locus-tag	class	description
NIK71_00035	COG1192	Involved in chromosome partitioning
NIK71_00040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIK71_00050	COG1061	Type III restriction enzyme res subunit
NIK71_00070	COG1061	Type III restriction enzyme res subunit
NIK71_00080	COG1192	Involved in chromosome partitioning
NIK71_00085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIK71_00095	COG1061	Type III restriction enzyme res subunit
NIK71_00130	COG0384	phenazine biosynthesis protein PhzF
NIK71_00155	COG4993	Dehydrogenase
NIK71_00225	COG2205	protein histidine kinase activity
NIK71_00235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIK71_00255	COG0745	RESPONSE REGULATOR receiver
NIK71_00295	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NIK71_00325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIK71_00330	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIK71_00350	COG0583	DNA-binding transcription factor activity
NIK71_00370	COG0668	transmembrane transport
NIK71_00380	COG2081	HI0933 family
NIK71_00385	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NIK71_00415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIK71_00415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIK71_00425	COG0489	protein tyrosine kinase activity
NIK71_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIK71_00485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NIK71_00500	COG0730	response to heat
NIK71_00510	COG1196	nuclear chromosome segregation
NIK71_00530	COG2223	nitrite transmembrane transporter activity
NIK71_00535	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NIK71_00540	COG1877	trehalose-phosphatase activity
NIK71_00545	COG0596	Alpha beta hydrolase
NIK71_00545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIK71_00545	COG2226	methyltransferase
NIK71_00560	COG4106	trans-aconitate 2-methyltransferase activity
NIK71_00575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NIK71_00580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NIK71_00585	COG0009	L-threonylcarbamoyladenylate synthase
NIK71_00590	COG3101	peptidyl-lysine hydroxylation
NIK71_00595	COG1399	metal-binding, possibly nucleic acid-binding protein
NIK71_00620	COG1652	LysM domain
NIK71_00625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NIK71_00625	COG0352	thiamine-phosphate diphosphorylase activity
NIK71_00625	COG0351	phosphomethylpyrimidine kinase
NIK71_00635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIK71_00665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIK71_00695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NIK71_00710	COG0358	DNA primase activity
NIK71_00720	COG0564	pseudouridine synthase activity
NIK71_00745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIK71_00765	COG0583	DNA-binding transcription factor activity
NIK71_00770	COG0473	3-isopropylmalate dehydrogenase activity
NIK71_00780	COG0657	acetylesterase activity
NIK71_00790	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_00810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NIK71_00810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIK71_00825	COG1981	membrane
NIK71_00870	COG0456	acetyltransferase
NIK71_00880	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NIK71_00885	COG0492	ferredoxin-NADP+ reductase activity
NIK71_00890	COG1674	ftsk spoiiie
NIK71_00890	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIK71_00895	COG1280	lysine exporter protein (LysE YggA)
NIK71_00915	COG2894	cell division
NIK71_00930	COG0204	Acyl-transferase
NIK71_00935	COG2885	chlorophyll binding
NIK71_00940	COG0210	DNA helicase
NIK71_00950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIK71_00965	COG0121	glutamine amidotransferase
NIK71_00985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NIK71_00990	COG0735	belongs to the Fur family
NIK71_01015	COG0420	3'-5' exonuclease activity
NIK71_01035	COG1090	epimerase
NIK71_01050	COG2050	protein possibly involved in aromatic compounds catabolism
NIK71_01060	COG2814	Major facilitator Superfamily
NIK71_01065	COG0405	Gamma-glutamyltransferase
NIK71_01100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NIK71_01215	COG1484	DNA-dependent DNA replication
NIK71_01420	COG2026	Addiction module toxin, RelE StbE family
NIK71_01460	COG0592	DNA-directed DNA polymerase activity
NIK71_01595	COG0477	Major facilitator Superfamily
NIK71_01600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIK71_01610	COG1595	DNA-templated transcription, initiation
NIK71_01665	COG0531	amino acid
NIK71_01670	COG2040	homocysteine
NIK71_01695	COG1309	transcriptional regulator
NIK71_01700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NIK71_01705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NIK71_01715	COG1607	acyl-coa hydrolase
NIK71_01725	COG0523	cobalamin synthesis protein
NIK71_01735	COG4681	YaeQ
NIK71_01745	COG0726	polysaccharide deacetylase
NIK71_01745	COG1649	PFAM Uncharacterised BCR, COG1649
NIK71_01750	COG1215	transferase activity, transferring glycosyl groups
NIK71_01760	COG1024	Enoyl-CoA hydratase
NIK71_01775	COG1414	Transcriptional regulator
NIK71_01795	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_01805	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIK71_01810	COG2271	Major facilitator Superfamily
NIK71_01820	COG2267	carboxylic ester hydrolase activity
NIK71_01825	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_01840	COG0028	Belongs to the TPP enzyme family
NIK71_01850	COG0477	Major facilitator Superfamily
NIK71_01855	COG0242	peptide deformylase activity
NIK71_01860	COG2066	Belongs to the glutaminase family
NIK71_01865	COG2207	Transcriptional regulator
NIK71_01870	COG2223	nitrite transmembrane transporter activity
NIK71_01885	COG0583	DNA-binding transcription factor activity
NIK71_01890	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_01895	COG2271	Major facilitator Superfamily
NIK71_01900	COG3959	Transketolase, thiamine diphosphate binding domain
NIK71_01905	COG3958	Transketolase
NIK71_01915	COG0306	phosphate transporter
NIK71_01935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIK71_01980	COG4181	ATPase activity
NIK71_01985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NIK71_02010	COG0583	DNA-binding transcription factor activity
NIK71_02020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIK71_02025	COG1773	rubredoxin
NIK71_02075	COG2851	Citrate transporter
NIK71_02080	COG1253	flavin adenine dinucleotide binding
NIK71_02120	COG0804	urea catabolic process
NIK71_02130	COG0830	nickel cation binding
NIK71_02145	COG0742	ribosomal rna small subunit methyltransferase
NIK71_02150	COG0768	penicillin binding
NIK71_02175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIK71_02180	COG2878	Part of a membrane complex involved in electron transport
NIK71_02185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NIK71_02195	COG3384	dioxygenase
NIK71_02220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NIK71_02430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIK71_02435	COG2011	ABC-type metal ion transport system permease component
NIK71_02440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NIK71_02445	COG1464	Belongs to the NlpA lipoprotein family
NIK71_02450	COG0151	Belongs to the GarS family
NIK71_02455	COG0138	bifunctional purine biosynthesis protein purh
NIK71_02460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NIK71_02490	COG2308	Evidence 4 Homologs of previously reported genes of
NIK71_02500	COG1305	Transglutaminase-like
NIK71_02510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NIK71_02515	COG0305	Participates in initiation and elongation during chromosome replication
NIK71_02540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NIK71_02550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIK71_02555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NIK71_02580	COG1649	PFAM Uncharacterised BCR, COG1649
NIK71_02580	COG0726	polysaccharide deacetylase
NIK71_02585	COG1215	transferase activity, transferring glycosyl groups
NIK71_02600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIK71_02615	COG0583	DNA-binding transcription factor activity
NIK71_02635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIK71_02640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIK71_02660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIK71_02665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIK71_02690	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NIK71_02695	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NIK71_02705	COG2205	protein histidine kinase activity
NIK71_02710	COG0745	RESPONSE REGULATOR receiver
NIK71_02715	COG0174	glutamine synthetase
NIK71_02735	COG0729	surface antigen
NIK71_02760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIK71_02765	COG2814	Major facilitator Superfamily
NIK71_02780	COG0583	DNA-binding transcription factor activity
NIK71_02795	COG1187	pseudouridine synthase activity
NIK71_02815	COG0802	atpase or kinase
NIK71_02820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NIK71_02830	COG1923	regulation of RNA biosynthetic process
NIK71_02835	COG0697	spore germination
NIK71_02850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIK71_02860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIK71_02865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIK71_02865	COG0519	Catalyzes the synthesis of GMP from XMP
NIK71_02870	COG4302	ethanolamine ammonia-lyase activity
NIK71_02875	COG4303	Ethanolamine ammonia lyase large subunit
NIK71_02880	COG0531	amino acid
NIK71_02900	COG1454	alcohol dehydrogenase
NIK71_02905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIK71_02915	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NIK71_02935	COG0308	aminopeptidase N
NIK71_02945	COG4221	oxidoreductase activity
NIK71_02955	COG1605	Chorismate mutase
NIK71_02975	COG1309	transcriptional regulator
NIK71_02990	COG0668	transmembrane transport
NIK71_03025	COG4773	Receptor
NIK71_03045	COG0488	(ABC) transporter
NIK71_03050	COG0589	response to stress
NIK71_03075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIK71_03085	COG3135	benzoate transporter
NIK71_03090	COG1522	sequence-specific DNA binding
NIK71_03100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIK71_03105	COG0583	DNA-binding transcription factor activity
NIK71_03115	COG0183	Belongs to the thiolase family
NIK71_03125	COG2030	dehydratase
NIK71_03130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIK71_03145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIK71_03155	COG0824	Thioesterase
NIK71_03160	COG1454	alcohol dehydrogenase
NIK71_03170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIK71_03190	COG0069	glutamate synthase activity
NIK71_03210	COG2814	Major facilitator Superfamily
NIK71_03225	COG0511	ligase activity, forming carbon-carbon bonds
NIK71_03245	COG1116	anion transmembrane transporter activity
NIK71_03245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIK71_03250	COG0745	RESPONSE REGULATOR receiver
NIK71_03260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIK71_03260	COG2146	nitrite reductase [NAD(P)H] activity
NIK71_03265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIK71_03270	COG0243	molybdopterin cofactor binding
NIK71_03280	COG0243	molybdopterin cofactor binding
NIK71_03285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIK71_03300	COG0521	Mo-molybdopterin cofactor biosynthetic process
NIK71_03300	COG0315	cyclic pyranopterin monophosphate synthase activity
NIK71_03305	COG0303	'Molybdopterin
NIK71_03315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIK71_03320	COG0697	spore germination
NIK71_03340	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NIK71_03345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIK71_03400	COG2204	response regulator
NIK71_03405	COG3852	Histidine kinase
NIK71_03425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIK71_03430	COG0575	Belongs to the CDS family
NIK71_03465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIK71_03480	COG2137	regulation of response to DNA damage stimulus
NIK71_03490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NIK71_03495	COG1011	Hydrolase
NIK71_03520	COG1522	sequence-specific DNA binding
NIK71_03530	COG1113	amino acid transport
NIK71_03550	COG0659	secondary active sulfate transmembrane transporter activity
NIK71_03555	COG2135	peptidase activity
NIK71_03570	COG3300	MHYT domain
NIK71_03570	COG5001	Diguanylate cyclase
NIK71_03590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NIK71_03590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NIK71_03590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NIK71_03595	COG1105	Belongs to the carbohydrate kinase PfkB family
NIK71_03600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIK71_03600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NIK71_03630	COG0024	Methionine aminopeptidase
NIK71_03635	COG0583	DNA-binding transcription factor activity
NIK71_03645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NIK71_03650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIK71_03655	COG0516	GMP reductase activity
NIK71_03655	COG0517	IMP dehydrogenase activity
NIK71_03680	COG0552	protein localization to endoplasmic reticulum
NIK71_03690	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NIK71_03705	COG4890	Cyd operon protein YbgT
NIK71_03710	COG1294	oxidase, subunit
NIK71_03730	COG1585	Membrane protein implicated in regulation of membrane protease activity
NIK71_03740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NIK71_03745	COG4774	siderophore transport
NIK71_03760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NIK71_03765	COG0569	domain protein
NIK71_03770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NIK71_03800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIK71_03805	COG0542	response to heat
NIK71_03830	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIK71_03830	COG1902	pentaerythritol trinitrate reductase activity
NIK71_03875	COG2323	membrane
NIK71_03880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NIK71_03890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NIK71_03895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NIK71_03900	COG0183	Belongs to the thiolase family
NIK71_03905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NIK71_03910	COG0596	Alpha beta hydrolase
NIK71_03915	COG2271	Major facilitator Superfamily
NIK71_03920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIK71_03925	COG3485	protocatechuate 3,4-dioxygenase
NIK71_03930	COG3485	protocatechuate 3,4-dioxygenase
NIK71_03935	COG0710	3-dehydroquinate dehydratase activity
NIK71_03940	COG3420	alginic acid biosynthetic process
NIK71_03945	COG3659	wide pore channel activity
NIK71_03950	COG4993	Dehydrogenase
NIK71_03960	COG2391	methyltransferase activity
NIK71_03975	COG1414	Transcriptional regulator
NIK71_03980	COG0583	DNA-binding transcription factor activity
NIK71_03985	COG1960	acyl-CoA dehydrogenase activity
NIK71_04010	COG2814	Major facilitator Superfamily
NIK71_04020	COG0154	amidase activity
NIK71_04040	COG4638	Rieske (2fe-2S)
NIK71_04050	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_04060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIK71_04070	COG3733	amine oxidase
NIK71_04080	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_04090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIK71_04095	COG0183	Belongs to the thiolase family
NIK71_04100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NIK71_04105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NIK71_04115	COG4829	muconolactone delta-isomerase
NIK71_04120	COG4948	Mandelate Racemase Muconate Lactonizing
NIK71_04125	COG0583	DNA-binding transcription factor activity
NIK71_04135	COG2186	Transcriptional regulator
NIK71_04155	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_04175	COG1960	acyl-CoA dehydrogenase activity
NIK71_04180	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_04185	COG3829	transcription factor binding
NIK71_04195	COG3162	membrane
NIK71_04210	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_04225	COG0753	catalase activity
NIK71_04245	COG1846	Transcriptional regulator
NIK71_04250	COG1902	pentaerythritol trinitrate reductase activity
NIK71_04250	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIK71_04260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIK71_04290	COG1309	transcriptional regulator
NIK71_04300	COG1335	isochorismatase
NIK71_04305	COG0583	DNA-binding transcription factor activity
NIK71_04315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NIK71_04315	COG0475	glutathione-regulated potassium exporter activity
NIK71_04325	COG1473	amidohydrolase
NIK71_04335	COG2831	hemolysin activation secretion protein
NIK71_04340	COG3210	domain, Protein
NIK71_04370	COG2188	Transcriptional regulator
NIK71_04385	COG0583	DNA-binding transcription factor activity
NIK71_04415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NIK71_04445	COG1566	PFAM secretion protein HlyD family protein
NIK71_04460	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_04465	COG0129	dihydroxy-acid dehydratase activity
NIK71_04475	COG0583	DNA-binding transcription factor activity
NIK71_04480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIK71_04490	COG2084	Dehydrogenase
NIK71_04495	COG2207	Transcriptional regulator
NIK71_04510	COG1064	alcohol dehydrogenase
NIK71_04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIK71_04525	COG1120	ATPase activity
NIK71_04545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIK71_04670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIK71_04720	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_04735	COG2207	Transcriptional regulator
NIK71_04745	COG2205	protein histidine kinase activity
NIK71_04750	COG0745	RESPONSE REGULATOR receiver
NIK71_04755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIK71_04760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIK71_04765	COG1538	Outer membrane efflux protein
NIK71_04775	COG2072	flavoprotein involved in K transport
NIK71_04795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIK71_04815	COG3539	Fimbrial protein
NIK71_04845	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NIK71_04855	COG0753	catalase activity
NIK71_04870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NIK71_04930	COG1535	isochorismatase
NIK71_04930	COG3433	isochorismatase activity
NIK71_04935	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_04940	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NIK71_04945	COG4149	molybdate abc transporter
NIK71_04950	COG0725	ABC transporter, periplasmic molybdate-binding protein
NIK71_04960	COG4638	Rieske (2fe-2S)
NIK71_04965	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NIK71_04970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIK71_04970	COG0543	2 iron, 2 sulfur cluster binding
NIK71_04995	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_05010	COG2207	Transcriptional regulator
NIK71_05020	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_05025	COG2610	gluconate transmembrane transporter activity
NIK71_05035	COG0583	DNA-binding transcription factor activity
NIK71_05045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NIK71_05050	COG2031	fatty acid transporter
NIK71_05055	COG0183	Belongs to the thiolase family
NIK71_05060	COG0583	DNA-binding transcription factor activity
NIK71_05065	COG0583	DNA-binding transcription factor activity
NIK71_05080	COG1027	Aspartate ammonia-lyase
NIK71_05090	COG0477	Major facilitator Superfamily
NIK71_05110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIK71_05115	COG4521	taurine ABC transporter
NIK71_05130	COG2188	Transcriptional regulator
NIK71_05140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NIK71_05145	COG1733	regulation of RNA biosynthetic process
NIK71_05150	COG2207	Transcriptional regulator
NIK71_05150	COG3708	Transcriptional regulator
NIK71_05165	COG0730	response to heat
NIK71_05180	COG3453	Protein conserved in bacteria
NIK71_05180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIK71_05190	COG3781	membrane
NIK71_05195	COG1063	alcohol dehydrogenase
NIK71_05205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIK71_05210	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIK71_05215	COG0022	dehydrogenase e1 component
NIK71_05220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIK71_05225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIK71_05240	COG3706	GGDEF domain
NIK71_05255	COG0133	tryptophan synthase activity
NIK71_05265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIK71_05300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NIK71_05325	COG2226	methyltransferase
NIK71_05380	COG0842	Transport permease protein
NIK71_05385	COG0842	Transport permease protein
NIK71_05415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIK71_05420	COG4773	Receptor
NIK71_05440	COG0730	response to heat
NIK71_05445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NIK71_05465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NIK71_05480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIK71_05520	COG4264	IucA IucC family
NIK71_05525	COG4264	IucA IucC family
NIK71_05545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NIK71_05560	COG1960	acyl-CoA dehydrogenase activity
NIK71_05565	COG1960	acyl-CoA dehydrogenase activity
NIK71_05570	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIK71_05575	COG2207	Transcriptional regulator
NIK71_05580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIK71_05585	COG0776	regulation of translation
NIK71_05610	COG0822	iron-sulfur transferase activity
NIK71_05615	COG0316	Belongs to the HesB IscA family
NIK71_05645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NIK71_05665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NIK71_05670	COG0702	epimerase
NIK71_05705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIK71_05715	COG0339	signal peptide processing
NIK71_05765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NIK71_05770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NIK71_05800	COG0776	regulation of translation
NIK71_05865	COG0084	hydrolase, TatD family'
NIK71_05885	COG1663	tetraacyldisaccharide 4'-kinase activity
NIK71_05890	COG1132	(ABC) transporter
NIK71_05900	COG0811	peptide transport
NIK71_05905	COG1475	DNA binding
NIK71_05910	COG1192	Involved in chromosome partitioning
NIK71_05920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIK71_05935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIK71_05940	COG0191	fructose-bisphosphate aldolase activity
NIK71_05960	COG0424	maF-like protein
NIK71_05965	COG2850	peptidyl-arginine hydroxylation
NIK71_05975	COG0640	Transcriptional regulator
NIK71_05985	COG3619	membrane
NIK71_05990	COG3122	Protein conserved in bacteria
NIK71_05995	COG1132	(ABC) transporter
NIK71_06015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NIK71_06020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIK71_06030	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NIK71_06030	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NIK71_06030	COG0506	proline dehydrogenase activity
NIK71_06035	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NIK71_06050	COG3698	Phosphodiester glycosidase
NIK71_06060	COG2353	YceI-like domain
NIK71_06070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NIK71_06115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NIK71_06115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NIK71_06140	COG3539	Fimbrial protein
NIK71_06145	COG3121	Chaperone
NIK71_06170	COG0697	spore germination
NIK71_06180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NIK71_06190	COG0583	DNA-binding transcription factor activity
NIK71_06210	COG1309	transcriptional regulator
NIK71_06230	COG1522	sequence-specific DNA binding
NIK71_06240	COG1126	abc transporter atp-binding protein
NIK71_06245	COG0765	amino acid transport
NIK71_06250	COG0765	amino acid transport
NIK71_06280	COG1464	Belongs to the NlpA lipoprotein family
NIK71_06290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NIK71_06295	COG2011	ABC-type metal ion transport system permease component
NIK71_06300	COG0012	GTP binding
NIK71_06325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NIK71_06365	COG0386	Belongs to the glutathione peroxidase family
NIK71_06375	COG0436	Aminotransferase
NIK71_06415	COG3634	alkyl hydroperoxide reductase activity
NIK71_06430	COG0583	DNA-binding transcription factor activity
NIK71_06435	COG0798	PFAM Bile acid sodium symporter
NIK71_06440	COG0640	Transcriptional regulator
NIK71_06455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NIK71_06465	COG0583	DNA-binding transcription factor activity
NIK71_06475	COG1953	Uracil, thiamine, allantoin
NIK71_06485	COG2175	clavaminate synthase activity
NIK71_06490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIK71_06495	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NIK71_06500	COG4521	taurine ABC transporter
NIK71_06510	COG0477	Major facilitator Superfamily
NIK71_06530	COG1271	oxidase subunit
NIK71_06535	COG1294	oxidase, subunit
NIK71_06545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIK71_06565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIK71_06585	COG3052	prosthetic group binding
NIK71_06590	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NIK71_06600	COG2814	Major facilitator Superfamily
NIK71_06620	COG1346	cytolysis
NIK71_06630	COG0583	DNA-binding transcription factor activity
NIK71_06635	COG0625	glutathione transferase activity
NIK71_06640	COG0625	glutathione transferase activity
NIK71_06645	COG0583	DNA-binding transcription factor activity
NIK71_06660	COG1045	serine acetyltransferase
NIK71_06665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIK71_06670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIK71_06680	COG1280	lysine exporter protein (LysE YggA)
NIK71_06695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIK71_06700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIK71_06705	COG1126	abc transporter atp-binding protein
NIK71_06710	COG0765	amino acid transport
NIK71_06715	COG0765	amino acid transport
NIK71_06735	COG2205	protein histidine kinase activity
NIK71_06735	COG0784	Response regulator, receiver
NIK71_06755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NIK71_06775	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_06825	COG0583	DNA-binding transcription factor activity
NIK71_06845	COG0318	PFAM AMP-dependent synthetase and ligase
NIK71_06850	COG1309	transcriptional regulator
NIK71_06855	COG1960	acyl-CoA dehydrogenase activity
NIK71_06860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NIK71_06865	COG1024	Enoyl-CoA hydratase
NIK71_06870	COG4770	biotin carboxylase activity
NIK71_06880	COG0583	DNA-binding transcription factor activity
NIK71_06895	COG1960	acyl-CoA dehydrogenase activity
NIK71_06905	COG2814	Major facilitator Superfamily
NIK71_06915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NIK71_06920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NIK71_06925	COG2814	Major facilitator Superfamily
NIK71_06930	COG1960	acyl-CoA dehydrogenase activity
NIK71_06935	COG1024	Enoyl-CoA hydratase
NIK71_06940	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_06945	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIK71_06950	COG0183	Belongs to the thiolase family
NIK71_06960	COG2814	Major facilitator Superfamily
NIK71_06970	COG1024	Enoyl-CoA hydratase
NIK71_06985	COG1960	acyl-CoA dehydrogenase activity
NIK71_06990	COG2814	Major facilitator Superfamily
NIK71_06995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIK71_07000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NIK71_07030	COG1840	ABC-type Fe3 transport system, periplasmic component
NIK71_07040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIK71_07045	COG1414	Transcriptional regulator
NIK71_07055	COG0583	DNA-binding transcription factor activity
NIK71_07060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIK71_07065	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_07075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NIK71_07085	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_07090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIK71_07095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIK71_07100	COG2267	carboxylic ester hydrolase activity
NIK71_07120	COG3038	cytochrome b561
NIK71_07125	COG0753	catalase activity
NIK71_07160	COG2050	protein possibly involved in aromatic compounds catabolism
NIK71_07170	COG3327	negative regulation of DNA-templated transcription, initiation
NIK71_07175	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NIK71_07180	COG0183	Belongs to the thiolase family
NIK71_07185	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIK71_07190	COG1024	Enoyl-CoA hydratase
NIK71_07195	COG1024	Enoyl-CoA hydratase
NIK71_07200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIK71_07205	COG2151	metal-sulfur cluster biosynthetic enzyme
NIK71_07210	COG3396	Phenylacetate-CoA oxygenase
NIK71_07215	COG3460	Phenylacetate-CoA oxygenase
NIK71_07220	COG3396	Phenylacetate-CoA oxygenase
NIK71_07225	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_07225	COG2030	dehydratase
NIK71_07230	COG1760	l-serine dehydratase
NIK71_07235	COG0531	amino acid
NIK71_07240	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_07255	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIK71_07265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIK71_07285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIK71_07295	COG0789	Transcriptional regulator
NIK71_07315	COG1116	anion transmembrane transporter activity
NIK71_07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIK71_07330	COG0864	Transcriptional regulator
NIK71_07350	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIK71_07355	COG0439	Biotin carboxylase
NIK71_07370	COG1063	alcohol dehydrogenase
NIK71_07380	COG1309	transcriptional regulator
NIK71_07400	COG0038	chloride channel
NIK71_07405	COG4770	biotin carboxylase activity
NIK71_07425	COG1914	H( )-stimulated, divalent metal cation uptake system
NIK71_07430	COG0583	DNA-binding transcription factor activity
NIK71_07480	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIK71_07500	COG2814	Major facilitator Superfamily
NIK71_07515	COG1560	Kdo2-lipid A biosynthetic process
NIK71_07525	COG5006	permease, DMT superfamily
NIK71_07530	COG1522	sequence-specific DNA binding
NIK71_07545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NIK71_07555	COG4122	O-methyltransferase activity
NIK71_07585	COG1538	Outer membrane efflux protein
NIK71_07590	COG1137	ATPase activity
NIK71_07595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NIK71_07605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NIK71_07610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NIK71_07610	COG0517	IMP dehydrogenase activity
NIK71_07650	COG2814	Major facilitator Superfamily
NIK71_07685	COG1278	Cold shock
NIK71_07690	COG1280	lysine exporter protein (LysE YggA)
NIK71_07720	COG1570	exodeoxyribonuclease VII activity
NIK71_07770	COG0583	DNA-binding transcription factor activity
NIK71_07780	COG4638	Rieske (2fe-2S)
NIK71_07785	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NIK71_07790	COG0543	2 iron, 2 sulfur cluster binding
NIK71_07790	COG0633	Ferredoxin
NIK71_07795	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_07800	COG3135	benzoate transporter
NIK71_07805	COG2814	Major facilitator Superfamily
NIK71_07820	COG1643	Atp-dependent helicase
NIK71_07825	COG0450	alkyl hydroperoxide reductase
NIK71_07835	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NIK71_07845	COG3634	alkyl hydroperoxide reductase activity
NIK71_07865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NIK71_07870	COG0625	glutathione transferase activity
NIK71_07880	COG2885	chlorophyll binding
NIK71_07915	COG0542	response to heat
NIK71_07930	COG1765	OsmC-like protein
NIK71_07950	COG0667	Aldo Keto reductase
NIK71_07965	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NIK71_07975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NIK71_07985	COG0527	aspartate kinase activity
NIK71_07995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NIK71_08005	COG3038	cytochrome b561
NIK71_08010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NIK71_08015	COG2252	PERMEase
NIK71_08025	COG2072	flavoprotein involved in K transport
NIK71_08040	COG1741	Belongs to the pirin family
NIK71_08045	COG1309	transcriptional regulator
NIK71_08055	COG0300	oxidoreductase activity
NIK71_08070	COG3209	COG3209 Rhs family protein
NIK71_08100	COG4269	membrane
NIK71_08115	COG1902	pentaerythritol trinitrate reductase activity
NIK71_08115	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIK71_08125	COG5001	Diguanylate cyclase
NIK71_08125	COG4251	negative regulation of phosphorylation
NIK71_08125	COG3706	GGDEF domain
NIK71_08125	COG2203	Gaf domain
NIK71_08135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NIK71_08155	COG4172	Belongs to the ABC transporter superfamily
NIK71_08160	COG4239	(ABC) transporter, permease
NIK71_08165	COG4174	ABC transporter (Permease)
NIK71_08175	COG1388	LysM domain
NIK71_08175	COG0741	lytic transglycosylase activity
NIK71_08175	COG1388	LysM domain
NIK71_08175	COG0741	lytic transglycosylase activity
NIK71_08180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NIK71_08220	COG0583	DNA-binding transcription factor activity
NIK71_08225	COG1279	arginine transmembrane transporter activity
NIK71_08245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIK71_08250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIK71_08255	COG0006	proline dipeptidase activity
NIK71_08295	COG2194	sulfuric ester hydrolase activity
NIK71_08340	COG0739	heme binding
NIK71_08540	COG1794	racemase activity, acting on amino acids and derivatives
NIK71_08550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NIK71_08550	COG3008	intermembrane lipid transfer
NIK71_08555	COG2995	paraquat-inducible protein a
NIK71_08565	COG2985	domain, Protein
NIK71_08595	COG0477	Major facilitator Superfamily
NIK71_08645	COG2186	Transcriptional regulator
NIK71_08655	COG0786	glutamate:sodium symporter activity
NIK71_08660	COG3243	poly(R)-hydroxyalkanoic acid synthase
NIK71_08685	COG3111	PFAM Bacterial OB fold (BOF) protein
NIK71_08785	COG1610	YqeY-like protein
NIK71_08790	COG4783	chaperone-mediated protein folding
NIK71_08815	COG1286	toxin biosynthetic process
NIK71_08845	COG0778	Nitroreductase
NIK71_08855	COG0513	Belongs to the DEAD box helicase family
NIK71_08880	COG2363	Small membrane protein
NIK71_08910	COG1234	tRNA 3'-trailer cleavage
NIK71_08915	COG2195	Cleaves the N-terminal amino acid of tripeptides
NIK71_08925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NIK71_08935	COG2819	hydrolase of the alpha beta superfamily
NIK71_08940	COG1960	acyl-CoA dehydrogenase activity
NIK71_08945	COG1301	dicarboxylic acid transport
NIK71_08950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIK71_08955	COG3139	Protein of unknown function (DUF1315)
NIK71_08960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIK71_08965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NIK71_08975	COG0494	nUDIX hydrolase
NIK71_08985	COG0642	Histidine kinase
NIK71_09000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NIK71_09010	COG1720	tRNA m6t6A37 methyltransferase activity
NIK71_09025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIK71_09030	COG0826	peptidase U32
NIK71_09035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIK71_09045	COG4598	ABC transporter
NIK71_09050	COG4160	amino acid transport
NIK71_09055	COG4215	(ABC) transporter
NIK71_09070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIK71_09115	COG1131	(ABC) transporter
NIK71_09120	COG0842	Transport permease protein
NIK71_09135	COG0772	Belongs to the SEDS family
NIK71_09140	COG2951	lytic endotransglycosylase activity
NIK71_09165	COG2207	Transcriptional regulator
NIK71_09180	COG0052	Belongs to the universal ribosomal protein uS2 family
NIK71_09185	COG0024	Methionine aminopeptidase
NIK71_09195	COG2223	nitrite transmembrane transporter activity
NIK71_09205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIK71_09210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIK71_09215	COG1960	acyl-CoA dehydrogenase activity
NIK71_09230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NIK71_09235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NIK71_09240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NIK71_09260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIK71_09265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NIK71_09270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NIK71_09305	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIK71_09315	COG0174	glutamine synthetase
NIK71_09330	COG0582	viral genome integration into host DNA
NIK71_09385	COG1598	PFAM Uncharacterised protein family UPF0150
NIK71_09770	COG0739	heme binding
NIK71_09900	COG5410	chromosome segregation
NIK71_10105	COG0512	Glutamine amidotransferase of anthranilate synthase
NIK71_10110	COG0308	aminopeptidase N
NIK71_10140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIK71_10150	COG0302	gtp cyclohydrolase
NIK71_10175	COG3739	integral membrane protein
NIK71_10190	COG1169	isochorismate synthase
NIK71_10200	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NIK71_10205	COG1132	(ABC) transporter
NIK71_10210	COG1132	(ABC) transporter
NIK71_10225	COG3433	isochorismatase activity
NIK71_10225	COG1535	isochorismatase
NIK71_10230	COG1021	2,3-dihydroxybenzoate-AMP ligase
NIK71_10235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIK71_10245	COG4774	siderophore transport
NIK71_10250	COG4607	ABC-type enterochelin transport system periplasmic component
NIK71_10255	COG4604	ABC transporter, ATP-binding protein
NIK71_10260	COG4605	iron ion homeostasis
NIK71_10265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIK71_10270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIK71_10285	COG2964	Protein conserved in bacteria
NIK71_10325	COG1309	transcriptional regulator
NIK71_10335	COG4948	Mandelate Racemase Muconate Lactonizing
NIK71_10340	COG2814	Major facilitator Superfamily
NIK71_10375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIK71_10375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NIK71_10380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIK71_10390	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_10400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NIK71_10405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NIK71_10410	COG0583	DNA-binding transcription factor activity
NIK71_10415	COG1113	amino acid transport
NIK71_10435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NIK71_10435	COG2508	Transcriptional regulator
NIK71_10470	COG2879	small protein
NIK71_10475	COG1966	Carbon starvation protein
NIK71_10520	COG1067	ATP-dependent peptidase activity
NIK71_10525	COG0583	DNA-binding transcription factor activity
NIK71_10550	COG1686	Belongs to the peptidase S11 family
NIK71_10555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIK71_10590	COG0616	signal peptide processing
NIK71_10595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NIK71_10605	COG0573	inorganic phosphate transmembrane transporter activity
NIK71_10610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIK71_10615	COG1113	amino acid transport
NIK71_10620	COG3961	Belongs to the TPP enzyme family
NIK71_10625	COG1522	sequence-specific DNA binding
NIK71_10635	COG0076	glutamate decarboxylase activity
NIK71_10640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NIK71_10650	COG1309	transcriptional regulator
NIK71_10665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIK71_10700	COG0352	thiamine-phosphate diphosphorylase activity
NIK71_10725	COG0612	Peptidase, M16
NIK71_10735	COG1823	symporter activity
NIK71_10740	COG0583	DNA-binding transcription factor activity
NIK71_10745	COG0477	Major facilitator Superfamily
NIK71_10770	COG1187	pseudouridine synthase activity
NIK71_10785	COG1686	Belongs to the peptidase S11 family
NIK71_10790	COG1252	NADH dehydrogenase
NIK71_10800	COG0415	Belongs to the DNA photolyase family
NIK71_10815	COG1215	transferase activity, transferring glycosyl groups
NIK71_10845	COG2070	2-Nitropropane dioxygenase
NIK71_10900	COG0556	nucleotide-excision repair
NIK71_10920	COG0436	Aminotransferase
NIK71_10950	COG4221	oxidoreductase activity
NIK71_10960	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NIK71_10965	COG1381	Involved in DNA repair and RecF pathway recombination
NIK71_10975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NIK71_10990	COG0681	Belongs to the peptidase S26 family
NIK71_11005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIK71_11025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NIK71_11030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NIK71_11035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NIK71_11045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NIK71_11050	COG4208	sulfate ABC transporter
NIK71_11055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIK71_11060	COG0583	DNA-binding transcription factor activity
NIK71_11065	COG4625	pathogenesis
NIK71_11080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NIK71_11095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIK71_11105	COG1051	belongs to the nudix hydrolase family
NIK71_11105	COG1056	cytidyltransferase-related domain
NIK71_11110	COG1024	Enoyl-CoA hydratase
NIK71_11125	COG2814	Major facilitator Superfamily
NIK71_11130	COG0047	phosphoribosylformylglycinamidine synthase activity
NIK71_11130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIK71_11150	COG1473	amidohydrolase
NIK71_11155	COG0824	Thioesterase
NIK71_11175	COG0823	Involved in the tonB-independent uptake of proteins
NIK71_11195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIK71_11235	COG0628	permease
NIK71_11245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NIK71_11250	COG0596	Alpha beta hydrolase
NIK71_11255	COG0616	signal peptide processing
NIK71_11255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIK71_11265	COG0658	competence protein
NIK71_11265	COG2333	competence protein COMEC
NIK71_11270	COG1136	(ABC) transporter
NIK71_11275	COG4591	ABC-type transport system involved in lipoprotein release permease component
NIK71_11310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIK71_11330	COG0463	Glycosyl transferase, family 2
NIK71_11360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NIK71_11365	COG1280	lysine exporter protein (LysE YggA)
NIK71_11375	COG0019	diaminopimelate decarboxylase activity
NIK71_11385	COG1113	amino acid transport
NIK71_11400	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NIK71_11410	COG3339	Conserved Protein
NIK71_11415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NIK71_11420	COG0243	molybdopterin cofactor binding
NIK71_11425	COG1929	Belongs to the glycerate kinase type-1 family
NIK71_11440	COG0778	Nitroreductase
NIK71_11535	COG4397	Mu-like prophage major head subunit gpT
NIK71_11550	COG5005	Phage virion morphogenesis
NIK71_11555	COG2369	cell adhesion
NIK71_11560	COG4383	Mu-like prophage protein gp29
NIK71_11575	COG4373	Mu-like prophage FluMu protein gp28
NIK71_11610	COG0681	Belongs to the peptidase S26 family
NIK71_11640	COG3409	Peptidoglycan-binding domain 1 protein
NIK71_11640	COG3267	Type II secretory pathway component ExeA
NIK71_11720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIK71_11735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NIK71_11755	COG0741	lytic transglycosylase activity
NIK71_11775	COG0584	glycerophosphoryl diester phosphodiesterase
NIK71_11805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NIK71_11810	COG1597	lipid kinase activity
NIK71_11825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NIK71_11830	COG0477	Major facilitator Superfamily
NIK71_11880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NIK71_11885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIK71_11910	COG0505	Belongs to the CarA family
NIK71_11930	COG0589	response to stress
NIK71_11945	COG2843	Capsule synthesis protein
NIK71_11965	COG2321	neutral zinc metallopeptidase
NIK71_11970	COG2354	Protein conserved in bacteria
NIK71_11990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIK71_12015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NIK71_12020	COG1053	succinate dehydrogenase
NIK71_12025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NIK71_12030	COG2009	succinate dehydrogenase
NIK71_12070	COG2921	Belongs to the UPF0250 family
NIK71_12075	COG0321	lipoyl(octanoyl) transferase activity
NIK71_12090	COG0531	amino acid
NIK71_12100	COG1733	regulation of RNA biosynthetic process
NIK71_12105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NIK71_12110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIK71_12110	COG1648	precorrin-2 dehydrogenase activity
NIK71_12125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NIK71_12155	COG0671	phosphoesterase, PA-phosphatase related
NIK71_12160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIK71_12170	COG1538	Outer membrane efflux protein
NIK71_12175	COG0393	Putative heavy-metal-binding
NIK71_12180	COG0393	Putative heavy-metal-binding
NIK71_12190	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_12200	COG0525	valine-tRNA ligase activity
NIK71_12220	COG0583	DNA-binding transcription factor activity
NIK71_12225	COG0004	ammonium transporteR
NIK71_12235	COG0642	Histidine kinase
NIK71_12240	COG0745	RESPONSE REGULATOR receiver
NIK71_12245	COG2194	sulfuric ester hydrolase activity
NIK71_12265	COG1752	Esterase of the alpha-beta hydrolase superfamily
NIK71_12280	COG2315	Protein conserved in bacteria
NIK71_12285	COG0142	geranyltranstransferase activity
NIK71_12290	COG2828	Protein conserved in bacteria
NIK71_12295	COG1113	amino acid transport
NIK71_12315	COG2207	Transcriptional regulator
NIK71_12340	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIK71_12350	COG0560	Phosphoserine phosphatase
NIK71_12360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIK71_12370	COG1530	ribonuclease E activity
NIK71_12375	COG0424	maF-like protein
NIK71_12380	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NIK71_12385	COG1792	Involved in formation and maintenance of cell shape
NIK71_12390	COG1077	Cell shape determining protein MreB Mrl
NIK71_12395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIK71_12405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIK71_12435	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NIK71_12440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NIK71_12445	COG1752	Esterase of the alpha-beta hydrolase superfamily
NIK71_12450	COG1115	amino acid carrier protein
NIK71_12470	COG2814	Major facilitator Superfamily
NIK71_12475	COG1289	transmembrane transporter activity
NIK71_12485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIK71_12525	COG1376	ErfK ybiS ycfS ynhG family protein
NIK71_12530	COG2832	Protein of unknown function (DUF454)
NIK71_12540	COG5510	response to toxic substance
NIK71_12560	COG0840	transmembrane signaling receptor activity
NIK71_12600	COG3422	double-strand break repair
NIK71_12605	COG2824	Alkylphosphonate utilization operon protein PhnA
NIK71_12610	COG3189	MarR family transcriptional regulator
NIK71_12620	COG0354	folic acid binding
NIK71_12625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIK71_12635	COG0679	Auxin Efflux Carrier
NIK71_12640	COG1902	pentaerythritol trinitrate reductase activity
NIK71_12660	COG2094	Belongs to the DNA glycosylase MPG family
NIK71_12685	COG1217	gtp-binding protein TYPA
NIK71_12690	COG2233	PERMEase
NIK71_12700	COG0833	amino acid
NIK71_12705	COG1690	Belongs to the RtcB family
NIK71_12715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIK71_12715	COG2885	chlorophyll binding
NIK71_12725	COG0183	Belongs to the thiolase family
NIK71_12745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIK71_12765	COG2207	Transcriptional regulator
NIK71_12770	COG0183	Belongs to the thiolase family
NIK71_12800	COG1272	protein, Hemolysin III
NIK71_12805	COG0477	Major facilitator Superfamily
NIK71_12820	COG0450	alkyl hydroperoxide reductase
NIK71_12840	COG0285	dihydrofolate synthase activity
NIK71_12890	COG2096	Adenosyltransferase
NIK71_12910	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NIK71_12915	COG0745	RESPONSE REGULATOR receiver
NIK71_12920	COG2205	protein histidine kinase activity
NIK71_12930	COG1960	acyl-CoA dehydrogenase activity
NIK71_12935	COG1960	acyl-CoA dehydrogenase activity
NIK71_12940	COG0583	DNA-binding transcription factor activity
NIK71_12945	COG0625	glutathione transferase activity
NIK71_13010	COG0438	transferase activity, transferring glycosyl groups
NIK71_13015	COG0463	Glycosyl transferase, family 2
NIK71_13020	COG0726	polysaccharide deacetylase
NIK71_13040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NIK71_13045	COG2205	protein histidine kinase activity
NIK71_13075	COG1862	Preprotein translocase
NIK71_13085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIK71_13090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NIK71_13100	COG3781	membrane
NIK71_13105	COG0613	PHP domain protein
NIK71_13115	COG2350	Protein conserved in bacteria
NIK71_13145	COG1607	acyl-coa hydrolase
NIK71_13205	COG2199	diguanylate cyclase activity
NIK71_13215	COG1408	metallophosphoesterase
NIK71_13220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NIK71_13230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NIK71_13250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NIK71_13255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIK71_13270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NIK71_13280	COG2969	positive regulation of protein catabolic process
NIK71_13300	COG1960	acyl-CoA dehydrogenase activity
NIK71_13305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NIK71_13320	COG1309	transcriptional regulator
NIK71_13325	COG1960	acyl-CoA dehydrogenase activity
NIK71_13370	COG1183	phosphatidylcholine synthase activity
NIK71_13375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NIK71_13405	COG0739	heme binding
NIK71_13405	COG0741	lytic transglycosylase activity
NIK71_13405	COG1196	nuclear chromosome segregation
NIK71_13415	COG1702	phosphate starvation-inducible protein PhoH
NIK71_13450	COG1295	ribonuclease BN
NIK71_13455	COG0697	spore germination
NIK71_13460	COG2169	Transcriptional regulator
NIK71_13465	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIK71_13515	COG0557	exoribonuclease II activity
NIK71_13520	COG0339	signal peptide processing
NIK71_13525	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NIK71_13555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NIK71_13560	COG1960	acyl-CoA dehydrogenase activity
NIK71_13715	COG0626	cystathionine gamma-synthase activity
NIK71_13720	COG0433	COG0433 Predicted ATPase
NIK71_13725	COG1017	nitric oxide dioxygenase activity
NIK71_13725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIK71_13730	COG1959	2 iron, 2 sulfur cluster binding
NIK71_13745	COG1301	dicarboxylic acid transport
NIK71_13750	COG1946	Acyl-CoA thioesterase
NIK71_13770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIK71_13775	COG1040	competence protein
NIK71_13780	COG0494	nUDIX hydrolase
NIK71_13790	COG0598	Magnesium transport protein CorA
NIK71_13800	COG2854	intermembrane phospholipid transfer
NIK71_13810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIK71_13815	COG1127	ABC transporter
NIK71_13825	COG0513	Belongs to the DEAD box helicase family
NIK71_13845	COG0408	coproporphyrinogen oxidase activity
NIK71_13860	COG1960	acyl-CoA dehydrogenase activity
NIK71_13870	COG1983	PspC domain protein
NIK71_13875	COG0517	IMP dehydrogenase activity
NIK71_13920	COG0583	DNA-binding transcription factor activity
NIK71_13960	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_13970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIK71_13975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NIK71_13980	COG0833	amino acid
NIK71_14010	COG1192	Involved in chromosome partitioning
NIK71_14015	COG0628	permease
NIK71_14025	COG1289	transmembrane transporter activity
NIK71_14040	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIK71_14045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NIK71_14055	COG0277	FAD linked oxidase domain protein
NIK71_14060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIK71_14085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NIK71_14090	COG5380	lipid catabolic process
NIK71_14110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NIK71_14160	COG0194	GDP metabolic process
NIK71_14175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIK71_14195	COG3307	-O-antigen
NIK71_14215	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NIK71_14220	COG1704	LemA family
NIK71_14230	COG0493	'glutamate synthase
NIK71_14235	COG0067	glutamate synthase
NIK71_14235	COG0069	glutamate synthase activity
NIK71_14235	COG0070	glutamate synthase
NIK71_14285	COG2226	methyltransferase
NIK71_14300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NIK71_14305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIK71_14350	COG0833	amino acid
NIK71_14435	COG0488	(ABC) transporter
NIK71_14440	COG2873	o-acetylhomoserine
NIK71_14445	COG4221	oxidoreductase activity
NIK71_14450	COG0659	secondary active sulfate transmembrane transporter activity
NIK71_14475	COG0427	acetyl-CoA hydrolase
NIK71_14505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NIK71_14535	COG2329	Antibiotic biosynthesis monooxygenase
NIK71_14550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NIK71_14615	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIK71_14620	COG1733	regulation of RNA biosynthetic process
NIK71_14655	COG0667	Aldo Keto reductase
NIK71_14675	COG0583	DNA-binding transcription factor activity
NIK71_14680	COG2814	Major facilitator Superfamily
NIK71_14710	COG1335	isochorismatase
NIK71_14720	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_14725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NIK71_14735	COG1113	amino acid transport
NIK71_14745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NIK71_14760	COG2814	Major facilitator Superfamily
NIK71_14770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NIK71_14770	COG0352	thiamine-phosphate diphosphorylase activity
NIK71_14770	COG0351	phosphomethylpyrimidine kinase
NIK71_14790	COG1309	transcriptional regulator
NIK71_14795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NIK71_14815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NIK71_14825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIK71_14830	COG3162	membrane
NIK71_14835	COG0784	Response regulator, receiver
NIK71_14835	COG2198	Histidine kinase
NIK71_14835	COG2205	protein histidine kinase activity
NIK71_14860	COG3328	transposase activity
NIK71_14865	COG1522	sequence-specific DNA binding
NIK71_14870	COG1335	isochorismatase
NIK71_14875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIK71_14885	COG0668	transmembrane transport
NIK71_14890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NIK71_14895	COG1519	Transferase
NIK71_14900	COG1902	pentaerythritol trinitrate reductase activity
NIK71_14920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIK71_14945	COG0426	domain, Protein
NIK71_14945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIK71_14950	COG4774	siderophore transport
NIK71_14955	COG2119	membrane
NIK71_14965	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIK71_14975	COG4942	peptidase
NIK71_14990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NIK71_15000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NIK71_15020	COG0189	ligase activity
NIK71_15040	COG0708	Exodeoxyribonuclease III
NIK71_15045	COG1393	Belongs to the ArsC family
NIK71_15060	COG3706	GGDEF domain
NIK71_15095	COG2351	hydroxyisourate hydrolase activity
NIK71_15100	COG2233	PERMEase
NIK71_15110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIK71_15120	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NIK71_15125	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_15135	COG3150	esterase
NIK71_15150	COG1388	LysM domain
NIK71_15150	COG0791	NLP P60 protein
NIK71_15165	COG2918	glutathione biosynthetic process
NIK71_15180	COG2733	membrane
NIK71_15185	COG0436	Aminotransferase
NIK71_15190	COG0534	Mate efflux family protein
NIK71_15290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NIK71_15295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NIK71_15305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NIK71_15310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NIK71_15325	COG0010	Belongs to the arginase family
NIK71_15355	COG2188	Transcriptional regulator
NIK71_15365	COG0523	cobalamin synthesis protein
NIK71_15375	COG1113	amino acid transport
NIK71_15385	COG0625	glutathione transferase activity
NIK71_15405	COG1683	Conserved Protein
NIK71_15410	COG0534	Mate efflux family protein
NIK71_15415	COG0385	Bile acid
NIK71_15420	COG1335	isochorismatase
NIK71_15425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIK71_15445	COG2116	formate transmembrane transporter activity
NIK71_15450	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NIK71_15455	COG2133	pyrroloquinoline quinone binding
NIK71_15460	COG2983	Belongs to the UPF0260 family
NIK71_15480	COG1194	a g-specific adenine glycosylase
NIK71_15495	COG2818	Glycosylase
NIK71_15500	COG1064	alcohol dehydrogenase
NIK71_15505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIK71_15520	COG0583	DNA-binding transcription factor activity
NIK71_15525	COG0656	L-ascorbic acid biosynthetic process
NIK71_15530	COG2814	Major facilitator Superfamily
NIK71_15565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIK71_15580	COG2233	PERMEase
NIK71_15670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NIK71_15675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NIK71_15680	COG0596	Alpha beta hydrolase
NIK71_15705	COG0488	(ABC) transporter
NIK71_15710	COG0586	Pfam SNARE associated Golgi protein
NIK71_15720	COG0187	DNA topoisomerase II activity
NIK71_15730	COG0592	DNA-directed DNA polymerase activity
NIK71_15755	COG0706	membrane insertase activity
NIK71_15770	COG1230	cation diffusion facilitator family transporter
NIK71_15775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIK71_15790	COG0402	S-adenosylhomocysteine deaminase activity
NIK71_15800	COG0754	glutathionylspermidine amidase activity
NIK71_15810	COG0861	Integral membrane protein TerC family
NIK71_15815	COG0671	phosphoesterase, PA-phosphatase related
NIK71_15825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIK71_15840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NIK71_15845	COG2951	lytic endotransglycosylase activity
NIK71_15880	COG0583	DNA-binding transcription factor activity
NIK71_15900	COG0657	acetylesterase activity
NIK71_15905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIK71_15945	COG1047	Peptidyl-prolyl cis-trans
NIK71_15955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NIK71_15960	COG0196	riboflavin kinase activity
NIK71_15970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NIK71_15975	COG1309	transcriptional regulator
NIK71_15980	COG1116	anion transmembrane transporter activity
NIK71_15985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIK71_15990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIK71_15995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIK71_16000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIK71_16020	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_16025	COG0546	phosphoglycolate phosphatase activity
NIK71_16085	COG3023	N-Acetylmuramoyl-L-alanine amidase
NIK71_16090	COG0728	peptidoglycan biosynthetic process
NIK71_16120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NIK71_16125	COG1086	Polysaccharide biosynthesis protein
NIK71_16130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIK71_16135	COG1083	cytidylyl-transferase
NIK71_16150	COG2089	acid synthase
NIK71_16155	COG2244	polysaccharide biosynthetic process
NIK71_16175	COG1216	Glycosyl transferase, family 2
NIK71_16180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIK71_16185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NIK71_16200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIK71_16205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIK71_16215	COG2186	Transcriptional regulator
NIK71_16225	COG0277	FAD linked oxidase domain protein
NIK71_16230	COG1448	Aminotransferase
NIK71_16240	COG1802	Transcriptional regulator
NIK71_16255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NIK71_16275	COG1051	belongs to the nudix hydrolase family
NIK71_16310	COG0564	pseudouridine synthase activity
NIK71_16350	COG0251	oxidation-reduction process
NIK71_16355	COG1113	amino acid transport
NIK71_16360	COG1113	amino acid transport
NIK71_16380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIK71_16385	COG1960	acyl-CoA dehydrogenase activity
NIK71_16390	COG1024	Enoyl-CoA hydratase
NIK71_16395	COG1024	Enoyl-CoA hydratase
NIK71_16400	COG0477	Major facilitator Superfamily
NIK71_16405	COG3916	Acyl-homoserine-lactone synthase
NIK71_16415	COG2197	response regulator
NIK71_16430	COG1960	acyl-CoA dehydrogenase activity
NIK71_16435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIK71_16435	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NIK71_16435	COG3321	synthase
NIK71_16435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIK71_16455	COG2267	carboxylic ester hydrolase activity
NIK71_16475	COG0271	Belongs to the BolA IbaG family
NIK71_16485	COG1192	Involved in chromosome partitioning
NIK71_16500	COG0586	Pfam SNARE associated Golgi protein
NIK71_16505	COG2259	Doxx family
NIK71_16510	COG4399	Belongs to the UPF0754 family
NIK71_16515	COG0519	Catalyzes the synthesis of GMP from XMP
NIK71_16515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIK71_16560	COG0281	malic enzyme
NIK71_16570	COG2837	iron assimilation
NIK71_16575	COG1280	lysine exporter protein (LysE YggA)
NIK71_16580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIK71_16585	COG1121	(ABC) transporter
NIK71_16650	COG0386	Belongs to the glutathione peroxidase family
NIK71_16665	COG1309	transcriptional regulator
NIK71_16670	COG0697	spore germination
NIK71_16680	COG0758	DNA mediated transformation
NIK71_16750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIK71_16760	COG0655	NAD(P)H dehydrogenase (quinone) activity
NIK71_16800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIK71_16820	COG1253	flavin adenine dinucleotide binding
NIK71_16830	COG2860	membrane
NIK71_16835	COG0477	Major facilitator Superfamily
NIK71_16845	COG0318	PFAM AMP-dependent synthetase and ligase
NIK71_16860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NIK71_16880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIK71_16890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIK71_16925	COG0589	response to stress
NIK71_16930	COG0659	secondary active sulfate transmembrane transporter activity
NIK71_16950	COG0347	Belongs to the P(II) protein family
NIK71_16955	COG0004	ammonium transporteR
NIK71_16965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIK71_16965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIK71_17005	COG0795	lipopolysaccharide-transporting ATPase activity
NIK71_17010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NIK71_17015	COG0793	Belongs to the peptidase S41A family
NIK71_17030	COG2197	response regulator
NIK71_17040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIK71_17050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIK71_17055	COG4974	Belongs to the 'phage' integrase family
NIK71_17080	COG0772	Belongs to the SEDS family
NIK71_17085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIK71_17090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NIK71_17095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NIK71_17120	COG0697	spore germination
NIK71_17125	COG1538	Outer membrane efflux protein
NIK71_17145	COG3275	phosphorelay sensor kinase activity
NIK71_17155	COG0181	hydroxymethylbilane synthase activity
NIK71_17200	COG1716	ATPase activity
NIK71_17205	COG0546	phosphoglycolate phosphatase activity
NIK71_17300	COG0596	Alpha beta hydrolase
NIK71_17305	COG2056	Na+-H+ antiporter family
NIK71_17320	COG0326	Molecular chaperone. Has ATPase activity
NIK71_17335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NIK71_17410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NIK71_17415	COG2169	Transcriptional regulator
NIK71_17415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NIK71_17445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NIK71_17455	COG0497	DNA recombination
NIK71_17470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIK71_17480	COG0237	dephospho-CoA kinase activity
NIK71_17485	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NIK71_17535	COG0195	Participates in both transcription termination and antitermination
NIK71_17550	COG1320	monovalent cation:proton antiporter activity
NIK71_17555	COG2212	antiporter activity
NIK71_17560	COG1863	multisubunit Na H antiporter MnhE subunit
NIK71_17565	COG0651	ATP synthesis coupled electron transport
NIK71_17570	COG1006	Multisubunit Na H antiporter MnhC subunit
NIK71_17575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIK71_17575	COG2111	Na H antiporter
NIK71_17590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NIK71_17595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIK71_17610	COG2226	methyltransferase
NIK71_17630	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NIK71_17635	COG1074	ATP-dependent DNA helicase activity
NIK71_17640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIK71_17645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIK71_17660	COG0598	Magnesium transport protein CorA
NIK71_17665	COG0789	Transcriptional regulator
NIK71_17670	COG0484	heat shock protein binding
NIK71_17680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NIK71_17685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NIK71_17685	COG0475	glutathione-regulated potassium exporter activity
NIK71_17690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NIK71_17710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIK71_17720	COG4535	Mg2 and Co2 transporter CorC
NIK71_17725	COG0425	Belongs to the sulfur carrier protein TusA family
NIK71_17730	COG0644	oxidoreductase
NIK71_17730	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NIK71_17740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NIK71_17755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIK71_17760	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NIK71_17800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIK71_17815	COG0534	Mate efflux family protein
NIK71_17825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIK71_17830	COG4221	oxidoreductase activity
NIK71_17835	COG0583	DNA-binding transcription factor activity
NIK71_17850	COG0318	PFAM AMP-dependent synthetase and ligase
NIK71_17855	COG1530	ribonuclease E activity
NIK71_17865	COG0546	phosphoglycolate phosphatase activity
NIK71_17870	COG2378	regulation of single-species biofilm formation
NIK71_17875	COG0625	glutathione transferase activity
NIK71_17885	COG0583	DNA-binding transcription factor activity
NIK71_17950	COG0473	3-isopropylmalate dehydrogenase activity
NIK71_18005	COG1301	dicarboxylic acid transport
NIK71_18015	COG1560	Kdo2-lipid A biosynthetic process
NIK71_18020	COG1280	lysine exporter protein (LysE YggA)
NIK71_18025	COG0488	(ABC) transporter
NIK71_18030	COG2900	Belongs to the SlyX family
NIK71_18040	COG1733	regulation of RNA biosynthetic process
NIK71_18065	COG0210	DNA helicase
NIK71_18070	COG0724	RNA recognition motif
NIK71_18090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NIK71_18090	COG4651	solute:proton antiporter activity
NIK71_18115	COG0788	formyltetrahydrofolate deformylase activity
NIK71_18215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIK71_18215	COG2813	Specifically methylates the guanine in position
NIK71_18225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIK71_18235	COG4774	siderophore transport
NIK71_18245	COG0740	serine-type endopeptidase activity
NIK71_18265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NIK71_18265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NIK71_18270	COG0857	belongs to the CobB CobQ family
NIK71_18270	COG0280	phosphate acetyltransferase
NIK71_18275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NIK71_18285	COG0800	Aldolase
NIK71_18295	COG3265	gluconokinase activity
NIK71_18300	COG1012	belongs to the aldehyde dehydrogenase family
NIK71_18310	COG2267	carboxylic ester hydrolase activity
NIK71_18325	COG0793	Belongs to the peptidase S41A family
NIK71_18360	COG1426	Protein conserved in bacteria
NIK71_18405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIK71_18415	COG0318	PFAM AMP-dependent synthetase and ligase
NIK71_18430	COG2986	histidine ammonia-lyase
NIK71_18470	COG1028	Short-chain dehydrogenase reductase Sdr
NIK71_18475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIK71_18495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIK71_18505	COG1162	GTPase activity
NIK71_18510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NIK71_18525	COG1538	Outer membrane efflux protein
NIK71_18530	COG0577	efflux transmembrane transporter activity
NIK71_18530	COG1136	(ABC) transporter
NIK71_18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIK71_18560	COG0028	Belongs to the TPP enzyme family
NIK71_18565	COG0440	acetolactate synthase activity
NIK71_18595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NIK71_18610	COG0084	hydrolase, TatD family'
NIK71_18625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NIK71_18635	COG0583	DNA-binding transcription factor activity
NIK71_18645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIK71_18650	COG2814	Major facilitator Superfamily
NIK71_18660	COG0697	spore germination
NIK71_18690	COG3622	Belongs to the hyi family
NIK71_18695	COG2084	Dehydrogenase
NIK71_18700	COG1024	Enoyl-CoA hydratase
NIK71_18705	COG2205	protein histidine kinase activity
NIK71_18705	COG5002	protein histidine kinase activity
NIK71_18705	COG0784	Response regulator, receiver
NIK71_18725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIK71_18735	COG3956	TIGRFAM MazG family protein
NIK71_18740	COG1555	photosystem II stabilization
NIK71_18745	COG0617	tRNA 3'-terminal CCA addition
NIK71_18750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NIK71_18770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NIK71_18775	COG3028	Belongs to the UPF0307 family
NIK71_18780	COG0318	PFAM AMP-dependent synthetase and ligase
NIK71_18795	COG0625	glutathione transferase activity
NIK71_18800	COG1238	metal cluster binding
NIK71_18845	COG0072	phenylalanine-tRNA ligase activity
NIK71_18875	COG0248	Ppx GppA phosphatase
NIK71_18885	COG0037	tRNA processing
NIK71_18925	COG1764	response to oxidative stress
NIK71_18930	COG1846	Transcriptional regulator
NIK71_18940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIK71_19000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NIK71_19005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NIK71_19010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIK71_19020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIK71_19070	COG1214	PFAM Peptidase M22, glycoprotease
NIK71_19095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NIK71_19100	COG0561	phosphatase activity
NIK71_19110	COG2132	Multicopper oxidase
NIK71_19115	COG3667	copper resistance
NIK71_19130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NIK71_19135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NIK71_19140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NIK71_19170	COG1063	alcohol dehydrogenase
NIK71_19175	COG0583	DNA-binding transcription factor activity
NIK71_19180	COG1960	acyl-CoA dehydrogenase activity
NIK71_19185	COG2814	Major facilitator Superfamily
NIK71_19190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NIK71_19200	COG1053	succinate dehydrogenase
NIK71_19205	COG0583	DNA-binding transcription factor activity
NIK71_19220	COG0583	DNA-binding transcription factor activity
NIK71_19250	COG0583	DNA-binding transcription factor activity
NIK71_19265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIK71_19285	COG1061	Type III restriction enzyme res subunit
NIK71_19295	COG1192	Involved in chromosome partitioning
NIK71_19300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIK71_19310	COG1061	Type III restriction enzyme res subunit
NIK71_19330	COG1061	Type III restriction enzyme res subunit
NIK71_19340	COG1192	Involved in chromosome partitioning
NIK71_19345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIK71_19355	COG1061	Type III restriction enzyme res subunit
NIK71_19490	COG1525	nuclease
NIK71_19555	COG1475	DNA binding
NIK71_19570	COG3853	Toxic anion resistance protein (TelA)
NIK71_19665	COG0484	heat shock protein binding
NIK71_19760	COG0741	lytic transglycosylase activity
NIK71_19795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process