locus-tag	class	description
HLG77_00010	COG0592	DNA-directed DNA polymerase activity
HLG77_00020	COG0187	DNA topoisomerase II activity
HLG77_00030	COG0586	Pfam SNARE associated Golgi protein
HLG77_00035	COG0488	(ABC) transporter
HLG77_00060	COG0596	Alpha beta hydrolase
HLG77_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLG77_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLG77_00110	COG0733	neurotransmitter:sodium symporter activity
HLG77_00145	COG0583	DNA-binding transcription factor activity
HLG77_00150	COG2233	PERMEase
HLG77_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG77_00200	COG2814	Major facilitator Superfamily
HLG77_00205	COG0656	L-ascorbic acid biosynthetic process
HLG77_00210	COG0583	DNA-binding transcription factor activity
HLG77_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG77_00230	COG1064	alcohol dehydrogenase
HLG77_00235	COG2818	Glycosylase
HLG77_00250	COG1194	a g-specific adenine glycosylase
HLG77_00270	COG2983	Belongs to the UPF0260 family
HLG77_00275	COG2133	pyrroloquinoline quinone binding
HLG77_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLG77_00285	COG2116	formate transmembrane transporter activity
HLG77_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG77_00310	COG1335	isochorismatase
HLG77_00315	COG0385	Bile acid
HLG77_00320	COG0534	Mate efflux family protein
HLG77_00325	COG1683	Conserved Protein
HLG77_00345	COG0625	glutathione transferase activity
HLG77_00355	COG1113	amino acid transport
HLG77_00365	COG0523	cobalamin synthesis protein
HLG77_00375	COG2188	Transcriptional regulator
HLG77_00405	COG0010	Belongs to the arginase family
HLG77_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG77_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLG77_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLG77_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HLG77_00530	COG0534	Mate efflux family protein
HLG77_00535	COG0436	Aminotransferase
HLG77_00540	COG2733	membrane
HLG77_00555	COG2918	glutathione biosynthetic process
HLG77_00575	COG3150	esterase
HLG77_00585	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_00590	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HLG77_00600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG77_00610	COG2233	PERMEase
HLG77_00615	COG2351	hydroxyisourate hydrolase activity
HLG77_00650	COG3706	GGDEF domain
HLG77_00665	COG1393	Belongs to the ArsC family
HLG77_00670	COG0708	Exodeoxyribonuclease III
HLG77_00700	COG0189	ligase activity
HLG77_00720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLG77_00730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLG77_00745	COG4942	peptidase
HLG77_00755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG77_00765	COG2119	membrane
HLG77_00770	COG4774	siderophore transport
HLG77_00775	COG0426	domain, Protein
HLG77_00775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG77_00800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLG77_00820	COG1902	pentaerythritol trinitrate reductase activity
HLG77_00825	COG1519	Transferase
HLG77_00830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLG77_00835	COG0668	transmembrane transport
HLG77_00845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG77_00850	COG1335	isochorismatase
HLG77_00855	COG1522	sequence-specific DNA binding
HLG77_00880	COG0784	Response regulator, receiver
HLG77_00880	COG2198	Histidine kinase
HLG77_00880	COG2205	protein histidine kinase activity
HLG77_00885	COG3162	membrane
HLG77_00890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG77_00900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG77_00910	COG3706	GGDEF domain
HLG77_00920	COG1309	transcriptional regulator
HLG77_00940	COG0352	thiamine-phosphate diphosphorylase activity
HLG77_00940	COG0351	phosphomethylpyrimidine kinase
HLG77_00940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG77_00950	COG2814	Major facilitator Superfamily
HLG77_00965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLG77_00975	COG1113	amino acid transport
HLG77_00985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLG77_00990	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_01000	COG1335	isochorismatase
HLG77_01110	COG2814	Major facilitator Superfamily
HLG77_01115	COG0583	DNA-binding transcription factor activity
HLG77_01125	COG3293	Transposase
HLG77_01140	COG0667	Aldo Keto reductase
HLG77_01165	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG77_01235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLG77_01285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLG77_01315	COG0427	acetyl-CoA hydrolase
HLG77_01330	COG0745	RESPONSE REGULATOR receiver
HLG77_01340	COG0659	secondary active sulfate transmembrane transporter activity
HLG77_01345	COG4221	oxidoreductase activity
HLG77_01350	COG2873	o-acetylhomoserine
HLG77_01355	COG0488	(ABC) transporter
HLG77_01440	COG0833	amino acid
HLG77_01485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLG77_01490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLG77_01505	COG2226	methyltransferase
HLG77_01555	COG0067	glutamate synthase
HLG77_01555	COG0069	glutamate synthase activity
HLG77_01555	COG0070	glutamate synthase
HLG77_01560	COG0493	'glutamate synthase
HLG77_01570	COG1704	LemA family
HLG77_01575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLG77_01590	COG3307	-O-antigen
HLG77_01610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG77_01625	COG0194	GDP metabolic process
HLG77_01675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLG77_01695	COG5380	lipid catabolic process
HLG77_01700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLG77_01725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG77_01730	COG0277	FAD linked oxidase domain protein
HLG77_01740	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HLG77_01760	COG1289	transmembrane transporter activity
HLG77_01770	COG0628	permease
HLG77_01775	COG1192	Involved in chromosome partitioning
HLG77_01805	COG0833	amino acid
HLG77_01810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG77_01815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG77_01825	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_01865	COG0583	DNA-binding transcription factor activity
HLG77_01910	COG0517	IMP dehydrogenase activity
HLG77_01915	COG1983	PspC domain protein
HLG77_01925	COG1960	acyl-CoA dehydrogenase activity
HLG77_01940	COG0408	coproporphyrinogen oxidase activity
HLG77_01960	COG0513	Belongs to the DEAD box helicase family
HLG77_01970	COG1127	ABC transporter
HLG77_01975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLG77_01985	COG2854	intermembrane phospholipid transfer
HLG77_01995	COG0598	Magnesium transport protein CorA
HLG77_02005	COG0494	nUDIX hydrolase
HLG77_02010	COG1040	competence protein
HLG77_02015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLG77_02035	COG1946	Acyl-CoA thioesterase
HLG77_02040	COG1301	dicarboxylic acid transport
HLG77_02055	COG1959	2 iron, 2 sulfur cluster binding
HLG77_02060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG77_02060	COG1017	nitric oxide dioxygenase activity
HLG77_02070	COG0433	COG0433 Predicted ATPase
HLG77_02075	COG0626	cystathionine gamma-synthase activity
HLG77_02230	COG1960	acyl-CoA dehydrogenase activity
HLG77_02235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLG77_02260	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HLG77_02265	COG0339	signal peptide processing
HLG77_02270	COG0557	exoribonuclease II activity
HLG77_02315	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG77_02320	COG2169	Transcriptional regulator
HLG77_02325	COG0697	spore germination
HLG77_02330	COG1295	ribonuclease BN
HLG77_02365	COG1702	phosphate starvation-inducible protein PhoH
HLG77_02375	COG1196	nuclear chromosome segregation
HLG77_02375	COG0741	lytic transglycosylase activity
HLG77_02375	COG0739	heme binding
HLG77_02405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLG77_02410	COG1183	phosphatidylcholine synthase activity
HLG77_02455	COG1960	acyl-CoA dehydrogenase activity
HLG77_02460	COG1309	transcriptional regulator
HLG77_02475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG77_02480	COG1960	acyl-CoA dehydrogenase activity
HLG77_02500	COG2969	positive regulation of protein catabolic process
HLG77_02510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLG77_02525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLG77_02530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLG77_02550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLG77_02560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG77_02565	COG1408	metallophosphoesterase
HLG77_02575	COG2199	diguanylate cyclase activity
HLG77_02635	COG1607	acyl-coa hydrolase
HLG77_02665	COG2350	Protein conserved in bacteria
HLG77_02675	COG0613	PHP domain protein
HLG77_02680	COG3781	membrane
HLG77_02690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLG77_02700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG77_02710	COG1862	Preprotein translocase
HLG77_02740	COG2205	protein histidine kinase activity
HLG77_02745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLG77_02760	COG0726	polysaccharide deacetylase
HLG77_02765	COG0438	transferase activity, transferring glycosyl groups
HLG77_02780	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLG77_02795	COG1215	transferase activity, transferring glycosyl groups
HLG77_02845	COG1960	acyl-CoA dehydrogenase activity
HLG77_02850	COG1960	acyl-CoA dehydrogenase activity
HLG77_02860	COG2205	protein histidine kinase activity
HLG77_02865	COG0745	RESPONSE REGULATOR receiver
HLG77_02870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLG77_02890	COG2096	Adenosyltransferase
HLG77_02940	COG0285	dihydrofolate synthase activity
HLG77_02960	COG0450	alkyl hydroperoxide reductase
HLG77_02975	COG0477	Major facilitator Superfamily
HLG77_02980	COG1272	protein, Hemolysin III
HLG77_03010	COG0183	Belongs to the thiolase family
HLG77_03015	COG2207	Transcriptional regulator
HLG77_03035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG77_03055	COG0183	Belongs to the thiolase family
HLG77_03065	COG2885	chlorophyll binding
HLG77_03065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HLG77_03075	COG1690	Belongs to the RtcB family
HLG77_03080	COG0833	amino acid
HLG77_03090	COG2233	PERMEase
HLG77_03120	COG2094	Belongs to the DNA glycosylase MPG family
HLG77_03125	COG4772	TonB-dependent receptor
HLG77_03130	COG1902	pentaerythritol trinitrate reductase activity
HLG77_03135	COG0679	Auxin Efflux Carrier
HLG77_03145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG77_03150	COG0354	folic acid binding
HLG77_03160	COG3189	MarR family transcriptional regulator
HLG77_03165	COG2824	Alkylphosphonate utilization operon protein PhnA
HLG77_03170	COG3422	double-strand break repair
HLG77_03210	COG0840	transmembrane signaling receptor activity
HLG77_03230	COG5510	response to toxic substance
HLG77_03240	COG2832	Protein of unknown function (DUF454)
HLG77_03245	COG1376	ErfK ybiS ycfS ynhG family protein
HLG77_03285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLG77_03295	COG1289	transmembrane transporter activity
HLG77_03320	COG1115	amino acid carrier protein
HLG77_03325	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLG77_03330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG77_03335	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HLG77_03340	COG3590	peptidase
HLG77_03370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG77_03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG77_03385	COG1077	Cell shape determining protein MreB Mrl
HLG77_03390	COG1792	Involved in formation and maintenance of cell shape
HLG77_03395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLG77_03400	COG0424	maF-like protein
HLG77_03405	COG1530	ribonuclease E activity
HLG77_03415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG77_03425	COG0560	Phosphoserine phosphatase
HLG77_03435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG77_03460	COG2207	Transcriptional regulator
HLG77_03490	COG1113	amino acid transport
HLG77_03495	COG2828	Protein conserved in bacteria
HLG77_03500	COG0142	geranyltranstransferase activity
HLG77_03505	COG2315	Protein conserved in bacteria
HLG77_03520	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLG77_03540	COG2194	sulfuric ester hydrolase activity
HLG77_03545	COG0745	RESPONSE REGULATOR receiver
HLG77_03550	COG0642	Histidine kinase
HLG77_03560	COG0004	ammonium transporteR
HLG77_03565	COG3293	Transposase
HLG77_03570	COG0583	DNA-binding transcription factor activity
HLG77_03590	COG0525	valine-tRNA ligase activity
HLG77_03600	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_03610	COG0393	Putative heavy-metal-binding
HLG77_03615	COG0393	Putative heavy-metal-binding
HLG77_03620	COG1538	Outer membrane efflux protein
HLG77_03630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG77_03635	COG0671	phosphoesterase, PA-phosphatase related
HLG77_03665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLG77_03680	COG1648	precorrin-2 dehydrogenase activity
HLG77_03680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLG77_03685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLG77_03690	COG1733	regulation of RNA biosynthetic process
HLG77_03700	COG0531	amino acid
HLG77_03715	COG0321	lipoyl(octanoyl) transferase activity
HLG77_03720	COG2921	Belongs to the UPF0250 family
HLG77_03755	COG2009	succinate dehydrogenase
HLG77_03760	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLG77_03765	COG1053	succinate dehydrogenase
HLG77_03770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG77_03795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG77_03815	COG2354	Protein conserved in bacteria
HLG77_03820	COG2321	neutral zinc metallopeptidase
HLG77_03850	COG0589	response to stress
HLG77_03860	COG0251	oxidation-reduction process
HLG77_03865	COG1309	transcriptional regulator
HLG77_03880	COG0505	Belongs to the CarA family
HLG77_03905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG77_03910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLG77_03965	COG0477	Major facilitator Superfamily
HLG77_03970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLG77_03985	COG1597	lipid kinase activity
HLG77_03990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG77_04010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG77_04015	COG0584	glycerophosphoryl diester phosphodiesterase
HLG77_04035	COG0741	lytic transglycosylase activity
HLG77_04055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLG77_04070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG77_04080	COG3811	Belongs to the UPF0386 family
HLG77_04095	COG1196	nuclear chromosome segregation
HLG77_04135	COG0778	Nitroreductase
HLG77_04140	COG0300	oxidoreductase activity
HLG77_04150	COG1929	Belongs to the glycerate kinase type-1 family
HLG77_04155	COG0243	molybdopterin cofactor binding
HLG77_04160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLG77_04165	COG3339	Conserved Protein
HLG77_04175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HLG77_04190	COG1113	amino acid transport
HLG77_04200	COG0019	diaminopimelate decarboxylase activity
HLG77_04215	COG2267	carboxylic ester hydrolase activity
HLG77_04220	COG1280	lysine exporter protein (LysE YggA)
HLG77_04225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLG77_04255	COG0463	Glycosyl transferase, family 2
HLG77_04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG77_04305	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLG77_04310	COG1136	(ABC) transporter
HLG77_04315	COG0658	competence protein
HLG77_04315	COG2333	competence protein COMEC
HLG77_04325	COG0616	signal peptide processing
HLG77_04325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLG77_04330	COG0596	Alpha beta hydrolase
HLG77_04335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLG77_04345	COG0628	permease
HLG77_04385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG77_04405	COG0823	Involved in the tonB-independent uptake of proteins
HLG77_04425	COG0824	Thioesterase
HLG77_04430	COG1473	amidohydrolase
HLG77_04450	COG0047	phosphoribosylformylglycinamidine synthase activity
HLG77_04450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLG77_04455	COG2814	Major facilitator Superfamily
HLG77_04465	COG1024	Enoyl-CoA hydratase
HLG77_04470	COG1051	belongs to the nudix hydrolase family
HLG77_04470	COG1056	cytidyltransferase-related domain
HLG77_04480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLG77_04495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLG77_04510	COG4625	pathogenesis
HLG77_04515	COG0583	DNA-binding transcription factor activity
HLG77_04520	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLG77_04525	COG4208	sulfate ABC transporter
HLG77_04530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLG77_04540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLG77_04545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLG77_04550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLG77_04585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG77_04595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLG77_04605	COG0681	Belongs to the peptidase S26 family
HLG77_04620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLG77_04630	COG1381	Involved in DNA repair and RecF pathway recombination
HLG77_04635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLG77_04645	COG4221	oxidoreductase activity
HLG77_04675	COG0436	Aminotransferase
HLG77_04695	COG0556	nucleotide-excision repair
HLG77_04735	COG1196	nuclear chromosome segregation
HLG77_04800	COG2070	2-Nitropropane dioxygenase
HLG77_04830	COG1215	transferase activity, transferring glycosyl groups
HLG77_04860	COG0415	Belongs to the DNA photolyase family
HLG77_04870	COG1252	NADH dehydrogenase
HLG77_04875	COG1686	Belongs to the peptidase S11 family
HLG77_04890	COG1187	pseudouridine synthase activity
HLG77_04915	COG0477	Major facilitator Superfamily
HLG77_04920	COG0583	DNA-binding transcription factor activity
HLG77_04935	COG0612	Peptidase, M16
HLG77_04960	COG0352	thiamine-phosphate diphosphorylase activity
HLG77_04995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG77_05005	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG77_05020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLG77_05025	COG0076	glutamate decarboxylase activity
HLG77_05035	COG1522	sequence-specific DNA binding
HLG77_05040	COG3961	Belongs to the TPP enzyme family
HLG77_05045	COG1113	amino acid transport
HLG77_05050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLG77_05055	COG0573	inorganic phosphate transmembrane transporter activity
HLG77_05065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLG77_05070	COG0616	signal peptide processing
HLG77_05105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLG77_05110	COG1686	Belongs to the peptidase S11 family
HLG77_05135	COG0583	DNA-binding transcription factor activity
HLG77_05140	COG1067	ATP-dependent peptidase activity
HLG77_05165	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLG77_05185	COG1966	Carbon starvation protein
HLG77_05190	COG2879	small protein
HLG77_05225	COG1741	Belongs to the pirin family
HLG77_05235	COG2964	Protein conserved in bacteria
HLG77_05250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG77_05255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG77_05260	COG4605	iron ion homeostasis
HLG77_05265	COG4604	ABC transporter, ATP-binding protein
HLG77_05270	COG4607	ABC-type enterochelin transport system periplasmic component
HLG77_05275	COG4774	siderophore transport
HLG77_05285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG77_05290	COG1021	2,3-dihydroxybenzoate-AMP ligase
HLG77_05295	COG3433	isochorismatase activity
HLG77_05295	COG1535	isochorismatase
HLG77_05310	COG1132	(ABC) transporter
HLG77_05315	COG5265	(ABC) transporter
HLG77_05320	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HLG77_05345	COG3739	integral membrane protein
HLG77_05375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLG77_05405	COG0308	aminopeptidase N
HLG77_05410	COG0512	Glutamine amidotransferase of anthranilate synthase
HLG77_05420	COG3104	oligopeptide transport
HLG77_05425	COG0174	glutamine synthetase
HLG77_05435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLG77_05470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLG77_05475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLG77_05480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG77_05500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLG77_05505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLG77_05510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HLG77_05525	COG1960	acyl-CoA dehydrogenase activity
HLG77_05530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG77_05535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG77_05545	COG2223	nitrite transmembrane transporter activity
HLG77_05555	COG0024	Methionine aminopeptidase
HLG77_05560	COG0052	Belongs to the universal ribosomal protein uS2 family
HLG77_05575	COG2207	Transcriptional regulator
HLG77_05600	COG2951	lytic endotransglycosylase activity
HLG77_05605	COG0772	Belongs to the SEDS family
HLG77_05620	COG0842	Transport permease protein
HLG77_05625	COG1131	(ABC) transporter
HLG77_05630	COG0582	viral genome integration into host DNA
HLG77_05945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG77_05960	COG4215	(ABC) transporter
HLG77_05965	COG4160	amino acid transport
HLG77_05970	COG4598	ABC transporter
HLG77_05980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLG77_05990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG77_06005	COG1720	tRNA m6t6A37 methyltransferase activity
HLG77_06025	COG0745	RESPONSE REGULATOR receiver
HLG77_06030	COG0642	Histidine kinase
HLG77_06040	COG0494	nUDIX hydrolase
HLG77_06050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG77_06055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLG77_06060	COG3139	Protein of unknown function (DUF1315)
HLG77_06070	COG1301	dicarboxylic acid transport
HLG77_06075	COG1960	acyl-CoA dehydrogenase activity
HLG77_06080	COG2819	hydrolase of the alpha beta superfamily
HLG77_06090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLG77_06100	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLG77_06120	COG1690	Belongs to the RtcB family
HLG77_06125	COG1234	tRNA 3'-trailer cleavage
HLG77_06130	COG4650	regulator
HLG77_06160	COG2363	Small membrane protein
HLG77_06180	COG0513	Belongs to the DEAD box helicase family
HLG77_06190	COG0778	Nitroreductase
HLG77_06220	COG1286	toxin biosynthetic process
HLG77_06245	COG4783	chaperone-mediated protein folding
HLG77_06250	COG1610	YqeY-like protein
HLG77_06280	COG2815	serine threonine protein kinase
HLG77_06280	COG0515	serine threonine protein kinase
HLG77_06350	COG3111	PFAM Bacterial OB fold (BOF) protein
HLG77_06375	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLG77_06380	COG0786	glutamate:sodium symporter activity
HLG77_06390	COG2186	Transcriptional regulator
HLG77_06440	COG0477	Major facilitator Superfamily
HLG77_06445	COG1051	belongs to the nudix hydrolase family
HLG77_06485	COG2995	paraquat-inducible protein a
HLG77_06490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLG77_06490	COG3008	intermembrane lipid transfer
HLG77_06510	COG1794	racemase activity, acting on amino acids and derivatives
HLG77_06540	COG1301	dicarboxylic acid transport
HLG77_06555	COG2011	ABC-type metal ion transport system permease component
HLG77_06560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG77_06565	COG1464	Belongs to the NlpA lipoprotein family
HLG77_06570	COG0151	Belongs to the GarS family
HLG77_06575	COG0138	bifunctional purine biosynthesis protein purh
HLG77_06580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HLG77_06610	COG2308	Evidence 4 Homologs of previously reported genes of
HLG77_06620	COG1305	Transglutaminase-like
HLG77_06630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLG77_06635	COG0305	Participates in initiation and elongation during chromosome replication
HLG77_06660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLG77_06670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLG77_06675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLG77_06700	COG0726	polysaccharide deacetylase
HLG77_06700	COG1649	PFAM Uncharacterised BCR, COG1649
HLG77_06705	COG1215	transferase activity, transferring glycosyl groups
HLG77_06710	COG3658	cytochrome
HLG77_06720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG77_06755	COG1960	acyl-CoA dehydrogenase activity
HLG77_06760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG77_06765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG77_06790	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HLG77_06795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HLG77_06805	COG2205	protein histidine kinase activity
HLG77_06810	COG0745	RESPONSE REGULATOR receiver
HLG77_06815	COG0174	glutamine synthetase
HLG77_06830	COG0477	Major facilitator Superfamily
HLG77_06835	COG0729	surface antigen
HLG77_06860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLG77_06865	COG2814	Major facilitator Superfamily
HLG77_06890	COG0583	DNA-binding transcription factor activity
HLG77_06905	COG1187	pseudouridine synthase activity
HLG77_06925	COG0802	atpase or kinase
HLG77_06930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLG77_06940	COG1923	regulation of RNA biosynthetic process
HLG77_06945	COG0697	spore germination
HLG77_06970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG77_06975	COG0519	Catalyzes the synthesis of GMP from XMP
HLG77_06975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLG77_06980	COG4302	ethanolamine ammonia-lyase activity
HLG77_06985	COG4303	Ethanolamine ammonia lyase large subunit
HLG77_06990	COG0531	amino acid
HLG77_07010	COG1454	alcohol dehydrogenase
HLG77_07015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLG77_07040	COG0308	aminopeptidase N
HLG77_07080	COG1605	Chorismate mutase
HLG77_07105	COG1309	transcriptional regulator
HLG77_07115	COG0668	transmembrane transport
HLG77_07145	COG4773	Receptor
HLG77_07165	COG0488	(ABC) transporter
HLG77_07170	COG0589	response to stress
HLG77_07195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLG77_07205	COG3135	benzoate transporter
HLG77_07210	COG1522	sequence-specific DNA binding
HLG77_07220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG77_07225	COG0583	DNA-binding transcription factor activity
HLG77_07235	COG0183	Belongs to the thiolase family
HLG77_07245	COG2030	dehydratase
HLG77_07265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLG77_07280	COG0824	Thioesterase
HLG77_07285	COG1454	alcohol dehydrogenase
HLG77_07295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLG77_07315	COG0069	glutamate synthase activity
HLG77_07480	COG5410	chromosome segregation
HLG77_07660	COG1063	alcohol dehydrogenase
HLG77_07665	COG3293	Transposase
HLG77_07680	COG2814	Major facilitator Superfamily
HLG77_07695	COG0511	ligase activity, forming carbon-carbon bonds
HLG77_07715	COG1116	anion transmembrane transporter activity
HLG77_07715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG77_07720	COG0745	RESPONSE REGULATOR receiver
HLG77_07730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG77_07730	COG2146	nitrite reductase [NAD(P)H] activity
HLG77_07735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG77_07740	COG0243	molybdopterin cofactor binding
HLG77_07750	COG0243	molybdopterin cofactor binding
HLG77_07755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLG77_07770	COG0315	cyclic pyranopterin monophosphate synthase activity
HLG77_07770	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLG77_07775	COG0303	'Molybdopterin
HLG77_07785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG77_07790	COG0697	spore germination
HLG77_07810	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HLG77_07815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG77_07870	COG2204	response regulator
HLG77_07875	COG3852	Histidine kinase
HLG77_07895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG77_07900	COG0575	Belongs to the CDS family
HLG77_07915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG77_07935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLG77_07950	COG2137	regulation of response to DNA damage stimulus
HLG77_07960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLG77_07965	COG1011	Hydrolase
HLG77_07990	COG1522	sequence-specific DNA binding
HLG77_08000	COG1113	amino acid transport
HLG77_08015	COG0659	secondary active sulfate transmembrane transporter activity
HLG77_08020	COG2135	peptidase activity
HLG77_08035	COG3300	MHYT domain
HLG77_08035	COG5001	Diguanylate cyclase
HLG77_08055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLG77_08055	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLG77_08055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLG77_08060	COG1105	Belongs to the carbohydrate kinase PfkB family
HLG77_08065	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG77_08065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG77_08095	COG0024	Methionine aminopeptidase
HLG77_08100	COG0583	DNA-binding transcription factor activity
HLG77_08110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLG77_08115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG77_08120	COG0516	GMP reductase activity
HLG77_08120	COG0517	IMP dehydrogenase activity
HLG77_08145	COG0552	protein localization to endoplasmic reticulum
HLG77_08155	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HLG77_08170	COG4890	Cyd operon protein YbgT
HLG77_08175	COG1294	oxidase, subunit
HLG77_08190	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLG77_08200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG77_08205	COG4774	siderophore transport
HLG77_08220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG77_08225	COG0569	domain protein
HLG77_08230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG77_08260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLG77_08265	COG0542	response to heat
HLG77_08290	COG1902	pentaerythritol trinitrate reductase activity
HLG77_08290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG77_08335	COG2323	membrane
HLG77_08340	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLG77_08350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLG77_08355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG77_08360	COG0183	Belongs to the thiolase family
HLG77_08365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLG77_08370	COG0596	Alpha beta hydrolase
HLG77_08375	COG2271	Major facilitator Superfamily
HLG77_08380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG77_08385	COG3485	protocatechuate 3,4-dioxygenase
HLG77_08390	COG3485	protocatechuate 3,4-dioxygenase
HLG77_08395	COG0710	3-dehydroquinate dehydratase activity
HLG77_08400	COG3420	alginic acid biosynthetic process
HLG77_08405	COG3659	wide pore channel activity
HLG77_08410	COG4993	Dehydrogenase
HLG77_08420	COG2391	methyltransferase activity
HLG77_08435	COG1414	Transcriptional regulator
HLG77_08440	COG0583	DNA-binding transcription factor activity
HLG77_08445	COG1960	acyl-CoA dehydrogenase activity
HLG77_08470	COG2814	Major facilitator Superfamily
HLG77_08480	COG0154	amidase activity
HLG77_08500	COG4638	Rieske (2fe-2S)
HLG77_08510	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_08520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG77_08530	COG3733	amine oxidase
HLG77_08540	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_08550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG77_08560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG77_08565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLG77_08575	COG4829	muconolactone delta-isomerase
HLG77_08580	COG4948	Mandelate Racemase Muconate Lactonizing
HLG77_08585	COG0583	DNA-binding transcription factor activity
HLG77_08595	COG2186	Transcriptional regulator
HLG77_08615	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_08630	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG77_08630	COG1902	pentaerythritol trinitrate reductase activity
HLG77_08670	COG1309	transcriptional regulator
HLG77_08675	COG0583	DNA-binding transcription factor activity
HLG77_08680	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_08685	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_08690	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_08700	COG1960	acyl-CoA dehydrogenase activity
HLG77_08710	COG0318	PFAM AMP-dependent synthetase and ligase
HLG77_08750	COG2188	Transcriptional regulator
HLG77_08765	COG0583	DNA-binding transcription factor activity
HLG77_08795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG77_08820	COG1566	PFAM secretion protein HlyD family protein
HLG77_08835	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_08840	COG0129	dihydroxy-acid dehydratase activity
HLG77_08850	COG0583	DNA-binding transcription factor activity
HLG77_08855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG77_08865	COG2084	Dehydrogenase
HLG77_08870	COG2207	Transcriptional regulator
HLG77_08875	COG1064	alcohol dehydrogenase
HLG77_08890	COG1120	ATPase activity
HLG77_08925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLG77_08975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLG77_09020	COG0084	hydrolase, TatD family'
HLG77_09035	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_09050	COG2207	Transcriptional regulator
HLG77_09060	COG2205	protein histidine kinase activity
HLG77_09065	COG0745	RESPONSE REGULATOR receiver
HLG77_09070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG77_09075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG77_09105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG77_09115	COG3250	beta-galactosidase activity
HLG77_09125	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HLG77_09135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG77_09135	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HLG77_09145	COG3293	Transposase
HLG77_09175	COG2161	toxin-antitoxin pair type II binding
HLG77_09210	COG3539	Fimbrial protein
HLG77_09235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HLG77_09245	COG0753	catalase activity
HLG77_09260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG77_09325	COG1535	isochorismatase
HLG77_09325	COG3433	isochorismatase activity
HLG77_09330	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_09335	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLG77_09340	COG4149	molybdate abc transporter
HLG77_09345	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLG77_09355	COG4638	Rieske (2fe-2S)
HLG77_09360	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLG77_09365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG77_09365	COG0543	2 iron, 2 sulfur cluster binding
HLG77_09390	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_09405	COG2207	Transcriptional regulator
HLG77_09415	COG3293	Transposase
HLG77_09425	COG2610	gluconate transmembrane transporter activity
HLG77_09450	COG0583	DNA-binding transcription factor activity
HLG77_09465	COG2031	fatty acid transporter
HLG77_09470	COG0183	Belongs to the thiolase family
HLG77_09475	COG0583	DNA-binding transcription factor activity
HLG77_09480	COG0583	DNA-binding transcription factor activity
HLG77_09495	COG1027	Aspartate ammonia-lyase
HLG77_09505	COG0477	Major facilitator Superfamily
HLG77_09525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG77_09530	COG4521	taurine ABC transporter
HLG77_09545	COG2188	Transcriptional regulator
HLG77_09555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLG77_09560	COG1733	regulation of RNA biosynthetic process
HLG77_09565	COG3708	Transcriptional regulator
HLG77_09565	COG2207	Transcriptional regulator
HLG77_09580	COG0730	response to heat
HLG77_09590	COG3453	Protein conserved in bacteria
HLG77_09590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG77_09600	COG3781	membrane
HLG77_09605	COG1063	alcohol dehydrogenase
HLG77_09615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG77_09620	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG77_09625	COG0022	dehydrogenase e1 component
HLG77_09630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLG77_09635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG77_09655	COG3706	GGDEF domain
HLG77_09670	COG0133	tryptophan synthase activity
HLG77_09680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG77_09725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLG77_09750	COG2226	methyltransferase
HLG77_09805	COG0842	Transport permease protein
HLG77_09810	COG0842	Transport permease protein
HLG77_09815	COG1131	(ABC) transporter
HLG77_09830	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLG77_09835	COG4773	Receptor
HLG77_09855	COG0730	response to heat
HLG77_09860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLG77_09875	COG0406	alpha-ribazole phosphatase activity
HLG77_09880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLG77_09925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG77_09935	COG4264	IucA IucC family
HLG77_09940	COG4264	IucA IucC family
HLG77_09960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLG77_09975	COG1960	acyl-CoA dehydrogenase activity
HLG77_09980	COG1960	acyl-CoA dehydrogenase activity
HLG77_09985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG77_09990	COG2207	Transcriptional regulator
HLG77_09995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG77_10000	COG0776	regulation of translation
HLG77_10025	COG0822	iron-sulfur transferase activity
HLG77_10030	COG0316	Belongs to the HesB IscA family
HLG77_10060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLG77_10080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG77_10085	COG0702	epimerase
HLG77_10120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG77_10130	COG0339	signal peptide processing
HLG77_10180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLG77_10185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLG77_10215	COG0776	regulation of translation
HLG77_10280	COG0084	hydrolase, TatD family'
HLG77_10300	COG1663	tetraacyldisaccharide 4'-kinase activity
HLG77_10305	COG1132	(ABC) transporter
HLG77_10315	COG0811	peptide transport
HLG77_10320	COG1475	DNA binding
HLG77_10325	COG1192	Involved in chromosome partitioning
HLG77_10335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLG77_10350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG77_10355	COG0191	fructose-bisphosphate aldolase activity
HLG77_10375	COG0424	maF-like protein
HLG77_10380	COG2850	peptidyl-arginine hydroxylation
HLG77_10390	COG0640	Transcriptional regulator
HLG77_10400	COG3619	membrane
HLG77_10405	COG3122	Protein conserved in bacteria
HLG77_10410	COG1132	(ABC) transporter
HLG77_10430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLG77_10435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG77_10445	COG0506	proline dehydrogenase activity
HLG77_10445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLG77_10445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLG77_10450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLG77_10465	COG3698	Phosphodiester glycosidase
HLG77_10475	COG2353	YceI-like domain
HLG77_10485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLG77_10530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLG77_10530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLG77_10555	COG3539	Fimbrial protein
HLG77_10560	COG3121	Chaperone
HLG77_10605	COG0697	spore germination
HLG77_10635	COG0583	DNA-binding transcription factor activity
HLG77_10655	COG1309	transcriptional regulator
HLG77_10670	COG1522	sequence-specific DNA binding
HLG77_10680	COG1126	abc transporter atp-binding protein
HLG77_10685	COG0765	amino acid transport
HLG77_10690	COG0765	amino acid transport
HLG77_10720	COG1464	Belongs to the NlpA lipoprotein family
HLG77_10730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG77_10735	COG2011	ABC-type metal ion transport system permease component
HLG77_10740	COG0012	GTP binding
HLG77_10765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLG77_10805	COG0386	Belongs to the glutathione peroxidase family
HLG77_10815	COG0436	Aminotransferase
HLG77_10855	COG3634	alkyl hydroperoxide reductase activity
HLG77_10870	COG0583	DNA-binding transcription factor activity
HLG77_10875	COG0798	PFAM Bile acid sodium symporter
HLG77_10880	COG0640	Transcriptional regulator
HLG77_10895	COG3328	transposase activity
HLG77_10900	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLG77_10910	COG0583	DNA-binding transcription factor activity
HLG77_10920	COG1953	Uracil, thiamine, allantoin
HLG77_10930	COG2175	clavaminate synthase activity
HLG77_10935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG77_10940	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLG77_10945	COG4521	taurine ABC transporter
HLG77_10955	COG0477	Major facilitator Superfamily
HLG77_10975	COG1271	oxidase subunit
HLG77_10980	COG1294	oxidase, subunit
HLG77_10990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG77_11010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLG77_11030	COG3052	prosthetic group binding
HLG77_11035	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HLG77_11045	COG0583	DNA-binding transcription factor activity
HLG77_11055	COG2814	Major facilitator Superfamily
HLG77_11075	COG1346	cytolysis
HLG77_11085	COG0583	DNA-binding transcription factor activity
HLG77_11090	COG0625	glutathione transferase activity
HLG77_11095	COG0625	glutathione transferase activity
HLG77_11100	COG0583	DNA-binding transcription factor activity
HLG77_11115	COG1045	serine acetyltransferase
HLG77_11120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLG77_11125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLG77_11130	COG1280	lysine exporter protein (LysE YggA)
HLG77_11140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG77_11145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG77_11155	COG0765	amino acid transport
HLG77_11160	COG0765	amino acid transport
HLG77_11180	COG0784	Response regulator, receiver
HLG77_11180	COG2205	protein histidine kinase activity
HLG77_11200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLG77_11220	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_11270	COG0583	DNA-binding transcription factor activity
HLG77_11290	COG0318	PFAM AMP-dependent synthetase and ligase
HLG77_11295	COG1309	transcriptional regulator
HLG77_11300	COG1960	acyl-CoA dehydrogenase activity
HLG77_11305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG77_11310	COG1024	Enoyl-CoA hydratase
HLG77_11315	COG4770	biotin carboxylase activity
HLG77_11325	COG0583	DNA-binding transcription factor activity
HLG77_11340	COG1960	acyl-CoA dehydrogenase activity
HLG77_11350	COG2814	Major facilitator Superfamily
HLG77_11360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG77_11365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLG77_11370	COG2814	Major facilitator Superfamily
HLG77_11375	COG1960	acyl-CoA dehydrogenase activity
HLG77_11380	COG1024	Enoyl-CoA hydratase
HLG77_11385	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_11390	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG77_11395	COG0183	Belongs to the thiolase family
HLG77_11405	COG2814	Major facilitator Superfamily
HLG77_11415	COG1024	Enoyl-CoA hydratase
HLG77_11430	COG1960	acyl-CoA dehydrogenase activity
HLG77_11435	COG2814	Major facilitator Superfamily
HLG77_11440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG77_11445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLG77_11460	COG3842	ATPase activity
HLG77_11465	COG1840	ABC-type Fe3 transport system, periplasmic component
HLG77_11475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG77_11480	COG1414	Transcriptional regulator
HLG77_11490	COG0583	DNA-binding transcription factor activity
HLG77_11495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG77_11500	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_11510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLG77_11520	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_11525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG77_11530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG77_11535	COG2267	carboxylic ester hydrolase activity
HLG77_11555	COG3038	cytochrome b561
HLG77_11560	COG0753	catalase activity
HLG77_11565	COG2271	Major facilitator Superfamily
HLG77_11570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG77_11575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG77_11590	COG2207	Transcriptional regulator
HLG77_11635	COG2050	protein possibly involved in aromatic compounds catabolism
HLG77_11645	COG3327	negative regulation of DNA-templated transcription, initiation
HLG77_11670	COG0038	chloride channel
HLG77_11675	COG4770	biotin carboxylase activity
HLG77_11695	COG1914	H( )-stimulated, divalent metal cation uptake system
HLG77_11700	COG0583	DNA-binding transcription factor activity
HLG77_11730	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG77_11750	COG2814	Major facilitator Superfamily
HLG77_11760	COG1560	Kdo2-lipid A biosynthetic process
HLG77_11770	COG5006	permease, DMT superfamily
HLG77_11775	COG1522	sequence-specific DNA binding
HLG77_11790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HLG77_11800	COG4122	O-methyltransferase activity
HLG77_11830	COG1538	Outer membrane efflux protein
HLG77_11840	COG3293	Transposase
HLG77_11845	COG1137	ATPase activity
HLG77_11850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HLG77_11860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HLG77_11905	COG2814	Major facilitator Superfamily
HLG77_11940	COG1278	Cold shock
HLG77_11945	COG1280	lysine exporter protein (LysE YggA)
HLG77_11975	COG1570	exodeoxyribonuclease VII activity
HLG77_12025	COG0583	DNA-binding transcription factor activity
HLG77_12030	COG4638	Rieske (2fe-2S)
HLG77_12035	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLG77_12040	COG0633	Ferredoxin
HLG77_12040	COG0543	2 iron, 2 sulfur cluster binding
HLG77_12045	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_12050	COG3135	benzoate transporter
HLG77_12055	COG2814	Major facilitator Superfamily
HLG77_12070	COG1643	Atp-dependent helicase
HLG77_12075	COG3293	Transposase
HLG77_12080	COG0450	alkyl hydroperoxide reductase
HLG77_12090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HLG77_12100	COG3634	alkyl hydroperoxide reductase activity
HLG77_12120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLG77_12130	COG3328	transposase activity
HLG77_12150	COG0625	glutathione transferase activity
HLG77_12160	COG2885	chlorophyll binding
HLG77_12195	COG0542	response to heat
HLG77_12210	COG1765	OsmC-like protein
HLG77_12220	COG0667	Aldo Keto reductase
HLG77_12235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLG77_12245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLG77_12255	COG0582	viral genome integration into host DNA
HLG77_12490	COG0527	aspartate kinase activity
HLG77_12500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLG77_12510	COG3038	cytochrome b561
HLG77_12520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLG77_12525	COG2252	PERMEase
HLG77_12535	COG2072	flavoprotein involved in K transport
HLG77_12570	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_12590	COG0531	amino acid
HLG77_12600	COG1113	amino acid transport
HLG77_12640	COG2801	Transposase and inactivated derivatives
HLG77_12645	COG2801	Transposase and inactivated derivatives
HLG77_12660	COG4269	membrane
HLG77_12675	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG77_12675	COG1902	pentaerythritol trinitrate reductase activity
HLG77_12685	COG2203	Gaf domain
HLG77_12685	COG3706	GGDEF domain
HLG77_12685	COG4251	negative regulation of phosphorylation
HLG77_12685	COG5001	Diguanylate cyclase
HLG77_12695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLG77_12715	COG3293	Transposase
HLG77_12720	COG4172	Belongs to the ABC transporter superfamily
HLG77_12725	COG4239	(ABC) transporter, permease
HLG77_12730	COG4174	ABC transporter (Permease)
HLG77_12740	COG0741	lytic transglycosylase activity
HLG77_12740	COG1388	LysM domain
HLG77_12740	COG0741	lytic transglycosylase activity
HLG77_12740	COG1388	LysM domain
HLG77_12745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLG77_12785	COG0583	DNA-binding transcription factor activity
HLG77_12790	COG1279	arginine transmembrane transporter activity
HLG77_12810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG77_12815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG77_12820	COG0006	proline dipeptidase activity
HLG77_12860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLG77_12875	COG3328	transposase activity
HLG77_12900	COG3384	dioxygenase
HLG77_12910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG77_12915	COG2878	Part of a membrane complex involved in electron transport
HLG77_12920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLG77_12945	COG0768	penicillin binding
HLG77_12950	COG0742	ribosomal rna small subunit methyltransferase
HLG77_12965	COG0830	nickel cation binding
HLG77_12975	COG0804	urea catabolic process
HLG77_13020	COG1253	flavin adenine dinucleotide binding
HLG77_13025	COG2851	Citrate transporter
HLG77_13070	COG1773	rubredoxin
HLG77_13075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG77_13085	COG0583	DNA-binding transcription factor activity
HLG77_13115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLG77_13120	COG4181	ATPase activity
HLG77_13165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLG77_13185	COG0306	phosphate transporter
HLG77_13195	COG3958	Transketolase
HLG77_13200	COG3959	Transketolase, thiamine diphosphate binding domain
HLG77_13205	COG2271	Major facilitator Superfamily
HLG77_13210	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_13215	COG0583	DNA-binding transcription factor activity
HLG77_13230	COG2223	nitrite transmembrane transporter activity
HLG77_13235	COG2207	Transcriptional regulator
HLG77_13240	COG2066	Belongs to the glutaminase family
HLG77_13245	COG0242	peptide deformylase activity
HLG77_13250	COG0477	Major facilitator Superfamily
HLG77_13260	COG0028	Belongs to the TPP enzyme family
HLG77_13275	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_13280	COG2267	carboxylic ester hydrolase activity
HLG77_13290	COG2271	Major facilitator Superfamily
HLG77_13295	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG77_13305	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_13325	COG1414	Transcriptional regulator
HLG77_13340	COG1024	Enoyl-CoA hydratase
HLG77_13350	COG1215	transferase activity, transferring glycosyl groups
HLG77_13355	COG1649	PFAM Uncharacterised BCR, COG1649
HLG77_13355	COG0726	polysaccharide deacetylase
HLG77_13365	COG4681	YaeQ
HLG77_13375	COG0523	cobalamin synthesis protein
HLG77_13385	COG1607	acyl-coa hydrolase
HLG77_13395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG77_13400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG77_13405	COG1309	transcriptional regulator
HLG77_13430	COG2040	homocysteine
HLG77_13435	COG0531	amino acid
HLG77_13480	COG3328	transposase activity
HLG77_13495	COG0405	Gamma-glutamyltransferase
HLG77_13500	COG2814	Major facilitator Superfamily
HLG77_13510	COG2050	protein possibly involved in aromatic compounds catabolism
HLG77_13525	COG1090	epimerase
HLG77_13545	COG0420	3'-5' exonuclease activity
HLG77_13570	COG0735	belongs to the Fur family
HLG77_13575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG77_13595	COG0121	glutamine amidotransferase
HLG77_13610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG77_13620	COG0210	DNA helicase
HLG77_13625	COG2885	chlorophyll binding
HLG77_13630	COG0204	Acyl-transferase
HLG77_13645	COG2894	cell division
HLG77_13660	COG1280	lysine exporter protein (LysE YggA)
HLG77_13665	COG1674	ftsk spoiiie
HLG77_13665	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLG77_13670	COG0492	ferredoxin-NADP+ reductase activity
HLG77_13675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLG77_13685	COG0456	acetyltransferase
HLG77_13745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLG77_13745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLG77_13765	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_13785	COG0473	3-isopropylmalate dehydrogenase activity
HLG77_13790	COG0583	DNA-binding transcription factor activity
HLG77_13810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLG77_13835	COG0564	pseudouridine synthase activity
HLG77_13845	COG0358	DNA primase activity
HLG77_13860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HLG77_13890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLG77_13920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLG77_13930	COG0352	thiamine-phosphate diphosphorylase activity
HLG77_13930	COG0351	phosphomethylpyrimidine kinase
HLG77_13930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG77_13935	COG1652	LysM domain
HLG77_13960	COG1399	metal-binding, possibly nucleic acid-binding protein
HLG77_13965	COG3101	peptidyl-lysine hydroxylation
HLG77_13970	COG0009	L-threonylcarbamoyladenylate synthase
HLG77_13975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLG77_13980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLG77_14000	COG4106	trans-aconitate 2-methyltransferase activity
HLG77_14015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG77_14015	COG0596	Alpha beta hydrolase
HLG77_14015	COG2226	methyltransferase
HLG77_14020	COG1877	trehalose-phosphatase activity
HLG77_14025	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HLG77_14030	COG2223	nitrite transmembrane transporter activity
HLG77_14050	COG1196	nuclear chromosome segregation
HLG77_14060	COG0730	response to heat
HLG77_14075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLG77_14085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG77_14135	COG0489	protein tyrosine kinase activity
HLG77_14145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG77_14145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG77_14175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLG77_14180	COG2081	HI0933 family
HLG77_14190	COG0668	transmembrane transport
HLG77_14210	COG0583	DNA-binding transcription factor activity
HLG77_14230	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG77_14235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG77_14265	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLG77_14300	COG2205	protein histidine kinase activity
HLG77_14305	COG0745	RESPONSE REGULATOR receiver
HLG77_14325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLG77_14360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG77_14375	COG0583	DNA-binding transcription factor activity
HLG77_14385	COG0583	DNA-binding transcription factor activity
HLG77_14400	COG0583	DNA-binding transcription factor activity
HLG77_14405	COG1053	succinate dehydrogenase
HLG77_14420	COG1309	transcriptional regulator
HLG77_14425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG77_14430	COG2814	Major facilitator Superfamily
HLG77_14435	COG1960	acyl-CoA dehydrogenase activity
HLG77_14440	COG0583	DNA-binding transcription factor activity
HLG77_14445	COG1063	alcohol dehydrogenase
HLG77_14475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLG77_14480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLG77_14485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG77_14505	COG2132	Multicopper oxidase
HLG77_14515	COG0561	phosphatase activity
HLG77_14520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLG77_14530	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLG77_14545	COG1214	PFAM Peptidase M22, glycoprotease
HLG77_14580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLG77_14585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLG77_14590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLG77_14650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLG77_14660	COG1846	Transcriptional regulator
HLG77_14665	COG1764	response to oxidative stress
HLG77_14705	COG0037	tRNA processing
HLG77_14715	COG0248	Ppx GppA phosphatase
HLG77_14745	COG0072	phenylalanine-tRNA ligase activity
HLG77_14785	COG1238	metal cluster binding
HLG77_14790	COG0625	glutathione transferase activity
HLG77_14805	COG0318	PFAM AMP-dependent synthetase and ligase
HLG77_14810	COG3028	Belongs to the UPF0307 family
HLG77_14815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG77_14835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLG77_14840	COG0617	tRNA 3'-terminal CCA addition
HLG77_14845	COG1555	photosystem II stabilization
HLG77_14850	COG3956	TIGRFAM MazG family protein
HLG77_14860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG77_14880	COG2205	protein histidine kinase activity
HLG77_14880	COG0784	Response regulator, receiver
HLG77_14880	COG5002	protein histidine kinase activity
HLG77_14885	COG1024	Enoyl-CoA hydratase
HLG77_14890	COG2084	Dehydrogenase
HLG77_14895	COG3622	Belongs to the hyi family
HLG77_14925	COG0697	spore germination
HLG77_14935	COG2814	Major facilitator Superfamily
HLG77_14940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG77_14950	COG0583	DNA-binding transcription factor activity
HLG77_14960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLG77_14970	COG0084	hydrolase, TatD family'
HLG77_14985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLG77_15025	COG0440	acetolactate synthase activity
HLG77_15030	COG0028	Belongs to the TPP enzyme family
HLG77_15055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG77_15060	COG1136	(ABC) transporter
HLG77_15060	COG0577	efflux transmembrane transporter activity
HLG77_15065	COG1538	Outer membrane efflux protein
HLG77_15080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLG77_15085	COG1162	GTPase activity
HLG77_15095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLG77_15135	COG1426	Protein conserved in bacteria
HLG77_15170	COG0793	Belongs to the peptidase S41A family
HLG77_15185	COG2267	carboxylic ester hydrolase activity
HLG77_15195	COG1012	belongs to the aldehyde dehydrogenase family
HLG77_15200	COG3265	gluconokinase activity
HLG77_15210	COG0800	Aldolase
HLG77_15220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLG77_15225	COG0280	phosphate acetyltransferase
HLG77_15225	COG0857	belongs to the CobB CobQ family
HLG77_15230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG77_15230	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG77_15250	COG0740	serine-type endopeptidase activity
HLG77_15260	COG4774	siderophore transport
HLG77_15270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG77_15280	COG2813	Specifically methylates the guanine in position
HLG77_15280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG77_15380	COG0788	formyltetrahydrofolate deformylase activity
HLG77_15405	COG4651	solute:proton antiporter activity
HLG77_15405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLG77_15425	COG0724	RNA recognition motif
HLG77_15430	COG0210	DNA helicase
HLG77_15455	COG1733	regulation of RNA biosynthetic process
HLG77_15465	COG2900	Belongs to the SlyX family
HLG77_15485	COG1560	Kdo2-lipid A biosynthetic process
HLG77_15495	COG1301	dicarboxylic acid transport
HLG77_15500	COG3293	Transposase
HLG77_15555	COG0473	3-isopropylmalate dehydrogenase activity
HLG77_15610	COG0583	DNA-binding transcription factor activity
HLG77_15620	COG0625	glutathione transferase activity
HLG77_15625	COG2378	regulation of single-species biofilm formation
HLG77_15630	COG0546	phosphoglycolate phosphatase activity
HLG77_15645	COG1530	ribonuclease E activity
HLG77_15650	COG0318	PFAM AMP-dependent synthetase and ligase
HLG77_15675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLG77_15685	COG0534	Mate efflux family protein
HLG77_15700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLG77_15740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HLG77_15745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG77_15760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG77_15770	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HLG77_15770	COG0644	oxidoreductase
HLG77_15775	COG0425	Belongs to the sulfur carrier protein TusA family
HLG77_15780	COG4535	Mg2 and Co2 transporter CorC
HLG77_15790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG77_15810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLG77_15815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLG77_15815	COG0475	glutathione-regulated potassium exporter activity
HLG77_15830	COG0484	heat shock protein binding
HLG77_15835	COG0789	Transcriptional regulator
HLG77_15840	COG0598	Magnesium transport protein CorA
HLG77_15860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLG77_15865	COG1074	ATP-dependent DNA helicase activity
HLG77_15870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HLG77_15890	COG2226	methyltransferase
HLG77_15905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG77_15910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLG77_15925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG77_15925	COG2111	Na H antiporter
HLG77_15930	COG1006	Multisubunit Na H antiporter MnhC subunit
HLG77_15935	COG0651	ATP synthesis coupled electron transport
HLG77_15945	COG2212	antiporter activity
HLG77_15965	COG0195	Participates in both transcription termination and antitermination
HLG77_16015	COG0237	dephospho-CoA kinase activity
HLG77_16025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG77_16040	COG0497	DNA recombination
HLG77_16050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLG77_16080	COG2169	Transcriptional regulator
HLG77_16080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG77_16085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLG77_16095	COG3328	transposase activity
HLG77_16160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLG77_16175	COG0326	Molecular chaperone. Has ATPase activity
HLG77_16190	COG2056	Na+-H+ antiporter family
HLG77_16290	COG0546	phosphoglycolate phosphatase activity
HLG77_16295	COG1716	ATPase activity
HLG77_16340	COG0181	hydroxymethylbilane synthase activity
HLG77_16355	COG3293	Transposase
HLG77_16380	COG1538	Outer membrane efflux protein
HLG77_16385	COG0697	spore germination
HLG77_16410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG77_16415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLG77_16420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG77_16425	COG0772	Belongs to the SEDS family
HLG77_16450	COG4974	Belongs to the 'phage' integrase family
HLG77_16455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG77_16465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLG77_16475	COG2197	response regulator
HLG77_16490	COG0793	Belongs to the peptidase S41A family
HLG77_16495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLG77_16500	COG0795	lipopolysaccharide-transporting ATPase activity
HLG77_16540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLG77_16540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLG77_16550	COG0004	ammonium transporteR
HLG77_16555	COG0347	Belongs to the P(II) protein family
HLG77_16565	COG0606	chelatase, subunit chli
HLG77_16595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLG77_16625	COG3293	Transposase
HLG77_16665	COG2132	Multicopper oxidase
HLG77_16680	COG2205	protein histidine kinase activity
HLG77_16735	COG0606	chelatase, subunit chli
HLG77_16740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG77_16750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG77_16765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLG77_16780	COG0318	PFAM AMP-dependent synthetase and ligase
HLG77_16790	COG0477	Major facilitator Superfamily
HLG77_16795	COG2860	membrane
HLG77_16805	COG1253	flavin adenine dinucleotide binding
HLG77_16815	COG2814	Major facilitator Superfamily
HLG77_16825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLG77_16860	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLG77_16870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLG77_16915	COG1309	transcriptional regulator
HLG77_16950	COG0758	DNA mediated transformation
HLG77_16960	COG0697	spore germination
HLG77_17035	COG1121	(ABC) transporter
HLG77_17040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG77_17045	COG1280	lysine exporter protein (LysE YggA)
HLG77_17050	COG2837	iron assimilation
HLG77_17055	COG0281	malic enzyme
HLG77_17100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLG77_17100	COG0519	Catalyzes the synthesis of GMP from XMP
HLG77_17105	COG4399	Belongs to the UPF0754 family
HLG77_17110	COG2259	Doxx family
HLG77_17115	COG0586	Pfam SNARE associated Golgi protein
HLG77_17130	COG1192	Involved in chromosome partitioning
HLG77_17140	COG0271	Belongs to the BolA IbaG family
HLG77_17180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HLG77_17180	COG3321	synthase
HLG77_17180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLG77_17180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLG77_17185	COG1960	acyl-CoA dehydrogenase activity
HLG77_17195	COG2197	response regulator
HLG77_17205	COG3916	Acyl-homoserine-lactone synthase
HLG77_17210	COG0477	Major facilitator Superfamily
HLG77_17215	COG1024	Enoyl-CoA hydratase
HLG77_17220	COG1024	Enoyl-CoA hydratase
HLG77_17225	COG1960	acyl-CoA dehydrogenase activity
HLG77_17230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG77_17250	COG1113	amino acid transport
HLG77_17255	COG1113	amino acid transport
HLG77_17260	COG0251	oxidation-reduction process
HLG77_17310	COG0564	pseudouridine synthase activity
HLG77_17375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLG77_17390	COG1802	Transcriptional regulator
HLG77_17400	COG1448	Aminotransferase
HLG77_17405	COG0277	FAD linked oxidase domain protein
HLG77_17415	COG2186	Transcriptional regulator
HLG77_17425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG77_17435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG77_17450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLG77_17455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLG77_17460	COG1216	Glycosyl transferase, family 2
HLG77_17485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLG77_17490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLG77_17495	COG1596	polysaccharide export
HLG77_17520	COG0728	peptidoglycan biosynthetic process
HLG77_17525	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLG77_17580	COG0546	phosphoglycolate phosphatase activity
HLG77_17585	COG1028	Short-chain dehydrogenase reductase Sdr
HLG77_17605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG77_17610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG77_17615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG77_17620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG77_17625	COG1116	anion transmembrane transporter activity
HLG77_17630	COG1309	transcriptional regulator
HLG77_17635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLG77_17645	COG0196	riboflavin kinase activity
HLG77_17650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLG77_17660	COG1047	Peptidyl-prolyl cis-trans
HLG77_17700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLG77_17770	COG2951	lytic endotransglycosylase activity
HLG77_17775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLG77_17790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLG77_17800	COG0671	phosphoesterase, PA-phosphatase related
HLG77_17805	COG0861	Integral membrane protein TerC family
HLG77_17815	COG0754	glutathionylspermidine amidase activity
HLG77_17825	COG0402	S-adenosylhomocysteine deaminase activity
HLG77_17860	COG1230	cation diffusion facilitator family transporter
HLG77_17875	COG0706	membrane insertase activity
HLG77_17900	COG1309	transcriptional regulator
HLG77_17910	COG1902	pentaerythritol trinitrate reductase activity
HLG77_17920	COG1979	alcohol dehydrogenase
HLG77_17935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLG77_17965	COG0477	Major facilitator Superfamily
HLG77_17970	COG0697	spore germination
HLG77_17980	COG3321	synthase
HLG77_17980	COG0604	alcohol dehydrogenase
HLG77_17985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HLG77_18010	COG2801	Transposase and inactivated derivatives
HLG77_18025	COG2801	Transposase and inactivated derivatives
HLG77_18030	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HLG77_18055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HLG77_18065	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HLG77_18105	COG3328	transposase activity
HLG77_18175	COG2816	NAD+ diphosphatase activity
HLG77_18180	COG3046	protein related to deoxyribodipyrimidine photolyase
HLG77_18195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG77_18220	COG1192	Involved in chromosome partitioning
HLG77_18275	COG0667	Aldo Keto reductase
HLG77_18325	COG4716	Myosin-crossreactive antigen
HLG77_18365	COG2801	Transposase and inactivated derivatives
HLG77_18375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG77_18380	COG0501	Belongs to the peptidase M48B family
HLG77_18410	COG0542	response to heat
HLG77_18440	COG0582	viral genome integration into host DNA
HLG77_18465	COG0583	DNA-binding transcription factor activity
HLG77_18475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG77_18510	COG1660	Displays ATPase and GTPase activities
HLG77_18545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG77_18550	COG2963	transposase activity
HLG77_18560	COG4372	Transposase
HLG77_18590	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HLG77_18655	COG3451	type IV secretory pathway VirB4
HLG77_18675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLG77_18725	COG1192	Involved in chromosome partitioning
HLG77_18775	COG2826	transposase and inactivated derivatives, IS30 family
HLG77_18795	COG0673	inositol 2-dehydrogenase activity
HLG77_18800	COG1324	tolerance protein
HLG77_18835	COG2194	sulfuric ester hydrolase activity
HLG77_18850	COG0406	alpha-ribazole phosphatase activity