locus-tag	class	description
KU224_00010	COG0592	DNA-directed DNA polymerase activity
KU224_00020	COG0187	DNA topoisomerase II activity
KU224_00030	COG0586	Pfam SNARE associated Golgi protein
KU224_00035	COG0488	(ABC) transporter
KU224_00060	COG0596	Alpha beta hydrolase
KU224_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KU224_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KU224_00160	COG2233	PERMEase
KU224_00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU224_00210	COG2814	Major facilitator Superfamily
KU224_00215	COG0656	L-ascorbic acid biosynthetic process
KU224_00220	COG0583	DNA-binding transcription factor activity
KU224_00235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU224_00240	COG1064	alcohol dehydrogenase
KU224_00245	COG2818	Glycosylase
KU224_00260	COG1194	a g-specific adenine glycosylase
KU224_00280	COG2983	Belongs to the UPF0260 family
KU224_00285	COG2133	pyrroloquinoline quinone binding
KU224_00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KU224_00295	COG2116	formate transmembrane transporter activity
KU224_00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU224_00320	COG1335	isochorismatase
KU224_00325	COG0385	Bile acid
KU224_00330	COG0534	Mate efflux family protein
KU224_00335	COG1683	Conserved Protein
KU224_00355	COG0625	glutathione transferase activity
KU224_00365	COG1113	amino acid transport
KU224_00375	COG0523	cobalamin synthesis protein
KU224_00385	COG2188	Transcriptional regulator
KU224_00415	COG0010	Belongs to the arginase family
KU224_00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KU224_00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KU224_00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KU224_00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KU224_00550	COG0534	Mate efflux family protein
KU224_00555	COG0436	Aminotransferase
KU224_00560	COG2733	membrane
KU224_00575	COG2918	glutathione biosynthetic process
KU224_00590	COG0791	NLP P60 protein
KU224_00590	COG1388	LysM domain
KU224_00605	COG3150	esterase
KU224_00615	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KU224_00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU224_00640	COG2233	PERMEase
KU224_00645	COG2351	hydroxyisourate hydrolase activity
KU224_00680	COG3706	GGDEF domain
KU224_00695	COG1393	Belongs to the ArsC family
KU224_00700	COG0708	Exodeoxyribonuclease III
KU224_00720	COG0189	ligase activity
KU224_00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KU224_00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KU224_00765	COG4942	peptidase
KU224_00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU224_00785	COG2119	membrane
KU224_00790	COG4774	siderophore transport
KU224_00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU224_00795	COG0426	domain, Protein
KU224_00820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KU224_00840	COG1902	pentaerythritol trinitrate reductase activity
KU224_00845	COG1519	Transferase
KU224_00850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU224_00855	COG0668	transmembrane transport
KU224_00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU224_00870	COG1335	isochorismatase
KU224_00875	COG1522	sequence-specific DNA binding
KU224_00880	COG3328	transposase activity
KU224_00905	COG0784	Response regulator, receiver
KU224_00905	COG2198	Histidine kinase
KU224_00905	COG2205	protein histidine kinase activity
KU224_00910	COG3162	membrane
KU224_00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU224_00925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU224_00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KU224_00950	COG1309	transcriptional regulator
KU224_00970	COG0351	phosphomethylpyrimidine kinase
KU224_00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KU224_00970	COG0352	thiamine-phosphate diphosphorylase activity
KU224_00980	COG2814	Major facilitator Superfamily
KU224_00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KU224_01005	COG1113	amino acid transport
KU224_01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KU224_01020	COG1012	belongs to the aldehyde dehydrogenase family
KU224_01030	COG1335	isochorismatase
KU224_01060	COG2814	Major facilitator Superfamily
KU224_01065	COG0583	DNA-binding transcription factor activity
KU224_01085	COG0667	Aldo Keto reductase
KU224_01120	COG1733	regulation of RNA biosynthetic process
KU224_01125	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU224_01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KU224_01205	COG2329	Antibiotic biosynthesis monooxygenase
KU224_01235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KU224_01265	COG0427	acetyl-CoA hydrolase
KU224_01290	COG0659	secondary active sulfate transmembrane transporter activity
KU224_01295	COG4221	oxidoreductase activity
KU224_01300	COG2873	o-acetylhomoserine
KU224_01305	COG0488	(ABC) transporter
KU224_01390	COG0833	amino acid
KU224_01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KU224_01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KU224_01455	COG2226	methyltransferase
KU224_01505	COG0069	glutamate synthase activity
KU224_01505	COG0070	glutamate synthase
KU224_01505	COG0067	glutamate synthase
KU224_01510	COG0493	'glutamate synthase
KU224_01520	COG1704	LemA family
KU224_01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KU224_01545	COG3307	-O-antigen
KU224_01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU224_01580	COG0194	GDP metabolic process
KU224_01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KU224_01650	COG5380	lipid catabolic process
KU224_01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KU224_01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KU224_01685	COG0277	FAD linked oxidase domain protein
KU224_01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KU224_01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU224_01715	COG1289	transmembrane transporter activity
KU224_01725	COG0628	permease
KU224_01730	COG1192	Involved in chromosome partitioning
KU224_01760	COG0833	amino acid
KU224_01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU224_01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KU224_01780	COG1012	belongs to the aldehyde dehydrogenase family
KU224_01820	COG0583	DNA-binding transcription factor activity
KU224_01865	COG0517	IMP dehydrogenase activity
KU224_01870	COG1983	PspC domain protein
KU224_01880	COG1960	acyl-CoA dehydrogenase activity
KU224_01895	COG0408	coproporphyrinogen oxidase activity
KU224_01915	COG0513	Belongs to the DEAD box helicase family
KU224_01925	COG1127	ABC transporter
KU224_01930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KU224_01940	COG2854	intermembrane phospholipid transfer
KU224_01950	COG0598	Magnesium transport protein CorA
KU224_01960	COG0494	nUDIX hydrolase
KU224_01965	COG1040	competence protein
KU224_01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KU224_01990	COG1946	Acyl-CoA thioesterase
KU224_01995	COG1301	dicarboxylic acid transport
KU224_02010	COG1959	2 iron, 2 sulfur cluster binding
KU224_02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU224_02015	COG1017	nitric oxide dioxygenase activity
KU224_02020	COG0433	COG0433 Predicted ATPase
KU224_02025	COG0626	cystathionine gamma-synthase activity
KU224_02180	COG1960	acyl-CoA dehydrogenase activity
KU224_02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KU224_02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KU224_02220	COG0339	signal peptide processing
KU224_02225	COG0557	exoribonuclease II activity
KU224_02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
KU224_02275	COG2169	Transcriptional regulator
KU224_02280	COG0697	spore germination
KU224_02285	COG1295	ribonuclease BN
KU224_02320	COG1702	phosphate starvation-inducible protein PhoH
KU224_02330	COG0739	heme binding
KU224_02330	COG1196	nuclear chromosome segregation
KU224_02330	COG0741	lytic transglycosylase activity
KU224_02360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KU224_02365	COG1183	phosphatidylcholine synthase activity
KU224_02410	COG1960	acyl-CoA dehydrogenase activity
KU224_02415	COG1309	transcriptional regulator
KU224_02430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KU224_02435	COG1960	acyl-CoA dehydrogenase activity
KU224_02455	COG2969	positive regulation of protein catabolic process
KU224_02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KU224_02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KU224_02485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KU224_02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KU224_02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU224_02520	COG1408	metallophosphoesterase
KU224_02530	COG2199	diguanylate cyclase activity
KU224_02590	COG1607	acyl-coa hydrolase
KU224_02620	COG2350	Protein conserved in bacteria
KU224_02630	COG0613	PHP domain protein
KU224_02635	COG3781	membrane
KU224_02645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KU224_02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KU224_02660	COG1862	Preprotein translocase
KU224_02690	COG2205	protein histidine kinase activity
KU224_02695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KU224_02715	COG0726	polysaccharide deacetylase
KU224_02720	COG0463	Glycosyl transferase, family 2
KU224_02725	COG0438	transferase activity, transferring glycosyl groups
KU224_02790	COG0625	glutathione transferase activity
KU224_02795	COG0583	DNA-binding transcription factor activity
KU224_02800	COG1960	acyl-CoA dehydrogenase activity
KU224_02805	COG1960	acyl-CoA dehydrogenase activity
KU224_02815	COG2205	protein histidine kinase activity
KU224_02820	COG0745	RESPONSE REGULATOR receiver
KU224_02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KU224_02845	COG2096	Adenosyltransferase
KU224_02895	COG0285	dihydrofolate synthase activity
KU224_02915	COG0450	alkyl hydroperoxide reductase
KU224_02930	COG0477	Major facilitator Superfamily
KU224_02935	COG1272	protein, Hemolysin III
KU224_02965	COG0183	Belongs to the thiolase family
KU224_02970	COG2207	Transcriptional regulator
KU224_02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU224_03010	COG0183	Belongs to the thiolase family
KU224_03020	COG2885	chlorophyll binding
KU224_03020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KU224_03030	COG1690	Belongs to the RtcB family
KU224_03035	COG0833	amino acid
KU224_03045	COG2233	PERMEase
KU224_03050	COG1217	gtp-binding protein TYPA
KU224_03075	COG2094	Belongs to the DNA glycosylase MPG family
KU224_03080	COG4772	TonB-dependent receptor
KU224_03095	COG1902	pentaerythritol trinitrate reductase activity
KU224_03110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU224_03115	COG0354	folic acid binding
KU224_03125	COG3189	MarR family transcriptional regulator
KU224_03130	COG2824	Alkylphosphonate utilization operon protein PhnA
KU224_03135	COG3422	double-strand break repair
KU224_03175	COG0840	transmembrane signaling receptor activity
KU224_03195	COG5510	response to toxic substance
KU224_03205	COG2832	Protein of unknown function (DUF454)
KU224_03210	COG1376	ErfK ybiS ycfS ynhG family protein
KU224_03250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KU224_03260	COG1289	transmembrane transporter activity
KU224_03265	COG2814	Major facilitator Superfamily
KU224_03285	COG1115	amino acid carrier protein
KU224_03290	COG1752	Esterase of the alpha-beta hydrolase superfamily
KU224_03295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KU224_03300	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KU224_03340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU224_03350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KU224_03355	COG1077	Cell shape determining protein MreB Mrl
KU224_03360	COG1792	Involved in formation and maintenance of cell shape
KU224_03365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KU224_03370	COG0424	maF-like protein
KU224_03375	COG1530	ribonuclease E activity
KU224_03385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU224_03395	COG0560	Phosphoserine phosphatase
KU224_03405	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU224_03430	COG2207	Transcriptional regulator
KU224_03450	COG1113	amino acid transport
KU224_03455	COG2828	Protein conserved in bacteria
KU224_03460	COG0142	geranyltranstransferase activity
KU224_03465	COG2315	Protein conserved in bacteria
KU224_03480	COG1752	Esterase of the alpha-beta hydrolase superfamily
KU224_03500	COG2194	sulfuric ester hydrolase activity
KU224_03505	COG0745	RESPONSE REGULATOR receiver
KU224_03510	COG0642	Histidine kinase
KU224_03520	COG0004	ammonium transporteR
KU224_03525	COG0583	DNA-binding transcription factor activity
KU224_03545	COG0525	valine-tRNA ligase activity
KU224_03555	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_03565	COG0393	Putative heavy-metal-binding
KU224_03570	COG0393	Putative heavy-metal-binding
KU224_03575	COG1538	Outer membrane efflux protein
KU224_03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU224_03590	COG0671	phosphoesterase, PA-phosphatase related
KU224_03620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KU224_03635	COG1648	precorrin-2 dehydrogenase activity
KU224_03635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KU224_03640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KU224_03645	COG1733	regulation of RNA biosynthetic process
KU224_03655	COG0531	amino acid
KU224_03670	COG0321	lipoyl(octanoyl) transferase activity
KU224_03675	COG2921	Belongs to the UPF0250 family
KU224_03715	COG2009	succinate dehydrogenase
KU224_03720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KU224_03725	COG1053	succinate dehydrogenase
KU224_03730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KU224_03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU224_03775	COG2354	Protein conserved in bacteria
KU224_03780	COG2321	neutral zinc metallopeptidase
KU224_03820	COG2843	Capsule synthesis protein
KU224_03835	COG0589	response to stress
KU224_03855	COG0505	Belongs to the CarA family
KU224_03880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU224_03885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KU224_03935	COG0477	Major facilitator Superfamily
KU224_03940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KU224_03955	COG1597	lipid kinase activity
KU224_03960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KU224_03990	COG0584	glycerophosphoryl diester phosphodiesterase
KU224_04010	COG0741	lytic transglycosylase activity
KU224_04030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KU224_04045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU224_04070	COG0778	Nitroreductase
KU224_04085	COG1929	Belongs to the glycerate kinase type-1 family
KU224_04090	COG0243	molybdopterin cofactor binding
KU224_04095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KU224_04100	COG3339	Conserved Protein
KU224_04110	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KU224_04125	COG1113	amino acid transport
KU224_04135	COG0019	diaminopimelate decarboxylase activity
KU224_04145	COG1280	lysine exporter protein (LysE YggA)
KU224_04150	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KU224_04180	COG0463	Glycosyl transferase, family 2
KU224_04200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU224_04235	COG4591	ABC-type transport system involved in lipoprotein release permease component
KU224_04240	COG1136	(ABC) transporter
KU224_04245	COG0658	competence protein
KU224_04245	COG2333	competence protein COMEC
KU224_04255	COG0616	signal peptide processing
KU224_04255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KU224_04260	COG0596	Alpha beta hydrolase
KU224_04265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KU224_04275	COG0628	permease
KU224_04310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU224_04330	COG0823	Involved in the tonB-independent uptake of proteins
KU224_04350	COG0824	Thioesterase
KU224_04355	COG1473	amidohydrolase
KU224_04375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KU224_04375	COG0047	phosphoribosylformylglycinamidine synthase activity
KU224_04380	COG2814	Major facilitator Superfamily
KU224_04390	COG1024	Enoyl-CoA hydratase
KU224_04395	COG1051	belongs to the nudix hydrolase family
KU224_04395	COG1056	cytidyltransferase-related domain
KU224_04405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KU224_04420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KU224_04435	COG4625	pathogenesis
KU224_04440	COG0583	DNA-binding transcription factor activity
KU224_04445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KU224_04450	COG4208	sulfate ABC transporter
KU224_04455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KU224_04465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KU224_04470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KU224_04475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KU224_04495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KU224_04510	COG0681	Belongs to the peptidase S26 family
KU224_04525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KU224_04535	COG1381	Involved in DNA repair and RecF pathway recombination
KU224_04540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KU224_04550	COG4221	oxidoreductase activity
KU224_04580	COG0436	Aminotransferase
KU224_04600	COG0556	nucleotide-excision repair
KU224_04655	COG2070	2-Nitropropane dioxygenase
KU224_04685	COG1215	transferase activity, transferring glycosyl groups
KU224_04700	COG0415	Belongs to the DNA photolyase family
KU224_04710	COG1252	NADH dehydrogenase
KU224_04715	COG1686	Belongs to the peptidase S11 family
KU224_04730	COG1187	pseudouridine synthase activity
KU224_04755	COG0477	Major facilitator Superfamily
KU224_04760	COG0583	DNA-binding transcription factor activity
KU224_04765	COG1823	symporter activity
KU224_04775	COG0612	Peptidase, M16
KU224_04800	COG0352	thiamine-phosphate diphosphorylase activity
KU224_04835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU224_04850	COG1309	transcriptional regulator
KU224_04860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KU224_04865	COG0076	glutamate decarboxylase activity
KU224_04875	COG1522	sequence-specific DNA binding
KU224_04880	COG3961	Belongs to the TPP enzyme family
KU224_04885	COG1113	amino acid transport
KU224_04890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KU224_04895	COG0573	inorganic phosphate transmembrane transporter activity
KU224_04905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KU224_04910	COG0616	signal peptide processing
KU224_04920	COG3328	transposase activity
KU224_04950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KU224_04955	COG1686	Belongs to the peptidase S11 family
KU224_04980	COG0583	DNA-binding transcription factor activity
KU224_04985	COG1067	ATP-dependent peptidase activity
KU224_05030	COG1966	Carbon starvation protein
KU224_05035	COG2879	small protein
KU224_05065	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KU224_05065	COG2508	Transcriptional regulator
KU224_05085	COG1113	amino acid transport
KU224_05090	COG0583	DNA-binding transcription factor activity
KU224_05095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU224_05100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU224_05110	COG1012	belongs to the aldehyde dehydrogenase family
KU224_05115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU224_05120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU224_05120	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KU224_05155	COG2814	Major facilitator Superfamily
KU224_05160	COG4948	Mandelate Racemase Muconate Lactonizing
KU224_05170	COG1309	transcriptional regulator
KU224_05190	COG1741	Belongs to the pirin family
KU224_05200	COG2964	Protein conserved in bacteria
KU224_05215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU224_05220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KU224_05225	COG4605	iron ion homeostasis
KU224_05230	COG4604	ABC transporter, ATP-binding protein
KU224_05235	COG4607	ABC-type enterochelin transport system periplasmic component
KU224_05240	COG4774	siderophore transport
KU224_05250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KU224_05255	COG1021	2,3-dihydroxybenzoate-AMP ligase
KU224_05260	COG3433	isochorismatase activity
KU224_05260	COG1535	isochorismatase
KU224_05275	COG1132	(ABC) transporter
KU224_05280	COG1132	(ABC) transporter
KU224_05285	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KU224_05295	COG1169	isochorismate synthase
KU224_05310	COG3739	integral membrane protein
KU224_05335	COG0302	gtp cyclohydrolase
KU224_05345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KU224_05375	COG0308	aminopeptidase N
KU224_05380	COG0512	Glutamine amidotransferase of anthranilate synthase
KU224_05570	COG5410	chromosome segregation
KU224_05735	COG0582	viral genome integration into host DNA
KU224_05750	COG0174	glutamine synthetase
KU224_05760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KU224_05795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KU224_05800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KU224_05805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KU224_05825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KU224_05830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KU224_05835	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KU224_05850	COG1960	acyl-CoA dehydrogenase activity
KU224_05855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU224_05860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU224_05870	COG2223	nitrite transmembrane transporter activity
KU224_05880	COG0024	Methionine aminopeptidase
KU224_05885	COG0052	Belongs to the universal ribosomal protein uS2 family
KU224_05900	COG2207	Transcriptional regulator
KU224_05925	COG2951	lytic endotransglycosylase activity
KU224_05930	COG0772	Belongs to the SEDS family
KU224_05945	COG0842	Transport permease protein
KU224_05950	COG1131	(ABC) transporter
KU224_05995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU224_06010	COG4215	(ABC) transporter
KU224_06015	COG4160	amino acid transport
KU224_06020	COG4598	ABC transporter
KU224_06030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU224_06035	COG0826	peptidase U32
KU224_06040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU224_06055	COG1720	tRNA m6t6A37 methyltransferase activity
KU224_06065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KU224_06080	COG0642	Histidine kinase
KU224_06090	COG0494	nUDIX hydrolase
KU224_06100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KU224_06105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KU224_06110	COG3139	Protein of unknown function (DUF1315)
KU224_06115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KU224_06120	COG1301	dicarboxylic acid transport
KU224_06125	COG1960	acyl-CoA dehydrogenase activity
KU224_06130	COG2819	hydrolase of the alpha beta superfamily
KU224_06140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KU224_06150	COG2195	Cleaves the N-terminal amino acid of tripeptides
KU224_06155	COG1234	tRNA 3'-trailer cleavage
KU224_06185	COG2363	Small membrane protein
KU224_06205	COG0513	Belongs to the DEAD box helicase family
KU224_06215	COG0778	Nitroreductase
KU224_06245	COG1286	toxin biosynthetic process
KU224_06270	COG4783	chaperone-mediated protein folding
KU224_06275	COG1610	YqeY-like protein
KU224_06375	COG3111	PFAM Bacterial OB fold (BOF) protein
KU224_06400	COG3243	poly(R)-hydroxyalkanoic acid synthase
KU224_06405	COG0786	glutamate:sodium symporter activity
KU224_06415	COG2186	Transcriptional regulator
KU224_06470	COG0477	Major facilitator Superfamily
KU224_06495	COG2985	domain, Protein
KU224_06505	COG2995	paraquat-inducible protein a
KU224_06510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KU224_06510	COG3008	intermembrane lipid transfer
KU224_06530	COG0482	sulfurtransferase activity
KU224_06545	COG0488	(ABC) transporter
KU224_06550	COG3173	Aminoglycoside phosphotransferase
KU224_06560	COG2433	Pfam Transposase IS66
KU224_06600	COG1301	dicarboxylic acid transport
KU224_06610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU224_06615	COG2011	ABC-type metal ion transport system permease component
KU224_06620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KU224_06625	COG1464	Belongs to the NlpA lipoprotein family
KU224_06630	COG0151	Belongs to the GarS family
KU224_06635	COG0138	bifunctional purine biosynthesis protein purh
KU224_06640	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KU224_06670	COG2308	Evidence 4 Homologs of previously reported genes of
KU224_06680	COG1305	Transglutaminase-like
KU224_06690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KU224_06695	COG0305	Participates in initiation and elongation during chromosome replication
KU224_06720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KU224_06730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KU224_06735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KU224_06760	COG0726	polysaccharide deacetylase
KU224_06760	COG1649	PFAM Uncharacterised BCR, COG1649
KU224_06765	COG1215	transferase activity, transferring glycosyl groups
KU224_06770	COG3658	cytochrome
KU224_06780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU224_06795	COG0583	DNA-binding transcription factor activity
KU224_06815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU224_06820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU224_06835	COG1960	acyl-CoA dehydrogenase activity
KU224_06840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU224_06845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU224_06870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KU224_06875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KU224_06885	COG2205	protein histidine kinase activity
KU224_06890	COG0745	RESPONSE REGULATOR receiver
KU224_06895	COG0174	glutamine synthetase
KU224_06915	COG0729	surface antigen
KU224_06940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU224_06945	COG2814	Major facilitator Superfamily
KU224_06960	COG0583	DNA-binding transcription factor activity
KU224_06975	COG1187	pseudouridine synthase activity
KU224_06995	COG0802	atpase or kinase
KU224_07000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KU224_07010	COG1923	regulation of RNA biosynthetic process
KU224_07015	COG0697	spore germination
KU224_07030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU224_07040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU224_07045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU224_07045	COG0519	Catalyzes the synthesis of GMP from XMP
KU224_07050	COG4302	ethanolamine ammonia-lyase activity
KU224_07055	COG4303	Ethanolamine ammonia lyase large subunit
KU224_07060	COG0531	amino acid
KU224_07080	COG1454	alcohol dehydrogenase
KU224_07085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU224_07095	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KU224_07115	COG0308	aminopeptidase N
KU224_07145	COG1605	Chorismate mutase
KU224_07160	COG1309	transcriptional regulator
KU224_07170	COG0668	transmembrane transport
KU224_07205	COG4773	Receptor
KU224_07225	COG0488	(ABC) transporter
KU224_07230	COG0589	response to stress
KU224_07255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KU224_07265	COG3135	benzoate transporter
KU224_07270	COG1522	sequence-specific DNA binding
KU224_07280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KU224_07285	COG0583	DNA-binding transcription factor activity
KU224_07295	COG0183	Belongs to the thiolase family
KU224_07305	COG2030	dehydratase
KU224_07310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KU224_07325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KU224_07335	COG0824	Thioesterase
KU224_07340	COG1454	alcohol dehydrogenase
KU224_07350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KU224_07370	COG0069	glutamate synthase activity
KU224_07535	COG5410	chromosome segregation
KU224_07660	COG0739	heme binding
KU224_07725	COG2814	Major facilitator Superfamily
KU224_07740	COG0511	ligase activity, forming carbon-carbon bonds
KU224_07760	COG1116	anion transmembrane transporter activity
KU224_07760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU224_07765	COG0745	RESPONSE REGULATOR receiver
KU224_07775	COG2146	nitrite reductase [NAD(P)H] activity
KU224_07775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU224_07780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU224_07785	COG0243	molybdopterin cofactor binding
KU224_07795	COG0243	molybdopterin cofactor binding
KU224_07800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KU224_07815	COG0521	Mo-molybdopterin cofactor biosynthetic process
KU224_07815	COG0315	cyclic pyranopterin monophosphate synthase activity
KU224_07820	COG0303	'Molybdopterin
KU224_07830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU224_07835	COG0697	spore germination
KU224_07855	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KU224_07860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU224_07915	COG2204	response regulator
KU224_07920	COG3852	Histidine kinase
KU224_07940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KU224_07945	COG0575	Belongs to the CDS family
KU224_07980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU224_07995	COG2137	regulation of response to DNA damage stimulus
KU224_08005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KU224_08010	COG1011	Hydrolase
KU224_08035	COG1522	sequence-specific DNA binding
KU224_08045	COG1113	amino acid transport
KU224_08060	COG0659	secondary active sulfate transmembrane transporter activity
KU224_08065	COG2135	peptidase activity
KU224_08080	COG5001	Diguanylate cyclase
KU224_08080	COG3300	MHYT domain
KU224_08100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KU224_08100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KU224_08100	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KU224_08105	COG1105	Belongs to the carbohydrate kinase PfkB family
KU224_08110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KU224_08110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KU224_08140	COG0024	Methionine aminopeptidase
KU224_08145	COG0583	DNA-binding transcription factor activity
KU224_08155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KU224_08160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KU224_08165	COG0517	IMP dehydrogenase activity
KU224_08165	COG0516	GMP reductase activity
KU224_08190	COG0552	protein localization to endoplasmic reticulum
KU224_08200	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KU224_08215	COG4890	Cyd operon protein YbgT
KU224_08220	COG1294	oxidase, subunit
KU224_08235	COG1585	Membrane protein implicated in regulation of membrane protease activity
KU224_08245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KU224_08250	COG4774	siderophore transport
KU224_08265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KU224_08270	COG0569	domain protein
KU224_08275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KU224_08305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KU224_08310	COG0542	response to heat
KU224_08335	COG1902	pentaerythritol trinitrate reductase activity
KU224_08335	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU224_08380	COG2323	membrane
KU224_08385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KU224_08395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU224_08400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU224_08405	COG0183	Belongs to the thiolase family
KU224_08410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KU224_08415	COG0596	Alpha beta hydrolase
KU224_08420	COG2271	Major facilitator Superfamily
KU224_08425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KU224_08430	COG3485	protocatechuate 3,4-dioxygenase
KU224_08435	COG3485	protocatechuate 3,4-dioxygenase
KU224_08440	COG0710	3-dehydroquinate dehydratase activity
KU224_08445	COG3420	alginic acid biosynthetic process
KU224_08450	COG3659	wide pore channel activity
KU224_08455	COG4993	Dehydrogenase
KU224_08465	COG2391	methyltransferase activity
KU224_08480	COG1414	Transcriptional regulator
KU224_08485	COG0583	DNA-binding transcription factor activity
KU224_08490	COG1960	acyl-CoA dehydrogenase activity
KU224_08515	COG2814	Major facilitator Superfamily
KU224_08525	COG0154	amidase activity
KU224_08545	COG4638	Rieske (2fe-2S)
KU224_08555	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_08565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU224_08575	COG3733	amine oxidase
KU224_08585	COG1012	belongs to the aldehyde dehydrogenase family
KU224_08595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU224_08600	COG0183	Belongs to the thiolase family
KU224_08605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU224_08610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU224_08620	COG4829	muconolactone delta-isomerase
KU224_08625	COG4948	Mandelate Racemase Muconate Lactonizing
KU224_08630	COG0583	DNA-binding transcription factor activity
KU224_08640	COG2186	Transcriptional regulator
KU224_08660	COG1012	belongs to the aldehyde dehydrogenase family
KU224_08680	COG1960	acyl-CoA dehydrogenase activity
KU224_08685	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_08690	COG3829	transcription factor binding
KU224_08700	COG3162	membrane
KU224_08715	COG1012	belongs to the aldehyde dehydrogenase family
KU224_08730	COG0753	catalase activity
KU224_08750	COG1846	Transcriptional regulator
KU224_08755	COG1902	pentaerythritol trinitrate reductase activity
KU224_08755	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU224_08765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KU224_08795	COG1309	transcriptional regulator
KU224_08805	COG1335	isochorismatase
KU224_08810	COG0583	DNA-binding transcription factor activity
KU224_08820	COG0475	glutathione-regulated potassium exporter activity
KU224_08820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU224_08830	COG1473	amidohydrolase
KU224_08840	COG2831	hemolysin activation secretion protein
KU224_08845	COG3210	domain, Protein
KU224_08875	COG2188	Transcriptional regulator
KU224_08890	COG0583	DNA-binding transcription factor activity
KU224_08920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KU224_08940	COG1566	PFAM secretion protein HlyD family protein
KU224_08955	COG1012	belongs to the aldehyde dehydrogenase family
KU224_08960	COG0129	dihydroxy-acid dehydratase activity
KU224_08970	COG0583	DNA-binding transcription factor activity
KU224_08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KU224_08985	COG2084	Dehydrogenase
KU224_08990	COG2207	Transcriptional regulator
KU224_09005	COG1064	alcohol dehydrogenase
KU224_09015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KU224_09020	COG1120	ATPase activity
KU224_09040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KU224_09155	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KU224_09205	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_09220	COG2207	Transcriptional regulator
KU224_09230	COG2205	protein histidine kinase activity
KU224_09235	COG0745	RESPONSE REGULATOR receiver
KU224_09240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU224_09245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU224_09250	COG1538	Outer membrane efflux protein
KU224_09260	COG2072	flavoprotein involved in K transport
KU224_09280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU224_09380	COG3539	Fimbrial protein
KU224_09410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KU224_09420	COG0753	catalase activity
KU224_09435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KU224_09500	COG1535	isochorismatase
KU224_09500	COG3433	isochorismatase activity
KU224_09505	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_09510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KU224_09515	COG4149	molybdate abc transporter
KU224_09520	COG0725	ABC transporter, periplasmic molybdate-binding protein
KU224_09530	COG4638	Rieske (2fe-2S)
KU224_09535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KU224_09540	COG0543	2 iron, 2 sulfur cluster binding
KU224_09540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU224_09565	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_09580	COG2207	Transcriptional regulator
KU224_09590	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_09595	COG2610	gluconate transmembrane transporter activity
KU224_09605	COG0583	DNA-binding transcription factor activity
KU224_09615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU224_09620	COG2031	fatty acid transporter
KU224_09625	COG0183	Belongs to the thiolase family
KU224_09630	COG0583	DNA-binding transcription factor activity
KU224_09635	COG0583	DNA-binding transcription factor activity
KU224_09650	COG1027	Aspartate ammonia-lyase
KU224_09660	COG0477	Major facilitator Superfamily
KU224_09680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU224_09685	COG4521	taurine ABC transporter
KU224_09700	COG2188	Transcriptional regulator
KU224_09710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KU224_09715	COG1733	regulation of RNA biosynthetic process
KU224_09720	COG2207	Transcriptional regulator
KU224_09720	COG3708	Transcriptional regulator
KU224_09735	COG0730	response to heat
KU224_09745	COG3453	Protein conserved in bacteria
KU224_09745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU224_09755	COG3781	membrane
KU224_09760	COG1063	alcohol dehydrogenase
KU224_09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KU224_09775	COG0508	dehydrogenase complex catalyzes the overall conversion of
KU224_09780	COG0022	dehydrogenase e1 component
KU224_09785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KU224_09790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KU224_09805	COG3706	GGDEF domain
KU224_09820	COG0133	tryptophan synthase activity
KU224_09830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KU224_09865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KU224_09890	COG2226	methyltransferase
KU224_09945	COG0842	Transport permease protein
KU224_09950	COG0842	Transport permease protein
KU224_09955	COG1131	(ABC) transporter
KU224_09970	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KU224_09975	COG4773	Receptor
KU224_09995	COG0730	response to heat
KU224_10000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KU224_10020	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KU224_10035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KU224_10075	COG4264	IucA IucC family
KU224_10080	COG4264	IucA IucC family
KU224_10100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KU224_10115	COG1960	acyl-CoA dehydrogenase activity
KU224_10120	COG1960	acyl-CoA dehydrogenase activity
KU224_10125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KU224_10130	COG2207	Transcriptional regulator
KU224_10135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU224_10140	COG0776	regulation of translation
KU224_10165	COG0822	iron-sulfur transferase activity
KU224_10170	COG0316	Belongs to the HesB IscA family
KU224_10200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KU224_10220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KU224_10225	COG0702	epimerase
KU224_10260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KU224_10270	COG0339	signal peptide processing
KU224_10320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KU224_10325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KU224_10355	COG0776	regulation of translation
KU224_10420	COG0084	hydrolase, TatD family'
KU224_10440	COG1663	tetraacyldisaccharide 4'-kinase activity
KU224_10445	COG1132	(ABC) transporter
KU224_10455	COG0811	peptide transport
KU224_10460	COG1475	DNA binding
KU224_10465	COG1192	Involved in chromosome partitioning
KU224_10475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KU224_10490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KU224_10495	COG0191	fructose-bisphosphate aldolase activity
KU224_10515	COG0424	maF-like protein
KU224_10520	COG2850	peptidyl-arginine hydroxylation
KU224_10530	COG0640	Transcriptional regulator
KU224_10545	COG3619	membrane
KU224_10550	COG3122	Protein conserved in bacteria
KU224_10555	COG1132	(ABC) transporter
KU224_10575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KU224_10580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KU224_10590	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KU224_10590	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KU224_10590	COG0506	proline dehydrogenase activity
KU224_10595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KU224_10610	COG3698	Phosphodiester glycosidase
KU224_10620	COG2353	YceI-like domain
KU224_10630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KU224_10675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KU224_10675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KU224_10700	COG3539	Fimbrial protein
KU224_10705	COG3121	Chaperone
KU224_10730	COG0697	spore germination
KU224_10740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KU224_10750	COG0583	DNA-binding transcription factor activity
KU224_10770	COG1309	transcriptional regulator
KU224_10785	COG1522	sequence-specific DNA binding
KU224_10795	COG1126	abc transporter atp-binding protein
KU224_10800	COG0765	amino acid transport
KU224_10805	COG0765	amino acid transport
KU224_10835	COG1464	Belongs to the NlpA lipoprotein family
KU224_10845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KU224_10850	COG2011	ABC-type metal ion transport system permease component
KU224_10855	COG0012	GTP binding
KU224_10880	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KU224_10930	COG0436	Aminotransferase
KU224_10970	COG3634	alkyl hydroperoxide reductase activity
KU224_10985	COG0583	DNA-binding transcription factor activity
KU224_10990	COG0798	PFAM Bile acid sodium symporter
KU224_10995	COG0640	Transcriptional regulator
KU224_11010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KU224_11020	COG0583	DNA-binding transcription factor activity
KU224_11030	COG1953	Uracil, thiamine, allantoin
KU224_11040	COG2175	clavaminate synthase activity
KU224_11045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU224_11050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KU224_11055	COG4521	taurine ABC transporter
KU224_11065	COG0477	Major facilitator Superfamily
KU224_11085	COG1271	oxidase subunit
KU224_11090	COG1294	oxidase, subunit
KU224_11100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KU224_11120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KU224_11140	COG3052	prosthetic group binding
KU224_11145	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KU224_11155	COG2814	Major facilitator Superfamily
KU224_11175	COG1346	cytolysis
KU224_11185	COG0583	DNA-binding transcription factor activity
KU224_11190	COG0625	glutathione transferase activity
KU224_11195	COG0625	glutathione transferase activity
KU224_11200	COG0583	DNA-binding transcription factor activity
KU224_11215	COG1045	serine acetyltransferase
KU224_11220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KU224_11225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KU224_11235	COG1280	lysine exporter protein (LysE YggA)
KU224_11250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU224_11255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU224_11260	COG1126	abc transporter atp-binding protein
KU224_11265	COG0765	amino acid transport
KU224_11270	COG0765	amino acid transport
KU224_11290	COG0784	Response regulator, receiver
KU224_11290	COG2205	protein histidine kinase activity
KU224_11310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KU224_11330	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_11380	COG0583	DNA-binding transcription factor activity
KU224_11400	COG0318	PFAM AMP-dependent synthetase and ligase
KU224_11405	COG1309	transcriptional regulator
KU224_11410	COG1960	acyl-CoA dehydrogenase activity
KU224_11415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KU224_11420	COG1024	Enoyl-CoA hydratase
KU224_11425	COG4770	biotin carboxylase activity
KU224_11435	COG0583	DNA-binding transcription factor activity
KU224_11450	COG1960	acyl-CoA dehydrogenase activity
KU224_11460	COG2814	Major facilitator Superfamily
KU224_11470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KU224_11475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KU224_11480	COG2814	Major facilitator Superfamily
KU224_11485	COG1960	acyl-CoA dehydrogenase activity
KU224_11490	COG1024	Enoyl-CoA hydratase
KU224_11495	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_11500	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU224_11505	COG0183	Belongs to the thiolase family
KU224_11515	COG2814	Major facilitator Superfamily
KU224_11525	COG1024	Enoyl-CoA hydratase
KU224_11540	COG1960	acyl-CoA dehydrogenase activity
KU224_11545	COG2814	Major facilitator Superfamily
KU224_11550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KU224_11555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KU224_11570	COG3842	ATPase activity
KU224_11575	COG1840	ABC-type Fe3 transport system, periplasmic component
KU224_11585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU224_11590	COG1414	Transcriptional regulator
KU224_11600	COG0583	DNA-binding transcription factor activity
KU224_11605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KU224_11610	COG1012	belongs to the aldehyde dehydrogenase family
KU224_11620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KU224_11630	COG1012	belongs to the aldehyde dehydrogenase family
KU224_11635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU224_11640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU224_11645	COG2267	carboxylic ester hydrolase activity
KU224_11665	COG3038	cytochrome b561
KU224_11670	COG0753	catalase activity
KU224_11705	COG2050	protein possibly involved in aromatic compounds catabolism
KU224_11715	COG3327	negative regulation of DNA-templated transcription, initiation
KU224_11720	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KU224_11725	COG0183	Belongs to the thiolase family
KU224_11730	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU224_11735	COG1024	Enoyl-CoA hydratase
KU224_11740	COG1024	Enoyl-CoA hydratase
KU224_11745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KU224_11750	COG2151	metal-sulfur cluster biosynthetic enzyme
KU224_11755	COG3396	Phenylacetate-CoA oxygenase
KU224_11760	COG3460	Phenylacetate-CoA oxygenase
KU224_11765	COG3396	Phenylacetate-CoA oxygenase
KU224_11770	COG2030	dehydratase
KU224_11770	COG1012	belongs to the aldehyde dehydrogenase family
KU224_11775	COG1760	l-serine dehydratase
KU224_11780	COG0531	amino acid
KU224_11785	COG1012	belongs to the aldehyde dehydrogenase family
KU224_11800	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU224_11810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KU224_11830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU224_11840	COG0789	Transcriptional regulator
KU224_11855	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KU224_11870	COG2807	transmembrane transport
KU224_11875	COG0590	tRNA wobble adenosine to inosine editing
KU224_11990	COG1116	anion transmembrane transporter activity
KU224_11995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KU224_12005	COG0864	Transcriptional regulator
KU224_12025	COG2249	NAD(P)H dehydrogenase (quinone) activity
KU224_12030	COG0439	Biotin carboxylase
KU224_12045	COG1063	alcohol dehydrogenase
KU224_12055	COG1309	transcriptional regulator
KU224_12075	COG0038	chloride channel
KU224_12080	COG4770	biotin carboxylase activity
KU224_12100	COG1914	H( )-stimulated, divalent metal cation uptake system
KU224_12105	COG0583	DNA-binding transcription factor activity
KU224_12155	COG1250	3-hydroxyacyl-CoA dehydrogenase
KU224_12175	COG2814	Major facilitator Superfamily
KU224_12185	COG1560	Kdo2-lipid A biosynthetic process
KU224_12195	COG5006	permease, DMT superfamily
KU224_12200	COG1522	sequence-specific DNA binding
KU224_12215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KU224_12225	COG4122	O-methyltransferase activity
KU224_12255	COG1538	Outer membrane efflux protein
KU224_12260	COG1137	ATPase activity
KU224_12265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KU224_12275	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KU224_12280	COG0517	IMP dehydrogenase activity
KU224_12280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KU224_12315	COG2814	Major facilitator Superfamily
KU224_12350	COG1278	Cold shock
KU224_12355	COG1280	lysine exporter protein (LysE YggA)
KU224_12385	COG1570	exodeoxyribonuclease VII activity
KU224_12435	COG0583	DNA-binding transcription factor activity
KU224_12440	COG4638	Rieske (2fe-2S)
KU224_12445	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KU224_12450	COG0543	2 iron, 2 sulfur cluster binding
KU224_12450	COG0633	Ferredoxin
KU224_12455	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_12460	COG3135	benzoate transporter
KU224_12465	COG2814	Major facilitator Superfamily
KU224_12480	COG1643	Atp-dependent helicase
KU224_12485	COG0450	alkyl hydroperoxide reductase
KU224_12495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KU224_12505	COG3634	alkyl hydroperoxide reductase activity
KU224_12525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KU224_12530	COG0625	glutathione transferase activity
KU224_12540	COG2885	chlorophyll binding
KU224_12575	COG0542	response to heat
KU224_12590	COG1765	OsmC-like protein
KU224_12610	COG0667	Aldo Keto reductase
KU224_12625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KU224_12635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KU224_12645	COG0527	aspartate kinase activity
KU224_12655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KU224_12665	COG3038	cytochrome b561
KU224_12670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KU224_12675	COG2252	PERMEase
KU224_12685	COG2072	flavoprotein involved in K transport
KU224_12700	COG1741	Belongs to the pirin family
KU224_12705	COG1309	transcriptional regulator
KU224_12725	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU224_12725	COG1902	pentaerythritol trinitrate reductase activity
KU224_12735	COG2203	Gaf domain
KU224_12735	COG3706	GGDEF domain
KU224_12735	COG4251	negative regulation of phosphorylation
KU224_12735	COG5001	Diguanylate cyclase
KU224_12745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU224_12765	COG4172	Belongs to the ABC transporter superfamily
KU224_12770	COG4239	(ABC) transporter, permease
KU224_12775	COG4174	ABC transporter (Permease)
KU224_12785	COG0741	lytic transglycosylase activity
KU224_12785	COG1388	LysM domain
KU224_12785	COG1388	LysM domain
KU224_12785	COG0741	lytic transglycosylase activity
KU224_12790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU224_12830	COG0583	DNA-binding transcription factor activity
KU224_12835	COG1279	arginine transmembrane transporter activity
KU224_12855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU224_12860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU224_12865	COG0006	proline dipeptidase activity
KU224_12905	COG2194	sulfuric ester hydrolase activity
KU224_12950	COG0739	heme binding
KU224_13280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KU224_13305	COG3384	dioxygenase
KU224_13315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KU224_13320	COG2878	Part of a membrane complex involved in electron transport
KU224_13325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KU224_13350	COG0768	penicillin binding
KU224_13355	COG0742	ribosomal rna small subunit methyltransferase
KU224_13370	COG0830	nickel cation binding
KU224_13420	COG1253	flavin adenine dinucleotide binding
KU224_13425	COG2851	Citrate transporter
KU224_13480	COG1773	rubredoxin
KU224_13485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KU224_13495	COG0583	DNA-binding transcription factor activity
KU224_13520	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KU224_13525	COG4181	ATPase activity
KU224_13570	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KU224_13590	COG0306	phosphate transporter
KU224_13600	COG3958	Transketolase
KU224_13605	COG3959	Transketolase, thiamine diphosphate binding domain
KU224_13610	COG2271	Major facilitator Superfamily
KU224_13615	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_13620	COG0583	DNA-binding transcription factor activity
KU224_13635	COG2223	nitrite transmembrane transporter activity
KU224_13640	COG2207	Transcriptional regulator
KU224_13645	COG2066	Belongs to the glutaminase family
KU224_13650	COG0242	peptide deformylase activity
KU224_13655	COG0477	Major facilitator Superfamily
KU224_13665	COG0028	Belongs to the TPP enzyme family
KU224_13680	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_13685	COG2267	carboxylic ester hydrolase activity
KU224_13695	COG2271	Major facilitator Superfamily
KU224_13700	COG0446	pyridine nucleotide-disulphide oxidoreductase
KU224_13710	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_13730	COG1414	Transcriptional regulator
KU224_13745	COG1024	Enoyl-CoA hydratase
KU224_13755	COG1215	transferase activity, transferring glycosyl groups
KU224_13760	COG0726	polysaccharide deacetylase
KU224_13760	COG1649	PFAM Uncharacterised BCR, COG1649
KU224_13770	COG4681	YaeQ
KU224_13780	COG0523	cobalamin synthesis protein
KU224_13790	COG1607	acyl-coa hydrolase
KU224_13800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU224_13805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KU224_13810	COG1309	transcriptional regulator
KU224_13835	COG2040	homocysteine
KU224_13840	COG0531	amino acid
KU224_13895	COG1595	DNA-templated transcription, initiation
KU224_13905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU224_13910	COG0477	Major facilitator Superfamily
KU224_13930	COG0084	hydrolase, TatD family'
KU224_13965	COG0629	single-stranded DNA binding
KU224_14020	COG0582	viral genome integration into host DNA
KU224_14120	COG0592	DNA-directed DNA polymerase activity
KU224_14160	COG2026	Addiction module toxin, RelE StbE family
KU224_14330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KU224_14400	COG0405	Gamma-glutamyltransferase
KU224_14405	COG2814	Major facilitator Superfamily
KU224_14415	COG2050	protein possibly involved in aromatic compounds catabolism
KU224_14430	COG1090	epimerase
KU224_14450	COG0420	3'-5' exonuclease activity
KU224_14475	COG0735	belongs to the Fur family
KU224_14480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KU224_14500	COG0121	glutamine amidotransferase
KU224_14515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU224_14525	COG0210	DNA helicase
KU224_14530	COG2885	chlorophyll binding
KU224_14535	COG0204	Acyl-transferase
KU224_14550	COG2894	cell division
KU224_14575	COG1280	lysine exporter protein (LysE YggA)
KU224_14580	COG1674	ftsk spoiiie
KU224_14580	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KU224_14585	COG0492	ferredoxin-NADP+ reductase activity
KU224_14590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KU224_14600	COG0456	acetyltransferase
KU224_14645	COG1981	membrane
KU224_14660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KU224_14660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU224_14680	COG1012	belongs to the aldehyde dehydrogenase family
KU224_14690	COG0657	acetylesterase activity
KU224_14700	COG0473	3-isopropylmalate dehydrogenase activity
KU224_14705	COG0583	DNA-binding transcription factor activity
KU224_14725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KU224_14750	COG0564	pseudouridine synthase activity
KU224_14760	COG0358	DNA primase activity
KU224_14775	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KU224_14805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KU224_14835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KU224_14845	COG0352	thiamine-phosphate diphosphorylase activity
KU224_14845	COG0351	phosphomethylpyrimidine kinase
KU224_14845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KU224_14850	COG1652	LysM domain
KU224_14875	COG1399	metal-binding, possibly nucleic acid-binding protein
KU224_14880	COG3101	peptidyl-lysine hydroxylation
KU224_14885	COG0009	L-threonylcarbamoyladenylate synthase
KU224_14890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KU224_14895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KU224_14910	COG4106	trans-aconitate 2-methyltransferase activity
KU224_14925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU224_14925	COG2226	methyltransferase
KU224_14925	COG0596	Alpha beta hydrolase
KU224_14930	COG1877	trehalose-phosphatase activity
KU224_14935	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KU224_14940	COG2223	nitrite transmembrane transporter activity
KU224_14960	COG1196	nuclear chromosome segregation
KU224_14970	COG0730	response to heat
KU224_14985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KU224_14995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU224_15045	COG0489	protein tyrosine kinase activity
KU224_15055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU224_15055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU224_15085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KU224_15090	COG2081	HI0933 family
KU224_15100	COG0668	transmembrane transport
KU224_15120	COG0583	DNA-binding transcription factor activity
KU224_15140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KU224_15145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KU224_15175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KU224_15215	COG0745	RESPONSE REGULATOR receiver
KU224_15235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KU224_15245	COG2205	protein histidine kinase activity
KU224_15315	COG4993	Dehydrogenase
KU224_15340	COG0384	phenazine biosynthesis protein PhzF
KU224_15360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KU224_15375	COG0583	DNA-binding transcription factor activity
KU224_15405	COG0583	DNA-binding transcription factor activity
KU224_15420	COG0583	DNA-binding transcription factor activity
KU224_15425	COG1053	succinate dehydrogenase
KU224_15435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KU224_15440	COG2814	Major facilitator Superfamily
KU224_15445	COG1960	acyl-CoA dehydrogenase activity
KU224_15450	COG0583	DNA-binding transcription factor activity
KU224_15455	COG1063	alcohol dehydrogenase
KU224_15485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KU224_15490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KU224_15495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU224_15510	COG3667	copper resistance
KU224_15515	COG2132	Multicopper oxidase
KU224_15525	COG0561	phosphatase activity
KU224_15530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KU224_15555	COG1214	PFAM Peptidase M22, glycoprotease
KU224_15610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KU224_15620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KU224_15625	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KU224_15630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KU224_15690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KU224_15700	COG1846	Transcriptional regulator
KU224_15705	COG1764	response to oxidative stress
KU224_15785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KU224_15830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU224_15870	COG0589	response to stress
KU224_15875	COG0659	secondary active sulfate transmembrane transporter activity
KU224_15905	COG0037	tRNA processing
KU224_15915	COG0248	Ppx GppA phosphatase
KU224_15945	COG0072	phenylalanine-tRNA ligase activity
KU224_15985	COG1238	metal cluster binding
KU224_15990	COG0625	glutathione transferase activity
KU224_16005	COG0318	PFAM AMP-dependent synthetase and ligase
KU224_16010	COG3028	Belongs to the UPF0307 family
KU224_16015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KU224_16035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KU224_16040	COG0617	tRNA 3'-terminal CCA addition
KU224_16045	COG1555	photosystem II stabilization
KU224_16050	COG3956	TIGRFAM MazG family protein
KU224_16060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KU224_16080	COG5002	protein histidine kinase activity
KU224_16080	COG2205	protein histidine kinase activity
KU224_16080	COG0784	Response regulator, receiver
KU224_16085	COG1024	Enoyl-CoA hydratase
KU224_16090	COG2084	Dehydrogenase
KU224_16095	COG3622	Belongs to the hyi family
KU224_16125	COG0697	spore germination
KU224_16135	COG2814	Major facilitator Superfamily
KU224_16140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KU224_16150	COG0583	DNA-binding transcription factor activity
KU224_16160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KU224_16175	COG0084	hydrolase, TatD family'
KU224_16190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KU224_16220	COG0440	acetolactate synthase activity
KU224_16225	COG0028	Belongs to the TPP enzyme family
KU224_16250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KU224_16255	COG0577	efflux transmembrane transporter activity
KU224_16255	COG1136	(ABC) transporter
KU224_16260	COG1538	Outer membrane efflux protein
KU224_16275	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KU224_16280	COG1162	GTPase activity
KU224_16290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KU224_16310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KU224_16315	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_16355	COG2986	histidine ammonia-lyase
KU224_16370	COG0318	PFAM AMP-dependent synthetase and ligase
KU224_16380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU224_16425	COG1426	Protein conserved in bacteria
KU224_16460	COG0793	Belongs to the peptidase S41A family
KU224_16475	COG2267	carboxylic ester hydrolase activity
KU224_16485	COG1012	belongs to the aldehyde dehydrogenase family
KU224_16490	COG3265	gluconokinase activity
KU224_16500	COG0800	Aldolase
KU224_16515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KU224_16520	COG0857	belongs to the CobB CobQ family
KU224_16520	COG0280	phosphate acetyltransferase
KU224_16525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KU224_16525	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KU224_16545	COG0740	serine-type endopeptidase activity
KU224_16555	COG4774	siderophore transport
KU224_16565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KU224_16575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KU224_16575	COG2813	Specifically methylates the guanine in position
KU224_16675	COG0788	formyltetrahydrofolate deformylase activity
KU224_16700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU224_16700	COG4651	solute:proton antiporter activity
KU224_16720	COG0724	RNA recognition motif
KU224_16725	COG0210	DNA helicase
KU224_16750	COG1733	regulation of RNA biosynthetic process
KU224_16760	COG2900	Belongs to the SlyX family
KU224_16765	COG0488	(ABC) transporter
KU224_16770	COG1280	lysine exporter protein (LysE YggA)
KU224_16775	COG1560	Kdo2-lipid A biosynthetic process
KU224_16785	COG1301	dicarboxylic acid transport
KU224_16840	COG0473	3-isopropylmalate dehydrogenase activity
KU224_16905	COG0583	DNA-binding transcription factor activity
KU224_16915	COG0625	glutathione transferase activity
KU224_16920	COG2378	regulation of single-species biofilm formation
KU224_16925	COG0546	phosphoglycolate phosphatase activity
KU224_16935	COG1530	ribonuclease E activity
KU224_16940	COG0318	PFAM AMP-dependent synthetase and ligase
KU224_16955	COG0583	DNA-binding transcription factor activity
KU224_16960	COG4221	oxidoreductase activity
KU224_16965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KU224_16975	COG0534	Mate efflux family protein
KU224_16990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KU224_17030	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KU224_17035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KU224_17050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KU224_17060	COG0644	oxidoreductase
KU224_17060	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KU224_17065	COG0425	Belongs to the sulfur carrier protein TusA family
KU224_17070	COG4535	Mg2 and Co2 transporter CorC
KU224_17080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KU224_17100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KU224_17105	COG0475	glutathione-regulated potassium exporter activity
KU224_17105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KU224_17110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KU224_17120	COG0484	heat shock protein binding
KU224_17125	COG0789	Transcriptional regulator
KU224_17130	COG0598	Magnesium transport protein CorA
KU224_17145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KU224_17150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KU224_17155	COG1074	ATP-dependent DNA helicase activity
KU224_17160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KU224_17180	COG2226	methyltransferase
KU224_17195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KU224_17200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KU224_17215	COG2111	Na H antiporter
KU224_17215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KU224_17220	COG1006	Multisubunit Na H antiporter MnhC subunit
KU224_17225	COG0651	ATP synthesis coupled electron transport
KU224_17230	COG1863	multisubunit Na H antiporter MnhE subunit
KU224_17235	COG2212	antiporter activity
KU224_17240	COG1320	monovalent cation:proton antiporter activity
KU224_17255	COG0195	Participates in both transcription termination and antitermination
KU224_17305	COG0237	dephospho-CoA kinase activity
KU224_17315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KU224_17330	COG0497	DNA recombination
KU224_17340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KU224_17370	COG2169	Transcriptional regulator
KU224_17370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KU224_17375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KU224_17440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KU224_17455	COG0326	Molecular chaperone. Has ATPase activity
KU224_17470	COG2056	Na+-H+ antiporter family
KU224_17475	COG0596	Alpha beta hydrolase
KU224_17570	COG0546	phosphoglycolate phosphatase activity
KU224_17575	COG1716	ATPase activity
KU224_17620	COG0181	hydroxymethylbilane synthase activity
KU224_17630	COG3275	phosphorelay sensor kinase activity
KU224_17650	COG1538	Outer membrane efflux protein
KU224_17655	COG0697	spore germination
KU224_17680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KU224_17685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KU224_17690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KU224_17695	COG0772	Belongs to the SEDS family
KU224_17720	COG4974	Belongs to the 'phage' integrase family
KU224_17725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU224_17735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KU224_17745	COG2197	response regulator
KU224_17760	COG0793	Belongs to the peptidase S41A family
KU224_17765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KU224_17770	COG0795	lipopolysaccharide-transporting ATPase activity
KU224_17810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU224_17810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KU224_17820	COG0004	ammonium transporteR
KU224_17825	COG0347	Belongs to the P(II) protein family
KU224_17835	COG0606	chelatase, subunit chli
KU224_17885	COG0659	secondary active sulfate transmembrane transporter activity
KU224_17890	COG0589	response to stress
KU224_17920	COG0606	chelatase, subunit chli
KU224_17935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KU224_17950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KU224_17965	COG0318	PFAM AMP-dependent synthetase and ligase
KU224_17975	COG0477	Major facilitator Superfamily
KU224_17980	COG2860	membrane
KU224_17990	COG1253	flavin adenine dinucleotide binding
KU224_18010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KU224_18045	COG0655	NAD(P)H dehydrogenase (quinone) activity
KU224_18055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KU224_18090	COG1309	transcriptional regulator
KU224_18125	COG0758	DNA mediated transformation
KU224_18135	COG0697	spore germination
KU224_18140	COG1309	transcriptional regulator
KU224_18155	COG0386	Belongs to the glutathione peroxidase family
KU224_18220	COG1121	(ABC) transporter
KU224_18225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KU224_18230	COG1280	lysine exporter protein (LysE YggA)
KU224_18235	COG2837	iron assimilation
KU224_18245	COG0281	malic enzyme
KU224_18290	COG0519	Catalyzes the synthesis of GMP from XMP
KU224_18290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KU224_18295	COG4399	Belongs to the UPF0754 family
KU224_18300	COG2259	Doxx family
KU224_18305	COG0586	Pfam SNARE associated Golgi protein
KU224_18320	COG1192	Involved in chromosome partitioning
KU224_18330	COG0271	Belongs to the BolA IbaG family
KU224_18350	COG2267	carboxylic ester hydrolase activity
KU224_18370	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KU224_18370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KU224_18370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KU224_18370	COG3321	synthase
KU224_18375	COG1960	acyl-CoA dehydrogenase activity
KU224_18385	COG2197	response regulator
KU224_18395	COG3916	Acyl-homoserine-lactone synthase
KU224_18400	COG0477	Major facilitator Superfamily
KU224_18405	COG1024	Enoyl-CoA hydratase
KU224_18410	COG1024	Enoyl-CoA hydratase
KU224_18415	COG1960	acyl-CoA dehydrogenase activity
KU224_18420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KU224_18440	COG1113	amino acid transport
KU224_18445	COG1113	amino acid transport
KU224_18450	COG0251	oxidation-reduction process
KU224_18490	COG0564	pseudouridine synthase activity
KU224_18550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KU224_18565	COG1802	Transcriptional regulator
KU224_18575	COG1448	Aminotransferase
KU224_18580	COG0277	FAD linked oxidase domain protein
KU224_18590	COG2186	Transcriptional regulator
KU224_18600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KU224_18605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KU224_18620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KU224_18625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KU224_18630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KU224_18685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KU224_18690	COG1596	polysaccharide export
KU224_18715	COG0728	peptidoglycan biosynthetic process
KU224_18720	COG3023	N-Acetylmuramoyl-L-alanine amidase
KU224_18775	COG0546	phosphoglycolate phosphatase activity
KU224_18780	COG1028	Short-chain dehydrogenase reductase Sdr
KU224_18800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU224_18805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KU224_18810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KU224_18815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KU224_18820	COG1116	anion transmembrane transporter activity
KU224_18825	COG1309	transcriptional regulator
KU224_18830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KU224_18840	COG0196	riboflavin kinase activity
KU224_18845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KU224_18855	COG1047	Peptidyl-prolyl cis-trans
KU224_18895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KU224_18900	COG0657	acetylesterase activity
KU224_18950	COG2951	lytic endotransglycosylase activity
KU224_18955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KU224_18970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KU224_18980	COG0671	phosphoesterase, PA-phosphatase related
KU224_18985	COG0861	Integral membrane protein TerC family
KU224_18995	COG0754	glutathionylspermidine amidase activity
KU224_19005	COG0402	S-adenosylhomocysteine deaminase activity
KU224_19020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KU224_19025	COG1230	cation diffusion facilitator family transporter
KU224_19040	COG0706	membrane insertase activity
KU224_19110	COG1525	nuclease
KU224_19185	COG0589	response to stress
KU224_19190	COG0659	secondary active sulfate transmembrane transporter activity
KU224_19230	COG1475	DNA binding
KU224_19245	COG3853	Toxic anion resistance protein (TelA)
KU224_19345	COG0484	heat shock protein binding
KU224_19435	COG0741	lytic transglycosylase activity
KU224_19470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process