locus-tag	class	description
IOMTU433_0004	COG0592	DNA-directed DNA polymerase activity
IOMTU433_0006	COG0187	DNA topoisomerase II activity
IOMTU433_0008	COG0586	Pfam SNARE associated Golgi protein
IOMTU433_0009	COG0488	(ABC) transporter
IOMTU433_0014	COG0596	Alpha beta hydrolase
IOMTU433_0015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IOMTU433_0016	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOMTU433_0025	COG0733	neurotransmitter:sodium symporter activity
IOMTU433_0027	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IOMTU433_0032	COG0583	DNA-binding transcription factor activity
IOMTU433_0033	COG2233	PERMEase
IOMTU433_0036	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_0043	COG2814	Major facilitator Superfamily
IOMTU433_0044	COG0583	DNA-binding transcription factor activity
IOMTU433_0045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_0046	COG1064	alcohol dehydrogenase
IOMTU433_0047	COG2818	Glycosylase
IOMTU433_0050	COG1194	a g-specific adenine glycosylase
IOMTU433_0052	COG0400	carboxylic ester hydrolase activity
IOMTU433_0054	COG2983	Belongs to the UPF0260 family
IOMTU433_0055	COG2133	pyrroloquinoline quinone binding
IOMTU433_0056	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOMTU433_0057	COG2116	formate transmembrane transporter activity
IOMTU433_0060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_0061	COG1335	isochorismatase
IOMTU433_0062	COG0385	Bile acid
IOMTU433_0063	COG0534	Mate efflux family protein
IOMTU433_0064	COG1683	Conserved Protein
IOMTU433_0067	COG0625	glutathione transferase activity
IOMTU433_0069	COG1113	amino acid transport
IOMTU433_0071	COG0523	cobalamin synthesis protein
IOMTU433_0073	COG2188	Transcriptional regulator
IOMTU433_0079	COG0010	Belongs to the arginase family
IOMTU433_0082	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOMTU433_0083	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOMTU433_0085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOMTU433_0087	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IOMTU433_0092	COG3830	Belongs to the UPF0237 family
IOMTU433_0092	COG0560	Phosphoserine phosphatase
IOMTU433_0096	COG0753	catalase activity
IOMTU433_0108	COG0534	Mate efflux family protein
IOMTU433_0109	COG0436	Aminotransferase
IOMTU433_0110	COG2733	membrane
IOMTU433_0113	COG2918	glutathione biosynthetic process
IOMTU433_0115	COG3501	Rhs element vgr protein
IOMTU433_0118	COG2826	transposase and inactivated derivatives, IS30 family
IOMTU433_0123	COG0673	inositol 2-dehydrogenase activity
IOMTU433_0127	COG2826	transposase and inactivated derivatives, IS30 family
IOMTU433_0128	COG1388	LysM domain
IOMTU433_0131	COG3150	esterase
IOMTU433_0134	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_0135	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IOMTU433_0137	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_0139	COG2233	PERMEase
IOMTU433_0140	COG2351	hydroxyisourate hydrolase activity
IOMTU433_0147	COG3706	GGDEF domain
IOMTU433_0150	COG1393	Belongs to the ArsC family
IOMTU433_0151	COG0708	Exodeoxyribonuclease III
IOMTU433_0155	COG0189	ligase activity
IOMTU433_0159	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IOMTU433_0161	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOMTU433_0164	COG4942	peptidase
IOMTU433_0166	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOMTU433_0168	COG2119	membrane
IOMTU433_0169	COG4774	siderophore transport
IOMTU433_0170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_0170	COG0426	domain, Protein
IOMTU433_0175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOMTU433_0180	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_0181	COG1519	Transferase
IOMTU433_0182	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOMTU433_0183	COG0668	transmembrane transport
IOMTU433_0185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOMTU433_0186	COG1335	isochorismatase
IOMTU433_0187	COG1522	sequence-specific DNA binding
IOMTU433_0192	COG2198	Histidine kinase
IOMTU433_0192	COG0784	Response regulator, receiver
IOMTU433_0192	COG2205	protein histidine kinase activity
IOMTU433_0193	COG3162	membrane
IOMTU433_0194	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOMTU433_0196	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOMTU433_0198	COG3706	GGDEF domain
IOMTU433_0200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOMTU433_0201	COG1309	transcriptional regulator
IOMTU433_0205	COG0351	phosphomethylpyrimidine kinase
IOMTU433_0205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOMTU433_0205	COG0352	thiamine-phosphate diphosphorylase activity
IOMTU433_0207	COG2814	Major facilitator Superfamily
IOMTU433_0210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOMTU433_0212	COG1113	amino acid transport
IOMTU433_0214	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOMTU433_0215	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_0217	COG1335	isochorismatase
IOMTU433_0224	COG2814	Major facilitator Superfamily
IOMTU433_0225	COG0583	DNA-binding transcription factor activity
IOMTU433_0229	COG0667	Aldo Keto reductase
IOMTU433_0236	COG1733	regulation of RNA biosynthetic process
IOMTU433_0237	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_0252	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IOMTU433_0255	COG2329	Antibiotic biosynthesis monooxygenase
IOMTU433_0261	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOMTU433_0267	COG0427	acetyl-CoA hydrolase
IOMTU433_0269	COG0745	RESPONSE REGULATOR receiver
IOMTU433_0271	COG0659	secondary active sulfate transmembrane transporter activity
IOMTU433_0272	COG4221	oxidoreductase activity
IOMTU433_0274	COG0488	(ABC) transporter
IOMTU433_0291	COG0833	amino acid
IOMTU433_0300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOMTU433_0301	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOMTU433_0304	COG2226	methyltransferase
IOMTU433_0314	COG0070	glutamate synthase
IOMTU433_0314	COG0069	glutamate synthase activity
IOMTU433_0314	COG0067	glutamate synthase
IOMTU433_0315	COG0493	'glutamate synthase
IOMTU433_0317	COG1704	LemA family
IOMTU433_0318	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IOMTU433_0321	COG3307	-O-antigen
IOMTU433_0325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOMTU433_0327	COG0194	GDP metabolic process
IOMTU433_0337	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOMTU433_0341	COG5380	lipid catabolic process
IOMTU433_0342	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOMTU433_0347	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOMTU433_0348	COG0277	FAD linked oxidase domain protein
IOMTU433_0350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IOMTU433_0351	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_0354	COG1289	transmembrane transporter activity
IOMTU433_0356	COG0628	permease
IOMTU433_0357	COG1192	Involved in chromosome partitioning
IOMTU433_0363	COG0833	amino acid
IOMTU433_0365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOMTU433_0366	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOMTU433_0368	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_0376	COG0583	DNA-binding transcription factor activity
IOMTU433_0386	COG0517	IMP dehydrogenase activity
IOMTU433_0387	COG1983	PspC domain protein
IOMTU433_0389	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_0392	COG0408	coproporphyrinogen oxidase activity
IOMTU433_0396	COG0513	Belongs to the DEAD box helicase family
IOMTU433_0398	COG1127	ABC transporter
IOMTU433_0399	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOMTU433_0401	COG2854	intermembrane phospholipid transfer
IOMTU433_0403	COG0598	Magnesium transport protein CorA
IOMTU433_0405	COG0494	nUDIX hydrolase
IOMTU433_0406	COG1040	competence protein
IOMTU433_0407	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOMTU433_0411	COG1946	Acyl-CoA thioesterase
IOMTU433_0412	COG1301	dicarboxylic acid transport
IOMTU433_0415	COG1959	2 iron, 2 sulfur cluster binding
IOMTU433_0416	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_0416	COG1017	nitric oxide dioxygenase activity
IOMTU433_0417	COG0433	COG0433 Predicted ATPase
IOMTU433_0418	COG0626	cystathionine gamma-synthase activity
IOMTU433_0442	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOMTU433_0444	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IOMTU433_0449	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_0450	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOMTU433_0456	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IOMTU433_0457	COG0339	signal peptide processing
IOMTU433_0458	COG0557	exoribonuclease II activity
IOMTU433_0469	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOMTU433_0470	COG2169	Transcriptional regulator
IOMTU433_0471	COG0697	spore germination
IOMTU433_0472	COG1295	ribonuclease BN
IOMTU433_0479	COG1702	phosphate starvation-inducible protein PhoH
IOMTU433_0481	COG1196	nuclear chromosome segregation
IOMTU433_0481	COG0741	lytic transglycosylase activity
IOMTU433_0481	COG0739	heme binding
IOMTU433_0487	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOMTU433_0488	COG1183	phosphatidylcholine synthase activity
IOMTU433_0497	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_0498	COG1309	transcriptional regulator
IOMTU433_0502	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOMTU433_0503	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_0511	COG2969	positive regulation of protein catabolic process
IOMTU433_0513	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IOMTU433_0516	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOMTU433_0517	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOMTU433_0521	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOMTU433_0523	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOMTU433_0524	COG1408	metallophosphoesterase
IOMTU433_0526	COG2199	diguanylate cyclase activity
IOMTU433_0535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOMTU433_0535	COG3453	Protein conserved in bacteria
IOMTU433_0538	COG1607	acyl-coa hydrolase
IOMTU433_0544	COG2350	Protein conserved in bacteria
IOMTU433_0546	COG0613	PHP domain protein
IOMTU433_0547	COG3781	membrane
IOMTU433_0549	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOMTU433_0551	COG2801	Transposase and inactivated derivatives
IOMTU433_0552	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOMTU433_0554	COG1862	Preprotein translocase
IOMTU433_0563	COG2205	protein histidine kinase activity
IOMTU433_0564	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IOMTU433_0567	COG0726	polysaccharide deacetylase
IOMTU433_0568	COG0438	transferase activity, transferring glycosyl groups
IOMTU433_0570	COG0438	transferase activity, transferring glycosyl groups
IOMTU433_0573	COG1442	glycosyl transferase family 8
IOMTU433_0584	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_0585	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_0587	COG2205	protein histidine kinase activity
IOMTU433_0588	COG0745	RESPONSE REGULATOR receiver
IOMTU433_0589	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IOMTU433_0593	COG2096	Adenosyltransferase
IOMTU433_0596	COG0133	tryptophan synthase activity
IOMTU433_0603	COG0285	dihydrofolate synthase activity
IOMTU433_0607	COG0450	alkyl hydroperoxide reductase
IOMTU433_0610	COG0477	Major facilitator Superfamily
IOMTU433_0611	COG1272	protein, Hemolysin III
IOMTU433_0613	COG2153	protein acetylation
IOMTU433_0617	COG0183	Belongs to the thiolase family
IOMTU433_0618	COG2207	Transcriptional regulator
IOMTU433_0623	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_0627	COG0183	Belongs to the thiolase family
IOMTU433_0629	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOMTU433_0629	COG2885	chlorophyll binding
IOMTU433_0631	COG1690	Belongs to the RtcB family
IOMTU433_0632	COG0833	amino acid
IOMTU433_0634	COG2233	PERMEase
IOMTU433_0640	COG2094	Belongs to the DNA glycosylase MPG family
IOMTU433_0641	COG4772	TonB-dependent receptor
IOMTU433_0642	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_0643	COG0679	Auxin Efflux Carrier
IOMTU433_0645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOMTU433_0646	COG0354	folic acid binding
IOMTU433_0648	COG3189	MarR family transcriptional regulator
IOMTU433_0649	COG2824	Alkylphosphonate utilization operon protein PhnA
IOMTU433_0650	COG3422	double-strand break repair
IOMTU433_0658	COG0840	transmembrane signaling receptor activity
IOMTU433_0662	COG5510	response to toxic substance
IOMTU433_0664	COG2832	Protein of unknown function (DUF454)
IOMTU433_0665	COG1376	ErfK ybiS ycfS ynhG family protein
IOMTU433_0675	COG1289	transmembrane transporter activity
IOMTU433_0676	COG2814	Major facilitator Superfamily
IOMTU433_0680	COG1115	amino acid carrier protein
IOMTU433_0681	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOMTU433_0682	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOMTU433_0683	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IOMTU433_0684	COG3590	peptidase
IOMTU433_0689	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOMTU433_0691	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOMTU433_0692	COG1077	Cell shape determining protein MreB Mrl
IOMTU433_0693	COG1792	Involved in formation and maintenance of cell shape
IOMTU433_0694	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOMTU433_0695	COG0424	maF-like protein
IOMTU433_0696	COG1530	ribonuclease E activity
IOMTU433_0698	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_0702	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_0709	COG2207	Transcriptional regulator
IOMTU433_0713	COG1113	amino acid transport
IOMTU433_0715	COG2828	Protein conserved in bacteria
IOMTU433_0716	COG0142	geranyltranstransferase activity
IOMTU433_0717	COG2315	Protein conserved in bacteria
IOMTU433_0720	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOMTU433_0724	COG2194	sulfuric ester hydrolase activity
IOMTU433_0725	COG0745	RESPONSE REGULATOR receiver
IOMTU433_0726	COG0642	Histidine kinase
IOMTU433_0728	COG0004	ammonium transporteR
IOMTU433_0729	COG0583	DNA-binding transcription factor activity
IOMTU433_0733	COG0525	valine-tRNA ligase activity
IOMTU433_0735	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_0737	COG0393	Putative heavy-metal-binding
IOMTU433_0738	COG0393	Putative heavy-metal-binding
IOMTU433_0739	COG1538	Outer membrane efflux protein
IOMTU433_0741	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_0742	COG0671	phosphoesterase, PA-phosphatase related
IOMTU433_0747	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IOMTU433_0750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IOMTU433_0750	COG1648	precorrin-2 dehydrogenase activity
IOMTU433_0751	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOMTU433_0752	COG1733	regulation of RNA biosynthetic process
IOMTU433_0754	COG0531	amino acid
IOMTU433_0757	COG0321	lipoyl(octanoyl) transferase activity
IOMTU433_0758	COG2921	Belongs to the UPF0250 family
IOMTU433_0766	COG2009	succinate dehydrogenase
IOMTU433_0767	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IOMTU433_0768	COG1053	succinate dehydrogenase
IOMTU433_0769	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOMTU433_0773	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOMTU433_0777	COG2354	Protein conserved in bacteria
IOMTU433_0778	COG2321	neutral zinc metallopeptidase
IOMTU433_0782	COG2843	Capsule synthesis protein
IOMTU433_0785	COG0589	response to stress
IOMTU433_0787	COG0251	oxidation-reduction process
IOMTU433_0788	COG1309	transcriptional regulator
IOMTU433_0791	COG0505	Belongs to the CarA family
IOMTU433_0796	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOMTU433_0797	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOMTU433_0807	COG0477	Major facilitator Superfamily
IOMTU433_0808	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOMTU433_0812	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOMTU433_0818	COG0584	glycerophosphoryl diester phosphodiesterase
IOMTU433_0822	COG0741	lytic transglycosylase activity
IOMTU433_0826	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOMTU433_0829	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_0831	COG3811	Belongs to the UPF0386 family
IOMTU433_0835	COG0778	Nitroreductase
IOMTU433_0838	COG1929	Belongs to the glycerate kinase type-1 family
IOMTU433_0839	COG0243	molybdopterin cofactor binding
IOMTU433_0840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOMTU433_0841	COG3339	Conserved Protein
IOMTU433_0843	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IOMTU433_0847	COG1113	amino acid transport
IOMTU433_0849	COG0019	diaminopimelate decarboxylase activity
IOMTU433_0851	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_0852	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IOMTU433_0858	COG0463	Glycosyl transferase, family 2
IOMTU433_0862	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_0869	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOMTU433_0870	COG1136	(ABC) transporter
IOMTU433_0871	COG2333	competence protein COMEC
IOMTU433_0871	COG0658	competence protein
IOMTU433_0873	COG0616	signal peptide processing
IOMTU433_0873	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOMTU433_0874	COG0596	Alpha beta hydrolase
IOMTU433_0875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IOMTU433_0877	COG0628	permease
IOMTU433_0884	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOMTU433_0888	COG0823	Involved in the tonB-independent uptake of proteins
IOMTU433_0892	COG0824	Thioesterase
IOMTU433_0893	COG1473	amidohydrolase
IOMTU433_0897	COG0047	phosphoribosylformylglycinamidine synthase activity
IOMTU433_0897	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOMTU433_0898	COG2814	Major facilitator Superfamily
IOMTU433_0899	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOMTU433_0900	COG1024	Enoyl-CoA hydratase
IOMTU433_0901	COG1056	cytidyltransferase-related domain
IOMTU433_0901	COG1051	belongs to the nudix hydrolase family
IOMTU433_0903	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOMTU433_0906	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IOMTU433_0909	COG4625	pathogenesis
IOMTU433_0910	COG0583	DNA-binding transcription factor activity
IOMTU433_0911	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOMTU433_0912	COG4208	sulfate ABC transporter
IOMTU433_0913	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IOMTU433_0916	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IOMTU433_0917	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOMTU433_0918	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOMTU433_0922	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOMTU433_0924	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOMTU433_0926	COG0681	Belongs to the peptidase S26 family
IOMTU433_0929	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOMTU433_0931	COG1381	Involved in DNA repair and RecF pathway recombination
IOMTU433_0932	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IOMTU433_0934	COG4221	oxidoreductase activity
IOMTU433_0939	COG0443	Heat shock 70 kDa protein
IOMTU433_0945	COG0556	nucleotide-excision repair
IOMTU433_0956	COG2070	2-Nitropropane dioxygenase
IOMTU433_0962	COG1215	transferase activity, transferring glycosyl groups
IOMTU433_0965	COG0415	Belongs to the DNA photolyase family
IOMTU433_0967	COG1252	NADH dehydrogenase
IOMTU433_0968	COG1686	Belongs to the peptidase S11 family
IOMTU433_0971	COG1187	pseudouridine synthase activity
IOMTU433_0985	COG3645	SOS response
IOMTU433_0985	COG3646	Phage regulatory protein
IOMTU433_1036	COG0582	viral genome integration into host DNA
IOMTU433_1040	COG0477	Major facilitator Superfamily
IOMTU433_1041	COG0583	DNA-binding transcription factor activity
IOMTU433_1044	COG0612	Peptidase, M16
IOMTU433_1049	COG0352	thiamine-phosphate diphosphorylase activity
IOMTU433_1056	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_1058	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_1061	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOMTU433_1062	COG0076	glutamate decarboxylase activity
IOMTU433_1064	COG1522	sequence-specific DNA binding
IOMTU433_1065	COG3961	Belongs to the TPP enzyme family
IOMTU433_1066	COG1113	amino acid transport
IOMTU433_1067	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOMTU433_1068	COG0573	inorganic phosphate transmembrane transporter activity
IOMTU433_1070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOMTU433_1071	COG0616	signal peptide processing
IOMTU433_1078	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOMTU433_1079	COG1686	Belongs to the peptidase S11 family
IOMTU433_1084	COG0583	DNA-binding transcription factor activity
IOMTU433_1085	COG1067	ATP-dependent peptidase activity
IOMTU433_1090	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IOMTU433_1094	COG1966	Carbon starvation protein
IOMTU433_1095	COG2879	small protein
IOMTU433_1103	COG1335	isochorismatase
IOMTU433_1104	COG0583	DNA-binding transcription factor activity
IOMTU433_1107	COG0596	Alpha beta hydrolase
IOMTU433_1109	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOMTU433_1111	COG2130	NADP-dependent
IOMTU433_1117	COG1741	Belongs to the pirin family
IOMTU433_1119	COG2964	Protein conserved in bacteria
IOMTU433_1122	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_1123	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOMTU433_1124	COG4605	iron ion homeostasis
IOMTU433_1125	COG4604	ABC transporter, ATP-binding protein
IOMTU433_1126	COG4607	ABC-type enterochelin transport system periplasmic component
IOMTU433_1127	COG4774	siderophore transport
IOMTU433_1129	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_1130	COG1021	2,3-dihydroxybenzoate-AMP ligase
IOMTU433_1131	COG3433	isochorismatase activity
IOMTU433_1131	COG1535	isochorismatase
IOMTU433_1136	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IOMTU433_1138	COG1169	isochorismate synthase
IOMTU433_1141	COG3739	integral membrane protein
IOMTU433_1147	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IOMTU433_1153	COG0308	aminopeptidase N
IOMTU433_1154	COG0512	Glutamine amidotransferase of anthranilate synthase
IOMTU433_1156	COG3104	oligopeptide transport
IOMTU433_1159	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOMTU433_1166	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOMTU433_1167	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOMTU433_1168	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOMTU433_1172	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOMTU433_1173	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IOMTU433_1174	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOMTU433_1177	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_1178	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOMTU433_1179	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOMTU433_1182	COG2223	nitrite transmembrane transporter activity
IOMTU433_1184	COG0024	Methionine aminopeptidase
IOMTU433_1185	COG0052	Belongs to the universal ribosomal protein uS2 family
IOMTU433_1188	COG2207	Transcriptional regulator
IOMTU433_1193	COG2951	lytic endotransglycosylase activity
IOMTU433_1194	COG0772	Belongs to the SEDS family
IOMTU433_1197	COG0842	Transport permease protein
IOMTU433_1198	COG1131	(ABC) transporter
IOMTU433_1204	COG1538	Outer membrane efflux protein
IOMTU433_1206	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_1209	COG4215	(ABC) transporter
IOMTU433_1210	COG4160	amino acid transport
IOMTU433_1211	COG4598	ABC transporter
IOMTU433_1213	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOMTU433_1215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_1218	COG1720	tRNA m6t6A37 methyltransferase activity
IOMTU433_1222	COG0745	RESPONSE REGULATOR receiver
IOMTU433_1223	COG0642	Histidine kinase
IOMTU433_1225	COG0494	nUDIX hydrolase
IOMTU433_1227	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOMTU433_1228	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOMTU433_1229	COG3139	Protein of unknown function (DUF1315)
IOMTU433_1230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOMTU433_1231	COG1301	dicarboxylic acid transport
IOMTU433_1232	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_1233	COG2819	hydrolase of the alpha beta superfamily
IOMTU433_1235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOMTU433_1237	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOMTU433_1238	COG1234	tRNA 3'-trailer cleavage
IOMTU433_1244	COG2363	Small membrane protein
IOMTU433_1248	COG0513	Belongs to the DEAD box helicase family
IOMTU433_1250	COG0778	Nitroreductase
IOMTU433_1261	COG4783	chaperone-mediated protein folding
IOMTU433_1262	COG1610	YqeY-like protein
IOMTU433_1263	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IOMTU433_1273	COG2831	hemolysin activation secretion protein
IOMTU433_1274	COG3210	domain, Protein
IOMTU433_1274	COG3210	domain, Protein
IOMTU433_1297	COG3111	PFAM Bacterial OB fold (BOF) protein
IOMTU433_1302	COG3243	poly(R)-hydroxyalkanoic acid synthase
IOMTU433_1303	COG0786	glutamate:sodium symporter activity
IOMTU433_1305	COG2186	Transcriptional regulator
IOMTU433_1315	COG0477	Major facilitator Superfamily
IOMTU433_1319	COG2985	domain, Protein
IOMTU433_1322	COG2995	paraquat-inducible protein a
IOMTU433_1323	COG3008	intermembrane lipid transfer
IOMTU433_1323	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOMTU433_1325	COG2351	hydroxyisourate hydrolase activity
IOMTU433_1333	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOMTU433_1335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOMTU433_1336	COG0642	Histidine kinase
IOMTU433_1337	COG0745	RESPONSE REGULATOR receiver
IOMTU433_1341	COG1794	racemase activity, acting on amino acids and derivatives
IOMTU433_1347	COG1301	dicarboxylic acid transport
IOMTU433_1350	COG2011	ABC-type metal ion transport system permease component
IOMTU433_1351	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOMTU433_1352	COG1464	Belongs to the NlpA lipoprotein family
IOMTU433_1353	COG0151	Belongs to the GarS family
IOMTU433_1354	COG0138	bifunctional purine biosynthesis protein purh
IOMTU433_1355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IOMTU433_1361	COG2308	Evidence 4 Homologs of previously reported genes of
IOMTU433_1363	COG1305	Transglutaminase-like
IOMTU433_1365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOMTU433_1366	COG0305	Participates in initiation and elongation during chromosome replication
IOMTU433_1371	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IOMTU433_1373	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOMTU433_1374	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOMTU433_1379	COG0726	polysaccharide deacetylase
IOMTU433_1379	COG1649	PFAM Uncharacterised BCR, COG1649
IOMTU433_1380	COG1215	transferase activity, transferring glycosyl groups
IOMTU433_1381	COG3658	cytochrome
IOMTU433_1383	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOMTU433_1386	COG0583	DNA-binding transcription factor activity
IOMTU433_1390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_1391	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_1394	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_1395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOMTU433_1396	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_1401	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IOMTU433_1402	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IOMTU433_1404	COG2205	protein histidine kinase activity
IOMTU433_1405	COG0745	RESPONSE REGULATOR receiver
IOMTU433_1406	COG0174	glutamine synthetase
IOMTU433_1410	COG0729	surface antigen
IOMTU433_1415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOMTU433_1416	COG2814	Major facilitator Superfamily
IOMTU433_1419	COG0583	DNA-binding transcription factor activity
IOMTU433_1422	COG1187	pseudouridine synthase activity
IOMTU433_1426	COG0802	atpase or kinase
IOMTU433_1427	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IOMTU433_1429	COG1923	regulation of RNA biosynthetic process
IOMTU433_1430	COG0697	spore germination
IOMTU433_1437	COG0519	Catalyzes the synthesis of GMP from XMP
IOMTU433_1437	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOMTU433_1438	COG4302	ethanolamine ammonia-lyase activity
IOMTU433_1439	COG4303	Ethanolamine ammonia lyase large subunit
IOMTU433_1440	COG0531	amino acid
IOMTU433_1444	COG1454	alcohol dehydrogenase
IOMTU433_1445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOMTU433_1450	COG0308	aminopeptidase N
IOMTU433_1456	COG4221	oxidoreductase activity
IOMTU433_1458	COG1605	Chorismate mutase
IOMTU433_1461	COG1309	transcriptional regulator
IOMTU433_1463	COG0668	transmembrane transport
IOMTU433_1469	COG4773	Receptor
IOMTU433_1473	COG0488	(ABC) transporter
IOMTU433_1474	COG0589	response to stress
IOMTU433_1478	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOMTU433_1480	COG3135	benzoate transporter
IOMTU433_1481	COG1522	sequence-specific DNA binding
IOMTU433_1484	COG0583	DNA-binding transcription factor activity
IOMTU433_1486	COG0183	Belongs to the thiolase family
IOMTU433_1492	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOMTU433_1494	COG0824	Thioesterase
IOMTU433_1495	COG1454	alcohol dehydrogenase
IOMTU433_1497	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOMTU433_1503	COG0069	glutamate synthase activity
IOMTU433_1520	COG3620	sequence-specific DNA binding
IOMTU433_1557	COG1598	PFAM Uncharacterised protein family UPF0150
IOMTU433_1559	COG0741	lytic transglycosylase activity
IOMTU433_1559	COG1196	nuclear chromosome segregation
IOMTU433_1559	COG0739	heme binding
IOMTU433_1566	COG3179	chitinase
IOMTU433_1568	COG1063	alcohol dehydrogenase
IOMTU433_1569	COG3293	Transposase
IOMTU433_1577	COG2814	Major facilitator Superfamily
IOMTU433_1580	COG0511	ligase activity, forming carbon-carbon bonds
IOMTU433_1583	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_1583	COG1116	anion transmembrane transporter activity
IOMTU433_1584	COG0745	RESPONSE REGULATOR receiver
IOMTU433_1586	COG2146	nitrite reductase [NAD(P)H] activity
IOMTU433_1586	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_1587	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_1588	COG0243	molybdopterin cofactor binding
IOMTU433_1590	COG0243	molybdopterin cofactor binding
IOMTU433_1591	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOMTU433_1594	COG0315	cyclic pyranopterin monophosphate synthase activity
IOMTU433_1594	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOMTU433_1597	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_1598	COG0697	spore germination
IOMTU433_1602	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOMTU433_1603	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOMTU433_1614	COG2204	response regulator
IOMTU433_1615	COG3852	Histidine kinase
IOMTU433_1620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOMTU433_1621	COG0575	Belongs to the CDS family
IOMTU433_1628	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOMTU433_1630	COG2137	regulation of response to DNA damage stimulus
IOMTU433_1632	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOMTU433_1633	COG1011	Hydrolase
IOMTU433_1638	COG1522	sequence-specific DNA binding
IOMTU433_1640	COG1113	amino acid transport
IOMTU433_1643	COG0659	secondary active sulfate transmembrane transporter activity
IOMTU433_1644	COG2135	peptidase activity
IOMTU433_1647	COG3300	MHYT domain
IOMTU433_1647	COG5001	Diguanylate cyclase
IOMTU433_1651	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOMTU433_1651	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOMTU433_1651	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOMTU433_1652	COG1105	Belongs to the carbohydrate kinase PfkB family
IOMTU433_1653	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOMTU433_1653	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOMTU433_1659	COG0024	Methionine aminopeptidase
IOMTU433_1660	COG0583	DNA-binding transcription factor activity
IOMTU433_1662	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOMTU433_1663	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOMTU433_1664	COG0516	GMP reductase activity
IOMTU433_1664	COG0517	IMP dehydrogenase activity
IOMTU433_1669	COG0552	protein localization to endoplasmic reticulum
IOMTU433_1671	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IOMTU433_1674	COG1294	oxidase, subunit
IOMTU433_1676	COG1585	Membrane protein implicated in regulation of membrane protease activity
IOMTU433_1678	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOMTU433_1679	COG4774	siderophore transport
IOMTU433_1682	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOMTU433_1683	COG0569	domain protein
IOMTU433_1684	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOMTU433_1691	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IOMTU433_1692	COG0542	response to heat
IOMTU433_1694	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOMTU433_1697	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_1697	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_1706	COG2323	membrane
IOMTU433_1707	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IOMTU433_1709	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOMTU433_1710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOMTU433_1711	COG0183	Belongs to the thiolase family
IOMTU433_1712	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOMTU433_1713	COG0596	Alpha beta hydrolase
IOMTU433_1714	COG2271	Major facilitator Superfamily
IOMTU433_1715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOMTU433_1716	COG3485	protocatechuate 3,4-dioxygenase
IOMTU433_1717	COG3485	protocatechuate 3,4-dioxygenase
IOMTU433_1718	COG0710	3-dehydroquinate dehydratase activity
IOMTU433_1719	COG3420	alginic acid biosynthetic process
IOMTU433_1720	COG3659	wide pore channel activity
IOMTU433_1721	COG4993	Dehydrogenase
IOMTU433_1723	COG2391	methyltransferase activity
IOMTU433_1726	COG1414	Transcriptional regulator
IOMTU433_1727	COG0583	DNA-binding transcription factor activity
IOMTU433_1728	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_1733	COG2814	Major facilitator Superfamily
IOMTU433_1735	COG0154	amidase activity
IOMTU433_1739	COG4638	Rieske (2fe-2S)
IOMTU433_1741	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1743	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_1745	COG3733	amine oxidase
IOMTU433_1747	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_1749	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOMTU433_1750	COG0183	Belongs to the thiolase family
IOMTU433_1751	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOMTU433_1752	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOMTU433_1754	COG4829	muconolactone delta-isomerase
IOMTU433_1755	COG4948	Mandelate Racemase Muconate Lactonizing
IOMTU433_1756	COG0583	DNA-binding transcription factor activity
IOMTU433_1758	COG2186	Transcriptional regulator
IOMTU433_1762	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_1765	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_1765	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_1767	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOMTU433_1774	COG1309	transcriptional regulator
IOMTU433_1775	COG0583	DNA-binding transcription factor activity
IOMTU433_1776	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1777	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1778	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1780	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_1782	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_1802	COG0583	DNA-binding transcription factor activity
IOMTU433_1808	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOMTU433_1812	COG1566	PFAM secretion protein HlyD family protein
IOMTU433_1815	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_1816	COG0129	dihydroxy-acid dehydratase activity
IOMTU433_1818	COG0583	DNA-binding transcription factor activity
IOMTU433_1819	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOMTU433_1821	COG2084	Dehydrogenase
IOMTU433_1822	COG2207	Transcriptional regulator
IOMTU433_1825	COG1064	alcohol dehydrogenase
IOMTU433_1829	COG1120	ATPase activity
IOMTU433_1833	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOMTU433_1844	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOMTU433_1854	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IOMTU433_1857	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1859	COG2207	Transcriptional regulator
IOMTU433_1861	COG2205	protein histidine kinase activity
IOMTU433_1862	COG0745	RESPONSE REGULATOR receiver
IOMTU433_1863	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_1864	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOMTU433_1874	COG3539	Fimbrial protein
IOMTU433_1879	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOMTU433_1881	COG0753	catalase activity
IOMTU433_1884	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOMTU433_1897	COG1535	isochorismatase
IOMTU433_1897	COG3433	isochorismatase activity
IOMTU433_1898	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1899	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOMTU433_1900	COG4149	molybdate abc transporter
IOMTU433_1901	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOMTU433_1903	COG4638	Rieske (2fe-2S)
IOMTU433_1904	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOMTU433_1905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_1905	COG0543	2 iron, 2 sulfur cluster binding
IOMTU433_1908	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_1910	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1911	COG0412	Dienelactone hydrolase
IOMTU433_1913	COG2207	Transcriptional regulator
IOMTU433_1914	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_1915	COG2610	gluconate transmembrane transporter activity
IOMTU433_1917	COG1309	transcriptional regulator
IOMTU433_1921	COG0583	DNA-binding transcription factor activity
IOMTU433_1924	COG2031	fatty acid transporter
IOMTU433_1925	COG0183	Belongs to the thiolase family
IOMTU433_1926	COG0583	DNA-binding transcription factor activity
IOMTU433_1927	COG0583	DNA-binding transcription factor activity
IOMTU433_1930	COG1027	Aspartate ammonia-lyase
IOMTU433_1932	COG0477	Major facilitator Superfamily
IOMTU433_1936	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_1937	COG4521	taurine ABC transporter
IOMTU433_1942	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOMTU433_1943	COG1733	regulation of RNA biosynthetic process
IOMTU433_1944	COG2207	Transcriptional regulator
IOMTU433_1944	COG3708	Transcriptional regulator
IOMTU433_1947	COG0730	response to heat
IOMTU433_1949	COG3453	Protein conserved in bacteria
IOMTU433_1949	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOMTU433_1951	COG3781	membrane
IOMTU433_1952	COG1063	alcohol dehydrogenase
IOMTU433_1954	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOMTU433_1955	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOMTU433_1956	COG0022	dehydrogenase e1 component
IOMTU433_1957	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOMTU433_1958	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOMTU433_1961	COG3706	GGDEF domain
IOMTU433_1964	COG0133	tryptophan synthase activity
IOMTU433_1966	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOMTU433_1973	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOMTU433_1979	COG2226	methyltransferase
IOMTU433_1990	COG0842	Transport permease protein
IOMTU433_1991	COG0842	Transport permease protein
IOMTU433_1992	COG1131	(ABC) transporter
IOMTU433_1995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOMTU433_1996	COG4773	Receptor
IOMTU433_1999	COG0730	response to heat
IOMTU433_2000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOMTU433_2003	COG0406	alpha-ribazole phosphatase activity
IOMTU433_2014	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOMTU433_2016	COG4264	IucA IucC family
IOMTU433_2017	COG4264	IucA IucC family
IOMTU433_2021	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOMTU433_2024	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2025	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2026	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOMTU433_2027	COG2207	Transcriptional regulator
IOMTU433_2028	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOMTU433_2029	COG0776	regulation of translation
IOMTU433_2034	COG0822	iron-sulfur transferase activity
IOMTU433_2035	COG0316	Belongs to the HesB IscA family
IOMTU433_2041	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOMTU433_2045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOMTU433_2046	COG0702	epimerase
IOMTU433_2053	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOMTU433_2055	COG0339	signal peptide processing
IOMTU433_2063	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOMTU433_2064	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOMTU433_2070	COG0776	regulation of translation
IOMTU433_2074	COG0590	tRNA wobble adenosine to inosine editing
IOMTU433_2083	COG0084	hydrolase, TatD family'
IOMTU433_2087	COG1663	tetraacyldisaccharide 4'-kinase activity
IOMTU433_2088	COG1132	(ABC) transporter
IOMTU433_2090	COG0811	peptide transport
IOMTU433_2091	COG1475	DNA binding
IOMTU433_2092	COG1192	Involved in chromosome partitioning
IOMTU433_2094	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IOMTU433_2097	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOMTU433_2098	COG0191	fructose-bisphosphate aldolase activity
IOMTU433_2102	COG0424	maF-like protein
IOMTU433_2103	COG2850	peptidyl-arginine hydroxylation
IOMTU433_2105	COG0640	Transcriptional regulator
IOMTU433_2107	COG3619	membrane
IOMTU433_2108	COG3122	Protein conserved in bacteria
IOMTU433_2109	COG1132	(ABC) transporter
IOMTU433_2113	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOMTU433_2114	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOMTU433_2116	COG0506	proline dehydrogenase activity
IOMTU433_2116	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOMTU433_2116	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOMTU433_2117	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOMTU433_2120	COG3698	Phosphodiester glycosidase
IOMTU433_2122	COG2353	YceI-like domain
IOMTU433_2124	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOMTU433_2135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IOMTU433_2135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOMTU433_2140	COG3539	Fimbrial protein
IOMTU433_2141	COG3121	Chaperone
IOMTU433_2146	COG0697	spore germination
IOMTU433_2148	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOMTU433_2150	COG0583	DNA-binding transcription factor activity
IOMTU433_2155	COG1309	transcriptional regulator
IOMTU433_2158	COG1522	sequence-specific DNA binding
IOMTU433_2160	COG1126	abc transporter atp-binding protein
IOMTU433_2161	COG0765	amino acid transport
IOMTU433_2162	COG0765	amino acid transport
IOMTU433_2168	COG1464	Belongs to the NlpA lipoprotein family
IOMTU433_2170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOMTU433_2171	COG2011	ABC-type metal ion transport system permease component
IOMTU433_2172	COG0012	GTP binding
IOMTU433_2177	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOMTU433_2185	COG0386	Belongs to the glutathione peroxidase family
IOMTU433_2187	COG0436	Aminotransferase
IOMTU433_2188	COG1301	dicarboxylic acid transport
IOMTU433_2195	COG3634	alkyl hydroperoxide reductase activity
IOMTU433_2198	COG0583	DNA-binding transcription factor activity
IOMTU433_2199	COG0798	PFAM Bile acid sodium symporter
IOMTU433_2200	COG0640	Transcriptional regulator
IOMTU433_2203	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IOMTU433_2205	COG0583	DNA-binding transcription factor activity
IOMTU433_2207	COG1953	Uracil, thiamine, allantoin
IOMTU433_2209	COG2175	clavaminate synthase activity
IOMTU433_2210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_2211	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IOMTU433_2212	COG4521	taurine ABC transporter
IOMTU433_2214	COG0477	Major facilitator Superfamily
IOMTU433_2218	COG1271	oxidase subunit
IOMTU433_2219	COG1294	oxidase, subunit
IOMTU433_2221	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_2225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOMTU433_2229	COG3052	prosthetic group binding
IOMTU433_2230	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IOMTU433_2232	COG0583	DNA-binding transcription factor activity
IOMTU433_2234	COG2814	Major facilitator Superfamily
IOMTU433_2238	COG1346	cytolysis
IOMTU433_2240	COG0583	DNA-binding transcription factor activity
IOMTU433_2241	COG0625	glutathione transferase activity
IOMTU433_2242	COG0625	glutathione transferase activity
IOMTU433_2243	COG0583	DNA-binding transcription factor activity
IOMTU433_2246	COG1045	serine acetyltransferase
IOMTU433_2247	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOMTU433_2248	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOMTU433_2249	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_2251	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOMTU433_2252	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOMTU433_2254	COG0765	amino acid transport
IOMTU433_2255	COG0765	amino acid transport
IOMTU433_2258	COG0784	Response regulator, receiver
IOMTU433_2258	COG2205	protein histidine kinase activity
IOMTU433_2262	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOMTU433_2266	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_2276	COG0583	DNA-binding transcription factor activity
IOMTU433_2280	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_2281	COG1309	transcriptional regulator
IOMTU433_2282	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2283	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOMTU433_2284	COG1024	Enoyl-CoA hydratase
IOMTU433_2287	COG0583	DNA-binding transcription factor activity
IOMTU433_2290	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2292	COG2814	Major facilitator Superfamily
IOMTU433_2294	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOMTU433_2295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOMTU433_2296	COG2814	Major facilitator Superfamily
IOMTU433_2297	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2298	COG1024	Enoyl-CoA hydratase
IOMTU433_2299	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_2300	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_2301	COG0183	Belongs to the thiolase family
IOMTU433_2303	COG2814	Major facilitator Superfamily
IOMTU433_2305	COG1024	Enoyl-CoA hydratase
IOMTU433_2308	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2309	COG2814	Major facilitator Superfamily
IOMTU433_2310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOMTU433_2311	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOMTU433_2314	COG3842	ATPase activity
IOMTU433_2315	COG1840	ABC-type Fe3 transport system, periplasmic component
IOMTU433_2317	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_2318	COG1414	Transcriptional regulator
IOMTU433_2320	COG0583	DNA-binding transcription factor activity
IOMTU433_2321	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOMTU433_2322	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2324	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOMTU433_2326	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2327	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOMTU433_2328	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_2329	COG2267	carboxylic ester hydrolase activity
IOMTU433_2333	COG3038	cytochrome b561
IOMTU433_2334	COG0753	catalase activity
IOMTU433_2335	COG2271	Major facilitator Superfamily
IOMTU433_2336	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOMTU433_2337	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOMTU433_2340	COG2207	Transcriptional regulator
IOMTU433_2350	COG2050	protein possibly involved in aromatic compounds catabolism
IOMTU433_2352	COG3327	negative regulation of DNA-templated transcription, initiation
IOMTU433_2353	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IOMTU433_2354	COG0183	Belongs to the thiolase family
IOMTU433_2355	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_2358	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_2359	COG1024	Enoyl-CoA hydratase
IOMTU433_2360	COG1024	Enoyl-CoA hydratase
IOMTU433_2361	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_2362	COG2151	metal-sulfur cluster biosynthetic enzyme
IOMTU433_2363	COG3396	Phenylacetate-CoA oxygenase
IOMTU433_2364	COG3460	Phenylacetate-CoA oxygenase
IOMTU433_2365	COG3396	Phenylacetate-CoA oxygenase
IOMTU433_2366	COG2030	dehydratase
IOMTU433_2366	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2367	COG1760	l-serine dehydratase
IOMTU433_2368	COG0531	amino acid
IOMTU433_2369	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2374	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOMTU433_2378	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_2380	COG0789	Transcriptional regulator
IOMTU433_2381	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOMTU433_2384	COG2807	transmembrane transport
IOMTU433_2385	COG0590	tRNA wobble adenosine to inosine editing
IOMTU433_2387	COG0583	DNA-binding transcription factor activity
IOMTU433_2395	COG2885	chlorophyll binding
IOMTU433_2395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOMTU433_2408	COG1116	anion transmembrane transporter activity
IOMTU433_2411	COG0864	Transcriptional regulator
IOMTU433_2413	COG1733	regulation of RNA biosynthetic process
IOMTU433_2414	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_2415	COG0439	Biotin carboxylase
IOMTU433_2418	COG1063	alcohol dehydrogenase
IOMTU433_2420	COG1309	transcriptional regulator
IOMTU433_2422	COG3210	domain, Protein
IOMTU433_2423	COG2831	hemolysin activation secretion protein
IOMTU433_2424	COG0038	chloride channel
IOMTU433_2425	COG4770	biotin carboxylase activity
IOMTU433_2429	COG1914	H( )-stimulated, divalent metal cation uptake system
IOMTU433_2430	COG0583	DNA-binding transcription factor activity
IOMTU433_2437	COG3209	COG3209 Rhs family protein
IOMTU433_2438	COG3501	Rhs element vgr protein
IOMTU433_2444	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_2448	COG2814	Major facilitator Superfamily
IOMTU433_2450	COG1560	Kdo2-lipid A biosynthetic process
IOMTU433_2452	COG5006	permease, DMT superfamily
IOMTU433_2453	COG1522	sequence-specific DNA binding
IOMTU433_2457	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IOMTU433_2465	COG1538	Outer membrane efflux protein
IOMTU433_2466	COG1137	ATPase activity
IOMTU433_2467	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOMTU433_2469	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOMTU433_2470	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOMTU433_2470	COG0517	IMP dehydrogenase activity
IOMTU433_2479	COG1733	regulation of RNA biosynthetic process
IOMTU433_2480	COG2814	Major facilitator Superfamily
IOMTU433_2487	COG1278	Cold shock
IOMTU433_2488	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_2494	COG1570	exodeoxyribonuclease VII activity
IOMTU433_2510	COG2871	sodium ion transport
IOMTU433_2512	COG0583	DNA-binding transcription factor activity
IOMTU433_2513	COG4638	Rieske (2fe-2S)
IOMTU433_2514	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOMTU433_2515	COG0543	2 iron, 2 sulfur cluster binding
IOMTU433_2515	COG0633	Ferredoxin
IOMTU433_2516	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_2517	COG3135	benzoate transporter
IOMTU433_2518	COG2814	Major facilitator Superfamily
IOMTU433_2521	COG1643	Atp-dependent helicase
IOMTU433_2522	COG0450	alkyl hydroperoxide reductase
IOMTU433_2524	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOMTU433_2526	COG3634	alkyl hydroperoxide reductase activity
IOMTU433_2530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOMTU433_2531	COG0625	glutathione transferase activity
IOMTU433_2533	COG2885	chlorophyll binding
IOMTU433_2543	COG1765	OsmC-like protein
IOMTU433_2546	COG0667	Aldo Keto reductase
IOMTU433_2549	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOMTU433_2552	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOMTU433_2554	COG0582	viral genome integration into host DNA
IOMTU433_2580	COG3566	protein conserved in bacteria
IOMTU433_2584	COG3567	Phage-associated protein, HI1409 family
IOMTU433_2585	COG5410	chromosome segregation
IOMTU433_2604	COG4197	protein conserved in bacteria, prophage-related
IOMTU433_2605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOMTU433_2617	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOMTU433_2619	COG3038	cytochrome b561
IOMTU433_2620	COG2801	Transposase and inactivated derivatives
IOMTU433_2622	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOMTU433_2623	COG2252	PERMEase
IOMTU433_2625	COG2072	flavoprotein involved in K transport
IOMTU433_2628	COG1741	Belongs to the pirin family
IOMTU433_2629	COG1309	transcriptional regulator
IOMTU433_2631	COG0300	oxidoreductase activity
IOMTU433_2632	COG2072	flavoprotein involved in K transport
IOMTU433_2633	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IOMTU433_2642	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOMTU433_2645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_2648	COG2814	Major facilitator Superfamily
IOMTU433_2649	COG1024	Enoyl-CoA hydratase
IOMTU433_2650	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2652	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_2657	COG2186	Transcriptional regulator
IOMTU433_2658	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2660	COG4948	Mandelate Racemase Muconate Lactonizing
IOMTU433_2661	COG2271	Major facilitator Superfamily
IOMTU433_2662	COG2721	sulfolactate sulfo-lyase activity
IOMTU433_2663	COG0697	spore germination
IOMTU433_2669	COG1113	amino acid transport
IOMTU433_2673	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2677	COG0531	amino acid
IOMTU433_2679	COG1113	amino acid transport
IOMTU433_2683	COG3209	COG3209 Rhs family protein
IOMTU433_2684	COG3501	Rhs element vgr protein
IOMTU433_2689	COG4269	membrane
IOMTU433_2692	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_2692	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_2695	COG3706	GGDEF domain
IOMTU433_2695	COG2203	Gaf domain
IOMTU433_2695	COG5001	Diguanylate cyclase
IOMTU433_2695	COG4251	negative regulation of phosphorylation
IOMTU433_2697	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOMTU433_2701	COG4172	Belongs to the ABC transporter superfamily
IOMTU433_2702	COG4239	(ABC) transporter, permease
IOMTU433_2703	COG4174	ABC transporter (Permease)
IOMTU433_2705	COG0741	lytic transglycosylase activity
IOMTU433_2705	COG1388	LysM domain
IOMTU433_2705	COG0741	lytic transglycosylase activity
IOMTU433_2705	COG1388	LysM domain
IOMTU433_2706	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOMTU433_2714	COG0583	DNA-binding transcription factor activity
IOMTU433_2715	COG1279	arginine transmembrane transporter activity
IOMTU433_2720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_2721	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_2722	COG0006	proline dipeptidase activity
IOMTU433_2728	COG2194	sulfuric ester hydrolase activity
IOMTU433_2738	COG0739	heme binding
IOMTU433_2741	COG1598	PFAM Uncharacterised protein family UPF0150
IOMTU433_2772	COG0270	DNA (cytosine-5-)-methyltransferase activity
IOMTU433_2791	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOMTU433_2796	COG3384	dioxygenase
IOMTU433_2798	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOMTU433_2799	COG2878	Part of a membrane complex involved in electron transport
IOMTU433_2800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOMTU433_2804	COG0768	penicillin binding
IOMTU433_2805	COG0742	ribosomal rna small subunit methyltransferase
IOMTU433_2808	COG0830	nickel cation binding
IOMTU433_2810	COG0804	urea catabolic process
IOMTU433_2819	COG1253	flavin adenine dinucleotide binding
IOMTU433_2820	COG2851	Citrate transporter
IOMTU433_2830	COG1773	rubredoxin
IOMTU433_2831	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_2833	COG0583	DNA-binding transcription factor activity
IOMTU433_2838	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IOMTU433_2839	COG4181	ATPase activity
IOMTU433_2848	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOMTU433_2853	COG0306	phosphate transporter
IOMTU433_2855	COG3958	Transketolase
IOMTU433_2856	COG3959	Transketolase, thiamine diphosphate binding domain
IOMTU433_2857	COG2271	Major facilitator Superfamily
IOMTU433_2858	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_2859	COG0583	DNA-binding transcription factor activity
IOMTU433_2862	COG2223	nitrite transmembrane transporter activity
IOMTU433_2863	COG2207	Transcriptional regulator
IOMTU433_2864	COG2066	Belongs to the glutaminase family
IOMTU433_2865	COG0242	peptide deformylase activity
IOMTU433_2867	COG0477	Major facilitator Superfamily
IOMTU433_2869	COG0028	Belongs to the TPP enzyme family
IOMTU433_2872	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_2873	COG2267	carboxylic ester hydrolase activity
IOMTU433_2875	COG2271	Major facilitator Superfamily
IOMTU433_2876	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_2878	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_2882	COG1414	Transcriptional regulator
IOMTU433_2885	COG1024	Enoyl-CoA hydratase
IOMTU433_2887	COG1215	transferase activity, transferring glycosyl groups
IOMTU433_2888	COG0726	polysaccharide deacetylase
IOMTU433_2888	COG1649	PFAM Uncharacterised BCR, COG1649
IOMTU433_2890	COG4681	YaeQ
IOMTU433_2892	COG0523	cobalamin synthesis protein
IOMTU433_2894	COG1607	acyl-coa hydrolase
IOMTU433_2896	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOMTU433_2897	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOMTU433_2898	COG1309	transcriptional regulator
IOMTU433_2903	COG2040	homocysteine
IOMTU433_2904	COG0531	amino acid
IOMTU433_2916	COG1595	DNA-templated transcription, initiation
IOMTU433_2918	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_2919	COG0477	Major facilitator Superfamily
IOMTU433_2929	COG0405	Gamma-glutamyltransferase
IOMTU433_2930	COG2814	Major facilitator Superfamily
IOMTU433_2932	COG2050	protein possibly involved in aromatic compounds catabolism
IOMTU433_2935	COG1090	epimerase
IOMTU433_2939	COG0420	3'-5' exonuclease activity
IOMTU433_2944	COG0735	belongs to the Fur family
IOMTU433_2945	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOMTU433_2949	COG0121	glutamine amidotransferase
IOMTU433_2952	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOMTU433_2954	COG0210	DNA helicase
IOMTU433_2955	COG2885	chlorophyll binding
IOMTU433_2956	COG0204	Acyl-transferase
IOMTU433_2959	COG2894	cell division
IOMTU433_2962	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_2963	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOMTU433_2963	COG1674	ftsk spoiiie
IOMTU433_2964	COG0492	ferredoxin-NADP+ reductase activity
IOMTU433_2965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IOMTU433_2967	COG0456	acetyltransferase
IOMTU433_2979	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOMTU433_2979	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IOMTU433_2983	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_2987	COG0473	3-isopropylmalate dehydrogenase activity
IOMTU433_2988	COG0583	DNA-binding transcription factor activity
IOMTU433_2991	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOMTU433_2996	COG0564	pseudouridine synthase activity
IOMTU433_2998	COG0358	DNA primase activity
IOMTU433_3001	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IOMTU433_3007	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOMTU433_3013	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOMTU433_3015	COG0351	phosphomethylpyrimidine kinase
IOMTU433_3015	COG0352	thiamine-phosphate diphosphorylase activity
IOMTU433_3015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOMTU433_3016	COG1652	LysM domain
IOMTU433_3021	COG1399	metal-binding, possibly nucleic acid-binding protein
IOMTU433_3022	COG3101	peptidyl-lysine hydroxylation
IOMTU433_3023	COG0009	L-threonylcarbamoyladenylate synthase
IOMTU433_3024	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IOMTU433_3025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IOMTU433_3028	COG4106	trans-aconitate 2-methyltransferase activity
IOMTU433_3031	COG0596	Alpha beta hydrolase
IOMTU433_3031	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOMTU433_3031	COG2226	methyltransferase
IOMTU433_3032	COG1877	trehalose-phosphatase activity
IOMTU433_3033	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IOMTU433_3034	COG2223	nitrite transmembrane transporter activity
IOMTU433_3038	COG1196	nuclear chromosome segregation
IOMTU433_3040	COG0730	response to heat
IOMTU433_3043	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOMTU433_3045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOMTU433_3056	COG0489	protein tyrosine kinase activity
IOMTU433_3058	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOMTU433_3058	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOMTU433_3064	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IOMTU433_3065	COG2081	HI0933 family
IOMTU433_3067	COG0668	transmembrane transport
IOMTU433_3071	COG0583	DNA-binding transcription factor activity
IOMTU433_3076	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOMTU433_3077	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOMTU433_3083	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IOMTU433_3090	COG2205	protein histidine kinase activity
IOMTU433_3091	COG0745	RESPONSE REGULATOR receiver
IOMTU433_3094	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOMTU433_3095	COG0697	spore germination
IOMTU433_3102	COG0477	Major facilitator Superfamily
IOMTU433_3104	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_3113	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_3114	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOMTU433_3118	COG1473	amidohydrolase
IOMTU433_3120	COG0583	DNA-binding transcription factor activity
IOMTU433_3123	COG0583	DNA-binding transcription factor activity
IOMTU433_3124	COG1053	succinate dehydrogenase
IOMTU433_3126	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOMTU433_3127	COG2814	Major facilitator Superfamily
IOMTU433_3128	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_3129	COG0583	DNA-binding transcription factor activity
IOMTU433_3130	COG1063	alcohol dehydrogenase
IOMTU433_3136	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOMTU433_3137	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IOMTU433_3138	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOMTU433_3142	COG2132	Multicopper oxidase
IOMTU433_3144	COG0561	phosphatase activity
IOMTU433_3145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOMTU433_3147	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IOMTU433_3150	COG1214	PFAM Peptidase M22, glycoprotease
IOMTU433_3160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOMTU433_3162	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOMTU433_3163	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOMTU433_3164	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOMTU433_3176	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOMTU433_3178	COG1846	Transcriptional regulator
IOMTU433_3179	COG1764	response to oxidative stress
IOMTU433_3187	COG0037	tRNA processing
IOMTU433_3189	COG0248	Ppx GppA phosphatase
IOMTU433_3194	COG0072	phenylalanine-tRNA ligase activity
IOMTU433_3199	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOMTU433_3202	COG1238	metal cluster binding
IOMTU433_3203	COG0625	glutathione transferase activity
IOMTU433_3206	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_3207	COG3028	Belongs to the UPF0307 family
IOMTU433_3208	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOMTU433_3212	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOMTU433_3213	COG0617	tRNA 3'-terminal CCA addition
IOMTU433_3214	COG1555	photosystem II stabilization
IOMTU433_3215	COG3956	TIGRFAM MazG family protein
IOMTU433_3217	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOMTU433_3221	COG0784	Response regulator, receiver
IOMTU433_3221	COG2205	protein histidine kinase activity
IOMTU433_3221	COG5002	protein histidine kinase activity
IOMTU433_3222	COG1024	Enoyl-CoA hydratase
IOMTU433_3223	COG2084	Dehydrogenase
IOMTU433_3224	COG3622	Belongs to the hyi family
IOMTU433_3227	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IOMTU433_3228	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOMTU433_3229	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IOMTU433_3230	COG0697	spore germination
IOMTU433_3232	COG2814	Major facilitator Superfamily
IOMTU433_3236	COG2132	Multicopper oxidase
IOMTU433_3239	COG2205	protein histidine kinase activity
IOMTU433_3257	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOMTU433_3259	COG0583	DNA-binding transcription factor activity
IOMTU433_3260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOMTU433_3262	COG0084	hydrolase, TatD family'
IOMTU433_3265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOMTU433_3273	COG0440	acetolactate synthase activity
IOMTU433_3274	COG0028	Belongs to the TPP enzyme family
IOMTU433_3279	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_3280	COG1136	(ABC) transporter
IOMTU433_3280	COG0577	efflux transmembrane transporter activity
IOMTU433_3281	COG1538	Outer membrane efflux protein
IOMTU433_3284	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOMTU433_3285	COG1162	GTPase activity
IOMTU433_3287	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOMTU433_3295	COG1426	Protein conserved in bacteria
IOMTU433_3302	COG0793	Belongs to the peptidase S41A family
IOMTU433_3305	COG2267	carboxylic ester hydrolase activity
IOMTU433_3307	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_3308	COG3265	gluconokinase activity
IOMTU433_3310	COG0800	Aldolase
IOMTU433_3312	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOMTU433_3313	COG0280	phosphate acetyltransferase
IOMTU433_3313	COG0857	belongs to the CobB CobQ family
IOMTU433_3314	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOMTU433_3314	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOMTU433_3318	COG0740	serine-type endopeptidase activity
IOMTU433_3320	COG4774	siderophore transport
IOMTU433_3322	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOMTU433_3324	COG2813	Specifically methylates the guanine in position
IOMTU433_3324	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOMTU433_3344	COG0788	formyltetrahydrofolate deformylase activity
IOMTU433_3347	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOMTU433_3348	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOMTU433_3349	COG4651	solute:proton antiporter activity
IOMTU433_3349	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOMTU433_3352	COG0724	RNA recognition motif
IOMTU433_3353	COG0210	DNA helicase
IOMTU433_3358	COG1733	regulation of RNA biosynthetic process
IOMTU433_3362	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_3363	COG1560	Kdo2-lipid A biosynthetic process
IOMTU433_3365	COG1301	dicarboxylic acid transport
IOMTU433_3376	COG0473	3-isopropylmalate dehydrogenase activity
IOMTU433_3389	COG0583	DNA-binding transcription factor activity
IOMTU433_3391	COG0625	glutathione transferase activity
IOMTU433_3392	COG2378	regulation of single-species biofilm formation
IOMTU433_3393	COG0546	phosphoglycolate phosphatase activity
IOMTU433_3396	COG1530	ribonuclease E activity
IOMTU433_3400	COG0583	DNA-binding transcription factor activity
IOMTU433_3401	COG4221	oxidoreductase activity
IOMTU433_3402	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOMTU433_3404	COG0534	Mate efflux family protein
IOMTU433_3407	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOMTU433_3414	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IOMTU433_3415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOMTU433_3418	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOMTU433_3420	COG0644	oxidoreductase
IOMTU433_3420	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IOMTU433_3422	COG0425	Belongs to the sulfur carrier protein TusA family
IOMTU433_3423	COG4535	Mg2 and Co2 transporter CorC
IOMTU433_3425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOMTU433_3429	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOMTU433_3430	COG0475	glutathione-regulated potassium exporter activity
IOMTU433_3430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOMTU433_3433	COG0484	heat shock protein binding
IOMTU433_3434	COG0789	Transcriptional regulator
IOMTU433_3435	COG0598	Magnesium transport protein CorA
IOMTU433_3439	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOMTU433_3440	COG1074	ATP-dependent DNA helicase activity
IOMTU433_3441	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOMTU433_3445	COG2226	methyltransferase
IOMTU433_3449	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOMTU433_3452	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOMTU433_3452	COG2111	Na H antiporter
IOMTU433_3453	COG1006	Multisubunit Na H antiporter MnhC subunit
IOMTU433_3454	COG0651	ATP synthesis coupled electron transport
IOMTU433_3456	COG2212	antiporter activity
IOMTU433_3460	COG0195	Participates in both transcription termination and antitermination
IOMTU433_3470	COG0237	dephospho-CoA kinase activity
IOMTU433_3472	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOMTU433_3475	COG0497	DNA recombination
IOMTU433_3477	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOMTU433_3483	COG2169	Transcriptional regulator
IOMTU433_3483	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOMTU433_3484	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOMTU433_3496	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOMTU433_3499	COG0326	Molecular chaperone. Has ATPase activity
IOMTU433_3502	COG2056	Na+-H+ antiporter family
IOMTU433_3503	COG0596	Alpha beta hydrolase
IOMTU433_3522	COG0546	phosphoglycolate phosphatase activity
IOMTU433_3523	COG1716	ATPase activity
IOMTU433_3532	COG0181	hydroxymethylbilane synthase activity
IOMTU433_3534	COG3275	phosphorelay sensor kinase activity
IOMTU433_3538	COG1538	Outer membrane efflux protein
IOMTU433_3539	COG0697	spore germination
IOMTU433_3544	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOMTU433_3545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOMTU433_3546	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOMTU433_3547	COG0772	Belongs to the SEDS family
IOMTU433_3552	COG4974	Belongs to the 'phage' integrase family
IOMTU433_3553	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOMTU433_3555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOMTU433_3557	COG2197	response regulator
IOMTU433_3560	COG0793	Belongs to the peptidase S41A family
IOMTU433_3561	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IOMTU433_3562	COG0795	lipopolysaccharide-transporting ATPase activity
IOMTU433_3570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOMTU433_3570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOMTU433_3572	COG0004	ammonium transporteR
IOMTU433_3573	COG0347	Belongs to the P(II) protein family
IOMTU433_3575	COG0606	chelatase, subunit chli
IOMTU433_3581	COG1061	Type III restriction enzyme res subunit
IOMTU433_3585	COG0659	secondary active sulfate transmembrane transporter activity
IOMTU433_3586	COG0589	response to stress
IOMTU433_3594	COG0606	chelatase, subunit chli
IOMTU433_3595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_3597	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_3600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOMTU433_3603	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_3605	COG0477	Major facilitator Superfamily
IOMTU433_3606	COG2860	membrane
IOMTU433_3608	COG1253	flavin adenine dinucleotide binding
IOMTU433_3613	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOMTU433_3620	COG0655	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_3622	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOMTU433_3629	COG1309	transcriptional regulator
IOMTU433_3636	COG0758	DNA mediated transformation
IOMTU433_3638	COG0697	spore germination
IOMTU433_3639	COG1309	transcriptional regulator
IOMTU433_3642	COG0386	Belongs to the glutathione peroxidase family
IOMTU433_3655	COG1121	(ABC) transporter
IOMTU433_3656	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOMTU433_3657	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_3658	COG2837	iron assimilation
IOMTU433_3659	COG0281	malic enzyme
IOMTU433_3668	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOMTU433_3668	COG0519	Catalyzes the synthesis of GMP from XMP
IOMTU433_3669	COG4399	Belongs to the UPF0754 family
IOMTU433_3670	COG2259	Doxx family
IOMTU433_3671	COG0586	Pfam SNARE associated Golgi protein
IOMTU433_3674	COG1192	Involved in chromosome partitioning
IOMTU433_3676	COG0271	Belongs to the BolA IbaG family
IOMTU433_3684	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOMTU433_3684	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IOMTU433_3684	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IOMTU433_3684	COG3321	synthase
IOMTU433_3685	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_3687	COG2197	response regulator
IOMTU433_3689	COG3916	Acyl-homoserine-lactone synthase
IOMTU433_3690	COG0477	Major facilitator Superfamily
IOMTU433_3691	COG1024	Enoyl-CoA hydratase
IOMTU433_3692	COG1024	Enoyl-CoA hydratase
IOMTU433_3693	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_3694	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOMTU433_3698	COG1113	amino acid transport
IOMTU433_3699	COG1113	amino acid transport
IOMTU433_3700	COG0251	oxidation-reduction process
IOMTU433_3703	COG1522	sequence-specific DNA binding
IOMTU433_3708	COG0564	pseudouridine synthase activity
IOMTU433_3716	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOMTU433_3719	COG1802	Transcriptional regulator
IOMTU433_3720	COG1448	Aminotransferase
IOMTU433_3721	COG0277	FAD linked oxidase domain protein
IOMTU433_3723	COG2186	Transcriptional regulator
IOMTU433_3725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOMTU433_3727	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOMTU433_3730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOMTU433_3731	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOMTU433_3732	COG1216	Glycosyl transferase, family 2
IOMTU433_3736	COG0438	transferase activity, transferring glycosyl groups
IOMTU433_3742	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOMTU433_3748	COG0728	peptidoglycan biosynthetic process
IOMTU433_3749	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOMTU433_3761	COG0546	phosphoglycolate phosphatase activity
IOMTU433_3762	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_3766	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_3767	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_3768	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOMTU433_3769	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_3770	COG1116	anion transmembrane transporter activity
IOMTU433_3771	COG1309	transcriptional regulator
IOMTU433_3772	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOMTU433_3775	COG0196	riboflavin kinase activity
IOMTU433_3776	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOMTU433_3778	COG1047	Peptidyl-prolyl cis-trans
IOMTU433_3786	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOMTU433_3791	COG0583	DNA-binding transcription factor activity
IOMTU433_3797	COG2951	lytic endotransglycosylase activity
IOMTU433_3798	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOMTU433_3802	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOMTU433_3804	COG0671	phosphoesterase, PA-phosphatase related
IOMTU433_3805	COG0861	Integral membrane protein TerC family
IOMTU433_3807	COG0754	glutathionylspermidine amidase activity
IOMTU433_3809	COG0402	S-adenosylhomocysteine deaminase activity
IOMTU433_3813	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOMTU433_3814	COG1230	cation diffusion facilitator family transporter
IOMTU433_p003	COG3173	Aminoglycoside phosphotransferase
IOMTU433_p015	COG1132	(ABC) transporter
IOMTU433_p025	COG3316	Transposase and inactivated derivatives
IOMTU433_p037	COG1192	Involved in chromosome partitioning
IOMTU433_p041	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOMTU433_p050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOMTU433_p064	COG3316	Transposase and inactivated derivatives
IOMTU433_p069	COG3316	Transposase and inactivated derivatives
IOMTU433_p080	COG1373	ATPase (AAA superfamily
IOMTU433_p087	COG1309	transcriptional regulator
IOMTU433_p092	COG0633	Ferredoxin
IOMTU433_p093	COG2207	Transcriptional regulator
IOMTU433_p097	COG3316	Transposase and inactivated derivatives
IOMTU433_p126	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOMTU433_p136	COG1192	Involved in chromosome partitioning
IOMTU433_p138	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOMTU433_p146	COG0739	heme binding
IOMTU433_p193	COG0501	Belongs to the peptidase M48B family
IOMTU433_p200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IOMTU433_p204	COG3316	Transposase and inactivated derivatives