locus-tag	class	description
GWK28_00010	COG0592	DNA-directed DNA polymerase activity
GWK28_00020	COG0187	DNA topoisomerase II activity
GWK28_00030	COG0586	Pfam SNARE associated Golgi protein
GWK28_00035	COG0488	(ABC) transporter
GWK28_00060	COG0596	Alpha beta hydrolase
GWK28_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWK28_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK28_00110	COG0733	neurotransmitter:sodium symporter activity
GWK28_00145	COG0583	DNA-binding transcription factor activity
GWK28_00150	COG2233	PERMEase
GWK28_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_00200	COG2814	Major facilitator Superfamily
GWK28_00205	COG0656	L-ascorbic acid biosynthetic process
GWK28_00210	COG0583	DNA-binding transcription factor activity
GWK28_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_00230	COG1064	alcohol dehydrogenase
GWK28_00235	COG2818	Glycosylase
GWK28_00250	COG1194	a g-specific adenine glycosylase
GWK28_00270	COG2983	Belongs to the UPF0260 family
GWK28_00275	COG2133	pyrroloquinoline quinone binding
GWK28_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWK28_00285	COG2116	formate transmembrane transporter activity
GWK28_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_00310	COG1335	isochorismatase
GWK28_00315	COG0385	Bile acid
GWK28_00320	COG0534	Mate efflux family protein
GWK28_00325	COG1683	Conserved Protein
GWK28_00345	COG0625	glutathione transferase activity
GWK28_00355	COG1113	amino acid transport
GWK28_00365	COG0523	cobalamin synthesis protein
GWK28_00375	COG2188	Transcriptional regulator
GWK28_00405	COG0010	Belongs to the arginase family
GWK28_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWK28_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK28_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK28_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWK28_00530	COG0534	Mate efflux family protein
GWK28_00535	COG0436	Aminotransferase
GWK28_00540	COG2733	membrane
GWK28_00555	COG2918	glutathione biosynthetic process
GWK28_00570	COG5632	N-Acetylmuramoyl-L-alanine amidase
GWK28_00570	COG1388	LysM domain
GWK28_00570	COG3409	Peptidoglycan-binding domain 1 protein
GWK28_00620	COG3150	esterase
GWK28_00630	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_00635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GWK28_00645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_00655	COG2233	PERMEase
GWK28_00660	COG2351	hydroxyisourate hydrolase activity
GWK28_00690	COG3328	transposase activity
GWK28_00700	COG3706	GGDEF domain
GWK28_00715	COG1393	Belongs to the ArsC family
GWK28_00720	COG0708	Exodeoxyribonuclease III
GWK28_00750	COG0189	ligase activity
GWK28_00770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWK28_00780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK28_00795	COG4942	peptidase
GWK28_00805	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK28_00815	COG2119	membrane
GWK28_00820	COG4774	siderophore transport
GWK28_00825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_00825	COG0426	domain, Protein
GWK28_00850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWK28_00870	COG1902	pentaerythritol trinitrate reductase activity
GWK28_00875	COG1519	Transferase
GWK28_00880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK28_00885	COG0668	transmembrane transport
GWK28_00895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK28_00900	COG1335	isochorismatase
GWK28_00905	COG1522	sequence-specific DNA binding
GWK28_00930	COG0784	Response regulator, receiver
GWK28_00930	COG2205	protein histidine kinase activity
GWK28_00930	COG2198	Histidine kinase
GWK28_00935	COG3162	membrane
GWK28_00940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK28_00950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK28_00965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK28_00970	COG1309	transcriptional regulator
GWK28_00990	COG0351	phosphomethylpyrimidine kinase
GWK28_00990	COG0352	thiamine-phosphate diphosphorylase activity
GWK28_00990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK28_01000	COG2814	Major facilitator Superfamily
GWK28_01015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GWK28_01025	COG1113	amino acid transport
GWK28_01035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK28_01040	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_01050	COG1335	isochorismatase
GWK28_01080	COG2814	Major facilitator Superfamily
GWK28_01085	COG0583	DNA-binding transcription factor activity
GWK28_01105	COG0667	Aldo Keto reductase
GWK28_01145	COG1733	regulation of RNA biosynthetic process
GWK28_01150	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_01215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK28_01255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWK28_01285	COG0427	acetyl-CoA hydrolase
GWK28_01310	COG0659	secondary active sulfate transmembrane transporter activity
GWK28_01315	COG4221	oxidoreductase activity
GWK28_01320	COG2873	o-acetylhomoserine
GWK28_01325	COG0488	(ABC) transporter
GWK28_01390	COG0833	amino acid
GWK28_01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWK28_01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWK28_01455	COG2226	methyltransferase
GWK28_01505	COG0070	glutamate synthase
GWK28_01505	COG0069	glutamate synthase activity
GWK28_01505	COG0067	glutamate synthase
GWK28_01510	COG0493	'glutamate synthase
GWK28_01520	COG1704	LemA family
GWK28_01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWK28_01535	COG4969	Belongs to the N-Me-Phe pilin family
GWK28_01545	COG3307	-O-antigen
GWK28_01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK28_01580	COG0194	GDP metabolic process
GWK28_01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWK28_01650	COG5380	lipid catabolic process
GWK28_01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK28_01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK28_01685	COG0277	FAD linked oxidase domain protein
GWK28_01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GWK28_01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_01715	COG1289	transmembrane transporter activity
GWK28_01725	COG0628	permease
GWK28_01730	COG1192	Involved in chromosome partitioning
GWK28_01760	COG0833	amino acid
GWK28_01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK28_01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK28_01780	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_01820	COG0583	DNA-binding transcription factor activity
GWK28_01840	COG1106	Psort location Cytoplasmic, score
GWK28_01875	COG0517	IMP dehydrogenase activity
GWK28_01880	COG1983	PspC domain protein
GWK28_01890	COG1960	acyl-CoA dehydrogenase activity
GWK28_01905	COG0408	coproporphyrinogen oxidase activity
GWK28_01925	COG0513	Belongs to the DEAD box helicase family
GWK28_01935	COG1127	ABC transporter
GWK28_01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWK28_01950	COG2854	intermembrane phospholipid transfer
GWK28_01960	COG0598	Magnesium transport protein CorA
GWK28_01970	COG0494	nUDIX hydrolase
GWK28_01975	COG1040	competence protein
GWK28_01980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK28_02000	COG1946	Acyl-CoA thioesterase
GWK28_02005	COG1301	dicarboxylic acid transport
GWK28_02020	COG1959	2 iron, 2 sulfur cluster binding
GWK28_02025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_02025	COG1017	nitric oxide dioxygenase activity
GWK28_02035	COG0433	COG0433 Predicted ATPase
GWK28_02040	COG0626	cystathionine gamma-synthase activity
GWK28_02195	COG1960	acyl-CoA dehydrogenase activity
GWK28_02200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWK28_02230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWK28_02235	COG0339	signal peptide processing
GWK28_02240	COG0557	exoribonuclease II activity
GWK28_02285	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK28_02290	COG2169	Transcriptional regulator
GWK28_02295	COG0697	spore germination
GWK28_02300	COG1295	ribonuclease BN
GWK28_02335	COG1702	phosphate starvation-inducible protein PhoH
GWK28_02345	COG0739	heme binding
GWK28_02345	COG0741	lytic transglycosylase activity
GWK28_02345	COG1196	nuclear chromosome segregation
GWK28_02375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWK28_02380	COG1183	phosphatidylcholine synthase activity
GWK28_02425	COG1960	acyl-CoA dehydrogenase activity
GWK28_02430	COG1309	transcriptional regulator
GWK28_02445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK28_02450	COG1960	acyl-CoA dehydrogenase activity
GWK28_02470	COG2969	positive regulation of protein catabolic process
GWK28_02480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWK28_02495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK28_02500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWK28_02520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWK28_02530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK28_02535	COG1408	metallophosphoesterase
GWK28_02545	COG2199	diguanylate cyclase activity
GWK28_02605	COG1607	acyl-coa hydrolase
GWK28_02635	COG2350	Protein conserved in bacteria
GWK28_02645	COG0613	PHP domain protein
GWK28_02650	COG3781	membrane
GWK28_02660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK28_02665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK28_02675	COG1862	Preprotein translocase
GWK28_02705	COG2205	protein histidine kinase activity
GWK28_02710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWK28_02725	COG0726	polysaccharide deacetylase
GWK28_02730	COG0438	transferase activity, transferring glycosyl groups
GWK28_02750	COG0438	transferase activity, transferring glycosyl groups
GWK28_02755	COG1215	transferase activity, transferring glycosyl groups
GWK28_02760	COG0438	transferase activity, transferring glycosyl groups
GWK28_02805	COG1960	acyl-CoA dehydrogenase activity
GWK28_02810	COG1960	acyl-CoA dehydrogenase activity
GWK28_02820	COG2205	protein histidine kinase activity
GWK28_02825	COG0745	RESPONSE REGULATOR receiver
GWK28_02830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWK28_02850	COG2096	Adenosyltransferase
GWK28_02900	COG0285	dihydrofolate synthase activity
GWK28_02920	COG0450	alkyl hydroperoxide reductase
GWK28_02935	COG0477	Major facilitator Superfamily
GWK28_02940	COG1272	protein, Hemolysin III
GWK28_02970	COG0183	Belongs to the thiolase family
GWK28_02975	COG2207	Transcriptional regulator
GWK28_02995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_03015	COG0183	Belongs to the thiolase family
GWK28_03025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWK28_03025	COG2885	chlorophyll binding
GWK28_03035	COG1690	Belongs to the RtcB family
GWK28_03040	COG0833	amino acid
GWK28_03050	COG2233	PERMEase
GWK28_03055	COG1217	gtp-binding protein TYPA
GWK28_03080	COG2094	Belongs to the DNA glycosylase MPG family
GWK28_03085	COG4772	TonB-dependent receptor
GWK28_03090	COG1902	pentaerythritol trinitrate reductase activity
GWK28_03095	COG0679	Auxin Efflux Carrier
GWK28_03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK28_03110	COG0354	folic acid binding
GWK28_03120	COG3189	MarR family transcriptional regulator
GWK28_03125	COG2824	Alkylphosphonate utilization operon protein PhnA
GWK28_03170	COG0840	transmembrane signaling receptor activity
GWK28_03190	COG5510	response to toxic substance
GWK28_03200	COG2832	Protein of unknown function (DUF454)
GWK28_03205	COG1376	ErfK ybiS ycfS ynhG family protein
GWK28_03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWK28_03255	COG1289	transmembrane transporter activity
GWK28_03260	COG2814	Major facilitator Superfamily
GWK28_03280	COG1115	amino acid carrier protein
GWK28_03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK28_03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK28_03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GWK28_03300	COG3590	peptidase
GWK28_03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK28_03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK28_03340	COG1077	Cell shape determining protein MreB Mrl
GWK28_03345	COG1792	Involved in formation and maintenance of cell shape
GWK28_03350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWK28_03355	COG0424	maF-like protein
GWK28_03360	COG1530	ribonuclease E activity
GWK28_03370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_03380	COG0560	Phosphoserine phosphatase
GWK28_03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_03415	COG2207	Transcriptional regulator
GWK28_03465	COG3328	transposase activity
GWK28_03480	COG0305	Participates in initiation and elongation during chromosome replication
GWK28_03525	COG0582	viral genome integration into host DNA
GWK28_03535	COG1113	amino acid transport
GWK28_03540	COG2828	Protein conserved in bacteria
GWK28_03545	COG0142	geranyltranstransferase activity
GWK28_03550	COG2315	Protein conserved in bacteria
GWK28_03565	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK28_03585	COG2194	sulfuric ester hydrolase activity
GWK28_03590	COG0745	RESPONSE REGULATOR receiver
GWK28_03595	COG0642	Histidine kinase
GWK28_03605	COG0004	ammonium transporteR
GWK28_03615	COG0525	valine-tRNA ligase activity
GWK28_03625	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_03635	COG0393	Putative heavy-metal-binding
GWK28_03640	COG0393	Putative heavy-metal-binding
GWK28_03645	COG1538	Outer membrane efflux protein
GWK28_03655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_03660	COG0671	phosphoesterase, PA-phosphatase related
GWK28_03690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWK28_03705	COG1648	precorrin-2 dehydrogenase activity
GWK28_03705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK28_03710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWK28_03715	COG1733	regulation of RNA biosynthetic process
GWK28_03725	COG0531	amino acid
GWK28_03740	COG0321	lipoyl(octanoyl) transferase activity
GWK28_03745	COG2921	Belongs to the UPF0250 family
GWK28_03780	COG2009	succinate dehydrogenase
GWK28_03785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWK28_03790	COG1053	succinate dehydrogenase
GWK28_03795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK28_03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK28_03840	COG2354	Protein conserved in bacteria
GWK28_03845	COG2321	neutral zinc metallopeptidase
GWK28_03865	COG2843	Capsule synthesis protein
GWK28_03880	COG0589	response to stress
GWK28_03900	COG0505	Belongs to the CarA family
GWK28_03925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK28_03930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK28_03980	COG0477	Major facilitator Superfamily
GWK28_03985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWK28_04000	COG1597	lipid kinase activity
GWK28_04005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWK28_04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_04030	COG0584	glycerophosphoryl diester phosphodiesterase
GWK28_04050	COG0741	lytic transglycosylase activity
GWK28_04070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWK28_04095	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK28_04100	COG0542	response to heat
GWK28_04150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK28_04190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWK28_04230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_04235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK28_04260	COG0778	Nitroreductase
GWK28_04265	COG0300	oxidoreductase activity
GWK28_04275	COG1929	Belongs to the glycerate kinase type-1 family
GWK28_04280	COG0243	molybdopterin cofactor binding
GWK28_04285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWK28_04290	COG3339	Conserved Protein
GWK28_04315	COG1113	amino acid transport
GWK28_04325	COG0019	diaminopimelate decarboxylase activity
GWK28_04335	COG1280	lysine exporter protein (LysE YggA)
GWK28_04340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWK28_04370	COG0463	Glycosyl transferase, family 2
GWK28_04390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_04425	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWK28_04430	COG1136	(ABC) transporter
GWK28_04435	COG0658	competence protein
GWK28_04435	COG2333	competence protein COMEC
GWK28_04445	COG0616	signal peptide processing
GWK28_04445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWK28_04450	COG0596	Alpha beta hydrolase
GWK28_04455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWK28_04465	COG0628	permease
GWK28_04500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK28_04520	COG0823	Involved in the tonB-independent uptake of proteins
GWK28_04540	COG0824	Thioesterase
GWK28_04545	COG1473	amidohydrolase
GWK28_04565	COG0047	phosphoribosylformylglycinamidine synthase activity
GWK28_04565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWK28_04570	COG2814	Major facilitator Superfamily
GWK28_04580	COG1024	Enoyl-CoA hydratase
GWK28_04585	COG1051	belongs to the nudix hydrolase family
GWK28_04585	COG1056	cytidyltransferase-related domain
GWK28_04595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK28_04610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWK28_04625	COG4625	pathogenesis
GWK28_04630	COG0583	DNA-binding transcription factor activity
GWK28_04635	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWK28_04640	COG4208	sulfate ABC transporter
GWK28_04645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWK28_04655	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWK28_04660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK28_04665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWK28_04685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK28_04700	COG0681	Belongs to the peptidase S26 family
GWK28_04715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWK28_04725	COG1381	Involved in DNA repair and RecF pathway recombination
GWK28_04730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWK28_04740	COG4221	oxidoreductase activity
GWK28_04770	COG0436	Aminotransferase
GWK28_04790	COG0556	nucleotide-excision repair
GWK28_04845	COG2070	2-Nitropropane dioxygenase
GWK28_04875	COG1215	transferase activity, transferring glycosyl groups
GWK28_04890	COG0415	Belongs to the DNA photolyase family
GWK28_04900	COG1252	NADH dehydrogenase
GWK28_04905	COG1686	Belongs to the peptidase S11 family
GWK28_04920	COG1187	pseudouridine synthase activity
GWK28_04945	COG0477	Major facilitator Superfamily
GWK28_04950	COG0583	DNA-binding transcription factor activity
GWK28_04955	COG1823	symporter activity
GWK28_04965	COG0612	Peptidase, M16
GWK28_04990	COG0352	thiamine-phosphate diphosphorylase activity
GWK28_05025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_05040	COG1309	transcriptional regulator
GWK28_05050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK28_05055	COG0076	glutamate decarboxylase activity
GWK28_05065	COG1522	sequence-specific DNA binding
GWK28_05070	COG3961	Belongs to the TPP enzyme family
GWK28_05075	COG1113	amino acid transport
GWK28_05080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWK28_05085	COG0573	inorganic phosphate transmembrane transporter activity
GWK28_05095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK28_05100	COG0616	signal peptide processing
GWK28_05135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWK28_05140	COG1686	Belongs to the peptidase S11 family
GWK28_05165	COG0583	DNA-binding transcription factor activity
GWK28_05170	COG1067	ATP-dependent peptidase activity
GWK28_05175	COG2211	Major facilitator Superfamily
GWK28_05215	COG1966	Carbon starvation protein
GWK28_05220	COG2879	small protein
GWK28_05230	COG0653	protein targeting
GWK28_05240	COG1741	Belongs to the pirin family
GWK28_05250	COG2964	Protein conserved in bacteria
GWK28_05265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_05270	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK28_05275	COG4605	iron ion homeostasis
GWK28_05280	COG4604	ABC transporter, ATP-binding protein
GWK28_05285	COG4607	ABC-type enterochelin transport system periplasmic component
GWK28_05290	COG4774	siderophore transport
GWK28_05300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_05305	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWK28_05310	COG3433	isochorismatase activity
GWK28_05310	COG1535	isochorismatase
GWK28_05325	COG1132	(ABC) transporter
GWK28_05330	COG1132	(ABC) transporter
GWK28_05335	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GWK28_05340	COG2977	Belongs to the P-Pant transferase superfamily
GWK28_05345	COG1169	isochorismate synthase
GWK28_05360	COG3739	integral membrane protein
GWK28_05380	COG0302	gtp cyclohydrolase
GWK28_05390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWK28_05400	COG2840	Smr protein MutS2
GWK28_05420	COG0308	aminopeptidase N
GWK28_05425	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK28_05440	COG0174	glutamine synthetase
GWK28_05450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWK28_05485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK28_05490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWK28_05495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK28_05515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK28_05520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GWK28_05525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWK28_05540	COG1960	acyl-CoA dehydrogenase activity
GWK28_05545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWK28_05550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK28_05560	COG2223	nitrite transmembrane transporter activity
GWK28_05570	COG0024	Methionine aminopeptidase
GWK28_05575	COG0052	Belongs to the universal ribosomal protein uS2 family
GWK28_05590	COG2207	Transcriptional regulator
GWK28_05615	COG2951	lytic endotransglycosylase activity
GWK28_05620	COG0772	Belongs to the SEDS family
GWK28_05635	COG0842	Transport permease protein
GWK28_05640	COG1131	(ABC) transporter
GWK28_05685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_05700	COG4215	(ABC) transporter
GWK28_05705	COG4160	amino acid transport
GWK28_05710	COG4598	ABC transporter
GWK28_05720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWK28_05725	COG0826	peptidase U32
GWK28_05730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_05755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK28_05770	COG0642	Histidine kinase
GWK28_05780	COG0494	nUDIX hydrolase
GWK28_05790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK28_05795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK28_05800	COG3139	Protein of unknown function (DUF1315)
GWK28_05805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK28_05810	COG1301	dicarboxylic acid transport
GWK28_05820	COG2819	hydrolase of the alpha beta superfamily
GWK28_05830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWK28_05840	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK28_05860	COG1690	Belongs to the RtcB family
GWK28_05865	COG1234	tRNA 3'-trailer cleavage
GWK28_05870	COG4650	regulator
GWK28_05900	COG2363	Small membrane protein
GWK28_05920	COG0513	Belongs to the DEAD box helicase family
GWK28_05930	COG0778	Nitroreductase
GWK28_05960	COG1286	toxin biosynthetic process
GWK28_05985	COG4783	chaperone-mediated protein folding
GWK28_05990	COG1610	YqeY-like protein
GWK28_06020	COG2815	serine threonine protein kinase
GWK28_06020	COG0515	serine threonine protein kinase
GWK28_06045	COG2831	hemolysin activation secretion protein
GWK28_06055	COG3328	transposase activity
GWK28_06165	COG3111	PFAM Bacterial OB fold (BOF) protein
GWK28_06200	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWK28_06205	COG0786	glutamate:sodium symporter activity
GWK28_06215	COG2186	Transcriptional regulator
GWK28_06265	COG3328	transposase activity
GWK28_06270	COG0477	Major facilitator Superfamily
GWK28_06295	COG2995	paraquat-inducible protein a
GWK28_06300	COG3008	intermembrane lipid transfer
GWK28_06300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWK28_06310	COG2351	hydroxyisourate hydrolase activity
GWK28_06350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWK28_06360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWK28_06365	COG0642	Histidine kinase
GWK28_06370	COG0745	RESPONSE REGULATOR receiver
GWK28_06395	COG1794	racemase activity, acting on amino acids and derivatives
GWK28_06425	COG1301	dicarboxylic acid transport
GWK28_06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_06440	COG2011	ABC-type metal ion transport system permease component
GWK28_06445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK28_06450	COG1464	Belongs to the NlpA lipoprotein family
GWK28_06455	COG0151	Belongs to the GarS family
GWK28_06460	COG0138	bifunctional purine biosynthesis protein purh
GWK28_06465	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWK28_06495	COG2308	Evidence 4 Homologs of previously reported genes of
GWK28_06505	COG1305	Transglutaminase-like
GWK28_06515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWK28_06520	COG0305	Participates in initiation and elongation during chromosome replication
GWK28_06545	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK28_06555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK28_06560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK28_06585	COG0726	polysaccharide deacetylase
GWK28_06585	COG1649	PFAM Uncharacterised BCR, COG1649
GWK28_06590	COG1215	transferase activity, transferring glycosyl groups
GWK28_06595	COG3658	cytochrome
GWK28_06605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK28_06620	COG0583	DNA-binding transcription factor activity
GWK28_06650	COG1960	acyl-CoA dehydrogenase activity
GWK28_06655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK28_06660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_06685	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GWK28_06690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GWK28_06700	COG2205	protein histidine kinase activity
GWK28_06705	COG0745	RESPONSE REGULATOR receiver
GWK28_06710	COG0174	glutamine synthetase
GWK28_06730	COG0729	surface antigen
GWK28_06755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK28_06760	COG2814	Major facilitator Superfamily
GWK28_06775	COG0583	DNA-binding transcription factor activity
GWK28_06790	COG1187	pseudouridine synthase activity
GWK28_06810	COG0802	atpase or kinase
GWK28_06815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK28_06825	COG1923	regulation of RNA biosynthetic process
GWK28_06830	COG0697	spore germination
GWK28_06855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK28_06860	COG0519	Catalyzes the synthesis of GMP from XMP
GWK28_06860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK28_06865	COG4302	ethanolamine ammonia-lyase activity
GWK28_06870	COG4303	Ethanolamine ammonia lyase large subunit
GWK28_06875	COG0531	amino acid
GWK28_06895	COG1454	alcohol dehydrogenase
GWK28_06900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK28_06910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GWK28_06930	COG0308	aminopeptidase N
GWK28_06950	COG1605	Chorismate mutase
GWK28_06965	COG1309	transcriptional regulator
GWK28_06975	COG0668	transmembrane transport
GWK28_07005	COG4773	Receptor
GWK28_07025	COG0488	(ABC) transporter
GWK28_07030	COG0589	response to stress
GWK28_07060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GWK28_07070	COG3135	benzoate transporter
GWK28_07075	COG1522	sequence-specific DNA binding
GWK28_07085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWK28_07090	COG0583	DNA-binding transcription factor activity
GWK28_07100	COG0183	Belongs to the thiolase family
GWK28_07110	COG2030	dehydratase
GWK28_07115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK28_07140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWK28_07155	COG0824	Thioesterase
GWK28_07160	COG1454	alcohol dehydrogenase
GWK28_07170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK28_07190	COG0069	glutamate synthase activity
GWK28_07220	COG1484	DNA-dependent DNA replication
GWK28_07435	COG2814	Major facilitator Superfamily
GWK28_07450	COG0511	ligase activity, forming carbon-carbon bonds
GWK28_07465	COG3328	transposase activity
GWK28_07500	COG1196	nuclear chromosome segregation
GWK28_07515	COG1116	anion transmembrane transporter activity
GWK28_07515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK28_07520	COG0745	RESPONSE REGULATOR receiver
GWK28_07530	COG2146	nitrite reductase [NAD(P)H] activity
GWK28_07530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_07535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_07540	COG0243	molybdopterin cofactor binding
GWK28_07550	COG0243	molybdopterin cofactor binding
GWK28_07555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK28_07570	COG0315	cyclic pyranopterin monophosphate synthase activity
GWK28_07570	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWK28_07585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_07590	COG0697	spore germination
GWK28_07610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWK28_07615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK28_07670	COG2204	response regulator
GWK28_07675	COG3852	Histidine kinase
GWK28_07700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK28_07705	COG0575	Belongs to the CDS family
GWK28_07740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWK28_07755	COG2137	regulation of response to DNA damage stimulus
GWK28_07765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GWK28_07770	COG1011	Hydrolase
GWK28_07795	COG1522	sequence-specific DNA binding
GWK28_07805	COG1113	amino acid transport
GWK28_07820	COG0659	secondary active sulfate transmembrane transporter activity
GWK28_07825	COG2135	peptidase activity
GWK28_07840	COG3300	MHYT domain
GWK28_07840	COG5001	Diguanylate cyclase
GWK28_07855	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWK28_07855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK28_07855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK28_07860	COG1105	Belongs to the carbohydrate kinase PfkB family
GWK28_07865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWK28_07865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK28_07895	COG0024	Methionine aminopeptidase
GWK28_07900	COG0583	DNA-binding transcription factor activity
GWK28_07910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWK28_07915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK28_07920	COG0516	GMP reductase activity
GWK28_07920	COG0517	IMP dehydrogenase activity
GWK28_07945	COG0552	protein localization to endoplasmic reticulum
GWK28_07955	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWK28_07965	COG4890	Cyd operon protein YbgT
GWK28_07970	COG1294	oxidase, subunit
GWK28_07985	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWK28_07995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK28_08000	COG4774	siderophore transport
GWK28_08015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK28_08020	COG0569	domain protein
GWK28_08025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK28_08055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWK28_08060	COG0542	response to heat
GWK28_08085	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK28_08085	COG1902	pentaerythritol trinitrate reductase activity
GWK28_08130	COG2323	membrane
GWK28_08135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWK28_08145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_08150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_08155	COG0183	Belongs to the thiolase family
GWK28_08160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK28_08165	COG0596	Alpha beta hydrolase
GWK28_08170	COG2271	Major facilitator Superfamily
GWK28_08175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK28_08180	COG3485	protocatechuate 3,4-dioxygenase
GWK28_08185	COG3485	protocatechuate 3,4-dioxygenase
GWK28_08190	COG0710	3-dehydroquinate dehydratase activity
GWK28_08195	COG3420	alginic acid biosynthetic process
GWK28_08200	COG3659	wide pore channel activity
GWK28_08215	COG2391	methyltransferase activity
GWK28_08230	COG1414	Transcriptional regulator
GWK28_08235	COG0583	DNA-binding transcription factor activity
GWK28_08240	COG1960	acyl-CoA dehydrogenase activity
GWK28_08265	COG2814	Major facilitator Superfamily
GWK28_08275	COG0154	amidase activity
GWK28_08295	COG4638	Rieske (2fe-2S)
GWK28_08305	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_08315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_08325	COG3733	amine oxidase
GWK28_08335	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_08340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK28_08345	COG0183	Belongs to the thiolase family
GWK28_08350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_08355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_08365	COG4829	muconolactone delta-isomerase
GWK28_08370	COG4948	Mandelate Racemase Muconate Lactonizing
GWK28_08375	COG0583	DNA-binding transcription factor activity
GWK28_08385	COG2186	Transcriptional regulator
GWK28_08405	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_08430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWK28_08440	COG0789	Transcriptional regulator
GWK28_08455	COG1309	transcriptional regulator
GWK28_08500	COG2188	Transcriptional regulator
GWK28_08515	COG0583	DNA-binding transcription factor activity
GWK28_08530	COG1566	PFAM secretion protein HlyD family protein
GWK28_08545	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_08550	COG0129	dihydroxy-acid dehydratase activity
GWK28_08560	COG0583	DNA-binding transcription factor activity
GWK28_08565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK28_08575	COG2084	Dehydrogenase
GWK28_08580	COG2207	Transcriptional regulator
GWK28_08595	COG1064	alcohol dehydrogenase
GWK28_08605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK28_08610	COG1120	ATPase activity
GWK28_08630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK28_08680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWK28_08735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_08790	COG0753	catalase activity
GWK28_08805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK28_08870	COG1535	isochorismatase
GWK28_08870	COG3433	isochorismatase activity
GWK28_08875	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_08880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWK28_08885	COG4149	molybdate abc transporter
GWK28_08890	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWK28_08900	COG4638	Rieske (2fe-2S)
GWK28_08905	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GWK28_08910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_08910	COG0543	2 iron, 2 sulfur cluster binding
GWK28_08925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_08935	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_08950	COG2207	Transcriptional regulator
GWK28_08955	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_08960	COG2610	gluconate transmembrane transporter activity
GWK28_08970	COG1309	transcriptional regulator
GWK28_08990	COG0583	DNA-binding transcription factor activity
GWK28_09005	COG2031	fatty acid transporter
GWK28_09010	COG0183	Belongs to the thiolase family
GWK28_09015	COG0583	DNA-binding transcription factor activity
GWK28_09020	COG0583	DNA-binding transcription factor activity
GWK28_09035	COG1027	Aspartate ammonia-lyase
GWK28_09065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK28_09070	COG4521	taurine ABC transporter
GWK28_09085	COG2188	Transcriptional regulator
GWK28_09095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWK28_09100	COG1733	regulation of RNA biosynthetic process
GWK28_09105	COG2207	Transcriptional regulator
GWK28_09105	COG3708	Transcriptional regulator
GWK28_09120	COG0730	response to heat
GWK28_09130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_09130	COG3453	Protein conserved in bacteria
GWK28_09140	COG3781	membrane
GWK28_09145	COG1063	alcohol dehydrogenase
GWK28_09155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK28_09160	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK28_09165	COG0022	dehydrogenase e1 component
GWK28_09170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK28_09175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWK28_09190	COG3706	GGDEF domain
GWK28_09205	COG0133	tryptophan synthase activity
GWK28_09215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK28_09250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWK28_09275	COG2226	methyltransferase
GWK28_09330	COG0842	Transport permease protein
GWK28_09335	COG0842	Transport permease protein
GWK28_09340	COG1131	(ABC) transporter
GWK28_09355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWK28_09360	COG4773	Receptor
GWK28_09380	COG0730	response to heat
GWK28_09385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWK28_09400	COG0406	alpha-ribazole phosphatase activity
GWK28_09405	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GWK28_09420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK28_09450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWK28_09460	COG4264	IucA IucC family
GWK28_09465	COG4264	IucA IucC family
GWK28_09470	COG2814	Major facilitator Superfamily
GWK28_09485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWK28_09500	COG1960	acyl-CoA dehydrogenase activity
GWK28_09505	COG1960	acyl-CoA dehydrogenase activity
GWK28_09510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_09515	COG2207	Transcriptional regulator
GWK28_09520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK28_09525	COG0776	regulation of translation
GWK28_09550	COG0822	iron-sulfur transferase activity
GWK28_09555	COG0316	Belongs to the HesB IscA family
GWK28_09585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK28_09605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWK28_09610	COG0702	epimerase
GWK28_09645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK28_09655	COG0339	signal peptide processing
GWK28_09705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWK28_09710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWK28_09740	COG0776	regulation of translation
GWK28_09805	COG0084	hydrolase, TatD family'
GWK28_09825	COG1663	tetraacyldisaccharide 4'-kinase activity
GWK28_09830	COG1132	(ABC) transporter
GWK28_09840	COG0811	peptide transport
GWK28_09845	COG1475	DNA binding
GWK28_09850	COG1192	Involved in chromosome partitioning
GWK28_09860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK28_09875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK28_09880	COG0191	fructose-bisphosphate aldolase activity
GWK28_09900	COG0424	maF-like protein
GWK28_09905	COG2850	peptidyl-arginine hydroxylation
GWK28_09915	COG0640	Transcriptional regulator
GWK28_09925	COG3619	membrane
GWK28_09930	COG3122	Protein conserved in bacteria
GWK28_09935	COG1132	(ABC) transporter
GWK28_09955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWK28_09960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK28_09970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWK28_09970	COG0506	proline dehydrogenase activity
GWK28_09970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWK28_09975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWK28_09990	COG3698	Phosphodiester glycosidase
GWK28_10000	COG2353	YceI-like domain
GWK28_10010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWK28_10055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWK28_10055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK28_10080	COG3539	Fimbrial protein
GWK28_10085	COG3121	Chaperone
GWK28_10120	COG0697	spore germination
GWK28_10135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK28_10145	COG0583	DNA-binding transcription factor activity
GWK28_10165	COG1309	transcriptional regulator
GWK28_10180	COG1522	sequence-specific DNA binding
GWK28_10195	COG1126	abc transporter atp-binding protein
GWK28_10200	COG0765	amino acid transport
GWK28_10205	COG0765	amino acid transport
GWK28_10235	COG1464	Belongs to the NlpA lipoprotein family
GWK28_10245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK28_10250	COG2011	ABC-type metal ion transport system permease component
GWK28_10255	COG0012	GTP binding
GWK28_10280	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GWK28_10320	COG0386	Belongs to the glutathione peroxidase family
GWK28_10330	COG0436	Aminotransferase
GWK28_10335	COG1301	dicarboxylic acid transport
GWK28_10370	COG3634	alkyl hydroperoxide reductase activity
GWK28_10385	COG0583	DNA-binding transcription factor activity
GWK28_10390	COG0798	PFAM Bile acid sodium symporter
GWK28_10395	COG0640	Transcriptional regulator
GWK28_10410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWK28_10425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK28_10430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWK28_10435	COG4521	taurine ABC transporter
GWK28_10445	COG0477	Major facilitator Superfamily
GWK28_10465	COG1271	oxidase subunit
GWK28_10470	COG1294	oxidase, subunit
GWK28_10480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_10500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWK28_10520	COG3052	prosthetic group binding
GWK28_10525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GWK28_10535	COG0300	oxidoreductase activity
GWK28_10555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_10560	COG1346	cytolysis
GWK28_10570	COG0583	DNA-binding transcription factor activity
GWK28_10575	COG0625	glutathione transferase activity
GWK28_10580	COG0625	glutathione transferase activity
GWK28_10585	COG0583	DNA-binding transcription factor activity
GWK28_10600	COG1045	serine acetyltransferase
GWK28_10605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK28_10610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK28_10615	COG1280	lysine exporter protein (LysE YggA)
GWK28_10625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK28_10630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK28_10640	COG0765	amino acid transport
GWK28_10645	COG0765	amino acid transport
GWK28_10665	COG2205	protein histidine kinase activity
GWK28_10665	COG0784	Response regulator, receiver
GWK28_10705	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_10755	COG0583	DNA-binding transcription factor activity
GWK28_10775	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_10780	COG1309	transcriptional regulator
GWK28_10785	COG1960	acyl-CoA dehydrogenase activity
GWK28_10790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK28_10795	COG1024	Enoyl-CoA hydratase
GWK28_10800	COG4770	biotin carboxylase activity
GWK28_10810	COG0583	DNA-binding transcription factor activity
GWK28_10825	COG1960	acyl-CoA dehydrogenase activity
GWK28_10835	COG2814	Major facilitator Superfamily
GWK28_10845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_10850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_10855	COG2814	Major facilitator Superfamily
GWK28_10860	COG1960	acyl-CoA dehydrogenase activity
GWK28_10865	COG1024	Enoyl-CoA hydratase
GWK28_10870	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_10875	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK28_10880	COG0183	Belongs to the thiolase family
GWK28_10890	COG2814	Major facilitator Superfamily
GWK28_10900	COG1024	Enoyl-CoA hydratase
GWK28_10910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK28_10915	COG1960	acyl-CoA dehydrogenase activity
GWK28_10920	COG2814	Major facilitator Superfamily
GWK28_10925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK28_10930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK28_10945	COG3842	ATPase activity
GWK28_10950	COG1840	ABC-type Fe3 transport system, periplasmic component
GWK28_10960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_10965	COG1414	Transcriptional regulator
GWK28_10975	COG0583	DNA-binding transcription factor activity
GWK28_10980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK28_10985	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_10995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK28_11005	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_11010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK28_11015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_11020	COG2267	carboxylic ester hydrolase activity
GWK28_11040	COG3038	cytochrome b561
GWK28_11045	COG0753	catalase activity
GWK28_11050	COG2271	Major facilitator Superfamily
GWK28_11055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK28_11060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK28_11090	COG1278	Cold shock
GWK28_11140	COG2050	protein possibly involved in aromatic compounds catabolism
GWK28_11150	COG3327	negative regulation of DNA-templated transcription, initiation
GWK28_11155	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GWK28_11160	COG0183	Belongs to the thiolase family
GWK28_11165	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK28_11170	COG1024	Enoyl-CoA hydratase
GWK28_11175	COG1024	Enoyl-CoA hydratase
GWK28_11180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_11185	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK28_11190	COG3396	Phenylacetate-CoA oxygenase
GWK28_11195	COG3460	Phenylacetate-CoA oxygenase
GWK28_11200	COG3396	Phenylacetate-CoA oxygenase
GWK28_11205	COG2030	dehydratase
GWK28_11205	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_11210	COG1760	l-serine dehydratase
GWK28_11215	COG0531	amino acid
GWK28_11220	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_11245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK28_11265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_11310	COG1116	anion transmembrane transporter activity
GWK28_11315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK28_11325	COG0864	Transcriptional regulator
GWK28_11335	COG1733	regulation of RNA biosynthetic process
GWK28_11340	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_11345	COG0439	Biotin carboxylase
GWK28_11360	COG1063	alcohol dehydrogenase
GWK28_11370	COG1309	transcriptional regulator
GWK28_11380	COG0038	chloride channel
GWK28_11385	COG4770	biotin carboxylase activity
GWK28_11405	COG1914	H( )-stimulated, divalent metal cation uptake system
GWK28_11410	COG0583	DNA-binding transcription factor activity
GWK28_11445	COG3209	COG3209 Rhs family protein
GWK28_11475	COG1011	Hydrolase
GWK28_11495	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK28_11510	COG3328	transposase activity
GWK28_11530	COG2814	Major facilitator Superfamily
GWK28_11540	COG1560	Kdo2-lipid A biosynthetic process
GWK28_11550	COG5006	permease, DMT superfamily
GWK28_11555	COG1522	sequence-specific DNA binding
GWK28_11570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWK28_11580	COG4122	O-methyltransferase activity
GWK28_11610	COG1538	Outer membrane efflux protein
GWK28_11615	COG1137	ATPase activity
GWK28_11620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWK28_11630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWK28_11635	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWK28_11635	COG0517	IMP dehydrogenase activity
GWK28_11675	COG2814	Major facilitator Superfamily
GWK28_11710	COG1278	Cold shock
GWK28_11715	COG1280	lysine exporter protein (LysE YggA)
GWK28_11750	COG1570	exodeoxyribonuclease VII activity
GWK28_11830	COG2871	sodium ion transport
GWK28_11840	COG0583	DNA-binding transcription factor activity
GWK28_11850	COG4638	Rieske (2fe-2S)
GWK28_11855	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GWK28_11860	COG0543	2 iron, 2 sulfur cluster binding
GWK28_11860	COG0633	Ferredoxin
GWK28_11865	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_11870	COG3135	benzoate transporter
GWK28_11875	COG2814	Major facilitator Superfamily
GWK28_11890	COG1643	Atp-dependent helicase
GWK28_11895	COG0450	alkyl hydroperoxide reductase
GWK28_11905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWK28_11915	COG3634	alkyl hydroperoxide reductase activity
GWK28_11935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWK28_11940	COG0625	glutathione transferase activity
GWK28_11950	COG2885	chlorophyll binding
GWK28_11985	COG0542	response to heat
GWK28_12000	COG1765	OsmC-like protein
GWK28_12010	COG0667	Aldo Keto reductase
GWK28_12025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWK28_12035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK28_12045	COG0582	viral genome integration into host DNA
GWK28_12085	COG3179	chitinase
GWK28_12180	COG3566	protein conserved in bacteria
GWK28_12195	COG3567	Phage-associated protein, HI1409 family
GWK28_12200	COG5410	chromosome segregation
GWK28_12245	COG0527	aspartate kinase activity
GWK28_12255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWK28_12265	COG3038	cytochrome b561
GWK28_12270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWK28_12275	COG2252	PERMEase
GWK28_12285	COG2072	flavoprotein involved in K transport
GWK28_12300	COG1741	Belongs to the pirin family
GWK28_12305	COG1309	transcriptional regulator
GWK28_12315	COG0300	oxidoreductase activity
GWK28_12320	COG2072	flavoprotein involved in K transport
GWK28_12325	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWK28_12330	COG0583	DNA-binding transcription factor activity
GWK28_12345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK28_12390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWK28_12405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_12420	COG2814	Major facilitator Superfamily
GWK28_12425	COG1024	Enoyl-CoA hydratase
GWK28_12430	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_12440	COG1960	acyl-CoA dehydrogenase activity
GWK28_12465	COG2186	Transcriptional regulator
GWK28_12470	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_12480	COG4948	Mandelate Racemase Muconate Lactonizing
GWK28_12490	COG2721	sulfolactate sulfo-lyase activity
GWK28_12495	COG0697	spore germination
GWK28_12510	COG1113	amino acid transport
GWK28_12530	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_12550	COG0531	amino acid
GWK28_12560	COG1113	amino acid transport
GWK28_12595	COG0183	Belongs to the thiolase family
GWK28_12600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_12605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_12620	COG3485	protocatechuate 3,4-dioxygenase
GWK28_12625	COG1454	alcohol dehydrogenase
GWK28_12630	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_12650	COG2814	Major facilitator Superfamily
GWK28_12660	COG0583	DNA-binding transcription factor activity
GWK28_12670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWK28_12710	COG2059	Chromate
GWK28_12720	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GWK28_12730	COG1230	cation diffusion facilitator family transporter
GWK28_12745	COG2814	Major facilitator Superfamily
GWK28_12810	COG3328	transposase activity
GWK28_12860	COG0582	viral genome integration into host DNA
GWK28_12870	COG1902	pentaerythritol trinitrate reductase activity
GWK28_12870	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK28_12895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK28_12915	COG4172	Belongs to the ABC transporter superfamily
GWK28_12920	COG4239	(ABC) transporter, permease
GWK28_12925	COG4174	ABC transporter (Permease)
GWK28_12935	COG0741	lytic transglycosylase activity
GWK28_12935	COG1388	LysM domain
GWK28_12935	COG0741	lytic transglycosylase activity
GWK28_12935	COG1388	LysM domain
GWK28_12940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK28_12980	COG0583	DNA-binding transcription factor activity
GWK28_12985	COG1279	arginine transmembrane transporter activity
GWK28_13005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_13010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_13015	COG0006	proline dipeptidase activity
GWK28_13055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWK28_13075	COG3384	dioxygenase
GWK28_13085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK28_13090	COG2878	Part of a membrane complex involved in electron transport
GWK28_13095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK28_13120	COG0768	penicillin binding
GWK28_13125	COG0742	ribosomal rna small subunit methyltransferase
GWK28_13140	COG0830	nickel cation binding
GWK28_13150	COG0804	urea catabolic process
GWK28_13190	COG1253	flavin adenine dinucleotide binding
GWK28_13195	COG2851	Citrate transporter
GWK28_13245	COG1773	rubredoxin
GWK28_13250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_13260	COG0583	DNA-binding transcription factor activity
GWK28_13290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWK28_13295	COG4181	ATPase activity
GWK28_13340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWK28_13360	COG0306	phosphate transporter
GWK28_13370	COG3958	Transketolase
GWK28_13375	COG3959	Transketolase, thiamine diphosphate binding domain
GWK28_13380	COG2271	Major facilitator Superfamily
GWK28_13385	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_13390	COG0583	DNA-binding transcription factor activity
GWK28_13405	COG2223	nitrite transmembrane transporter activity
GWK28_13410	COG2207	Transcriptional regulator
GWK28_13415	COG2066	Belongs to the glutaminase family
GWK28_13420	COG0242	peptide deformylase activity
GWK28_13425	COG0477	Major facilitator Superfamily
GWK28_13435	COG0028	Belongs to the TPP enzyme family
GWK28_13450	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_13455	COG2267	carboxylic ester hydrolase activity
GWK28_13465	COG2271	Major facilitator Superfamily
GWK28_13500	COG1414	Transcriptional regulator
GWK28_13515	COG1024	Enoyl-CoA hydratase
GWK28_13525	COG1215	transferase activity, transferring glycosyl groups
GWK28_13530	COG1649	PFAM Uncharacterised BCR, COG1649
GWK28_13530	COG0726	polysaccharide deacetylase
GWK28_13540	COG4681	YaeQ
GWK28_13550	COG0523	cobalamin synthesis protein
GWK28_13560	COG1607	acyl-coa hydrolase
GWK28_13570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK28_13575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK28_13580	COG1309	transcriptional regulator
GWK28_13605	COG2040	homocysteine
GWK28_13610	COG0531	amino acid
GWK28_13665	COG1595	DNA-templated transcription, initiation
GWK28_13675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_13680	COG0477	Major facilitator Superfamily
GWK28_13825	COG3617	BRO family, N-terminal domain
GWK28_13845	COG0582	viral genome integration into host DNA
GWK28_13855	COG0405	Gamma-glutamyltransferase
GWK28_13860	COG2814	Major facilitator Superfamily
GWK28_13870	COG2050	protein possibly involved in aromatic compounds catabolism
GWK28_13885	COG1090	epimerase
GWK28_13905	COG0420	3'-5' exonuclease activity
GWK28_13930	COG0735	belongs to the Fur family
GWK28_13935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWK28_13955	COG0121	glutamine amidotransferase
GWK28_13970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK28_13980	COG0210	DNA helicase
GWK28_13985	COG2885	chlorophyll binding
GWK28_13990	COG0204	Acyl-transferase
GWK28_14005	COG2894	cell division
GWK28_14025	COG1280	lysine exporter protein (LysE YggA)
GWK28_14030	COG1674	ftsk spoiiie
GWK28_14030	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWK28_14035	COG0492	ferredoxin-NADP+ reductase activity
GWK28_14040	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWK28_14050	COG0456	acetyltransferase
GWK28_14095	COG1981	membrane
GWK28_14110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWK28_14110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWK28_14130	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_14140	COG0657	acetylesterase activity
GWK28_14150	COG0473	3-isopropylmalate dehydrogenase activity
GWK28_14155	COG0583	DNA-binding transcription factor activity
GWK28_14175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWK28_14200	COG0564	pseudouridine synthase activity
GWK28_14210	COG0358	DNA primase activity
GWK28_14225	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWK28_14255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK28_14285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK28_14295	COG0351	phosphomethylpyrimidine kinase
GWK28_14295	COG0352	thiamine-phosphate diphosphorylase activity
GWK28_14295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK28_14300	COG1652	LysM domain
GWK28_14325	COG1399	metal-binding, possibly nucleic acid-binding protein
GWK28_14330	COG3101	peptidyl-lysine hydroxylation
GWK28_14335	COG0009	L-threonylcarbamoyladenylate synthase
GWK28_14340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWK28_14345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWK28_14360	COG4106	trans-aconitate 2-methyltransferase activity
GWK28_14375	COG2226	methyltransferase
GWK28_14375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK28_14375	COG0596	Alpha beta hydrolase
GWK28_14380	COG1877	trehalose-phosphatase activity
GWK28_14385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GWK28_14390	COG2223	nitrite transmembrane transporter activity
GWK28_14410	COG1196	nuclear chromosome segregation
GWK28_14420	COG0730	response to heat
GWK28_14435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK28_14445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK28_14495	COG0489	protein tyrosine kinase activity
GWK28_14505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK28_14505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK28_14535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GWK28_14540	COG2081	HI0933 family
GWK28_14550	COG0668	transmembrane transport
GWK28_14570	COG0583	DNA-binding transcription factor activity
GWK28_14590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK28_14595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK28_14625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GWK28_14665	COG0745	RESPONSE REGULATOR receiver
GWK28_14685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK28_14695	COG0384	phenazine biosynthesis protein PhzF
GWK28_14720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_14735	COG0583	DNA-binding transcription factor activity
GWK28_14770	COG0583	DNA-binding transcription factor activity
GWK28_14785	COG0583	DNA-binding transcription factor activity
GWK28_14790	COG1053	succinate dehydrogenase
GWK28_14800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK28_14805	COG2814	Major facilitator Superfamily
GWK28_14810	COG1960	acyl-CoA dehydrogenase activity
GWK28_14815	COG0583	DNA-binding transcription factor activity
GWK28_14820	COG1063	alcohol dehydrogenase
GWK28_14850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWK28_14855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GWK28_14860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK28_14880	COG2132	Multicopper oxidase
GWK28_14890	COG0561	phosphatase activity
GWK28_14895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWK28_14920	COG1214	PFAM Peptidase M22, glycoprotease
GWK28_14965	COG1388	LysM domain
GWK28_14965	COG1134	teichoic acid transport
GWK28_14970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK28_14980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK28_14985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWK28_14990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWK28_15050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWK28_15060	COG1846	Transcriptional regulator
GWK28_15065	COG1764	response to oxidative stress
GWK28_15105	COG0037	tRNA processing
GWK28_15115	COG0248	Ppx GppA phosphatase
GWK28_15145	COG0072	phenylalanine-tRNA ligase activity
GWK28_15195	COG1238	metal cluster binding
GWK28_15200	COG0625	glutathione transferase activity
GWK28_15215	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_15220	COG3028	Belongs to the UPF0307 family
GWK28_15225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK28_15245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWK28_15250	COG0617	tRNA 3'-terminal CCA addition
GWK28_15255	COG1555	photosystem II stabilization
GWK28_15260	COG3956	TIGRFAM MazG family protein
GWK28_15270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK28_15290	COG0784	Response regulator, receiver
GWK28_15290	COG2205	protein histidine kinase activity
GWK28_15290	COG5002	protein histidine kinase activity
GWK28_15295	COG1024	Enoyl-CoA hydratase
GWK28_15300	COG2084	Dehydrogenase
GWK28_15305	COG3622	Belongs to the hyi family
GWK28_15335	COG0697	spore germination
GWK28_15345	COG2814	Major facilitator Superfamily
GWK28_15355	COG3328	transposase activity
GWK28_15365	COG0492	ferredoxin-NADP+ reductase activity
GWK28_15370	COG0431	NADPH-dependent FMN reductase
GWK28_15375	COG0798	PFAM Bile acid sodium symporter
GWK28_15385	COG0640	Transcriptional regulator
GWK28_15420	COG3328	transposase activity
GWK28_15435	COG2132	Multicopper oxidase
GWK28_15450	COG2205	protein histidine kinase activity
GWK28_15485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK28_15495	COG0583	DNA-binding transcription factor activity
GWK28_15505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWK28_15520	COG0084	hydrolase, TatD family'
GWK28_15535	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWK28_15560	COG2130	NADP-dependent
GWK28_15565	COG1309	transcriptional regulator
GWK28_15585	COG1979	alcohol dehydrogenase
GWK28_15595	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GWK28_15610	COG0604	alcohol dehydrogenase
GWK28_15610	COG3321	synthase
GWK28_15615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GWK28_15620	COG0583	DNA-binding transcription factor activity
GWK28_15625	COG4221	oxidoreductase activity
GWK28_15780	COG0440	acetolactate synthase activity
GWK28_15785	COG0028	Belongs to the TPP enzyme family
GWK28_15810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_15815	COG0577	efflux transmembrane transporter activity
GWK28_15815	COG1136	(ABC) transporter
GWK28_15820	COG1538	Outer membrane efflux protein
GWK28_15835	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWK28_15840	COG1162	GTPase activity
GWK28_15850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWK28_15890	COG1426	Protein conserved in bacteria
GWK28_15925	COG0793	Belongs to the peptidase S41A family
GWK28_15940	COG2267	carboxylic ester hydrolase activity
GWK28_15950	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_15955	COG3265	gluconokinase activity
GWK28_15965	COG0800	Aldolase
GWK28_15975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWK28_15980	COG0857	belongs to the CobB CobQ family
GWK28_15980	COG0280	phosphate acetyltransferase
GWK28_15985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK28_15985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK28_16005	COG0740	serine-type endopeptidase activity
GWK28_16015	COG4774	siderophore transport
GWK28_16025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK28_16035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK28_16035	COG2813	Specifically methylates the guanine in position
GWK28_16185	COG0788	formyltetrahydrofolate deformylase activity
GWK28_16210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK28_16210	COG4651	solute:proton antiporter activity
GWK28_16230	COG0724	RNA recognition motif
GWK28_16235	COG0210	DNA helicase
GWK28_16260	COG1733	regulation of RNA biosynthetic process
GWK28_16270	COG2900	Belongs to the SlyX family
GWK28_16275	COG0488	(ABC) transporter
GWK28_16290	COG1560	Kdo2-lipid A biosynthetic process
GWK28_16300	COG1301	dicarboxylic acid transport
GWK28_16355	COG0473	3-isopropylmalate dehydrogenase activity
GWK28_16410	COG0583	DNA-binding transcription factor activity
GWK28_16420	COG0625	glutathione transferase activity
GWK28_16425	COG2378	regulation of single-species biofilm formation
GWK28_16430	COG0546	phosphoglycolate phosphatase activity
GWK28_16440	COG1530	ribonuclease E activity
GWK28_16445	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_16460	COG0583	DNA-binding transcription factor activity
GWK28_16465	COG4221	oxidoreductase activity
GWK28_16470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWK28_16480	COG0534	Mate efflux family protein
GWK28_16495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWK28_16585	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWK28_16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_16605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWK28_16615	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GWK28_16615	COG0644	oxidoreductase
GWK28_16625	COG0425	Belongs to the sulfur carrier protein TusA family
GWK28_16630	COG4535	Mg2 and Co2 transporter CorC
GWK28_16640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK28_16660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWK28_16665	COG0475	glutathione-regulated potassium exporter activity
GWK28_16665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK28_16680	COG0484	heat shock protein binding
GWK28_16685	COG0789	Transcriptional regulator
GWK28_16690	COG0598	Magnesium transport protein CorA
GWK28_16710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK28_16715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK28_16720	COG1074	ATP-dependent DNA helicase activity
GWK28_16725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWK28_16745	COG2226	methyltransferase
GWK28_16760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_16775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWK28_16790	COG2111	Na H antiporter
GWK28_16790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK28_16795	COG1006	Multisubunit Na H antiporter MnhC subunit
GWK28_16800	COG0651	ATP synthesis coupled electron transport
GWK28_16805	COG1863	multisubunit Na H antiporter MnhE subunit
GWK28_16810	COG2212	antiporter activity
GWK28_16815	COG1320	monovalent cation:proton antiporter activity
GWK28_16830	COG0195	Participates in both transcription termination and antitermination
GWK28_16880	COG0237	dephospho-CoA kinase activity
GWK28_16890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK28_16905	COG0497	DNA recombination
GWK28_16915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWK28_16945	COG2169	Transcriptional regulator
GWK28_16945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK28_16950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWK28_17015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWK28_17030	COG0326	Molecular chaperone. Has ATPase activity
GWK28_17045	COG2056	Na+-H+ antiporter family
GWK28_17145	COG0546	phosphoglycolate phosphatase activity
GWK28_17150	COG1716	ATPase activity
GWK28_17195	COG0181	hydroxymethylbilane synthase activity
GWK28_17205	COG3275	phosphorelay sensor kinase activity
GWK28_17225	COG1538	Outer membrane efflux protein
GWK28_17230	COG0697	spore germination
GWK28_17255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWK28_17260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK28_17265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK28_17270	COG0772	Belongs to the SEDS family
GWK28_17295	COG4974	Belongs to the 'phage' integrase family
GWK28_17300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK28_17310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK28_17320	COG2197	response regulator
GWK28_17335	COG0793	Belongs to the peptidase S41A family
GWK28_17340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWK28_17345	COG0795	lipopolysaccharide-transporting ATPase activity
GWK28_17385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK28_17385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK28_17395	COG0004	ammonium transporteR
GWK28_17400	COG0347	Belongs to the P(II) protein family
GWK28_17410	COG0606	chelatase, subunit chli
GWK28_17415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_17425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_17440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWK28_17455	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_17465	COG0477	Major facilitator Superfamily
GWK28_17470	COG2860	membrane
GWK28_17480	COG1253	flavin adenine dinucleotide binding
GWK28_17490	COG0477	Major facilitator Superfamily
GWK28_17500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK28_17505	COG0745	RESPONSE REGULATOR receiver
GWK28_17510	COG2205	protein histidine kinase activity
GWK28_17515	COG4452	Inner membrane protein CreD
GWK28_17555	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWK28_17565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK28_17600	COG1309	transcriptional regulator
GWK28_17635	COG0758	DNA mediated transformation
GWK28_17645	COG0697	spore germination
GWK28_17650	COG1309	transcriptional regulator
GWK28_17670	COG0386	Belongs to the glutathione peroxidase family
GWK28_17735	COG1121	(ABC) transporter
GWK28_17740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK28_17745	COG1280	lysine exporter protein (LysE YggA)
GWK28_17750	COG2837	iron assimilation
GWK28_17755	COG0281	malic enzyme
GWK28_17800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK28_17800	COG0519	Catalyzes the synthesis of GMP from XMP
GWK28_17805	COG4399	Belongs to the UPF0754 family
GWK28_17810	COG2259	Doxx family
GWK28_17815	COG0586	Pfam SNARE associated Golgi protein
GWK28_17830	COG1192	Involved in chromosome partitioning
GWK28_17840	COG0271	Belongs to the BolA IbaG family
GWK28_17880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK28_17880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWK28_17880	COG3321	synthase
GWK28_17880	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GWK28_17885	COG1960	acyl-CoA dehydrogenase activity
GWK28_17895	COG2197	response regulator
GWK28_17905	COG3916	Acyl-homoserine-lactone synthase
GWK28_17910	COG0477	Major facilitator Superfamily
GWK28_17915	COG1024	Enoyl-CoA hydratase
GWK28_17920	COG1024	Enoyl-CoA hydratase
GWK28_17925	COG1960	acyl-CoA dehydrogenase activity
GWK28_17930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK28_17950	COG1113	amino acid transport
GWK28_17955	COG1113	amino acid transport
GWK28_17960	COG0251	oxidation-reduction process
GWK28_18000	COG0564	pseudouridine synthase activity
GWK28_18085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWK28_18100	COG1802	Transcriptional regulator
GWK28_18110	COG1448	Aminotransferase
GWK28_18115	COG0277	FAD linked oxidase domain protein
GWK28_18125	COG2186	Transcriptional regulator
GWK28_18135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK28_18145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK28_18160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK28_18165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK28_18170	COG1216	Glycosyl transferase, family 2
GWK28_18180	COG1215	transferase activity, transferring glycosyl groups
GWK28_18190	COG0463	Glycosyl transferase, family 2
GWK28_18190	COG1216	Glycosyl transferase, family 2
GWK28_18210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWK28_18220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWK28_18225	COG1596	polysaccharide export
GWK28_18250	COG0728	peptidoglycan biosynthetic process
GWK28_18255	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWK28_18315	COG0546	phosphoglycolate phosphatase activity
GWK28_18320	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_18340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK28_18345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK28_18350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK28_18355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK28_18360	COG1116	anion transmembrane transporter activity
GWK28_18365	COG1309	transcriptional regulator
GWK28_18370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWK28_18380	COG0196	riboflavin kinase activity
GWK28_18385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK28_18395	COG1047	Peptidyl-prolyl cis-trans
GWK28_18435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWK28_18440	COG0657	acetylesterase activity
GWK28_18490	COG2951	lytic endotransglycosylase activity
GWK28_18495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWK28_18510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWK28_18520	COG0671	phosphoesterase, PA-phosphatase related
GWK28_18525	COG0861	Integral membrane protein TerC family
GWK28_18535	COG0754	glutathionylspermidine amidase activity
GWK28_18545	COG0402	S-adenosylhomocysteine deaminase activity
GWK28_18560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK28_18565	COG1230	cation diffusion facilitator family transporter
GWK28_18580	COG0706	membrane insertase activity
GWK28_18645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK28_18650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK28_18650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWK28_18700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK28_18700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK28_18715	COG0587	DNA-directed DNA polymerase activity
GWK28_18760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWK28_18820	COG0358	DNA primase activity
GWK28_18945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK28_18965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK28_19060	COG3586	endonuclease activity
GWK28_19195	COG3328	transposase activity
GWK28_19280	COG0582	viral genome integration into host DNA
GWK28_19310	COG1660	Displays ATPase and GTPase activities
GWK28_19360	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK28_19365	COG3657	addiction module killer protein
GWK28_19370	COG2826	transposase and inactivated derivatives, IS30 family
GWK28_19395	COG1324	tolerance protein
GWK28_19400	COG0673	inositol 2-dehydrogenase activity
GWK28_19420	COG2826	transposase and inactivated derivatives, IS30 family
GWK28_19465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK28_19485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWK28_19505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_19515	COG5002	protein histidine kinase activity
GWK28_19520	COG0745	RESPONSE REGULATOR receiver
GWK28_19535	COG0488	(ABC) transporter
GWK28_19540	COG3173	Aminoglycoside phosphotransferase
GWK28_19590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWK28_19595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWK28_19610	COG0789	Transcriptional regulator
GWK28_19665	COG3328	transposase activity