locus-tag	class	description
KU039_00010	COG0592	DNA-directed DNA polymerase activity
KU039_00020	COG0187	DNA topoisomerase II activity
KU039_00030	COG0586	Pfam SNARE associated Golgi protein
KU039_00035	COG0488	(ABC) transporter
KU039_00060	COG0596	Alpha beta hydrolase
KU039_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KU039_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KU039_00110	COG0733	neurotransmitter:sodium symporter activity
KU039_00150	COG2233	PERMEase
KU039_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU039_00200	COG2814	Major facilitator Superfamily
KU039_00205	COG0656	L-ascorbic acid biosynthetic process
KU039_00210	COG0583	DNA-binding transcription factor activity
KU039_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU039_00230	COG1064	alcohol dehydrogenase
KU039_00235	COG2818	Glycosylase
KU039_00250	COG1194	a g-specific adenine glycosylase
KU039_00270	COG2983	Belongs to the UPF0260 family
KU039_00275	COG2133	pyrroloquinoline quinone binding
KU039_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KU039_00285	COG2116	formate transmembrane transporter activity
KU039_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU039_00310	COG1335	isochorismatase
KU039_00315	COG0385	Bile acid
KU039_00320	COG0534	Mate efflux family protein
KU039_00325	COG1683	Conserved Protein
KU039_00345	COG0625	glutathione transferase activity
KU039_00355	COG1113	amino acid transport
KU039_00365	COG0523	cobalamin synthesis protein
KU039_00375	COG2188	Transcriptional regulator
KU039_00405	COG0010	Belongs to the arginase family
KU039_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KU039_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KU039_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KU039_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KU039_00540	COG0534	Mate efflux family protein
KU039_00545	COG0436	Aminotransferase
KU039_00550	COG2733	membrane
KU039_00565	COG2918	glutathione biosynthetic process
KU039_00580	COG0791	NLP P60 protein
KU039_00580	COG1388	LysM domain
KU039_00595	COG3150	esterase
KU039_00605	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KU039_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU039_00630	COG2233	PERMEase
KU039_00635	COG2351	hydroxyisourate hydrolase activity
KU039_00670	COG3706	GGDEF domain
KU039_00685	COG1393	Belongs to the ArsC family
KU039_00690	COG0708	Exodeoxyribonuclease III
KU039_00710	COG0189	ligase activity
KU039_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KU039_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KU039_00755	COG4942	peptidase
KU039_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU039_00775	COG2119	membrane
KU039_00780	COG4774	siderophore transport
KU039_00785	COG0426	domain, Protein
KU039_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU039_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KU039_00830	COG1902	pentaerythritol trinitrate reductase activity
KU039_00835	COG1519	Transferase
KU039_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU039_00845	COG0668	transmembrane transport
KU039_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU039_00860	COG1335	isochorismatase
KU039_00865	COG1522	sequence-specific DNA binding
KU039_00870	COG3328	transposase activity
KU039_00895	COG2205	protein histidine kinase activity
KU039_00895	COG2198	Histidine kinase
KU039_00895	COG0784	Response regulator, receiver
KU039_00900	COG3162	membrane
KU039_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU039_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU039_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KU039_00940	COG1309	transcriptional regulator
KU039_00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KU039_00965	COG0352	thiamine-phosphate diphosphorylase activity
KU039_00965	COG0351	phosphomethylpyrimidine kinase
KU039_00975	COG2814	Major facilitator Superfamily
KU039_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KU039_01000	COG1113	amino acid transport
KU039_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KU039_01015	COG1012	belongs to the aldehyde dehydrogenase family
KU039_01025	COG1335	isochorismatase
KU039_01055	COG2814	Major facilitator Superfamily
KU039_01060	COG0583	DNA-binding transcription factor activity
KU039_01080	COG0667	Aldo Keto reductase
KU039_01115	COG1733	regulation of RNA biosynthetic process
KU039_01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU039_01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KU039_01205	COG2329	Antibiotic biosynthesis monooxygenase
KU039_01235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KU039_01265	COG0427	acetyl-CoA hydrolase
KU039_01290	COG0659	secondary active sulfate transmembrane transporter activity
KU039_01295	COG4221	oxidoreductase activity
KU039_01300	COG2873	o-acetylhomoserine
KU039_01305	COG0488	(ABC) transporter
KU039_01390	COG0833	amino acid
KU039_01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KU039_01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KU039_01455	COG2226	methyltransferase
KU039_01505	COG0067	glutamate synthase
KU039_01505	COG0070	glutamate synthase
KU039_01505	COG0069	glutamate synthase activity
KU039_01510	COG0493	'glutamate synthase
KU039_01520	COG1704	LemA family
KU039_01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KU039_01545	COG3307	-O-antigen
KU039_01570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU039_01585	COG0194	GDP metabolic process
KU039_01635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KU039_01655	COG5380	lipid catabolic process
KU039_01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KU039_01685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KU039_01690	COG0277	FAD linked oxidase domain protein
KU039_01700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KU039_01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU039_01720	COG1289	transmembrane transporter activity
KU039_01730	COG0628	permease
KU039_01735	COG1192	Involved in chromosome partitioning
KU039_01765	COG0833	amino acid
KU039_01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU039_01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KU039_01785	COG1012	belongs to the aldehyde dehydrogenase family
KU039_01825	COG0583	DNA-binding transcription factor activity
KU039_01875	COG0517	IMP dehydrogenase activity
KU039_01880	COG1983	PspC domain protein
KU039_01890	COG1960	acyl-CoA dehydrogenase activity
KU039_01905	COG0408	coproporphyrinogen oxidase activity
KU039_01925	COG0513	Belongs to the DEAD box helicase family
KU039_01935	COG1127	ABC transporter
KU039_01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KU039_01950	COG2854	intermembrane phospholipid transfer
KU039_01960	COG0598	Magnesium transport protein CorA
KU039_01970	COG0494	nUDIX hydrolase
KU039_01975	COG1040	competence protein
KU039_01980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KU039_02000	COG1946	Acyl-CoA thioesterase
KU039_02005	COG1301	dicarboxylic acid transport
KU039_02020	COG1959	2 iron, 2 sulfur cluster binding
KU039_02025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU039_02025	COG1017	nitric oxide dioxygenase activity
KU039_02030	COG0433	COG0433 Predicted ATPase
KU039_02035	COG0626	cystathionine gamma-synthase activity
KU039_02190	COG1960	acyl-CoA dehydrogenase activity
KU039_02195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KU039_02225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KU039_02230	COG0339	signal peptide processing
KU039_02235	COG0557	exoribonuclease II activity
KU039_02280	COG0179	Fumarylacetoacetate (FAA) hydrolase
KU039_02285	COG2169	Transcriptional regulator
KU039_02290	COG0697	spore germination
KU039_02295	COG1295	ribonuclease BN
KU039_02330	COG1702	phosphate starvation-inducible protein PhoH
KU039_02340	COG0739	heme binding
KU039_02340	COG0741	lytic transglycosylase activity
KU039_02340	COG1196	nuclear chromosome segregation
KU039_02370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KU039_02375	COG1183	phosphatidylcholine synthase activity
KU039_02420	COG1960	acyl-CoA dehydrogenase activity
KU039_02425	COG1309	transcriptional regulator
KU039_02440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KU039_02445	COG1960	acyl-CoA dehydrogenase activity
KU039_02465	COG2969	positive regulation of protein catabolic process
KU039_02475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KU039_02490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KU039_02495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KU039_02515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KU039_02525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU039_02530	COG1408	metallophosphoesterase
KU039_02540	COG2199	diguanylate cyclase activity
KU039_02600	COG1607	acyl-coa hydrolase
KU039_02630	COG2350	Protein conserved in bacteria
KU039_02640	COG0613	PHP domain protein
KU039_02645	COG3781	membrane
KU039_02655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KU039_02660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KU039_02670	COG1862	Preprotein translocase
KU039_02700	COG2205	protein histidine kinase activity
KU039_02705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KU039_02725	COG0726	polysaccharide deacetylase
KU039_02730	COG0463	Glycosyl transferase, family 2
KU039_02735	COG0438	transferase activity, transferring glycosyl groups
KU039_02800	COG0625	glutathione transferase activity
KU039_02805	COG0583	DNA-binding transcription factor activity
KU039_02810	COG1960	acyl-CoA dehydrogenase activity
KU039_02815	COG1960	acyl-CoA dehydrogenase activity
KU039_02825	COG2205	protein histidine kinase activity
KU039_02830	COG0745	RESPONSE REGULATOR receiver
KU039_02835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KU039_02855	COG2096	Adenosyltransferase
KU039_02905	COG0285	dihydrofolate synthase activity
KU039_02925	COG0450	alkyl hydroperoxide reductase
KU039_02940	COG0477	Major facilitator Superfamily
KU039_02945	COG1272	protein, Hemolysin III
KU039_02975	COG0183	Belongs to the thiolase family
KU039_02980	COG2207	Transcriptional regulator
KU039_03000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU039_03020	COG0183	Belongs to the thiolase family
KU039_03030	COG2885	chlorophyll binding
KU039_03030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KU039_03040	COG1690	Belongs to the RtcB family
KU039_03045	COG0833	amino acid
KU039_03055	COG2233	PERMEase
KU039_03060	COG1217	gtp-binding protein TYPA
KU039_03085	COG2094	Belongs to the DNA glycosylase MPG family
KU039_03090	COG4772	TonB-dependent receptor
KU039_03105	COG1902	pentaerythritol trinitrate reductase activity
KU039_03120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU039_03125	COG0354	folic acid binding
KU039_03135	COG3189	MarR family transcriptional regulator
KU039_03140	COG2824	Alkylphosphonate utilization operon protein PhnA
KU039_03145	COG3422	double-strand break repair
KU039_03185	COG0840	transmembrane signaling receptor activity
KU039_03205	COG5510	response to toxic substance
KU039_03215	COG2832	Protein of unknown function (DUF454)
KU039_03220	COG1376	ErfK ybiS ycfS ynhG family protein
KU039_03260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KU039_03270	COG1289	transmembrane transporter activity
KU039_03275	COG2814	Major facilitator Superfamily
KU039_03295	COG1115	amino acid carrier protein
KU039_03300	COG1752	Esterase of the alpha-beta hydrolase superfamily
KU039_03305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KU039_03310	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KU039_03340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU039_03350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU039_03355	COG1077	Cell shape determining protein MreB Mrl
KU039_03360	COG1792	Involved in formation and maintenance of cell shape
KU039_03365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KU039_03370	COG0424	maF-like protein
KU039_03375	COG1530	ribonuclease E activity
KU039_03385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU039_03395	COG0560	Phosphoserine phosphatase
KU039_03405	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU039_03430	COG2207	Transcriptional regulator
KU039_03450	COG1113	amino acid transport
KU039_03455	COG2828	Protein conserved in bacteria
KU039_03460	COG0142	geranyltranstransferase activity
KU039_03465	COG2315	Protein conserved in bacteria
KU039_03480	COG1752	Esterase of the alpha-beta hydrolase superfamily
KU039_03500	COG2194	sulfuric ester hydrolase activity
KU039_03505	COG0745	RESPONSE REGULATOR receiver
KU039_03510	COG0642	Histidine kinase
KU039_03520	COG0004	ammonium transporteR
KU039_03525	COG0583	DNA-binding transcription factor activity
KU039_03545	COG0525	valine-tRNA ligase activity
KU039_03555	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_03565	COG0393	Putative heavy-metal-binding
KU039_03570	COG0393	Putative heavy-metal-binding
KU039_03575	COG1538	Outer membrane efflux protein
KU039_03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU039_03590	COG0671	phosphoesterase, PA-phosphatase related
KU039_03620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KU039_03635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KU039_03635	COG1648	precorrin-2 dehydrogenase activity
KU039_03640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KU039_03645	COG1733	regulation of RNA biosynthetic process
KU039_03655	COG0531	amino acid
KU039_03670	COG0321	lipoyl(octanoyl) transferase activity
KU039_03675	COG2921	Belongs to the UPF0250 family
KU039_03715	COG2009	succinate dehydrogenase
KU039_03720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KU039_03725	COG1053	succinate dehydrogenase
KU039_03730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KU039_03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU039_03775	COG2354	Protein conserved in bacteria
KU039_03780	COG2321	neutral zinc metallopeptidase
KU039_03815	COG2843	Capsule synthesis protein
KU039_03830	COG0589	response to stress
KU039_03850	COG0505	Belongs to the CarA family
KU039_03875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU039_03880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KU039_03945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KU039_03960	COG1597	lipid kinase activity
KU039_03965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KU039_03995	COG0584	glycerophosphoryl diester phosphodiesterase
KU039_04015	COG0741	lytic transglycosylase activity
KU039_04035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KU039_04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU039_04085	COG0778	Nitroreductase
KU039_04105	COG1929	Belongs to the glycerate kinase type-1 family
KU039_04110	COG0243	molybdopterin cofactor binding
KU039_04115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KU039_04120	COG3339	Conserved Protein
KU039_04130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KU039_04145	COG1113	amino acid transport
KU039_04155	COG0019	diaminopimelate decarboxylase activity
KU039_04165	COG1280	lysine exporter protein (LysE YggA)
KU039_04170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KU039_04200	COG0463	Glycosyl transferase, family 2
KU039_04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU039_04255	COG4591	ABC-type transport system involved in lipoprotein release permease component
KU039_04260	COG1136	(ABC) transporter
KU039_04265	COG0658	competence protein
KU039_04265	COG2333	competence protein COMEC
KU039_04275	COG0616	signal peptide processing
KU039_04275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KU039_04280	COG0596	Alpha beta hydrolase
KU039_04285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KU039_04295	COG0628	permease
KU039_04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU039_04350	COG0823	Involved in the tonB-independent uptake of proteins
KU039_04370	COG0824	Thioesterase
KU039_04375	COG1473	amidohydrolase
KU039_04395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KU039_04395	COG0047	phosphoribosylformylglycinamidine synthase activity
KU039_04400	COG2814	Major facilitator Superfamily
KU039_04410	COG1024	Enoyl-CoA hydratase
KU039_04415	COG1051	belongs to the nudix hydrolase family
KU039_04415	COG1056	cytidyltransferase-related domain
KU039_04425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KU039_04440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KU039_04455	COG4625	pathogenesis
KU039_04460	COG0583	DNA-binding transcription factor activity
KU039_04465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KU039_04470	COG4208	sulfate ABC transporter
KU039_04475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KU039_04485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KU039_04490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KU039_04495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KU039_04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KU039_04530	COG0681	Belongs to the peptidase S26 family
KU039_04545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KU039_04555	COG1381	Involved in DNA repair and RecF pathway recombination
KU039_04560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KU039_04570	COG4221	oxidoreductase activity
KU039_04600	COG0436	Aminotransferase
KU039_04620	COG0556	nucleotide-excision repair
KU039_04675	COG2070	2-Nitropropane dioxygenase
KU039_04705	COG1215	transferase activity, transferring glycosyl groups
KU039_04720	COG0415	Belongs to the DNA photolyase family
KU039_04730	COG1252	NADH dehydrogenase
KU039_04735	COG1686	Belongs to the peptidase S11 family
KU039_04750	COG1187	pseudouridine synthase activity
KU039_04775	COG0477	Major facilitator Superfamily
KU039_04780	COG0583	DNA-binding transcription factor activity
KU039_04785	COG1823	symporter activity
KU039_04795	COG0612	Peptidase, M16
KU039_04820	COG0352	thiamine-phosphate diphosphorylase activity
KU039_04855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU039_04870	COG1309	transcriptional regulator
KU039_04880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KU039_04885	COG0076	glutamate decarboxylase activity
KU039_04895	COG1522	sequence-specific DNA binding
KU039_04900	COG3961	Belongs to the TPP enzyme family
KU039_04905	COG1113	amino acid transport
KU039_04910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KU039_04915	COG0573	inorganic phosphate transmembrane transporter activity
KU039_04925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KU039_04930	COG0616	signal peptide processing
KU039_04965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KU039_04970	COG1686	Belongs to the peptidase S11 family
KU039_04995	COG0583	DNA-binding transcription factor activity
KU039_05000	COG1067	ATP-dependent peptidase activity
KU039_05045	COG1966	Carbon starvation protein
KU039_05050	COG2879	small protein
KU039_05080	COG2508	Transcriptional regulator
KU039_05080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KU039_05100	COG1113	amino acid transport
KU039_05105	COG0583	DNA-binding transcription factor activity
KU039_05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU039_05135	COG1012	belongs to the aldehyde dehydrogenase family
KU039_05140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU039_05145	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KU039_05145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU039_05180	COG2814	Major facilitator Superfamily
KU039_05185	COG4948	Mandelate Racemase Muconate Lactonizing
KU039_05195	COG1309	transcriptional regulator
KU039_05215	COG1741	Belongs to the pirin family
KU039_05225	COG2964	Protein conserved in bacteria
KU039_05240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU039_05245	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KU039_05250	COG4605	iron ion homeostasis
KU039_05255	COG4604	ABC transporter, ATP-binding protein
KU039_05260	COG4607	ABC-type enterochelin transport system periplasmic component
KU039_05265	COG4774	siderophore transport
KU039_05275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU039_05280	COG1021	2,3-dihydroxybenzoate-AMP ligase
KU039_05285	COG1535	isochorismatase
KU039_05285	COG3433	isochorismatase activity
KU039_05300	COG1132	(ABC) transporter
KU039_05305	COG1132	(ABC) transporter
KU039_05310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KU039_05320	COG1169	isochorismate synthase
KU039_05335	COG3739	integral membrane protein
KU039_05360	COG0302	gtp cyclohydrolase
KU039_05370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KU039_05400	COG0308	aminopeptidase N
KU039_05405	COG0512	Glutamine amidotransferase of anthranilate synthase
KU039_05420	COG0174	glutamine synthetase
KU039_05430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KU039_05465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KU039_05470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KU039_05475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KU039_05495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU039_05500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KU039_05505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KU039_05520	COG1960	acyl-CoA dehydrogenase activity
KU039_05525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU039_05530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU039_05540	COG2223	nitrite transmembrane transporter activity
KU039_05550	COG0024	Methionine aminopeptidase
KU039_05555	COG0052	Belongs to the universal ribosomal protein uS2 family
KU039_05570	COG2207	Transcriptional regulator
KU039_05595	COG2951	lytic endotransglycosylase activity
KU039_05600	COG0772	Belongs to the SEDS family
KU039_05615	COG0842	Transport permease protein
KU039_05620	COG1131	(ABC) transporter
KU039_05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU039_05680	COG4215	(ABC) transporter
KU039_05685	COG4160	amino acid transport
KU039_05690	COG4598	ABC transporter
KU039_05700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU039_05705	COG0826	peptidase U32
KU039_05710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU039_05725	COG1720	tRNA m6t6A37 methyltransferase activity
KU039_05735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KU039_05750	COG0642	Histidine kinase
KU039_05760	COG0494	nUDIX hydrolase
KU039_05770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KU039_05775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KU039_05780	COG3139	Protein of unknown function (DUF1315)
KU039_05785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KU039_05790	COG1301	dicarboxylic acid transport
KU039_05795	COG1960	acyl-CoA dehydrogenase activity
KU039_05800	COG2819	hydrolase of the alpha beta superfamily
KU039_05810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KU039_05820	COG2195	Cleaves the N-terminal amino acid of tripeptides
KU039_05825	COG1234	tRNA 3'-trailer cleavage
KU039_05855	COG2363	Small membrane protein
KU039_05875	COG0513	Belongs to the DEAD box helicase family
KU039_05885	COG0778	Nitroreductase
KU039_06230	COG1286	toxin biosynthetic process
KU039_06255	COG4783	chaperone-mediated protein folding
KU039_06260	COG1610	YqeY-like protein
KU039_06345	COG1301	dicarboxylic acid transport
KU039_06355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU039_06360	COG2011	ABC-type metal ion transport system permease component
KU039_06365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KU039_06370	COG1464	Belongs to the NlpA lipoprotein family
KU039_06375	COG0151	Belongs to the GarS family
KU039_06380	COG0138	bifunctional purine biosynthesis protein purh
KU039_06385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KU039_06415	COG2308	Evidence 4 Homologs of previously reported genes of
KU039_06425	COG1305	Transglutaminase-like
KU039_06435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KU039_06440	COG0305	Participates in initiation and elongation during chromosome replication
KU039_06465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KU039_06475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KU039_06480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KU039_06505	COG0726	polysaccharide deacetylase
KU039_06505	COG1649	PFAM Uncharacterised BCR, COG1649
KU039_06510	COG1215	transferase activity, transferring glycosyl groups
KU039_06515	COG3658	cytochrome
KU039_06525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU039_06540	COG0583	DNA-binding transcription factor activity
KU039_06560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU039_06565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU039_06580	COG1960	acyl-CoA dehydrogenase activity
KU039_06585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU039_06590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU039_06615	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KU039_06620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KU039_06630	COG2205	protein histidine kinase activity
KU039_06635	COG0745	RESPONSE REGULATOR receiver
KU039_06640	COG0174	glutamine synthetase
KU039_06660	COG0729	surface antigen
KU039_06685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU039_06690	COG2814	Major facilitator Superfamily
KU039_06705	COG0583	DNA-binding transcription factor activity
KU039_06720	COG1187	pseudouridine synthase activity
KU039_06740	COG0802	atpase or kinase
KU039_06745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KU039_06755	COG1923	regulation of RNA biosynthetic process
KU039_06760	COG0697	spore germination
KU039_06775	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU039_06785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU039_06790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU039_06790	COG0519	Catalyzes the synthesis of GMP from XMP
KU039_06795	COG4302	ethanolamine ammonia-lyase activity
KU039_06800	COG4303	Ethanolamine ammonia lyase large subunit
KU039_06805	COG0531	amino acid
KU039_06825	COG1454	alcohol dehydrogenase
KU039_06830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU039_06840	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KU039_06860	COG0308	aminopeptidase N
KU039_06870	COG4221	oxidoreductase activity
KU039_06880	COG1605	Chorismate mutase
KU039_06895	COG1309	transcriptional regulator
KU039_06905	COG0668	transmembrane transport
KU039_06940	COG4773	Receptor
KU039_06960	COG0488	(ABC) transporter
KU039_06965	COG0589	response to stress
KU039_06990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KU039_07000	COG3135	benzoate transporter
KU039_07005	COG1522	sequence-specific DNA binding
KU039_07015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KU039_07020	COG0583	DNA-binding transcription factor activity
KU039_07030	COG0183	Belongs to the thiolase family
KU039_07040	COG2030	dehydratase
KU039_07045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KU039_07060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KU039_07075	COG0824	Thioesterase
KU039_07080	COG1454	alcohol dehydrogenase
KU039_07090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KU039_07110	COG0069	glutamate synthase activity
KU039_07305	COG5410	chromosome segregation
KU039_07430	COG0739	heme binding
KU039_07495	COG2814	Major facilitator Superfamily
KU039_07510	COG0511	ligase activity, forming carbon-carbon bonds
KU039_07530	COG1116	anion transmembrane transporter activity
KU039_07530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU039_07535	COG0745	RESPONSE REGULATOR receiver
KU039_07545	COG2146	nitrite reductase [NAD(P)H] activity
KU039_07545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU039_07550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU039_07555	COG0243	molybdopterin cofactor binding
KU039_07565	COG0243	molybdopterin cofactor binding
KU039_07570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KU039_07585	COG0521	Mo-molybdopterin cofactor biosynthetic process
KU039_07585	COG0315	cyclic pyranopterin monophosphate synthase activity
KU039_07590	COG0303	'Molybdopterin
KU039_07600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU039_07605	COG0697	spore germination
KU039_07625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KU039_07630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU039_07695	COG2204	response regulator
KU039_07700	COG3852	Histidine kinase
KU039_07720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KU039_07725	COG0575	Belongs to the CDS family
KU039_07760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU039_07775	COG2137	regulation of response to DNA damage stimulus
KU039_07785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KU039_07790	COG1011	Hydrolase
KU039_07815	COG1522	sequence-specific DNA binding
KU039_07825	COG1113	amino acid transport
KU039_07840	COG0659	secondary active sulfate transmembrane transporter activity
KU039_07845	COG2135	peptidase activity
KU039_07865	COG3300	MHYT domain
KU039_07865	COG5001	Diguanylate cyclase
KU039_07885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KU039_07885	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KU039_07885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KU039_07890	COG1105	Belongs to the carbohydrate kinase PfkB family
KU039_07895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KU039_07895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KU039_07925	COG0024	Methionine aminopeptidase
KU039_07930	COG0583	DNA-binding transcription factor activity
KU039_07940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KU039_07945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KU039_07950	COG0516	GMP reductase activity
KU039_07950	COG0517	IMP dehydrogenase activity
KU039_07975	COG0552	protein localization to endoplasmic reticulum
KU039_07985	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KU039_08000	COG4890	Cyd operon protein YbgT
KU039_08005	COG1294	oxidase, subunit
KU039_08020	COG1585	Membrane protein implicated in regulation of membrane protease activity
KU039_08030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KU039_08035	COG4774	siderophore transport
KU039_08050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KU039_08055	COG0569	domain protein
KU039_08060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KU039_08090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KU039_08095	COG0542	response to heat
KU039_08120	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU039_08120	COG1902	pentaerythritol trinitrate reductase activity
KU039_08165	COG2323	membrane
KU039_08170	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KU039_08180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU039_08185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU039_08190	COG0183	Belongs to the thiolase family
KU039_08195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KU039_08200	COG0596	Alpha beta hydrolase
KU039_08205	COG2271	Major facilitator Superfamily
KU039_08210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KU039_08215	COG3485	protocatechuate 3,4-dioxygenase
KU039_08220	COG3485	protocatechuate 3,4-dioxygenase
KU039_08225	COG0710	3-dehydroquinate dehydratase activity
KU039_08230	COG3420	alginic acid biosynthetic process
KU039_08235	COG3659	wide pore channel activity
KU039_08240	COG4993	Dehydrogenase
KU039_08250	COG2391	methyltransferase activity
KU039_08265	COG1414	Transcriptional regulator
KU039_08270	COG0583	DNA-binding transcription factor activity
KU039_08275	COG1960	acyl-CoA dehydrogenase activity
KU039_08300	COG2814	Major facilitator Superfamily
KU039_08310	COG0154	amidase activity
KU039_08330	COG4638	Rieske (2fe-2S)
KU039_08340	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_08350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU039_08360	COG3733	amine oxidase
KU039_08370	COG1012	belongs to the aldehyde dehydrogenase family
KU039_08380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU039_08385	COG0183	Belongs to the thiolase family
KU039_08390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU039_08395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU039_08405	COG4829	muconolactone delta-isomerase
KU039_08410	COG4948	Mandelate Racemase Muconate Lactonizing
KU039_08415	COG0583	DNA-binding transcription factor activity
KU039_08425	COG2186	Transcriptional regulator
KU039_08445	COG1012	belongs to the aldehyde dehydrogenase family
KU039_08465	COG1960	acyl-CoA dehydrogenase activity
KU039_08470	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_08475	COG3829	transcription factor binding
KU039_08485	COG3162	membrane
KU039_08510	COG1012	belongs to the aldehyde dehydrogenase family
KU039_08525	COG0753	catalase activity
KU039_08545	COG1846	Transcriptional regulator
KU039_08550	COG1902	pentaerythritol trinitrate reductase activity
KU039_08550	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU039_08560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KU039_08590	COG1309	transcriptional regulator
KU039_08600	COG1335	isochorismatase
KU039_08605	COG0583	DNA-binding transcription factor activity
KU039_08615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU039_08615	COG0475	glutathione-regulated potassium exporter activity
KU039_08625	COG1473	amidohydrolase
KU039_08635	COG2831	hemolysin activation secretion protein
KU039_08640	COG3210	domain, Protein
KU039_08670	COG2188	Transcriptional regulator
KU039_08685	COG0583	DNA-binding transcription factor activity
KU039_08715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KU039_08735	COG1566	PFAM secretion protein HlyD family protein
KU039_08750	COG1012	belongs to the aldehyde dehydrogenase family
KU039_08755	COG0129	dihydroxy-acid dehydratase activity
KU039_08765	COG0583	DNA-binding transcription factor activity
KU039_08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KU039_08780	COG2084	Dehydrogenase
KU039_08785	COG2207	Transcriptional regulator
KU039_08800	COG1064	alcohol dehydrogenase
KU039_08810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KU039_08815	COG1120	ATPase activity
KU039_08835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KU039_08950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KU039_09000	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_09015	COG2207	Transcriptional regulator
KU039_09025	COG2205	protein histidine kinase activity
KU039_09030	COG0745	RESPONSE REGULATOR receiver
KU039_09035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU039_09040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU039_09045	COG1538	Outer membrane efflux protein
KU039_09055	COG2072	flavoprotein involved in K transport
KU039_09075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU039_09095	COG3539	Fimbrial protein
KU039_09125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KU039_09135	COG0753	catalase activity
KU039_09150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU039_09215	COG3433	isochorismatase activity
KU039_09215	COG1535	isochorismatase
KU039_09220	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_09225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KU039_09230	COG4149	molybdate abc transporter
KU039_09235	COG0725	ABC transporter, periplasmic molybdate-binding protein
KU039_09245	COG4638	Rieske (2fe-2S)
KU039_09250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KU039_09255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU039_09255	COG0543	2 iron, 2 sulfur cluster binding
KU039_09280	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_09295	COG2207	Transcriptional regulator
KU039_09305	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_09310	COG2610	gluconate transmembrane transporter activity
KU039_09320	COG0583	DNA-binding transcription factor activity
KU039_09330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU039_09335	COG2031	fatty acid transporter
KU039_09340	COG0183	Belongs to the thiolase family
KU039_09345	COG0583	DNA-binding transcription factor activity
KU039_09350	COG0583	DNA-binding transcription factor activity
KU039_09365	COG1027	Aspartate ammonia-lyase
KU039_09375	COG0477	Major facilitator Superfamily
KU039_09395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU039_09400	COG4521	taurine ABC transporter
KU039_09415	COG2188	Transcriptional regulator
KU039_09425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KU039_09430	COG1733	regulation of RNA biosynthetic process
KU039_09435	COG3708	Transcriptional regulator
KU039_09435	COG2207	Transcriptional regulator
KU039_09450	COG0730	response to heat
KU039_09460	COG3453	Protein conserved in bacteria
KU039_09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU039_09470	COG3781	membrane
KU039_09475	COG1063	alcohol dehydrogenase
KU039_09485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU039_09490	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU039_09495	COG0022	dehydrogenase e1 component
KU039_09500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KU039_09505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU039_09520	COG3706	GGDEF domain
KU039_09535	COG0133	tryptophan synthase activity
KU039_09545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU039_09580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KU039_09605	COG2226	methyltransferase
KU039_09660	COG0842	Transport permease protein
KU039_09665	COG0842	Transport permease protein
KU039_09670	COG1131	(ABC) transporter
KU039_09685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU039_09690	COG4773	Receptor
KU039_09710	COG0730	response to heat
KU039_09715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KU039_09735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KU039_09750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KU039_09790	COG4264	IucA IucC family
KU039_09795	COG4264	IucA IucC family
KU039_09815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KU039_09830	COG1960	acyl-CoA dehydrogenase activity
KU039_09835	COG1960	acyl-CoA dehydrogenase activity
KU039_09840	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU039_09845	COG2207	Transcriptional regulator
KU039_09850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU039_09855	COG0776	regulation of translation
KU039_09880	COG0822	iron-sulfur transferase activity
KU039_09885	COG0316	Belongs to the HesB IscA family
KU039_09915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KU039_09935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KU039_09940	COG0702	epimerase
KU039_09975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KU039_09985	COG0339	signal peptide processing
KU039_10035	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KU039_10155	COG5484	DNA packaging
KU039_10155	COG3728	DNA packaging
KU039_10250	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KU039_10280	COG0776	regulation of translation
KU039_10345	COG0084	hydrolase, TatD family'
KU039_10365	COG1663	tetraacyldisaccharide 4'-kinase activity
KU039_10370	COG1132	(ABC) transporter
KU039_10380	COG0811	peptide transport
KU039_10385	COG1475	DNA binding
KU039_10390	COG1192	Involved in chromosome partitioning
KU039_10400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KU039_10415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU039_10420	COG0191	fructose-bisphosphate aldolase activity
KU039_10440	COG0424	maF-like protein
KU039_10445	COG2850	peptidyl-arginine hydroxylation
KU039_10455	COG0640	Transcriptional regulator
KU039_10465	COG3619	membrane
KU039_10470	COG3122	Protein conserved in bacteria
KU039_10475	COG1132	(ABC) transporter
KU039_10495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KU039_10500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU039_10510	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KU039_10510	COG0506	proline dehydrogenase activity
KU039_10510	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KU039_10515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KU039_10530	COG3698	Phosphodiester glycosidase
KU039_10540	COG2353	YceI-like domain
KU039_10550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KU039_10595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KU039_10595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KU039_10620	COG3539	Fimbrial protein
KU039_10625	COG3121	Chaperone
KU039_10650	COG0697	spore germination
KU039_10660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KU039_10670	COG0583	DNA-binding transcription factor activity
KU039_10690	COG1309	transcriptional regulator
KU039_10705	COG1522	sequence-specific DNA binding
KU039_10720	COG1126	abc transporter atp-binding protein
KU039_10725	COG0765	amino acid transport
KU039_10730	COG0765	amino acid transport
KU039_10760	COG1464	Belongs to the NlpA lipoprotein family
KU039_10780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KU039_10785	COG2011	ABC-type metal ion transport system permease component
KU039_10790	COG0012	GTP binding
KU039_10815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KU039_10855	COG0386	Belongs to the glutathione peroxidase family
KU039_10865	COG0436	Aminotransferase
KU039_10905	COG3634	alkyl hydroperoxide reductase activity
KU039_10920	COG0583	DNA-binding transcription factor activity
KU039_10925	COG0798	PFAM Bile acid sodium symporter
KU039_10930	COG0640	Transcriptional regulator
KU039_10945	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KU039_10955	COG0583	DNA-binding transcription factor activity
KU039_10965	COG1953	Uracil, thiamine, allantoin
KU039_10975	COG2175	clavaminate synthase activity
KU039_10980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU039_10985	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KU039_10990	COG4521	taurine ABC transporter
KU039_11000	COG0477	Major facilitator Superfamily
KU039_11020	COG1271	oxidase subunit
KU039_11025	COG1294	oxidase, subunit
KU039_11035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU039_11055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KU039_11075	COG3052	prosthetic group binding
KU039_11080	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KU039_11090	COG2814	Major facilitator Superfamily
KU039_11110	COG1346	cytolysis
KU039_11120	COG0583	DNA-binding transcription factor activity
KU039_11125	COG0625	glutathione transferase activity
KU039_11130	COG0625	glutathione transferase activity
KU039_11135	COG0583	DNA-binding transcription factor activity
KU039_11150	COG1045	serine acetyltransferase
KU039_11155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU039_11160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KU039_11170	COG1280	lysine exporter protein (LysE YggA)
KU039_11185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU039_11190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU039_11195	COG1126	abc transporter atp-binding protein
KU039_11200	COG0765	amino acid transport
KU039_11205	COG0765	amino acid transport
KU039_11225	COG0784	Response regulator, receiver
KU039_11225	COG2205	protein histidine kinase activity
KU039_11245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KU039_11265	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_11315	COG0583	DNA-binding transcription factor activity
KU039_11335	COG0318	PFAM AMP-dependent synthetase and ligase
KU039_11340	COG1309	transcriptional regulator
KU039_11345	COG1960	acyl-CoA dehydrogenase activity
KU039_11350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KU039_11355	COG1024	Enoyl-CoA hydratase
KU039_11360	COG4770	biotin carboxylase activity
KU039_11370	COG0583	DNA-binding transcription factor activity
KU039_11385	COG1960	acyl-CoA dehydrogenase activity
KU039_11395	COG2814	Major facilitator Superfamily
KU039_11405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU039_11410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU039_11415	COG2814	Major facilitator Superfamily
KU039_11420	COG1960	acyl-CoA dehydrogenase activity
KU039_11425	COG1024	Enoyl-CoA hydratase
KU039_11430	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_11435	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU039_11440	COG0183	Belongs to the thiolase family
KU039_11450	COG2814	Major facilitator Superfamily
KU039_11460	COG1024	Enoyl-CoA hydratase
KU039_11475	COG1960	acyl-CoA dehydrogenase activity
KU039_11480	COG2814	Major facilitator Superfamily
KU039_11485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KU039_11490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KU039_11505	COG3842	ATPase activity
KU039_11510	COG1840	ABC-type Fe3 transport system, periplasmic component
KU039_11520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU039_11525	COG1414	Transcriptional regulator
KU039_11535	COG0583	DNA-binding transcription factor activity
KU039_11540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KU039_11545	COG1012	belongs to the aldehyde dehydrogenase family
KU039_11555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KU039_11565	COG1012	belongs to the aldehyde dehydrogenase family
KU039_11570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU039_11575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU039_11580	COG2267	carboxylic ester hydrolase activity
KU039_11600	COG3038	cytochrome b561
KU039_11605	COG0753	catalase activity
KU039_11640	COG2050	protein possibly involved in aromatic compounds catabolism
KU039_11650	COG3327	negative regulation of DNA-templated transcription, initiation
KU039_11655	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KU039_11660	COG0183	Belongs to the thiolase family
KU039_11665	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU039_11670	COG1024	Enoyl-CoA hydratase
KU039_11675	COG1024	Enoyl-CoA hydratase
KU039_11680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU039_11685	COG2151	metal-sulfur cluster biosynthetic enzyme
KU039_11690	COG3396	Phenylacetate-CoA oxygenase
KU039_11695	COG3460	Phenylacetate-CoA oxygenase
KU039_11700	COG3396	Phenylacetate-CoA oxygenase
KU039_11705	COG1012	belongs to the aldehyde dehydrogenase family
KU039_11705	COG2030	dehydratase
KU039_11710	COG1760	l-serine dehydratase
KU039_11715	COG0531	amino acid
KU039_11720	COG1012	belongs to the aldehyde dehydrogenase family
KU039_11735	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU039_11745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU039_11765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU039_11775	COG0789	Transcriptional regulator
KU039_11790	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KU039_11805	COG2807	transmembrane transport
KU039_11810	COG0590	tRNA wobble adenosine to inosine editing
KU039_11925	COG1116	anion transmembrane transporter activity
KU039_11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU039_11940	COG0864	Transcriptional regulator
KU039_11960	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU039_11965	COG0439	Biotin carboxylase
KU039_11980	COG1063	alcohol dehydrogenase
KU039_11990	COG1309	transcriptional regulator
KU039_12010	COG0038	chloride channel
KU039_12015	COG4770	biotin carboxylase activity
KU039_12035	COG1914	H( )-stimulated, divalent metal cation uptake system
KU039_12040	COG0583	DNA-binding transcription factor activity
KU039_12090	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU039_12110	COG2814	Major facilitator Superfamily
KU039_12120	COG1560	Kdo2-lipid A biosynthetic process
KU039_12130	COG5006	permease, DMT superfamily
KU039_12135	COG1522	sequence-specific DNA binding
KU039_12150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KU039_12160	COG4122	O-methyltransferase activity
KU039_12190	COG1538	Outer membrane efflux protein
KU039_12195	COG1137	ATPase activity
KU039_12200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KU039_12210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KU039_12215	COG0517	IMP dehydrogenase activity
KU039_12215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KU039_12260	COG2814	Major facilitator Superfamily
KU039_12295	COG1278	Cold shock
KU039_12300	COG1280	lysine exporter protein (LysE YggA)
KU039_12330	COG1570	exodeoxyribonuclease VII activity
KU039_12380	COG0583	DNA-binding transcription factor activity
KU039_12385	COG4638	Rieske (2fe-2S)
KU039_12390	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KU039_12395	COG0543	2 iron, 2 sulfur cluster binding
KU039_12395	COG0633	Ferredoxin
KU039_12400	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_12405	COG3135	benzoate transporter
KU039_12410	COG2814	Major facilitator Superfamily
KU039_12425	COG1643	Atp-dependent helicase
KU039_12430	COG0450	alkyl hydroperoxide reductase
KU039_12440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KU039_12450	COG3634	alkyl hydroperoxide reductase activity
KU039_12470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KU039_12475	COG0625	glutathione transferase activity
KU039_12485	COG2885	chlorophyll binding
KU039_12520	COG0542	response to heat
KU039_12535	COG1765	OsmC-like protein
KU039_12555	COG0667	Aldo Keto reductase
KU039_12570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KU039_12580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KU039_12590	COG0527	aspartate kinase activity
KU039_12600	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KU039_12610	COG3038	cytochrome b561
KU039_12615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KU039_12620	COG2252	PERMEase
KU039_12630	COG2072	flavoprotein involved in K transport
KU039_12645	COG1741	Belongs to the pirin family
KU039_12660	COG1012	belongs to the aldehyde dehydrogenase family
KU039_12680	COG0531	amino acid
KU039_12690	COG1113	amino acid transport
KU039_12730	COG3209	COG3209 Rhs family protein
KU039_12760	COG4269	membrane
KU039_12775	COG1902	pentaerythritol trinitrate reductase activity
KU039_12775	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU039_12785	COG3706	GGDEF domain
KU039_12785	COG4251	negative regulation of phosphorylation
KU039_12785	COG2203	Gaf domain
KU039_12785	COG5001	Diguanylate cyclase
KU039_12795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU039_12815	COG4172	Belongs to the ABC transporter superfamily
KU039_12820	COG4239	(ABC) transporter, permease
KU039_12825	COG4174	ABC transporter (Permease)
KU039_12835	COG1388	LysM domain
KU039_12835	COG0741	lytic transglycosylase activity
KU039_12835	COG0741	lytic transglycosylase activity
KU039_12835	COG1388	LysM domain
KU039_12840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU039_12880	COG0583	DNA-binding transcription factor activity
KU039_12885	COG1279	arginine transmembrane transporter activity
KU039_12905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU039_12910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU039_12915	COG0006	proline dipeptidase activity
KU039_12955	COG2194	sulfuric ester hydrolase activity
KU039_13000	COG0739	heme binding
KU039_13325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KU039_13350	COG3384	dioxygenase
KU039_13360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU039_13365	COG2878	Part of a membrane complex involved in electron transport
KU039_13370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KU039_13395	COG0768	penicillin binding
KU039_13400	COG0742	ribosomal rna small subunit methyltransferase
KU039_13415	COG0830	nickel cation binding
KU039_13460	COG1253	flavin adenine dinucleotide binding
KU039_13465	COG2851	Citrate transporter
KU039_13515	COG1773	rubredoxin
KU039_13520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU039_13530	COG0583	DNA-binding transcription factor activity
KU039_13555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KU039_13560	COG4181	ATPase activity
KU039_13605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KU039_13625	COG0306	phosphate transporter
KU039_13635	COG3958	Transketolase
KU039_13640	COG3959	Transketolase, thiamine diphosphate binding domain
KU039_13645	COG2271	Major facilitator Superfamily
KU039_13650	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_13655	COG0583	DNA-binding transcription factor activity
KU039_13670	COG2223	nitrite transmembrane transporter activity
KU039_13675	COG2207	Transcriptional regulator
KU039_13680	COG2066	Belongs to the glutaminase family
KU039_13685	COG0242	peptide deformylase activity
KU039_13690	COG0477	Major facilitator Superfamily
KU039_13700	COG0028	Belongs to the TPP enzyme family
KU039_13715	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_13720	COG2267	carboxylic ester hydrolase activity
KU039_13730	COG2271	Major facilitator Superfamily
KU039_13735	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU039_13745	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_13765	COG1414	Transcriptional regulator
KU039_13780	COG1024	Enoyl-CoA hydratase
KU039_13790	COG1215	transferase activity, transferring glycosyl groups
KU039_13795	COG0726	polysaccharide deacetylase
KU039_13795	COG1649	PFAM Uncharacterised BCR, COG1649
KU039_13805	COG4681	YaeQ
KU039_13815	COG0523	cobalamin synthesis protein
KU039_13825	COG1607	acyl-coa hydrolase
KU039_13835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU039_13840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU039_13845	COG1309	transcriptional regulator
KU039_13870	COG2040	homocysteine
KU039_13875	COG0531	amino acid
KU039_13930	COG1595	DNA-templated transcription, initiation
KU039_13940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU039_13945	COG0477	Major facilitator Superfamily
KU039_13965	COG0084	hydrolase, TatD family'
KU039_14000	COG0629	single-stranded DNA binding
KU039_14055	COG0582	viral genome integration into host DNA
KU039_14085	COG1061	Type III restriction enzyme res subunit
KU039_14095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KU039_14100	COG1192	Involved in chromosome partitioning
KU039_14195	COG0592	DNA-directed DNA polymerase activity
KU039_14235	COG2026	Addiction module toxin, RelE StbE family
KU039_14395	COG3755	Protein conserved in bacteria
KU039_14440	COG1484	DNA-dependent DNA replication
KU039_14530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU039_14600	COG0405	Gamma-glutamyltransferase
KU039_14605	COG2814	Major facilitator Superfamily
KU039_14615	COG2050	protein possibly involved in aromatic compounds catabolism
KU039_14630	COG1090	epimerase
KU039_14650	COG0420	3'-5' exonuclease activity
KU039_14675	COG0735	belongs to the Fur family
KU039_14680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KU039_14700	COG0121	glutamine amidotransferase
KU039_14715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU039_14725	COG0210	DNA helicase
KU039_14730	COG2885	chlorophyll binding
KU039_14735	COG0204	Acyl-transferase
KU039_14750	COG2894	cell division
KU039_14770	COG1280	lysine exporter protein (LysE YggA)
KU039_14775	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KU039_14775	COG1674	ftsk spoiiie
KU039_14780	COG0492	ferredoxin-NADP+ reductase activity
KU039_14785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KU039_14795	COG0456	acetyltransferase
KU039_14840	COG1981	membrane
KU039_14855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KU039_14855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU039_14875	COG1012	belongs to the aldehyde dehydrogenase family
KU039_14885	COG0657	acetylesterase activity
KU039_14895	COG0473	3-isopropylmalate dehydrogenase activity
KU039_14900	COG0583	DNA-binding transcription factor activity
KU039_14920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU039_14945	COG0564	pseudouridine synthase activity
KU039_14955	COG0358	DNA primase activity
KU039_14970	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KU039_15000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KU039_15030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KU039_15040	COG0352	thiamine-phosphate diphosphorylase activity
KU039_15040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KU039_15040	COG0351	phosphomethylpyrimidine kinase
KU039_15045	COG1652	LysM domain
KU039_15070	COG1399	metal-binding, possibly nucleic acid-binding protein
KU039_15075	COG3101	peptidyl-lysine hydroxylation
KU039_15080	COG0009	L-threonylcarbamoyladenylate synthase
KU039_15085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KU039_15090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KU039_15105	COG4106	trans-aconitate 2-methyltransferase activity
KU039_15120	COG0596	Alpha beta hydrolase
KU039_15120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU039_15120	COG2226	methyltransferase
KU039_15125	COG1877	trehalose-phosphatase activity
KU039_15130	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KU039_15135	COG2223	nitrite transmembrane transporter activity
KU039_15155	COG1196	nuclear chromosome segregation
KU039_15165	COG0730	response to heat
KU039_15180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KU039_15190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU039_15240	COG0489	protein tyrosine kinase activity
KU039_15250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU039_15250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU039_15280	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KU039_15285	COG2081	HI0933 family
KU039_15295	COG0668	transmembrane transport
KU039_15315	COG0583	DNA-binding transcription factor activity
KU039_15335	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU039_15340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KU039_15370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KU039_15410	COG0745	RESPONSE REGULATOR receiver
KU039_15430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KU039_15440	COG2205	protein histidine kinase activity
KU039_15510	COG4993	Dehydrogenase
KU039_15535	COG0384	phenazine biosynthesis protein PhzF
KU039_15555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU039_15570	COG0583	DNA-binding transcription factor activity
KU039_15600	COG0583	DNA-binding transcription factor activity
KU039_15615	COG0583	DNA-binding transcription factor activity
KU039_15620	COG1053	succinate dehydrogenase
KU039_15630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KU039_15635	COG2814	Major facilitator Superfamily
KU039_15640	COG1960	acyl-CoA dehydrogenase activity
KU039_15645	COG0583	DNA-binding transcription factor activity
KU039_15650	COG1063	alcohol dehydrogenase
KU039_15680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KU039_15685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KU039_15690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU039_15705	COG3667	copper resistance
KU039_15710	COG2132	Multicopper oxidase
KU039_15720	COG0561	phosphatase activity
KU039_15725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KU039_15750	COG1214	PFAM Peptidase M22, glycoprotease
KU039_15800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KU039_15810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KU039_15815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KU039_15820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KU039_15880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU039_15890	COG1846	Transcriptional regulator
KU039_15895	COG1764	response to oxidative stress
KU039_15935	COG0037	tRNA processing
KU039_15945	COG0248	Ppx GppA phosphatase
KU039_15975	COG0072	phenylalanine-tRNA ligase activity
KU039_16015	COG1238	metal cluster binding
KU039_16020	COG0625	glutathione transferase activity
KU039_16035	COG0318	PFAM AMP-dependent synthetase and ligase
KU039_16040	COG3028	Belongs to the UPF0307 family
KU039_16045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KU039_16065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KU039_16070	COG0617	tRNA 3'-terminal CCA addition
KU039_16075	COG1555	photosystem II stabilization
KU039_16080	COG3956	TIGRFAM MazG family protein
KU039_16090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU039_16110	COG2205	protein histidine kinase activity
KU039_16110	COG0784	Response regulator, receiver
KU039_16110	COG5002	protein histidine kinase activity
KU039_16115	COG1024	Enoyl-CoA hydratase
KU039_16120	COG2084	Dehydrogenase
KU039_16125	COG3622	Belongs to the hyi family
KU039_16155	COG0697	spore germination
KU039_16165	COG2814	Major facilitator Superfamily
KU039_16170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU039_16180	COG0583	DNA-binding transcription factor activity
KU039_16190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KU039_16205	COG0084	hydrolase, TatD family'
KU039_16220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KU039_16250	COG0440	acetolactate synthase activity
KU039_16255	COG0028	Belongs to the TPP enzyme family
KU039_16280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU039_16285	COG1136	(ABC) transporter
KU039_16285	COG0577	efflux transmembrane transporter activity
KU039_16290	COG1538	Outer membrane efflux protein
KU039_16305	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KU039_16310	COG1162	GTPase activity
KU039_16320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KU039_16340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KU039_16345	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_16385	COG2986	histidine ammonia-lyase
KU039_16400	COG0318	PFAM AMP-dependent synthetase and ligase
KU039_16410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU039_16455	COG1426	Protein conserved in bacteria
KU039_16490	COG0793	Belongs to the peptidase S41A family
KU039_16505	COG2267	carboxylic ester hydrolase activity
KU039_16515	COG1012	belongs to the aldehyde dehydrogenase family
KU039_16520	COG3265	gluconokinase activity
KU039_16530	COG0800	Aldolase
KU039_16540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KU039_16545	COG0280	phosphate acetyltransferase
KU039_16545	COG0857	belongs to the CobB CobQ family
KU039_16550	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KU039_16550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KU039_16570	COG0740	serine-type endopeptidase activity
KU039_16580	COG4774	siderophore transport
KU039_16590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KU039_16600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU039_16600	COG2813	Specifically methylates the guanine in position
KU039_16700	COG0788	formyltetrahydrofolate deformylase activity
KU039_16725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU039_16725	COG4651	solute:proton antiporter activity
KU039_16745	COG0724	RNA recognition motif
KU039_16750	COG0210	DNA helicase
KU039_16775	COG1733	regulation of RNA biosynthetic process
KU039_16785	COG2900	Belongs to the SlyX family
KU039_16790	COG0488	(ABC) transporter
KU039_16795	COG1280	lysine exporter protein (LysE YggA)
KU039_16800	COG1560	Kdo2-lipid A biosynthetic process
KU039_16810	COG1301	dicarboxylic acid transport
KU039_16865	COG0473	3-isopropylmalate dehydrogenase activity
KU039_16930	COG0583	DNA-binding transcription factor activity
KU039_16940	COG0625	glutathione transferase activity
KU039_16945	COG2378	regulation of single-species biofilm formation
KU039_16950	COG0546	phosphoglycolate phosphatase activity
KU039_16960	COG1530	ribonuclease E activity
KU039_16965	COG0318	PFAM AMP-dependent synthetase and ligase
KU039_16980	COG0583	DNA-binding transcription factor activity
KU039_16985	COG4221	oxidoreductase activity
KU039_16990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KU039_17000	COG0534	Mate efflux family protein
KU039_17015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KU039_17055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KU039_17060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU039_17075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KU039_17085	COG0644	oxidoreductase
KU039_17085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KU039_17090	COG0425	Belongs to the sulfur carrier protein TusA family
KU039_17095	COG4535	Mg2 and Co2 transporter CorC
KU039_17105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU039_17125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KU039_17130	COG0475	glutathione-regulated potassium exporter activity
KU039_17130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU039_17135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KU039_17145	COG0484	heat shock protein binding
KU039_17150	COG0789	Transcriptional regulator
KU039_17155	COG0598	Magnesium transport protein CorA
KU039_17170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KU039_17175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU039_17180	COG1074	ATP-dependent DNA helicase activity
KU039_17185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KU039_17205	COG2226	methyltransferase
KU039_17220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU039_17225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KU039_17240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KU039_17240	COG2111	Na H antiporter
KU039_17245	COG1006	Multisubunit Na H antiporter MnhC subunit
KU039_17250	COG0651	ATP synthesis coupled electron transport
KU039_17255	COG1863	multisubunit Na H antiporter MnhE subunit
KU039_17260	COG2212	antiporter activity
KU039_17265	COG1320	monovalent cation:proton antiporter activity
KU039_17280	COG0195	Participates in both transcription termination and antitermination
KU039_17330	COG0237	dephospho-CoA kinase activity
KU039_17340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU039_17355	COG0497	DNA recombination
KU039_17365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KU039_17395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU039_17395	COG2169	Transcriptional regulator
KU039_17400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KU039_17465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KU039_17480	COG0326	Molecular chaperone. Has ATPase activity
KU039_17495	COG2056	Na+-H+ antiporter family
KU039_17500	COG0596	Alpha beta hydrolase
KU039_17595	COG0546	phosphoglycolate phosphatase activity
KU039_17600	COG1716	ATPase activity
KU039_17645	COG0181	hydroxymethylbilane synthase activity
KU039_17655	COG3275	phosphorelay sensor kinase activity
KU039_17675	COG1538	Outer membrane efflux protein
KU039_17680	COG0697	spore germination
KU039_17705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KU039_17710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KU039_17715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU039_17720	COG0772	Belongs to the SEDS family
KU039_17745	COG4974	Belongs to the 'phage' integrase family
KU039_17750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU039_17760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KU039_17770	COG2197	response regulator
KU039_17785	COG0793	Belongs to the peptidase S41A family
KU039_17790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KU039_17795	COG0795	lipopolysaccharide-transporting ATPase activity
KU039_17835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU039_17835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU039_17845	COG0004	ammonium transporteR
KU039_17850	COG0347	Belongs to the P(II) protein family
KU039_17860	COG0606	chelatase, subunit chli
KU039_17910	COG0659	secondary active sulfate transmembrane transporter activity
KU039_17915	COG0589	response to stress
KU039_17945	COG0606	chelatase, subunit chli
KU039_17950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU039_17960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU039_17975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KU039_17990	COG0318	PFAM AMP-dependent synthetase and ligase
KU039_18000	COG0477	Major facilitator Superfamily
KU039_18005	COG2860	membrane
KU039_18015	COG1253	flavin adenine dinucleotide binding
KU039_18035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KU039_18070	COG0655	NAD(P)H dehydrogenase (quinone) activity
KU039_18080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KU039_18115	COG1309	transcriptional regulator
KU039_18150	COG0758	DNA mediated transformation
KU039_18160	COG0697	spore germination
KU039_18165	COG1309	transcriptional regulator
KU039_18180	COG0386	Belongs to the glutathione peroxidase family
KU039_18245	COG1121	(ABC) transporter
KU039_18250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KU039_18255	COG1280	lysine exporter protein (LysE YggA)
KU039_18260	COG2837	iron assimilation
KU039_18270	COG0281	malic enzyme
KU039_18315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU039_18315	COG0519	Catalyzes the synthesis of GMP from XMP
KU039_18320	COG4399	Belongs to the UPF0754 family
KU039_18325	COG2259	Doxx family
KU039_18330	COG0586	Pfam SNARE associated Golgi protein
KU039_18345	COG1192	Involved in chromosome partitioning
KU039_18355	COG0271	Belongs to the BolA IbaG family
KU039_18375	COG2267	carboxylic ester hydrolase activity
KU039_18395	COG3321	synthase
KU039_18395	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KU039_18395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KU039_18395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU039_18400	COG1960	acyl-CoA dehydrogenase activity
KU039_18410	COG2197	response regulator
KU039_18420	COG3916	Acyl-homoserine-lactone synthase
KU039_18425	COG0477	Major facilitator Superfamily
KU039_18430	COG1024	Enoyl-CoA hydratase
KU039_18435	COG1024	Enoyl-CoA hydratase
KU039_18440	COG1960	acyl-CoA dehydrogenase activity
KU039_18445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU039_18465	COG1113	amino acid transport
KU039_18470	COG1113	amino acid transport
KU039_18475	COG0251	oxidation-reduction process
KU039_18515	COG0564	pseudouridine synthase activity
KU039_18575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KU039_18590	COG1802	Transcriptional regulator
KU039_18600	COG1448	Aminotransferase
KU039_18605	COG0277	FAD linked oxidase domain protein
KU039_18615	COG2186	Transcriptional regulator
KU039_18625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU039_18630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU039_18645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KU039_18650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KU039_18655	COG1216	Glycosyl transferase, family 2
KU039_18685	COG2089	acid synthase
KU039_18700	COG1083	cytidylyl-transferase
KU039_18705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KU039_18710	COG1086	Polysaccharide biosynthesis protein
KU039_18715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KU039_18720	COG1596	polysaccharide export
KU039_18745	COG0728	peptidoglycan biosynthetic process
KU039_18750	COG3023	N-Acetylmuramoyl-L-alanine amidase
KU039_18805	COG0546	phosphoglycolate phosphatase activity
KU039_18810	COG1028	Short-chain dehydrogenase reductase Sdr
KU039_18830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU039_18835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU039_18840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU039_18845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU039_18850	COG1116	anion transmembrane transporter activity
KU039_18855	COG1309	transcriptional regulator
KU039_18860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KU039_18870	COG0196	riboflavin kinase activity
KU039_18875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KU039_18885	COG1047	Peptidyl-prolyl cis-trans
KU039_18925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KU039_18930	COG0657	acetylesterase activity
KU039_18980	COG2951	lytic endotransglycosylase activity
KU039_18985	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KU039_19000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KU039_19010	COG0671	phosphoesterase, PA-phosphatase related
KU039_19015	COG0861	Integral membrane protein TerC family
KU039_19025	COG0754	glutathionylspermidine amidase activity
KU039_19035	COG0402	S-adenosylhomocysteine deaminase activity
KU039_19050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU039_19055	COG1230	cation diffusion facilitator family transporter
KU039_19070	COG0706	membrane insertase activity
KU039_19125	COG1309	transcriptional regulator
KU039_19130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KU039_19145	COG1525	nuclease
KU039_19160	COG3451	type IV secretory pathway VirB4
KU039_19170	COG0739	heme binding
KU039_19170	COG1196	nuclear chromosome segregation
KU039_19170	COG0741	lytic transglycosylase activity
KU039_19185	COG1196	nuclear chromosome segregation
KU039_19185	COG0741	lytic transglycosylase activity
KU039_19185	COG0739	heme binding
KU039_19210	COG3504	Conjugal transfer protein
KU039_19245	COG1192	Involved in chromosome partitioning
KU039_19360	COG4683	PFAM Phage derived protein Gp49-like (DUF891)