD53_14985 ENOG4105ECY inositol monophosphatase DLD53_14990 ENOG4105C1J atp-dependent rna helicase DLD53_14995 ENOG4105DHJ ABC, transporter DLD53_15000 ENOG4105CY3 ABC transporter, permease DLD53_15010 ENOG4105E3I toluene tolerance DLD53_15020 ENOG4105D7N magnesium and cobalt transport protein CorA DLD53_15025 ENOG4108URH decarboxylase DLD53_15035 ENOG4105MJ2 Competence protein DLD53_15040 ENOG4105CB5 ATP-dependent DNA helicase recG DLD53_15060 ENOG4105C29 acyl-CoA thioesterase DLD53_15065 ENOG4105CK2 sodium dicarboxylate symporter DLD53_15080 ENOG4105KPV Transcriptional regulator DLD53_15090 ENOG4105D7A ATP-binding protein DLD53_15095 ENOG4105C28 cystathionine DLD53_15100 ENOG41089BK Glutamine amido-transferase DLD53_15210 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DLD53_15215 ENOG41067V7 50S ribosomal protein L36 DLD53_15225 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DLD53_15250 ENOG4105C1G acyl-Coa dehydrogenase DLD53_15285 ENOG4105VKU nucleicacid-binding protein DLD53_15290 ENOG4105DGW oligopeptidase A DLD53_15295 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DLD53_15335 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DLD53_15340 ENOG4108K2B transcriptional regulator DLD53_15350 ENOG4107S2Z UPF0761 membrane protein DLD53_15355 ENOG4105CS1 NAD(P)H quinone oxidoreductase DLD53_15385 ENOG4105C9A Phoh family DLD53_15395 ENOG4105E4C Lytic transglycosylase catalytic DLD53_15425 ENOG4105D6S protein involved in catabolism of external DNA DLD53_15430 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DLD53_15475 ENOG4105C1G acyl-Coa dehydrogenase DLD53_15480 ENOG4108RZE Tetr family transcriptional regulator DLD53_15495 ENOG4107QX3 carboxylase DLD53_15500 ENOG4105C1G acyl-Coa dehydrogenase DLD53_15520 ENOG4105KB2 stringent starvation protein b DLD53_15525 ENOG4107MKT Stringent starvation protein a DLD53_15530 ENOG4108UJD 30S ribosomal protein S9 DLD53_15540 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DLD53_15545 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DLD53_15550 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DLD53_15570 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DLD53_15580 ENOG4107RZC phospholipase d DLD53_15590 ENOG4105UYK outer membrane protein a DLD53_15595 ENOG4108KHX Diguanylate cyclase DLD53_15605 ENOG4105F9F transposase DLD53_15635 ENOG4107QN2 dihydrolipoyl dehydrogenase DLD53_15645 ENOG4107QPB Beta-lactamase domain protein DLD53_15650 ENOG4107U2T alpha beta DLD53_15660 ENOG4105NAU thioesterase Superfamily protein DLD53_15690 ENOG4105K9H YciI-like protein DLD53_15700 ENOG4105DB7 PHP domain protein DLD53_15705 ENOG4105FFC UPF0187 protein DLD53_15715 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DLD53_15720 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DLD53_15725 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DLD53_15730 ENOG4105VIE preprotein translocase, subunit YajC DLD53_15760 ENOG4105F9F transposase DLD53_15780 ENOG4105BZU Histidine kinase DLD53_15785 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DLD53_15790 ENOG4105CM2 brancheD-chain amino acid aminotransferase DLD53_15805 ENOG4107BJW polysaccharide deacetylase DLD53_15815 ENOG4108PQP glycosyl transferase group 1 DLD53_15865 ENOG4105UGU tonB-dependent Receptor DLD53_15885 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DLD53_15890 ENOG4108K3A Glutathione S-transferase DLD53_15895 ENOG4108R4R Iron-regulated virulence regulatory protein DLD53_15900 ENOG4105CSU acyl-Coa dehydrogenase DLD53_15905 ENOG4105CSU acyl-Coa dehydrogenase DLD53_15915 ENOG4105EB3 Histidine kinase DLD53_15920 ENOG4105E3W Two component transcriptional regulator (Winged helix family DLD53_15925 ENOG4105CNG UPF0061 protein DLD53_15945 ENOG4108WBT adenosyltransferase DLD53_15960 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DLD53_15995 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DLD53_16015 ENOG4105D3R alkyl hydroperoxide reductase DLD53_16030 ENOG4105CSH Transporter DLD53_16035 ENOG4108UT2 hemolysin iii DLD53_16065 ENOG4105CHU acetyl-coa acetyltransferase DLD53_16070 ENOG4108R6W Transcriptional regulator, ARAC family DLD53_16080 ENOG4105TW1 Carbohydrate-selective porin OprB DLD53_16085 ENOG4105DZG Dehydrogenase DLD53_16090 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DLD53_16110 ENOG4105CHU acetyl-coa acetyltransferase DLD53_16120 ENOG4108WHA ompa motb domain protein DLD53_16130 ENOG4105E0Y RtcB Protein DLD53_16135 ENOG4108IQI permease DLD53_16165 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DLD53_16175 ENOG4108VX5 3-methyladenine DNA glycosylase DLD53_16180 ENOG4105CHB tonB-dependent Receptor DLD53_16185 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DLD53_16190 ENOG4108N2Y auxin Efflux DLD53_16200 ENOG4105T95 Thiol disulfide interChange protein DLD53_16205 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DLD53_16215 ENOG4105K78 MarR family Transcriptional regulator DLD53_16220 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DLD53_16225 ENOG4105KWI UPF0339 protein DLD53_16250 ENOG4108UNF response regulator DLD53_16255 ENOG4105M3Z response regulator DLD53_16260 ENOG4108ZGA chew protein DLD53_16265 ENOG4105C8Q Methyl-accepting chemotaxis DLD53_16270 ENOG4105CBS Chea signal transduction histidine kinase DLD53_16285 ENOG4106HKS Entericidin EcnA/B family DLD53_16295 ENOG4105WD1 Membrane DLD53_16300 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DLD53_16340 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DLD53_16350 ENOG4105EM2 membrane DLD53_16355 ENOG4105C2C drug resistance transporter, Bcr CflA DLD53_16375 ENOG4105BZG amino acid carrier protein DLD53_16380 ENOG4105D78 K07001 NTE family protein DLD53_16385 ENOG4105C7B Threonine dehydratase DLD53_16420 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DLD53_16430 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DLD53_16435 ENOG4105DFF Rod shape-determining protein mreb DLD53_16440 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DLD53_16445 ENOG4105VQ7 Rod shape-determining protein MreD DLD53_16450 ENOG4108Z03 MAF-like protein DLD53_16455 ENOG4105C03 ribonuclease DLD53_16465 ENOG4105D8T Acyltransferase DLD53_16475 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein DLD53_16485 ENOG4108X0B nad(p)h dehydrogenase (quinone) DLD53_16510 ENOG4105CF7 AraC family transcriptional regulator DLD53_16625 ENOG4105CDU Replicative dna helicase DLD53_16680 ENOG4105MEW serine threonine protein phosphatase DLD53_16840 ENOG4105UPP uncharacterized protein ydcA DLD53_16945 ENOG4105C85 amino acid DLD53_16950 ENOG4105C7F AcnD-accessory protein PrpF DLD53_16955 ENOG4105CTB Polyprenyl synthetase DLD53_16960 ENOG4105MSB protein, conserved in bacteria DLD53_16975 ENOG4105D78 K07001 NTE family protein DLD53_16995 ENOG4105DIJ Phosphoethanolamine transferase DLD53_17000 ENOG4105XJC Two component transcriptional regulator (Winged helix family DLD53_17005 ENOG4105DHQ Histidine kinase DLD53_17025 ENOG4108M0I Transcriptional regulator DLD53_17045 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DLD53_17065 ENOG4105K8R UPF0145 protein DLD53_17070 ENOG4105K8R UPF0145 protein DLD53_17075 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DLD53_17080 ENOG4105BZS acriflavin resistance protein DLD53_17085 ENOG4105C1P efflux transporter, rnd family, mfp subunit DLD53_17090 ENOG410841Q phosphoesterase PA-phosphatase related protein DLD53_17120 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) DLD53_17135 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DLD53_17140 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DLD53_17145 ENOG4105KVH Transcriptional regulator DLD53_17155 ENOG4105CUB amino acid DLD53_17170 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DLD53_17175 ENOG41084BA UPF0250 protein DLD53_17180 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DLD53_17215 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit DLD53_17220 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein DLD53_17230 ENOG4105E33 succinate dehydrogenase DLD53_17245 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DLD53_17250 ENOG4105C7S Dehydrogenase DLD53_17255 ENOG4107QN2 dihydrolipoyl dehydrogenase DLD53_17265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DLD53_17275 ENOG4105CKW Inner membrane protein yedI DLD53_17280 ENOG4105CGZ zinc metallopeptidase DLD53_17285 ENOG4105EEQ Na H antiporter DLD53_17330 ENOG4105PNM synthesis protein DLD53_17345 ENOG41080TK Universal stress protein DLD53_17360 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DLD53_17365 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DLD53_17380 ENOG4105HBR Rna-binding protein DLD53_17390 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DLD53_17395 ENOG4105EEI dihydropteroate synthase DLD53_17445 ENOG4105CSH Transporter DLD53_17450 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DLD53_17455 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DLD53_17470 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DLD53_17490 ENOG41080IJ Diacylglycerol kinase DLD53_17500 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DLD53_17520 ENOG4105E4C Lytic transglycosylase catalytic DLD53_17545 ENOG4108RRZ Transcription elongation factor GreB DLD53_17560 ENOG4105CEY Amp-dependent synthetase and ligase DLD53_17605 ENOG4105BZW Glycerate kinase DLD53_17610 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit DLD53_17615 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DLD53_17630 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) DLD53_17640 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DLD53_17645 ENOG4105C85 amino acid DLD53_17655 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DLD53_17665 ENOG4105N14 lysine exporter protein LysE YggA DLD53_17670 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DLD53_17675 ENOG4105BZJ Electron transfer flavoprotein DLD53_17680 ENOG4105C10 Electron transfer flavoprotein DLD53_17685 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DLD53_17720 ENOG4107KET secretion protein, HlyD family DLD53_17750 ENOG4105D60 lipoprotein releasing system transmembrane protein DLD53_17755 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DLD53_17760 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DLD53_17770 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DLD53_17775 ENOG4107R6F Alpha Beta Hydrolase Fold protein DLD53_17780 ENOG4108V3E phosphoribosylglycinamide formyltransferase DLD53_17790 ENOG4105C02 permease DLD53_17840 ENOG4105KCK Peptidoglycan-associated lipoprotein DLD53_17845 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DLD53_17855 ENOG4105M8F Biopolymer transport protein exbD tolR DLD53_17860 ENOG4105E02 MotA TolQ exbB proton channel DLD53_17865 ENOG4107YD3 Thioesterase DLD53_17870 ENOG4105CH2 amidohydrolase DLD53_17890 ENOG4108ETH Formylglycinamide ribotide synthetase DLD53_17895 ENOG4105C2C drug resistance transporter, Bcr CflA DLD53_17900 ENOG4105EGD dinuclear metal center protein, YbgI family DLD53_17905 ENOG4108UKI Enoyl-CoA hydratase DLD53_17920 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DLD53_17935 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DLD53_17940 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DLD53_17955 ENOG4107R11 Transcriptional regulator DLD53_17960 ENOG4108IJ6 ABC transporter DLD53_17970 ENOG4108I5D sulfate abc transporter DLD53_17980 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DLD53_17985 ENOG4105YAZ 4-amino-4-deoxychorismate lyase DLD53_17990 ENOG4105HHA aminodeoxychorismate lyase DLD53_18005 ENOG4108IYU L-aspartate oxidase DLD53_18010 ENOG4105C0H protease DLD53_18025 ENOG4105C3F Signal peptidase i DLD53_18040 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DLD53_18050 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DLD53_18055 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DLD53_18060 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase DLD53_18065 ENOG4105EMU Dehydrogenase DLD53_18105 ENOG4105BZU Histidine kinase DLD53_18115 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DLD53_18125 ENOG4105DTR rard protein DLD53_18160 ENOG4107QS8 (LipO)protein DLD53_18165 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DLD53_18170 ENOG4105EA8 2-Nitropropane dioxygenase DLD53_18200 ENOG4107R8N Glycosyl transferase, family 2 DLD53_18215 ENOG4105CVP deoxyribo-dipyrimidine photolyase DLD53_18220 ENOG4108YZY peptidylprolyl cis-trans isomerase DLD53_18225 ENOG4105CEP NADH dehydrogenase DLD53_18230 ENOG4105DZ1 carboxypeptidase DLD53_18240 ENOG4105E9K Isocitrate dehydrogenase DLD53_18245 ENOG4108R99 pseudouridine synthase DLD53_18270 ENOG4105CBP Major Facilitator DLD53_18275 ENOG4105EGI Transcriptional regulator DLD53_18280 ENOG4108ETY sodium dicarboxylate symporter DLD53_18285 ENOG4105JAB phenazine biosynthesis protein, phzf family DLD53_18315 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DLD53_18330 ENOG4105D3G Pseudouridine synthase DLD53_18335 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) DLD53_18350 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DLD53_18375 ENOG4108JPW Aminotransferase DLD53_18380 ENOG4105DY8 decarboxylase DLD53_18390 ENOG4105F7P transcriptional regulator AsnC family DLD53_18395 ENOG4107RA9 decarboxylase DLD53_18400 ENOG4105C85 amino acid DLD53_18405 ENOG4105CVA phosphate DLD53_18410 ENOG4105C8U phosphate abc transporter DLD53_18420 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DLD53_18425 ENOG4105ERU peptidase DLD53_18440 ENOG4107QTF adenylosuccinate lyase DLD53_18460 ENOG4108Z0R Transferase DLD53_18465 ENOG4105DZ1 carboxypeptidase DLD53_18485 ENOG4108K5P (LipO)protein DLD53_18490 ENOG4105EJC lysr family transcriptional regulator DLD53_18495 ENOG4105DAN ATP-dependent protease DLD53_18510 ENOG4105DHU Bile acid DLD53_18530 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DLD53_18540 ENOG4105D22 carbon starvation protein DLD53_18545 ENOG4105VCD cytoplasmic protein DLD53_18660 ENOG4105CDU Replicative dna helicase DLD53_18915 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DLD53_18945 ENOG4108K8K Transcriptional regulator DLD53_18960 ENOG4105C26 Dehydrogenase DLD53_18965 ENOG4105C85 amino acid DLD53_18985 ENOG4105C94 Transporter DLD53_18990 ENOG4105C94 Transporter DLD53_19000 ENOG4105C26 Dehydrogenase DLD53_19005 ENOG4107QZF nitrite reductase NADPH large subunit DLD53_19010 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) DLD53_19035 ENOG4105F9F transposase DLD53_19050 ENOG41060M8 Pfam:PhdYeFM DLD53_19055 ENOG4107QNK )-transporter DLD53_19060 ENOG4107WEA mandelate racemase muconate lactonizing DLD53_19070 ENOG4105J7D transcriptional regulator DLD53_19090 ENOG4105C2I pirin domain protein DLD53_19100 ENOG4105WWK YheO domain protein DLD53_19115 ENOG4105CEY Amp-dependent synthetase and ligase DLD53_19130 ENOG4108IPW abc transporter atp-binding protein DLD53_19150 ENOG4105C0W non-ribosomal peptide synthetase DLD53_19155 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DLD53_19160 ENOG4105WQI isochorismatase DLD53_19175 ENOG4105BZ1 (ABC) transporter DLD53_19195 ENOG4105E4F Isochorismate synthase DLD53_19210 ENOG4105NX3 Membrane DLD53_19235 ENOG4105EUJ GTP cyclohydrolase i DLD53_19245 ENOG4105C7W Xanthine dehydrogenase DLD53_19275 ENOG4105CD8 aminopeptidase N DLD53_19280 ENOG4105DDQ anthranilate synthase DLD53_19360 ENOG41067QW Transcriptional regulator DLD53_19525 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DLD53_19565 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DLD53_19590 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DLD53_19625 ENOG4106J5W DNA polymerase III (alpha subunit) DLD53_19645 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DLD53_19690 ENOG4105EYH Exonuclease DLD53_19720 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DLD53_19725 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DLD53_19750 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DLD53_19995 ENOG4108ES9 ParB domain protein nuclease DLD53_20000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DLD53_20110 ENOG4107TT5 NLP P60 protein DLD53_20170 ENOG4105KK6 nuclease DLD53_20175 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS DLD53_20235 ENOG4105FA0 parb-like partition protein DLD53_20255 ENOG4105CDW Resistance protein DLD53_20270 ENOG4105F9F transposase DLD53_20280 ENOG4105F9F transposase DLD53_20365 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DLD53_20420 ENOG4105F9F transposase DLD53_20460 ENOG4105K5T PilT protein DLD53_20495 ENOG4105T95 Thiol disulfide interChange protein DLD53_20575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DLD53_20670 ENOG4105UGU tonB-dependent Receptor