locus-tag	class	description
HLG75_00010	COG0592	DNA-directed DNA polymerase activity
HLG75_00020	COG0187	DNA topoisomerase II activity
HLG75_00030	COG0586	Pfam SNARE associated Golgi protein
HLG75_00035	COG0488	(ABC) transporter
HLG75_00060	COG0596	Alpha beta hydrolase
HLG75_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HLG75_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLG75_00110	COG0733	neurotransmitter:sodium symporter activity
HLG75_00150	COG2233	PERMEase
HLG75_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG75_00200	COG2814	Major facilitator Superfamily
HLG75_00205	COG0656	L-ascorbic acid biosynthetic process
HLG75_00210	COG0583	DNA-binding transcription factor activity
HLG75_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG75_00230	COG1064	alcohol dehydrogenase
HLG75_00235	COG2818	Glycosylase
HLG75_00250	COG1194	a g-specific adenine glycosylase
HLG75_00270	COG2983	Belongs to the UPF0260 family
HLG75_00275	COG2133	pyrroloquinoline quinone binding
HLG75_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLG75_00285	COG2116	formate transmembrane transporter activity
HLG75_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG75_00310	COG1335	isochorismatase
HLG75_00315	COG0385	Bile acid
HLG75_00320	COG0534	Mate efflux family protein
HLG75_00325	COG1683	Conserved Protein
HLG75_00345	COG0625	glutathione transferase activity
HLG75_00355	COG1113	amino acid transport
HLG75_00365	COG0523	cobalamin synthesis protein
HLG75_00375	COG2188	Transcriptional regulator
HLG75_00405	COG0010	Belongs to the arginase family
HLG75_00425	COG1280	lysine exporter protein (LysE YggA)
HLG75_00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLG75_00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLG75_00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HLG75_00500	COG0753	catalase activity
HLG75_00550	COG0534	Mate efflux family protein
HLG75_00555	COG0436	Aminotransferase
HLG75_00560	COG2733	membrane
HLG75_00575	COG2918	glutathione biosynthetic process
HLG75_00585	COG3501	Rhs element vgr protein
HLG75_00590	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLG75_00590	COG1388	LysM domain
HLG75_00610	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_00630	COG0673	inositol 2-dehydrogenase activity
HLG75_00635	COG1324	tolerance protein
HLG75_00660	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_00685	COG3150	esterase
HLG75_00695	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HLG75_00705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG75_00715	COG2233	PERMEase
HLG75_00720	COG2351	hydroxyisourate hydrolase activity
HLG75_00755	COG3706	GGDEF domain
HLG75_00770	COG1393	Belongs to the ArsC family
HLG75_00775	COG0708	Exodeoxyribonuclease III
HLG75_00800	COG0189	ligase activity
HLG75_00820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLG75_00830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLG75_00845	COG4942	peptidase
HLG75_00855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG75_00865	COG2119	membrane
HLG75_00875	COG0426	domain, Protein
HLG75_00875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG75_00900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLG75_00920	COG1902	pentaerythritol trinitrate reductase activity
HLG75_00925	COG1519	Transferase
HLG75_00935	COG0668	transmembrane transport
HLG75_00945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG75_00950	COG1335	isochorismatase
HLG75_00955	COG1522	sequence-specific DNA binding
HLG75_00980	COG2198	Histidine kinase
HLG75_00980	COG2205	protein histidine kinase activity
HLG75_00980	COG0784	Response regulator, receiver
HLG75_00985	COG3162	membrane
HLG75_00990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG75_01000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG75_01010	COG3706	GGDEF domain
HLG75_01015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLG75_01020	COG1309	transcriptional regulator
HLG75_01040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG75_01040	COG0352	thiamine-phosphate diphosphorylase activity
HLG75_01040	COG0351	phosphomethylpyrimidine kinase
HLG75_01050	COG2814	Major facilitator Superfamily
HLG75_01065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLG75_01075	COG1113	amino acid transport
HLG75_01085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLG75_01090	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_01100	COG1335	isochorismatase
HLG75_01140	COG2814	Major facilitator Superfamily
HLG75_01145	COG0583	DNA-binding transcription factor activity
HLG75_01165	COG0667	Aldo Keto reductase
HLG75_01190	COG1733	regulation of RNA biosynthetic process
HLG75_01220	COG1733	regulation of RNA biosynthetic process
HLG75_01225	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG75_01245	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HLG75_01250	COG2207	Transcriptional regulator
HLG75_01305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLG75_01320	COG2329	Antibiotic biosynthesis monooxygenase
HLG75_01350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLG75_01380	COG0427	acetyl-CoA hydrolase
HLG75_01395	COG0745	RESPONSE REGULATOR receiver
HLG75_01405	COG0659	secondary active sulfate transmembrane transporter activity
HLG75_01410	COG4221	oxidoreductase activity
HLG75_01435	COG0488	(ABC) transporter
HLG75_01500	COG0833	amino acid
HLG75_01545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLG75_01550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLG75_01565	COG2226	methyltransferase
HLG75_01615	COG0069	glutamate synthase activity
HLG75_01615	COG0070	glutamate synthase
HLG75_01615	COG0067	glutamate synthase
HLG75_01620	COG0493	'glutamate synthase
HLG75_01630	COG1704	LemA family
HLG75_01635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLG75_01645	COG4969	Belongs to the N-Me-Phe pilin family
HLG75_01650	COG3307	-O-antigen
HLG75_01670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG75_01685	COG0194	GDP metabolic process
HLG75_01735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLG75_01755	COG5380	lipid catabolic process
HLG75_01760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLG75_01785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLG75_01790	COG0277	FAD linked oxidase domain protein
HLG75_01800	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HLG75_01805	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG75_01830	COG0628	permease
HLG75_01835	COG1192	Involved in chromosome partitioning
HLG75_01865	COG0833	amino acid
HLG75_01870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG75_01875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG75_01885	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_01925	COG0583	DNA-binding transcription factor activity
HLG75_01975	COG0517	IMP dehydrogenase activity
HLG75_01980	COG1983	PspC domain protein
HLG75_01990	COG1960	acyl-CoA dehydrogenase activity
HLG75_02005	COG0408	coproporphyrinogen oxidase activity
HLG75_02025	COG0513	Belongs to the DEAD box helicase family
HLG75_02035	COG1127	ABC transporter
HLG75_02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLG75_02050	COG2854	intermembrane phospholipid transfer
HLG75_02060	COG0598	Magnesium transport protein CorA
HLG75_02070	COG0494	nUDIX hydrolase
HLG75_02075	COG1040	competence protein
HLG75_02080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLG75_02100	COG1946	Acyl-CoA thioesterase
HLG75_02105	COG1301	dicarboxylic acid transport
HLG75_02120	COG1959	2 iron, 2 sulfur cluster binding
HLG75_02125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG75_02125	COG1017	nitric oxide dioxygenase activity
HLG75_02135	COG0433	COG0433 Predicted ATPase
HLG75_02140	COG0626	cystathionine gamma-synthase activity
HLG75_02295	COG1960	acyl-CoA dehydrogenase activity
HLG75_02300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLG75_02330	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HLG75_02335	COG0339	signal peptide processing
HLG75_02340	COG0557	exoribonuclease II activity
HLG75_02385	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLG75_02390	COG2169	Transcriptional regulator
HLG75_02395	COG0697	spore germination
HLG75_02400	COG1295	ribonuclease BN
HLG75_02435	COG1702	phosphate starvation-inducible protein PhoH
HLG75_02445	COG0739	heme binding
HLG75_02445	COG1196	nuclear chromosome segregation
HLG75_02445	COG0741	lytic transglycosylase activity
HLG75_02475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLG75_02480	COG1183	phosphatidylcholine synthase activity
HLG75_02525	COG1960	acyl-CoA dehydrogenase activity
HLG75_02530	COG1309	transcriptional regulator
HLG75_02545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG75_02550	COG1960	acyl-CoA dehydrogenase activity
HLG75_02570	COG2969	positive regulation of protein catabolic process
HLG75_02580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLG75_02590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLG75_02595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLG75_02600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLG75_02620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLG75_02630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLG75_02635	COG1408	metallophosphoesterase
HLG75_02645	COG2199	diguanylate cyclase activity
HLG75_02705	COG1607	acyl-coa hydrolase
HLG75_02735	COG2350	Protein conserved in bacteria
HLG75_02745	COG0613	PHP domain protein
HLG75_02750	COG3781	membrane
HLG75_02760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLG75_02765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLG75_02775	COG1862	Preprotein translocase
HLG75_02805	COG0582	viral genome integration into host DNA
HLG75_02855	COG2205	protein histidine kinase activity
HLG75_02860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HLG75_02880	COG0726	polysaccharide deacetylase
HLG75_02885	COG0463	Glycosyl transferase, family 2
HLG75_02890	COG0438	transferase activity, transferring glycosyl groups
HLG75_02905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLG75_02955	COG1960	acyl-CoA dehydrogenase activity
HLG75_02960	COG1960	acyl-CoA dehydrogenase activity
HLG75_02970	COG2205	protein histidine kinase activity
HLG75_02975	COG0745	RESPONSE REGULATOR receiver
HLG75_02980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLG75_03000	COG2096	Adenosyltransferase
HLG75_03005	COG4206	TonB-dependent receptor
HLG75_03050	COG0285	dihydrofolate synthase activity
HLG75_03070	COG0450	alkyl hydroperoxide reductase
HLG75_03085	COG0477	Major facilitator Superfamily
HLG75_03090	COG1272	protein, Hemolysin III
HLG75_03100	COG2153	protein acetylation
HLG75_03120	COG0183	Belongs to the thiolase family
HLG75_03125	COG2207	Transcriptional regulator
HLG75_03145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG75_03165	COG0183	Belongs to the thiolase family
HLG75_03175	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HLG75_03175	COG2885	chlorophyll binding
HLG75_03185	COG1690	Belongs to the RtcB family
HLG75_03190	COG0833	amino acid
HLG75_03200	COG2233	PERMEase
HLG75_03230	COG2094	Belongs to the DNA glycosylase MPG family
HLG75_03235	COG4772	TonB-dependent receptor
HLG75_03240	COG1902	pentaerythritol trinitrate reductase activity
HLG75_03245	COG0679	Auxin Efflux Carrier
HLG75_03255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG75_03260	COG0354	folic acid binding
HLG75_03270	COG3189	MarR family transcriptional regulator
HLG75_03275	COG2824	Alkylphosphonate utilization operon protein PhnA
HLG75_03280	COG3422	double-strand break repair
HLG75_03320	COG0840	transmembrane signaling receptor activity
HLG75_03340	COG5510	response to toxic substance
HLG75_03350	COG2832	Protein of unknown function (DUF454)
HLG75_03355	COG1376	ErfK ybiS ycfS ynhG family protein
HLG75_03395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLG75_03405	COG1289	transmembrane transporter activity
HLG75_03410	COG2814	Major facilitator Superfamily
HLG75_03430	COG1115	amino acid carrier protein
HLG75_03435	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLG75_03440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG75_03445	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HLG75_03450	COG3590	peptidase
HLG75_03475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG75_03485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLG75_03490	COG1077	Cell shape determining protein MreB Mrl
HLG75_03495	COG1792	Involved in formation and maintenance of cell shape
HLG75_03500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLG75_03505	COG0424	maF-like protein
HLG75_03510	COG1530	ribonuclease E activity
HLG75_03520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG75_03530	COG0560	Phosphoserine phosphatase
HLG75_03540	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG75_03565	COG2207	Transcriptional regulator
HLG75_03585	COG1113	amino acid transport
HLG75_03590	COG2828	Protein conserved in bacteria
HLG75_03595	COG0142	geranyltranstransferase activity
HLG75_03600	COG2315	Protein conserved in bacteria
HLG75_03615	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLG75_03635	COG2194	sulfuric ester hydrolase activity
HLG75_03640	COG0745	RESPONSE REGULATOR receiver
HLG75_03645	COG0642	Histidine kinase
HLG75_03655	COG0004	ammonium transporteR
HLG75_03660	COG0583	DNA-binding transcription factor activity
HLG75_03680	COG0525	valine-tRNA ligase activity
HLG75_03690	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_03700	COG0393	Putative heavy-metal-binding
HLG75_03705	COG0393	Putative heavy-metal-binding
HLG75_03710	COG1538	Outer membrane efflux protein
HLG75_03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG75_03725	COG0671	phosphoesterase, PA-phosphatase related
HLG75_03755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLG75_03770	COG1648	precorrin-2 dehydrogenase activity
HLG75_03770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLG75_03775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLG75_03780	COG1733	regulation of RNA biosynthetic process
HLG75_03790	COG0531	amino acid
HLG75_03805	COG0321	lipoyl(octanoyl) transferase activity
HLG75_03810	COG2921	Belongs to the UPF0250 family
HLG75_03850	COG2009	succinate dehydrogenase
HLG75_03855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLG75_03860	COG1053	succinate dehydrogenase
HLG75_03865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLG75_03890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG75_03915	COG2321	neutral zinc metallopeptidase
HLG75_03935	COG2843	Capsule synthesis protein
HLG75_03950	COG0589	response to stress
HLG75_03960	COG0251	oxidation-reduction process
HLG75_03965	COG1309	transcriptional regulator
HLG75_03980	COG0505	Belongs to the CarA family
HLG75_04005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG75_04010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLG75_04060	COG0477	Major facilitator Superfamily
HLG75_04065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HLG75_04080	COG1597	lipid kinase activity
HLG75_04085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG75_04105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG75_04110	COG0584	glycerophosphoryl diester phosphodiesterase
HLG75_04130	COG0741	lytic transglycosylase activity
HLG75_04150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLG75_04160	COG0582	viral genome integration into host DNA
HLG75_04185	COG1309	transcriptional regulator
HLG75_04230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HLG75_04230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HLG75_04250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG75_04260	COG3811	Belongs to the UPF0386 family
HLG75_04315	COG0778	Nitroreductase
HLG75_04330	COG1929	Belongs to the glycerate kinase type-1 family
HLG75_04335	COG0243	molybdopterin cofactor binding
HLG75_04340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLG75_04345	COG3339	Conserved Protein
HLG75_04355	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HLG75_04370	COG1113	amino acid transport
HLG75_04380	COG0019	diaminopimelate decarboxylase activity
HLG75_04390	COG1280	lysine exporter protein (LysE YggA)
HLG75_04395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLG75_04425	COG0463	Glycosyl transferase, family 2
HLG75_04445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG75_04480	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLG75_04485	COG1136	(ABC) transporter
HLG75_04490	COG2333	competence protein COMEC
HLG75_04490	COG0658	competence protein
HLG75_04500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HLG75_04500	COG0616	signal peptide processing
HLG75_04505	COG0596	Alpha beta hydrolase
HLG75_04510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLG75_04520	COG0628	permease
HLG75_04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG75_04575	COG0823	Involved in the tonB-independent uptake of proteins
HLG75_04595	COG0824	Thioesterase
HLG75_04600	COG1473	amidohydrolase
HLG75_04620	COG0047	phosphoribosylformylglycinamidine synthase activity
HLG75_04620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLG75_04625	COG2814	Major facilitator Superfamily
HLG75_04635	COG1024	Enoyl-CoA hydratase
HLG75_04640	COG1056	cytidyltransferase-related domain
HLG75_04640	COG1051	belongs to the nudix hydrolase family
HLG75_04650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLG75_04665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HLG75_04680	COG4625	pathogenesis
HLG75_04685	COG0583	DNA-binding transcription factor activity
HLG75_04690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLG75_04695	COG4208	sulfate ABC transporter
HLG75_04700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLG75_04710	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLG75_04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLG75_04720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLG75_04740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG75_04750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLG75_04760	COG0681	Belongs to the peptidase S26 family
HLG75_04775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLG75_04785	COG1381	Involved in DNA repair and RecF pathway recombination
HLG75_04790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLG75_04800	COG4221	oxidoreductase activity
HLG75_04830	COG0443	Heat shock 70 kDa protein
HLG75_04840	COG0436	Aminotransferase
HLG75_04860	COG0556	nucleotide-excision repair
HLG75_04915	COG2070	2-Nitropropane dioxygenase
HLG75_04945	COG1215	transferase activity, transferring glycosyl groups
HLG75_04960	COG0415	Belongs to the DNA photolyase family
HLG75_04970	COG1252	NADH dehydrogenase
HLG75_04975	COG1686	Belongs to the peptidase S11 family
HLG75_04990	COG1187	pseudouridine synthase activity
HLG75_05015	COG0477	Major facilitator Superfamily
HLG75_05020	COG0583	DNA-binding transcription factor activity
HLG75_05035	COG0612	Peptidase, M16
HLG75_05060	COG0352	thiamine-phosphate diphosphorylase activity
HLG75_05095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG75_05105	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG75_05120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLG75_05125	COG0076	glutamate decarboxylase activity
HLG75_05135	COG1522	sequence-specific DNA binding
HLG75_05140	COG3961	Belongs to the TPP enzyme family
HLG75_05145	COG1113	amino acid transport
HLG75_05150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLG75_05155	COG0573	inorganic phosphate transmembrane transporter activity
HLG75_05165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLG75_05170	COG0616	signal peptide processing
HLG75_05205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLG75_05210	COG1686	Belongs to the peptidase S11 family
HLG75_05235	COG0583	DNA-binding transcription factor activity
HLG75_05240	COG1067	ATP-dependent peptidase activity
HLG75_05265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLG75_05285	COG1966	Carbon starvation protein
HLG75_05290	COG2879	small protein
HLG75_05330	COG1335	isochorismatase
HLG75_05335	COG0583	DNA-binding transcription factor activity
HLG75_05350	COG0596	Alpha beta hydrolase
HLG75_05360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG75_05400	COG1741	Belongs to the pirin family
HLG75_05410	COG2964	Protein conserved in bacteria
HLG75_05425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG75_05430	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLG75_05435	COG4605	iron ion homeostasis
HLG75_05440	COG4604	ABC transporter, ATP-binding protein
HLG75_05445	COG4607	ABC-type enterochelin transport system periplasmic component
HLG75_05450	COG4774	siderophore transport
HLG75_05460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLG75_05465	COG1021	2,3-dihydroxybenzoate-AMP ligase
HLG75_05470	COG3433	isochorismatase activity
HLG75_05470	COG1535	isochorismatase
HLG75_05485	COG1132	(ABC) transporter
HLG75_05495	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HLG75_05520	COG3739	integral membrane protein
HLG75_05550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLG75_05580	COG0308	aminopeptidase N
HLG75_05585	COG0512	Glutamine amidotransferase of anthranilate synthase
HLG75_05595	COG3104	oligopeptide transport
HLG75_05600	COG0174	glutamine synthetase
HLG75_05610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLG75_05645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLG75_05650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLG75_05655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLG75_05675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLG75_05680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLG75_05685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HLG75_05700	COG1960	acyl-CoA dehydrogenase activity
HLG75_05705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG75_05710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG75_05720	COG2223	nitrite transmembrane transporter activity
HLG75_05730	COG0024	Methionine aminopeptidase
HLG75_05735	COG0052	Belongs to the universal ribosomal protein uS2 family
HLG75_05750	COG2207	Transcriptional regulator
HLG75_05775	COG2951	lytic endotransglycosylase activity
HLG75_05780	COG0772	Belongs to the SEDS family
HLG75_05795	COG0842	Transport permease protein
HLG75_05800	COG1131	(ABC) transporter
HLG75_05805	COG0582	viral genome integration into host DNA
HLG75_06080	COG1598	PFAM Uncharacterised protein family UPF0150
HLG75_06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG75_06210	COG4215	(ABC) transporter
HLG75_06215	COG4160	amino acid transport
HLG75_06220	COG4598	ABC transporter
HLG75_06230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLG75_06240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG75_06255	COG1720	tRNA m6t6A37 methyltransferase activity
HLG75_06275	COG0745	RESPONSE REGULATOR receiver
HLG75_06280	COG0642	Histidine kinase
HLG75_06290	COG0494	nUDIX hydrolase
HLG75_06300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLG75_06305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HLG75_06310	COG3139	Protein of unknown function (DUF1315)
HLG75_06315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLG75_06320	COG1301	dicarboxylic acid transport
HLG75_06325	COG1960	acyl-CoA dehydrogenase activity
HLG75_06330	COG2819	hydrolase of the alpha beta superfamily
HLG75_06340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLG75_06350	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLG75_06370	COG1690	Belongs to the RtcB family
HLG75_06375	COG1234	tRNA 3'-trailer cleavage
HLG75_06380	COG4650	regulator
HLG75_06410	COG2363	Small membrane protein
HLG75_06430	COG0513	Belongs to the DEAD box helicase family
HLG75_06440	COG0778	Nitroreductase
HLG75_06470	COG1286	toxin biosynthetic process
HLG75_06495	COG4783	chaperone-mediated protein folding
HLG75_06500	COG1610	YqeY-like protein
HLG75_06530	COG0515	serine threonine protein kinase
HLG75_06530	COG2815	serine threonine protein kinase
HLG75_06600	COG3111	PFAM Bacterial OB fold (BOF) protein
HLG75_06625	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLG75_06630	COG0786	glutamate:sodium symporter activity
HLG75_06640	COG2186	Transcriptional regulator
HLG75_06690	COG0477	Major facilitator Superfamily
HLG75_06695	COG1051	belongs to the nudix hydrolase family
HLG75_06725	COG2995	paraquat-inducible protein a
HLG75_06730	COG3008	intermembrane lipid transfer
HLG75_06730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLG75_06745	COG1794	racemase activity, acting on amino acids and derivatives
HLG75_06775	COG1301	dicarboxylic acid transport
HLG75_06785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG75_06790	COG2011	ABC-type metal ion transport system permease component
HLG75_06795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG75_06800	COG1464	Belongs to the NlpA lipoprotein family
HLG75_06805	COG0151	Belongs to the GarS family
HLG75_06810	COG0138	bifunctional purine biosynthesis protein purh
HLG75_06815	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HLG75_06845	COG2308	Evidence 4 Homologs of previously reported genes of
HLG75_06855	COG1305	Transglutaminase-like
HLG75_06865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLG75_06870	COG0305	Participates in initiation and elongation during chromosome replication
HLG75_06895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLG75_06905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLG75_06910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLG75_06935	COG1649	PFAM Uncharacterised BCR, COG1649
HLG75_06935	COG0726	polysaccharide deacetylase
HLG75_06940	COG1215	transferase activity, transferring glycosyl groups
HLG75_06945	COG3658	cytochrome
HLG75_06955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG75_06970	COG0583	DNA-binding transcription factor activity
HLG75_07000	COG1960	acyl-CoA dehydrogenase activity
HLG75_07005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG75_07010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG75_07025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLG75_07035	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HLG75_07040	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HLG75_07045	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HLG75_07050	COG2205	protein histidine kinase activity
HLG75_07055	COG0745	RESPONSE REGULATOR receiver
HLG75_07060	COG0174	glutamine synthetase
HLG75_07080	COG0729	surface antigen
HLG75_07105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLG75_07110	COG2814	Major facilitator Superfamily
HLG75_07125	COG0583	DNA-binding transcription factor activity
HLG75_07140	COG1187	pseudouridine synthase activity
HLG75_07160	COG0802	atpase or kinase
HLG75_07165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLG75_07175	COG1923	regulation of RNA biosynthetic process
HLG75_07180	COG0697	spore germination
HLG75_07205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG75_07210	COG0519	Catalyzes the synthesis of GMP from XMP
HLG75_07210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLG75_07215	COG4302	ethanolamine ammonia-lyase activity
HLG75_07220	COG4303	Ethanolamine ammonia lyase large subunit
HLG75_07225	COG0531	amino acid
HLG75_07245	COG1454	alcohol dehydrogenase
HLG75_07250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLG75_07275	COG0308	aminopeptidase N
HLG75_07315	COG1605	Chorismate mutase
HLG75_07330	COG1309	transcriptional regulator
HLG75_07340	COG0668	transmembrane transport
HLG75_07370	COG4773	Receptor
HLG75_07390	COG0488	(ABC) transporter
HLG75_07395	COG0589	response to stress
HLG75_07415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLG75_07425	COG3135	benzoate transporter
HLG75_07430	COG1522	sequence-specific DNA binding
HLG75_07440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLG75_07445	COG0583	DNA-binding transcription factor activity
HLG75_07455	COG0183	Belongs to the thiolase family
HLG75_07465	COG2030	dehydratase
HLG75_07485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLG75_07495	COG0824	Thioesterase
HLG75_07500	COG1454	alcohol dehydrogenase
HLG75_07510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLG75_07530	COG0069	glutamate synthase activity
HLG75_07550	COG2814	Major facilitator Superfamily
HLG75_07565	COG0511	ligase activity, forming carbon-carbon bonds
HLG75_07585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG75_07585	COG1116	anion transmembrane transporter activity
HLG75_07590	COG0745	RESPONSE REGULATOR receiver
HLG75_07600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG75_07600	COG2146	nitrite reductase [NAD(P)H] activity
HLG75_07605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG75_07610	COG0243	molybdopterin cofactor binding
HLG75_07620	COG0243	molybdopterin cofactor binding
HLG75_07625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLG75_07640	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLG75_07640	COG0315	cyclic pyranopterin monophosphate synthase activity
HLG75_07645	COG0303	'Molybdopterin
HLG75_07655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG75_07660	COG0697	spore germination
HLG75_07680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HLG75_07685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG75_07740	COG2204	response regulator
HLG75_07745	COG3852	Histidine kinase
HLG75_07770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLG75_07775	COG0575	Belongs to the CDS family
HLG75_07790	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG75_07810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLG75_07825	COG2137	regulation of response to DNA damage stimulus
HLG75_07835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLG75_07840	COG1011	Hydrolase
HLG75_07865	COG1522	sequence-specific DNA binding
HLG75_07875	COG1113	amino acid transport
HLG75_07890	COG0659	secondary active sulfate transmembrane transporter activity
HLG75_07895	COG2135	peptidase activity
HLG75_07910	COG3300	MHYT domain
HLG75_07910	COG5001	Diguanylate cyclase
HLG75_07925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLG75_07925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLG75_07925	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLG75_07930	COG1105	Belongs to the carbohydrate kinase PfkB family
HLG75_07935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLG75_07935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG75_07965	COG0024	Methionine aminopeptidase
HLG75_07970	COG0583	DNA-binding transcription factor activity
HLG75_07980	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLG75_07985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLG75_07990	COG0516	GMP reductase activity
HLG75_07990	COG0517	IMP dehydrogenase activity
HLG75_08015	COG0552	protein localization to endoplasmic reticulum
HLG75_08025	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HLG75_08040	COG4890	Cyd operon protein YbgT
HLG75_08045	COG1294	oxidase, subunit
HLG75_08060	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLG75_08070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLG75_08075	COG4774	siderophore transport
HLG75_08090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLG75_08095	COG0569	domain protein
HLG75_08100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLG75_08130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HLG75_08135	COG0542	response to heat
HLG75_08160	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG75_08160	COG1902	pentaerythritol trinitrate reductase activity
HLG75_08205	COG2323	membrane
HLG75_08210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLG75_08220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLG75_08225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG75_08230	COG0183	Belongs to the thiolase family
HLG75_08235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLG75_08240	COG0596	Alpha beta hydrolase
HLG75_08245	COG2271	Major facilitator Superfamily
HLG75_08250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLG75_08255	COG3485	protocatechuate 3,4-dioxygenase
HLG75_08260	COG3485	protocatechuate 3,4-dioxygenase
HLG75_08265	COG0710	3-dehydroquinate dehydratase activity
HLG75_08270	COG3420	alginic acid biosynthetic process
HLG75_08275	COG3659	wide pore channel activity
HLG75_08280	COG4993	Dehydrogenase
HLG75_08290	COG2391	methyltransferase activity
HLG75_08305	COG1414	Transcriptional regulator
HLG75_08310	COG0583	DNA-binding transcription factor activity
HLG75_08315	COG1960	acyl-CoA dehydrogenase activity
HLG75_08340	COG2814	Major facilitator Superfamily
HLG75_08350	COG0154	amidase activity
HLG75_08370	COG4638	Rieske (2fe-2S)
HLG75_08380	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_08390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG75_08410	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_08420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG75_08425	COG0183	Belongs to the thiolase family
HLG75_08430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLG75_08435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLG75_08445	COG4829	muconolactone delta-isomerase
HLG75_08450	COG4948	Mandelate Racemase Muconate Lactonizing
HLG75_08455	COG0583	DNA-binding transcription factor activity
HLG75_08465	COG2186	Transcriptional regulator
HLG75_08485	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_08500	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG75_08500	COG1902	pentaerythritol trinitrate reductase activity
HLG75_08510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLG75_08520	COG0789	Transcriptional regulator
HLG75_08545	COG1309	transcriptional regulator
HLG75_08550	COG0583	DNA-binding transcription factor activity
HLG75_08555	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_08560	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_08565	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_08575	COG1960	acyl-CoA dehydrogenase activity
HLG75_08585	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_08660	COG2188	Transcriptional regulator
HLG75_08675	COG0583	DNA-binding transcription factor activity
HLG75_08690	COG1566	PFAM secretion protein HlyD family protein
HLG75_08705	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_08710	COG0129	dihydroxy-acid dehydratase activity
HLG75_08720	COG0583	DNA-binding transcription factor activity
HLG75_08725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLG75_08735	COG2084	Dehydrogenase
HLG75_08740	COG2207	Transcriptional regulator
HLG75_08745	COG1064	alcohol dehydrogenase
HLG75_08760	COG1120	ATPase activity
HLG75_08855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLG75_08890	COG2856	Zn peptidase
HLG75_08940	COG2207	Transcriptional regulator
HLG75_08955	COG2205	protein histidine kinase activity
HLG75_08960	COG0745	RESPONSE REGULATOR receiver
HLG75_08965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG75_08970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG75_08985	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_08990	COG3539	Fimbrial protein
HLG75_09015	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HLG75_09025	COG0753	catalase activity
HLG75_09255	COG1535	isochorismatase
HLG75_09255	COG3433	isochorismatase activity
HLG75_09260	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_09265	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLG75_09270	COG4149	molybdate abc transporter
HLG75_09275	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLG75_09285	COG4638	Rieske (2fe-2S)
HLG75_09290	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLG75_09295	COG0543	2 iron, 2 sulfur cluster binding
HLG75_09295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG75_09310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG75_09320	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_09335	COG2207	Transcriptional regulator
HLG75_09340	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_09345	COG2610	gluconate transmembrane transporter activity
HLG75_09355	COG1309	transcriptional regulator
HLG75_09375	COG0583	DNA-binding transcription factor activity
HLG75_09390	COG2031	fatty acid transporter
HLG75_09395	COG0183	Belongs to the thiolase family
HLG75_09400	COG0583	DNA-binding transcription factor activity
HLG75_09405	COG0583	DNA-binding transcription factor activity
HLG75_09420	COG1027	Aspartate ammonia-lyase
HLG75_09430	COG0477	Major facilitator Superfamily
HLG75_09450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG75_09455	COG4521	taurine ABC transporter
HLG75_09470	COG2188	Transcriptional regulator
HLG75_09480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HLG75_09485	COG1733	regulation of RNA biosynthetic process
HLG75_09490	COG3708	Transcriptional regulator
HLG75_09490	COG2207	Transcriptional regulator
HLG75_09505	COG0730	response to heat
HLG75_09515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG75_09515	COG3453	Protein conserved in bacteria
HLG75_09525	COG3781	membrane
HLG75_09530	COG1063	alcohol dehydrogenase
HLG75_09540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLG75_09545	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLG75_09550	COG0022	dehydrogenase e1 component
HLG75_09555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLG75_09560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLG75_09575	COG3706	GGDEF domain
HLG75_09590	COG0133	tryptophan synthase activity
HLG75_09600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLG75_09630	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HLG75_09635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLG75_09660	COG2226	methyltransferase
HLG75_09715	COG0842	Transport permease protein
HLG75_09720	COG0842	Transport permease protein
HLG75_09725	COG1131	(ABC) transporter
HLG75_09740	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLG75_09745	COG4773	Receptor
HLG75_09765	COG0730	response to heat
HLG75_09770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLG75_09785	COG0406	alpha-ribazole phosphatase activity
HLG75_09790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HLG75_09835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG75_09845	COG4264	IucA IucC family
HLG75_09850	COG4264	IucA IucC family
HLG75_09855	COG2814	Major facilitator Superfamily
HLG75_09870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLG75_09885	COG1960	acyl-CoA dehydrogenase activity
HLG75_09890	COG1960	acyl-CoA dehydrogenase activity
HLG75_09895	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLG75_09900	COG2207	Transcriptional regulator
HLG75_09905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG75_09910	COG0776	regulation of translation
HLG75_09935	COG0822	iron-sulfur transferase activity
HLG75_09940	COG0316	Belongs to the HesB IscA family
HLG75_09970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLG75_09990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HLG75_09995	COG0702	epimerase
HLG75_10030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLG75_10040	COG0339	signal peptide processing
HLG75_10090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLG75_10435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLG75_10465	COG0776	regulation of translation
HLG75_10530	COG0084	hydrolase, TatD family'
HLG75_10550	COG1663	tetraacyldisaccharide 4'-kinase activity
HLG75_10555	COG1132	(ABC) transporter
HLG75_10565	COG0811	peptide transport
HLG75_10570	COG1475	DNA binding
HLG75_10575	COG1192	Involved in chromosome partitioning
HLG75_10585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLG75_10600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLG75_10605	COG0191	fructose-bisphosphate aldolase activity
HLG75_10625	COG0424	maF-like protein
HLG75_10630	COG2850	peptidyl-arginine hydroxylation
HLG75_10640	COG0640	Transcriptional regulator
HLG75_10650	COG3619	membrane
HLG75_10655	COG3122	Protein conserved in bacteria
HLG75_10660	COG1132	(ABC) transporter
HLG75_10680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLG75_10685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLG75_10695	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLG75_10695	COG0506	proline dehydrogenase activity
HLG75_10695	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLG75_10700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLG75_10715	COG3698	Phosphodiester glycosidase
HLG75_10725	COG2353	YceI-like domain
HLG75_10735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLG75_10780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLG75_10780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLG75_10805	COG3539	Fimbrial protein
HLG75_10810	COG3121	Chaperone
HLG75_10835	COG0697	spore germination
HLG75_10845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLG75_10855	COG0583	DNA-binding transcription factor activity
HLG75_10875	COG1309	transcriptional regulator
HLG75_10890	COG1522	sequence-specific DNA binding
HLG75_10900	COG1126	abc transporter atp-binding protein
HLG75_10905	COG0765	amino acid transport
HLG75_10910	COG0765	amino acid transport
HLG75_10940	COG1464	Belongs to the NlpA lipoprotein family
HLG75_10950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLG75_10955	COG2011	ABC-type metal ion transport system permease component
HLG75_10960	COG0012	GTP binding
HLG75_10985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLG75_11025	COG0386	Belongs to the glutathione peroxidase family
HLG75_11035	COG0436	Aminotransferase
HLG75_11040	COG1301	dicarboxylic acid transport
HLG75_11075	COG3634	alkyl hydroperoxide reductase activity
HLG75_11090	COG0583	DNA-binding transcription factor activity
HLG75_11095	COG0798	PFAM Bile acid sodium symporter
HLG75_11100	COG0640	Transcriptional regulator
HLG75_11115	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLG75_11125	COG0583	DNA-binding transcription factor activity
HLG75_11135	COG1953	Uracil, thiamine, allantoin
HLG75_11145	COG2175	clavaminate synthase activity
HLG75_11150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG75_11155	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HLG75_11160	COG4521	taurine ABC transporter
HLG75_11170	COG0477	Major facilitator Superfamily
HLG75_11190	COG1271	oxidase subunit
HLG75_11195	COG1294	oxidase, subunit
HLG75_11205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG75_11225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLG75_11245	COG3052	prosthetic group binding
HLG75_11250	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HLG75_11260	COG0583	DNA-binding transcription factor activity
HLG75_11270	COG2814	Major facilitator Superfamily
HLG75_11285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG75_11290	COG1346	cytolysis
HLG75_11300	COG0583	DNA-binding transcription factor activity
HLG75_11305	COG0625	glutathione transferase activity
HLG75_11310	COG0625	glutathione transferase activity
HLG75_11315	COG0583	DNA-binding transcription factor activity
HLG75_11330	COG1045	serine acetyltransferase
HLG75_11335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLG75_11340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLG75_11365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG75_11370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG75_11380	COG0765	amino acid transport
HLG75_11385	COG0765	amino acid transport
HLG75_11405	COG0784	Response regulator, receiver
HLG75_11405	COG2205	protein histidine kinase activity
HLG75_11445	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_11485	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_11500	COG0583	DNA-binding transcription factor activity
HLG75_11520	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_11525	COG1309	transcriptional regulator
HLG75_11530	COG1960	acyl-CoA dehydrogenase activity
HLG75_11535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLG75_11540	COG1024	Enoyl-CoA hydratase
HLG75_11545	COG4770	biotin carboxylase activity
HLG75_11555	COG0583	DNA-binding transcription factor activity
HLG75_11575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLG75_11580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLG75_11595	COG3842	ATPase activity
HLG75_11600	COG1840	ABC-type Fe3 transport system, periplasmic component
HLG75_11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG75_11620	COG1414	Transcriptional regulator
HLG75_11630	COG0583	DNA-binding transcription factor activity
HLG75_11635	COG3038	cytochrome b561
HLG75_11640	COG0753	catalase activity
HLG75_11670	COG2050	protein possibly involved in aromatic compounds catabolism
HLG75_11680	COG3327	negative regulation of DNA-templated transcription, initiation
HLG75_11685	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HLG75_11690	COG0183	Belongs to the thiolase family
HLG75_11695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG75_11700	COG1024	Enoyl-CoA hydratase
HLG75_11705	COG1024	Enoyl-CoA hydratase
HLG75_11710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG75_11715	COG2151	metal-sulfur cluster biosynthetic enzyme
HLG75_11720	COG3396	Phenylacetate-CoA oxygenase
HLG75_11725	COG3460	Phenylacetate-CoA oxygenase
HLG75_11730	COG3396	Phenylacetate-CoA oxygenase
HLG75_11735	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_11735	COG2030	dehydratase
HLG75_11740	COG1760	l-serine dehydratase
HLG75_11745	COG0531	amino acid
HLG75_11750	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_11775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLG75_11795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG75_11805	COG0789	Transcriptional regulator
HLG75_11815	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLG75_11830	COG2807	transmembrane transport
HLG75_11835	COG0590	tRNA wobble adenosine to inosine editing
HLG75_11940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLG75_11965	COG1116	anion transmembrane transporter activity
HLG75_11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLG75_11980	COG0864	Transcriptional regulator
HLG75_12000	COG1733	regulation of RNA biosynthetic process
HLG75_12005	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLG75_12010	COG0439	Biotin carboxylase
HLG75_12025	COG1063	alcohol dehydrogenase
HLG75_12035	COG1309	transcriptional regulator
HLG75_12040	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_12050	COG0038	chloride channel
HLG75_12055	COG4770	biotin carboxylase activity
HLG75_12075	COG1914	H( )-stimulated, divalent metal cation uptake system
HLG75_12080	COG0583	DNA-binding transcription factor activity
HLG75_12115	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLG75_12135	COG2814	Major facilitator Superfamily
HLG75_12150	COG0598	Magnesium transport protein CorA
HLG75_12155	COG1560	Kdo2-lipid A biosynthetic process
HLG75_12170	COG1522	sequence-specific DNA binding
HLG75_12185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HLG75_12195	COG4122	O-methyltransferase activity
HLG75_12225	COG1538	Outer membrane efflux protein
HLG75_12235	COG1137	ATPase activity
HLG75_12240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HLG75_12250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HLG75_12255	COG0517	IMP dehydrogenase activity
HLG75_12255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLG75_12295	COG2814	Major facilitator Superfamily
HLG75_12330	COG1278	Cold shock
HLG75_12335	COG1280	lysine exporter protein (LysE YggA)
HLG75_12370	COG1570	exodeoxyribonuclease VII activity
HLG75_12420	COG0583	DNA-binding transcription factor activity
HLG75_12425	COG4638	Rieske (2fe-2S)
HLG75_12430	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HLG75_12435	COG0543	2 iron, 2 sulfur cluster binding
HLG75_12435	COG0633	Ferredoxin
HLG75_12440	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_12445	COG3135	benzoate transporter
HLG75_12450	COG2814	Major facilitator Superfamily
HLG75_12465	COG1643	Atp-dependent helicase
HLG75_12470	COG0450	alkyl hydroperoxide reductase
HLG75_12480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HLG75_12490	COG3634	alkyl hydroperoxide reductase activity
HLG75_12510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLG75_12515	COG0625	glutathione transferase activity
HLG75_12525	COG2885	chlorophyll binding
HLG75_12560	COG0542	response to heat
HLG75_12575	COG1765	OsmC-like protein
HLG75_12585	COG0667	Aldo Keto reductase
HLG75_12600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HLG75_12610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLG75_12735	COG3566	protein conserved in bacteria
HLG75_12745	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_12755	COG3567	Phage-associated protein, HI1409 family
HLG75_12760	COG5410	chromosome segregation
HLG75_12865	COG4197	protein conserved in bacteria, prophage-related
HLG75_12870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLG75_12925	COG0527	aspartate kinase activity
HLG75_12935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HLG75_12945	COG3038	cytochrome b561
HLG75_12950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HLG75_12955	COG2252	PERMEase
HLG75_12965	COG2072	flavoprotein involved in K transport
HLG75_12980	COG1741	Belongs to the pirin family
HLG75_12985	COG1309	transcriptional regulator
HLG75_12995	COG0300	oxidoreductase activity
HLG75_13000	COG2072	flavoprotein involved in K transport
HLG75_13005	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLG75_13050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLG75_13065	COG2814	Major facilitator Superfamily
HLG75_13070	COG1024	Enoyl-CoA hydratase
HLG75_13075	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_13085	COG1960	acyl-CoA dehydrogenase activity
HLG75_13110	COG2186	Transcriptional regulator
HLG75_13115	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_13125	COG4948	Mandelate Racemase Muconate Lactonizing
HLG75_13130	COG2271	Major facilitator Superfamily
HLG75_13135	COG2721	sulfolactate sulfo-lyase activity
HLG75_13140	COG0697	spore germination
HLG75_13170	COG1113	amino acid transport
HLG75_13190	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_13220	COG1113	amino acid transport
HLG75_13270	COG0583	DNA-binding transcription factor activity
HLG75_13280	COG0251	oxidation-reduction process
HLG75_13300	COG1902	pentaerythritol trinitrate reductase activity
HLG75_13300	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG75_13315	COG3706	GGDEF domain
HLG75_13315	COG4251	negative regulation of phosphorylation
HLG75_13315	COG2203	Gaf domain
HLG75_13315	COG5001	Diguanylate cyclase
HLG75_13325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLG75_13345	COG4172	Belongs to the ABC transporter superfamily
HLG75_13350	COG4239	(ABC) transporter, permease
HLG75_13355	COG4174	ABC transporter (Permease)
HLG75_13365	COG0741	lytic transglycosylase activity
HLG75_13365	COG1388	LysM domain
HLG75_13365	COG0741	lytic transglycosylase activity
HLG75_13365	COG1388	LysM domain
HLG75_13370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLG75_13410	COG0583	DNA-binding transcription factor activity
HLG75_13415	COG1279	arginine transmembrane transporter activity
HLG75_13435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG75_13440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG75_13445	COG0006	proline dipeptidase activity
HLG75_13475	COG2194	sulfuric ester hydrolase activity
HLG75_13525	COG0739	heme binding
HLG75_13535	COG1598	PFAM Uncharacterised protein family UPF0150
HLG75_13825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLG75_13855	COG3384	dioxygenase
HLG75_13865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLG75_13870	COG2878	Part of a membrane complex involved in electron transport
HLG75_13875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLG75_13900	COG0768	penicillin binding
HLG75_13905	COG0742	ribosomal rna small subunit methyltransferase
HLG75_13920	COG0830	nickel cation binding
HLG75_13930	COG0804	urea catabolic process
HLG75_13975	COG1253	flavin adenine dinucleotide binding
HLG75_13980	COG2851	Citrate transporter
HLG75_14030	COG1773	rubredoxin
HLG75_14035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLG75_14045	COG0583	DNA-binding transcription factor activity
HLG75_14075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLG75_14080	COG4181	ATPase activity
HLG75_14125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLG75_14145	COG0306	phosphate transporter
HLG75_14155	COG3958	Transketolase
HLG75_14160	COG3959	Transketolase, thiamine diphosphate binding domain
HLG75_14165	COG2271	Major facilitator Superfamily
HLG75_14170	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_14175	COG0583	DNA-binding transcription factor activity
HLG75_14195	COG2223	nitrite transmembrane transporter activity
HLG75_14200	COG2207	Transcriptional regulator
HLG75_14205	COG2066	Belongs to the glutaminase family
HLG75_14210	COG0242	peptide deformylase activity
HLG75_14215	COG0477	Major facilitator Superfamily
HLG75_14225	COG0028	Belongs to the TPP enzyme family
HLG75_14240	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_14245	COG2267	carboxylic ester hydrolase activity
HLG75_14255	COG2271	Major facilitator Superfamily
HLG75_14260	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLG75_14270	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_14290	COG1414	Transcriptional regulator
HLG75_14305	COG1024	Enoyl-CoA hydratase
HLG75_14315	COG1215	transferase activity, transferring glycosyl groups
HLG75_14320	COG0726	polysaccharide deacetylase
HLG75_14320	COG1649	PFAM Uncharacterised BCR, COG1649
HLG75_14330	COG4681	YaeQ
HLG75_14340	COG0523	cobalamin synthesis protein
HLG75_14350	COG1607	acyl-coa hydrolase
HLG75_14360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG75_14365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLG75_14370	COG1309	transcriptional regulator
HLG75_14395	COG2040	homocysteine
HLG75_14400	COG0531	amino acid
HLG75_14425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG75_14430	COG0477	Major facilitator Superfamily
HLG75_14485	COG0629	single-stranded DNA binding
HLG75_14530	COG0582	viral genome integration into host DNA
HLG75_14540	COG0405	Gamma-glutamyltransferase
HLG75_14545	COG2814	Major facilitator Superfamily
HLG75_14555	COG2050	protein possibly involved in aromatic compounds catabolism
HLG75_14570	COG1090	epimerase
HLG75_14590	COG0420	3'-5' exonuclease activity
HLG75_14615	COG0735	belongs to the Fur family
HLG75_14620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLG75_14640	COG0121	glutamine amidotransferase
HLG75_14655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG75_14665	COG0210	DNA helicase
HLG75_14670	COG2885	chlorophyll binding
HLG75_14675	COG0204	Acyl-transferase
HLG75_14690	COG2894	cell division
HLG75_14705	COG1280	lysine exporter protein (LysE YggA)
HLG75_14710	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLG75_14710	COG1674	ftsk spoiiie
HLG75_14715	COG0492	ferredoxin-NADP+ reductase activity
HLG75_14720	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HLG75_14730	COG0456	acetyltransferase
HLG75_14790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HLG75_14790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLG75_14810	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_14830	COG0473	3-isopropylmalate dehydrogenase activity
HLG75_14835	COG0583	DNA-binding transcription factor activity
HLG75_14855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLG75_14880	COG0564	pseudouridine synthase activity
HLG75_14890	COG0358	DNA primase activity
HLG75_14905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HLG75_14935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLG75_14965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLG75_14975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLG75_14975	COG0352	thiamine-phosphate diphosphorylase activity
HLG75_14975	COG0351	phosphomethylpyrimidine kinase
HLG75_14980	COG1652	LysM domain
HLG75_15005	COG1399	metal-binding, possibly nucleic acid-binding protein
HLG75_15010	COG3101	peptidyl-lysine hydroxylation
HLG75_15015	COG0009	L-threonylcarbamoyladenylate synthase
HLG75_15020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLG75_15025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLG75_15040	COG4106	trans-aconitate 2-methyltransferase activity
HLG75_15055	COG0596	Alpha beta hydrolase
HLG75_15055	COG2226	methyltransferase
HLG75_15055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG75_15060	COG1877	trehalose-phosphatase activity
HLG75_15065	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HLG75_15070	COG2223	nitrite transmembrane transporter activity
HLG75_15090	COG1196	nuclear chromosome segregation
HLG75_15100	COG0730	response to heat
HLG75_15115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLG75_15125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG75_15175	COG0489	protein tyrosine kinase activity
HLG75_15185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG75_15185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG75_15215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLG75_15220	COG2081	HI0933 family
HLG75_15230	COG0668	transmembrane transport
HLG75_15250	COG0583	DNA-binding transcription factor activity
HLG75_15275	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLG75_15280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG75_15310	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLG75_15345	COG2205	protein histidine kinase activity
HLG75_15350	COG0745	RESPONSE REGULATOR receiver
HLG75_15365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLG75_15410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLG75_15425	COG0583	DNA-binding transcription factor activity
HLG75_15445	COG1473	amidohydrolase
HLG75_15455	COG0583	DNA-binding transcription factor activity
HLG75_15470	COG0583	DNA-binding transcription factor activity
HLG75_15475	COG1053	succinate dehydrogenase
HLG75_15485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLG75_15490	COG2814	Major facilitator Superfamily
HLG75_15495	COG1960	acyl-CoA dehydrogenase activity
HLG75_15500	COG0583	DNA-binding transcription factor activity
HLG75_15505	COG1063	alcohol dehydrogenase
HLG75_15535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLG75_15540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLG75_15545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG75_15565	COG2132	Multicopper oxidase
HLG75_15575	COG0561	phosphatase activity
HLG75_15580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLG75_15605	COG1214	PFAM Peptidase M22, glycoprotease
HLG75_15645	COG2826	transposase and inactivated derivatives, IS30 family
HLG75_15655	COG3328	transposase activity
HLG75_15660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLG75_15670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLG75_15675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLG75_15680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLG75_15740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLG75_15750	COG1846	Transcriptional regulator
HLG75_15755	COG1764	response to oxidative stress
HLG75_15795	COG0037	tRNA processing
HLG75_15805	COG0248	Ppx GppA phosphatase
HLG75_15835	COG0072	phenylalanine-tRNA ligase activity
HLG75_15875	COG1238	metal cluster binding
HLG75_15880	COG0625	glutathione transferase activity
HLG75_15895	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_15900	COG3028	Belongs to the UPF0307 family
HLG75_15905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLG75_15925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLG75_15930	COG0617	tRNA 3'-terminal CCA addition
HLG75_15935	COG1555	photosystem II stabilization
HLG75_15940	COG3956	TIGRFAM MazG family protein
HLG75_15950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLG75_15970	COG0784	Response regulator, receiver
HLG75_15970	COG5002	protein histidine kinase activity
HLG75_15970	COG2205	protein histidine kinase activity
HLG75_15975	COG1024	Enoyl-CoA hydratase
HLG75_15980	COG2084	Dehydrogenase
HLG75_15985	COG3622	Belongs to the hyi family
HLG75_16015	COG0697	spore germination
HLG75_16025	COG2814	Major facilitator Superfamily
HLG75_16030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLG75_16040	COG0583	DNA-binding transcription factor activity
HLG75_16050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLG75_16060	COG0084	hydrolase, TatD family'
HLG75_16075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLG75_16095	COG3501	Rhs element vgr protein
HLG75_16125	COG0440	acetolactate synthase activity
HLG75_16130	COG0028	Belongs to the TPP enzyme family
HLG75_16155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLG75_16160	COG1136	(ABC) transporter
HLG75_16160	COG0577	efflux transmembrane transporter activity
HLG75_16165	COG1538	Outer membrane efflux protein
HLG75_16180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HLG75_16185	COG1162	GTPase activity
HLG75_16195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLG75_16215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLG75_16220	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_16260	COG2986	histidine ammonia-lyase
HLG75_16270	COG1216	Glycosyl transferase, family 2
HLG75_16275	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_16285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLG75_16330	COG1426	Protein conserved in bacteria
HLG75_16365	COG0793	Belongs to the peptidase S41A family
HLG75_16380	COG2267	carboxylic ester hydrolase activity
HLG75_16390	COG1012	belongs to the aldehyde dehydrogenase family
HLG75_16395	COG3265	gluconokinase activity
HLG75_16405	COG0800	Aldolase
HLG75_16415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLG75_16420	COG0857	belongs to the CobB CobQ family
HLG75_16420	COG0280	phosphate acetyltransferase
HLG75_16425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG75_16425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLG75_16445	COG0740	serine-type endopeptidase activity
HLG75_16455	COG4774	siderophore transport
HLG75_16465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLG75_16475	COG2813	Specifically methylates the guanine in position
HLG75_16475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLG75_16620	COG0788	formyltetrahydrofolate deformylase activity
HLG75_16645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLG75_16645	COG4651	solute:proton antiporter activity
HLG75_16665	COG0724	RNA recognition motif
HLG75_16670	COG0210	DNA helicase
HLG75_16695	COG1733	regulation of RNA biosynthetic process
HLG75_16705	COG2900	Belongs to the SlyX family
HLG75_16715	COG1280	lysine exporter protein (LysE YggA)
HLG75_16720	COG1560	Kdo2-lipid A biosynthetic process
HLG75_16730	COG1301	dicarboxylic acid transport
HLG75_16785	COG0473	3-isopropylmalate dehydrogenase activity
HLG75_16840	COG0583	DNA-binding transcription factor activity
HLG75_16850	COG0625	glutathione transferase activity
HLG75_16855	COG2378	regulation of single-species biofilm formation
HLG75_16860	COG0546	phosphoglycolate phosphatase activity
HLG75_16875	COG1530	ribonuclease E activity
HLG75_16880	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_16895	COG0583	DNA-binding transcription factor activity
HLG75_16900	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_16905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLG75_16915	COG0534	Mate efflux family protein
HLG75_16930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLG75_16965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HLG75_16970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLG75_16985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLG75_16995	COG0644	oxidoreductase
HLG75_16995	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HLG75_17005	COG0425	Belongs to the sulfur carrier protein TusA family
HLG75_17010	COG4535	Mg2 and Co2 transporter CorC
HLG75_17020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLG75_17040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLG75_17045	COG0475	glutathione-regulated potassium exporter activity
HLG75_17045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLG75_17060	COG0484	heat shock protein binding
HLG75_17065	COG0789	Transcriptional regulator
HLG75_17070	COG0598	Magnesium transport protein CorA
HLG75_17090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLG75_17095	COG1074	ATP-dependent DNA helicase activity
HLG75_17100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HLG75_17120	COG2226	methyltransferase
HLG75_17135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLG75_17140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLG75_17155	COG2111	Na H antiporter
HLG75_17155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLG75_17160	COG1006	Multisubunit Na H antiporter MnhC subunit
HLG75_17165	COG0651	ATP synthesis coupled electron transport
HLG75_17175	COG2212	antiporter activity
HLG75_17195	COG0195	Participates in both transcription termination and antitermination
HLG75_17245	COG0237	dephospho-CoA kinase activity
HLG75_17255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLG75_17270	COG0497	DNA recombination
HLG75_17280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HLG75_17310	COG2169	Transcriptional regulator
HLG75_17310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLG75_17315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLG75_17375	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLG75_17390	COG0326	Molecular chaperone. Has ATPase activity
HLG75_17405	COG2056	Na+-H+ antiporter family
HLG75_17410	COG0596	Alpha beta hydrolase
HLG75_17505	COG0546	phosphoglycolate phosphatase activity
HLG75_17510	COG1716	ATPase activity
HLG75_17555	COG0181	hydroxymethylbilane synthase activity
HLG75_17565	COG3275	phosphorelay sensor kinase activity
HLG75_17585	COG1538	Outer membrane efflux protein
HLG75_17590	COG0697	spore germination
HLG75_17615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLG75_17620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLG75_17625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLG75_17630	COG0772	Belongs to the SEDS family
HLG75_17655	COG4974	Belongs to the 'phage' integrase family
HLG75_17660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG75_17670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLG75_17680	COG2197	response regulator
HLG75_17695	COG0793	Belongs to the peptidase S41A family
HLG75_17700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLG75_17705	COG0795	lipopolysaccharide-transporting ATPase activity
HLG75_17745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLG75_17745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLG75_17755	COG0004	ammonium transporteR
HLG75_17760	COG0347	Belongs to the P(II) protein family
HLG75_17770	COG0606	chelatase, subunit chli
HLG75_17775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLG75_17785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLG75_17800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLG75_17815	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_17825	COG0477	Major facilitator Superfamily
HLG75_17830	COG2860	membrane
HLG75_17835	COG3012	SEC-C Motif Domain Protein
HLG75_17840	COG1253	flavin adenine dinucleotide binding
HLG75_17850	COG0477	Major facilitator Superfamily
HLG75_17860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLG75_17895	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLG75_17905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLG75_17940	COG1309	transcriptional regulator
HLG75_17975	COG0758	DNA mediated transformation
HLG75_17985	COG0697	spore germination
HLG75_17990	COG1309	transcriptional regulator
HLG75_18005	COG0386	Belongs to the glutathione peroxidase family
HLG75_18075	COG1121	(ABC) transporter
HLG75_18080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLG75_18085	COG1280	lysine exporter protein (LysE YggA)
HLG75_18090	COG2837	iron assimilation
HLG75_18095	COG0281	malic enzyme
HLG75_18140	COG0519	Catalyzes the synthesis of GMP from XMP
HLG75_18140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLG75_18145	COG4399	Belongs to the UPF0754 family
HLG75_18150	COG2259	Doxx family
HLG75_18155	COG0586	Pfam SNARE associated Golgi protein
HLG75_18170	COG1192	Involved in chromosome partitioning
HLG75_18180	COG0271	Belongs to the BolA IbaG family
HLG75_18220	COG3321	synthase
HLG75_18220	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HLG75_18220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLG75_18220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLG75_18225	COG1960	acyl-CoA dehydrogenase activity
HLG75_18230	COG0318	PFAM AMP-dependent synthetase and ligase
HLG75_18235	COG2197	response regulator
HLG75_18245	COG3916	Acyl-homoserine-lactone synthase
HLG75_18250	COG0477	Major facilitator Superfamily
HLG75_18255	COG1024	Enoyl-CoA hydratase
HLG75_18260	COG1024	Enoyl-CoA hydratase
HLG75_18265	COG1960	acyl-CoA dehydrogenase activity
HLG75_18270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLG75_18290	COG1113	amino acid transport
HLG75_18295	COG1113	amino acid transport
HLG75_18300	COG0251	oxidation-reduction process
HLG75_18340	COG0564	pseudouridine synthase activity
HLG75_18420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLG75_18435	COG1802	Transcriptional regulator
HLG75_18445	COG1448	Aminotransferase
HLG75_18450	COG0277	FAD linked oxidase domain protein
HLG75_18460	COG2186	Transcriptional regulator
HLG75_18470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG75_18475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLG75_18490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLG75_18495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLG75_18520	COG0438	transferase activity, transferring glycosyl groups
HLG75_18550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLG75_18580	COG0728	peptidoglycan biosynthetic process
HLG75_18585	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLG75_18645	COG0546	phosphoglycolate phosphatase activity
HLG75_18650	COG1028	Short-chain dehydrogenase reductase Sdr
HLG75_18670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG75_18675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLG75_18680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLG75_18685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLG75_18690	COG1116	anion transmembrane transporter activity
HLG75_18695	COG1309	transcriptional regulator
HLG75_18700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLG75_18710	COG0196	riboflavin kinase activity
HLG75_18715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLG75_18725	COG1047	Peptidyl-prolyl cis-trans
HLG75_18765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLG75_18820	COG2951	lytic endotransglycosylase activity
HLG75_18825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLG75_18840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLG75_18850	COG0671	phosphoesterase, PA-phosphatase related
HLG75_18855	COG0861	Integral membrane protein TerC family
HLG75_18865	COG0754	glutathionylspermidine amidase activity
HLG75_18875	COG0402	S-adenosylhomocysteine deaminase activity
HLG75_18890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLG75_18895	COG1230	cation diffusion facilitator family transporter
HLG75_18910	COG0706	membrane insertase activity
HLG75_18945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLG75_19070	COG0739	heme binding
HLG75_19070	COG0741	lytic transglycosylase activity
HLG75_19070	COG1196	nuclear chromosome segregation
HLG75_19085	COG1196	nuclear chromosome segregation
HLG75_19085	COG0739	heme binding
HLG75_19085	COG0741	lytic transglycosylase activity
HLG75_19095	COG3451	type IV secretory pathway VirB4
HLG75_19110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLG75_19115	COG1846	Transcriptional regulator
HLG75_19120	COG1764	response to oxidative stress
HLG75_19135	COG0765	amino acid transport
HLG75_19190	COG1192	Involved in chromosome partitioning
HLG75_19215	COG4227	nucleotidyltransferase activity