locus-tag	class	description
HFD80_00010	COG0592	DNA-directed DNA polymerase activity
HFD80_00020	COG0187	DNA topoisomerase II activity
HFD80_00030	COG0586	Pfam SNARE associated Golgi protein
HFD80_00035	COG0488	(ABC) transporter
HFD80_00060	COG0596	Alpha beta hydrolase
HFD80_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HFD80_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFD80_00110	COG0733	neurotransmitter:sodium symporter activity
HFD80_00150	COG2233	PERMEase
HFD80_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD80_00200	COG2814	Major facilitator Superfamily
HFD80_00205	COG0656	L-ascorbic acid biosynthetic process
HFD80_00210	COG0583	DNA-binding transcription factor activity
HFD80_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD80_00230	COG1064	alcohol dehydrogenase
HFD80_00235	COG2818	Glycosylase
HFD80_00250	COG1194	a g-specific adenine glycosylase
HFD80_00270	COG2983	Belongs to the UPF0260 family
HFD80_00275	COG2133	pyrroloquinoline quinone binding
HFD80_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFD80_00285	COG2116	formate transmembrane transporter activity
HFD80_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD80_00310	COG1335	isochorismatase
HFD80_00315	COG0385	Bile acid
HFD80_00320	COG0534	Mate efflux family protein
HFD80_00325	COG1683	Conserved Protein
HFD80_00345	COG0625	glutathione transferase activity
HFD80_00355	COG1113	amino acid transport
HFD80_00365	COG0523	cobalamin synthesis protein
HFD80_00375	COG2188	Transcriptional regulator
HFD80_00405	COG0010	Belongs to the arginase family
HFD80_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFD80_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HFD80_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFD80_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HFD80_00540	COG0534	Mate efflux family protein
HFD80_00545	COG0436	Aminotransferase
HFD80_00550	COG2733	membrane
HFD80_00565	COG2918	glutathione biosynthetic process
HFD80_00575	COG3501	Rhs element vgr protein
HFD80_00580	COG0791	NLP P60 protein
HFD80_00580	COG1388	LysM domain
HFD80_00595	COG3150	esterase
HFD80_00605	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HFD80_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD80_00630	COG2233	PERMEase
HFD80_00635	COG2351	hydroxyisourate hydrolase activity
HFD80_00670	COG3706	GGDEF domain
HFD80_00685	COG1393	Belongs to the ArsC family
HFD80_00690	COG0708	Exodeoxyribonuclease III
HFD80_00710	COG0189	ligase activity
HFD80_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFD80_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFD80_00755	COG4942	peptidase
HFD80_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFD80_00775	COG2119	membrane
HFD80_00785	COG2433	Pfam Transposase IS66
HFD80_00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD80_00805	COG0426	domain, Protein
HFD80_00830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HFD80_00850	COG1902	pentaerythritol trinitrate reductase activity
HFD80_00855	COG1519	Transferase
HFD80_00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFD80_00865	COG0668	transmembrane transport
HFD80_00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD80_00880	COG1335	isochorismatase
HFD80_00885	COG1522	sequence-specific DNA binding
HFD80_00890	COG3328	transposase activity
HFD80_00915	COG2205	protein histidine kinase activity
HFD80_00915	COG2198	Histidine kinase
HFD80_00915	COG0784	Response regulator, receiver
HFD80_00920	COG3162	membrane
HFD80_00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFD80_00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD80_00945	COG3706	GGDEF domain
HFD80_00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFD80_00960	COG1309	transcriptional regulator
HFD80_00980	COG0352	thiamine-phosphate diphosphorylase activity
HFD80_00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFD80_00980	COG0351	phosphomethylpyrimidine kinase
HFD80_00990	COG2814	Major facilitator Superfamily
HFD80_01005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFD80_01015	COG1113	amino acid transport
HFD80_01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFD80_01030	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_01040	COG1335	isochorismatase
HFD80_01055	COG1061	Type III restriction enzyme res subunit
HFD80_01065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFD80_01070	COG1192	Involved in chromosome partitioning
HFD80_01080	COG1061	Type III restriction enzyme res subunit
HFD80_01120	COG2814	Major facilitator Superfamily
HFD80_01125	COG0583	DNA-binding transcription factor activity
HFD80_01145	COG0667	Aldo Keto reductase
HFD80_01175	COG1733	regulation of RNA biosynthetic process
HFD80_01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD80_01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HFD80_01260	COG2329	Antibiotic biosynthesis monooxygenase
HFD80_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFD80_01320	COG0427	acetyl-CoA hydrolase
HFD80_01335	COG0745	RESPONSE REGULATOR receiver
HFD80_01345	COG0659	secondary active sulfate transmembrane transporter activity
HFD80_01350	COG4221	oxidoreductase activity
HFD80_01355	COG2873	o-acetylhomoserine
HFD80_01360	COG0488	(ABC) transporter
HFD80_01445	COG0833	amino acid
HFD80_01490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HFD80_01495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFD80_01510	COG2226	methyltransferase
HFD80_01560	COG0070	glutamate synthase
HFD80_01560	COG0069	glutamate synthase activity
HFD80_01560	COG0067	glutamate synthase
HFD80_01565	COG0493	'glutamate synthase
HFD80_01575	COG1704	LemA family
HFD80_01580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HFD80_01600	COG3307	-O-antigen
HFD80_01620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFD80_01635	COG0194	GDP metabolic process
HFD80_01685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFD80_01705	COG5380	lipid catabolic process
HFD80_01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFD80_01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFD80_01740	COG0277	FAD linked oxidase domain protein
HFD80_01750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HFD80_01755	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD80_01770	COG1289	transmembrane transporter activity
HFD80_01780	COG0628	permease
HFD80_01785	COG1192	Involved in chromosome partitioning
HFD80_01815	COG0833	amino acid
HFD80_01820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFD80_01825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFD80_01835	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_01875	COG0583	DNA-binding transcription factor activity
HFD80_01920	COG0517	IMP dehydrogenase activity
HFD80_01925	COG1983	PspC domain protein
HFD80_01935	COG1960	acyl-CoA dehydrogenase activity
HFD80_01950	COG0408	coproporphyrinogen oxidase activity
HFD80_01970	COG0513	Belongs to the DEAD box helicase family
HFD80_01980	COG1127	ABC transporter
HFD80_01985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFD80_01995	COG2854	intermembrane phospholipid transfer
HFD80_02005	COG0598	Magnesium transport protein CorA
HFD80_02015	COG0494	nUDIX hydrolase
HFD80_02020	COG1040	competence protein
HFD80_02025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFD80_02045	COG1946	Acyl-CoA thioesterase
HFD80_02050	COG1301	dicarboxylic acid transport
HFD80_02065	COG1959	2 iron, 2 sulfur cluster binding
HFD80_02070	COG1017	nitric oxide dioxygenase activity
HFD80_02070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD80_02075	COG0433	COG0433 Predicted ATPase
HFD80_02080	COG0626	cystathionine gamma-synthase activity
HFD80_02235	COG1960	acyl-CoA dehydrogenase activity
HFD80_02240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HFD80_02270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HFD80_02275	COG0339	signal peptide processing
HFD80_02280	COG0557	exoribonuclease II activity
HFD80_02325	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFD80_02330	COG2169	Transcriptional regulator
HFD80_02335	COG0697	spore germination
HFD80_02340	COG1295	ribonuclease BN
HFD80_02375	COG1702	phosphate starvation-inducible protein PhoH
HFD80_02385	COG0739	heme binding
HFD80_02385	COG0741	lytic transglycosylase activity
HFD80_02385	COG1196	nuclear chromosome segregation
HFD80_02415	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFD80_02420	COG1183	phosphatidylcholine synthase activity
HFD80_02465	COG1960	acyl-CoA dehydrogenase activity
HFD80_02470	COG1309	transcriptional regulator
HFD80_02485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFD80_02490	COG1960	acyl-CoA dehydrogenase activity
HFD80_02510	COG2969	positive regulation of protein catabolic process
HFD80_02520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFD80_02535	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFD80_02540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFD80_02560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFD80_02570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFD80_02575	COG1408	metallophosphoesterase
HFD80_02585	COG2199	diguanylate cyclase activity
HFD80_02645	COG1607	acyl-coa hydrolase
HFD80_02675	COG2350	Protein conserved in bacteria
HFD80_02685	COG0613	PHP domain protein
HFD80_02690	COG3781	membrane
HFD80_02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFD80_02705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFD80_02715	COG1862	Preprotein translocase
HFD80_02760	COG2205	protein histidine kinase activity
HFD80_02765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HFD80_02785	COG0726	polysaccharide deacetylase
HFD80_02790	COG0463	Glycosyl transferase, family 2
HFD80_02795	COG0438	transferase activity, transferring glycosyl groups
HFD80_02860	COG0625	glutathione transferase activity
HFD80_02865	COG0583	DNA-binding transcription factor activity
HFD80_02870	COG1960	acyl-CoA dehydrogenase activity
HFD80_02875	COG1960	acyl-CoA dehydrogenase activity
HFD80_02885	COG2205	protein histidine kinase activity
HFD80_02890	COG0745	RESPONSE REGULATOR receiver
HFD80_02895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFD80_02915	COG2096	Adenosyltransferase
HFD80_02965	COG0285	dihydrofolate synthase activity
HFD80_02985	COG0450	alkyl hydroperoxide reductase
HFD80_03000	COG0477	Major facilitator Superfamily
HFD80_03005	COG1272	protein, Hemolysin III
HFD80_03040	COG0183	Belongs to the thiolase family
HFD80_03045	COG2207	Transcriptional regulator
HFD80_03065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD80_03085	COG0183	Belongs to the thiolase family
HFD80_03095	COG2885	chlorophyll binding
HFD80_03095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HFD80_03105	COG1690	Belongs to the RtcB family
HFD80_03110	COG0833	amino acid
HFD80_03120	COG2233	PERMEase
HFD80_03150	COG2094	Belongs to the DNA glycosylase MPG family
HFD80_03155	COG4772	TonB-dependent receptor
HFD80_03170	COG1902	pentaerythritol trinitrate reductase activity
HFD80_03175	COG0679	Auxin Efflux Carrier
HFD80_03185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD80_03190	COG0354	folic acid binding
HFD80_03200	COG3189	MarR family transcriptional regulator
HFD80_03205	COG2824	Alkylphosphonate utilization operon protein PhnA
HFD80_03210	COG3422	double-strand break repair
HFD80_03250	COG0840	transmembrane signaling receptor activity
HFD80_03270	COG5510	response to toxic substance
HFD80_03280	COG2832	Protein of unknown function (DUF454)
HFD80_03285	COG1376	ErfK ybiS ycfS ynhG family protein
HFD80_03325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFD80_03335	COG1289	transmembrane transporter activity
HFD80_03340	COG2814	Major facilitator Superfamily
HFD80_03360	COG1115	amino acid carrier protein
HFD80_03365	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFD80_03370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFD80_03375	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HFD80_03405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFD80_03415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFD80_03420	COG1077	Cell shape determining protein MreB Mrl
HFD80_03425	COG1792	Involved in formation and maintenance of cell shape
HFD80_03430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HFD80_03435	COG0424	maF-like protein
HFD80_03440	COG1530	ribonuclease E activity
HFD80_03450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD80_03460	COG0560	Phosphoserine phosphatase
HFD80_03470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD80_03495	COG2207	Transcriptional regulator
HFD80_03515	COG1113	amino acid transport
HFD80_03520	COG2828	Protein conserved in bacteria
HFD80_03525	COG0142	geranyltranstransferase activity
HFD80_03530	COG2315	Protein conserved in bacteria
HFD80_03545	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFD80_03565	COG2194	sulfuric ester hydrolase activity
HFD80_03570	COG0745	RESPONSE REGULATOR receiver
HFD80_03575	COG0642	Histidine kinase
HFD80_03585	COG0004	ammonium transporteR
HFD80_03590	COG0583	DNA-binding transcription factor activity
HFD80_03610	COG0525	valine-tRNA ligase activity
HFD80_03620	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_03630	COG0393	Putative heavy-metal-binding
HFD80_03635	COG0393	Putative heavy-metal-binding
HFD80_03640	COG1538	Outer membrane efflux protein
HFD80_03650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD80_03655	COG0671	phosphoesterase, PA-phosphatase related
HFD80_03685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HFD80_03700	COG1648	precorrin-2 dehydrogenase activity
HFD80_03700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFD80_03705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFD80_03710	COG1733	regulation of RNA biosynthetic process
HFD80_03720	COG0531	amino acid
HFD80_03735	COG0321	lipoyl(octanoyl) transferase activity
HFD80_03740	COG2921	Belongs to the UPF0250 family
HFD80_03780	COG2009	succinate dehydrogenase
HFD80_03785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HFD80_03790	COG1053	succinate dehydrogenase
HFD80_03795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFD80_03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD80_03840	COG2354	Protein conserved in bacteria
HFD80_03845	COG2321	neutral zinc metallopeptidase
HFD80_03885	COG2843	Capsule synthesis protein
HFD80_03900	COG0589	response to stress
HFD80_03920	COG0505	Belongs to the CarA family
HFD80_03945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFD80_03950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFD80_04000	COG0477	Major facilitator Superfamily
HFD80_04005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFD80_04020	COG1597	lipid kinase activity
HFD80_04025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFD80_04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD80_04055	COG0584	glycerophosphoryl diester phosphodiesterase
HFD80_04075	COG0741	lytic transglycosylase activity
HFD80_04095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFD80_04110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD80_04135	COG0778	Nitroreductase
HFD80_04150	COG1929	Belongs to the glycerate kinase type-1 family
HFD80_04155	COG0243	molybdopterin cofactor binding
HFD80_04160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFD80_04165	COG3339	Conserved Protein
HFD80_04175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HFD80_04190	COG1113	amino acid transport
HFD80_04200	COG0019	diaminopimelate decarboxylase activity
HFD80_04210	COG1280	lysine exporter protein (LysE YggA)
HFD80_04215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HFD80_04245	COG0463	Glycosyl transferase, family 2
HFD80_04265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD80_04300	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFD80_04305	COG1136	(ABC) transporter
HFD80_04310	COG0658	competence protein
HFD80_04310	COG2333	competence protein COMEC
HFD80_04320	COG0616	signal peptide processing
HFD80_04320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFD80_04325	COG0596	Alpha beta hydrolase
HFD80_04330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFD80_04340	COG0628	permease
HFD80_04375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFD80_04395	COG0823	Involved in the tonB-independent uptake of proteins
HFD80_04415	COG0824	Thioesterase
HFD80_04420	COG1473	amidohydrolase
HFD80_04440	COG0047	phosphoribosylformylglycinamidine synthase activity
HFD80_04440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFD80_04445	COG2814	Major facilitator Superfamily
HFD80_04455	COG1024	Enoyl-CoA hydratase
HFD80_04460	COG1056	cytidyltransferase-related domain
HFD80_04460	COG1051	belongs to the nudix hydrolase family
HFD80_04470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFD80_04485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HFD80_04500	COG4625	pathogenesis
HFD80_04505	COG0583	DNA-binding transcription factor activity
HFD80_04510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFD80_04515	COG4208	sulfate ABC transporter
HFD80_04520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HFD80_04530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFD80_04535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFD80_04540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFD80_04560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFD80_04575	COG0681	Belongs to the peptidase S26 family
HFD80_04590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFD80_04600	COG1381	Involved in DNA repair and RecF pathway recombination
HFD80_04605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFD80_04615	COG4221	oxidoreductase activity
HFD80_04645	COG0436	Aminotransferase
HFD80_04665	COG0556	nucleotide-excision repair
HFD80_04720	COG2070	2-Nitropropane dioxygenase
HFD80_04750	COG1215	transferase activity, transferring glycosyl groups
HFD80_04765	COG0415	Belongs to the DNA photolyase family
HFD80_04775	COG1252	NADH dehydrogenase
HFD80_04780	COG1686	Belongs to the peptidase S11 family
HFD80_04795	COG1187	pseudouridine synthase activity
HFD80_04820	COG0477	Major facilitator Superfamily
HFD80_04825	COG0583	DNA-binding transcription factor activity
HFD80_04840	COG0612	Peptidase, M16
HFD80_04875	COG0352	thiamine-phosphate diphosphorylase activity
HFD80_04910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD80_04925	COG1309	transcriptional regulator
HFD80_04935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFD80_04940	COG0076	glutamate decarboxylase activity
HFD80_04950	COG1522	sequence-specific DNA binding
HFD80_04955	COG3961	Belongs to the TPP enzyme family
HFD80_04960	COG1113	amino acid transport
HFD80_04965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFD80_04970	COG0573	inorganic phosphate transmembrane transporter activity
HFD80_04980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFD80_04985	COG0616	signal peptide processing
HFD80_05020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFD80_05025	COG1686	Belongs to the peptidase S11 family
HFD80_05050	COG0583	DNA-binding transcription factor activity
HFD80_05055	COG1067	ATP-dependent peptidase activity
HFD80_05100	COG1966	Carbon starvation protein
HFD80_05105	COG2879	small protein
HFD80_05140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFD80_05140	COG2508	Transcriptional regulator
HFD80_05160	COG1113	amino acid transport
HFD80_05165	COG0583	DNA-binding transcription factor activity
HFD80_05170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD80_05175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD80_05185	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_05190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD80_05195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HFD80_05195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD80_05230	COG2814	Major facilitator Superfamily
HFD80_05235	COG4948	Mandelate Racemase Muconate Lactonizing
HFD80_05245	COG1309	transcriptional regulator
HFD80_05270	COG1741	Belongs to the pirin family
HFD80_05280	COG2964	Protein conserved in bacteria
HFD80_05295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD80_05300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFD80_05305	COG4605	iron ion homeostasis
HFD80_05310	COG4604	ABC transporter, ATP-binding protein
HFD80_05315	COG4607	ABC-type enterochelin transport system periplasmic component
HFD80_05320	COG4774	siderophore transport
HFD80_05330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD80_05335	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFD80_05340	COG3433	isochorismatase activity
HFD80_05340	COG1535	isochorismatase
HFD80_05355	COG1132	(ABC) transporter
HFD80_05365	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HFD80_05375	COG1169	isochorismate synthase
HFD80_05390	COG3739	integral membrane protein
HFD80_05425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFD80_05455	COG0308	aminopeptidase N
HFD80_05460	COG0512	Glutamine amidotransferase of anthranilate synthase
HFD80_05510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD80_05515	COG4197	protein conserved in bacteria, prophage-related
HFD80_05630	COG5410	chromosome segregation
HFD80_05800	COG0582	viral genome integration into host DNA
HFD80_05810	COG3104	oligopeptide transport
HFD80_05815	COG0174	glutamine synthetase
HFD80_05825	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFD80_05860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFD80_05865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFD80_05870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFD80_05890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFD80_05895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HFD80_05900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HFD80_05915	COG1960	acyl-CoA dehydrogenase activity
HFD80_05920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFD80_05925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD80_05935	COG2223	nitrite transmembrane transporter activity
HFD80_05945	COG0024	Methionine aminopeptidase
HFD80_05950	COG0052	Belongs to the universal ribosomal protein uS2 family
HFD80_05965	COG2207	Transcriptional regulator
HFD80_05990	COG2951	lytic endotransglycosylase activity
HFD80_05995	COG0772	Belongs to the SEDS family
HFD80_06010	COG0842	Transport permease protein
HFD80_06015	COG1131	(ABC) transporter
HFD80_06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD80_06075	COG4215	(ABC) transporter
HFD80_06080	COG4160	amino acid transport
HFD80_06085	COG4598	ABC transporter
HFD80_06095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFD80_06105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD80_06120	COG1720	tRNA m6t6A37 methyltransferase activity
HFD80_06140	COG0745	RESPONSE REGULATOR receiver
HFD80_06145	COG0642	Histidine kinase
HFD80_06155	COG0494	nUDIX hydrolase
HFD80_06165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFD80_06170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFD80_06175	COG3139	Protein of unknown function (DUF1315)
HFD80_06180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFD80_06185	COG1301	dicarboxylic acid transport
HFD80_06190	COG1960	acyl-CoA dehydrogenase activity
HFD80_06195	COG2819	hydrolase of the alpha beta superfamily
HFD80_06205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFD80_06215	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFD80_06220	COG1234	tRNA 3'-trailer cleavage
HFD80_06250	COG2363	Small membrane protein
HFD80_06270	COG0513	Belongs to the DEAD box helicase family
HFD80_06280	COG0778	Nitroreductase
HFD80_06620	COG1286	toxin biosynthetic process
HFD80_06645	COG4783	chaperone-mediated protein folding
HFD80_06650	COG1610	YqeY-like protein
HFD80_06750	COG3111	PFAM Bacterial OB fold (BOF) protein
HFD80_06775	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFD80_06780	COG0786	glutamate:sodium symporter activity
HFD80_06790	COG2186	Transcriptional regulator
HFD80_06840	COG0477	Major facilitator Superfamily
HFD80_06865	COG2985	domain, Protein
HFD80_06875	COG2995	paraquat-inducible protein a
HFD80_06880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFD80_06880	COG3008	intermembrane lipid transfer
HFD80_06890	COG1794	racemase activity, acting on amino acids and derivatives
HFD80_06975	COG0482	sulfurtransferase activity
HFD80_06995	COG3173	Aminoglycoside phosphotransferase
HFD80_07005	COG2433	Pfam Transposase IS66
HFD80_07045	COG1301	dicarboxylic acid transport
HFD80_07055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD80_07060	COG2011	ABC-type metal ion transport system permease component
HFD80_07065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD80_07070	COG1464	Belongs to the NlpA lipoprotein family
HFD80_07075	COG0151	Belongs to the GarS family
HFD80_07080	COG0138	bifunctional purine biosynthesis protein purh
HFD80_07085	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HFD80_07115	COG2308	Evidence 4 Homologs of previously reported genes of
HFD80_07125	COG1305	Transglutaminase-like
HFD80_07135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFD80_07140	COG0305	Participates in initiation and elongation during chromosome replication
HFD80_07165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFD80_07175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFD80_07180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFD80_07205	COG0726	polysaccharide deacetylase
HFD80_07205	COG1649	PFAM Uncharacterised BCR, COG1649
HFD80_07210	COG1215	transferase activity, transferring glycosyl groups
HFD80_07215	COG3658	cytochrome
HFD80_07225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD80_07240	COG0583	DNA-binding transcription factor activity
HFD80_07260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD80_07265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD80_07280	COG1960	acyl-CoA dehydrogenase activity
HFD80_07285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD80_07290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD80_07315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HFD80_07320	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HFD80_07330	COG2205	protein histidine kinase activity
HFD80_07335	COG0745	RESPONSE REGULATOR receiver
HFD80_07340	COG0174	glutamine synthetase
HFD80_07360	COG0729	surface antigen
HFD80_07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFD80_07390	COG2814	Major facilitator Superfamily
HFD80_07405	COG0583	DNA-binding transcription factor activity
HFD80_07420	COG1187	pseudouridine synthase activity
HFD80_07440	COG0802	atpase or kinase
HFD80_07445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFD80_07455	COG1923	regulation of RNA biosynthetic process
HFD80_07460	COG0697	spore germination
HFD80_07475	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD80_07485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFD80_07490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFD80_07490	COG0519	Catalyzes the synthesis of GMP from XMP
HFD80_07495	COG4302	ethanolamine ammonia-lyase activity
HFD80_07500	COG4303	Ethanolamine ammonia lyase large subunit
HFD80_07505	COG0531	amino acid
HFD80_07525	COG1454	alcohol dehydrogenase
HFD80_07530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFD80_07540	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFD80_07560	COG0308	aminopeptidase N
HFD80_07570	COG4221	oxidoreductase activity
HFD80_07580	COG1605	Chorismate mutase
HFD80_07595	COG1309	transcriptional regulator
HFD80_07605	COG0668	transmembrane transport
HFD80_07640	COG4773	Receptor
HFD80_07660	COG0488	(ABC) transporter
HFD80_07665	COG0589	response to stress
HFD80_07690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFD80_07700	COG3135	benzoate transporter
HFD80_07705	COG1522	sequence-specific DNA binding
HFD80_07715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFD80_07720	COG0583	DNA-binding transcription factor activity
HFD80_07730	COG0183	Belongs to the thiolase family
HFD80_07740	COG2030	dehydratase
HFD80_07760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFD80_07770	COG0824	Thioesterase
HFD80_07775	COG1454	alcohol dehydrogenase
HFD80_07785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFD80_07805	COG0069	glutamate synthase activity
HFD80_07825	COG2814	Major facilitator Superfamily
HFD80_07840	COG0511	ligase activity, forming carbon-carbon bonds
HFD80_07860	COG1116	anion transmembrane transporter activity
HFD80_07860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD80_07865	COG0745	RESPONSE REGULATOR receiver
HFD80_07875	COG2146	nitrite reductase [NAD(P)H] activity
HFD80_07875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD80_07880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD80_07885	COG0243	molybdopterin cofactor binding
HFD80_07895	COG0243	molybdopterin cofactor binding
HFD80_07900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFD80_07915	COG0315	cyclic pyranopterin monophosphate synthase activity
HFD80_07915	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFD80_07920	COG0303	'Molybdopterin
HFD80_07930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD80_07935	COG0697	spore germination
HFD80_07955	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HFD80_07960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFD80_08015	COG2204	response regulator
HFD80_08020	COG3852	Histidine kinase
HFD80_08040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFD80_08045	COG0575	Belongs to the CDS family
HFD80_08080	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD80_08095	COG2137	regulation of response to DNA damage stimulus
HFD80_08105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFD80_08110	COG1011	Hydrolase
HFD80_08135	COG1522	sequence-specific DNA binding
HFD80_08145	COG1113	amino acid transport
HFD80_08160	COG0659	secondary active sulfate transmembrane transporter activity
HFD80_08165	COG2135	peptidase activity
HFD80_08180	COG5001	Diguanylate cyclase
HFD80_08180	COG3300	MHYT domain
HFD80_08200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFD80_08200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFD80_08200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFD80_08205	COG1105	Belongs to the carbohydrate kinase PfkB family
HFD80_08210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFD80_08210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFD80_08240	COG0024	Methionine aminopeptidase
HFD80_08245	COG0583	DNA-binding transcription factor activity
HFD80_08255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFD80_08260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFD80_08265	COG0517	IMP dehydrogenase activity
HFD80_08265	COG0516	GMP reductase activity
HFD80_08290	COG0552	protein localization to endoplasmic reticulum
HFD80_08300	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HFD80_08315	COG4890	Cyd operon protein YbgT
HFD80_08320	COG1294	oxidase, subunit
HFD80_08335	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFD80_08345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFD80_08350	COG4774	siderophore transport
HFD80_08365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFD80_08370	COG0569	domain protein
HFD80_08375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFD80_08405	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HFD80_08410	COG0542	response to heat
HFD80_08435	COG1902	pentaerythritol trinitrate reductase activity
HFD80_08435	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD80_08480	COG2323	membrane
HFD80_08485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HFD80_08495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD80_08500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD80_08505	COG0183	Belongs to the thiolase family
HFD80_08510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFD80_08515	COG0596	Alpha beta hydrolase
HFD80_08520	COG2271	Major facilitator Superfamily
HFD80_08525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFD80_08530	COG3485	protocatechuate 3,4-dioxygenase
HFD80_08535	COG3485	protocatechuate 3,4-dioxygenase
HFD80_08540	COG0710	3-dehydroquinate dehydratase activity
HFD80_08545	COG3420	alginic acid biosynthetic process
HFD80_08550	COG3659	wide pore channel activity
HFD80_08555	COG4993	Dehydrogenase
HFD80_08565	COG2391	methyltransferase activity
HFD80_08580	COG1414	Transcriptional regulator
HFD80_08585	COG0583	DNA-binding transcription factor activity
HFD80_08590	COG1960	acyl-CoA dehydrogenase activity
HFD80_08615	COG2814	Major facilitator Superfamily
HFD80_08625	COG0154	amidase activity
HFD80_08645	COG4638	Rieske (2fe-2S)
HFD80_08655	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_08665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD80_08675	COG3733	amine oxidase
HFD80_08685	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_08695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD80_08700	COG0183	Belongs to the thiolase family
HFD80_08705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD80_08710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD80_08720	COG4829	muconolactone delta-isomerase
HFD80_08725	COG4948	Mandelate Racemase Muconate Lactonizing
HFD80_08730	COG0583	DNA-binding transcription factor activity
HFD80_08740	COG2186	Transcriptional regulator
HFD80_08760	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_08780	COG1960	acyl-CoA dehydrogenase activity
HFD80_08785	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_08790	COG3829	transcription factor binding
HFD80_08800	COG3162	membrane
HFD80_08815	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_08830	COG0753	catalase activity
HFD80_08850	COG1846	Transcriptional regulator
HFD80_08855	COG1902	pentaerythritol trinitrate reductase activity
HFD80_08855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD80_08865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFD80_08895	COG1309	transcriptional regulator
HFD80_08905	COG1335	isochorismatase
HFD80_08910	COG0583	DNA-binding transcription factor activity
HFD80_08920	COG0475	glutathione-regulated potassium exporter activity
HFD80_08920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD80_08930	COG1473	amidohydrolase
HFD80_08940	COG2831	hemolysin activation secretion protein
HFD80_08945	COG3210	domain, Protein
HFD80_08975	COG2188	Transcriptional regulator
HFD80_08990	COG0583	DNA-binding transcription factor activity
HFD80_09020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFD80_09040	COG1566	PFAM secretion protein HlyD family protein
HFD80_09055	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_09060	COG0129	dihydroxy-acid dehydratase activity
HFD80_09070	COG0583	DNA-binding transcription factor activity
HFD80_09075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFD80_09085	COG2084	Dehydrogenase
HFD80_09090	COG2207	Transcriptional regulator
HFD80_09105	COG1064	alcohol dehydrogenase
HFD80_09120	COG1120	ATPase activity
HFD80_09140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFD80_09255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HFD80_09305	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_09320	COG2207	Transcriptional regulator
HFD80_09330	COG2205	protein histidine kinase activity
HFD80_09335	COG0745	RESPONSE REGULATOR receiver
HFD80_09340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD80_09345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFD80_09350	COG1538	Outer membrane efflux protein
HFD80_09360	COG2072	flavoprotein involved in K transport
HFD80_09380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD80_09400	COG3539	Fimbrial protein
HFD80_09430	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HFD80_09440	COG0753	catalase activity
HFD80_09455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFD80_09520	COG1535	isochorismatase
HFD80_09520	COG3433	isochorismatase activity
HFD80_09525	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_09530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFD80_09535	COG4149	molybdate abc transporter
HFD80_09540	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFD80_09550	COG4638	Rieske (2fe-2S)
HFD80_09555	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFD80_09560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD80_09560	COG0543	2 iron, 2 sulfur cluster binding
HFD80_09585	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_09600	COG2207	Transcriptional regulator
HFD80_09610	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_09615	COG2610	gluconate transmembrane transporter activity
HFD80_09625	COG0583	DNA-binding transcription factor activity
HFD80_09635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD80_09640	COG2031	fatty acid transporter
HFD80_09645	COG0183	Belongs to the thiolase family
HFD80_09650	COG0583	DNA-binding transcription factor activity
HFD80_09655	COG0583	DNA-binding transcription factor activity
HFD80_09670	COG1027	Aspartate ammonia-lyase
HFD80_09680	COG0477	Major facilitator Superfamily
HFD80_09700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD80_09705	COG4521	taurine ABC transporter
HFD80_09720	COG2188	Transcriptional regulator
HFD80_09730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFD80_09735	COG1733	regulation of RNA biosynthetic process
HFD80_09740	COG2207	Transcriptional regulator
HFD80_09740	COG3708	Transcriptional regulator
HFD80_09755	COG0730	response to heat
HFD80_09765	COG3453	Protein conserved in bacteria
HFD80_09765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD80_09775	COG3781	membrane
HFD80_09780	COG1063	alcohol dehydrogenase
HFD80_09790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD80_09795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFD80_09800	COG0022	dehydrogenase e1 component
HFD80_09805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFD80_09810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFD80_09825	COG3706	GGDEF domain
HFD80_09840	COG0133	tryptophan synthase activity
HFD80_09850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFD80_09885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFD80_09970	COG0842	Transport permease protein
HFD80_09975	COG0842	Transport permease protein
HFD80_09980	COG1131	(ABC) transporter
HFD80_09995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD80_10030	COG0730	response to heat
HFD80_10035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFD80_10055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFD80_10110	COG4264	IucA IucC family
HFD80_10115	COG4264	IucA IucC family
HFD80_10135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFD80_10150	COG1960	acyl-CoA dehydrogenase activity
HFD80_10155	COG1960	acyl-CoA dehydrogenase activity
HFD80_10160	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFD80_10165	COG2207	Transcriptional regulator
HFD80_10170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFD80_10175	COG0776	regulation of translation
HFD80_10200	COG0822	iron-sulfur transferase activity
HFD80_10205	COG0316	Belongs to the HesB IscA family
HFD80_10235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFD80_10255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFD80_10260	COG0702	epimerase
HFD80_10295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFD80_10305	COG0339	signal peptide processing
HFD80_10355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFD80_10360	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFD80_10390	COG0776	regulation of translation
HFD80_10455	COG0084	hydrolase, TatD family'
HFD80_10475	COG1663	tetraacyldisaccharide 4'-kinase activity
HFD80_10480	COG1132	(ABC) transporter
HFD80_10490	COG0811	peptide transport
HFD80_10495	COG1475	DNA binding
HFD80_10500	COG1192	Involved in chromosome partitioning
HFD80_10510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFD80_10525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFD80_10530	COG0191	fructose-bisphosphate aldolase activity
HFD80_10550	COG0424	maF-like protein
HFD80_10555	COG2850	peptidyl-arginine hydroxylation
HFD80_10565	COG0640	Transcriptional regulator
HFD80_10575	COG3619	membrane
HFD80_10580	COG3122	Protein conserved in bacteria
HFD80_10585	COG1132	(ABC) transporter
HFD80_10605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HFD80_10610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFD80_10620	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFD80_10620	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFD80_10620	COG0506	proline dehydrogenase activity
HFD80_10625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HFD80_10640	COG3698	Phosphodiester glycosidase
HFD80_10650	COG2353	YceI-like domain
HFD80_10660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFD80_10705	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFD80_10705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HFD80_10730	COG3539	Fimbrial protein
HFD80_10735	COG3121	Chaperone
HFD80_10760	COG0697	spore germination
HFD80_10770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFD80_10780	COG0583	DNA-binding transcription factor activity
HFD80_10800	COG1309	transcriptional regulator
HFD80_10815	COG1522	sequence-specific DNA binding
HFD80_10825	COG1126	abc transporter atp-binding protein
HFD80_10830	COG0765	amino acid transport
HFD80_10835	COG0765	amino acid transport
HFD80_10865	COG1464	Belongs to the NlpA lipoprotein family
HFD80_10875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD80_10880	COG2011	ABC-type metal ion transport system permease component
HFD80_10885	COG0012	GTP binding
HFD80_10910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFD80_10950	COG0386	Belongs to the glutathione peroxidase family
HFD80_10960	COG0436	Aminotransferase
HFD80_11000	COG3634	alkyl hydroperoxide reductase activity
HFD80_11015	COG0583	DNA-binding transcription factor activity
HFD80_11020	COG0798	PFAM Bile acid sodium symporter
HFD80_11025	COG0640	Transcriptional regulator
HFD80_11040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFD80_11050	COG0583	DNA-binding transcription factor activity
HFD80_11060	COG1953	Uracil, thiamine, allantoin
HFD80_11070	COG2175	clavaminate synthase activity
HFD80_11075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD80_11080	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HFD80_11085	COG4521	taurine ABC transporter
HFD80_11095	COG0477	Major facilitator Superfamily
HFD80_11115	COG1271	oxidase subunit
HFD80_11120	COG1294	oxidase, subunit
HFD80_11130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD80_11150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HFD80_11170	COG3052	prosthetic group binding
HFD80_11175	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HFD80_11185	COG2814	Major facilitator Superfamily
HFD80_11205	COG1346	cytolysis
HFD80_11215	COG0583	DNA-binding transcription factor activity
HFD80_11220	COG0625	glutathione transferase activity
HFD80_11225	COG0625	glutathione transferase activity
HFD80_11230	COG0583	DNA-binding transcription factor activity
HFD80_11245	COG1045	serine acetyltransferase
HFD80_11250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFD80_11255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFD80_11265	COG1280	lysine exporter protein (LysE YggA)
HFD80_11280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD80_11285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD80_11290	COG1126	abc transporter atp-binding protein
HFD80_11295	COG0765	amino acid transport
HFD80_11300	COG0765	amino acid transport
HFD80_11320	COG0784	Response regulator, receiver
HFD80_11320	COG2205	protein histidine kinase activity
HFD80_11340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD80_11360	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_11410	COG0583	DNA-binding transcription factor activity
HFD80_11430	COG0318	PFAM AMP-dependent synthetase and ligase
HFD80_11435	COG1309	transcriptional regulator
HFD80_11440	COG1960	acyl-CoA dehydrogenase activity
HFD80_11445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFD80_11450	COG1024	Enoyl-CoA hydratase
HFD80_11455	COG4770	biotin carboxylase activity
HFD80_11465	COG0583	DNA-binding transcription factor activity
HFD80_11480	COG1960	acyl-CoA dehydrogenase activity
HFD80_11490	COG2814	Major facilitator Superfamily
HFD80_11500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD80_11505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD80_11510	COG2814	Major facilitator Superfamily
HFD80_11515	COG1960	acyl-CoA dehydrogenase activity
HFD80_11520	COG1024	Enoyl-CoA hydratase
HFD80_11525	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_11530	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD80_11535	COG0183	Belongs to the thiolase family
HFD80_11545	COG2814	Major facilitator Superfamily
HFD80_11555	COG1024	Enoyl-CoA hydratase
HFD80_11570	COG1960	acyl-CoA dehydrogenase activity
HFD80_11575	COG2814	Major facilitator Superfamily
HFD80_11580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFD80_11585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HFD80_11600	COG3842	ATPase activity
HFD80_11605	COG1840	ABC-type Fe3 transport system, periplasmic component
HFD80_11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD80_11620	COG1414	Transcriptional regulator
HFD80_11630	COG0583	DNA-binding transcription factor activity
HFD80_11635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFD80_11640	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_11650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFD80_11660	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_11665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD80_11670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD80_11675	COG2267	carboxylic ester hydrolase activity
HFD80_11695	COG3038	cytochrome b561
HFD80_11700	COG0753	catalase activity
HFD80_11735	COG2050	protein possibly involved in aromatic compounds catabolism
HFD80_11745	COG3327	negative regulation of DNA-templated transcription, initiation
HFD80_11750	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFD80_11755	COG0183	Belongs to the thiolase family
HFD80_11760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD80_11765	COG1024	Enoyl-CoA hydratase
HFD80_11770	COG1024	Enoyl-CoA hydratase
HFD80_11775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD80_11780	COG2151	metal-sulfur cluster biosynthetic enzyme
HFD80_11785	COG3396	Phenylacetate-CoA oxygenase
HFD80_11790	COG3460	Phenylacetate-CoA oxygenase
HFD80_11795	COG3396	Phenylacetate-CoA oxygenase
HFD80_11800	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_11800	COG2030	dehydratase
HFD80_11805	COG1760	l-serine dehydratase
HFD80_11810	COG0531	amino acid
HFD80_11815	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_11830	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD80_11840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD80_11860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD80_11870	COG0789	Transcriptional regulator
HFD80_11885	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HFD80_11900	COG2807	transmembrane transport
HFD80_11905	COG0590	tRNA wobble adenosine to inosine editing
HFD80_12020	COG1116	anion transmembrane transporter activity
HFD80_12025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD80_12035	COG0864	Transcriptional regulator
HFD80_12055	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD80_12060	COG0439	Biotin carboxylase
HFD80_12075	COG1063	alcohol dehydrogenase
HFD80_12085	COG1309	transcriptional regulator
HFD80_12105	COG0038	chloride channel
HFD80_12110	COG4770	biotin carboxylase activity
HFD80_12130	COG1914	H( )-stimulated, divalent metal cation uptake system
HFD80_12135	COG0583	DNA-binding transcription factor activity
HFD80_12150	COG3209	COG3209 Rhs family protein
HFD80_12155	COG3501	Rhs element vgr protein
HFD80_12185	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD80_12205	COG2814	Major facilitator Superfamily
HFD80_12215	COG1560	Kdo2-lipid A biosynthetic process
HFD80_12225	COG5006	permease, DMT superfamily
HFD80_12230	COG1522	sequence-specific DNA binding
HFD80_12245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFD80_12255	COG4122	O-methyltransferase activity
HFD80_12285	COG1538	Outer membrane efflux protein
HFD80_12295	COG1137	ATPase activity
HFD80_12300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFD80_12310	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HFD80_12315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFD80_12315	COG0517	IMP dehydrogenase activity
HFD80_12355	COG2814	Major facilitator Superfamily
HFD80_12390	COG1278	Cold shock
HFD80_12395	COG1280	lysine exporter protein (LysE YggA)
HFD80_12430	COG1570	exodeoxyribonuclease VII activity
HFD80_12480	COG0583	DNA-binding transcription factor activity
HFD80_12485	COG4638	Rieske (2fe-2S)
HFD80_12490	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFD80_12495	COG0543	2 iron, 2 sulfur cluster binding
HFD80_12495	COG0633	Ferredoxin
HFD80_12500	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_12505	COG3135	benzoate transporter
HFD80_12510	COG2814	Major facilitator Superfamily
HFD80_12525	COG1643	Atp-dependent helicase
HFD80_12530	COG0450	alkyl hydroperoxide reductase
HFD80_12540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HFD80_12550	COG3634	alkyl hydroperoxide reductase activity
HFD80_12570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFD80_12575	COG0625	glutathione transferase activity
HFD80_12585	COG2885	chlorophyll binding
HFD80_12620	COG0542	response to heat
HFD80_12635	COG1765	OsmC-like protein
HFD80_12650	COG0667	Aldo Keto reductase
HFD80_12665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HFD80_12675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFD80_12685	COG0527	aspartate kinase activity
HFD80_12695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFD80_12705	COG3038	cytochrome b561
HFD80_12710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFD80_12715	COG2252	PERMEase
HFD80_12725	COG2072	flavoprotein involved in K transport
HFD80_12740	COG1741	Belongs to the pirin family
HFD80_12745	COG1309	transcriptional regulator
HFD80_12755	COG0300	oxidoreductase activity
HFD80_12860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFD80_12890	COG1113	amino acid transport
HFD80_12910	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_12930	COG0531	amino acid
HFD80_12940	COG1113	amino acid transport
HFD80_12980	COG3209	COG3209 Rhs family protein
HFD80_12985	COG3501	Rhs element vgr protein
HFD80_13010	COG4269	membrane
HFD80_13025	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD80_13025	COG1902	pentaerythritol trinitrate reductase activity
HFD80_13035	COG2203	Gaf domain
HFD80_13035	COG3706	GGDEF domain
HFD80_13035	COG4251	negative regulation of phosphorylation
HFD80_13035	COG5001	Diguanylate cyclase
HFD80_13045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD80_13065	COG4172	Belongs to the ABC transporter superfamily
HFD80_13070	COG4239	(ABC) transporter, permease
HFD80_13075	COG4174	ABC transporter (Permease)
HFD80_13085	COG1388	LysM domain
HFD80_13085	COG0741	lytic transglycosylase activity
HFD80_13085	COG1388	LysM domain
HFD80_13085	COG0741	lytic transglycosylase activity
HFD80_13090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD80_13130	COG0583	DNA-binding transcription factor activity
HFD80_13135	COG1279	arginine transmembrane transporter activity
HFD80_13155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD80_13160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD80_13165	COG0006	proline dipeptidase activity
HFD80_13250	COG1196	nuclear chromosome segregation
HFD80_13250	COG0739	heme binding
HFD80_13250	COG0741	lytic transglycosylase activity
HFD80_13310	COG4695	Portal protein
HFD80_13405	COG0305	Participates in initiation and elongation during chromosome replication
HFD80_13420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD80_13470	COG2194	sulfuric ester hydrolase activity
HFD80_13515	COG0739	heme binding
HFD80_13840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFD80_13865	COG3384	dioxygenase
HFD80_13875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFD80_13880	COG2878	Part of a membrane complex involved in electron transport
HFD80_13885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFD80_13910	COG0768	penicillin binding
HFD80_13915	COG0742	ribosomal rna small subunit methyltransferase
HFD80_13930	COG0830	nickel cation binding
HFD80_13940	COG0804	urea catabolic process
HFD80_13980	COG1253	flavin adenine dinucleotide binding
HFD80_13985	COG2851	Citrate transporter
HFD80_14035	COG1773	rubredoxin
HFD80_14040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD80_14050	COG0583	DNA-binding transcription factor activity
HFD80_14075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HFD80_14080	COG4181	ATPase activity
HFD80_14125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HFD80_14145	COG0306	phosphate transporter
HFD80_14155	COG3958	Transketolase
HFD80_14160	COG3959	Transketolase, thiamine diphosphate binding domain
HFD80_14165	COG2271	Major facilitator Superfamily
HFD80_14170	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_14175	COG0583	DNA-binding transcription factor activity
HFD80_14190	COG2223	nitrite transmembrane transporter activity
HFD80_14195	COG2207	Transcriptional regulator
HFD80_14200	COG2066	Belongs to the glutaminase family
HFD80_14205	COG0242	peptide deformylase activity
HFD80_14210	COG0477	Major facilitator Superfamily
HFD80_14220	COG0028	Belongs to the TPP enzyme family
HFD80_14235	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_14240	COG2267	carboxylic ester hydrolase activity
HFD80_14250	COG2271	Major facilitator Superfamily
HFD80_14255	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD80_14265	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_14285	COG1414	Transcriptional regulator
HFD80_14300	COG1024	Enoyl-CoA hydratase
HFD80_14310	COG1215	transferase activity, transferring glycosyl groups
HFD80_14315	COG0726	polysaccharide deacetylase
HFD80_14315	COG1649	PFAM Uncharacterised BCR, COG1649
HFD80_14325	COG4681	YaeQ
HFD80_14335	COG0523	cobalamin synthesis protein
HFD80_14345	COG1607	acyl-coa hydrolase
HFD80_14355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD80_14360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD80_14365	COG1309	transcriptional regulator
HFD80_14390	COG2040	homocysteine
HFD80_14395	COG0531	amino acid
HFD80_14420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD80_14425	COG0477	Major facilitator Superfamily
HFD80_14475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFD80_14560	COG0592	DNA-directed DNA polymerase activity
HFD80_14600	COG2026	Addiction module toxin, RelE StbE family
HFD80_14795	COG1484	DNA-dependent DNA replication
HFD80_14935	COG0405	Gamma-glutamyltransferase
HFD80_14940	COG2814	Major facilitator Superfamily
HFD80_14950	COG2050	protein possibly involved in aromatic compounds catabolism
HFD80_14965	COG1090	epimerase
HFD80_14985	COG0420	3'-5' exonuclease activity
HFD80_15010	COG0735	belongs to the Fur family
HFD80_15015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFD80_15035	COG0121	glutamine amidotransferase
HFD80_15050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFD80_15060	COG0210	DNA helicase
HFD80_15065	COG2885	chlorophyll binding
HFD80_15070	COG0204	Acyl-transferase
HFD80_15085	COG2894	cell division
HFD80_15110	COG1280	lysine exporter protein (LysE YggA)
HFD80_15115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFD80_15115	COG1674	ftsk spoiiie
HFD80_15120	COG0492	ferredoxin-NADP+ reductase activity
HFD80_15125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HFD80_15135	COG0456	acetyltransferase
HFD80_15195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HFD80_15195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFD80_15215	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_15235	COG0473	3-isopropylmalate dehydrogenase activity
HFD80_15240	COG0583	DNA-binding transcription factor activity
HFD80_15260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFD80_15285	COG0564	pseudouridine synthase activity
HFD80_15295	COG0358	DNA primase activity
HFD80_15310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HFD80_15340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFD80_15370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFD80_15380	COG0351	phosphomethylpyrimidine kinase
HFD80_15380	COG0352	thiamine-phosphate diphosphorylase activity
HFD80_15380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFD80_15390	COG1652	LysM domain
HFD80_15415	COG1399	metal-binding, possibly nucleic acid-binding protein
HFD80_15420	COG3101	peptidyl-lysine hydroxylation
HFD80_15425	COG0009	L-threonylcarbamoyladenylate synthase
HFD80_15430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HFD80_15435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFD80_15450	COG4106	trans-aconitate 2-methyltransferase activity
HFD80_15465	COG0596	Alpha beta hydrolase
HFD80_15465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD80_15465	COG2226	methyltransferase
HFD80_15470	COG1877	trehalose-phosphatase activity
HFD80_15475	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HFD80_15480	COG2223	nitrite transmembrane transporter activity
HFD80_15500	COG1196	nuclear chromosome segregation
HFD80_15510	COG0730	response to heat
HFD80_15525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFD80_15535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFD80_15585	COG0489	protein tyrosine kinase activity
HFD80_15595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD80_15595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD80_15625	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HFD80_15630	COG2081	HI0933 family
HFD80_15640	COG0668	transmembrane transport
HFD80_15660	COG0583	DNA-binding transcription factor activity
HFD80_15680	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFD80_15685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFD80_15715	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HFD80_15750	COG2205	protein histidine kinase activity
HFD80_15755	COG0745	RESPONSE REGULATOR receiver
HFD80_15775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFD80_15785	COG2205	protein histidine kinase activity
HFD80_15855	COG4993	Dehydrogenase
HFD80_15875	COG0384	phenazine biosynthesis protein PhzF
HFD80_15895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD80_15910	COG0583	DNA-binding transcription factor activity
HFD80_15930	COG1473	amidohydrolase
HFD80_15940	COG0583	DNA-binding transcription factor activity
HFD80_15955	COG0583	DNA-binding transcription factor activity
HFD80_15960	COG1053	succinate dehydrogenase
HFD80_15970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFD80_15975	COG2814	Major facilitator Superfamily
HFD80_15980	COG1960	acyl-CoA dehydrogenase activity
HFD80_15985	COG0583	DNA-binding transcription factor activity
HFD80_15990	COG1063	alcohol dehydrogenase
HFD80_16020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFD80_16025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFD80_16030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFD80_16045	COG3667	copper resistance
HFD80_16050	COG2132	Multicopper oxidase
HFD80_16060	COG0561	phosphatase activity
HFD80_16065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFD80_16090	COG1214	PFAM Peptidase M22, glycoprotease
HFD80_16140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFD80_16150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFD80_16155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFD80_16160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFD80_16220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFD80_16230	COG1846	Transcriptional regulator
HFD80_16235	COG1764	response to oxidative stress
HFD80_16275	COG0037	tRNA processing
HFD80_16285	COG0248	Ppx GppA phosphatase
HFD80_16315	COG0072	phenylalanine-tRNA ligase activity
HFD80_16355	COG1238	metal cluster binding
HFD80_16360	COG0625	glutathione transferase activity
HFD80_16375	COG0318	PFAM AMP-dependent synthetase and ligase
HFD80_16380	COG3028	Belongs to the UPF0307 family
HFD80_16385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFD80_16405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFD80_16410	COG0617	tRNA 3'-terminal CCA addition
HFD80_16415	COG1555	photosystem II stabilization
HFD80_16420	COG3956	TIGRFAM MazG family protein
HFD80_16430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFD80_16450	COG0784	Response regulator, receiver
HFD80_16450	COG5002	protein histidine kinase activity
HFD80_16450	COG2205	protein histidine kinase activity
HFD80_16455	COG1024	Enoyl-CoA hydratase
HFD80_16460	COG2084	Dehydrogenase
HFD80_16465	COG3622	Belongs to the hyi family
HFD80_16495	COG0697	spore germination
HFD80_16505	COG2814	Major facilitator Superfamily
HFD80_16510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFD80_16520	COG0583	DNA-binding transcription factor activity
HFD80_16530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFD80_16545	COG0084	hydrolase, TatD family'
HFD80_16560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFD80_16590	COG0440	acetolactate synthase activity
HFD80_16595	COG0028	Belongs to the TPP enzyme family
HFD80_16620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD80_16625	COG0577	efflux transmembrane transporter activity
HFD80_16625	COG1136	(ABC) transporter
HFD80_16630	COG1538	Outer membrane efflux protein
HFD80_16645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HFD80_16650	COG1162	GTPase activity
HFD80_16660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFD80_16680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFD80_16685	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_16725	COG2986	histidine ammonia-lyase
HFD80_16740	COG0318	PFAM AMP-dependent synthetase and ligase
HFD80_16750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFD80_16795	COG1426	Protein conserved in bacteria
HFD80_16830	COG0793	Belongs to the peptidase S41A family
HFD80_16845	COG2267	carboxylic ester hydrolase activity
HFD80_16855	COG1012	belongs to the aldehyde dehydrogenase family
HFD80_16860	COG3265	gluconokinase activity
HFD80_16870	COG0800	Aldolase
HFD80_16880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFD80_16885	COG0857	belongs to the CobB CobQ family
HFD80_16885	COG0280	phosphate acetyltransferase
HFD80_16890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFD80_16890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFD80_16910	COG0740	serine-type endopeptidase activity
HFD80_16920	COG4774	siderophore transport
HFD80_16930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFD80_16940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD80_16940	COG2813	Specifically methylates the guanine in position
HFD80_17040	COG0788	formyltetrahydrofolate deformylase activity
HFD80_17065	COG4651	solute:proton antiporter activity
HFD80_17065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD80_17085	COG0724	RNA recognition motif
HFD80_17090	COG0210	DNA helicase
HFD80_17115	COG1733	regulation of RNA biosynthetic process
HFD80_17125	COG2900	Belongs to the SlyX family
HFD80_17135	COG1280	lysine exporter protein (LysE YggA)
HFD80_17140	COG1560	Kdo2-lipid A biosynthetic process
HFD80_17150	COG1301	dicarboxylic acid transport
HFD80_17205	COG0473	3-isopropylmalate dehydrogenase activity
HFD80_17270	COG0583	DNA-binding transcription factor activity
HFD80_17280	COG0625	glutathione transferase activity
HFD80_17285	COG2378	regulation of single-species biofilm formation
HFD80_17290	COG0546	phosphoglycolate phosphatase activity
HFD80_17305	COG1530	ribonuclease E activity
HFD80_17310	COG0318	PFAM AMP-dependent synthetase and ligase
HFD80_17325	COG0583	DNA-binding transcription factor activity
HFD80_17330	COG4221	oxidoreductase activity
HFD80_17335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFD80_17345	COG0534	Mate efflux family protein
HFD80_17360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HFD80_17400	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HFD80_17405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD80_17420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFD80_17430	COG0644	oxidoreductase
HFD80_17430	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HFD80_17435	COG0425	Belongs to the sulfur carrier protein TusA family
HFD80_17440	COG4535	Mg2 and Co2 transporter CorC
HFD80_17450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD80_17470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFD80_17475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD80_17475	COG0475	glutathione-regulated potassium exporter activity
HFD80_17480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFD80_17490	COG0484	heat shock protein binding
HFD80_17495	COG0789	Transcriptional regulator
HFD80_17500	COG0598	Magnesium transport protein CorA
HFD80_17520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFD80_17525	COG1074	ATP-dependent DNA helicase activity
HFD80_17530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HFD80_17550	COG2226	methyltransferase
HFD80_17565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD80_17570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFD80_17585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFD80_17585	COG2111	Na H antiporter
HFD80_17590	COG1006	Multisubunit Na H antiporter MnhC subunit
HFD80_17595	COG0651	ATP synthesis coupled electron transport
HFD80_17605	COG2212	antiporter activity
HFD80_17625	COG0195	Participates in both transcription termination and antitermination
HFD80_17675	COG0237	dephospho-CoA kinase activity
HFD80_17685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFD80_17700	COG0497	DNA recombination
HFD80_17710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFD80_17740	COG2169	Transcriptional regulator
HFD80_17740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFD80_17745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFD80_17810	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFD80_17825	COG0326	Molecular chaperone. Has ATPase activity
HFD80_17840	COG2056	Na+-H+ antiporter family
HFD80_17845	COG0596	Alpha beta hydrolase
HFD80_17940	COG0546	phosphoglycolate phosphatase activity
HFD80_17945	COG1716	ATPase activity
HFD80_17990	COG0181	hydroxymethylbilane synthase activity
HFD80_18000	COG3275	phosphorelay sensor kinase activity
HFD80_18020	COG1538	Outer membrane efflux protein
HFD80_18025	COG0697	spore germination
HFD80_18050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFD80_18055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFD80_18060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFD80_18065	COG0772	Belongs to the SEDS family
HFD80_18090	COG4974	Belongs to the 'phage' integrase family
HFD80_18095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD80_18105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFD80_18115	COG2197	response regulator
HFD80_18130	COG0793	Belongs to the peptidase S41A family
HFD80_18135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFD80_18140	COG0795	lipopolysaccharide-transporting ATPase activity
HFD80_18180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFD80_18180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFD80_18190	COG0004	ammonium transporteR
HFD80_18195	COG0347	Belongs to the P(II) protein family
HFD80_18205	COG0606	chelatase, subunit chli
HFD80_18275	COG0659	secondary active sulfate transmembrane transporter activity
HFD80_18280	COG0589	response to stress
HFD80_18320	COG0606	chelatase, subunit chli
HFD80_18325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD80_18335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD80_18350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HFD80_18365	COG0318	PFAM AMP-dependent synthetase and ligase
HFD80_18375	COG0477	Major facilitator Superfamily
HFD80_18380	COG2860	membrane
HFD80_18390	COG1253	flavin adenine dinucleotide binding
HFD80_18410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFD80_18445	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFD80_18455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFD80_18490	COG1309	transcriptional regulator
HFD80_18525	COG0758	DNA mediated transformation
HFD80_18535	COG0697	spore germination
HFD80_18540	COG1309	transcriptional regulator
HFD80_18555	COG0386	Belongs to the glutathione peroxidase family
HFD80_18620	COG1121	(ABC) transporter
HFD80_18625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFD80_18630	COG1280	lysine exporter protein (LysE YggA)
HFD80_18635	COG2837	iron assimilation
HFD80_18645	COG0281	malic enzyme
HFD80_18690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFD80_18690	COG0519	Catalyzes the synthesis of GMP from XMP
HFD80_18695	COG4399	Belongs to the UPF0754 family
HFD80_18700	COG2259	Doxx family
HFD80_18705	COG0586	Pfam SNARE associated Golgi protein
HFD80_18720	COG1192	Involved in chromosome partitioning
HFD80_18730	COG0271	Belongs to the BolA IbaG family
HFD80_18750	COG2267	carboxylic ester hydrolase activity
HFD80_18770	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HFD80_18770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFD80_18770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFD80_18770	COG3321	synthase
HFD80_18775	COG1960	acyl-CoA dehydrogenase activity
HFD80_18785	COG2197	response regulator
HFD80_18795	COG3916	Acyl-homoserine-lactone synthase
HFD80_18800	COG0477	Major facilitator Superfamily
HFD80_18805	COG1024	Enoyl-CoA hydratase
HFD80_18810	COG1024	Enoyl-CoA hydratase
HFD80_18815	COG1960	acyl-CoA dehydrogenase activity
HFD80_18820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD80_18840	COG1113	amino acid transport
HFD80_18845	COG1113	amino acid transport
HFD80_18850	COG0251	oxidation-reduction process
HFD80_18890	COG0564	pseudouridine synthase activity
HFD80_18950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFD80_18965	COG1802	Transcriptional regulator
HFD80_18975	COG1448	Aminotransferase
HFD80_18980	COG0277	FAD linked oxidase domain protein
HFD80_18990	COG2186	Transcriptional regulator
HFD80_19000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFD80_19010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFD80_19025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFD80_19030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFD80_19050	COG1215	transferase activity, transferring glycosyl groups
HFD80_19060	COG0438	transferase activity, transferring glycosyl groups
HFD80_19085	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFD80_19090	COG1596	polysaccharide export
HFD80_19115	COG0728	peptidoglycan biosynthetic process
HFD80_19120	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFD80_19175	COG0546	phosphoglycolate phosphatase activity
HFD80_19180	COG1028	Short-chain dehydrogenase reductase Sdr
HFD80_19200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD80_19205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD80_19210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD80_19215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD80_19220	COG1116	anion transmembrane transporter activity
HFD80_19225	COG1309	transcriptional regulator
HFD80_19230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFD80_19240	COG0196	riboflavin kinase activity
HFD80_19245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFD80_19255	COG1047	Peptidyl-prolyl cis-trans
HFD80_19295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFD80_19350	COG2951	lytic endotransglycosylase activity
HFD80_19355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFD80_19370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFD80_19380	COG0671	phosphoesterase, PA-phosphatase related
HFD80_19385	COG0861	Integral membrane protein TerC family
HFD80_19395	COG0754	glutathionylspermidine amidase activity
HFD80_19405	COG0402	S-adenosylhomocysteine deaminase activity
HFD80_19420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD80_19425	COG1230	cation diffusion facilitator family transporter
HFD80_19440	COG0706	membrane insertase activity
HFD80_19515	COG0358	DNA primase activity
HFD80_19570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HFD80_19615	COG0587	DNA-directed DNA polymerase activity
HFD80_19630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFD80_19630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HFD80_19680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HFD80_19680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFD80_19685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFD80_19725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD80_19765	COG2130	NADP-dependent
HFD80_19775	COG1309	transcriptional regulator
HFD80_19785	COG1902	pentaerythritol trinitrate reductase activity
HFD80_19795	COG1979	alcohol dehydrogenase
HFD80_19805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HFD80_19830	COG1063	alcohol dehydrogenase
HFD80_19910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFD80_19930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD80_20105	COG1525	nuclease
HFD80_20170	COG1475	DNA binding
HFD80_20185	COG3853	Toxic anion resistance protein (TelA)
HFD80_20320	COG3328	transposase activity
HFD80_20370	COG0741	lytic transglycosylase activity
HFD80_20405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process