locus-tag	class	description
HFD81_00010	COG0592	DNA-directed DNA polymerase activity
HFD81_00020	COG0187	DNA topoisomerase II activity
HFD81_00030	COG0586	Pfam SNARE associated Golgi protein
HFD81_00035	COG0488	(ABC) transporter
HFD81_00060	COG0596	Alpha beta hydrolase
HFD81_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HFD81_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFD81_00110	COG0733	neurotransmitter:sodium symporter activity
HFD81_00150	COG2233	PERMEase
HFD81_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD81_00200	COG2814	Major facilitator Superfamily
HFD81_00205	COG0656	L-ascorbic acid biosynthetic process
HFD81_00210	COG0583	DNA-binding transcription factor activity
HFD81_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD81_00230	COG1064	alcohol dehydrogenase
HFD81_00235	COG2818	Glycosylase
HFD81_00250	COG1194	a g-specific adenine glycosylase
HFD81_00270	COG2983	Belongs to the UPF0260 family
HFD81_00275	COG2133	pyrroloquinoline quinone binding
HFD81_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFD81_00285	COG2116	formate transmembrane transporter activity
HFD81_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD81_00310	COG1335	isochorismatase
HFD81_00315	COG0385	Bile acid
HFD81_00320	COG0534	Mate efflux family protein
HFD81_00325	COG1683	Conserved Protein
HFD81_00345	COG0625	glutathione transferase activity
HFD81_00355	COG1113	amino acid transport
HFD81_00365	COG0523	cobalamin synthesis protein
HFD81_00375	COG2188	Transcriptional regulator
HFD81_00405	COG0010	Belongs to the arginase family
HFD81_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFD81_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HFD81_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFD81_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HFD81_00540	COG0534	Mate efflux family protein
HFD81_00545	COG0436	Aminotransferase
HFD81_00550	COG2733	membrane
HFD81_00565	COG2918	glutathione biosynthetic process
HFD81_00575	COG3501	Rhs element vgr protein
HFD81_00580	COG1388	LysM domain
HFD81_00580	COG0791	NLP P60 protein
HFD81_00595	COG3150	esterase
HFD81_00605	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HFD81_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD81_00630	COG2233	PERMEase
HFD81_00635	COG2351	hydroxyisourate hydrolase activity
HFD81_00670	COG3706	GGDEF domain
HFD81_00685	COG1393	Belongs to the ArsC family
HFD81_00690	COG0708	Exodeoxyribonuclease III
HFD81_00710	COG0189	ligase activity
HFD81_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFD81_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFD81_00755	COG4942	peptidase
HFD81_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFD81_00775	COG2119	membrane
HFD81_00785	COG2433	Pfam Transposase IS66
HFD81_00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD81_00805	COG0426	domain, Protein
HFD81_00830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HFD81_00850	COG1902	pentaerythritol trinitrate reductase activity
HFD81_00855	COG1519	Transferase
HFD81_00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFD81_00865	COG0668	transmembrane transport
HFD81_00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD81_00880	COG1335	isochorismatase
HFD81_00885	COG1522	sequence-specific DNA binding
HFD81_00890	COG3328	transposase activity
HFD81_00915	COG2205	protein histidine kinase activity
HFD81_00915	COG2198	Histidine kinase
HFD81_00915	COG0784	Response regulator, receiver
HFD81_00920	COG3162	membrane
HFD81_00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFD81_00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD81_00945	COG3706	GGDEF domain
HFD81_00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFD81_00960	COG1309	transcriptional regulator
HFD81_00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFD81_00980	COG0352	thiamine-phosphate diphosphorylase activity
HFD81_00980	COG0351	phosphomethylpyrimidine kinase
HFD81_00990	COG2814	Major facilitator Superfamily
HFD81_01005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFD81_01015	COG1113	amino acid transport
HFD81_01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFD81_01030	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_01040	COG1335	isochorismatase
HFD81_01055	COG1061	Type III restriction enzyme res subunit
HFD81_01065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFD81_01070	COG1192	Involved in chromosome partitioning
HFD81_01080	COG1061	Type III restriction enzyme res subunit
HFD81_01120	COG2814	Major facilitator Superfamily
HFD81_01125	COG0583	DNA-binding transcription factor activity
HFD81_01145	COG0667	Aldo Keto reductase
HFD81_01175	COG1733	regulation of RNA biosynthetic process
HFD81_01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD81_01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HFD81_01260	COG2329	Antibiotic biosynthesis monooxygenase
HFD81_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFD81_01320	COG0427	acetyl-CoA hydrolase
HFD81_01335	COG0745	RESPONSE REGULATOR receiver
HFD81_01345	COG0659	secondary active sulfate transmembrane transporter activity
HFD81_01350	COG4221	oxidoreductase activity
HFD81_01355	COG2873	o-acetylhomoserine
HFD81_01360	COG0488	(ABC) transporter
HFD81_01445	COG0833	amino acid
HFD81_01490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HFD81_01495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFD81_01510	COG2226	methyltransferase
HFD81_01560	COG0067	glutamate synthase
HFD81_01560	COG0069	glutamate synthase activity
HFD81_01560	COG0070	glutamate synthase
HFD81_01565	COG0493	'glutamate synthase
HFD81_01575	COG1704	LemA family
HFD81_01580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HFD81_01600	COG3307	-O-antigen
HFD81_01620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFD81_01635	COG0194	GDP metabolic process
HFD81_01685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFD81_01705	COG5380	lipid catabolic process
HFD81_01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFD81_01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFD81_01740	COG0277	FAD linked oxidase domain protein
HFD81_01750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HFD81_01755	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD81_01770	COG1289	transmembrane transporter activity
HFD81_01780	COG0628	permease
HFD81_01785	COG1192	Involved in chromosome partitioning
HFD81_01815	COG0833	amino acid
HFD81_01820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFD81_01825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFD81_01835	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_01875	COG0583	DNA-binding transcription factor activity
HFD81_01920	COG0517	IMP dehydrogenase activity
HFD81_01925	COG1983	PspC domain protein
HFD81_01935	COG1960	acyl-CoA dehydrogenase activity
HFD81_01950	COG0408	coproporphyrinogen oxidase activity
HFD81_01970	COG0513	Belongs to the DEAD box helicase family
HFD81_01980	COG1127	ABC transporter
HFD81_01985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFD81_01995	COG2854	intermembrane phospholipid transfer
HFD81_02005	COG0598	Magnesium transport protein CorA
HFD81_02015	COG0494	nUDIX hydrolase
HFD81_02020	COG1040	competence protein
HFD81_02025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFD81_02045	COG1946	Acyl-CoA thioesterase
HFD81_02050	COG1301	dicarboxylic acid transport
HFD81_02065	COG1959	2 iron, 2 sulfur cluster binding
HFD81_02070	COG1017	nitric oxide dioxygenase activity
HFD81_02070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD81_02075	COG0433	COG0433 Predicted ATPase
HFD81_02080	COG0626	cystathionine gamma-synthase activity
HFD81_02235	COG1960	acyl-CoA dehydrogenase activity
HFD81_02240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HFD81_02270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HFD81_02275	COG0339	signal peptide processing
HFD81_02280	COG0557	exoribonuclease II activity
HFD81_02325	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFD81_02330	COG2169	Transcriptional regulator
HFD81_02335	COG0697	spore germination
HFD81_02340	COG1295	ribonuclease BN
HFD81_02375	COG1702	phosphate starvation-inducible protein PhoH
HFD81_02385	COG0741	lytic transglycosylase activity
HFD81_02385	COG1196	nuclear chromosome segregation
HFD81_02385	COG0739	heme binding
HFD81_02415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFD81_02420	COG1183	phosphatidylcholine synthase activity
HFD81_02465	COG1960	acyl-CoA dehydrogenase activity
HFD81_02470	COG1309	transcriptional regulator
HFD81_02485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFD81_02490	COG1960	acyl-CoA dehydrogenase activity
HFD81_02510	COG2969	positive regulation of protein catabolic process
HFD81_02520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFD81_02535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFD81_02540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFD81_02560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFD81_02570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFD81_02575	COG1408	metallophosphoesterase
HFD81_02585	COG2199	diguanylate cyclase activity
HFD81_02645	COG1607	acyl-coa hydrolase
HFD81_02675	COG2350	Protein conserved in bacteria
HFD81_02685	COG0613	PHP domain protein
HFD81_02690	COG3781	membrane
HFD81_02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFD81_02705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFD81_02715	COG1862	Preprotein translocase
HFD81_02760	COG2205	protein histidine kinase activity
HFD81_02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HFD81_02785	COG0726	polysaccharide deacetylase
HFD81_02790	COG0463	Glycosyl transferase, family 2
HFD81_02795	COG0438	transferase activity, transferring glycosyl groups
HFD81_02860	COG0625	glutathione transferase activity
HFD81_02865	COG0583	DNA-binding transcription factor activity
HFD81_02870	COG1960	acyl-CoA dehydrogenase activity
HFD81_02875	COG1960	acyl-CoA dehydrogenase activity
HFD81_02885	COG2205	protein histidine kinase activity
HFD81_02890	COG0745	RESPONSE REGULATOR receiver
HFD81_02895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFD81_02915	COG2096	Adenosyltransferase
HFD81_02965	COG0285	dihydrofolate synthase activity
HFD81_02985	COG0450	alkyl hydroperoxide reductase
HFD81_03000	COG0477	Major facilitator Superfamily
HFD81_03005	COG1272	protein, Hemolysin III
HFD81_03040	COG0183	Belongs to the thiolase family
HFD81_03045	COG2207	Transcriptional regulator
HFD81_03065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD81_03085	COG0183	Belongs to the thiolase family
HFD81_03095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HFD81_03095	COG2885	chlorophyll binding
HFD81_03105	COG1690	Belongs to the RtcB family
HFD81_03110	COG0833	amino acid
HFD81_03120	COG2233	PERMEase
HFD81_03150	COG2094	Belongs to the DNA glycosylase MPG family
HFD81_03155	COG4772	TonB-dependent receptor
HFD81_03170	COG1902	pentaerythritol trinitrate reductase activity
HFD81_03185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD81_03190	COG0354	folic acid binding
HFD81_03200	COG3189	MarR family transcriptional regulator
HFD81_03205	COG2824	Alkylphosphonate utilization operon protein PhnA
HFD81_03210	COG3422	double-strand break repair
HFD81_03250	COG0840	transmembrane signaling receptor activity
HFD81_03270	COG5510	response to toxic substance
HFD81_03280	COG2832	Protein of unknown function (DUF454)
HFD81_03285	COG1376	ErfK ybiS ycfS ynhG family protein
HFD81_03325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFD81_03335	COG1289	transmembrane transporter activity
HFD81_03340	COG2814	Major facilitator Superfamily
HFD81_03360	COG1115	amino acid carrier protein
HFD81_03365	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFD81_03370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFD81_03375	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HFD81_03405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFD81_03415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFD81_03420	COG1077	Cell shape determining protein MreB Mrl
HFD81_03425	COG1792	Involved in formation and maintenance of cell shape
HFD81_03430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HFD81_03435	COG0424	maF-like protein
HFD81_03440	COG1530	ribonuclease E activity
HFD81_03450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD81_03460	COG0560	Phosphoserine phosphatase
HFD81_03470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD81_03495	COG2207	Transcriptional regulator
HFD81_03515	COG1113	amino acid transport
HFD81_03520	COG2828	Protein conserved in bacteria
HFD81_03525	COG0142	geranyltranstransferase activity
HFD81_03530	COG2315	Protein conserved in bacteria
HFD81_03545	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFD81_03565	COG2194	sulfuric ester hydrolase activity
HFD81_03570	COG0745	RESPONSE REGULATOR receiver
HFD81_03575	COG0642	Histidine kinase
HFD81_03585	COG0004	ammonium transporteR
HFD81_03590	COG0583	DNA-binding transcription factor activity
HFD81_03610	COG0525	valine-tRNA ligase activity
HFD81_03620	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_03630	COG0393	Putative heavy-metal-binding
HFD81_03635	COG0393	Putative heavy-metal-binding
HFD81_03640	COG1538	Outer membrane efflux protein
HFD81_03650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD81_03655	COG0671	phosphoesterase, PA-phosphatase related
HFD81_03685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HFD81_03700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFD81_03700	COG1648	precorrin-2 dehydrogenase activity
HFD81_03705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFD81_03710	COG1733	regulation of RNA biosynthetic process
HFD81_03720	COG0531	amino acid
HFD81_03735	COG0321	lipoyl(octanoyl) transferase activity
HFD81_03740	COG2921	Belongs to the UPF0250 family
HFD81_03780	COG2009	succinate dehydrogenase
HFD81_03785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HFD81_03790	COG1053	succinate dehydrogenase
HFD81_03795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFD81_03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD81_03840	COG2354	Protein conserved in bacteria
HFD81_03845	COG2321	neutral zinc metallopeptidase
HFD81_03880	COG2843	Capsule synthesis protein
HFD81_03895	COG0589	response to stress
HFD81_03915	COG0505	Belongs to the CarA family
HFD81_03940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFD81_03945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFD81_03995	COG0477	Major facilitator Superfamily
HFD81_04000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFD81_04015	COG1597	lipid kinase activity
HFD81_04020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFD81_04045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD81_04050	COG0584	glycerophosphoryl diester phosphodiesterase
HFD81_04070	COG0741	lytic transglycosylase activity
HFD81_04090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFD81_04105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD81_04130	COG0778	Nitroreductase
HFD81_04145	COG1929	Belongs to the glycerate kinase type-1 family
HFD81_04150	COG0243	molybdopterin cofactor binding
HFD81_04155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFD81_04160	COG3339	Conserved Protein
HFD81_04170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HFD81_04185	COG1113	amino acid transport
HFD81_04195	COG0019	diaminopimelate decarboxylase activity
HFD81_04205	COG1280	lysine exporter protein (LysE YggA)
HFD81_04210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HFD81_04240	COG0463	Glycosyl transferase, family 2
HFD81_04260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD81_04295	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFD81_04300	COG1136	(ABC) transporter
HFD81_04305	COG2333	competence protein COMEC
HFD81_04305	COG0658	competence protein
HFD81_04315	COG0616	signal peptide processing
HFD81_04315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFD81_04320	COG0596	Alpha beta hydrolase
HFD81_04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFD81_04335	COG0628	permease
HFD81_04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFD81_04390	COG0823	Involved in the tonB-independent uptake of proteins
HFD81_04410	COG0824	Thioesterase
HFD81_04415	COG1473	amidohydrolase
HFD81_04435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFD81_04435	COG0047	phosphoribosylformylglycinamidine synthase activity
HFD81_04440	COG2814	Major facilitator Superfamily
HFD81_04450	COG1024	Enoyl-CoA hydratase
HFD81_04455	COG1051	belongs to the nudix hydrolase family
HFD81_04455	COG1056	cytidyltransferase-related domain
HFD81_04465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFD81_04480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HFD81_04495	COG4625	pathogenesis
HFD81_04500	COG0583	DNA-binding transcription factor activity
HFD81_04505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFD81_04510	COG4208	sulfate ABC transporter
HFD81_04515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HFD81_04525	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFD81_04530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFD81_04535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFD81_04555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFD81_04570	COG0681	Belongs to the peptidase S26 family
HFD81_04585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFD81_04595	COG1381	Involved in DNA repair and RecF pathway recombination
HFD81_04600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFD81_04610	COG4221	oxidoreductase activity
HFD81_04640	COG0436	Aminotransferase
HFD81_04660	COG0556	nucleotide-excision repair
HFD81_04715	COG2070	2-Nitropropane dioxygenase
HFD81_04745	COG1215	transferase activity, transferring glycosyl groups
HFD81_04760	COG0415	Belongs to the DNA photolyase family
HFD81_04770	COG1252	NADH dehydrogenase
HFD81_04775	COG1686	Belongs to the peptidase S11 family
HFD81_04790	COG1187	pseudouridine synthase activity
HFD81_04815	COG0477	Major facilitator Superfamily
HFD81_04820	COG0583	DNA-binding transcription factor activity
HFD81_04835	COG0612	Peptidase, M16
HFD81_04870	COG0352	thiamine-phosphate diphosphorylase activity
HFD81_04905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD81_04920	COG1309	transcriptional regulator
HFD81_04930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFD81_04935	COG0076	glutamate decarboxylase activity
HFD81_04945	COG1522	sequence-specific DNA binding
HFD81_04950	COG3961	Belongs to the TPP enzyme family
HFD81_04955	COG1113	amino acid transport
HFD81_04960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFD81_04965	COG0573	inorganic phosphate transmembrane transporter activity
HFD81_04975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFD81_04980	COG0616	signal peptide processing
HFD81_05015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFD81_05020	COG1686	Belongs to the peptidase S11 family
HFD81_05045	COG0583	DNA-binding transcription factor activity
HFD81_05050	COG1067	ATP-dependent peptidase activity
HFD81_05095	COG1966	Carbon starvation protein
HFD81_05100	COG2879	small protein
HFD81_05135	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFD81_05135	COG2508	Transcriptional regulator
HFD81_05155	COG1113	amino acid transport
HFD81_05160	COG0583	DNA-binding transcription factor activity
HFD81_05165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD81_05170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD81_05180	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_05185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD81_05190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD81_05190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HFD81_05225	COG2814	Major facilitator Superfamily
HFD81_05230	COG4948	Mandelate Racemase Muconate Lactonizing
HFD81_05240	COG1309	transcriptional regulator
HFD81_05265	COG1741	Belongs to the pirin family
HFD81_05275	COG2964	Protein conserved in bacteria
HFD81_05290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD81_05295	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFD81_05300	COG4605	iron ion homeostasis
HFD81_05305	COG4604	ABC transporter, ATP-binding protein
HFD81_05310	COG4607	ABC-type enterochelin transport system periplasmic component
HFD81_05315	COG4774	siderophore transport
HFD81_05325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD81_05330	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFD81_05335	COG1535	isochorismatase
HFD81_05335	COG3433	isochorismatase activity
HFD81_05350	COG1132	(ABC) transporter
HFD81_05360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HFD81_05370	COG1169	isochorismate synthase
HFD81_05385	COG3739	integral membrane protein
HFD81_05420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFD81_05450	COG0308	aminopeptidase N
HFD81_05455	COG0512	Glutamine amidotransferase of anthranilate synthase
HFD81_05505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD81_05510	COG4197	protein conserved in bacteria, prophage-related
HFD81_05625	COG5410	chromosome segregation
HFD81_05795	COG0582	viral genome integration into host DNA
HFD81_05805	COG3104	oligopeptide transport
HFD81_05810	COG0174	glutamine synthetase
HFD81_05820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFD81_05855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFD81_05860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFD81_05865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFD81_05885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFD81_05890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HFD81_05895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HFD81_05910	COG1960	acyl-CoA dehydrogenase activity
HFD81_05915	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFD81_05920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD81_05930	COG2223	nitrite transmembrane transporter activity
HFD81_05940	COG0024	Methionine aminopeptidase
HFD81_05945	COG0052	Belongs to the universal ribosomal protein uS2 family
HFD81_05960	COG2207	Transcriptional regulator
HFD81_05985	COG2951	lytic endotransglycosylase activity
HFD81_05990	COG0772	Belongs to the SEDS family
HFD81_06005	COG0842	Transport permease protein
HFD81_06010	COG1131	(ABC) transporter
HFD81_06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD81_06070	COG4215	(ABC) transporter
HFD81_06075	COG4160	amino acid transport
HFD81_06080	COG4598	ABC transporter
HFD81_06090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFD81_06100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD81_06115	COG1720	tRNA m6t6A37 methyltransferase activity
HFD81_06135	COG0745	RESPONSE REGULATOR receiver
HFD81_06140	COG0642	Histidine kinase
HFD81_06150	COG0494	nUDIX hydrolase
HFD81_06160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFD81_06165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFD81_06170	COG3139	Protein of unknown function (DUF1315)
HFD81_06175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFD81_06180	COG1301	dicarboxylic acid transport
HFD81_06185	COG1960	acyl-CoA dehydrogenase activity
HFD81_06190	COG2819	hydrolase of the alpha beta superfamily
HFD81_06200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFD81_06210	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFD81_06215	COG1234	tRNA 3'-trailer cleavage
HFD81_06245	COG2363	Small membrane protein
HFD81_06265	COG0513	Belongs to the DEAD box helicase family
HFD81_06275	COG0778	Nitroreductase
HFD81_06615	COG1286	toxin biosynthetic process
HFD81_06640	COG4783	chaperone-mediated protein folding
HFD81_06645	COG1610	YqeY-like protein
HFD81_06745	COG3111	PFAM Bacterial OB fold (BOF) protein
HFD81_06770	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFD81_06775	COG0786	glutamate:sodium symporter activity
HFD81_06785	COG2186	Transcriptional regulator
HFD81_06835	COG0477	Major facilitator Superfamily
HFD81_06860	COG2985	domain, Protein
HFD81_06870	COG2995	paraquat-inducible protein a
HFD81_06875	COG3008	intermembrane lipid transfer
HFD81_06875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFD81_06885	COG1794	racemase activity, acting on amino acids and derivatives
HFD81_06970	COG0482	sulfurtransferase activity
HFD81_06990	COG3173	Aminoglycoside phosphotransferase
HFD81_07000	COG2433	Pfam Transposase IS66
HFD81_07040	COG1301	dicarboxylic acid transport
HFD81_07050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD81_07055	COG2011	ABC-type metal ion transport system permease component
HFD81_07060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD81_07065	COG1464	Belongs to the NlpA lipoprotein family
HFD81_07070	COG0151	Belongs to the GarS family
HFD81_07075	COG0138	bifunctional purine biosynthesis protein purh
HFD81_07080	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HFD81_07110	COG2308	Evidence 4 Homologs of previously reported genes of
HFD81_07120	COG1305	Transglutaminase-like
HFD81_07130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFD81_07135	COG0305	Participates in initiation and elongation during chromosome replication
HFD81_07160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFD81_07170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFD81_07175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFD81_07200	COG0726	polysaccharide deacetylase
HFD81_07200	COG1649	PFAM Uncharacterised BCR, COG1649
HFD81_07205	COG1215	transferase activity, transferring glycosyl groups
HFD81_07210	COG3658	cytochrome
HFD81_07220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD81_07235	COG0583	DNA-binding transcription factor activity
HFD81_07255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD81_07260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD81_07275	COG1960	acyl-CoA dehydrogenase activity
HFD81_07280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD81_07285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD81_07310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HFD81_07315	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HFD81_07325	COG2205	protein histidine kinase activity
HFD81_07330	COG0745	RESPONSE REGULATOR receiver
HFD81_07335	COG0174	glutamine synthetase
HFD81_07355	COG0729	surface antigen
HFD81_07380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFD81_07385	COG2814	Major facilitator Superfamily
HFD81_07400	COG0583	DNA-binding transcription factor activity
HFD81_07415	COG1187	pseudouridine synthase activity
HFD81_07435	COG0802	atpase or kinase
HFD81_07440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFD81_07450	COG1923	regulation of RNA biosynthetic process
HFD81_07455	COG0697	spore germination
HFD81_07470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD81_07480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFD81_07485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFD81_07485	COG0519	Catalyzes the synthesis of GMP from XMP
HFD81_07490	COG4302	ethanolamine ammonia-lyase activity
HFD81_07495	COG4303	Ethanolamine ammonia lyase large subunit
HFD81_07500	COG0531	amino acid
HFD81_07520	COG1454	alcohol dehydrogenase
HFD81_07525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFD81_07535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFD81_07555	COG0308	aminopeptidase N
HFD81_07565	COG4221	oxidoreductase activity
HFD81_07575	COG1605	Chorismate mutase
HFD81_07590	COG1309	transcriptional regulator
HFD81_07600	COG0668	transmembrane transport
HFD81_07635	COG4773	Receptor
HFD81_07655	COG0488	(ABC) transporter
HFD81_07660	COG0589	response to stress
HFD81_07685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFD81_07695	COG3135	benzoate transporter
HFD81_07700	COG1522	sequence-specific DNA binding
HFD81_07710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFD81_07715	COG0583	DNA-binding transcription factor activity
HFD81_07725	COG0183	Belongs to the thiolase family
HFD81_07735	COG2030	dehydratase
HFD81_07755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFD81_07765	COG0824	Thioesterase
HFD81_07770	COG1454	alcohol dehydrogenase
HFD81_07780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFD81_07800	COG0069	glutamate synthase activity
HFD81_07820	COG2814	Major facilitator Superfamily
HFD81_07835	COG0511	ligase activity, forming carbon-carbon bonds
HFD81_07855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD81_07855	COG1116	anion transmembrane transporter activity
HFD81_07860	COG0745	RESPONSE REGULATOR receiver
HFD81_07870	COG2146	nitrite reductase [NAD(P)H] activity
HFD81_07870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD81_07875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD81_07880	COG0243	molybdopterin cofactor binding
HFD81_07890	COG0243	molybdopterin cofactor binding
HFD81_07895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFD81_07910	COG0315	cyclic pyranopterin monophosphate synthase activity
HFD81_07910	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFD81_07915	COG0303	'Molybdopterin
HFD81_07925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD81_07930	COG0697	spore germination
HFD81_07950	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HFD81_07955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFD81_08010	COG2204	response regulator
HFD81_08015	COG3852	Histidine kinase
HFD81_08035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFD81_08040	COG0575	Belongs to the CDS family
HFD81_08075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD81_08090	COG2137	regulation of response to DNA damage stimulus
HFD81_08100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFD81_08105	COG1011	Hydrolase
HFD81_08130	COG1522	sequence-specific DNA binding
HFD81_08140	COG1113	amino acid transport
HFD81_08155	COG0659	secondary active sulfate transmembrane transporter activity
HFD81_08160	COG2135	peptidase activity
HFD81_08175	COG5001	Diguanylate cyclase
HFD81_08175	COG3300	MHYT domain
HFD81_08195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFD81_08195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFD81_08195	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFD81_08200	COG1105	Belongs to the carbohydrate kinase PfkB family
HFD81_08205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFD81_08205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFD81_08235	COG0024	Methionine aminopeptidase
HFD81_08240	COG0583	DNA-binding transcription factor activity
HFD81_08250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFD81_08255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFD81_08260	COG0516	GMP reductase activity
HFD81_08260	COG0517	IMP dehydrogenase activity
HFD81_08285	COG0552	protein localization to endoplasmic reticulum
HFD81_08295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HFD81_08310	COG4890	Cyd operon protein YbgT
HFD81_08315	COG1294	oxidase, subunit
HFD81_08330	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFD81_08340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFD81_08345	COG4774	siderophore transport
HFD81_08360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFD81_08365	COG0569	domain protein
HFD81_08370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFD81_08400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HFD81_08405	COG0542	response to heat
HFD81_08430	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD81_08430	COG1902	pentaerythritol trinitrate reductase activity
HFD81_08475	COG2323	membrane
HFD81_08480	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HFD81_08490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD81_08495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD81_08500	COG0183	Belongs to the thiolase family
HFD81_08505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFD81_08510	COG0596	Alpha beta hydrolase
HFD81_08515	COG2271	Major facilitator Superfamily
HFD81_08520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFD81_08525	COG3485	protocatechuate 3,4-dioxygenase
HFD81_08530	COG3485	protocatechuate 3,4-dioxygenase
HFD81_08535	COG0710	3-dehydroquinate dehydratase activity
HFD81_08540	COG3420	alginic acid biosynthetic process
HFD81_08545	COG3659	wide pore channel activity
HFD81_08550	COG4993	Dehydrogenase
HFD81_08560	COG2391	methyltransferase activity
HFD81_08575	COG1414	Transcriptional regulator
HFD81_08580	COG0583	DNA-binding transcription factor activity
HFD81_08585	COG1960	acyl-CoA dehydrogenase activity
HFD81_08610	COG2814	Major facilitator Superfamily
HFD81_08620	COG0154	amidase activity
HFD81_08640	COG4638	Rieske (2fe-2S)
HFD81_08650	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_08660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD81_08670	COG3733	amine oxidase
HFD81_08680	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_08690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD81_08695	COG0183	Belongs to the thiolase family
HFD81_08700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD81_08705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD81_08715	COG4829	muconolactone delta-isomerase
HFD81_08720	COG4948	Mandelate Racemase Muconate Lactonizing
HFD81_08725	COG0583	DNA-binding transcription factor activity
HFD81_08735	COG2186	Transcriptional regulator
HFD81_08755	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_08775	COG1960	acyl-CoA dehydrogenase activity
HFD81_08780	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_08785	COG3829	transcription factor binding
HFD81_08795	COG3162	membrane
HFD81_08810	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_08825	COG0753	catalase activity
HFD81_08845	COG1846	Transcriptional regulator
HFD81_08850	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD81_08850	COG1902	pentaerythritol trinitrate reductase activity
HFD81_08860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFD81_08890	COG1309	transcriptional regulator
HFD81_08900	COG1335	isochorismatase
HFD81_08905	COG0583	DNA-binding transcription factor activity
HFD81_08915	COG0475	glutathione-regulated potassium exporter activity
HFD81_08915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD81_08925	COG1473	amidohydrolase
HFD81_08935	COG2831	hemolysin activation secretion protein
HFD81_08940	COG3210	domain, Protein
HFD81_08970	COG2188	Transcriptional regulator
HFD81_08985	COG0583	DNA-binding transcription factor activity
HFD81_09015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFD81_09035	COG1566	PFAM secretion protein HlyD family protein
HFD81_09050	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_09055	COG0129	dihydroxy-acid dehydratase activity
HFD81_09065	COG0583	DNA-binding transcription factor activity
HFD81_09070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFD81_09080	COG2084	Dehydrogenase
HFD81_09085	COG2207	Transcriptional regulator
HFD81_09100	COG1064	alcohol dehydrogenase
HFD81_09115	COG1120	ATPase activity
HFD81_09135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFD81_09250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HFD81_09300	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_09315	COG2207	Transcriptional regulator
HFD81_09325	COG2205	protein histidine kinase activity
HFD81_09330	COG0745	RESPONSE REGULATOR receiver
HFD81_09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD81_09340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFD81_09345	COG1538	Outer membrane efflux protein
HFD81_09355	COG2072	flavoprotein involved in K transport
HFD81_09375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD81_09395	COG3539	Fimbrial protein
HFD81_09425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HFD81_09435	COG0753	catalase activity
HFD81_09450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFD81_09515	COG3433	isochorismatase activity
HFD81_09515	COG1535	isochorismatase
HFD81_09520	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_09525	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFD81_09530	COG4149	molybdate abc transporter
HFD81_09535	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFD81_09545	COG4638	Rieske (2fe-2S)
HFD81_09550	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFD81_09555	COG0543	2 iron, 2 sulfur cluster binding
HFD81_09555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD81_09580	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_09595	COG2207	Transcriptional regulator
HFD81_09605	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_09610	COG2610	gluconate transmembrane transporter activity
HFD81_09620	COG0583	DNA-binding transcription factor activity
HFD81_09630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD81_09635	COG2031	fatty acid transporter
HFD81_09640	COG0183	Belongs to the thiolase family
HFD81_09645	COG0583	DNA-binding transcription factor activity
HFD81_09650	COG0583	DNA-binding transcription factor activity
HFD81_09665	COG1027	Aspartate ammonia-lyase
HFD81_09675	COG0477	Major facilitator Superfamily
HFD81_09695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD81_09700	COG4521	taurine ABC transporter
HFD81_09715	COG2188	Transcriptional regulator
HFD81_09725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFD81_09730	COG1733	regulation of RNA biosynthetic process
HFD81_09735	COG3708	Transcriptional regulator
HFD81_09735	COG2207	Transcriptional regulator
HFD81_09750	COG0730	response to heat
HFD81_09760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD81_09760	COG3453	Protein conserved in bacteria
HFD81_09770	COG3781	membrane
HFD81_09775	COG1063	alcohol dehydrogenase
HFD81_09785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD81_09790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFD81_09795	COG0022	dehydrogenase e1 component
HFD81_09800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFD81_09805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFD81_09820	COG3706	GGDEF domain
HFD81_09835	COG0133	tryptophan synthase activity
HFD81_09845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFD81_09880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFD81_09965	COG0842	Transport permease protein
HFD81_09970	COG0842	Transport permease protein
HFD81_09975	COG1131	(ABC) transporter
HFD81_09990	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD81_09995	COG4773	Receptor
HFD81_10015	COG0730	response to heat
HFD81_10020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFD81_10040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFD81_10095	COG4264	IucA IucC family
HFD81_10100	COG4264	IucA IucC family
HFD81_10120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFD81_10135	COG1960	acyl-CoA dehydrogenase activity
HFD81_10140	COG1960	acyl-CoA dehydrogenase activity
HFD81_10145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFD81_10150	COG2207	Transcriptional regulator
HFD81_10155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFD81_10160	COG0776	regulation of translation
HFD81_10185	COG0822	iron-sulfur transferase activity
HFD81_10190	COG0316	Belongs to the HesB IscA family
HFD81_10220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFD81_10240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFD81_10245	COG0702	epimerase
HFD81_10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFD81_10290	COG0339	signal peptide processing
HFD81_10340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFD81_10345	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFD81_10375	COG0776	regulation of translation
HFD81_10440	COG0084	hydrolase, TatD family'
HFD81_10460	COG1663	tetraacyldisaccharide 4'-kinase activity
HFD81_10465	COG1132	(ABC) transporter
HFD81_10475	COG0811	peptide transport
HFD81_10480	COG1475	DNA binding
HFD81_10485	COG1192	Involved in chromosome partitioning
HFD81_10495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFD81_10510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFD81_10515	COG0191	fructose-bisphosphate aldolase activity
HFD81_10535	COG0424	maF-like protein
HFD81_10540	COG2850	peptidyl-arginine hydroxylation
HFD81_10550	COG0640	Transcriptional regulator
HFD81_10560	COG3619	membrane
HFD81_10565	COG3122	Protein conserved in bacteria
HFD81_10570	COG1132	(ABC) transporter
HFD81_10590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HFD81_10595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFD81_10605	COG0506	proline dehydrogenase activity
HFD81_10605	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFD81_10605	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFD81_10610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HFD81_10625	COG3698	Phosphodiester glycosidase
HFD81_10635	COG2353	YceI-like domain
HFD81_10645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFD81_10690	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFD81_10690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HFD81_10715	COG3539	Fimbrial protein
HFD81_10720	COG3121	Chaperone
HFD81_10745	COG0697	spore germination
HFD81_10755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFD81_10765	COG0583	DNA-binding transcription factor activity
HFD81_10785	COG1309	transcriptional regulator
HFD81_10800	COG1522	sequence-specific DNA binding
HFD81_10810	COG1126	abc transporter atp-binding protein
HFD81_10815	COG0765	amino acid transport
HFD81_10820	COG0765	amino acid transport
HFD81_10850	COG1464	Belongs to the NlpA lipoprotein family
HFD81_10860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD81_10865	COG2011	ABC-type metal ion transport system permease component
HFD81_10870	COG0012	GTP binding
HFD81_10895	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFD81_10935	COG0386	Belongs to the glutathione peroxidase family
HFD81_10945	COG0436	Aminotransferase
HFD81_10985	COG3634	alkyl hydroperoxide reductase activity
HFD81_11000	COG0583	DNA-binding transcription factor activity
HFD81_11005	COG0798	PFAM Bile acid sodium symporter
HFD81_11010	COG0640	Transcriptional regulator
HFD81_11025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFD81_11035	COG0583	DNA-binding transcription factor activity
HFD81_11045	COG1953	Uracil, thiamine, allantoin
HFD81_11055	COG2175	clavaminate synthase activity
HFD81_11060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD81_11065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HFD81_11070	COG4521	taurine ABC transporter
HFD81_11080	COG0477	Major facilitator Superfamily
HFD81_11105	COG1271	oxidase subunit
HFD81_11110	COG1294	oxidase, subunit
HFD81_11120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD81_11140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HFD81_11160	COG3052	prosthetic group binding
HFD81_11165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HFD81_11175	COG2814	Major facilitator Superfamily
HFD81_11195	COG1346	cytolysis
HFD81_11205	COG0583	DNA-binding transcription factor activity
HFD81_11210	COG0625	glutathione transferase activity
HFD81_11215	COG0625	glutathione transferase activity
HFD81_11220	COG0583	DNA-binding transcription factor activity
HFD81_11235	COG1045	serine acetyltransferase
HFD81_11240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFD81_11245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFD81_11255	COG1280	lysine exporter protein (LysE YggA)
HFD81_11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD81_11275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD81_11280	COG1126	abc transporter atp-binding protein
HFD81_11285	COG0765	amino acid transport
HFD81_11290	COG0765	amino acid transport
HFD81_11310	COG2205	protein histidine kinase activity
HFD81_11310	COG0784	Response regulator, receiver
HFD81_11330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD81_11350	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_11400	COG0583	DNA-binding transcription factor activity
HFD81_11420	COG0318	PFAM AMP-dependent synthetase and ligase
HFD81_11425	COG1309	transcriptional regulator
HFD81_11430	COG1960	acyl-CoA dehydrogenase activity
HFD81_11435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFD81_11440	COG1024	Enoyl-CoA hydratase
HFD81_11445	COG4770	biotin carboxylase activity
HFD81_11455	COG0583	DNA-binding transcription factor activity
HFD81_11470	COG1960	acyl-CoA dehydrogenase activity
HFD81_11480	COG2814	Major facilitator Superfamily
HFD81_11490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD81_11495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD81_11500	COG2814	Major facilitator Superfamily
HFD81_11505	COG1960	acyl-CoA dehydrogenase activity
HFD81_11510	COG1024	Enoyl-CoA hydratase
HFD81_11515	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_11520	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD81_11525	COG0183	Belongs to the thiolase family
HFD81_11535	COG2814	Major facilitator Superfamily
HFD81_11545	COG1024	Enoyl-CoA hydratase
HFD81_11560	COG1960	acyl-CoA dehydrogenase activity
HFD81_11565	COG2814	Major facilitator Superfamily
HFD81_11570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFD81_11575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HFD81_11590	COG3842	ATPase activity
HFD81_11595	COG1840	ABC-type Fe3 transport system, periplasmic component
HFD81_11605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD81_11610	COG1414	Transcriptional regulator
HFD81_11620	COG0583	DNA-binding transcription factor activity
HFD81_11625	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFD81_11630	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_11640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFD81_11650	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_11655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD81_11660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD81_11665	COG2267	carboxylic ester hydrolase activity
HFD81_11685	COG3038	cytochrome b561
HFD81_11690	COG0753	catalase activity
HFD81_11725	COG2050	protein possibly involved in aromatic compounds catabolism
HFD81_11735	COG3327	negative regulation of DNA-templated transcription, initiation
HFD81_11740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFD81_11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD81_11755	COG1024	Enoyl-CoA hydratase
HFD81_11760	COG1024	Enoyl-CoA hydratase
HFD81_11765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD81_11770	COG2151	metal-sulfur cluster biosynthetic enzyme
HFD81_11775	COG3396	Phenylacetate-CoA oxygenase
HFD81_11780	COG3460	Phenylacetate-CoA oxygenase
HFD81_11785	COG3396	Phenylacetate-CoA oxygenase
HFD81_11790	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_11790	COG2030	dehydratase
HFD81_11795	COG1760	l-serine dehydratase
HFD81_11800	COG0531	amino acid
HFD81_11805	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_11820	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD81_11830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD81_11850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD81_11860	COG0789	Transcriptional regulator
HFD81_11875	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HFD81_11890	COG2807	transmembrane transport
HFD81_11895	COG0590	tRNA wobble adenosine to inosine editing
HFD81_12010	COG1116	anion transmembrane transporter activity
HFD81_12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD81_12025	COG0864	Transcriptional regulator
HFD81_12045	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD81_12050	COG0439	Biotin carboxylase
HFD81_12065	COG1063	alcohol dehydrogenase
HFD81_12075	COG1309	transcriptional regulator
HFD81_12095	COG0038	chloride channel
HFD81_12100	COG4770	biotin carboxylase activity
HFD81_12120	COG1914	H( )-stimulated, divalent metal cation uptake system
HFD81_12125	COG0583	DNA-binding transcription factor activity
HFD81_12140	COG3209	COG3209 Rhs family protein
HFD81_12145	COG3501	Rhs element vgr protein
HFD81_12180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD81_12200	COG2814	Major facilitator Superfamily
HFD81_12210	COG1560	Kdo2-lipid A biosynthetic process
HFD81_12220	COG5006	permease, DMT superfamily
HFD81_12225	COG1522	sequence-specific DNA binding
HFD81_12240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFD81_12250	COG4122	O-methyltransferase activity
HFD81_12280	COG1538	Outer membrane efflux protein
HFD81_12290	COG1137	ATPase activity
HFD81_12295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFD81_12305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HFD81_12310	COG0517	IMP dehydrogenase activity
HFD81_12310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFD81_12350	COG2814	Major facilitator Superfamily
HFD81_12385	COG1278	Cold shock
HFD81_12390	COG1280	lysine exporter protein (LysE YggA)
HFD81_12425	COG1570	exodeoxyribonuclease VII activity
HFD81_12475	COG0583	DNA-binding transcription factor activity
HFD81_12480	COG4638	Rieske (2fe-2S)
HFD81_12485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFD81_12490	COG0543	2 iron, 2 sulfur cluster binding
HFD81_12490	COG0633	Ferredoxin
HFD81_12495	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_12500	COG3135	benzoate transporter
HFD81_12505	COG2814	Major facilitator Superfamily
HFD81_12520	COG1643	Atp-dependent helicase
HFD81_12525	COG0450	alkyl hydroperoxide reductase
HFD81_12535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HFD81_12545	COG3634	alkyl hydroperoxide reductase activity
HFD81_12565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFD81_12570	COG0625	glutathione transferase activity
HFD81_12580	COG2885	chlorophyll binding
HFD81_12615	COG0542	response to heat
HFD81_12630	COG1765	OsmC-like protein
HFD81_12645	COG0667	Aldo Keto reductase
HFD81_12660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HFD81_12670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFD81_12680	COG0527	aspartate kinase activity
HFD81_12690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFD81_12700	COG3038	cytochrome b561
HFD81_12705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFD81_12710	COG2252	PERMEase
HFD81_12720	COG2072	flavoprotein involved in K transport
HFD81_12735	COG1741	Belongs to the pirin family
HFD81_12740	COG1309	transcriptional regulator
HFD81_12750	COG0300	oxidoreductase activity
HFD81_12855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFD81_12885	COG1113	amino acid transport
HFD81_12905	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_12925	COG0531	amino acid
HFD81_12935	COG1113	amino acid transport
HFD81_12975	COG3209	COG3209 Rhs family protein
HFD81_12980	COG3501	Rhs element vgr protein
HFD81_13005	COG4269	membrane
HFD81_13020	COG1902	pentaerythritol trinitrate reductase activity
HFD81_13020	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD81_13030	COG4251	negative regulation of phosphorylation
HFD81_13030	COG5001	Diguanylate cyclase
HFD81_13030	COG3706	GGDEF domain
HFD81_13030	COG2203	Gaf domain
HFD81_13040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD81_13060	COG4172	Belongs to the ABC transporter superfamily
HFD81_13065	COG4239	(ABC) transporter, permease
HFD81_13070	COG4174	ABC transporter (Permease)
HFD81_13080	COG0741	lytic transglycosylase activity
HFD81_13080	COG1388	LysM domain
HFD81_13080	COG0741	lytic transglycosylase activity
HFD81_13080	COG1388	LysM domain
HFD81_13085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD81_13125	COG0583	DNA-binding transcription factor activity
HFD81_13130	COG1279	arginine transmembrane transporter activity
HFD81_13150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD81_13155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD81_13160	COG0006	proline dipeptidase activity
HFD81_13245	COG1196	nuclear chromosome segregation
HFD81_13245	COG0741	lytic transglycosylase activity
HFD81_13245	COG0739	heme binding
HFD81_13305	COG4695	Portal protein
HFD81_13400	COG0305	Participates in initiation and elongation during chromosome replication
HFD81_13415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD81_13465	COG2194	sulfuric ester hydrolase activity
HFD81_13510	COG0739	heme binding
HFD81_13835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFD81_13860	COG3384	dioxygenase
HFD81_13870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFD81_13875	COG2878	Part of a membrane complex involved in electron transport
HFD81_13880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFD81_13905	COG0768	penicillin binding
HFD81_13910	COG0742	ribosomal rna small subunit methyltransferase
HFD81_13925	COG0830	nickel cation binding
HFD81_13935	COG0804	urea catabolic process
HFD81_13975	COG1253	flavin adenine dinucleotide binding
HFD81_13980	COG2851	Citrate transporter
HFD81_14030	COG1773	rubredoxin
HFD81_14035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD81_14045	COG0583	DNA-binding transcription factor activity
HFD81_14070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HFD81_14075	COG4181	ATPase activity
HFD81_14120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HFD81_14140	COG0306	phosphate transporter
HFD81_14150	COG3958	Transketolase
HFD81_14155	COG3959	Transketolase, thiamine diphosphate binding domain
HFD81_14160	COG2271	Major facilitator Superfamily
HFD81_14165	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_14170	COG0583	DNA-binding transcription factor activity
HFD81_14185	COG2223	nitrite transmembrane transporter activity
HFD81_14190	COG2207	Transcriptional regulator
HFD81_14195	COG2066	Belongs to the glutaminase family
HFD81_14200	COG0242	peptide deformylase activity
HFD81_14205	COG0477	Major facilitator Superfamily
HFD81_14215	COG0028	Belongs to the TPP enzyme family
HFD81_14230	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_14235	COG2267	carboxylic ester hydrolase activity
HFD81_14245	COG2271	Major facilitator Superfamily
HFD81_14250	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD81_14260	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_14280	COG1414	Transcriptional regulator
HFD81_14295	COG1024	Enoyl-CoA hydratase
HFD81_14305	COG1215	transferase activity, transferring glycosyl groups
HFD81_14310	COG0726	polysaccharide deacetylase
HFD81_14310	COG1649	PFAM Uncharacterised BCR, COG1649
HFD81_14320	COG4681	YaeQ
HFD81_14330	COG0523	cobalamin synthesis protein
HFD81_14340	COG1607	acyl-coa hydrolase
HFD81_14350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD81_14355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD81_14360	COG1309	transcriptional regulator
HFD81_14385	COG2040	homocysteine
HFD81_14390	COG0531	amino acid
HFD81_14445	COG1595	DNA-templated transcription, initiation
HFD81_14455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD81_14460	COG0477	Major facilitator Superfamily
HFD81_14480	COG0084	hydrolase, TatD family'
HFD81_14515	COG0629	single-stranded DNA binding
HFD81_14570	COG0582	viral genome integration into host DNA
HFD81_14590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFD81_14675	COG0592	DNA-directed DNA polymerase activity
HFD81_14715	COG2026	Addiction module toxin, RelE StbE family
HFD81_14910	COG1484	DNA-dependent DNA replication
HFD81_15025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD81_15060	COG0405	Gamma-glutamyltransferase
HFD81_15065	COG2814	Major facilitator Superfamily
HFD81_15075	COG2050	protein possibly involved in aromatic compounds catabolism
HFD81_15090	COG1090	epimerase
HFD81_15110	COG0420	3'-5' exonuclease activity
HFD81_15135	COG0735	belongs to the Fur family
HFD81_15140	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFD81_15160	COG0121	glutamine amidotransferase
HFD81_15175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFD81_15185	COG0210	DNA helicase
HFD81_15190	COG2885	chlorophyll binding
HFD81_15195	COG0204	Acyl-transferase
HFD81_15210	COG2894	cell division
HFD81_15230	COG1280	lysine exporter protein (LysE YggA)
HFD81_15235	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFD81_15235	COG1674	ftsk spoiiie
HFD81_15240	COG0492	ferredoxin-NADP+ reductase activity
HFD81_15245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HFD81_15255	COG0456	acetyltransferase
HFD81_15315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HFD81_15315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFD81_15335	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_15355	COG0473	3-isopropylmalate dehydrogenase activity
HFD81_15360	COG0583	DNA-binding transcription factor activity
HFD81_15380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFD81_15405	COG0564	pseudouridine synthase activity
HFD81_15415	COG0358	DNA primase activity
HFD81_15430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HFD81_15460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFD81_15490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFD81_15500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFD81_15500	COG0352	thiamine-phosphate diphosphorylase activity
HFD81_15500	COG0351	phosphomethylpyrimidine kinase
HFD81_15510	COG1652	LysM domain
HFD81_15535	COG1399	metal-binding, possibly nucleic acid-binding protein
HFD81_15540	COG3101	peptidyl-lysine hydroxylation
HFD81_15545	COG0009	L-threonylcarbamoyladenylate synthase
HFD81_15550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HFD81_15555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFD81_15570	COG4106	trans-aconitate 2-methyltransferase activity
HFD81_15585	COG2226	methyltransferase
HFD81_15585	COG0596	Alpha beta hydrolase
HFD81_15585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD81_15590	COG1877	trehalose-phosphatase activity
HFD81_15595	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HFD81_15600	COG2223	nitrite transmembrane transporter activity
HFD81_15620	COG1196	nuclear chromosome segregation
HFD81_15630	COG0730	response to heat
HFD81_15645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFD81_15655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFD81_15705	COG0489	protein tyrosine kinase activity
HFD81_15715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD81_15715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD81_15745	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HFD81_15750	COG2081	HI0933 family
HFD81_15760	COG0668	transmembrane transport
HFD81_15780	COG0583	DNA-binding transcription factor activity
HFD81_15800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFD81_15805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFD81_15835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HFD81_15870	COG2205	protein histidine kinase activity
HFD81_15875	COG0745	RESPONSE REGULATOR receiver
HFD81_15895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFD81_15905	COG2205	protein histidine kinase activity
HFD81_15975	COG4993	Dehydrogenase
HFD81_15995	COG0384	phenazine biosynthesis protein PhzF
HFD81_16015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD81_16030	COG0583	DNA-binding transcription factor activity
HFD81_16050	COG1473	amidohydrolase
HFD81_16060	COG0583	DNA-binding transcription factor activity
HFD81_16075	COG0583	DNA-binding transcription factor activity
HFD81_16080	COG1053	succinate dehydrogenase
HFD81_16090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFD81_16095	COG2814	Major facilitator Superfamily
HFD81_16100	COG1960	acyl-CoA dehydrogenase activity
HFD81_16105	COG0583	DNA-binding transcription factor activity
HFD81_16110	COG1063	alcohol dehydrogenase
HFD81_16140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFD81_16145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFD81_16150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFD81_16165	COG3667	copper resistance
HFD81_16170	COG2132	Multicopper oxidase
HFD81_16180	COG0561	phosphatase activity
HFD81_16185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFD81_16210	COG1214	PFAM Peptidase M22, glycoprotease
HFD81_16260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFD81_16270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFD81_16275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFD81_16280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFD81_16340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFD81_16350	COG1846	Transcriptional regulator
HFD81_16355	COG1764	response to oxidative stress
HFD81_16395	COG0037	tRNA processing
HFD81_16405	COG0248	Ppx GppA phosphatase
HFD81_16435	COG0072	phenylalanine-tRNA ligase activity
HFD81_16475	COG1238	metal cluster binding
HFD81_16480	COG0625	glutathione transferase activity
HFD81_16495	COG0318	PFAM AMP-dependent synthetase and ligase
HFD81_16500	COG3028	Belongs to the UPF0307 family
HFD81_16505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFD81_16525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFD81_16530	COG0617	tRNA 3'-terminal CCA addition
HFD81_16535	COG1555	photosystem II stabilization
HFD81_16540	COG3956	TIGRFAM MazG family protein
HFD81_16550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFD81_16570	COG0784	Response regulator, receiver
HFD81_16570	COG5002	protein histidine kinase activity
HFD81_16570	COG2205	protein histidine kinase activity
HFD81_16575	COG1024	Enoyl-CoA hydratase
HFD81_16580	COG2084	Dehydrogenase
HFD81_16585	COG3622	Belongs to the hyi family
HFD81_16615	COG0697	spore germination
HFD81_16625	COG2814	Major facilitator Superfamily
HFD81_16630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFD81_16640	COG0583	DNA-binding transcription factor activity
HFD81_16650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFD81_16665	COG0084	hydrolase, TatD family'
HFD81_16680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFD81_16710	COG0440	acetolactate synthase activity
HFD81_16715	COG0028	Belongs to the TPP enzyme family
HFD81_16740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD81_16745	COG1136	(ABC) transporter
HFD81_16745	COG0577	efflux transmembrane transporter activity
HFD81_16750	COG1538	Outer membrane efflux protein
HFD81_16765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HFD81_16770	COG1162	GTPase activity
HFD81_16780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFD81_16800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFD81_16805	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_16845	COG2986	histidine ammonia-lyase
HFD81_16860	COG0318	PFAM AMP-dependent synthetase and ligase
HFD81_16870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFD81_16915	COG1426	Protein conserved in bacteria
HFD81_16950	COG0793	Belongs to the peptidase S41A family
HFD81_16965	COG2267	carboxylic ester hydrolase activity
HFD81_16975	COG1012	belongs to the aldehyde dehydrogenase family
HFD81_16980	COG3265	gluconokinase activity
HFD81_16990	COG0800	Aldolase
HFD81_17000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFD81_17005	COG0857	belongs to the CobB CobQ family
HFD81_17005	COG0280	phosphate acetyltransferase
HFD81_17010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFD81_17010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFD81_17030	COG0740	serine-type endopeptidase activity
HFD81_17040	COG4774	siderophore transport
HFD81_17050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFD81_17060	COG2813	Specifically methylates the guanine in position
HFD81_17060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD81_17165	COG0788	formyltetrahydrofolate deformylase activity
HFD81_17190	COG4651	solute:proton antiporter activity
HFD81_17190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD81_17210	COG0724	RNA recognition motif
HFD81_17215	COG0210	DNA helicase
HFD81_17240	COG1733	regulation of RNA biosynthetic process
HFD81_17250	COG2900	Belongs to the SlyX family
HFD81_17260	COG1280	lysine exporter protein (LysE YggA)
HFD81_17265	COG1560	Kdo2-lipid A biosynthetic process
HFD81_17275	COG1301	dicarboxylic acid transport
HFD81_17330	COG0473	3-isopropylmalate dehydrogenase activity
HFD81_17395	COG0583	DNA-binding transcription factor activity
HFD81_17405	COG0625	glutathione transferase activity
HFD81_17410	COG2378	regulation of single-species biofilm formation
HFD81_17415	COG0546	phosphoglycolate phosphatase activity
HFD81_17430	COG1530	ribonuclease E activity
HFD81_17435	COG0318	PFAM AMP-dependent synthetase and ligase
HFD81_17450	COG0583	DNA-binding transcription factor activity
HFD81_17455	COG4221	oxidoreductase activity
HFD81_17460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFD81_17470	COG0534	Mate efflux family protein
HFD81_17485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HFD81_17525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HFD81_17530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD81_17545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFD81_17555	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HFD81_17555	COG0644	oxidoreductase
HFD81_17560	COG0425	Belongs to the sulfur carrier protein TusA family
HFD81_17565	COG4535	Mg2 and Co2 transporter CorC
HFD81_17575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD81_17595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFD81_17600	COG0475	glutathione-regulated potassium exporter activity
HFD81_17600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD81_17605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFD81_17615	COG0484	heat shock protein binding
HFD81_17620	COG0789	Transcriptional regulator
HFD81_17625	COG0598	Magnesium transport protein CorA
HFD81_17645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFD81_17650	COG1074	ATP-dependent DNA helicase activity
HFD81_17655	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HFD81_17675	COG2226	methyltransferase
HFD81_17690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD81_17695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFD81_17710	COG2111	Na H antiporter
HFD81_17710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFD81_17715	COG1006	Multisubunit Na H antiporter MnhC subunit
HFD81_17720	COG0651	ATP synthesis coupled electron transport
HFD81_17730	COG2212	antiporter activity
HFD81_17750	COG0195	Participates in both transcription termination and antitermination
HFD81_17800	COG0237	dephospho-CoA kinase activity
HFD81_17810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFD81_17825	COG0497	DNA recombination
HFD81_17835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFD81_17865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFD81_17865	COG2169	Transcriptional regulator
HFD81_17870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFD81_17935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFD81_17950	COG0326	Molecular chaperone. Has ATPase activity
HFD81_17965	COG2056	Na+-H+ antiporter family
HFD81_17970	COG0596	Alpha beta hydrolase
HFD81_18065	COG0546	phosphoglycolate phosphatase activity
HFD81_18070	COG1716	ATPase activity
HFD81_18115	COG0181	hydroxymethylbilane synthase activity
HFD81_18125	COG3275	phosphorelay sensor kinase activity
HFD81_18145	COG1538	Outer membrane efflux protein
HFD81_18150	COG0697	spore germination
HFD81_18175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFD81_18180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFD81_18185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFD81_18190	COG0772	Belongs to the SEDS family
HFD81_18215	COG4974	Belongs to the 'phage' integrase family
HFD81_18220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD81_18230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFD81_18240	COG2197	response regulator
HFD81_18255	COG0793	Belongs to the peptidase S41A family
HFD81_18260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFD81_18265	COG0795	lipopolysaccharide-transporting ATPase activity
HFD81_18305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFD81_18305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFD81_18315	COG0004	ammonium transporteR
HFD81_18320	COG0347	Belongs to the P(II) protein family
HFD81_18330	COG0606	chelatase, subunit chli
HFD81_18400	COG0659	secondary active sulfate transmembrane transporter activity
HFD81_18405	COG0589	response to stress
HFD81_18445	COG0606	chelatase, subunit chli
HFD81_18450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD81_18460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD81_18475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HFD81_18490	COG0318	PFAM AMP-dependent synthetase and ligase
HFD81_18500	COG0477	Major facilitator Superfamily
HFD81_18505	COG2860	membrane
HFD81_18515	COG1253	flavin adenine dinucleotide binding
HFD81_18535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFD81_18570	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFD81_18580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFD81_18615	COG1309	transcriptional regulator
HFD81_18650	COG0758	DNA mediated transformation
HFD81_18660	COG0697	spore germination
HFD81_18665	COG1309	transcriptional regulator
HFD81_18680	COG0386	Belongs to the glutathione peroxidase family
HFD81_18745	COG1121	(ABC) transporter
HFD81_18750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFD81_18755	COG1280	lysine exporter protein (LysE YggA)
HFD81_18760	COG2837	iron assimilation
HFD81_18770	COG0281	malic enzyme
HFD81_18815	COG0519	Catalyzes the synthesis of GMP from XMP
HFD81_18815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFD81_18820	COG4399	Belongs to the UPF0754 family
HFD81_18825	COG2259	Doxx family
HFD81_18830	COG0586	Pfam SNARE associated Golgi protein
HFD81_18845	COG1192	Involved in chromosome partitioning
HFD81_18855	COG0271	Belongs to the BolA IbaG family
HFD81_18875	COG2267	carboxylic ester hydrolase activity
HFD81_18895	COG3321	synthase
HFD81_18895	COG0300	oxidoreductase activity
HFD81_18895	COG4221	oxidoreductase activity
HFD81_18895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFD81_18900	COG1960	acyl-CoA dehydrogenase activity
HFD81_18910	COG2197	response regulator
HFD81_18920	COG3916	Acyl-homoserine-lactone synthase
HFD81_18925	COG0477	Major facilitator Superfamily
HFD81_18930	COG1024	Enoyl-CoA hydratase
HFD81_18935	COG1024	Enoyl-CoA hydratase
HFD81_18940	COG1960	acyl-CoA dehydrogenase activity
HFD81_18945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD81_18965	COG1113	amino acid transport
HFD81_18970	COG1113	amino acid transport
HFD81_18975	COG0251	oxidation-reduction process
HFD81_19015	COG0564	pseudouridine synthase activity
HFD81_19075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFD81_19090	COG1802	Transcriptional regulator
HFD81_19100	COG1448	Aminotransferase
HFD81_19105	COG0277	FAD linked oxidase domain protein
HFD81_19115	COG2186	Transcriptional regulator
HFD81_19125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFD81_19135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFD81_19150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFD81_19155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFD81_19175	COG1215	transferase activity, transferring glycosyl groups
HFD81_19185	COG0438	transferase activity, transferring glycosyl groups
HFD81_19210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFD81_19215	COG1596	polysaccharide export
HFD81_19240	COG0728	peptidoglycan biosynthetic process
HFD81_19245	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFD81_19300	COG0546	phosphoglycolate phosphatase activity
HFD81_19305	COG1028	Short-chain dehydrogenase reductase Sdr
HFD81_19325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD81_19330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD81_19335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD81_19340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD81_19345	COG1116	anion transmembrane transporter activity
HFD81_19350	COG1309	transcriptional regulator
HFD81_19355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFD81_19365	COG0196	riboflavin kinase activity
HFD81_19370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFD81_19380	COG1047	Peptidyl-prolyl cis-trans
HFD81_19420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFD81_19475	COG2951	lytic endotransglycosylase activity
HFD81_19480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFD81_19495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFD81_19505	COG0671	phosphoesterase, PA-phosphatase related
HFD81_19510	COG0861	Integral membrane protein TerC family
HFD81_19520	COG0754	glutathionylspermidine amidase activity
HFD81_19530	COG0402	S-adenosylhomocysteine deaminase activity
HFD81_19545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD81_19550	COG1230	cation diffusion facilitator family transporter
HFD81_19565	COG0706	membrane insertase activity
HFD81_19635	COG1525	nuclease
HFD81_19700	COG1475	DNA binding
HFD81_19715	COG3853	Toxic anion resistance protein (TelA)
HFD81_19850	COG3328	transposase activity
HFD81_19900	COG0741	lytic transglycosylase activity
HFD81_19935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process