locus-tag	class	description
E4K02_00105	COG3561	AntA/AntB antirepressor
E4K02_00225	COG0582	viral genome integration into host DNA
E4K02_00235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4K02_00255	COG0583	DNA-binding transcription factor activity
E4K02_00260	COG0473	3-isopropylmalate dehydrogenase activity
E4K02_00280	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_00300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E4K02_00300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4K02_00360	COG0456	acetyltransferase
E4K02_00370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E4K02_00375	COG0492	ferredoxin-NADP+ reductase activity
E4K02_00380	COG1674	ftsk spoiiie
E4K02_00380	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E4K02_00385	COG1280	lysine exporter protein (LysE YggA)
E4K02_00400	COG2894	cell division
E4K02_00415	COG0204	Acyl-transferase
E4K02_00420	COG2885	chlorophyll binding
E4K02_00425	COG0210	DNA helicase
E4K02_00435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4K02_00455	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_00470	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_00495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K02_00500	COG0735	belongs to the Fur family
E4K02_00525	COG0420	3'-5' exonuclease activity
E4K02_00545	COG1090	epimerase
E4K02_00560	COG2050	protein possibly involved in aromatic compounds catabolism
E4K02_00570	COG2814	Major facilitator Superfamily
E4K02_00575	COG0405	Gamma-glutamyltransferase
E4K02_00635	COG0477	Major facilitator Superfamily
E4K02_00640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4K02_00665	COG0531	amino acid
E4K02_00670	COG2040	homocysteine
E4K02_00695	COG1309	transcriptional regulator
E4K02_00700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4K02_00705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4K02_00715	COG1607	acyl-coa hydrolase
E4K02_00725	COG0523	cobalamin synthesis protein
E4K02_00735	COG4681	YaeQ
E4K02_00745	COG1649	PFAM Uncharacterised BCR, COG1649
E4K02_00745	COG0726	polysaccharide deacetylase
E4K02_00750	COG1215	transferase activity, transferring glycosyl groups
E4K02_00760	COG1024	Enoyl-CoA hydratase
E4K02_00775	COG1414	Transcriptional regulator
E4K02_00795	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_00805	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K02_00810	COG2271	Major facilitator Superfamily
E4K02_00820	COG2267	carboxylic ester hydrolase activity
E4K02_00825	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_00840	COG0028	Belongs to the TPP enzyme family
E4K02_00850	COG0477	Major facilitator Superfamily
E4K02_00855	COG0242	peptide deformylase activity
E4K02_00860	COG2066	Belongs to the glutaminase family
E4K02_00865	COG2207	Transcriptional regulator
E4K02_00870	COG2223	nitrite transmembrane transporter activity
E4K02_00895	COG0583	DNA-binding transcription factor activity
E4K02_00900	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_00905	COG2271	Major facilitator Superfamily
E4K02_00910	COG3959	Transketolase, thiamine diphosphate binding domain
E4K02_00915	COG3958	Transketolase
E4K02_00925	COG0306	phosphate transporter
E4K02_00945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4K02_00990	COG4181	ATPase activity
E4K02_00995	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E4K02_01025	COG0583	DNA-binding transcription factor activity
E4K02_01035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4K02_01040	COG1773	rubredoxin
E4K02_01090	COG2851	Citrate transporter
E4K02_01095	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_01105	COG1253	flavin adenine dinucleotide binding
E4K02_01145	COG0804	urea catabolic process
E4K02_01155	COG0830	nickel cation binding
E4K02_01170	COG0742	ribosomal rna small subunit methyltransferase
E4K02_01175	COG0768	penicillin binding
E4K02_01200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4K02_01205	COG2878	Part of a membrane complex involved in electron transport
E4K02_01210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4K02_01220	COG3384	dioxygenase
E4K02_01255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4K02_01530	COG2194	sulfuric ester hydrolase activity
E4K02_01560	COG0006	proline dipeptidase activity
E4K02_01565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K02_01570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K02_01590	COG1279	arginine transmembrane transporter activity
E4K02_01595	COG0583	DNA-binding transcription factor activity
E4K02_01650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4K02_01655	COG1388	LysM domain
E4K02_01655	COG0741	lytic transglycosylase activity
E4K02_01655	COG1388	LysM domain
E4K02_01655	COG0741	lytic transglycosylase activity
E4K02_01665	COG4174	ABC transporter (Permease)
E4K02_01670	COG4239	(ABC) transporter, permease
E4K02_01675	COG4172	Belongs to the ABC transporter superfamily
E4K02_01695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4K02_01705	COG5001	Diguanylate cyclase
E4K02_01705	COG3706	GGDEF domain
E4K02_01705	COG2203	Gaf domain
E4K02_01705	COG4251	negative regulation of phosphorylation
E4K02_01715	COG1902	pentaerythritol trinitrate reductase activity
E4K02_01715	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K02_01775	COG1113	amino acid transport
E4K02_01795	COG1960	acyl-CoA dehydrogenase activity
E4K02_01805	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_01810	COG1024	Enoyl-CoA hydratase
E4K02_01815	COG2814	Major facilitator Superfamily
E4K02_01830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K02_01875	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4K02_01880	COG2072	flavoprotein involved in K transport
E4K02_01885	COG0300	oxidoreductase activity
E4K02_01895	COG1309	transcriptional regulator
E4K02_01900	COG1741	Belongs to the pirin family
E4K02_01925	COG2072	flavoprotein involved in K transport
E4K02_01935	COG2252	PERMEase
E4K02_01940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4K02_01955	COG3038	cytochrome b561
E4K02_01965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E4K02_01985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4K02_02000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E4K02_02015	COG0667	Aldo Keto reductase
E4K02_02025	COG1765	OsmC-like protein
E4K02_02075	COG2885	chlorophyll binding
E4K02_02085	COG0625	glutathione transferase activity
E4K02_02090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E4K02_02110	COG3634	alkyl hydroperoxide reductase activity
E4K02_02120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4K02_02130	COG0450	alkyl hydroperoxide reductase
E4K02_02135	COG1643	Atp-dependent helicase
E4K02_02150	COG2814	Major facilitator Superfamily
E4K02_02155	COG3135	benzoate transporter
E4K02_02160	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_02165	COG0633	Ferredoxin
E4K02_02165	COG0543	2 iron, 2 sulfur cluster binding
E4K02_02170	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4K02_02175	COG4638	Rieske (2fe-2S)
E4K02_02180	COG0583	DNA-binding transcription factor activity
E4K02_02240	COG1570	exodeoxyribonuclease VII activity
E4K02_02275	COG1280	lysine exporter protein (LysE YggA)
E4K02_02280	COG1278	Cold shock
E4K02_02295	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_02320	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_02340	COG2814	Major facilitator Superfamily
E4K02_02345	COG1733	regulation of RNA biosynthetic process
E4K02_02360	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_02400	COG0517	IMP dehydrogenase activity
E4K02_02400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4K02_02405	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4K02_02415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E4K02_02420	COG1137	ATPase activity
E4K02_02425	COG1538	Outer membrane efflux protein
E4K02_02465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4K02_02480	COG1522	sequence-specific DNA binding
E4K02_02485	COG5006	permease, DMT superfamily
E4K02_02495	COG1560	Kdo2-lipid A biosynthetic process
E4K02_02510	COG2814	Major facilitator Superfamily
E4K02_02530	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K02_02560	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_02565	COG0583	DNA-binding transcription factor activity
E4K02_02570	COG1914	H( )-stimulated, divalent metal cation uptake system
E4K02_02590	COG4770	biotin carboxylase activity
E4K02_02595	COG0038	chloride channel
E4K02_02610	COG1309	transcriptional regulator
E4K02_02620	COG1063	alcohol dehydrogenase
E4K02_02635	COG0439	Biotin carboxylase
E4K02_02640	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4K02_02645	COG1733	regulation of RNA biosynthetic process
E4K02_02655	COG0864	Transcriptional regulator
E4K02_02670	COG1116	anion transmembrane transporter activity
E4K02_02700	COG0583	DNA-binding transcription factor activity
E4K02_02710	COG0590	tRNA wobble adenosine to inosine editing
E4K02_02725	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_02740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4K02_02745	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_02755	COG0789	Transcriptional regulator
E4K02_02770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4K02_02790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4K02_02815	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_02820	COG0531	amino acid
E4K02_02825	COG1760	l-serine dehydratase
E4K02_02830	COG2030	dehydratase
E4K02_02830	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_02835	COG3396	Phenylacetate-CoA oxygenase
E4K02_02840	COG3460	Phenylacetate-CoA oxygenase
E4K02_02845	COG3396	Phenylacetate-CoA oxygenase
E4K02_02850	COG2151	metal-sulfur cluster biosynthetic enzyme
E4K02_02855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K02_02860	COG1024	Enoyl-CoA hydratase
E4K02_02865	COG1024	Enoyl-CoA hydratase
E4K02_02870	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K02_02875	COG0183	Belongs to the thiolase family
E4K02_02880	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E4K02_02885	COG3327	negative regulation of DNA-templated transcription, initiation
E4K02_02895	COG2050	protein possibly involved in aromatic compounds catabolism
E4K02_02950	COG0753	catalase activity
E4K02_02955	COG3038	cytochrome b561
E4K02_02975	COG2267	carboxylic ester hydrolase activity
E4K02_02980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_02985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K02_02990	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_03000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4K02_03010	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_03015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4K02_03020	COG0583	DNA-binding transcription factor activity
E4K02_03030	COG1414	Transcriptional regulator
E4K02_03040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K02_03055	COG1840	ABC-type Fe3 transport system, periplasmic component
E4K02_03060	COG3842	ATPase activity
E4K02_03075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4K02_03080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4K02_03085	COG2814	Major facilitator Superfamily
E4K02_03090	COG1960	acyl-CoA dehydrogenase activity
E4K02_03105	COG1024	Enoyl-CoA hydratase
E4K02_03115	COG2814	Major facilitator Superfamily
E4K02_03125	COG0183	Belongs to the thiolase family
E4K02_03130	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4K02_03135	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_03140	COG1024	Enoyl-CoA hydratase
E4K02_03145	COG1960	acyl-CoA dehydrogenase activity
E4K02_03150	COG2814	Major facilitator Superfamily
E4K02_03155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4K02_03160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4K02_03170	COG2814	Major facilitator Superfamily
E4K02_03180	COG1960	acyl-CoA dehydrogenase activity
E4K02_03195	COG0583	DNA-binding transcription factor activity
E4K02_03210	COG1024	Enoyl-CoA hydratase
E4K02_03215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4K02_03220	COG1960	acyl-CoA dehydrogenase activity
E4K02_03225	COG1309	transcriptional regulator
E4K02_03230	COG0318	PFAM AMP-dependent synthetase and ligase
E4K02_03240	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_03265	COG0583	DNA-binding transcription factor activity
E4K02_03280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4K02_03330	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_03350	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_03375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E4K02_03395	COG2205	protein histidine kinase activity
E4K02_03395	COG0784	Response regulator, receiver
E4K02_03415	COG0765	amino acid transport
E4K02_03420	COG0765	amino acid transport
E4K02_03430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K02_03435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4K02_03455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4K02_03460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K02_03465	COG1045	serine acetyltransferase
E4K02_03475	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_03480	COG0583	DNA-binding transcription factor activity
E4K02_03485	COG0625	glutathione transferase activity
E4K02_03490	COG0625	glutathione transferase activity
E4K02_03495	COG0583	DNA-binding transcription factor activity
E4K02_03505	COG1346	cytolysis
E4K02_03525	COG2814	Major facilitator Superfamily
E4K02_03535	COG0583	DNA-binding transcription factor activity
E4K02_03545	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4K02_03550	COG3052	prosthetic group binding
E4K02_03570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4K02_03590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K02_03600	COG1294	oxidase, subunit
E4K02_03605	COG1271	oxidase subunit
E4K02_03630	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_03635	COG0477	Major facilitator Superfamily
E4K02_03645	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_03655	COG4521	taurine ABC transporter
E4K02_03660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4K02_03665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K02_03670	COG2175	clavaminate synthase activity
E4K02_03680	COG1953	Uracil, thiamine, allantoin
E4K02_03695	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_03710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E4K02_03725	COG0640	Transcriptional regulator
E4K02_03730	COG0798	PFAM Bile acid sodium symporter
E4K02_03735	COG0583	DNA-binding transcription factor activity
E4K02_03750	COG3634	alkyl hydroperoxide reductase activity
E4K02_03795	COG0436	Aminotransferase
E4K02_03805	COG0386	Belongs to the glutathione peroxidase family
E4K02_03845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4K02_03870	COG0012	GTP binding
E4K02_03875	COG2011	ABC-type metal ion transport system permease component
E4K02_03880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4K02_03890	COG1464	Belongs to the NlpA lipoprotein family
E4K02_03920	COG0765	amino acid transport
E4K02_03925	COG0765	amino acid transport
E4K02_03930	COG1126	abc transporter atp-binding protein
E4K02_03945	COG1522	sequence-specific DNA binding
E4K02_03965	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_04010	COG0583	DNA-binding transcription factor activity
E4K02_04020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4K02_04030	COG0697	spore germination
E4K02_04080	COG3539	Fimbrial protein
E4K02_04105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E4K02_04105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E4K02_04130	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_04155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4K02_04165	COG2353	YceI-like domain
E4K02_04185	COG3698	Phosphodiester glycosidase
E4K02_04200	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E4K02_04205	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4K02_04205	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4K02_04205	COG0506	proline dehydrogenase activity
E4K02_04215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4K02_04220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4K02_04240	COG1132	(ABC) transporter
E4K02_04245	COG3122	Protein conserved in bacteria
E4K02_04250	COG3619	membrane
E4K02_04260	COG0640	Transcriptional regulator
E4K02_04270	COG2850	peptidyl-arginine hydroxylation
E4K02_04275	COG0424	maF-like protein
E4K02_04295	COG0191	fructose-bisphosphate aldolase activity
E4K02_04300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K02_04315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4K02_04325	COG1192	Involved in chromosome partitioning
E4K02_04330	COG1475	DNA binding
E4K02_04335	COG0811	peptide transport
E4K02_04345	COG1132	(ABC) transporter
E4K02_04350	COG1663	tetraacyldisaccharide 4'-kinase activity
E4K02_04370	COG0084	hydrolase, TatD family'
E4K02_04385	COG2165	general secretion pathway protein
E4K02_04415	COG0590	tRNA wobble adenosine to inosine editing
E4K02_04435	COG0776	regulation of translation
E4K02_04465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4K02_04470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4K02_04495	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E4K02_04505	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_04520	COG0339	signal peptide processing
E4K02_04530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4K02_04565	COG0702	epimerase
E4K02_04570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4K02_04590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4K02_04620	COG0316	Belongs to the HesB IscA family
E4K02_04625	COG0822	iron-sulfur transferase activity
E4K02_04650	COG0776	regulation of translation
E4K02_04655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4K02_04660	COG2207	Transcriptional regulator
E4K02_04665	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4K02_04670	COG1960	acyl-CoA dehydrogenase activity
E4K02_04675	COG1960	acyl-CoA dehydrogenase activity
E4K02_04690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4K02_04710	COG4264	IucA IucC family
E4K02_04715	COG4264	IucA IucC family
E4K02_04725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4K02_04790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4K02_04795	COG0730	response to heat
E4K02_04815	COG4773	Receptor
E4K02_04820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4K02_04835	COG1131	(ABC) transporter
E4K02_04840	COG0842	Transport permease protein
E4K02_04845	COG0842	Transport permease protein
E4K02_04885	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_04915	COG2226	methyltransferase
E4K02_04940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E4K02_04975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4K02_04985	COG0133	tryptophan synthase activity
E4K02_05000	COG3706	GGDEF domain
E4K02_05015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4K02_05020	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_05030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E4K02_05035	COG0022	dehydrogenase e1 component
E4K02_05040	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K02_05045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K02_05055	COG1063	alcohol dehydrogenase
E4K02_05060	COG3781	membrane
E4K02_05070	COG3453	Protein conserved in bacteria
E4K02_05070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K02_05080	COG0730	response to heat
E4K02_05095	COG3708	Transcriptional regulator
E4K02_05095	COG2207	Transcriptional regulator
E4K02_05100	COG1733	regulation of RNA biosynthetic process
E4K02_05105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E4K02_05120	COG2081	HI0933 family
E4K02_05130	COG4521	taurine ABC transporter
E4K02_05135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K02_05155	COG0477	Major facilitator Superfamily
E4K02_05165	COG1027	Aspartate ammonia-lyase
E4K02_05180	COG0583	DNA-binding transcription factor activity
E4K02_05185	COG0583	DNA-binding transcription factor activity
E4K02_05190	COG0183	Belongs to the thiolase family
E4K02_05195	COG2031	fatty acid transporter
E4K02_05210	COG0583	DNA-binding transcription factor activity
E4K02_05220	COG2610	gluconate transmembrane transporter activity
E4K02_05225	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05230	COG2207	Transcriptional regulator
E4K02_05240	COG0412	Dienelactone hydrolase
E4K02_05245	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_05270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K02_05270	COG0543	2 iron, 2 sulfur cluster binding
E4K02_05275	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4K02_05280	COG4638	Rieske (2fe-2S)
E4K02_05290	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4K02_05295	COG4149	molybdate abc transporter
E4K02_05300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E4K02_05305	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05310	COG3433	isochorismatase activity
E4K02_05310	COG1535	isochorismatase
E4K02_05315	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_05380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4K02_05405	COG0753	catalase activity
E4K02_05415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4K02_05440	COG3539	Fimbrial protein
E4K02_05455	COG2801	Transposase and inactivated derivatives
E4K02_05485	COG0318	PFAM AMP-dependent synthetase and ligase
E4K02_05495	COG1960	acyl-CoA dehydrogenase activity
E4K02_05505	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05510	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05515	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05520	COG0583	DNA-binding transcription factor activity
E4K02_05525	COG1309	transcriptional regulator
E4K02_05550	COG0789	Transcriptional regulator
E4K02_05565	COG1902	pentaerythritol trinitrate reductase activity
E4K02_05565	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K02_05580	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_05600	COG2186	Transcriptional regulator
E4K02_05610	COG0583	DNA-binding transcription factor activity
E4K02_05615	COG4948	Mandelate Racemase Muconate Lactonizing
E4K02_05620	COG4829	muconolactone delta-isomerase
E4K02_05630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4K02_05635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4K02_05640	COG0183	Belongs to the thiolase family
E4K02_05645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K02_05650	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_05660	COG3733	amine oxidase
E4K02_05670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_05680	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_05690	COG4638	Rieske (2fe-2S)
E4K02_05710	COG0154	amidase activity
E4K02_05720	COG2814	Major facilitator Superfamily
E4K02_05760	COG1960	acyl-CoA dehydrogenase activity
E4K02_05765	COG0583	DNA-binding transcription factor activity
E4K02_05770	COG1414	Transcriptional regulator
E4K02_05785	COG2391	methyltransferase activity
E4K02_05795	COG4993	Dehydrogenase
E4K02_05800	COG3659	wide pore channel activity
E4K02_05805	COG3420	alginic acid biosynthetic process
E4K02_05825	COG3485	protocatechuate 3,4-dioxygenase
E4K02_05830	COG3485	protocatechuate 3,4-dioxygenase
E4K02_05835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4K02_05840	COG2271	Major facilitator Superfamily
E4K02_05845	COG0596	Alpha beta hydrolase
E4K02_05850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4K02_05855	COG0183	Belongs to the thiolase family
E4K02_05860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4K02_05865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E4K02_05875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4K02_05880	COG2323	membrane
E4K02_05945	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K02_05945	COG1902	pentaerythritol trinitrate reductase activity
E4K02_05960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4K02_05970	COG0542	response to heat
E4K02_05975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E4K02_06005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4K02_06010	COG0569	domain protein
E4K02_06015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E4K02_06030	COG4774	siderophore transport
E4K02_06035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4K02_06045	COG1585	Membrane protein implicated in regulation of membrane protease activity
E4K02_06065	COG1294	oxidase, subunit
E4K02_06070	COG4890	Cyd operon protein YbgT
E4K02_06085	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E4K02_06095	COG0552	protein localization to endoplasmic reticulum
E4K02_06125	COG0517	IMP dehydrogenase activity
E4K02_06125	COG0516	GMP reductase activity
E4K02_06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4K02_06135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4K02_06145	COG0583	DNA-binding transcription factor activity
E4K02_06150	COG0024	Methionine aminopeptidase
E4K02_06180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K02_06180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4K02_06185	COG1105	Belongs to the carbohydrate kinase PfkB family
E4K02_06190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E4K02_06190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4K02_06190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E4K02_06230	COG2135	peptidase activity
E4K02_06235	COG0659	secondary active sulfate transmembrane transporter activity
E4K02_06250	COG1113	amino acid transport
E4K02_06260	COG1522	sequence-specific DNA binding
E4K02_06290	COG1011	Hydrolase
E4K02_06295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E4K02_06305	COG2137	regulation of response to DNA damage stimulus
E4K02_06320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4K02_06340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4K02_06355	COG0575	Belongs to the CDS family
E4K02_06360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4K02_06385	COG3852	Histidine kinase
E4K02_06390	COG2204	response regulator
E4K02_06450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4K02_06455	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E4K02_06475	COG0697	spore germination
E4K02_06480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K02_06490	COG0303	'Molybdopterin
E4K02_06495	COG0315	cyclic pyranopterin monophosphate synthase activity
E4K02_06495	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4K02_06510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4K02_06515	COG0243	molybdopterin cofactor binding
E4K02_06525	COG0243	molybdopterin cofactor binding
E4K02_06530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4K02_06535	COG2146	nitrite reductase [NAD(P)H] activity
E4K02_06535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4K02_06545	COG0745	RESPONSE REGULATOR receiver
E4K02_06550	COG1116	anion transmembrane transporter activity
E4K02_06550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K02_06570	COG0511	ligase activity, forming carbon-carbon bonds
E4K02_06585	COG2814	Major facilitator Superfamily
E4K02_06600	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_06610	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_06890	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_06905	COG0069	glutamate synthase activity
E4K02_06925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4K02_06930	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_06940	COG1454	alcohol dehydrogenase
E4K02_06945	COG0824	Thioesterase
E4K02_06955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4K02_06985	COG0183	Belongs to the thiolase family
E4K02_06995	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_07005	COG0583	DNA-binding transcription factor activity
E4K02_07020	COG1522	sequence-specific DNA binding
E4K02_07025	COG3135	benzoate transporter
E4K02_07035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E4K02_07050	COG0589	response to stress
E4K02_07055	COG0488	(ABC) transporter
E4K02_07060	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_07080	COG4773	Receptor
E4K02_07095	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_07115	COG0668	transmembrane transport
E4K02_07125	COG1309	transcriptional regulator
E4K02_07135	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_07145	COG1605	Chorismate mutase
E4K02_07195	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_07200	COG0308	aminopeptidase N
E4K02_07220	COG2207	Transcriptional regulator
E4K02_07220	COG3708	Transcriptional regulator
E4K02_07230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4K02_07235	COG1454	alcohol dehydrogenase
E4K02_07255	COG0531	amino acid
E4K02_07260	COG4303	Ethanolamine ammonia lyase large subunit
E4K02_07265	COG4302	ethanolamine ammonia-lyase activity
E4K02_07270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K02_07270	COG0519	Catalyzes the synthesis of GMP from XMP
E4K02_07300	COG0697	spore germination
E4K02_07305	COG1923	regulation of RNA biosynthetic process
E4K02_07315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4K02_07320	COG0802	atpase or kinase
E4K02_07340	COG1187	pseudouridine synthase activity
E4K02_07355	COG0583	DNA-binding transcription factor activity
E4K02_07370	COG2814	Major facilitator Superfamily
E4K02_07375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4K02_07405	COG0729	surface antigen
E4K02_07425	COG0174	glutamine synthetase
E4K02_07430	COG0745	RESPONSE REGULATOR receiver
E4K02_07435	COG2205	protein histidine kinase activity
E4K02_07445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4K02_07450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4K02_07475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_07480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K02_07485	COG1960	acyl-CoA dehydrogenase activity
E4K02_07500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K02_07505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K02_07525	COG0583	DNA-binding transcription factor activity
E4K02_07545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K02_07555	COG3658	cytochrome
E4K02_07560	COG1215	transferase activity, transferring glycosyl groups
E4K02_07565	COG1649	PFAM Uncharacterised BCR, COG1649
E4K02_07565	COG0726	polysaccharide deacetylase
E4K02_07590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4K02_07595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4K02_07605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4K02_07630	COG0305	Participates in initiation and elongation during chromosome replication
E4K02_07635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E4K02_07645	COG1305	Transglutaminase-like
E4K02_07655	COG2308	Evidence 4 Homologs of previously reported genes of
E4K02_07685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4K02_07690	COG0138	bifunctional purine biosynthesis protein purh
E4K02_07695	COG0151	Belongs to the GarS family
E4K02_07700	COG1464	Belongs to the NlpA lipoprotein family
E4K02_07705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4K02_07710	COG2011	ABC-type metal ion transport system permease component
E4K02_07715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K02_07725	COG1301	dicarboxylic acid transport
E4K02_07755	COG1794	racemase activity, acting on amino acids and derivatives
E4K02_07760	COG0492	ferredoxin-NADP+ reductase activity
E4K02_07760	COG3118	belongs to the thioredoxin family
E4K02_07775	COG3008	intermembrane lipid transfer
E4K02_07775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4K02_07780	COG2995	paraquat-inducible protein a
E4K02_07805	COG0477	Major facilitator Superfamily
E4K02_07835	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_07865	COG2186	Transcriptional regulator
E4K02_07875	COG0786	glutamate:sodium symporter activity
E4K02_07880	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4K02_07915	COG3111	PFAM Bacterial OB fold (BOF) protein
E4K02_08010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E4K02_08015	COG1610	YqeY-like protein
E4K02_08020	COG4783	chaperone-mediated protein folding
E4K02_08045	COG1286	toxin biosynthetic process
E4K02_08075	COG0778	Nitroreductase
E4K02_08085	COG0513	Belongs to the DEAD box helicase family
E4K02_08105	COG2363	Small membrane protein
E4K02_08135	COG1234	tRNA 3'-trailer cleavage
E4K02_08140	COG2195	Cleaves the N-terminal amino acid of tripeptides
E4K02_08150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4K02_08165	COG1960	acyl-CoA dehydrogenase activity
E4K02_08170	COG1301	dicarboxylic acid transport
E4K02_08185	COG3139	Protein of unknown function (DUF1315)
E4K02_08190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4K02_08195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4K02_08205	COG0494	nUDIX hydrolase
E4K02_08215	COG0642	Histidine kinase
E4K02_08220	COG0745	RESPONSE REGULATOR receiver
E4K02_08240	COG1720	tRNA m6t6A37 methyltransferase activity
E4K02_08255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K02_08265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4K02_08280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K02_08290	COG1538	Outer membrane efflux protein
E4K02_08325	COG1131	(ABC) transporter
E4K02_08330	COG0842	Transport permease protein
E4K02_08345	COG0772	Belongs to the SEDS family
E4K02_08350	COG2951	lytic endotransglycosylase activity
E4K02_08375	COG2207	Transcriptional regulator
E4K02_08390	COG0052	Belongs to the universal ribosomal protein uS2 family
E4K02_08395	COG0024	Methionine aminopeptidase
E4K02_08405	COG2223	nitrite transmembrane transporter activity
E4K02_08415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K02_08420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4K02_08425	COG1960	acyl-CoA dehydrogenase activity
E4K02_08440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E4K02_08445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4K02_08450	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4K02_08470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K02_08475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4K02_08480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4K02_08515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E4K02_08530	COG3104	oligopeptide transport
E4K02_08545	COG1876	peptidase activity
E4K02_08560	COG0512	Glutamine amidotransferase of anthranilate synthase
E4K02_08565	COG0308	aminopeptidase N
E4K02_08595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4K02_08625	COG3739	integral membrane protein
E4K02_08650	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E4K02_08660	COG1132	(ABC) transporter
E4K02_08675	COG1535	isochorismatase
E4K02_08675	COG3433	isochorismatase activity
E4K02_08680	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4K02_08685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4K02_08695	COG4774	siderophore transport
E4K02_08700	COG4607	ABC-type enterochelin transport system periplasmic component
E4K02_08705	COG4604	ABC transporter, ATP-binding protein
E4K02_08710	COG4605	iron ion homeostasis
E4K02_08715	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4K02_08720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4K02_08725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4K02_08735	COG2964	Protein conserved in bacteria
E4K02_08745	COG1741	Belongs to the pirin family
E4K02_08775	COG2879	small protein
E4K02_08780	COG1966	Carbon starvation protein
E4K02_08800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E4K02_08825	COG1067	ATP-dependent peptidase activity
E4K02_08830	COG0583	DNA-binding transcription factor activity
E4K02_08855	COG1686	Belongs to the peptidase S11 family
E4K02_08860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E4K02_08895	COG0616	signal peptide processing
E4K02_08900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E4K02_08910	COG0573	inorganic phosphate transmembrane transporter activity
E4K02_08915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4K02_08920	COG1113	amino acid transport
E4K02_08925	COG3961	Belongs to the TPP enzyme family
E4K02_08930	COG1522	sequence-specific DNA binding
E4K02_08940	COG0076	glutamate decarboxylase activity
E4K02_08945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4K02_08960	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4K02_08970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K02_09005	COG0352	thiamine-phosphate diphosphorylase activity
E4K02_09030	COG0612	Peptidase, M16
E4K02_09045	COG0583	DNA-binding transcription factor activity
E4K02_09050	COG0477	Major facilitator Superfamily
E4K02_09075	COG1187	pseudouridine synthase activity
E4K02_09090	COG1686	Belongs to the peptidase S11 family
E4K02_09095	COG1252	NADH dehydrogenase
E4K02_09105	COG0415	Belongs to the DNA photolyase family
E4K02_09120	COG1215	transferase activity, transferring glycosyl groups
E4K02_09150	COG2070	2-Nitropropane dioxygenase
E4K02_09205	COG0556	nucleotide-excision repair
E4K02_09255	COG4221	oxidoreductase activity
E4K02_09265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E4K02_09270	COG1381	Involved in DNA repair and RecF pathway recombination
E4K02_09280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4K02_09295	COG0681	Belongs to the peptidase S26 family
E4K02_09310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K02_09330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4K02_09335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E4K02_09340	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4K02_09350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4K02_09355	COG4208	sulfate ABC transporter
E4K02_09360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4K02_09365	COG0583	DNA-binding transcription factor activity
E4K02_09370	COG4625	pathogenesis
E4K02_09385	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E4K02_09400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4K02_09410	COG1051	belongs to the nudix hydrolase family
E4K02_09410	COG1056	cytidyltransferase-related domain
E4K02_09415	COG1024	Enoyl-CoA hydratase
E4K02_09420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4K02_09425	COG2814	Major facilitator Superfamily
E4K02_09430	COG0047	phosphoribosylformylglycinamidine synthase activity
E4K02_09430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4K02_09450	COG1473	amidohydrolase
E4K02_09455	COG0824	Thioesterase
E4K02_09475	COG0823	Involved in the tonB-independent uptake of proteins
E4K02_09495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K02_09530	COG0628	permease
E4K02_09540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4K02_09545	COG0596	Alpha beta hydrolase
E4K02_09550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E4K02_09550	COG0616	signal peptide processing
E4K02_09560	COG0658	competence protein
E4K02_09560	COG2333	competence protein COMEC
E4K02_09565	COG1136	(ABC) transporter
E4K02_09570	COG4591	ABC-type transport system involved in lipoprotein release permease component
E4K02_09600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K02_09620	COG0463	Glycosyl transferase, family 2
E4K02_09650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4K02_09655	COG1280	lysine exporter protein (LysE YggA)
E4K02_09665	COG0019	diaminopimelate decarboxylase activity
E4K02_09675	COG1113	amino acid transport
E4K02_09690	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E4K02_09700	COG3339	Conserved Protein
E4K02_09710	COG0243	molybdopterin cofactor binding
E4K02_09715	COG1929	Belongs to the glycerate kinase type-1 family
E4K02_09730	COG0778	Nitroreductase
E4K02_09750	COG3811	Belongs to the UPF0386 family
E4K02_09775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4K02_09790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4K02_09815	COG0741	lytic transglycosylase activity
E4K02_09835	COG0584	glycerophosphoryl diester phosphodiesterase
E4K02_09840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K02_09860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4K02_09880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4K02_09885	COG0477	Major facilitator Superfamily
E4K02_09935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4K02_09940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4K02_09965	COG0505	Belongs to the CarA family
E4K02_09980	COG1309	transcriptional regulator
E4K02_09985	COG0251	oxidation-reduction process
E4K02_09995	COG0589	response to stress
E4K02_10010	COG2843	Capsule synthesis protein
E4K02_10050	COG2321	neutral zinc metallopeptidase
E4K02_10055	COG2354	Protein conserved in bacteria
E4K02_10075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4K02_10100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4K02_10105	COG1053	succinate dehydrogenase
E4K02_10110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E4K02_10115	COG2009	succinate dehydrogenase
E4K02_10150	COG2921	Belongs to the UPF0250 family
E4K02_10155	COG0321	lipoyl(octanoyl) transferase activity
E4K02_10170	COG0531	amino acid
E4K02_10180	COG1733	regulation of RNA biosynthetic process
E4K02_10185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E4K02_10190	COG1648	precorrin-2 dehydrogenase activity
E4K02_10190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4K02_10205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4K02_10235	COG0671	phosphoesterase, PA-phosphatase related
E4K02_10240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K02_10250	COG1538	Outer membrane efflux protein
E4K02_10265	COG2433	Pfam Transposase IS66
E4K02_10270	COG0393	Putative heavy-metal-binding
E4K02_10275	COG0393	Putative heavy-metal-binding
E4K02_10285	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_10295	COG0525	valine-tRNA ligase activity
E4K02_10310	COG0004	ammonium transporteR
E4K02_10320	COG0642	Histidine kinase
E4K02_10325	COG0745	RESPONSE REGULATOR receiver
E4K02_10330	COG2194	sulfuric ester hydrolase activity
E4K02_10350	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4K02_10365	COG2315	Protein conserved in bacteria
E4K02_10370	COG0142	geranyltranstransferase activity
E4K02_10375	COG2828	Protein conserved in bacteria
E4K02_10380	COG1113	amino acid transport
E4K02_10400	COG2207	Transcriptional regulator
E4K02_10425	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4K02_10445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4K02_10455	COG1530	ribonuclease E activity
E4K02_10460	COG0424	maF-like protein
E4K02_10465	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E4K02_10470	COG1792	Involved in formation and maintenance of cell shape
E4K02_10475	COG1077	Cell shape determining protein MreB Mrl
E4K02_10480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K02_10490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4K02_10515	COG3590	peptidase
E4K02_10520	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_10535	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E4K02_10540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4K02_10545	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4K02_10550	COG1115	amino acid carrier protein
E4K02_10570	COG2814	Major facilitator Superfamily
E4K02_10575	COG1289	transmembrane transporter activity
E4K02_10625	COG1376	ErfK ybiS ycfS ynhG family protein
E4K02_10630	COG2832	Protein of unknown function (DUF454)
E4K02_10640	COG5510	response to toxic substance
E4K02_10660	COG0840	transmembrane signaling receptor activity
E4K02_10705	COG3422	double-strand break repair
E4K02_10710	COG2824	Alkylphosphonate utilization operon protein PhnA
E4K02_10715	COG3189	MarR family transcriptional regulator
E4K02_10720	COG0596	Alpha beta hydrolase
E4K02_10725	COG0778	Nitroreductase
E4K02_10730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K02_10735	COG1335	isochorismatase
E4K02_10740	COG0251	oxidation-reduction process
E4K02_10745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_10750	COG2233	PERMEase
E4K02_10765	COG0354	folic acid binding
E4K02_10770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4K02_10780	COG0679	Auxin Efflux Carrier
E4K02_10785	COG1902	pentaerythritol trinitrate reductase activity
E4K02_10790	COG4772	TonB-dependent receptor
E4K02_10795	COG2094	Belongs to the DNA glycosylase MPG family
E4K02_10825	COG2233	PERMEase
E4K02_10835	COG0833	amino acid
E4K02_10840	COG1690	Belongs to the RtcB family
E4K02_10845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4K02_10845	COG2885	chlorophyll binding
E4K02_10855	COG0183	Belongs to the thiolase family
E4K02_10875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4K02_10895	COG2207	Transcriptional regulator
E4K02_10900	COG0183	Belongs to the thiolase family
E4K02_10930	COG1272	protein, Hemolysin III
E4K02_10950	COG0450	alkyl hydroperoxide reductase
E4K02_10970	COG0285	dihydrofolate synthase activity
E4K02_11005	COG0133	tryptophan synthase activity
E4K02_11020	COG2096	Adenosyltransferase
E4K02_11040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E4K02_11045	COG0745	RESPONSE REGULATOR receiver
E4K02_11050	COG2205	protein histidine kinase activity
E4K02_11060	COG1960	acyl-CoA dehydrogenase activity
E4K02_11065	COG1960	acyl-CoA dehydrogenase activity
E4K02_11115	COG1215	transferase activity, transferring glycosyl groups
E4K02_11130	COG1091	dTDP-4-dehydrorhamnose reductase activity
E4K02_11145	COG0438	transferase activity, transferring glycosyl groups
E4K02_11150	COG0726	polysaccharide deacetylase
E4K02_11165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4K02_11170	COG2205	protein histidine kinase activity
E4K02_11205	COG1862	Preprotein translocase
E4K02_11215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4K02_11230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E4K02_11240	COG3781	membrane
E4K02_11245	COG0613	PHP domain protein
E4K02_11255	COG2350	Protein conserved in bacteria
E4K02_11285	COG1607	acyl-coa hydrolase
E4K02_11300	COG3453	Protein conserved in bacteria
E4K02_11300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K02_11345	COG2199	diguanylate cyclase activity
E4K02_11355	COG1408	metallophosphoesterase
E4K02_11360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4K02_11370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4K02_11400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4K02_11405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4K02_11410	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4K02_11420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E4K02_11430	COG2969	positive regulation of protein catabolic process
E4K02_11450	COG1960	acyl-CoA dehydrogenase activity
E4K02_11455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4K02_11470	COG1309	transcriptional regulator
E4K02_11475	COG1960	acyl-CoA dehydrogenase activity
E4K02_11520	COG1183	phosphatidylcholine synthase activity
E4K02_11525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4K02_11555	COG0739	heme binding
E4K02_11555	COG1196	nuclear chromosome segregation
E4K02_11555	COG0741	lytic transglycosylase activity
E4K02_11565	COG1702	phosphate starvation-inducible protein PhoH
E4K02_11600	COG1295	ribonuclease BN
E4K02_11605	COG0697	spore germination
E4K02_11610	COG2169	Transcriptional regulator
E4K02_11615	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4K02_11635	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_11665	COG0557	exoribonuclease II activity
E4K02_11670	COG0339	signal peptide processing
E4K02_11675	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E4K02_11705	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4K02_11710	COG1960	acyl-CoA dehydrogenase activity
E4K02_11735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E4K02_11745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E4K02_11865	COG0626	cystathionine gamma-synthase activity
E4K02_11870	COG0433	COG0433 Predicted ATPase
E4K02_11880	COG1017	nitric oxide dioxygenase activity
E4K02_11880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K02_11885	COG1959	2 iron, 2 sulfur cluster binding
E4K02_11900	COG1301	dicarboxylic acid transport
E4K02_11905	COG1946	Acyl-CoA thioesterase
E4K02_11925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4K02_11930	COG1040	competence protein
E4K02_11935	COG0494	nUDIX hydrolase
E4K02_11945	COG0598	Magnesium transport protein CorA
E4K02_11955	COG2854	intermembrane phospholipid transfer
E4K02_11965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4K02_11970	COG1127	ABC transporter
E4K02_11980	COG0513	Belongs to the DEAD box helicase family
E4K02_12000	COG0408	coproporphyrinogen oxidase activity
E4K02_12015	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_12025	COG1960	acyl-CoA dehydrogenase activity
E4K02_12035	COG1983	PspC domain protein
E4K02_12040	COG0517	IMP dehydrogenase activity
E4K02_12085	COG0583	DNA-binding transcription factor activity
E4K02_12125	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_12135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4K02_12140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4K02_12145	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_12150	COG0833	amino acid
E4K02_12180	COG1192	Involved in chromosome partitioning
E4K02_12185	COG0628	permease
E4K02_12195	COG1289	transmembrane transporter activity
E4K02_12210	COG2249	NAD(P)H dehydrogenase (quinone) activity
E4K02_12215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E4K02_12225	COG0277	FAD linked oxidase domain protein
E4K02_12230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4K02_12255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4K02_12260	COG5380	lipid catabolic process
E4K02_12280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E4K02_12330	COG0194	GDP metabolic process
E4K02_12345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4K02_12365	COG3307	-O-antigen
E4K02_12390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4K02_12395	COG1704	LemA family
E4K02_12405	COG0493	'glutamate synthase
E4K02_12410	COG0070	glutamate synthase
E4K02_12410	COG0069	glutamate synthase activity
E4K02_12410	COG0067	glutamate synthase
E4K02_12470	COG2226	methyltransferase
E4K02_12485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4K02_12490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4K02_12535	COG0833	amino acid
E4K02_12555	COG0582	viral genome integration into host DNA
E4K02_12610	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_12615	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E4K02_12635	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_12750	COG0488	(ABC) transporter
E4K02_12760	COG4221	oxidoreductase activity
E4K02_12765	COG0659	secondary active sulfate transmembrane transporter activity
E4K02_12775	COG0745	RESPONSE REGULATOR receiver
E4K02_12790	COG0427	acetyl-CoA hydrolase
E4K02_12820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E4K02_12840	COG1132	(ABC) transporter
E4K02_12860	COG2329	Antibiotic biosynthesis monooxygenase
E4K02_12875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4K02_12930	COG0582	viral genome integration into host DNA
E4K02_12965	COG0305	Participates in initiation and elongation during chromosome replication
E4K02_13115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E4K02_13145	COG1335	isochorismatase
E4K02_13155	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_13160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4K02_13170	COG1113	amino acid transport
E4K02_13180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E4K02_13195	COG2814	Major facilitator Superfamily
E4K02_13205	COG0351	phosphomethylpyrimidine kinase
E4K02_13205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4K02_13205	COG0352	thiamine-phosphate diphosphorylase activity
E4K02_13225	COG1309	transcriptional regulator
E4K02_13230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4K02_13235	COG3706	GGDEF domain
E4K02_13245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4K02_13255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4K02_13260	COG3162	membrane
E4K02_13265	COG0784	Response regulator, receiver
E4K02_13265	COG2198	Histidine kinase
E4K02_13265	COG2205	protein histidine kinase activity
E4K02_13295	COG1335	isochorismatase
E4K02_13300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K02_13310	COG0668	transmembrane transport
E4K02_13315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4K02_13320	COG1519	Transferase
E4K02_13325	COG1902	pentaerythritol trinitrate reductase activity
E4K02_13350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4K02_13375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_13375	COG0426	domain, Protein
E4K02_13380	COG4774	siderophore transport
E4K02_13385	COG2119	membrane
E4K02_13395	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4K02_13405	COG4942	peptidase
E4K02_13420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E4K02_13430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4K02_13450	COG0189	ligase activity
E4K02_13475	COG2801	Transposase and inactivated derivatives
E4K02_13490	COG0708	Exodeoxyribonuclease III
E4K02_13495	COG1393	Belongs to the ArsC family
E4K02_13510	COG3706	GGDEF domain
E4K02_13545	COG2351	hydroxyisourate hydrolase activity
E4K02_13550	COG2233	PERMEase
E4K02_13560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K02_13570	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4K02_13580	COG3150	esterase
E4K02_13615	COG2918	glutathione biosynthetic process
E4K02_13630	COG2733	membrane
E4K02_13635	COG0436	Aminotransferase
E4K02_13640	COG0534	Mate efflux family protein
E4K02_13700	COG0753	catalase activity
E4K02_13750	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E4K02_13755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4K02_13765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4K02_13770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4K02_13775	COG0546	phosphoglycolate phosphatase activity
E4K02_13785	COG0010	Belongs to the arginase family
E4K02_13815	COG2188	Transcriptional regulator
E4K02_13825	COG0523	cobalamin synthesis protein
E4K02_13835	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_13840	COG1113	amino acid transport
E4K02_13850	COG0625	glutathione transferase activity
E4K02_13870	COG1683	Conserved Protein
E4K02_13875	COG0534	Mate efflux family protein
E4K02_13880	COG0385	Bile acid
E4K02_13885	COG1335	isochorismatase
E4K02_13890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4K02_13910	COG2116	formate transmembrane transporter activity
E4K02_13915	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4K02_13920	COG2133	pyrroloquinoline quinone binding
E4K02_13925	COG2983	Belongs to the UPF0260 family
E4K02_13945	COG1194	a g-specific adenine glycosylase
E4K02_13960	COG2818	Glycosylase
E4K02_13965	COG1064	alcohol dehydrogenase
E4K02_13970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K02_13985	COG0583	DNA-binding transcription factor activity
E4K02_13990	COG0656	L-ascorbic acid biosynthetic process
E4K02_13995	COG2814	Major facilitator Superfamily
E4K02_14030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K02_14045	COG2233	PERMEase
E4K02_14050	COG0583	DNA-binding transcription factor activity
E4K02_14085	COG0733	neurotransmitter:sodium symporter activity
E4K02_14130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4K02_14135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E4K02_14140	COG0596	Alpha beta hydrolase
E4K02_14165	COG0488	(ABC) transporter
E4K02_14170	COG0586	Pfam SNARE associated Golgi protein
E4K02_14180	COG0187	DNA topoisomerase II activity
E4K02_14190	COG0592	DNA-directed DNA polymerase activity
E4K02_14200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E4K02_14215	COG0706	membrane insertase activity
E4K02_14230	COG1230	cation diffusion facilitator family transporter
E4K02_14235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4K02_14250	COG0402	S-adenosylhomocysteine deaminase activity
E4K02_14260	COG0754	glutathionylspermidine amidase activity
E4K02_14270	COG0861	Integral membrane protein TerC family
E4K02_14275	COG0671	phosphoesterase, PA-phosphatase related
E4K02_14280	COG3328	transposase activity
E4K02_14290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4K02_14310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4K02_14315	COG2951	lytic endotransglycosylase activity
E4K02_14385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4K02_14425	COG1047	Peptidyl-prolyl cis-trans
E4K02_14435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4K02_14440	COG0196	riboflavin kinase activity
E4K02_14450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4K02_14455	COG1309	transcriptional regulator
E4K02_14460	COG1116	anion transmembrane transporter activity
E4K02_14465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4K02_14470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4K02_14475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K02_14480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4K02_14500	COG1028	Short-chain dehydrogenase reductase Sdr
E4K02_14505	COG0546	phosphoglycolate phosphatase activity
E4K02_14560	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4K02_14565	COG0728	peptidoglycan biosynthetic process
E4K02_14590	COG1596	polysaccharide export
E4K02_14595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E4K02_14605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4K02_14610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4K02_14615	COG2089	acid synthase
E4K02_14625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4K02_14630	COG1083	cytidylyl-transferase
E4K02_14665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E4K02_14680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4K02_14685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4K02_14690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4K02_14705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4K02_14710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E4K02_14720	COG2186	Transcriptional regulator
E4K02_14730	COG0277	FAD linked oxidase domain protein
E4K02_14735	COG1448	Aminotransferase
E4K02_14745	COG1802	Transcriptional regulator
E4K02_14760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4K02_14820	COG0564	pseudouridine synthase activity
E4K02_14855	COG1522	sequence-specific DNA binding
E4K02_14870	COG0251	oxidation-reduction process
E4K02_14875	COG1113	amino acid transport
E4K02_14880	COG1113	amino acid transport
E4K02_14900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4K02_14905	COG1960	acyl-CoA dehydrogenase activity
E4K02_14910	COG1024	Enoyl-CoA hydratase
E4K02_14915	COG1024	Enoyl-CoA hydratase
E4K02_14920	COG0477	Major facilitator Superfamily
E4K02_14925	COG3916	Acyl-homoserine-lactone synthase
E4K02_14955	COG0271	Belongs to the BolA IbaG family
E4K02_14965	COG1192	Involved in chromosome partitioning
E4K02_14980	COG0586	Pfam SNARE associated Golgi protein
E4K02_14985	COG2259	Doxx family
E4K02_14990	COG4399	Belongs to the UPF0754 family
E4K02_14995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4K02_14995	COG0519	Catalyzes the synthesis of GMP from XMP
E4K02_15045	COG0281	malic enzyme
E4K02_15050	COG2837	iron assimilation
E4K02_15055	COG1280	lysine exporter protein (LysE YggA)
E4K02_15060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4K02_15065	COG1121	(ABC) transporter
E4K02_15135	COG0386	Belongs to the glutathione peroxidase family
E4K02_15150	COG1309	transcriptional regulator
E4K02_15155	COG0697	spore germination
E4K02_15165	COG0758	DNA mediated transformation
E4K02_15200	COG1309	transcriptional regulator
E4K02_15235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4K02_15270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4K02_15280	COG0477	Major facilitator Superfamily
E4K02_15290	COG1253	flavin adenine dinucleotide binding
E4K02_15300	COG2860	membrane
E4K02_15305	COG0477	Major facilitator Superfamily
E4K02_15315	COG0318	PFAM AMP-dependent synthetase and ligase
E4K02_15330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4K02_15350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4K02_15355	COG0235	Class ii aldolase
E4K02_15360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4K02_15465	COG0789	Transcriptional regulator
E4K02_15475	COG0640	Transcriptional regulator
E4K02_15500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4K02_15530	COG0606	chelatase, subunit chli
E4K02_15540	COG0347	Belongs to the P(II) protein family
E4K02_15545	COG0004	ammonium transporteR
E4K02_15555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4K02_15555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4K02_15600	COG0795	lipopolysaccharide-transporting ATPase activity
E4K02_15605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E4K02_15610	COG0793	Belongs to the peptidase S41A family
E4K02_15625	COG2197	response regulator
E4K02_15635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E4K02_15645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4K02_15650	COG4974	Belongs to the 'phage' integrase family
E4K02_15675	COG0772	Belongs to the SEDS family
E4K02_15680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4K02_15685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E4K02_15690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4K02_15715	COG0697	spore germination
E4K02_15720	COG1538	Outer membrane efflux protein
E4K02_15740	COG3275	phosphorelay sensor kinase activity
E4K02_15750	COG0181	hydroxymethylbilane synthase activity
E4K02_15775	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_15805	COG1716	ATPase activity
E4K02_15810	COG0546	phosphoglycolate phosphatase activity
E4K02_15910	COG2056	Na+-H+ antiporter family
E4K02_15915	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_15930	COG0326	Molecular chaperone. Has ATPase activity
E4K02_15945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E4K02_16000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4K02_16005	COG2169	Transcriptional regulator
E4K02_16005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4K02_16035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E4K02_16045	COG0497	DNA recombination
E4K02_16060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4K02_16070	COG0237	dephospho-CoA kinase activity
E4K02_16120	COG0195	Participates in both transcription termination and antitermination
E4K02_16140	COG2212	antiporter activity
E4K02_16150	COG0651	ATP synthesis coupled electron transport
E4K02_16155	COG1006	Multisubunit Na H antiporter MnhC subunit
E4K02_16160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4K02_16160	COG2111	Na H antiporter
E4K02_16175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E4K02_16180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4K02_16195	COG2226	methyltransferase
E4K02_16215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4K02_16220	COG1074	ATP-dependent DNA helicase activity
E4K02_16225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4K02_16245	COG0598	Magnesium transport protein CorA
E4K02_16250	COG0789	Transcriptional regulator
E4K02_16255	COG0484	heat shock protein binding
E4K02_16270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4K02_16270	COG0475	glutathione-regulated potassium exporter activity
E4K02_16275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4K02_16295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K02_16305	COG4535	Mg2 and Co2 transporter CorC
E4K02_16310	COG0425	Belongs to the sulfur carrier protein TusA family
E4K02_16315	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E4K02_16315	COG0644	oxidoreductase
E4K02_16325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4K02_16340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4K02_16345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4K02_16385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E4K02_16400	COG0534	Mate efflux family protein
E4K02_16410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4K02_16415	COG4221	oxidoreductase activity
E4K02_16420	COG0583	DNA-binding transcription factor activity
E4K02_16440	COG1530	ribonuclease E activity
E4K02_16455	COG0546	phosphoglycolate phosphatase activity
E4K02_16460	COG2378	regulation of single-species biofilm formation
E4K02_16465	COG0625	glutathione transferase activity
E4K02_16475	COG0583	DNA-binding transcription factor activity
E4K02_16530	COG0473	3-isopropylmalate dehydrogenase activity
E4K02_16585	COG1301	dicarboxylic acid transport
E4K02_16595	COG1560	Kdo2-lipid A biosynthetic process
E4K02_16600	COG1280	lysine exporter protein (LysE YggA)
E4K02_16620	COG1733	regulation of RNA biosynthetic process
E4K02_16645	COG0210	DNA helicase
E4K02_16650	COG0724	RNA recognition motif
E4K02_16670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4K02_16670	COG4651	solute:proton antiporter activity
E4K02_16675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E4K02_16680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E4K02_16695	COG0788	formyltetrahydrofolate deformylase activity
E4K02_16795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K02_16795	COG2813	Specifically methylates the guanine in position
E4K02_16805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4K02_16815	COG4774	siderophore transport
E4K02_16825	COG0740	serine-type endopeptidase activity
E4K02_16845	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E4K02_16845	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E4K02_16850	COG0280	phosphate acetyltransferase
E4K02_16850	COG0857	belongs to the CobB CobQ family
E4K02_16855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4K02_16865	COG0800	Aldolase
E4K02_16875	COG3265	gluconokinase activity
E4K02_16880	COG1012	belongs to the aldehyde dehydrogenase family
E4K02_16890	COG2267	carboxylic ester hydrolase activity
E4K02_16905	COG0793	Belongs to the peptidase S41A family
E4K02_16940	COG1426	Protein conserved in bacteria
E4K02_16980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E4K02_16990	COG1162	GTPase activity
E4K02_16995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E4K02_17010	COG1538	Outer membrane efflux protein
E4K02_17015	COG0577	efflux transmembrane transporter activity
E4K02_17015	COG1136	(ABC) transporter
E4K02_17020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4K02_17045	COG0028	Belongs to the TPP enzyme family
E4K02_17050	COG0440	acetolactate synthase activity
E4K02_17090	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E4K02_17105	COG0084	hydrolase, TatD family'
E4K02_17115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4K02_17125	COG0583	DNA-binding transcription factor activity
E4K02_17135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4K02_17140	COG2814	Major facilitator Superfamily
E4K02_17150	COG0697	spore germination
E4K02_17155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4K02_17160	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E4K02_17165	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E4K02_17180	COG3622	Belongs to the hyi family
E4K02_17185	COG2084	Dehydrogenase
E4K02_17190	COG1024	Enoyl-CoA hydratase
E4K02_17195	COG0784	Response regulator, receiver
E4K02_17195	COG5002	protein histidine kinase activity
E4K02_17195	COG2205	protein histidine kinase activity
E4K02_17215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4K02_17225	COG3956	TIGRFAM MazG family protein
E4K02_17230	COG1555	photosystem II stabilization
E4K02_17235	COG0617	tRNA 3'-terminal CCA addition
E4K02_17240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4K02_17260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4K02_17265	COG3028	Belongs to the UPF0307 family
E4K02_17270	COG0318	PFAM AMP-dependent synthetase and ligase
E4K02_17285	COG0625	glutathione transferase activity
E4K02_17290	COG1238	metal cluster binding
E4K02_17305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E4K02_17330	COG0072	phenylalanine-tRNA ligase activity
E4K02_17360	COG0248	Ppx GppA phosphatase
E4K02_17370	COG0037	tRNA processing
E4K02_17410	COG1764	response to oxidative stress
E4K02_17415	COG1846	Transcriptional regulator
E4K02_17425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4K02_17485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4K02_17490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E4K02_17495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E4K02_17505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4K02_17520	COG3328	transposase activity
E4K02_17540	COG1214	PFAM Peptidase M22, glycoprotease
E4K02_17565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4K02_17570	COG0561	phosphatase activity
E4K02_17580	COG2132	Multicopper oxidase
E4K02_17585	COG3667	copper resistance
E4K02_17600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4K02_17605	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4K02_17610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E4K02_17640	COG1063	alcohol dehydrogenase
E4K02_17645	COG0583	DNA-binding transcription factor activity
E4K02_17650	COG1960	acyl-CoA dehydrogenase activity
E4K02_17655	COG2814	Major facilitator Superfamily
E4K02_17660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4K02_17665	COG1309	transcriptional regulator
E4K02_17680	COG1053	succinate dehydrogenase
E4K02_17685	COG0583	DNA-binding transcription factor activity
E4K02_17705	COG0583	DNA-binding transcription factor activity
E4K02_17715	COG0583	DNA-binding transcription factor activity
E4K02_17725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E4K02_17730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4K02_17750	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E4K02_17770	COG0745	RESPONSE REGULATOR receiver
E4K02_17775	COG2205	protein histidine kinase activity
E4K02_17785	COG3706	GGDEF domain
E4K02_17810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E4K02_17840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E4K02_17845	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E4K02_17865	COG0583	DNA-binding transcription factor activity
E4K02_17885	COG0668	transmembrane transport
E4K02_17895	COG2081	HI0933 family
E4K02_17900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E4K02_17930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K02_17930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E4K02_17940	COG0489	protein tyrosine kinase activity
E4K02_18000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4K02_18010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4K02_18025	COG0730	response to heat
E4K02_18035	COG1196	nuclear chromosome segregation
E4K02_18055	COG2223	nitrite transmembrane transporter activity
E4K02_18060	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4K02_18065	COG1877	trehalose-phosphatase activity
E4K02_18070	COG0596	Alpha beta hydrolase
E4K02_18070	COG2226	methyltransferase
E4K02_18070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4K02_18085	COG4106	trans-aconitate 2-methyltransferase activity
E4K02_18100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4K02_18105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4K02_18110	COG0009	L-threonylcarbamoyladenylate synthase
E4K02_18115	COG3101	peptidyl-lysine hydroxylation
E4K02_18120	COG1399	metal-binding, possibly nucleic acid-binding protein
E4K02_18145	COG1652	LysM domain
E4K02_18150	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E4K02_18150	COG0351	phosphomethylpyrimidine kinase
E4K02_18150	COG0352	thiamine-phosphate diphosphorylase activity
E4K02_18160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4K02_18170	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_18200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4K02_18230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4K02_18245	COG0358	DNA primase activity
E4K02_18255	COG0564	pseudouridine synthase activity
E4K02_18455	COG2076	Multidrug Resistance protein
E4K02_18465	COG0347	Belongs to the P(II) protein family
E4K02_18470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K02_18480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4K02_18500	COG2197	response regulator
E4K02_18505	COG3850	Histidine kinase
E4K02_18510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K02_18535	COG1475	DNA binding
E4K02_18540	COG1192	Involved in chromosome partitioning
E4K02_18595	COG4680	protein conserved in bacteria
E4K02_18600	COG3316	Transposase and inactivated derivatives
E4K02_18605	COG1373	ATPase (AAA superfamily
E4K02_18610	COG3316	Transposase and inactivated derivatives
E4K02_18615	COG3604	Transcriptional regulator
E4K02_18630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E4K02_18640	COG2144	transferase activity, transferring acyl groups
E4K02_18650	COG2072	flavoprotein involved in K transport
E4K02_18665	COG2801	Transposase and inactivated derivatives
E4K02_18670	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E4K02_18735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4K02_18820	COG0542	response to heat
E4K02_18825	COG0071	Belongs to the small heat shock protein (HSP20) family
E4K02_18845	COG0697	spore germination
E4K02_18860	COG2130	NADP-dependent
E4K02_18865	COG1309	transcriptional regulator
E4K02_18875	COG1902	pentaerythritol trinitrate reductase activity
E4K02_18885	COG1979	alcohol dehydrogenase
E4K02_18895	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4K02_18930	COG3316	Transposase and inactivated derivatives
E4K02_18940	COG1063	alcohol dehydrogenase
E4K02_18955	COG3335	DDE superfamily endonuclease
E4K02_18975	COG3328	transposase activity
E4K02_18980	COG2807	transmembrane transport
E4K02_18990	COG2826	transposase and inactivated derivatives, IS30 family
E4K02_19015	COG3657	addiction module killer protein
E4K02_19020	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4K02_19030	COG3657	addiction module killer protein
E4K02_19035	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4K02_19040	COG2169	Transcriptional regulator
E4K02_19040	COG1917	Cupin 2, conserved barrel domain protein
E4K02_19090	COG4221	oxidoreductase activity
E4K02_19095	COG0583	DNA-binding transcription factor activity
E4K02_19100	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E4K02_19105	COG3321	synthase
E4K02_19105	COG0604	alcohol dehydrogenase
E4K02_19125	COG0582	viral genome integration into host DNA
E4K02_19130	COG0069	glutamate synthase activity
E4K02_19135	COG2218	PFAM glutamate synthase alpha subunit domain protein
E4K02_19140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E4K02_19155	COG0004	ammonium transporteR
E4K02_19160	COG0004	ammonium transporteR
E4K02_19175	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4K02_19175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4K02_19185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4K02_19190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E4K02_19215	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E4K02_19250	COG2433	Pfam Transposase IS66
E4K02_19310	COG0697	spore germination
E4K02_19315	COG0477	Major facilitator Superfamily
E4K02_19355	COG3293	Transposase
E4K02_19390	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E4K02_19400	COG1192	Involved in chromosome partitioning
E4K02_19470	COG2026	Addiction module toxin, RelE StbE family
E4K02_19475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4K02_19480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair