locus-tag class description HLG75_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HLG75_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLG75_00030 ENOG4105DQR SNARE associated Golgi HLG75_00035 ENOG4105C5H ABC transporter HLG75_00040 ENOG4108821 RND type efflux pump HLG75_00045 ENOG4108821 RND type efflux pump HLG75_00050 ENOG4108821 RND type efflux pump HLG75_00060 ENOG4105D74 hydrolase HLG75_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HLG75_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HLG75_00110 ENOG4105C8J )-transporter HLG75_00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HLG75_00150 ENOG4105C2W permease HLG75_00160 ENOG4108IG5 Transcriptional regulator HLG75_00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit HLG75_00200 ENOG4105F27 Major Facilitator HLG75_00205 ENOG4105CV8 reductase HLG75_00210 ENOG4105HEI LysR family (Transcriptional regulator HLG75_00230 ENOG4105DQ4 alcohol dehydrogenase HLG75_00235 ENOG4108R3E Dna-3-methyladenine glycosylase i HLG75_00250 ENOG4105CEN a g-specific adenine glycosylase HLG75_00270 ENOG4108ZZ3 UPF0260 protein HLG75_00280 ENOG4105D1H recombination factor protein RarA HLG75_00285 ENOG4105S64 Formate nitrite transporter HLG75_00305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLG75_00310 ENOG4108RWI nicotinamidase HLG75_00315 ENOG4105C09 Bile acid HLG75_00320 ENOG4107QI1 Mate efflux family protein HLG75_00325 ENOG4105EWC Purine nucleoside phosphorylase HLG75_00345 ENOG4108RXX maleylacetoacetate isomerase HLG75_00355 ENOG4105C85 amino acid HLG75_00365 ENOG4105CKI cobalamin synthesis protein HLG75_00375 ENOG4105CZE histidine utilization repressor HLG75_00395 ENOG4105C85 amino acid HLG75_00405 ENOG41088SP formiminoglutamate hydrolase HLG75_00425 ENOG4108NIW Leucine export protein LeuE HLG75_00440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HLG75_00450 ENOG4108ZAI phosphatidylglycerophosphatase a HLG75_00455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HLG75_00470 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HLG75_00515 ENOG4105KHC sulfurtransferase HLG75_00530 ENOG4105BZU Histidine kinase HLG75_00535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLG75_00550 ENOG4107QJQ Mate efflux family protein HLG75_00555 ENOG4105CHM Aminotransferase HLG75_00560 ENOG4106BRA Membrane HLG75_00575 ENOG4105D9M gamma-glutamylcysteine synthetase HLG75_00585 ENOG4105CS6 Rhs element vgr protein HLG75_00610 ENOG4105F9F transposase HLG75_00625 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HLG75_00630 ENOG4105EPC oxidoreductase HLG75_00635 ENOG4105VF7 tolerance protein HLG75_00640 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HLG75_00660 ENOG4105F9F transposase HLG75_00685 ENOG4105IPS esterase HLG75_00690 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLG75_00695 ENOG4108Z2U ureidoglycolate hydrolase HLG75_00705 ENOG41061H0 Monooxygenase HLG75_00720 ENOG41084YZ Hydrolase HLG75_00750 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HLG75_00755 ENOG4105BZU Histidine kinase HLG75_00770 ENOG4105KUZ arsenate reductase HLG75_00775 ENOG4105CGK Exodeoxyribonuclease III HLG75_00800 ENOG4105D7Z glutathione synthase HLG75_00820 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HLG75_00825 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HLG75_00830 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HLG75_00845 ENOG41063SB peptidase HLG75_00850 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HLG75_00855 ENOG4107QSN dihydrolipoamide acetyltransferase HLG75_00885 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HLG75_00900 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HLG75_00920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLG75_00925 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HLG75_00935 ENOG4105D64 Mechanosensitive ion channel HLG75_00945 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLG75_00950 ENOG4108W2Y isochorismatase HLG75_00960 ENOG4105FBW Monooxygenase HLG75_00965 ENOG4108UZX fmn reductase HLG75_00980 ENOG4105BZU Histidine kinase HLG75_00985 ENOG41062QD Membrane HLG75_00990 ENOG4107QN1 sodium solute HLG75_01000 ENOG4105C94 Transporter HLG75_01010 ENOG4105BZU Histidine kinase HLG75_01015 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLG75_01020 ENOG4108WUH Transcriptional regulator, TetR family HLG75_01025 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HLG75_01035 ENOG4105RA2 Membrane HLG75_01040 ENOG4105DWF phosphomethylpyrimidine kinase HLG75_01050 ENOG4107RDB Major Facilitator HLG75_01055 ENOG4108UUM single-stranded DNA-binding protein HLG75_01065 ENOG4108UMN azlc family HLG75_01075 ENOG4105C85 amino acid HLG75_01085 ENOG4108JPW Aminotransferase HLG75_01090 ENOG4105C26 Dehydrogenase HLG75_01100 ENOG4105CHJ isochorismatase hydrolase HLG75_01105 ENOG4105EUB pirin domain protein HLG75_01140 ENOG4105D94 Major Facilitator Superfamily HLG75_01145 ENOG4106NZI LysR family Transcriptional regulator HLG75_01165 ENOG4105CPC Aldo Keto reductase HLG75_01170 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HLG75_01190 ENOG4105KVH Transcriptional regulator HLG75_01220 ENOG4105KVH Transcriptional regulator HLG75_01225 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HLG75_01245 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HLG75_01250 ENOG4108UQN AraC family transcriptional regulator HLG75_01305 ENOG4105CUV Homoserine Kinase HLG75_01320 ENOG41061CK Antibiotic biosynthesis monooxygenase HLG75_01350 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HLG75_01375 ENOG4108R6G acetyltransferase HLG75_01380 ENOG4105CYC Transferase HLG75_01390 ENOG4105E0F Histidine kinase HLG75_01400 ENOG4105BZM domain protein HLG75_01405 ENOG4105CHH sulfate transporter HLG75_01410 ENOG4105PDP Short chain dehydrogenase HLG75_01435 ENOG4105C5H ABC transporter HLG75_01500 ENOG4108IQI permease HLG75_01525 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HLG75_01540 ENOG4105CJN penicillin-binding protein HLG75_01545 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HLG75_01550 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HLG75_01565 ENOG4105DHI Methyltransferase HLG75_01570 ENOG4108JQC penicillin-binding protein 1A HLG75_01595 ENOG4105E4G Type IV pilus HLG75_01615 ENOG4105CBC glutamate synthase HLG75_01620 ENOG4105BZ8 glutamate synthase HLG75_01630 ENOG4108V0P LemA family HLG75_01635 ENOG4105HA9 of methanol dehydrogenase type HLG75_01650 ENOG4108YSG O-Antigen polymerase HLG75_01655 ENOG4108UQY Iron-storage protein HLG75_01665 ENOG4105KME endoribonuclease L-psp HLG75_01670 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HLG75_01685 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HLG75_01735 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HLG75_01750 ENOG4107IFA Lipase (EC 3.1.1.3) HLG75_01755 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HLG75_01760 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HLG75_01785 ENOG4108JQ1 Dehydrogenase HLG75_01790 ENOG4105CQB FAD linked oxidase domain protein HLG75_01800 ENOG4105VRH Antibiotic biosynthesis monooxygenase HLG75_01805 ENOG4105NF4 modulator of drug activity HLG75_01825 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLG75_01830 ENOG4105IPI Membrane HLG75_01835 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HLG75_01865 ENOG4108IQI permease HLG75_01870 ENOG4105D82 Glutamate dehydrogenase HLG75_01875 ENOG4105C8Y Acetylornithine aminotransferase HLG75_01885 ENOG4105C26 Dehydrogenase HLG75_01975 ENOG4105W87 Cbs domain HLG75_01980 ENOG41067S9 phage shock protein C, PspC HLG75_01990 ENOG4105CSU acyl-Coa dehydrogenase HLG75_02005 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HLG75_02020 ENOG4105ECY inositol monophosphatase HLG75_02025 ENOG4105C1J atp-dependent rna helicase HLG75_02035 ENOG4105DHJ ABC, transporter HLG75_02040 ENOG4105CY3 ABC transporter, permease HLG75_02050 ENOG4105E3I toluene tolerance HLG75_02060 ENOG4105D7N magnesium and cobalt transport protein CorA HLG75_02065 ENOG4108URH decarboxylase HLG75_02075 ENOG4105MJ2 Competence protein HLG75_02080 ENOG4105CB5 ATP-dependent DNA helicase recG HLG75_02100 ENOG4105C29 acyl-CoA thioesterase HLG75_02105 ENOG4105CK2 sodium dicarboxylate symporter HLG75_02120 ENOG4105KPV Transcriptional regulator HLG75_02135 ENOG4105D7A ATP-binding protein HLG75_02145 ENOG41089BK Glutamine amido-transferase HLG75_02255 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HLG75_02295 ENOG4105C1G acyl-Coa dehydrogenase HLG75_02330 ENOG4105VKU nucleicacid-binding protein HLG75_02335 ENOG4105DGW oligopeptidase A HLG75_02340 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HLG75_02385 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HLG75_02390 ENOG4108K2B transcriptional regulator HLG75_02400 ENOG4107S2Z UPF0761 membrane protein HLG75_02405 ENOG4105CS1 NAD(P)H quinone oxidoreductase HLG75_02435 ENOG4105C9A Phoh family HLG75_02445 ENOG4105E4C Lytic transglycosylase catalytic HLG75_02475 ENOG4105D6S protein involved in catabolism of external DNA HLG75_02480 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HLG75_02525 ENOG4105C1G acyl-Coa dehydrogenase HLG75_02530 ENOG4108RZE Tetr family transcriptional regulator HLG75_02545 ENOG4107QX3 carboxylase HLG75_02550 ENOG4105C1G acyl-Coa dehydrogenase HLG75_02570 ENOG4105KB2 stringent starvation protein b HLG75_02575 ENOG4107MKT Stringent starvation protein a HLG75_02580 ENOG4108UJD 30S ribosomal protein S9 HLG75_02590 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HLG75_02595 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HLG75_02600 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HLG75_02620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HLG75_02630 ENOG4107RZC phospholipase d HLG75_02640 ENOG4105UYK outer membrane protein a HLG75_02645 ENOG4108KHX Diguanylate cyclase HLG75_02695 ENOG4107U2T alpha beta HLG75_02705 ENOG4105NAU thioesterase Superfamily protein HLG75_02735 ENOG4105K9H YciI-like protein HLG75_02745 ENOG4105DB7 PHP domain protein HLG75_02750 ENOG4105FFC UPF0187 protein HLG75_02760 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HLG75_02765 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HLG75_02770 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HLG75_02775 ENOG4105VIE preprotein translocase, subunit YajC HLG75_02855 ENOG4105BZU Histidine kinase HLG75_02860 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HLG75_02865 ENOG4105CM2 brancheD-chain amino acid aminotransferase HLG75_02880 ENOG4107BJW polysaccharide deacetylase HLG75_02890 ENOG4108PQP glycosyl transferase group 1 HLG75_02905 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HLG75_02930 ENOG4105UGU tonB-dependent Receptor HLG75_02950 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HLG75_02955 ENOG4105CSU acyl-Coa dehydrogenase HLG75_02960 ENOG4105CSU acyl-Coa dehydrogenase HLG75_02970 ENOG4105EB3 Histidine kinase HLG75_02975 ENOG4105E3W Two component transcriptional regulator (Winged helix family HLG75_02980 ENOG4105CNG UPF0061 protein HLG75_03000 ENOG4108WBT adenosyltransferase HLG75_03005 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HLG75_03050 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HLG75_03070 ENOG4105D3R alkyl hydroperoxide reductase HLG75_03085 ENOG4105CSH Transporter HLG75_03090 ENOG4108UT2 hemolysin iii HLG75_03100 ENOG41082BV acetyltransferase HLG75_03120 ENOG4105CHU acetyl-coa acetyltransferase HLG75_03125 ENOG4108R6W Transcriptional regulator, ARAC family HLG75_03135 ENOG4105TW1 Carbohydrate-selective porin OprB HLG75_03140 ENOG4105DZG Dehydrogenase HLG75_03145 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HLG75_03165 ENOG4105CHU acetyl-coa acetyltransferase HLG75_03175 ENOG4108WHA ompa motb domain protein HLG75_03185 ENOG4105E0Y RtcB Protein HLG75_03190 ENOG4108IQI permease HLG75_03200 ENOG4105C2W permease HLG75_03205 ENOG4105CI3 gtp-binding protein typa HLG75_03220 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLG75_03230 ENOG4108VX5 3-methyladenine DNA glycosylase HLG75_03235 ENOG4105CHB tonB-dependent Receptor HLG75_03240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLG75_03245 ENOG4108N2Y auxin Efflux HLG75_03255 ENOG4105T95 Thiol disulfide interChange protein HLG75_03260 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HLG75_03270 ENOG4105K78 MarR family Transcriptional regulator HLG75_03275 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HLG75_03280 ENOG4105KWI UPF0339 protein HLG75_03305 ENOG4108UNF response regulator HLG75_03310 ENOG4105M3Z response regulator HLG75_03315 ENOG4108ZGA chew protein HLG75_03320 ENOG4105C8Q Methyl-accepting chemotaxis HLG75_03325 ENOG4105CBS Chea signal transduction histidine kinase HLG75_03340 ENOG4107PEH Entericidin EcnA/B family HLG75_03350 ENOG4105WD1 Membrane HLG75_03355 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLG75_03405 ENOG4105EM2 membrane HLG75_03410 ENOG4105C2C drug resistance transporter, Bcr CflA HLG75_03430 ENOG4105BZG amino acid carrier protein HLG75_03435 ENOG4105D78 K07001 NTE family protein HLG75_03440 ENOG4105C7B Threonine dehydratase HLG75_03450 ENOG4105C9K Endothelin-converting enzyme 1 HLG75_03475 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HLG75_03485 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HLG75_03495 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HLG75_03500 ENOG4105VQ7 Rod shape-determining protein MreD HLG75_03505 ENOG4108Z03 MAF-like protein HLG75_03510 ENOG4105C03 ribonuclease HLG75_03520 ENOG4105D8T Acyltransferase HLG75_03530 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HLG75_03540 ENOG4108X0B nad(p)h dehydrogenase (quinone) HLG75_03565 ENOG4105CF7 AraC family transcriptional regulator HLG75_03585 ENOG4105C85 amino acid HLG75_03590 ENOG4105C7F AcnD-accessory protein PrpF HLG75_03595 ENOG4105CTB Polyprenyl synthetase HLG75_03600 ENOG4105MSB protein, conserved in bacteria HLG75_03615 ENOG4105D78 K07001 NTE family protein HLG75_03635 ENOG4105DIJ Phosphoethanolamine transferase HLG75_03640 ENOG4105XJC Two component transcriptional regulator (Winged helix family HLG75_03645 ENOG4105DHQ Histidine kinase HLG75_03660 ENOG4108M0I Transcriptional regulator HLG75_03680 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HLG75_03700 ENOG4105K8R UPF0145 protein HLG75_03705 ENOG4105K8R UPF0145 protein HLG75_03710 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HLG75_03715 ENOG4105BZS acriflavin resistance protein HLG75_03720 ENOG4105C1P efflux transporter, rnd family, mfp subunit HLG75_03725 ENOG410841Q phosphoesterase PA-phosphatase related protein HLG75_03755 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HLG75_03770 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HLG75_03775 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HLG75_03780 ENOG4105KVH Transcriptional regulator HLG75_03790 ENOG4105CUB amino acid HLG75_03805 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HLG75_03810 ENOG41084BA UPF0250 protein HLG75_03815 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLG75_03850 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HLG75_03855 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HLG75_03865 ENOG4105E33 succinate dehydrogenase HLG75_03880 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HLG75_03885 ENOG4105C7S Dehydrogenase HLG75_03890 ENOG4107QN2 dihydrolipoyl dehydrogenase HLG75_03900 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HLG75_03915 ENOG4105CGZ zinc metallopeptidase HLG75_03920 ENOG4105EEQ Na H antiporter HLG75_03935 ENOG4105PNM synthesis protein HLG75_03950 ENOG41080TK Universal stress protein HLG75_03960 ENOG4108UQ8 endoribonuclease L-psp HLG75_03965 ENOG4108IG5 Transcriptional regulator HLG75_03975 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HLG75_03980 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HLG75_03995 ENOG4105HBR Rna-binding protein HLG75_04005 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HLG75_04010 ENOG4105EEI dihydropteroate synthase HLG75_04060 ENOG4105CSH Transporter HLG75_04065 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HLG75_04070 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HLG75_04085 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HLG75_04100 ENOG41080IJ Diacylglycerol kinase HLG75_04110 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HLG75_04115 ENOG4105BZS acriflavin resistance protein HLG75_04130 ENOG4105E4C Lytic transglycosylase catalytic HLG75_04150 ENOG4108RRZ Transcription elongation factor GreB HLG75_04160 ENOG4105DFP Integrase HLG75_04185 ENOG4105R8C Transcriptional regulator HLG75_04250 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_04260 ENOG4105YCT UPF0386 protein HLG75_04330 ENOG4105BZW Glycerate kinase HLG75_04335 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HLG75_04340 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HLG75_04355 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HLG75_04365 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HLG75_04370 ENOG4105C85 amino acid HLG75_04380 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HLG75_04390 ENOG4105N14 lysine exporter protein LysE YggA HLG75_04395 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLG75_04400 ENOG4105BZJ Electron transfer flavoprotein HLG75_04405 ENOG4105C10 Electron transfer flavoprotein HLG75_04410 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLG75_04445 ENOG4107KET secretion protein, HlyD family HLG75_04480 ENOG4105D60 lipoprotein releasing system transmembrane protein HLG75_04485 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HLG75_04490 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HLG75_04500 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HLG75_04505 ENOG4107R6F Alpha Beta Hydrolase Fold protein HLG75_04510 ENOG4108V3E phosphoribosylglycinamide formyltransferase HLG75_04520 ENOG4105C02 permease HLG75_04570 ENOG4105KCK Peptidoglycan-associated lipoprotein HLG75_04575 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HLG75_04585 ENOG4105M8F Biopolymer transport protein exbD tolR HLG75_04590 ENOG4105E02 MotA TolQ exbB proton channel HLG75_04595 ENOG4107YD3 Thioesterase HLG75_04600 ENOG4105CH2 amidohydrolase HLG75_04620 ENOG4108ETH Formylglycinamide ribotide synthetase HLG75_04625 ENOG4105C2C drug resistance transporter, Bcr CflA HLG75_04635 ENOG4108UKI Enoyl-CoA hydratase HLG75_04650 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLG75_04665 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HLG75_04670 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HLG75_04685 ENOG4107R11 Transcriptional regulator HLG75_04690 ENOG4108IJ6 ABC transporter HLG75_04700 ENOG4108I5D sulfate abc transporter HLG75_04710 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HLG75_04715 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HLG75_04720 ENOG4105HHA aminodeoxychorismate lyase HLG75_04735 ENOG4108IYU L-aspartate oxidase HLG75_04740 ENOG4105C0H protease HLG75_04750 ENOG41068WN HLG75_04760 ENOG4105C3F Signal peptidase i HLG75_04775 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HLG75_04785 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HLG75_04790 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HLG75_04795 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HLG75_04800 ENOG4105EMU Dehydrogenase HLG75_04830 ENOG4105F7F Chaperone HLG75_04850 ENOG4105BZU Histidine kinase HLG75_04860 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HLG75_04870 ENOG4105DTR rard protein HLG75_04905 ENOG4107QS8 (LipO)protein HLG75_04910 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HLG75_04915 ENOG4105EA8 2-Nitropropane dioxygenase HLG75_04945 ENOG4107R8N Glycosyl transferase, family 2 HLG75_04960 ENOG4105CVP deoxyribo-dipyrimidine photolyase HLG75_04965 ENOG4108YZY peptidylprolyl cis-trans isomerase HLG75_04970 ENOG4105CEP NADH dehydrogenase HLG75_04975 ENOG4105DZ1 carboxypeptidase HLG75_04985 ENOG4105E9K Isocitrate dehydrogenase HLG75_04990 ENOG4108R99 pseudouridine synthase HLG75_05015 ENOG4105CBP Major Facilitator HLG75_05020 ENOG4105EGI Transcriptional regulator HLG75_05025 ENOG4108ETY sodium dicarboxylate symporter HLG75_05030 ENOG4105JAB phenazine biosynthesis protein, phzf family HLG75_05060 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HLG75_05075 ENOG4105D3G Pseudouridine synthase HLG75_05080 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HLG75_05095 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HLG75_05105 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HLG75_05120 ENOG4108JPW Aminotransferase HLG75_05125 ENOG4105DY8 decarboxylase HLG75_05135 ENOG4105F7P transcriptional regulator AsnC family HLG75_05140 ENOG4107RA9 decarboxylase HLG75_05145 ENOG4105C85 amino acid HLG75_05150 ENOG4105CVA phosphate HLG75_05155 ENOG4105C8U phosphate abc transporter HLG75_05165 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HLG75_05170 ENOG4105ERU peptidase HLG75_05185 ENOG4107QTF adenylosuccinate lyase HLG75_05205 ENOG4108Z0R Transferase HLG75_05210 ENOG4105DZ1 carboxypeptidase HLG75_05230 ENOG4108K5P (LipO)protein HLG75_05235 ENOG4105EJC lysr family transcriptional regulator HLG75_05240 ENOG4105DAN ATP-dependent protease HLG75_05255 ENOG4105DHU Bile acid HLG75_05265 ENOG41066DG (EAL) domain protein HLG75_05275 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HLG75_05285 ENOG4105D22 carbon starvation protein HLG75_05290 ENOG4105VCD cytoplasmic protein HLG75_05330 ENOG4105CHJ isochorismatase hydrolase HLG75_05335 ENOG4105CR8 Transcriptional regulator HLG75_05345 ENOG4107RN6 Monooxygenase HLG75_05350 ENOG4105D74 hydrolase HLG75_05400 ENOG4105C2I pirin domain protein HLG75_05410 ENOG4105WWK YheO domain protein HLG75_05425 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_05440 ENOG4108IPW abc transporter atp-binding protein HLG75_05460 ENOG4105C0W non-ribosomal peptide synthetase HLG75_05465 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HLG75_05470 ENOG4105WQI isochorismatase HLG75_05485 ENOG4105BZ1 (ABC) transporter HLG75_05520 ENOG4105NX3 Membrane HLG75_05540 ENOG4105EUJ GTP cyclohydrolase i HLG75_05550 ENOG4105C7W Xanthine dehydrogenase HLG75_05580 ENOG4105CD8 aminopeptidase N HLG75_05585 ENOG4105DDQ anthranilate synthase HLG75_05595 ENOG4105DUX Transporter HLG75_05610 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HLG75_05645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLG75_05650 ENOG4107QNR UPF0135 protein HLG75_05655 ENOG4105C0H protease HLG75_05665 ENOG4105C6K Malic enzyme HLG75_05670 ENOG4105BZU Histidine kinase HLG75_05675 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HLG75_05680 ENOG4105SYT Methylenetetrahydrofolate reductase HLG75_05685 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HLG75_05700 ENOG4107QPN acyl-Coa dehydrogenase HLG75_05705 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HLG75_05710 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HLG75_05720 ENOG4107RNU major facilitator superfamily MFS_1 HLG75_05730 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLG75_05735 ENOG4105CE9 30S ribosomal protein S2 HLG75_05775 ENOG4105CVE Lytic murein transglycosylase HLG75_05780 ENOG4105CNI cell division protein FtsW HLG75_05795 ENOG4105E3A (ABC) transporter HLG75_05800 ENOG4105DA5 (ABC) transporter HLG75_05940 ENOG4105MEW serine threonine protein phosphatase HLG75_06185 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HLG75_06195 ENOG4105ENT Efflux transporter rnd family, mfp subunit HLG75_06205 ENOG4105E89 ABC transporter HLG75_06210 ENOG4105DSP amino acid AbC transporter HLG75_06215 ENOG4106YG3 ABC transporter HLG75_06220 ENOG4108JEH abc transporter atp-binding protein HLG75_06230 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HLG75_06235 ENOG4105CFP Peptidase U32 HLG75_06240 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLG75_06245 ENOG4105JAB phenazine biosynthesis protein, phzf family HLG75_06250 ENOG4105DP0 ferredoxin-NADP reductase HLG75_06255 ENOG4108R96 Methyltransferase, YaeB family HLG75_06265 ENOG4107QHF type ii secretion system protein e HLG75_06275 ENOG4105XJC Two component transcriptional regulator (Winged helix family HLG75_06280 ENOG4105DHQ Histidine kinase HLG75_06290 ENOG4105M6F mutator MutT protein HLG75_06300 ENOG4105BZ4 penicillin-binding protein HLG75_06305 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HLG75_06310 ENOG4105VUT cytoplasmic protein HLG75_06315 ENOG4108I0Q anthranilate phosphoribosyltransferase HLG75_06320 ENOG4105CK2 sodium dicarboxylate symporter HLG75_06325 ENOG4105C1G acyl-Coa dehydrogenase HLG75_06330 ENOG4105NIV Esterase HLG75_06335 ENOG4105CQC Prephenate dehydratase HLG75_06340 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HLG75_06350 ENOG4105CIN aminoacyl-histidine dipeptidase HLG75_06370 ENOG4105E0Y RtcB Protein HLG75_06375 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HLG75_06380 ENOG4105CYB regulatoR HLG75_06410 ENOG4105M08 Membrane HLG75_06415 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLG75_06425 ENOG4105VEQ Cold shock protein HLG75_06430 ENOG4105C1J atp-dependent rna helicase HLG75_06440 ENOG41069NU Nitroreductase HLG75_06475 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HLG75_06490 ENOG4105C5I Dehydrogenase HLG75_06495 ENOG4105ERG peptidase m48, ste24p HLG75_06500 ENOG4105KTH gatB Yqey HLG75_06530 ENOG4105D9P serine threonine protein kinase HLG75_06555 ENOG4105EVZ LysR family transcriptional regulator HLG75_06560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLG75_06565 ENOG4105C26 Dehydrogenase HLG75_06600 ENOG4105H4F exported protein HLG75_06630 ENOG4105D6U Sodium Glutamate Symporter HLG75_06640 ENOG4105JXH GntR family transcriptional regulator HLG75_06690 ENOG4105CSH Transporter HLG75_06725 ENOG4105F1S paraquat-inducible protein a HLG75_06730 ENOG4105DY2 Paraquat-inducible protein b HLG75_06775 ENOG4105CK2 sodium dicarboxylate symporter HLG75_06785 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HLG75_06790 ENOG4108UMI ABC transporter, permease HLG75_06795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLG75_06805 ENOG4105C12 Phosphoribosylglycinamide synthetase HLG75_06810 ENOG4105DC1 bifunctional purine biosynthesis protein purh HLG75_06815 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HLG75_06865 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLG75_06870 ENOG4105CDU Replicative dna helicase HLG75_06895 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HLG75_06900 ENOG4105CCU oxidase (Subunit III) HLG75_06905 ENOG4105BZ9 Cytochrome C oxidase, subunit I HLG75_06910 ENOG4105E2S oxidase) subunit II HLG75_06935 ENOG4107BJW polysaccharide deacetylase HLG75_06940 ENOG4105CND Glycosyl transferase, family 2 HLG75_06955 ENOG4105DEN Luciferase family HLG75_06970 ENOG4105CC0 LysR family Transcriptional regulator HLG75_06985 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HLG75_07000 ENOG4105C1G acyl-Coa dehydrogenase HLG75_07010 ENOG4108MEJ flavin reductase domain protein HLG75_07015 ENOG4105D06 uba thif-type nad fad binding protein HLG75_07025 ENOG4105KRF dihydroneopterin aldolase HLG75_07035 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HLG75_07040 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HLG75_07045 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HLG75_07050 ENOG4105C08 Histidine kinase HLG75_07055 ENOG4105EEX Two component transcriptional regulator (Winged helix family HLG75_07060 ENOG4105CFQ glutamine synthetase HLG75_07075 ENOG4107S74 Lysophospholipid transporter LplT HLG75_07080 ENOG4105CFU surface antigen HLG75_07095 ENOG4107QIJ Aconitate hydratase 2 HLG75_07105 ENOG4105EYW Ion transport protein HLG75_07110 ENOG4105F27 Major Facilitator HLG75_07125 ENOG4105DZ2 Transcriptional regulator HLG75_07160 ENOG4105K8N protein family UPF0079, ATPase HLG75_07165 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HLG75_07175 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HLG75_07180 ENOG4108TZV Membrane HLG75_07185 ENOG4108RCM Nitroreductase HLG75_07205 ENOG4105CX6 glutaminyL-tRNA synthetase HLG75_07210 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HLG75_07215 ENOG4107FQ9 ethanolamine ammonia-lyase HLG75_07220 ENOG4105CPD ethanolamine ammonia-lyase HLG75_07225 ENOG4107R55 ethanolamine transporter HLG75_07235 ENOG4107RR1 TRANSCRIPTIONal HLG75_07245 ENOG4105C0A alcohol dehydrogenase HLG75_07250 ENOG4107QUV Domain protein HLG75_07275 ENOG4105CD8 aminopeptidase N HLG75_07290 ENOG4108D1K outer membrane usher protein HLG75_07315 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HLG75_07320 ENOG4105EW9 transcriptional regulator AsnC family HLG75_07330 ENOG4105R8C Transcriptional regulator HLG75_07340 ENOG4105CUY Mechanosensitive ion channel HLG75_07370 ENOG4105CNM Receptor HLG75_07390 ENOG4105C5H ABC transporter HLG75_07395 ENOG41081QV Universal stress protein HLG75_07415 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HLG75_07425 ENOG4105DKK Benzoate HLG75_07430 ENOG4105EW9 transcriptional regulator AsnC family HLG75_07435 ENOG4108NIW Leucine export protein LeuE HLG75_07445 ENOG4105C5Q Transcriptional regulator HLG75_07455 ENOG4105CHU acetyl-coa acetyltransferase HLG75_07460 ENOG4105CHR reductase HLG75_07485 ENOG4107QMP dna polymerase iii subunits gamma and tau HLG75_07490 ENOG4105HSS phospholipase C HLG75_07500 ENOG4105C0A alcohol dehydrogenase HLG75_07530 ENOG4105CBC glutamate synthase HLG75_07550 ENOG4105D8G Major Facilitator superfamily HLG75_07560 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLG75_07565 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HLG75_07590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLG75_07600 ENOG4107QZF nitrite reductase NADPH large subunit HLG75_07605 ENOG4108IFG nitrite reductase, (NAD(P)H) HLG75_07640 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HLG75_07645 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLG75_07655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLG75_07660 ENOG4105T38 integral membrane protein HLG75_07680 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HLG75_07685 ENOG4105CMR udp-glucose 4-epimerase HLG75_07740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLG75_07745 ENOG4105CUX Signal transduction histidine kinase HLG75_07770 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HLG75_07775 ENOG4105KNE Phosphatidate cytidylyltransferase HLG75_07785 ENOG4105DZP Membrane-associated zinc metalloprotease HLG75_07790 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HLG75_07810 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HLG75_07825 ENOG4105Y3E Modulates RecA activity (By similarity) HLG75_07835 ENOG4105VEJ Heat shock protein HLG75_07840 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HLG75_07865 ENOG4105F7P transcriptional regulator AsnC family HLG75_07875 ENOG4105C85 amino acid HLG75_07890 ENOG4105CHH sulfate transporter HLG75_07895 ENOG4108RAV Conserved protein HLG75_07900 ENOG4105D8V Glucose sorbosone dehydrogenase HLG75_07910 ENOG4105BZU Histidine kinase HLG75_07925 ENOG4105DM4 PTS System HLG75_07930 ENOG4105DE4 1-phosphofructokinase HLG75_07935 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HLG75_07960 ENOG4105CWM branched-chain amino acid transport system II carrier protein HLG75_07965 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLG75_07970 ENOG4105CC0 LysR family Transcriptional regulator HLG75_07980 ENOG4105M2J Glutaredoxin HLG75_07985 ENOG4105C8Y Acetylornithine aminotransferase HLG75_07990 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HLG75_08015 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HLG75_08025 ENOG41068P6 UPF0319 protein HLG75_08045 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLG75_08050 ENOG4105C4M (Ubiquinol oxidase) subunit I HLG75_08060 ENOG4105PV3 Inner membrane protein yqiJ HLG75_08075 ENOG4105E0K tonB-dependent siderophore receptor HLG75_08085 ENOG4105HDD phospholipase HLG75_08090 ENOG4105CZN Potassium uptake protein HLG75_08100 ENOG4105C7B Threonine dehydratase HLG75_08130 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HLG75_08135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLG75_08145 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HLG75_08160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLG75_08205 ENOG4107VMU Membrane HLG75_08210 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HLG75_08220 ENOG4107QP7 CoA-transferase subunit A HLG75_08225 ENOG4107QNJ CoA-transferase subunit B HLG75_08230 ENOG4105CHU acetyl-coa acetyltransferase HLG75_08235 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HLG75_08240 ENOG4105F2Z 3-oxoadipate enol-lactonase HLG75_08245 ENOG4105D2S major facilitator superfamily HLG75_08250 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HLG75_08255 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HLG75_08260 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HLG75_08265 ENOG4105FF2 Type I DHQase HLG75_08270 ENOG4106JPM 3-dehydroshikimate dehydratase HLG75_08275 ENOG4105TW1 Carbohydrate-selective porin OprB HLG75_08280 ENOG4105DZG Dehydrogenase HLG75_08290 ENOG4105MD1 YeeE YedE family protein HLG75_08305 ENOG4107HP6 Transcriptional regulator HLG75_08310 ENOG4108PTX LysR family Transcriptional regulator HLG75_08315 ENOG4105C1G acyl-Coa dehydrogenase HLG75_08340 ENOG4105DNH Major Facilitator HLG75_08350 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLG75_08370 ENOG4105FUY alpha subunit HLG75_08380 ENOG4105CHR reductase HLG75_08410 ENOG4105C26 Dehydrogenase HLG75_08420 ENOG4105F2Z 3-oxoadipate enol-lactonase HLG75_08425 ENOG4105CHU acetyl-coa acetyltransferase HLG75_08430 ENOG4107QNJ CoA-transferase subunit B HLG75_08435 ENOG4107QP7 CoA-transferase subunit A HLG75_08445 ENOG4105NN7 muconolactone delta-isomerase HLG75_08450 ENOG4105DTQ mandelate racemase muconate lactonizing HLG75_08455 ENOG4108KB2 LysR family Transcriptional regulator HLG75_08465 ENOG4107EJG GntR family transcriptional regulator HLG75_08485 ENOG4105CZJ Aldehyde dehydrogenase HLG75_08500 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLG75_08510 ENOG4105NAE bifunctional deaminase-reductase domain protein HLG75_08520 ENOG4108Z6Z Transcriptional regulator HLG75_08545 ENOG4107Z3H Transcriptional regulator, TetR family HLG75_08550 ENOG4108PTX LysR family Transcriptional regulator HLG75_08555 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HLG75_08560 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HLG75_08565 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HLG75_08575 ENOG4105CSU acyl-Coa dehydrogenase HLG75_08585 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_08675 ENOG4106P55 Transcriptional regulator HLG75_08690 ENOG4105CW7 secretion protein, HlyD family HLG75_08705 ENOG4105CZJ Aldehyde dehydrogenase HLG75_08720 ENOG4105DDW LysR family Transcriptional regulator HLG75_08725 ENOG4105EXW epimerase dehydratase HLG75_08735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLG75_08740 ENOG4105CF7 AraC family transcriptional regulator HLG75_08745 ENOG4105DQ4 alcohol dehydrogenase HLG75_08755 ENOG4105EHG Permease protein HLG75_08760 ENOG4105E0A ABC, transporter HLG75_08780 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HLG75_08855 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HLG75_08890 ENOG4105M03 Domain of unknown function (DUF955) HLG75_08940 ENOG4108R6W Transcriptional regulator, ARAC family HLG75_08945 ENOG4108821 RND type efflux pump HLG75_08955 ENOG4105E0F Histidine kinase HLG75_08960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLG75_08965 ENOG4105C1P efflux transporter, rnd family, mfp subunit HLG75_08970 ENOG4105BZS acriflavin resistance protein HLG75_08985 ENOG4105F9F transposase HLG75_08990 ENOG4105X0I Fimbrial HLG75_09210 ENOG4108IGT Dipeptidase HLG75_09245 ENOG4107T31 5'-nucleotidase HLG75_09255 ENOG4105WQI isochorismatase HLG75_09260 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HLG75_09265 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HLG75_09270 ENOG4105E0C molybdate abc transporter HLG75_09275 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HLG75_09280 ENOG4105F4R Transcriptional regulator mode HLG75_09285 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HLG75_09290 ENOG4108YS2 small subunit HLG75_09295 ENOG4105F57 Anthranilate dioxygenase reductase HLG75_09320 ENOG4105CHR reductase HLG75_09330 ENOG4105D2S major facilitator superfamily HLG75_09335 ENOG4105CF7 AraC family transcriptional regulator HLG75_09340 ENOG4105DTD Dehydrogenase HLG75_09345 ENOG4105CY2 Citrate transporter HLG75_09355 ENOG4108IND Tetr family transcriptional regulator HLG75_09375 ENOG4108M0I Transcriptional regulator HLG75_09390 ENOG4105CRW Short chain fatty acid transporter HLG75_09395 ENOG4105CHU acetyl-coa acetyltransferase HLG75_09405 ENOG4107YNJ LysR family Transcriptional regulator HLG75_09420 ENOG4108IJ0 Aspartate ammonia-lyase HLG75_09430 ENOG4105CSH Transporter HLG75_09450 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HLG75_09455 ENOG4106FTQ Taurine ABC transporter, periplasmic HLG75_09480 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HLG75_09485 ENOG4105KVH Transcriptional regulator HLG75_09490 ENOG4105UEI Transcriptional Regulator AraC Family HLG75_09505 ENOG4108VCT Sulfite exporter TauE/SafE HLG75_09515 ENOG4107S76 domain protein HLG75_09525 ENOG4105FFC UPF0187 protein HLG75_09535 ENOG4105CHR reductase HLG75_09550 ENOG4105CPP Dehydrogenase, E1 component HLG75_09555 ENOG4107R0V Pyruvate dehydrogenase HLG75_09560 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HLG75_09575 ENOG4105BZU Histidine kinase HLG75_09585 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HLG75_09590 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HLG75_09600 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HLG75_09630 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HLG75_09635 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HLG75_09650 ENOG4105C28 cystathionine HLG75_09660 ENOG4105F2W methyltransferase HLG75_09690 ENOG4105K59 histidine triad (HIT) protein HLG75_09715 ENOG4107QWP ABC-2 type transporter HLG75_09720 ENOG4107QWP ABC-2 type transporter HLG75_09725 ENOG4105CJ1 ABC, transporter HLG75_09740 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HLG75_09745 ENOG4105CNM Receptor HLG75_09765 ENOG4107TSN permease HLG75_09770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HLG75_09785 ENOG4107TB6 phosphoglycerate mutase HLG75_09790 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HLG75_09795 ENOG4108YZT Adenosylcobinamide kinase HLG75_09835 ENOG4105JSC dimethylmenaquinone methyltransferase HLG75_09845 ENOG4105DJU Siderophore biosynthesis protein HLG75_09850 ENOG4105DUU IucA IucC family protein HLG75_09855 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLG75_09870 ENOG4108Z66 YbaK ebsC protein HLG75_09885 ENOG4105C1G acyl-Coa dehydrogenase HLG75_09890 ENOG4105C1G acyl-Coa dehydrogenase HLG75_09895 ENOG4105EEF Alkane 1-monooxygenase HLG75_09900 ENOG4105E7U AraC family transcriptional regulator HLG75_09905 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HLG75_09910 ENOG4105K70 DNA-binding protein HLG75_09925 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HLG75_09935 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HLG75_09940 ENOG4108Z4V iron-sulfur cluster assembly HLG75_09955 ENOG4108ZIT Ferredoxin, 2FE-2S HLG75_09960 ENOG4105F8J Adenylate Guanylate cyclase HLG75_09970 ENOG4108JA2 transcriptioN-repair coupling factor HLG75_09990 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HLG75_09995 ENOG4105K4T epimerase HLG75_10010 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HLG75_10030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLG75_10040 ENOG4105DGW oligopeptidase A HLG75_10080 ENOG4105SG9 biopolymer transport protein, ExbD HLG75_10090 ENOG4107QP3 malate synthase g HLG75_10170 ENOG4105UPP uncharacterized protein ydcA HLG75_10350 ENOG4105CDU Replicative dna helicase HLG75_10435 ENOG4105D6Z AFG1 family ATPase HLG75_10445 ENOG4107RN6 Monooxygenase HLG75_10465 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HLG75_10470 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HLG75_10485 ENOG4108Z6B deaminase HLG75_10505 ENOG4108RTD type II secretion system protein K HLG75_10530 ENOG4105F8V Hydrolase, tatD family HLG75_10540 ENOG4107QRG dna polymerase iii HLG75_10550 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HLG75_10555 ENOG4105BZ1 (ABC) transporter HLG75_10570 ENOG4105FA0 parb-like partition protein HLG75_10575 ENOG4107QJE Chromosome Partitioning Protein HLG75_10585 ENOG4108S0S Nucleotidyl transferase HLG75_10590 ENOG4105EHM Aminoglycoside phosphotransferase HLG75_10595 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HLG75_10600 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HLG75_10605 ENOG4105D2N Aldolase HLG75_10625 ENOG4108UHJ MAF-like protein HLG75_10630 ENOG4105EZE Cupin 4 family protein HLG75_10640 ENOG41080HT Transcriptional regulator, arsr family HLG75_10650 ENOG4105XPP Protein of unknown function (DUF1275) HLG75_10655 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HLG75_10660 ENOG4105BZ1 (ABC) transporter HLG75_10670 ENOG4108ZX5 transcriptional regulator HLG75_10680 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HLG75_10685 ENOG4105CK7 Sodium proline symporter HLG75_10690 ENOG4105EW9 transcriptional regulator AsnC family HLG75_10695 ENOG4105C26 Dehydrogenase HLG75_10700 ENOG4105YGK Pfam:UPF0157 HLG75_10715 ENOG4108T58 Mg2 transport protein CorA HLG75_10725 ENOG4108YYC ycei family HLG75_10735 ENOG4105CV1 Transketolase (EC 2.2.1.1) HLG75_10760 ENOG4108HWY Beta-lactamase HLG75_10780 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HLG75_10785 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HLG75_10805 ENOG4105X0I Fimbrial HLG75_10810 ENOG4105GQR Chaperone HLG75_10835 ENOG4108IPJ Membrane HLG75_10845 ENOG4105ETS cytosine purines uracil thiamine allantoin HLG75_10855 ENOG4105CC0 LysR family Transcriptional regulator HLG75_10875 ENOG41067SE Tetr family transcriptional regulator HLG75_10890 ENOG4105EW9 transcriptional regulator AsnC family HLG75_10900 ENOG4105CDA abc transporter atp-binding protein HLG75_10905 ENOG4105DRP amino acid AbC transporter HLG75_10910 ENOG4105EAD ABC transporter HLG75_10925 ENOG4107T8P acyl-Coa dehydrogenase HLG75_10940 ENOG4105D01 (LipO)protein HLG75_10945 ENOG4105D01 (LipO)protein HLG75_10950 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLG75_10955 ENOG4108UMI ABC transporter, permease HLG75_10960 ENOG4105C3G gtp-binding protein HLG75_10985 ENOG4108UMN azlc family HLG75_10990 ENOG4105ZED uncharacterized protein ygaH HLG75_11020 ENOG4105E7U AraC family transcriptional regulator HLG75_11025 ENOG4108V06 Glutathione peroxidase HLG75_11035 ENOG4105CHM Aminotransferase HLG75_11040 ENOG4105CK2 sodium dicarboxylate symporter HLG75_11050 ENOG4105C0B DNA polymerase III (alpha subunit) HLG75_11075 ENOG4108JU3 Alkyl hydroperoxide reductase HLG75_11090 ENOG4108KB2 LysR family Transcriptional regulator HLG75_11095 ENOG4105D6J arsenicaL-resistance protein HLG75_11100 ENOG41082YX Transcriptional regulator, arsr family HLG75_11115 ENOG4105CPN adenine deaminase HLG75_11125 ENOG4105CBN LysR family transcriptional regulator HLG75_11135 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HLG75_11150 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HLG75_11155 ENOG4108IY8 ABC, transporter HLG75_11160 ENOG4106FTQ Taurine ABC transporter, periplasmic HLG75_11170 ENOG4105C54 Major Facilitator superfamily HLG75_11190 ENOG4105C4M (Ubiquinol oxidase) subunit I HLG75_11195 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLG75_11205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLG75_11210 ENOG4108K70 Transcriptional regulator HLG75_11225 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HLG75_11230 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HLG75_11245 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HLG75_11250 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HLG75_11260 ENOG4105ETT transcriptional Regulator, LysR family HLG75_11270 ENOG4105DXI Major Facilitator superfamily HLG75_11285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLG75_11290 ENOG41067MG lrgb family HLG75_11295 ENOG4105VAW lrga family HLG75_11300 ENOG4105CMU LysR family (Transcriptional regulator HLG75_11305 ENOG4108SHQ Glutathione S-transferase HLG75_11310 ENOG4105CYM Glutathione S-transferase HLG75_11315 ENOG4105CBN LysR family transcriptional regulator HLG75_11320 ENOG4105CHR reductase HLG75_11330 ENOG4105D7W serine acetyltransferase HLG75_11335 ENOG4105ESN nucleotide-binding protein HLG75_11340 ENOG4105C9B Cysteine desulfurase HLG75_11355 ENOG4105EXG Transcriptional regulator HLG75_11365 ENOG4105CT1 (ABC) transporter HLG75_11370 ENOG4107RP9 extracellular solute-binding protein, family 3 HLG75_11380 ENOG4108HW4 amino acid AbC transporter HLG75_11385 ENOG4105EAD ABC transporter HLG75_11400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HLG75_11405 ENOG4105BZU Histidine kinase HLG75_11415 ENOG4105EW9 transcriptional regulator AsnC family HLG75_11445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HLG75_11485 ENOG4105F9F transposase HLG75_11500 ENOG4105HEI LysR family (Transcriptional regulator HLG75_11520 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_11525 ENOG4105R8C Transcriptional regulator HLG75_11530 ENOG4105C1G acyl-Coa dehydrogenase HLG75_11535 ENOG4107QX3 carboxylase HLG75_11540 ENOG4105E39 Enoyl-CoA hydratase HLG75_11555 ENOG4105CC0 LysR family Transcriptional regulator HLG75_11575 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HLG75_11580 ENOG4107STF Involved in phosphonate degradation (By similarity) HLG75_11590 ENOG4107RCV ABC transporter, permease HLG75_11595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLG75_11600 ENOG4105C4Y ABC transporter HLG75_11615 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HLG75_11620 ENOG4107HP6 Transcriptional regulator HLG75_11630 ENOG4105HEI LysR family (Transcriptional regulator HLG75_11635 ENOG4105CPW cytochrome b561 HLG75_11640 ENOG4107VGR Catalase HLG75_11670 ENOG4107YAU phenylacetic acid degradation protein HLG75_11675 ENOG4108Z0R Transferase HLG75_11680 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HLG75_11685 ENOG4105DZS Phenylacetate-CoA ligase HLG75_11690 ENOG4105CHU acetyl-coa acetyltransferase HLG75_11695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HLG75_11700 ENOG4108UKI Enoyl-CoA hydratase HLG75_11705 ENOG4105E39 Enoyl-CoA hydratase HLG75_11710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HLG75_11715 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HLG75_11720 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HLG75_11725 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HLG75_11730 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HLG75_11735 ENOG4105DXM phenylacetic acid degradation protein HLG75_11740 ENOG4105EJQ L-serine dehydratase HLG75_11745 ENOG4107QTZ amino acid HLG75_11750 ENOG4105CZJ Aldehyde dehydrogenase HLG75_11775 ENOG4105MWK D-amino acid dehydrogenase, small subunit HLG75_11795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLG75_11805 ENOG4108Z4X TRANSCRIPTIONal HLG75_11815 ENOG4105WPN DNA integration recombination invertion protein HLG75_11830 ENOG4105DJ2 Major Facilitator Superfamily HLG75_11835 ENOG4107Y2X deaminase HLG75_11845 ENOG4105EMY transcriptional regulator HLG75_11875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLG75_11940 ENOG4105E6M Sulphatase-modifying factor protein HLG75_11970 ENOG4108HW3 (ABC) transporter HLG75_11980 ENOG4105MRR Transcriptional regulator (By similarity) HLG75_12005 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HLG75_12010 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLG75_12025 ENOG4105E2A Dehydrogenase HLG75_12035 ENOG4105R8C Transcriptional regulator HLG75_12040 ENOG4105F9F transposase HLG75_12050 ENOG4107R4J Chloride channel HLG75_12055 ENOG4108JIK carboxylase HLG75_12075 ENOG4105C5A transporter HLG75_12080 ENOG4108WAV Transcriptional regulator HLG75_12115 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HLG75_12135 ENOG4105D2S major facilitator superfamily HLG75_12150 ENOG4105D7N magnesium and cobalt transport protein CorA HLG75_12155 ENOG4105D1S lipid A biosynthesis HLG75_12160 ENOG4105BZU Histidine kinase HLG75_12185 ENOG4108Z4U Ferredoxin HLG75_12225 ENOG4105DFG type I secretion outer membrane protein HLG75_12235 ENOG4108IUZ ABC transporter HLG75_12240 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HLG75_12255 ENOG4105C2X Arabinose 5-phosphate isomerase HLG75_12320 ENOG4105II7 pyrroline-5-carboxylate reductase HLG75_12330 ENOG4105VEQ Cold shock protein HLG75_12335 ENOG410829K Lysine exporter protein (Lyse ygga) HLG75_12370 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HLG75_12420 ENOG4108KB2 LysR family Transcriptional regulator HLG75_12425 ENOG4105FUY alpha subunit HLG75_12430 ENOG4108UKV benzoate 1,2-dioxygenase HLG75_12435 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HLG75_12440 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase HLG75_12445 ENOG4105DKK Benzoate HLG75_12450 ENOG4105D2S major facilitator superfamily HLG75_12465 ENOG4105CQ7 ATP-dependent helicase HLG75_12470 ENOG4105D3R alkyl hydroperoxide reductase HLG75_12480 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HLG75_12490 ENOG4108JU3 Alkyl hydroperoxide reductase HLG75_12500 ENOG4108K3A Glutathione S-transferase HLG75_12510 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HLG75_12515 ENOG4108TGY Glutathione S-transferase HLG75_12525 ENOG4108ZG0 Ompa motb domain protein HLG75_12530 ENOG4105CD3 dihydroorotase HLG75_12560 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLG75_12575 ENOG4108UKZ OsmC family HLG75_12580 ENOG4107RYR Transcriptional regulator, Crp Fnr family HLG75_12585 ENOG4105CPC Aldo Keto reductase HLG75_12600 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HLG75_12610 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HLG75_12735 ENOG41090AG Bacteriophage protein HLG75_12745 ENOG4105F9F transposase HLG75_12755 ENOG4107ZQ5 Phage-associated protein, HI1409 family HLG75_12865 ENOG4105W7J DNA binding HLG75_12870 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HLG75_12925 ENOG4105CFH Aspartokinase HLG75_12935 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HLG75_12945 ENOG4105CPW cytochrome b561 HLG75_12950 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HLG75_12955 ENOG4105C7N Xanthine uracil vitamin C permease HLG75_12965 ENOG4105F95 Monooxygenase HLG75_13000 ENOG4105F95 Monooxygenase HLG75_13005 ENOG4105JQZ Methyltransferase HLG75_13015 ENOG4107RN6 Monooxygenase HLG75_13035 ENOG4105EPF Outer membrane porin HLG75_13040 ENOG4105D2S major facilitator superfamily HLG75_13050 ENOG4105E3J oxidoreductase HLG75_13065 ENOG4108SC4 )-transporter HLG75_13070 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HLG75_13085 ENOG4105C1G acyl-Coa dehydrogenase HLG75_13090 ENOG4105EPF Outer membrane porin HLG75_13095 ENOG4105NI3 Protein of unknown function (DUF3237) HLG75_13110 ENOG4105JXH GntR family transcriptional regulator HLG75_13115 ENOG4105CZJ Aldehyde dehydrogenase HLG75_13125 ENOG4105EQX glucarate dehydratase HLG75_13130 ENOG4105DJB Major Facilitator Superfamily HLG75_13135 ENOG4105CTX dehydratase HLG75_13140 ENOG4105DJP Membrane HLG75_13145 ENOG4108ZX5 transcriptional regulator HLG75_13150 ENOG4107RGH Aldehyde dehydrogenase HLG75_13170 ENOG4105C85 amino acid HLG75_13190 ENOG4105C26 Dehydrogenase HLG75_13220 ENOG4105C85 amino acid HLG75_13250 ENOG4105D01 (LipO)protein HLG75_13270 ENOG4105CR8 Transcriptional regulator HLG75_13275 ENOG4105MWK D-amino acid dehydrogenase, small subunit HLG75_13280 ENOG4105M4H endoribonuclease L-psp HLG75_13300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLG75_13325 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HLG75_13345 ENOG4108JQ5 ABC transporter HLG75_13350 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HLG75_13355 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HLG75_13365 ENOG4105E9H Lytic Murein transglycosylase HLG75_13365 ENOG4105E9H Lytic Murein transglycosylase HLG75_13370 ENOG4107RZZ dna polymerase iii epsilon subunit HLG75_13380 ENOG4105E09 nadh pyrophosphatase HLG75_13390 ENOG4105W4M Transport-associated protein HLG75_13400 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HLG75_13410 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HLG75_13415 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HLG75_13435 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HLG75_13440 ENOG4105D0A hydroxylase HLG75_13445 ENOG4107RAQ aminopeptidase HLG75_13475 ENOG4105DIJ Phosphoethanolamine transferase HLG75_13525 ENOG4105DR5 peptidase HLG75_13825 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HLG75_13855 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HLG75_13865 ENOG4105D82 Glutamate dehydrogenase HLG75_13870 ENOG4108R3D Electron transport complex HLG75_13875 ENOG4105CSM endonuclease III HLG75_13900 ENOG4105CJN penicillin-binding protein HLG75_13905 ENOG4106H78 methyltransferase HLG75_13920 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HLG75_13930 ENOG4105CQM Urea amidohydrolase subunit alpha HLG75_13965 ENOG4107RET Isocitrate lyase HLG75_13975 ENOG4105C37 (CBS) domain HLG75_13980 ENOG4105D4T Citrate transporter HLG75_13995 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HLG75_14010 ENOG4108MRJ HLG75_14030 ENOG4105VCQ rubredoxin HLG75_14035 ENOG4107QZF nitrite reductase NADPH large subunit HLG75_14045 ENOG4105C5Q Transcriptional regulator HLG75_14070 ENOG4107U91 Rhomboid family HLG75_14075 ENOG4105CV6 ABC transporter, permease HLG75_14080 ENOG4108I0Y (ABC) transporter HLG75_14085 ENOG4108UJV acyl-CoA thioesterase i HLG75_14105 ENOG4107RNH Outer membrane receptor FepA HLG75_14120 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HLG75_14125 ENOG4105E6M Sulphatase-modifying factor protein HLG75_14145 ENOG4105CJ3 phosphate transporter HLG75_14150 ENOG4105C3R Methionine synthase HLG75_14165 ENOG4105CSP Major Facilitator Superfamily HLG75_14175 ENOG4108PZW LysR family Transcriptional regulator HLG75_14185 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HLG75_14195 ENOG4105EU0 Major facilitator Superfamily HLG75_14200 ENOG4108R6W Transcriptional regulator, ARAC family HLG75_14205 ENOG4105CSV Glutaminase HLG75_14210 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HLG75_14215 ENOG4105CSH Transporter HLG75_14225 ENOG4105C7K acetolactate synthase HLG75_14240 ENOG4105CHR reductase HLG75_14245 ENOG4108MXF Alpha Beta Hydrolase HLG75_14255 ENOG4105DJB Major Facilitator Superfamily HLG75_14260 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HLG75_14270 ENOG4105CHR reductase HLG75_14290 ENOG41069M3 Transcriptional regulator HLG75_14305 ENOG4106YT9 Enoyl-CoA hydratase HLG75_14315 ENOG4105CND Glycosyl transferase, family 2 HLG75_14320 ENOG4107BJW polysaccharide deacetylase HLG75_14330 ENOG4108VWS Yaeq family HLG75_14340 ENOG4105CKI cobalamin synthesis protein HLG75_14350 ENOG4108S4H thioesterase Superfamily protein HLG75_14360 ENOG4105C94 Transporter HLG75_14365 ENOG4105C94 Transporter HLG75_14370 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HLG75_14395 ENOG4107QK5 Homocysteine s-methyltransferase HLG75_14400 ENOG4105D5Q Arginine ornithine antiporter HLG75_14425 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLG75_14430 ENOG4105C54 Major Facilitator superfamily HLG75_14485 ENOG4108UUM single-stranded DNA-binding protein HLG75_14530 ENOG4105DFP Integrase HLG75_14540 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HLG75_14545 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLG75_14550 ENOG4105CW7 secretion protein, HlyD family HLG75_14555 ENOG4108VUY thioesterase Superfamily protein HLG75_14560 ENOG4105D52 delta-aminolevulinic acid dehydratase HLG75_14565 ENOG4105MWK D-amino acid dehydrogenase, small subunit HLG75_14570 ENOG4105ECP epimerase HLG75_14590 ENOG4107RH8 nuclease SbcCD subunit D HLG75_14595 ENOG4105EYH Exonuclease HLG75_14600 ENOG4105DFA alanine racemase domain protein HLG75_14605 ENOG4105CZX twitching motility protein HLG75_14610 ENOG4105CZX twitching motility protein HLG75_14615 ENOG41090R7 Ferric uptake HLG75_14625 ENOG4105VDB UPF0125 protein HLG75_14640 ENOG4105E7A Glutamine amidotransferase HLG75_14655 ENOG4107QKV phosphomannomutase HLG75_14665 ENOG4105C4R Atp-dependent dna helicase HLG75_14670 ENOG4108ZG0 Ompa motb domain protein HLG75_14675 ENOG4106HNH Acyl-transferase HLG75_14690 ENOG4107QMS site-determining protein HLG75_14705 ENOG4105CCF Lysine exporter protein (Lyse ygga) HLG75_14710 ENOG4105CNU cell division protein FtsK HLG75_14715 ENOG4105C3M thioredoxin reductase HLG75_14720 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HLG75_14730 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HLG75_14775 ENOG4108YXA Membrane HLG75_14780 ENOG4105EUB pirin domain protein HLG75_14790 ENOG4105C4K Nad synthetase HLG75_14805 ENOG4105E3J oxidoreductase HLG75_14810 ENOG4105C26 Dehydrogenase HLG75_14815 ENOG4105DVW rieske (2Fe-2S) HLG75_14825 ENOG4105C94 Transporter HLG75_14830 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HLG75_14835 ENOG4105EJC lysr family transcriptional regulator HLG75_14855 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HLG75_14875 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HLG75_14880 ENOG4105C34 Pseudouridine synthase HLG75_14885 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HLG75_14890 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HLG75_14905 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HLG75_14935 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HLG75_14965 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HLG75_14975 ENOG4105DWF phosphomethylpyrimidine kinase HLG75_14980 ENOG4109066 lysm domain bon superfamily protein HLG75_14990 ENOG4105CHR reductase HLG75_14995 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HLG75_15005 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HLG75_15010 ENOG4108BPE -transporting atpase HLG75_15015 ENOG4107RTD sua5 ycio yrdc ywlc family protein HLG75_15020 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HLG75_15025 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HLG75_15030 ENOG4105FE9 pseudouridine synthase HLG75_15040 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLG75_15045 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HLG75_15055 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLG75_15060 ENOG4108K4C ec 3.1.3.12 HLG75_15065 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HLG75_15070 ENOG4106UW1 Major Facilitator superfamily HLG75_15090 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HLG75_15100 ENOG4105HF0 Membrane HLG75_15115 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HLG75_15125 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HLG75_15175 ENOG4105D1F ATP-binding protein HLG75_15185 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HLG75_15215 ENOG4105K6H D-cysteine desulfhydrase HLG75_15220 ENOG4105CBX hi0933 family HLG75_15245 ENOG4105DP0 ferredoxin-NADP reductase HLG75_15250 ENOG4105DUM transcriptional regulator, lysR family HLG75_15275 ENOG4105C8S subunit m HLG75_15280 ENOG4105D65 subunit l HLG75_15290 ENOG4107UFS subunit j HLG75_15305 ENOG4108IEH NADH dehydrogenase subunit g HLG75_15310 ENOG4107QIZ NADH dehydrogenase HLG75_15315 ENOG4105GKE subunit e HLG75_15335 ENOG4105BZU Histidine kinase HLG75_15345 ENOG4105E0F Histidine kinase HLG75_15350 ENOG4107EXC regulatoR HLG75_15355 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLG75_15365 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLG75_15410 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HLG75_15425 ENOG4105ETT transcriptional Regulator, LysR family HLG75_15445 ENOG4105CH2 amidohydrolase HLG75_15455 ENOG4106P55 Transcriptional regulator HLG75_15470 ENOG4106P55 Transcriptional regulator HLG75_15475 ENOG4107EFR Flavocytochrome c HLG75_15485 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HLG75_15490 ENOG4107RGD Major Facilitator superfamily HLG75_15495 ENOG4105C1G acyl-Coa dehydrogenase HLG75_15500 ENOG4105ETT transcriptional Regulator, LysR family HLG75_15535 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HLG75_15540 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HLG75_15545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLG75_15565 ENOG4105E3B Multicopper oxidase HLG75_15575 ENOG4108HCJ Hydrolase HLG75_15580 ENOG4105DJV ribulose-phosphate 3-epimerase HLG75_15605 ENOG41072GX Peptidase M22 Glycoprotease HLG75_15610 ENOG4108Z0R Transferase HLG75_15645 ENOG4105F9F transposase HLG75_15655 ENOG4105D5G Transposase HLG75_15660 ENOG4105CRQ synthase (Component I) HLG75_15670 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HLG75_15675 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HLG75_15680 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HLG75_15750 ENOG4105K56 Transcriptional regulator HLG75_15755 ENOG4108ZHJ Organic hydroperoxide resistance protein HLG75_15760 ENOG4107QHF type ii secretion system protein e HLG75_15780 ENOG4105C2M dna polymerase I HLG75_15785 ENOG4108VIA integral membrane protein HLG75_15790 ENOG4105II7 pyrroline-5-carboxylate reductase HLG75_15795 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HLG75_15805 ENOG4105C9X ppx gppa phosphatase HLG75_15815 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HLG75_15835 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HLG75_15875 ENOG4105W39 Membrane HLG75_15880 ENOG4105CYM Glutathione S-transferase HLG75_15895 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_15900 ENOG4105N42 UPF0307 protein HLG75_15905 ENOG41080Z8 PHOSPHOCARRIER protein HLG75_15925 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HLG75_15930 ENOG4105DJ0 Poly(A) Polymerase HLG75_15935 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HLG75_15940 ENOG4105DXN mazG family HLG75_15950 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HLG75_15965 ENOG4105C6T cysteine synthase HLG75_15970 ENOG4105BZU Histidine kinase HLG75_15975 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HLG75_15980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLG75_15985 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HLG75_16000 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HLG75_16005 ENOG4105W8H transhydrogenase (subunit alpha HLG75_16010 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HLG75_16015 ENOG4106UX7 integral membrane protein HLG75_16030 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HLG75_16040 ENOG4107RSM transcriptional regulator HLG75_16050 ENOG4105CUZ uba thif-type nad fad binding protein HLG75_16055 ENOG4107QM5 aconitate hydratase HLG75_16060 ENOG4105F8V Hydrolase, tatD family HLG75_16075 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HLG75_16115 ENOG4105BZU Histidine kinase HLG75_16125 ENOG4108ZP8 Acetolactate synthase small subunit HLG75_16130 ENOG4105C7K acetolactate synthase HLG75_16155 ENOG4105DJY efflux transporter, rnd family, mfp subunit HLG75_16160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HLG75_16165 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HLG75_16170 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HLG75_16180 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HLG75_16185 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HLG75_16195 ENOG4105VW4 glutaredoxin 3 HLG75_16215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLG75_16220 ENOG4105C2D reductase HLG75_16230 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLG75_16260 ENOG4105C84 Histidine ammonia-lyase HLG75_16270 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HLG75_16275 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_16290 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HLG75_16310 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HLG75_16330 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HLG75_16350 ENOG4105WVQ Fe-S assembly protein IscX HLG75_16365 ENOG4105CN1 protease HLG75_16380 ENOG4106HB6 Alpha beta hydrolase HLG75_16390 ENOG4105C26 Dehydrogenase HLG75_16395 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HLG75_16400 ENOG4105C6Z Gluconate HLG75_16405 ENOG4108UHU Aldolase HLG75_16410 ENOG4105C01 Dihydroxy-acid dehydratase HLG75_16415 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HLG75_16420 ENOG4108DNC Involved in acetate metabolism (By similarity) HLG75_16425 ENOG4107GFK fumarate HLG75_16445 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HLG75_16455 ENOG4108ESX Receptor HLG75_16465 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HLG75_16475 ENOG4105DWV Homoserine O-trans-acetylase HLG75_16620 ENOG4105CIY formyltetrahydrofolate deformylase HLG75_16630 ENOG4107RGH Aldehyde dehydrogenase HLG75_16645 ENOG4105CKD glutathione-regulated potassium-efflux system protein HLG75_16665 ENOG4105VFU Rna-binding protein HLG75_16670 ENOG4105C4R Atp-dependent dna helicase HLG75_16685 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HLG75_16695 ENOG4105KVH Transcriptional regulator HLG75_16710 ENOG4105C5H ABC transporter HLG75_16715 ENOG4105N14 lysine exporter protein LysE YggA HLG75_16720 ENOG4105D1S lipid A biosynthesis HLG75_16730 ENOG4105CK2 sodium dicarboxylate symporter HLG75_16785 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HLG75_16810 ENOG4105DUM transcriptional regulator, lysR family HLG75_16825 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HLG75_16840 ENOG4108W5M transcriptional regulator HLG75_16855 ENOG4105D29 Helix-turn-helix type 11 domain protein HLG75_16860 ENOG4107XGZ Hydrolase HLG75_16865 ENOG4105EI2 Pseudouridine synthase HLG75_16875 ENOG4105C03 ribonuclease HLG75_16880 ENOG4105J5T Amp-dependent synthetase and ligase HLG75_16895 ENOG4105CBN LysR family transcriptional regulator HLG75_16905 ENOG4105CSA Coproporphyrinogen iii oxidase HLG75_16915 ENOG4107QI1 Mate efflux family protein HLG75_16925 ENOG4107T8P acyl-Coa dehydrogenase HLG75_16955 ENOG4105BZ8 glutamate synthase HLG75_16965 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HLG75_16970 ENOG4105C5X domain protein HLG75_16985 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HLG75_16995 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HLG75_17005 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HLG75_17010 ENOG4108JU5 Magnesium and cobalt efflux protein HLG75_17015 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HLG75_17020 ENOG4108Z7R Chaperone CsaA HLG75_17030 ENOG4108VAU general secretion pathway protein G HLG75_17035 ENOG4105D7Q type ii secretion system HLG75_17040 ENOG4105C25 Primosomal protein n' HLG75_17045 ENOG4105CKD glutathione-regulated potassium-efflux system protein HLG75_17060 ENOG4105DVC DnaJ domain protein HLG75_17065 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HLG75_17070 ENOG4107QUT magnesium and cobalt transport protein CorA HLG75_17090 ENOG4107QYX exodeoxyribonuclease v alpha HLG75_17095 ENOG4107QKA exodeoxyribonuclease V beta HLG75_17100 ENOG4105DSY exodeoxyribonuclease V, gamma HLG75_17110 ENOG4105CSR polyphosphate kinase 2 HLG75_17120 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HLG75_17135 ENOG41061H0 Monooxygenase HLG75_17140 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HLG75_17155 ENOG4105D65 subunit l HLG75_17160 ENOG4108ZE9 Monovalent cation H antiporter subunit C HLG75_17165 ENOG4107R4Z monovalent cation h antiporter subunit d HLG75_17170 ENOG4105SC1 monovalent cation H antiporter subunit E HLG75_17175 ENOG4105W4C monovalent cation H antiporter subunit F HLG75_17180 ENOG4105KJM monovalent cation h antiporter subunit g HLG75_17195 ENOG4105CHV Transcription elongation factor NusA HLG75_17220 ENOG4107EJC Preprotein translocase subunit SecG HLG75_17230 ENOG4107QHF type ii secretion system protein e HLG75_17245 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HLG75_17255 ENOG4105C2N RNA methyltransferase TrmH family group 3 HLG75_17270 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HLG75_17280 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HLG75_17310 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLG75_17315 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HLG75_17375 ENOG4107ZXU DSBA oxidoreductase HLG75_17390 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HLG75_17405 ENOG4105D3Y Na H antiporter HLG75_17410 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HLG75_17460 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HLG75_17465 ENOG4105PM1 preprotein translocase subunit SecE HLG75_17505 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HLG75_17510 ENOG4105TV9 FHA Domain-Containing protein HLG75_17515 ENOG4105GVR general secretion pathway protein D HLG75_17530 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HLG75_17555 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HLG75_17560 ENOG4108NEV two component transcriptional regulator, LytTR family HLG75_17565 ENOG4108HRK Histidine kinase HLG75_17580 ENOG4108UTW Plays a role in the regulation of phosphate uptake HLG75_17585 ENOG4105DFG type I secretion outer membrane protein HLG75_17590 ENOG4108RNG Permease of the drug metabolite transporter HLG75_17615 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HLG75_17625 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HLG75_17630 ENOG4105CNI cell division protein FtsW HLG75_17645 ENOG4105CE1 Ferrous iron transport protein b HLG75_17655 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLG75_17660 ENOG4105T95 Thiol disulfide interChange protein HLG75_17665 ENOG4105D6E homoserine dehydrogenase HLG75_17675 ENOG41061WM D-Alanyl-D-Alanine HLG75_17685 ENOG4107TUY Histidine kinase HLG75_17690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLG75_17695 ENOG4105CN1 protease HLG75_17700 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HLG75_17705 ENOG4108K5H permease YjgP YjgQ family protein HLG75_17745 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HLG75_17755 ENOG4105BZU Histidine kinase HLG75_17770 ENOG4105C0P Mg chelatase subunit ChlI HLG75_17775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLG75_17785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLG75_17795 ENOG41090KI Outer membrane porin HLG75_17800 ENOG4105F0N pyrophosphate phospho-hydrolase HLG75_17815 ENOG4105CEY Amp-dependent synthetase and ligase HLG75_17820 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLG75_17825 ENOG41079KZ Major Facilitator Superfamily HLG75_17830 ENOG4105EN6 Membrane HLG75_17835 ENOG4105K5B UPF0225 protein HLG75_17840 ENOG4105EE5 Membrane protein terC HLG75_17845 ENOG4108URH decarboxylase HLG75_17850 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLG75_17860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HLG75_17875 ENOG4105CCT upf0313 protein HLG75_17895 ENOG4105CS1 NAD(P)H quinone oxidoreductase HLG75_17905 ENOG4105C6T cysteine synthase HLG75_17940 ENOG4105Y7M Transcriptional regulator, TetR family HLG75_17975 ENOG4105C79 DNA protecting protein DprA HLG75_17990 ENOG4108IND Tetr family transcriptional regulator HLG75_17995 ENOG4107RTG Major Facilitator superfamily HLG75_18005 ENOG4108V06 Glutathione peroxidase HLG75_18015 ENOG41090VV Protein of unknown function (DUF2846) HLG75_18075 ENOG4105FDK ABC transporter HLG75_18080 ENOG4105FAV ABC, transporter HLG75_18085 ENOG410829K Lysine exporter protein (Lyse ygga) HLG75_18090 ENOG4105EZR dyp-type peroxidase family protein HLG75_18095 ENOG4107R1I NAD-dependent malic enzyme HLG75_18120 ENOG4105EUB pirin domain protein HLG75_18140 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HLG75_18145 ENOG4106MP8 UPF0754 membrane protein HLG75_18150 ENOG4108VBZ doxx family HLG75_18155 ENOG4105DQR SNARE associated Golgi HLG75_18170 ENOG4107QJE Chromosome Partitioning Protein HLG75_18180 ENOG4107PSF BolA-like protein HLG75_18225 ENOG4105C1G acyl-Coa dehydrogenase HLG75_18230 ENOG4107RCI amp-dependent synthetase and ligase HLG75_18250 ENOG4105CSH Transporter HLG75_18255 ENOG4105E39 Enoyl-CoA hydratase HLG75_18260 ENOG4105E39 Enoyl-CoA hydratase HLG75_18265 ENOG4105C1G acyl-Coa dehydrogenase HLG75_18275 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLG75_18280 ENOG4105C26 Dehydrogenase HLG75_18290 ENOG4105C85 amino acid HLG75_18295 ENOG4105C85 amino acid HLG75_18300 ENOG4105M4H endoribonuclease L-psp HLG75_18315 ENOG4105EW9 transcriptional regulator AsnC family HLG75_18340 ENOG4105D3G Pseudouridine synthase HLG75_18420 ENOG4108I0Z Aconitate hydratase HLG75_18425 ENOG4105BZN citrate synthase HLG75_18430 ENOG4105CR4 methylisocitrate lyase HLG75_18435 ENOG4105DRR Transcriptional regulator, GntR family HLG75_18445 ENOG4105CGF Aromatic amino acid aminotransferase HLG75_18450 ENOG4105CXG d-lactate dehydrogenase HLG75_18460 ENOG41073TP transcriptional regulator HLG75_18465 ENOG4105DAA L-lactate HLG75_18470 ENOG4107QKV phosphomannomutase HLG75_18475 ENOG4105CMR udp-glucose 4-epimerase HLG75_18485 ENOG4105C6Y Udp-glucose 6-dehydrogenase HLG75_18490 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLG75_18495 ENOG4105D3Q Sugar transferase HLG75_18500 ENOG4108RYC glycosyltransferase HLG75_18505 ENOG4105CG5 Glycosyl transferase (Group 1 HLG75_18520 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HLG75_18525 ENOG4108UW5 maltose o-acetyltransferase HLG75_18535 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HLG75_18540 ENOG4105J5G Transferase hexapeptide repeat containing protein HLG75_18545 ENOG4107R5Z Oxidoreductase domain protein HLG75_18550 ENOG4107QQG Dehydrogenase HLG75_18555 ENOG4105DAY polysaccharide export protein HLG75_18565 ENOG4105D75 Capsular exopolysaccharide family HLG75_18570 ENOG4108V1T peptidylprolyl cis-trans isomerase HLG75_18575 ENOG4108V1T peptidylprolyl cis-trans isomerase HLG75_18580 ENOG4105CJR Integral membrane protein (MviN HLG75_18585 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HLG75_18590 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HLG75_18600 ENOG4105HSS phospholipase C HLG75_18630 ENOG41062JF Transcriptional regulator HLG75_18635 ENOG4108Z33 Thiol disulfide Interchange Protein HLG75_18645 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HLG75_18650 ENOG4105UBK short-chain dehydrogenase reductase HLG75_18665 ENOG4107QZM n-acetylglutamate synthase HLG75_18670 ENOG4105GVF (ABC) transporter HLG75_18675 ENOG4105GVF (ABC) transporter HLG75_18680 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HLG75_18685 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HLG75_18690 ENOG4108VM9 ABC, transporter HLG75_18695 ENOG4108R86 Transcriptional regulator HLG75_18700 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HLG75_18710 ENOG4105DTN riboflavin biosynthesis protein ribF HLG75_18715 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HLG75_18725 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HLG75_18765 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HLG75_18820 ENOG4105CVE Lytic murein transglycosylase HLG75_18825 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HLG75_18830 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HLG75_18840 ENOG4105DFU Cell wall formation (By similarity) HLG75_18850 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HLG75_18855 ENOG4105DU1 integral membrane protein, terc HLG75_18865 ENOG4106032 Glutathionylspermidine synthase HLG75_18875 ENOG4107QUY Guanine deaminase HLG75_18880 ENOG4108UGV hypoxanthine phosphoribosyltransferase HLG75_18890 ENOG4105T95 Thiol disulfide interChange protein HLG75_18895 ENOG4105PGM cation diffusion facilitator family transporter HLG75_18910 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLG75_18930 ENOG4108BUD transposase HLG75_18945 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HLG75_19000 ENOG4108BUD transposase HLG75_19005 ENOG4108BUD transposase HLG75_19040 ENOG4108BUD transposase HLG75_19070 ENOG4105E4C Lytic transglycosylase catalytic HLG75_19085 ENOG4105E4C Lytic transglycosylase catalytic HLG75_19115 ENOG4105K56 Transcriptional regulator HLG75_19120 ENOG4108ZHJ Organic hydroperoxide resistance protein HLG75_19125 ENOG4105XMH SpoVT AbrB domain protein HLG75_19130 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HLG75_19135 ENOG4105E5Q amino acid AbC transporter HLG75_19155 ENOG4108BUD transposase HLG75_19190 ENOG4107QJE Chromosome Partitioning Protein