locus-tag	class	description
KU228_00010	COG0592	DNA-directed DNA polymerase activity
KU228_00020	COG0187	DNA topoisomerase II activity
KU228_00030	COG0586	Pfam SNARE associated Golgi protein
KU228_00035	COG0488	(ABC) transporter
KU228_00060	COG0596	Alpha beta hydrolase
KU228_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KU228_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KU228_00110	COG0733	neurotransmitter:sodium symporter activity
KU228_00150	COG2233	PERMEase
KU228_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU228_00200	COG2814	Major facilitator Superfamily
KU228_00205	COG0656	L-ascorbic acid biosynthetic process
KU228_00210	COG0583	DNA-binding transcription factor activity
KU228_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU228_00230	COG1064	alcohol dehydrogenase
KU228_00235	COG2818	Glycosylase
KU228_00250	COG1194	a g-specific adenine glycosylase
KU228_00270	COG2983	Belongs to the UPF0260 family
KU228_00275	COG2133	pyrroloquinoline quinone binding
KU228_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KU228_00285	COG2116	formate transmembrane transporter activity
KU228_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU228_00310	COG1335	isochorismatase
KU228_00315	COG0385	Bile acid
KU228_00320	COG0534	Mate efflux family protein
KU228_00325	COG1683	Conserved Protein
KU228_00345	COG0625	glutathione transferase activity
KU228_00355	COG1113	amino acid transport
KU228_00365	COG0523	cobalamin synthesis protein
KU228_00375	COG2188	Transcriptional regulator
KU228_00405	COG0010	Belongs to the arginase family
KU228_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KU228_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KU228_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KU228_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KU228_00540	COG0534	Mate efflux family protein
KU228_00545	COG0436	Aminotransferase
KU228_00550	COG2733	membrane
KU228_00565	COG2918	glutathione biosynthetic process
KU228_00580	COG1388	LysM domain
KU228_00580	COG0791	NLP P60 protein
KU228_00595	COG3150	esterase
KU228_00605	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KU228_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU228_00630	COG2233	PERMEase
KU228_00635	COG2351	hydroxyisourate hydrolase activity
KU228_00670	COG3706	GGDEF domain
KU228_00685	COG1393	Belongs to the ArsC family
KU228_00690	COG0708	Exodeoxyribonuclease III
KU228_00710	COG0189	ligase activity
KU228_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KU228_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KU228_00755	COG4942	peptidase
KU228_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU228_00775	COG2119	membrane
KU228_00780	COG4774	siderophore transport
KU228_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU228_00785	COG0426	domain, Protein
KU228_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KU228_00830	COG1902	pentaerythritol trinitrate reductase activity
KU228_00835	COG1519	Transferase
KU228_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU228_00845	COG0668	transmembrane transport
KU228_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU228_00860	COG1335	isochorismatase
KU228_00865	COG1522	sequence-specific DNA binding
KU228_00870	COG3328	transposase activity
KU228_00895	COG0784	Response regulator, receiver
KU228_00895	COG2198	Histidine kinase
KU228_00895	COG2205	protein histidine kinase activity
KU228_00900	COG3162	membrane
KU228_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU228_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU228_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KU228_00940	COG1309	transcriptional regulator
KU228_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KU228_00960	COG0352	thiamine-phosphate diphosphorylase activity
KU228_00960	COG0351	phosphomethylpyrimidine kinase
KU228_00970	COG2814	Major facilitator Superfamily
KU228_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KU228_00995	COG1113	amino acid transport
KU228_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KU228_01010	COG1012	belongs to the aldehyde dehydrogenase family
KU228_01020	COG1335	isochorismatase
KU228_01050	COG2814	Major facilitator Superfamily
KU228_01055	COG0583	DNA-binding transcription factor activity
KU228_01075	COG0667	Aldo Keto reductase
KU228_01110	COG1733	regulation of RNA biosynthetic process
KU228_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU228_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KU228_01195	COG2329	Antibiotic biosynthesis monooxygenase
KU228_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KU228_01255	COG0427	acetyl-CoA hydrolase
KU228_01280	COG0659	secondary active sulfate transmembrane transporter activity
KU228_01285	COG4221	oxidoreductase activity
KU228_01290	COG2873	o-acetylhomoserine
KU228_01295	COG0488	(ABC) transporter
KU228_01380	COG0833	amino acid
KU228_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KU228_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KU228_01445	COG2226	methyltransferase
KU228_01495	COG0067	glutamate synthase
KU228_01495	COG0069	glutamate synthase activity
KU228_01495	COG0070	glutamate synthase
KU228_01500	COG0493	'glutamate synthase
KU228_01510	COG1704	LemA family
KU228_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KU228_01535	COG3307	-O-antigen
KU228_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU228_01570	COG0194	GDP metabolic process
KU228_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KU228_01640	COG5380	lipid catabolic process
KU228_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KU228_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KU228_01675	COG0277	FAD linked oxidase domain protein
KU228_01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KU228_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU228_01705	COG1289	transmembrane transporter activity
KU228_01715	COG0628	permease
KU228_01720	COG1192	Involved in chromosome partitioning
KU228_01750	COG0833	amino acid
KU228_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU228_01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KU228_01770	COG1012	belongs to the aldehyde dehydrogenase family
KU228_01810	COG0583	DNA-binding transcription factor activity
KU228_01855	COG0517	IMP dehydrogenase activity
KU228_01860	COG1983	PspC domain protein
KU228_01870	COG1960	acyl-CoA dehydrogenase activity
KU228_01885	COG0408	coproporphyrinogen oxidase activity
KU228_01905	COG0513	Belongs to the DEAD box helicase family
KU228_01915	COG1127	ABC transporter
KU228_01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KU228_01930	COG2854	intermembrane phospholipid transfer
KU228_01940	COG0598	Magnesium transport protein CorA
KU228_01950	COG0494	nUDIX hydrolase
KU228_01955	COG1040	competence protein
KU228_01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KU228_01980	COG1946	Acyl-CoA thioesterase
KU228_01985	COG1301	dicarboxylic acid transport
KU228_02000	COG1959	2 iron, 2 sulfur cluster binding
KU228_02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU228_02005	COG1017	nitric oxide dioxygenase activity
KU228_02010	COG0433	COG0433 Predicted ATPase
KU228_02015	COG0626	cystathionine gamma-synthase activity
KU228_02170	COG1960	acyl-CoA dehydrogenase activity
KU228_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KU228_02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KU228_02210	COG0339	signal peptide processing
KU228_02215	COG0557	exoribonuclease II activity
KU228_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
KU228_02265	COG2169	Transcriptional regulator
KU228_02270	COG0697	spore germination
KU228_02275	COG1295	ribonuclease BN
KU228_02310	COG1702	phosphate starvation-inducible protein PhoH
KU228_02320	COG0741	lytic transglycosylase activity
KU228_02320	COG1196	nuclear chromosome segregation
KU228_02320	COG0739	heme binding
KU228_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KU228_02355	COG1183	phosphatidylcholine synthase activity
KU228_02400	COG1960	acyl-CoA dehydrogenase activity
KU228_02405	COG1309	transcriptional regulator
KU228_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KU228_02425	COG1960	acyl-CoA dehydrogenase activity
KU228_02445	COG2969	positive regulation of protein catabolic process
KU228_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KU228_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KU228_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KU228_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KU228_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU228_02510	COG1408	metallophosphoesterase
KU228_02520	COG2199	diguanylate cyclase activity
KU228_02580	COG1607	acyl-coa hydrolase
KU228_02610	COG2350	Protein conserved in bacteria
KU228_02620	COG0613	PHP domain protein
KU228_02625	COG3781	membrane
KU228_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KU228_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KU228_02650	COG1862	Preprotein translocase
KU228_02680	COG2205	protein histidine kinase activity
KU228_02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KU228_02705	COG0726	polysaccharide deacetylase
KU228_02710	COG0463	Glycosyl transferase, family 2
KU228_02715	COG0438	transferase activity, transferring glycosyl groups
KU228_02780	COG0625	glutathione transferase activity
KU228_02785	COG0583	DNA-binding transcription factor activity
KU228_02790	COG1960	acyl-CoA dehydrogenase activity
KU228_02795	COG1960	acyl-CoA dehydrogenase activity
KU228_02805	COG2205	protein histidine kinase activity
KU228_02810	COG0745	RESPONSE REGULATOR receiver
KU228_02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KU228_02835	COG2096	Adenosyltransferase
KU228_02885	COG0285	dihydrofolate synthase activity
KU228_02905	COG0450	alkyl hydroperoxide reductase
KU228_02920	COG0477	Major facilitator Superfamily
KU228_02925	COG1272	protein, Hemolysin III
KU228_02955	COG0183	Belongs to the thiolase family
KU228_02960	COG2207	Transcriptional regulator
KU228_02980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU228_03000	COG0183	Belongs to the thiolase family
KU228_03010	COG2885	chlorophyll binding
KU228_03010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KU228_03020	COG1690	Belongs to the RtcB family
KU228_03025	COG0833	amino acid
KU228_03035	COG2233	PERMEase
KU228_03040	COG1217	gtp-binding protein TYPA
KU228_03065	COG2094	Belongs to the DNA glycosylase MPG family
KU228_03070	COG4772	TonB-dependent receptor
KU228_03085	COG1902	pentaerythritol trinitrate reductase activity
KU228_03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU228_03105	COG0354	folic acid binding
KU228_03115	COG3189	MarR family transcriptional regulator
KU228_03120	COG2824	Alkylphosphonate utilization operon protein PhnA
KU228_03125	COG3422	double-strand break repair
KU228_03165	COG0840	transmembrane signaling receptor activity
KU228_03185	COG5510	response to toxic substance
KU228_03195	COG2832	Protein of unknown function (DUF454)
KU228_03200	COG1376	ErfK ybiS ycfS ynhG family protein
KU228_03240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KU228_03250	COG1289	transmembrane transporter activity
KU228_03255	COG2814	Major facilitator Superfamily
KU228_03275	COG1115	amino acid carrier protein
KU228_03280	COG1752	Esterase of the alpha-beta hydrolase superfamily
KU228_03285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KU228_03290	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KU228_03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU228_03340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU228_03345	COG1077	Cell shape determining protein MreB Mrl
KU228_03350	COG1792	Involved in formation and maintenance of cell shape
KU228_03355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KU228_03360	COG0424	maF-like protein
KU228_03365	COG1530	ribonuclease E activity
KU228_03375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU228_03385	COG0560	Phosphoserine phosphatase
KU228_03395	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU228_03420	COG2207	Transcriptional regulator
KU228_03440	COG1113	amino acid transport
KU228_03445	COG2828	Protein conserved in bacteria
KU228_03450	COG0142	geranyltranstransferase activity
KU228_03455	COG2315	Protein conserved in bacteria
KU228_03470	COG1752	Esterase of the alpha-beta hydrolase superfamily
KU228_03490	COG2194	sulfuric ester hydrolase activity
KU228_03495	COG0745	RESPONSE REGULATOR receiver
KU228_03500	COG0642	Histidine kinase
KU228_03510	COG0004	ammonium transporteR
KU228_03515	COG0583	DNA-binding transcription factor activity
KU228_03535	COG0525	valine-tRNA ligase activity
KU228_03545	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_03555	COG0393	Putative heavy-metal-binding
KU228_03560	COG0393	Putative heavy-metal-binding
KU228_03565	COG1538	Outer membrane efflux protein
KU228_03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU228_03580	COG0671	phosphoesterase, PA-phosphatase related
KU228_03610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KU228_03625	COG1648	precorrin-2 dehydrogenase activity
KU228_03625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KU228_03630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KU228_03635	COG1733	regulation of RNA biosynthetic process
KU228_03645	COG0531	amino acid
KU228_03660	COG0321	lipoyl(octanoyl) transferase activity
KU228_03665	COG2921	Belongs to the UPF0250 family
KU228_03705	COG2009	succinate dehydrogenase
KU228_03710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KU228_03715	COG1053	succinate dehydrogenase
KU228_03720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KU228_03745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU228_03765	COG2354	Protein conserved in bacteria
KU228_03770	COG2321	neutral zinc metallopeptidase
KU228_03810	COG2843	Capsule synthesis protein
KU228_03825	COG0589	response to stress
KU228_03845	COG0505	Belongs to the CarA family
KU228_03870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU228_03875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KU228_03925	COG0477	Major facilitator Superfamily
KU228_03930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KU228_03945	COG1597	lipid kinase activity
KU228_03950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KU228_03980	COG0584	glycerophosphoryl diester phosphodiesterase
KU228_04000	COG0741	lytic transglycosylase activity
KU228_04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KU228_04035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU228_04060	COG0778	Nitroreductase
KU228_04075	COG1929	Belongs to the glycerate kinase type-1 family
KU228_04080	COG0243	molybdopterin cofactor binding
KU228_04085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KU228_04090	COG3339	Conserved Protein
KU228_04100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KU228_04115	COG1113	amino acid transport
KU228_04125	COG0019	diaminopimelate decarboxylase activity
KU228_04135	COG1280	lysine exporter protein (LysE YggA)
KU228_04140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KU228_04170	COG0463	Glycosyl transferase, family 2
KU228_04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU228_04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
KU228_04230	COG1136	(ABC) transporter
KU228_04235	COG0658	competence protein
KU228_04235	COG2333	competence protein COMEC
KU228_04245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KU228_04245	COG0616	signal peptide processing
KU228_04250	COG0596	Alpha beta hydrolase
KU228_04255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KU228_04265	COG0628	permease
KU228_04300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU228_04320	COG0823	Involved in the tonB-independent uptake of proteins
KU228_04340	COG0824	Thioesterase
KU228_04345	COG1473	amidohydrolase
KU228_04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KU228_04365	COG0047	phosphoribosylformylglycinamidine synthase activity
KU228_04370	COG2814	Major facilitator Superfamily
KU228_04380	COG1024	Enoyl-CoA hydratase
KU228_04385	COG1051	belongs to the nudix hydrolase family
KU228_04385	COG1056	cytidyltransferase-related domain
KU228_04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KU228_04410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KU228_04425	COG4625	pathogenesis
KU228_04430	COG0583	DNA-binding transcription factor activity
KU228_04435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KU228_04440	COG4208	sulfate ABC transporter
KU228_04445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KU228_04455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KU228_04460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KU228_04465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KU228_04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KU228_04500	COG0681	Belongs to the peptidase S26 family
KU228_04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KU228_04525	COG1381	Involved in DNA repair and RecF pathway recombination
KU228_04530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KU228_04540	COG4221	oxidoreductase activity
KU228_04570	COG0436	Aminotransferase
KU228_04590	COG0556	nucleotide-excision repair
KU228_04645	COG2070	2-Nitropropane dioxygenase
KU228_04675	COG1215	transferase activity, transferring glycosyl groups
KU228_04690	COG0415	Belongs to the DNA photolyase family
KU228_04700	COG1252	NADH dehydrogenase
KU228_04705	COG1686	Belongs to the peptidase S11 family
KU228_04720	COG1187	pseudouridine synthase activity
KU228_04745	COG0477	Major facilitator Superfamily
KU228_04750	COG0583	DNA-binding transcription factor activity
KU228_04755	COG1823	symporter activity
KU228_04765	COG0612	Peptidase, M16
KU228_04790	COG0352	thiamine-phosphate diphosphorylase activity
KU228_04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU228_04840	COG1309	transcriptional regulator
KU228_04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KU228_04855	COG0076	glutamate decarboxylase activity
KU228_04865	COG1522	sequence-specific DNA binding
KU228_04870	COG3961	Belongs to the TPP enzyme family
KU228_04875	COG1113	amino acid transport
KU228_04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KU228_04885	COG0573	inorganic phosphate transmembrane transporter activity
KU228_04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KU228_04900	COG0616	signal peptide processing
KU228_04910	COG3328	transposase activity
KU228_04940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KU228_04945	COG1686	Belongs to the peptidase S11 family
KU228_04970	COG0583	DNA-binding transcription factor activity
KU228_04975	COG1067	ATP-dependent peptidase activity
KU228_05020	COG1966	Carbon starvation protein
KU228_05025	COG2879	small protein
KU228_05055	COG2508	Transcriptional regulator
KU228_05055	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KU228_05075	COG1113	amino acid transport
KU228_05080	COG0583	DNA-binding transcription factor activity
KU228_05085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU228_05090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU228_05100	COG1012	belongs to the aldehyde dehydrogenase family
KU228_05105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU228_05110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU228_05110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KU228_05145	COG2814	Major facilitator Superfamily
KU228_05150	COG4948	Mandelate Racemase Muconate Lactonizing
KU228_05160	COG1309	transcriptional regulator
KU228_05180	COG1741	Belongs to the pirin family
KU228_05190	COG2964	Protein conserved in bacteria
KU228_05205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU228_05210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KU228_05215	COG4605	iron ion homeostasis
KU228_05220	COG4604	ABC transporter, ATP-binding protein
KU228_05225	COG4607	ABC-type enterochelin transport system periplasmic component
KU228_05230	COG4774	siderophore transport
KU228_05240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU228_05245	COG1021	2,3-dihydroxybenzoate-AMP ligase
KU228_05250	COG3433	isochorismatase activity
KU228_05250	COG1535	isochorismatase
KU228_05265	COG1132	(ABC) transporter
KU228_05270	COG1132	(ABC) transporter
KU228_05275	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KU228_05285	COG1169	isochorismate synthase
KU228_05300	COG3739	integral membrane protein
KU228_05325	COG0302	gtp cyclohydrolase
KU228_05335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KU228_05365	COG0308	aminopeptidase N
KU228_05370	COG0512	Glutamine amidotransferase of anthranilate synthase
KU228_05385	COG0174	glutamine synthetase
KU228_05395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KU228_05430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KU228_05435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KU228_05440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KU228_05460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU228_05465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KU228_05470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KU228_05485	COG1960	acyl-CoA dehydrogenase activity
KU228_05490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU228_05495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU228_05505	COG2223	nitrite transmembrane transporter activity
KU228_05515	COG0024	Methionine aminopeptidase
KU228_05520	COG0052	Belongs to the universal ribosomal protein uS2 family
KU228_05535	COG2207	Transcriptional regulator
KU228_05560	COG2951	lytic endotransglycosylase activity
KU228_05565	COG0772	Belongs to the SEDS family
KU228_05580	COG0842	Transport permease protein
KU228_05585	COG1131	(ABC) transporter
KU228_05630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU228_05645	COG4215	(ABC) transporter
KU228_05650	COG4160	amino acid transport
KU228_05655	COG4598	ABC transporter
KU228_05665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU228_05670	COG0826	peptidase U32
KU228_05675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU228_05690	COG1720	tRNA m6t6A37 methyltransferase activity
KU228_05700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KU228_05715	COG0642	Histidine kinase
KU228_05725	COG0494	nUDIX hydrolase
KU228_05735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KU228_05740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KU228_05745	COG3139	Protein of unknown function (DUF1315)
KU228_05750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KU228_05755	COG1301	dicarboxylic acid transport
KU228_05760	COG1960	acyl-CoA dehydrogenase activity
KU228_05765	COG2819	hydrolase of the alpha beta superfamily
KU228_05775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KU228_05785	COG2195	Cleaves the N-terminal amino acid of tripeptides
KU228_05790	COG1234	tRNA 3'-trailer cleavage
KU228_05820	COG2363	Small membrane protein
KU228_05840	COG0513	Belongs to the DEAD box helicase family
KU228_05850	COG0778	Nitroreductase
KU228_06195	COG1286	toxin biosynthetic process
KU228_06220	COG4783	chaperone-mediated protein folding
KU228_06225	COG1610	YqeY-like protein
KU228_06325	COG3111	PFAM Bacterial OB fold (BOF) protein
KU228_06355	COG1301	dicarboxylic acid transport
KU228_06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU228_06370	COG2011	ABC-type metal ion transport system permease component
KU228_06375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KU228_06380	COG1464	Belongs to the NlpA lipoprotein family
KU228_06385	COG0151	Belongs to the GarS family
KU228_06390	COG0138	bifunctional purine biosynthesis protein purh
KU228_06395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KU228_06425	COG2308	Evidence 4 Homologs of previously reported genes of
KU228_06435	COG1305	Transglutaminase-like
KU228_06445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KU228_06450	COG0305	Participates in initiation and elongation during chromosome replication
KU228_06475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KU228_06485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KU228_06490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KU228_06515	COG0726	polysaccharide deacetylase
KU228_06515	COG1649	PFAM Uncharacterised BCR, COG1649
KU228_06520	COG1215	transferase activity, transferring glycosyl groups
KU228_06525	COG3658	cytochrome
KU228_06535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU228_06550	COG0583	DNA-binding transcription factor activity
KU228_06570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU228_06575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU228_06590	COG1960	acyl-CoA dehydrogenase activity
KU228_06595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU228_06600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU228_06625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KU228_06630	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KU228_06640	COG2205	protein histidine kinase activity
KU228_06645	COG0745	RESPONSE REGULATOR receiver
KU228_06650	COG0174	glutamine synthetase
KU228_06670	COG0729	surface antigen
KU228_06695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU228_06700	COG2814	Major facilitator Superfamily
KU228_06715	COG0583	DNA-binding transcription factor activity
KU228_06730	COG1187	pseudouridine synthase activity
KU228_06750	COG0802	atpase or kinase
KU228_06755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KU228_06765	COG1923	regulation of RNA biosynthetic process
KU228_06770	COG0697	spore germination
KU228_06785	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU228_06795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU228_06800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU228_06800	COG0519	Catalyzes the synthesis of GMP from XMP
KU228_06805	COG4302	ethanolamine ammonia-lyase activity
KU228_06810	COG4303	Ethanolamine ammonia lyase large subunit
KU228_06815	COG0531	amino acid
KU228_06835	COG1454	alcohol dehydrogenase
KU228_06840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU228_06850	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KU228_06870	COG0308	aminopeptidase N
KU228_06900	COG1605	Chorismate mutase
KU228_06915	COG1309	transcriptional regulator
KU228_06925	COG0668	transmembrane transport
KU228_06960	COG4773	Receptor
KU228_06980	COG0488	(ABC) transporter
KU228_06985	COG0589	response to stress
KU228_07010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KU228_07020	COG3135	benzoate transporter
KU228_07025	COG1522	sequence-specific DNA binding
KU228_07035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KU228_07040	COG0583	DNA-binding transcription factor activity
KU228_07050	COG0183	Belongs to the thiolase family
KU228_07060	COG2030	dehydratase
KU228_07065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KU228_07080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KU228_07090	COG0824	Thioesterase
KU228_07095	COG1454	alcohol dehydrogenase
KU228_07105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KU228_07125	COG0069	glutamate synthase activity
KU228_07290	COG5410	chromosome segregation
KU228_07410	COG0739	heme binding
KU228_07475	COG2814	Major facilitator Superfamily
KU228_07490	COG0511	ligase activity, forming carbon-carbon bonds
KU228_07510	COG1116	anion transmembrane transporter activity
KU228_07510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU228_07515	COG0745	RESPONSE REGULATOR receiver
KU228_07525	COG2146	nitrite reductase [NAD(P)H] activity
KU228_07525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU228_07530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU228_07535	COG0243	molybdopterin cofactor binding
KU228_07545	COG0243	molybdopterin cofactor binding
KU228_07550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KU228_07565	COG0315	cyclic pyranopterin monophosphate synthase activity
KU228_07565	COG0521	Mo-molybdopterin cofactor biosynthetic process
KU228_07570	COG0303	'Molybdopterin
KU228_07580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU228_07585	COG0697	spore germination
KU228_07605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KU228_07610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU228_07665	COG2204	response regulator
KU228_07670	COG3852	Histidine kinase
KU228_07695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KU228_07700	COG0575	Belongs to the CDS family
KU228_07735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU228_07750	COG2137	regulation of response to DNA damage stimulus
KU228_07760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KU228_07765	COG1011	Hydrolase
KU228_07790	COG1522	sequence-specific DNA binding
KU228_07800	COG1113	amino acid transport
KU228_07815	COG0659	secondary active sulfate transmembrane transporter activity
KU228_07820	COG2135	peptidase activity
KU228_07835	COG5001	Diguanylate cyclase
KU228_07835	COG3300	MHYT domain
KU228_07855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KU228_07855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KU228_07855	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KU228_07860	COG1105	Belongs to the carbohydrate kinase PfkB family
KU228_07865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KU228_07865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KU228_07895	COG0024	Methionine aminopeptidase
KU228_07900	COG0583	DNA-binding transcription factor activity
KU228_07910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KU228_07915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KU228_07920	COG0517	IMP dehydrogenase activity
KU228_07920	COG0516	GMP reductase activity
KU228_07945	COG0552	protein localization to endoplasmic reticulum
KU228_07955	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KU228_07970	COG4890	Cyd operon protein YbgT
KU228_07975	COG1294	oxidase, subunit
KU228_07990	COG1585	Membrane protein implicated in regulation of membrane protease activity
KU228_08000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KU228_08005	COG4774	siderophore transport
KU228_08020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KU228_08025	COG0569	domain protein
KU228_08030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KU228_08060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KU228_08065	COG0542	response to heat
KU228_08090	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU228_08090	COG1902	pentaerythritol trinitrate reductase activity
KU228_08135	COG2323	membrane
KU228_08140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KU228_08150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU228_08155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU228_08160	COG0183	Belongs to the thiolase family
KU228_08165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KU228_08170	COG0596	Alpha beta hydrolase
KU228_08175	COG2271	Major facilitator Superfamily
KU228_08180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KU228_08185	COG3485	protocatechuate 3,4-dioxygenase
KU228_08190	COG3485	protocatechuate 3,4-dioxygenase
KU228_08195	COG0710	3-dehydroquinate dehydratase activity
KU228_08200	COG3420	alginic acid biosynthetic process
KU228_08205	COG3659	wide pore channel activity
KU228_08210	COG4993	Dehydrogenase
KU228_08220	COG2391	methyltransferase activity
KU228_08235	COG1414	Transcriptional regulator
KU228_08240	COG0583	DNA-binding transcription factor activity
KU228_08245	COG1960	acyl-CoA dehydrogenase activity
KU228_08270	COG2814	Major facilitator Superfamily
KU228_08280	COG0154	amidase activity
KU228_08300	COG4638	Rieske (2fe-2S)
KU228_08310	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_08320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU228_08330	COG3733	amine oxidase
KU228_08340	COG1012	belongs to the aldehyde dehydrogenase family
KU228_08350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU228_08355	COG0183	Belongs to the thiolase family
KU228_08360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU228_08365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU228_08375	COG4829	muconolactone delta-isomerase
KU228_08380	COG4948	Mandelate Racemase Muconate Lactonizing
KU228_08385	COG0583	DNA-binding transcription factor activity
KU228_08395	COG2186	Transcriptional regulator
KU228_08415	COG1012	belongs to the aldehyde dehydrogenase family
KU228_08435	COG1960	acyl-CoA dehydrogenase activity
KU228_08440	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_08445	COG3829	transcription factor binding
KU228_08455	COG3162	membrane
KU228_08470	COG1012	belongs to the aldehyde dehydrogenase family
KU228_08485	COG0753	catalase activity
KU228_08505	COG1846	Transcriptional regulator
KU228_08510	COG1902	pentaerythritol trinitrate reductase activity
KU228_08510	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU228_08520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KU228_08550	COG1309	transcriptional regulator
KU228_08560	COG1335	isochorismatase
KU228_08565	COG0583	DNA-binding transcription factor activity
KU228_08575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU228_08575	COG0475	glutathione-regulated potassium exporter activity
KU228_08585	COG1473	amidohydrolase
KU228_08595	COG2831	hemolysin activation secretion protein
KU228_08600	COG3210	domain, Protein
KU228_08630	COG2188	Transcriptional regulator
KU228_08645	COG0583	DNA-binding transcription factor activity
KU228_08675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KU228_08700	COG0745	RESPONSE REGULATOR receiver
KU228_08705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU228_08710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU228_08715	COG1538	Outer membrane efflux protein
KU228_08725	COG2072	flavoprotein involved in K transport
KU228_08745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU228_08765	COG3539	Fimbrial protein
KU228_08795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KU228_08805	COG0753	catalase activity
KU228_08820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU228_08890	COG1535	isochorismatase
KU228_08890	COG3433	isochorismatase activity
KU228_08895	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_08900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KU228_08905	COG4149	molybdate abc transporter
KU228_08910	COG0725	ABC transporter, periplasmic molybdate-binding protein
KU228_08920	COG4638	Rieske (2fe-2S)
KU228_08925	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KU228_08965	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_08980	COG2207	Transcriptional regulator
KU228_08990	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_08995	COG2610	gluconate transmembrane transporter activity
KU228_09005	COG0583	DNA-binding transcription factor activity
KU228_09015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU228_09020	COG2031	fatty acid transporter
KU228_09025	COG0183	Belongs to the thiolase family
KU228_09030	COG0583	DNA-binding transcription factor activity
KU228_09035	COG0583	DNA-binding transcription factor activity
KU228_09050	COG1027	Aspartate ammonia-lyase
KU228_09060	COG0477	Major facilitator Superfamily
KU228_09080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU228_09085	COG4521	taurine ABC transporter
KU228_09100	COG2188	Transcriptional regulator
KU228_09110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KU228_09115	COG1733	regulation of RNA biosynthetic process
KU228_09120	COG3708	Transcriptional regulator
KU228_09120	COG2207	Transcriptional regulator
KU228_09135	COG0730	response to heat
KU228_09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU228_09145	COG3453	Protein conserved in bacteria
KU228_09155	COG3781	membrane
KU228_09160	COG1063	alcohol dehydrogenase
KU228_09170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU228_09175	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU228_09180	COG0022	dehydrogenase e1 component
KU228_09185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KU228_09190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU228_09205	COG3706	GGDEF domain
KU228_09220	COG0133	tryptophan synthase activity
KU228_09230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU228_09265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KU228_09290	COG2226	methyltransferase
KU228_09345	COG0842	Transport permease protein
KU228_09350	COG0842	Transport permease protein
KU228_09355	COG1131	(ABC) transporter
KU228_09370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU228_09375	COG4773	Receptor
KU228_09395	COG0730	response to heat
KU228_09400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KU228_09420	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KU228_09435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KU228_09475	COG4264	IucA IucC family
KU228_09480	COG4264	IucA IucC family
KU228_09500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KU228_09515	COG1960	acyl-CoA dehydrogenase activity
KU228_09520	COG1960	acyl-CoA dehydrogenase activity
KU228_09525	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU228_09530	COG2207	Transcriptional regulator
KU228_09535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU228_09540	COG0776	regulation of translation
KU228_09565	COG0822	iron-sulfur transferase activity
KU228_09570	COG0316	Belongs to the HesB IscA family
KU228_09600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KU228_09620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KU228_09625	COG0702	epimerase
KU228_09660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KU228_09670	COG0339	signal peptide processing
KU228_09720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KU228_09725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KU228_09755	COG0776	regulation of translation
KU228_09820	COG0084	hydrolase, TatD family'
KU228_09840	COG1663	tetraacyldisaccharide 4'-kinase activity
KU228_09845	COG1132	(ABC) transporter
KU228_09855	COG0811	peptide transport
KU228_09860	COG1475	DNA binding
KU228_09865	COG1192	Involved in chromosome partitioning
KU228_09875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KU228_09890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU228_09895	COG0191	fructose-bisphosphate aldolase activity
KU228_09915	COG0424	maF-like protein
KU228_09920	COG2850	peptidyl-arginine hydroxylation
KU228_09930	COG0640	Transcriptional regulator
KU228_09945	COG3619	membrane
KU228_09950	COG3122	Protein conserved in bacteria
KU228_09955	COG1132	(ABC) transporter
KU228_09975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KU228_09980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU228_09990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KU228_09990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KU228_09990	COG0506	proline dehydrogenase activity
KU228_09995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KU228_10010	COG3698	Phosphodiester glycosidase
KU228_10020	COG2353	YceI-like domain
KU228_10030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KU228_10075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KU228_10075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KU228_10100	COG3539	Fimbrial protein
KU228_10105	COG3121	Chaperone
KU228_10130	COG0697	spore germination
KU228_10140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KU228_10150	COG0583	DNA-binding transcription factor activity
KU228_10170	COG1309	transcriptional regulator
KU228_10185	COG1522	sequence-specific DNA binding
KU228_10195	COG1126	abc transporter atp-binding protein
KU228_10200	COG0765	amino acid transport
KU228_10205	COG0765	amino acid transport
KU228_10235	COG1464	Belongs to the NlpA lipoprotein family
KU228_10245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KU228_10250	COG2011	ABC-type metal ion transport system permease component
KU228_10255	COG0012	GTP binding
KU228_10280	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KU228_10320	COG0386	Belongs to the glutathione peroxidase family
KU228_10330	COG0436	Aminotransferase
KU228_10370	COG3634	alkyl hydroperoxide reductase activity
KU228_10385	COG0583	DNA-binding transcription factor activity
KU228_10390	COG0798	PFAM Bile acid sodium symporter
KU228_10395	COG0640	Transcriptional regulator
KU228_10410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KU228_10420	COG0583	DNA-binding transcription factor activity
KU228_10430	COG1953	Uracil, thiamine, allantoin
KU228_10440	COG2175	clavaminate synthase activity
KU228_10445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU228_10450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KU228_10455	COG4521	taurine ABC transporter
KU228_10465	COG0477	Major facilitator Superfamily
KU228_10490	COG1271	oxidase subunit
KU228_10495	COG1294	oxidase, subunit
KU228_10505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU228_10525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KU228_10545	COG3052	prosthetic group binding
KU228_10550	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KU228_10560	COG2814	Major facilitator Superfamily
KU228_10580	COG1346	cytolysis
KU228_10590	COG0583	DNA-binding transcription factor activity
KU228_10595	COG0625	glutathione transferase activity
KU228_10600	COG0625	glutathione transferase activity
KU228_10605	COG0583	DNA-binding transcription factor activity
KU228_10620	COG1045	serine acetyltransferase
KU228_10625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU228_10630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KU228_10640	COG1280	lysine exporter protein (LysE YggA)
KU228_10655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU228_10660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU228_10665	COG1126	abc transporter atp-binding protein
KU228_10670	COG0765	amino acid transport
KU228_10675	COG0765	amino acid transport
KU228_10695	COG2205	protein histidine kinase activity
KU228_10695	COG0784	Response regulator, receiver
KU228_10715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KU228_10735	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_10785	COG0583	DNA-binding transcription factor activity
KU228_10805	COG0318	PFAM AMP-dependent synthetase and ligase
KU228_10810	COG1309	transcriptional regulator
KU228_10815	COG1960	acyl-CoA dehydrogenase activity
KU228_10820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KU228_10825	COG1024	Enoyl-CoA hydratase
KU228_10830	COG4770	biotin carboxylase activity
KU228_10840	COG0583	DNA-binding transcription factor activity
KU228_10855	COG1960	acyl-CoA dehydrogenase activity
KU228_10865	COG2814	Major facilitator Superfamily
KU228_10875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU228_10880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU228_10885	COG2814	Major facilitator Superfamily
KU228_10890	COG1960	acyl-CoA dehydrogenase activity
KU228_10895	COG1024	Enoyl-CoA hydratase
KU228_10900	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_10905	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU228_10910	COG0183	Belongs to the thiolase family
KU228_10920	COG2814	Major facilitator Superfamily
KU228_10930	COG1024	Enoyl-CoA hydratase
KU228_10945	COG1960	acyl-CoA dehydrogenase activity
KU228_10950	COG2814	Major facilitator Superfamily
KU228_10955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KU228_10960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KU228_10975	COG3842	ATPase activity
KU228_10980	COG1840	ABC-type Fe3 transport system, periplasmic component
KU228_10990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU228_10995	COG1414	Transcriptional regulator
KU228_11005	COG0583	DNA-binding transcription factor activity
KU228_11010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KU228_11015	COG1012	belongs to the aldehyde dehydrogenase family
KU228_11025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KU228_11035	COG1012	belongs to the aldehyde dehydrogenase family
KU228_11040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU228_11045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU228_11050	COG2267	carboxylic ester hydrolase activity
KU228_11070	COG3038	cytochrome b561
KU228_11075	COG0753	catalase activity
KU228_11110	COG2050	protein possibly involved in aromatic compounds catabolism
KU228_11120	COG3327	negative regulation of DNA-templated transcription, initiation
KU228_11125	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KU228_11130	COG0183	Belongs to the thiolase family
KU228_11135	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU228_11140	COG1024	Enoyl-CoA hydratase
KU228_11145	COG1024	Enoyl-CoA hydratase
KU228_11150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU228_11155	COG2151	metal-sulfur cluster biosynthetic enzyme
KU228_11160	COG3396	Phenylacetate-CoA oxygenase
KU228_11165	COG3460	Phenylacetate-CoA oxygenase
KU228_11170	COG3396	Phenylacetate-CoA oxygenase
KU228_11175	COG2030	dehydratase
KU228_11175	COG1012	belongs to the aldehyde dehydrogenase family
KU228_11180	COG1760	l-serine dehydratase
KU228_11185	COG0531	amino acid
KU228_11190	COG1012	belongs to the aldehyde dehydrogenase family
KU228_11205	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU228_11215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU228_11235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU228_11245	COG0789	Transcriptional regulator
KU228_11260	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KU228_11275	COG2807	transmembrane transport
KU228_11280	COG0590	tRNA wobble adenosine to inosine editing
KU228_11395	COG1116	anion transmembrane transporter activity
KU228_11400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU228_11410	COG0864	Transcriptional regulator
KU228_11430	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU228_11435	COG0439	Biotin carboxylase
KU228_11450	COG1063	alcohol dehydrogenase
KU228_11460	COG1309	transcriptional regulator
KU228_11480	COG0038	chloride channel
KU228_11485	COG4770	biotin carboxylase activity
KU228_11505	COG1914	H( )-stimulated, divalent metal cation uptake system
KU228_11510	COG0583	DNA-binding transcription factor activity
KU228_11560	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU228_11580	COG2814	Major facilitator Superfamily
KU228_11590	COG1560	Kdo2-lipid A biosynthetic process
KU228_11600	COG5006	permease, DMT superfamily
KU228_11605	COG1522	sequence-specific DNA binding
KU228_11620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KU228_11630	COG4122	O-methyltransferase activity
KU228_11660	COG1538	Outer membrane efflux protein
KU228_11665	COG1137	ATPase activity
KU228_11670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KU228_11680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KU228_11685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KU228_11685	COG0517	IMP dehydrogenase activity
KU228_11720	COG2814	Major facilitator Superfamily
KU228_11755	COG1278	Cold shock
KU228_11760	COG1280	lysine exporter protein (LysE YggA)
KU228_11790	COG1570	exodeoxyribonuclease VII activity
KU228_11840	COG0583	DNA-binding transcription factor activity
KU228_11845	COG4638	Rieske (2fe-2S)
KU228_11850	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KU228_11855	COG0633	Ferredoxin
KU228_11855	COG0543	2 iron, 2 sulfur cluster binding
KU228_11860	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_11865	COG3135	benzoate transporter
KU228_11870	COG2814	Major facilitator Superfamily
KU228_11885	COG1643	Atp-dependent helicase
KU228_11890	COG0450	alkyl hydroperoxide reductase
KU228_11900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KU228_11910	COG3634	alkyl hydroperoxide reductase activity
KU228_11930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KU228_11935	COG0625	glutathione transferase activity
KU228_11945	COG2885	chlorophyll binding
KU228_11980	COG0542	response to heat
KU228_11995	COG1765	OsmC-like protein
KU228_12015	COG0667	Aldo Keto reductase
KU228_12030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KU228_12040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KU228_12050	COG0527	aspartate kinase activity
KU228_12060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KU228_12070	COG3038	cytochrome b561
KU228_12075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KU228_12080	COG2252	PERMEase
KU228_12090	COG2072	flavoprotein involved in K transport
KU228_12105	COG1741	Belongs to the pirin family
KU228_12110	COG1309	transcriptional regulator
KU228_12135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KU228_12175	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU228_12175	COG1902	pentaerythritol trinitrate reductase activity
KU228_12185	COG4251	negative regulation of phosphorylation
KU228_12185	COG5001	Diguanylate cyclase
KU228_12185	COG3706	GGDEF domain
KU228_12185	COG2203	Gaf domain
KU228_12195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU228_12215	COG4172	Belongs to the ABC transporter superfamily
KU228_12220	COG4239	(ABC) transporter, permease
KU228_12225	COG4174	ABC transporter (Permease)
KU228_12235	COG0741	lytic transglycosylase activity
KU228_12235	COG1388	LysM domain
KU228_12235	COG0741	lytic transglycosylase activity
KU228_12235	COG1388	LysM domain
KU228_12240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU228_12280	COG0583	DNA-binding transcription factor activity
KU228_12285	COG1279	arginine transmembrane transporter activity
KU228_12305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU228_12310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU228_12315	COG0006	proline dipeptidase activity
KU228_12355	COG2194	sulfuric ester hydrolase activity
KU228_12400	COG0739	heme binding
KU228_12730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KU228_12755	COG3384	dioxygenase
KU228_12765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU228_12770	COG2878	Part of a membrane complex involved in electron transport
KU228_12775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KU228_12800	COG0768	penicillin binding
KU228_12805	COG0742	ribosomal rna small subunit methyltransferase
KU228_12820	COG0830	nickel cation binding
KU228_12865	COG1253	flavin adenine dinucleotide binding
KU228_12870	COG2851	Citrate transporter
KU228_12925	COG1773	rubredoxin
KU228_12930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU228_12940	COG0583	DNA-binding transcription factor activity
KU228_12965	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KU228_12970	COG4181	ATPase activity
KU228_13015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KU228_13035	COG0306	phosphate transporter
KU228_13045	COG3958	Transketolase
KU228_13050	COG3959	Transketolase, thiamine diphosphate binding domain
KU228_13055	COG2271	Major facilitator Superfamily
KU228_13060	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_13065	COG0583	DNA-binding transcription factor activity
KU228_13080	COG2223	nitrite transmembrane transporter activity
KU228_13085	COG2207	Transcriptional regulator
KU228_13090	COG2066	Belongs to the glutaminase family
KU228_13095	COG0242	peptide deformylase activity
KU228_13100	COG0477	Major facilitator Superfamily
KU228_13110	COG0028	Belongs to the TPP enzyme family
KU228_13125	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_13130	COG2267	carboxylic ester hydrolase activity
KU228_13140	COG2271	Major facilitator Superfamily
KU228_13145	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU228_13155	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_13175	COG1414	Transcriptional regulator
KU228_13190	COG1024	Enoyl-CoA hydratase
KU228_13200	COG1215	transferase activity, transferring glycosyl groups
KU228_13205	COG0726	polysaccharide deacetylase
KU228_13205	COG1649	PFAM Uncharacterised BCR, COG1649
KU228_13215	COG4681	YaeQ
KU228_13225	COG0523	cobalamin synthesis protein
KU228_13235	COG1607	acyl-coa hydrolase
KU228_13245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU228_13250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU228_13255	COG1309	transcriptional regulator
KU228_13280	COG2040	homocysteine
KU228_13285	COG0531	amino acid
KU228_13340	COG1595	DNA-templated transcription, initiation
KU228_13350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU228_13355	COG0477	Major facilitator Superfamily
KU228_13375	COG0084	hydrolase, TatD family'
KU228_13410	COG0629	single-stranded DNA binding
KU228_13465	COG0582	viral genome integration into host DNA
KU228_13565	COG0592	DNA-directed DNA polymerase activity
KU228_13605	COG2026	Addiction module toxin, RelE StbE family
KU228_13800	COG1484	DNA-dependent DNA replication
KU228_13890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU228_13960	COG0405	Gamma-glutamyltransferase
KU228_13965	COG2814	Major facilitator Superfamily
KU228_13975	COG2050	protein possibly involved in aromatic compounds catabolism
KU228_13990	COG1090	epimerase
KU228_14010	COG0420	3'-5' exonuclease activity
KU228_14035	COG0735	belongs to the Fur family
KU228_14040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KU228_14060	COG0121	glutamine amidotransferase
KU228_14075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU228_14085	COG0210	DNA helicase
KU228_14090	COG2885	chlorophyll binding
KU228_14095	COG0204	Acyl-transferase
KU228_14110	COG2894	cell division
KU228_14135	COG1280	lysine exporter protein (LysE YggA)
KU228_14140	COG1674	ftsk spoiiie
KU228_14140	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KU228_14145	COG0492	ferredoxin-NADP+ reductase activity
KU228_14150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KU228_14160	COG0456	acetyltransferase
KU228_14205	COG1981	membrane
KU228_14220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU228_14220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KU228_14240	COG1012	belongs to the aldehyde dehydrogenase family
KU228_14250	COG0657	acetylesterase activity
KU228_14260	COG0473	3-isopropylmalate dehydrogenase activity
KU228_14265	COG0583	DNA-binding transcription factor activity
KU228_14285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU228_14310	COG0564	pseudouridine synthase activity
KU228_14320	COG0358	DNA primase activity
KU228_14335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KU228_14365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KU228_14395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KU228_14405	COG0352	thiamine-phosphate diphosphorylase activity
KU228_14405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KU228_14405	COG0351	phosphomethylpyrimidine kinase
KU228_14410	COG1652	LysM domain
KU228_14435	COG1399	metal-binding, possibly nucleic acid-binding protein
KU228_14440	COG3101	peptidyl-lysine hydroxylation
KU228_14445	COG0009	L-threonylcarbamoyladenylate synthase
KU228_14450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KU228_14455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KU228_14470	COG4106	trans-aconitate 2-methyltransferase activity
KU228_14485	COG0596	Alpha beta hydrolase
KU228_14485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU228_14485	COG2226	methyltransferase
KU228_14490	COG1877	trehalose-phosphatase activity
KU228_14495	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KU228_14500	COG2223	nitrite transmembrane transporter activity
KU228_14520	COG1196	nuclear chromosome segregation
KU228_14530	COG0730	response to heat
KU228_14545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KU228_14555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU228_14605	COG0489	protein tyrosine kinase activity
KU228_14615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU228_14615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU228_14645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KU228_14650	COG2081	HI0933 family
KU228_14660	COG0668	transmembrane transport
KU228_14680	COG0583	DNA-binding transcription factor activity
KU228_14700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU228_14705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KU228_14735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KU228_14775	COG0745	RESPONSE REGULATOR receiver
KU228_14795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KU228_14805	COG2205	protein histidine kinase activity
KU228_14875	COG4993	Dehydrogenase
KU228_14900	COG0384	phenazine biosynthesis protein PhzF
KU228_14920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU228_14935	COG0583	DNA-binding transcription factor activity
KU228_14965	COG0583	DNA-binding transcription factor activity
KU228_14980	COG0583	DNA-binding transcription factor activity
KU228_14985	COG1053	succinate dehydrogenase
KU228_14995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KU228_15000	COG2814	Major facilitator Superfamily
KU228_15005	COG1960	acyl-CoA dehydrogenase activity
KU228_15010	COG0583	DNA-binding transcription factor activity
KU228_15015	COG1063	alcohol dehydrogenase
KU228_15045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KU228_15050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KU228_15055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU228_15070	COG3667	copper resistance
KU228_15075	COG2132	Multicopper oxidase
KU228_15085	COG0561	phosphatase activity
KU228_15090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KU228_15115	COG1214	PFAM Peptidase M22, glycoprotease
KU228_15170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KU228_15180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KU228_15185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KU228_15190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KU228_15250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU228_15260	COG1846	Transcriptional regulator
KU228_15265	COG1764	response to oxidative stress
KU228_15315	COG0037	tRNA processing
KU228_15325	COG0248	Ppx GppA phosphatase
KU228_15355	COG0072	phenylalanine-tRNA ligase activity
KU228_15395	COG1238	metal cluster binding
KU228_15400	COG0625	glutathione transferase activity
KU228_15415	COG0318	PFAM AMP-dependent synthetase and ligase
KU228_15420	COG3028	Belongs to the UPF0307 family
KU228_15425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KU228_15445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KU228_15450	COG0617	tRNA 3'-terminal CCA addition
KU228_15455	COG1555	photosystem II stabilization
KU228_15460	COG3956	TIGRFAM MazG family protein
KU228_15470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU228_15490	COG0784	Response regulator, receiver
KU228_15490	COG2205	protein histidine kinase activity
KU228_15490	COG5002	protein histidine kinase activity
KU228_15495	COG1024	Enoyl-CoA hydratase
KU228_15500	COG2084	Dehydrogenase
KU228_15505	COG3622	Belongs to the hyi family
KU228_15535	COG0697	spore germination
KU228_15545	COG2814	Major facilitator Superfamily
KU228_15550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU228_15560	COG0583	DNA-binding transcription factor activity
KU228_15570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KU228_15585	COG0084	hydrolase, TatD family'
KU228_15600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KU228_15630	COG0440	acetolactate synthase activity
KU228_15635	COG0028	Belongs to the TPP enzyme family
KU228_15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU228_15665	COG1136	(ABC) transporter
KU228_15665	COG0577	efflux transmembrane transporter activity
KU228_15670	COG1538	Outer membrane efflux protein
KU228_15685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KU228_15690	COG1162	GTPase activity
KU228_15700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KU228_15720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KU228_15725	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_15765	COG2986	histidine ammonia-lyase
KU228_15780	COG0318	PFAM AMP-dependent synthetase and ligase
KU228_15790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU228_15835	COG1426	Protein conserved in bacteria
KU228_15870	COG0793	Belongs to the peptidase S41A family
KU228_15885	COG2267	carboxylic ester hydrolase activity
KU228_15895	COG1012	belongs to the aldehyde dehydrogenase family
KU228_15900	COG3265	gluconokinase activity
KU228_15910	COG0800	Aldolase
KU228_15925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KU228_15930	COG0857	belongs to the CobB CobQ family
KU228_15930	COG0280	phosphate acetyltransferase
KU228_15935	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KU228_15935	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KU228_15955	COG0740	serine-type endopeptidase activity
KU228_15965	COG4774	siderophore transport
KU228_15975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KU228_15985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU228_15985	COG2813	Specifically methylates the guanine in position
KU228_16085	COG0788	formyltetrahydrofolate deformylase activity
KU228_16110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU228_16110	COG4651	solute:proton antiporter activity
KU228_16130	COG0724	RNA recognition motif
KU228_16135	COG0210	DNA helicase
KU228_16160	COG1733	regulation of RNA biosynthetic process
KU228_16170	COG2900	Belongs to the SlyX family
KU228_16175	COG0488	(ABC) transporter
KU228_16180	COG1280	lysine exporter protein (LysE YggA)
KU228_16185	COG1560	Kdo2-lipid A biosynthetic process
KU228_16195	COG1301	dicarboxylic acid transport
KU228_16250	COG0473	3-isopropylmalate dehydrogenase activity
KU228_16315	COG0583	DNA-binding transcription factor activity
KU228_16325	COG0625	glutathione transferase activity
KU228_16330	COG2378	regulation of single-species biofilm formation
KU228_16335	COG0546	phosphoglycolate phosphatase activity
KU228_16345	COG1530	ribonuclease E activity
KU228_16350	COG0318	PFAM AMP-dependent synthetase and ligase
KU228_16365	COG0583	DNA-binding transcription factor activity
KU228_16370	COG4221	oxidoreductase activity
KU228_16375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KU228_16385	COG0534	Mate efflux family protein
KU228_16400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KU228_16440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KU228_16445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU228_16460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KU228_16470	COG0644	oxidoreductase
KU228_16470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KU228_16475	COG0425	Belongs to the sulfur carrier protein TusA family
KU228_16480	COG4535	Mg2 and Co2 transporter CorC
KU228_16490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU228_16510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KU228_16515	COG0475	glutathione-regulated potassium exporter activity
KU228_16515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU228_16520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KU228_16530	COG0484	heat shock protein binding
KU228_16535	COG0789	Transcriptional regulator
KU228_16540	COG0598	Magnesium transport protein CorA
KU228_16555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KU228_16560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU228_16565	COG1074	ATP-dependent DNA helicase activity
KU228_16570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KU228_16590	COG2226	methyltransferase
KU228_16605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU228_16610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KU228_16625	COG2111	Na H antiporter
KU228_16625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KU228_16630	COG1006	Multisubunit Na H antiporter MnhC subunit
KU228_16635	COG0651	ATP synthesis coupled electron transport
KU228_16640	COG1863	multisubunit Na H antiporter MnhE subunit
KU228_16645	COG2212	antiporter activity
KU228_16650	COG1320	monovalent cation:proton antiporter activity
KU228_16665	COG0195	Participates in both transcription termination and antitermination
KU228_16715	COG0237	dephospho-CoA kinase activity
KU228_16725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU228_16740	COG0497	DNA recombination
KU228_16750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KU228_16780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU228_16780	COG2169	Transcriptional regulator
KU228_16785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KU228_16850	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KU228_16865	COG0326	Molecular chaperone. Has ATPase activity
KU228_16880	COG2056	Na+-H+ antiporter family
KU228_16885	COG0596	Alpha beta hydrolase
KU228_16980	COG0546	phosphoglycolate phosphatase activity
KU228_16985	COG1716	ATPase activity
KU228_17030	COG0181	hydroxymethylbilane synthase activity
KU228_17040	COG3275	phosphorelay sensor kinase activity
KU228_17060	COG1538	Outer membrane efflux protein
KU228_17065	COG0697	spore germination
KU228_17090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KU228_17095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KU228_17100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU228_17105	COG0772	Belongs to the SEDS family
KU228_17130	COG4974	Belongs to the 'phage' integrase family
KU228_17135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU228_17145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KU228_17155	COG2197	response regulator
KU228_17170	COG0793	Belongs to the peptidase S41A family
KU228_17175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KU228_17180	COG0795	lipopolysaccharide-transporting ATPase activity
KU228_17220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU228_17220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU228_17230	COG0004	ammonium transporteR
KU228_17235	COG0347	Belongs to the P(II) protein family
KU228_17245	COG0606	chelatase, subunit chli
KU228_17325	COG0659	secondary active sulfate transmembrane transporter activity
KU228_17330	COG0589	response to stress
KU228_17370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU228_17415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KU228_17475	COG0659	secondary active sulfate transmembrane transporter activity
KU228_17480	COG0589	response to stress
KU228_17510	COG0606	chelatase, subunit chli
KU228_17525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU228_17540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KU228_17555	COG0318	PFAM AMP-dependent synthetase and ligase
KU228_17565	COG0477	Major facilitator Superfamily
KU228_17570	COG2860	membrane
KU228_17580	COG1253	flavin adenine dinucleotide binding
KU228_17600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KU228_17635	COG0655	NAD(P)H dehydrogenase (quinone) activity
KU228_17645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KU228_17680	COG1309	transcriptional regulator
KU228_17715	COG0758	DNA mediated transformation
KU228_17725	COG0697	spore germination
KU228_17730	COG1309	transcriptional regulator
KU228_17745	COG0386	Belongs to the glutathione peroxidase family
KU228_17810	COG1121	(ABC) transporter
KU228_17815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KU228_17820	COG1280	lysine exporter protein (LysE YggA)
KU228_17825	COG2837	iron assimilation
KU228_17835	COG0281	malic enzyme
KU228_17880	COG0519	Catalyzes the synthesis of GMP from XMP
KU228_17880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU228_17885	COG4399	Belongs to the UPF0754 family
KU228_17890	COG2259	Doxx family
KU228_17895	COG0586	Pfam SNARE associated Golgi protein
KU228_17910	COG1192	Involved in chromosome partitioning
KU228_17920	COG0271	Belongs to the BolA IbaG family
KU228_17940	COG2267	carboxylic ester hydrolase activity
KU228_17960	COG3321	synthase
KU228_17960	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KU228_17960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KU228_17960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU228_17965	COG1960	acyl-CoA dehydrogenase activity
KU228_17975	COG2197	response regulator
KU228_17985	COG3916	Acyl-homoserine-lactone synthase
KU228_17990	COG0477	Major facilitator Superfamily
KU228_17995	COG1024	Enoyl-CoA hydratase
KU228_18000	COG1024	Enoyl-CoA hydratase
KU228_18005	COG1960	acyl-CoA dehydrogenase activity
KU228_18010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU228_18030	COG1113	amino acid transport
KU228_18035	COG1113	amino acid transport
KU228_18040	COG0251	oxidation-reduction process
KU228_18080	COG0564	pseudouridine synthase activity
KU228_18140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KU228_18155	COG1802	Transcriptional regulator
KU228_18165	COG1448	Aminotransferase
KU228_18170	COG0277	FAD linked oxidase domain protein
KU228_18180	COG2186	Transcriptional regulator
KU228_18190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU228_18195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU228_18210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KU228_18215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KU228_18220	COG1216	Glycosyl transferase, family 2
KU228_18250	COG2089	acid synthase
KU228_18265	COG1083	cytidylyl-transferase
KU228_18270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KU228_18275	COG1086	Polysaccharide biosynthesis protein
KU228_18280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KU228_18285	COG1596	polysaccharide export
KU228_18310	COG0728	peptidoglycan biosynthetic process
KU228_18315	COG3023	N-Acetylmuramoyl-L-alanine amidase
KU228_18370	COG0546	phosphoglycolate phosphatase activity
KU228_18375	COG1028	Short-chain dehydrogenase reductase Sdr
KU228_18395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU228_18400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU228_18405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU228_18410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU228_18415	COG1116	anion transmembrane transporter activity
KU228_18420	COG1309	transcriptional regulator
KU228_18425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KU228_18435	COG0196	riboflavin kinase activity
KU228_18440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KU228_18450	COG1047	Peptidyl-prolyl cis-trans
KU228_18490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KU228_18495	COG0657	acetylesterase activity
KU228_18545	COG2951	lytic endotransglycosylase activity
KU228_18550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KU228_18565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KU228_18575	COG0671	phosphoesterase, PA-phosphatase related
KU228_18580	COG0861	Integral membrane protein TerC family
KU228_18590	COG0754	glutathionylspermidine amidase activity
KU228_18600	COG0402	S-adenosylhomocysteine deaminase activity
KU228_18615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU228_18620	COG1230	cation diffusion facilitator family transporter
KU228_18635	COG0706	membrane insertase activity
KU228_18705	COG1525	nuclease
KU228_18775	COG1475	DNA binding
KU228_18790	COG3853	Toxic anion resistance protein (TelA)
KU228_18970	COG0741	lytic transglycosylase activity
KU228_19005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process