locus-tag	class	description
NH456_00005	COG2165	general secretion pathway protein
NH456_00055	COG0776	regulation of translation
NH456_00085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NH456_00140	COG0339	signal peptide processing
NH456_00150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NH456_00185	COG0702	epimerase
NH456_00190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NH456_00210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NH456_00240	COG0316	Belongs to the HesB IscA family
NH456_00245	COG0822	iron-sulfur transferase activity
NH456_00270	COG0776	regulation of translation
NH456_00280	COG2207	Transcriptional regulator
NH456_00285	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NH456_00290	COG1960	acyl-CoA dehydrogenase activity
NH456_00295	COG1960	acyl-CoA dehydrogenase activity
NH456_00310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NH456_00335	COG4264	IucA IucC family
NH456_00390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NH456_00410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NH456_00415	COG0730	response to heat
NH456_00455	COG0842	Transport permease protein
NH456_00575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NH456_00585	COG0133	tryptophan synthase activity
NH456_00600	COG3706	GGDEF domain
NH456_00615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NH456_00620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NH456_00625	COG0022	dehydrogenase e1 component
NH456_00630	COG0508	dehydrogenase complex catalyzes the overall conversion of
NH456_00650	COG3781	membrane
NH456_00660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NH456_00660	COG3453	Protein conserved in bacteria
NH456_00675	COG0730	response to heat
NH456_00690	COG2207	Transcriptional regulator
NH456_00690	COG3708	Transcriptional regulator
NH456_00695	COG1733	regulation of RNA biosynthetic process
NH456_00700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NH456_00710	COG2188	Transcriptional regulator
NH456_00730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NH456_00760	COG1027	Aspartate ammonia-lyase
NH456_00775	COG0583	DNA-binding transcription factor activity
NH456_00780	COG0583	DNA-binding transcription factor activity
NH456_00785	COG0183	Belongs to the thiolase family
NH456_00790	COG2031	fatty acid transporter
NH456_00795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NH456_00815	COG2610	gluconate transmembrane transporter activity
NH456_00820	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_00830	COG2207	Transcriptional regulator
NH456_00875	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NH456_00880	COG4638	Rieske (2fe-2S)
NH456_00890	COG0725	ABC transporter, periplasmic molybdate-binding protein
NH456_00895	COG4149	molybdate abc transporter
NH456_00900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NH456_00905	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_00910	COG1535	isochorismatase
NH456_00910	COG3433	isochorismatase activity
NH456_00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NH456_00985	COG0753	catalase activity
NH456_00995	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NH456_01025	COG3539	Fimbrial protein
NH456_01045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NH456_01065	COG2072	flavoprotein involved in K transport
NH456_01075	COG1538	Outer membrane efflux protein
NH456_01080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NH456_01090	COG0745	RESPONSE REGULATOR receiver
NH456_01095	COG2205	protein histidine kinase activity
NH456_01105	COG2207	Transcriptional regulator
NH456_01120	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_01170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NH456_01290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NH456_01310	COG1120	ATPase activity
NH456_01315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NH456_01340	COG2207	Transcriptional regulator
NH456_01345	COG2084	Dehydrogenase
NH456_01360	COG0583	DNA-binding transcription factor activity
NH456_01370	COG0129	dihydroxy-acid dehydratase activity
NH456_01375	COG1012	belongs to the aldehyde dehydrogenase family
NH456_01390	COG1566	PFAM secretion protein HlyD family protein
NH456_01425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NH456_01455	COG0583	DNA-binding transcription factor activity
NH456_01470	COG2188	Transcriptional regulator
NH456_01500	COG3210	domain, Protein
NH456_01505	COG2831	hemolysin activation secretion protein
NH456_01515	COG1473	amidohydrolase
NH456_01525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NH456_01525	COG0475	glutathione-regulated potassium exporter activity
NH456_01535	COG0583	DNA-binding transcription factor activity
NH456_01540	COG1335	isochorismatase
NH456_01550	COG1309	transcriptional regulator
NH456_01580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NH456_01590	COG0446	pyridine nucleotide-disulphide oxidoreductase
NH456_01590	COG1902	pentaerythritol trinitrate reductase activity
NH456_01595	COG1846	Transcriptional regulator
NH456_01615	COG0753	catalase activity
NH456_01630	COG1012	belongs to the aldehyde dehydrogenase family
NH456_01645	COG3162	membrane
NH456_01665	COG1960	acyl-CoA dehydrogenase activity
NH456_01685	COG1012	belongs to the aldehyde dehydrogenase family
NH456_01705	COG2186	Transcriptional regulator
NH456_01715	COG0583	DNA-binding transcription factor activity
NH456_01720	COG4948	Mandelate Racemase Muconate Lactonizing
NH456_01725	COG4829	muconolactone delta-isomerase
NH456_01735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NH456_01740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NH456_01745	COG0183	Belongs to the thiolase family
NH456_01770	COG3733	amine oxidase
NH456_01820	COG0154	amidase activity
NH456_01830	COG2814	Major facilitator Superfamily
NH456_01855	COG1960	acyl-CoA dehydrogenase activity
NH456_01865	COG1414	Transcriptional regulator
NH456_01880	COG2391	methyltransferase activity
NH456_01890	COG4993	Dehydrogenase
NH456_01895	COG3659	wide pore channel activity
NH456_01900	COG3420	alginic acid biosynthetic process
NH456_01905	COG0710	3-dehydroquinate dehydratase activity
NH456_01915	COG3485	protocatechuate 3,4-dioxygenase
NH456_01920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NH456_01930	COG0596	Alpha beta hydrolase
NH456_01935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NH456_01940	COG0183	Belongs to the thiolase family
NH456_01945	COG0183	Belongs to the thiolase family
NH456_01950	COG0183	Belongs to the thiolase family
NH456_01955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NH456_01960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NH456_01970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NH456_01975	COG2323	membrane
NH456_02025	COG1902	pentaerythritol trinitrate reductase activity
NH456_02025	COG0446	pyridine nucleotide-disulphide oxidoreductase
NH456_02050	COG0542	response to heat
NH456_02055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NH456_02085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NH456_02090	COG0569	domain protein
NH456_02095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NH456_02115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NH456_02125	COG1585	Membrane protein implicated in regulation of membrane protease activity
NH456_02145	COG4890	Cyd operon protein YbgT
NH456_02160	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NH456_02195	COG0517	IMP dehydrogenase activity
NH456_02195	COG0516	GMP reductase activity
NH456_02200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NH456_02205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NH456_02215	COG0583	DNA-binding transcription factor activity
NH456_02220	COG0024	Methionine aminopeptidase
NH456_02255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NH456_02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH456_02265	COG1105	Belongs to the carbohydrate kinase PfkB family
NH456_02270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH456_02270	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NH456_02270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NH456_02305	COG2135	peptidase activity
NH456_02310	COG0659	secondary active sulfate transmembrane transporter activity
NH456_02330	COG1113	amino acid transport
NH456_02365	COG1011	Hydrolase
NH456_02380	COG2137	regulation of response to DNA damage stimulus
NH456_02395	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NH456_02430	COG0575	Belongs to the CDS family
NH456_02435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NH456_02455	COG3852	Histidine kinase
NH456_02460	COG2204	response regulator
NH456_02515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NH456_02520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NH456_02545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NH456_02555	COG0303	'Molybdopterin
NH456_02560	COG0521	Mo-molybdopterin cofactor biosynthetic process
NH456_02560	COG0315	cyclic pyranopterin monophosphate synthase activity
NH456_02595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NH456_02600	COG2146	nitrite reductase [NAD(P)H] activity
NH456_02600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NH456_02610	COG0745	RESPONSE REGULATOR receiver
NH456_02635	COG0511	ligase activity, forming carbon-carbon bonds
NH456_02690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NH456_02700	COG1454	alcohol dehydrogenase
NH456_02705	COG0824	Thioesterase
NH456_02715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NH456_02745	COG0183	Belongs to the thiolase family
NH456_02755	COG0583	DNA-binding transcription factor activity
NH456_02760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NH456_02770	COG1522	sequence-specific DNA binding
NH456_02775	COG3135	benzoate transporter
NH456_02785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NH456_02810	COG0589	response to stress
NH456_02815	COG0488	(ABC) transporter
NH456_02870	COG0668	transmembrane transport
NH456_02880	COG1309	transcriptional regulator
NH456_02900	COG1605	Chorismate mutase
NH456_02910	COG4221	oxidoreductase activity
NH456_02920	COG0308	aminopeptidase N
NH456_02940	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NH456_02950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NH456_02955	COG1454	alcohol dehydrogenase
NH456_02975	COG0531	amino acid
NH456_02980	COG4303	Ethanolamine ammonia lyase large subunit
NH456_02985	COG4302	ethanolamine ammonia-lyase activity
NH456_02990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NH456_02990	COG0519	Catalyzes the synthesis of GMP from XMP
NH456_02995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NH456_03020	COG0697	spore germination
NH456_03025	COG1923	regulation of RNA biosynthetic process
NH456_03035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NH456_03040	COG0802	atpase or kinase
NH456_03075	COG0583	DNA-binding transcription factor activity
NH456_03090	COG2814	Major facilitator Superfamily
NH456_03095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NH456_03120	COG0729	surface antigen
NH456_03140	COG0174	glutamine synthetase
NH456_03145	COG0745	RESPONSE REGULATOR receiver
NH456_03160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NH456_03165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NH456_03190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NH456_03195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NH456_03200	COG1960	acyl-CoA dehydrogenase activity
NH456_03215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NH456_03220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NH456_03265	COG3658	cytochrome
NH456_03275	COG0726	polysaccharide deacetylase
NH456_03275	COG1649	PFAM Uncharacterised BCR, COG1649
NH456_03300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NH456_03305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NH456_03315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NH456_03340	COG0305	Participates in initiation and elongation during chromosome replication
NH456_03345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NH456_03355	COG1305	Transglutaminase-like
NH456_03365	COG2308	Evidence 4 Homologs of previously reported genes of
NH456_03395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NH456_03400	COG0138	bifunctional purine biosynthesis protein purh
NH456_03405	COG0151	Belongs to the GarS family
NH456_03410	COG1464	Belongs to the NlpA lipoprotein family
NH456_03415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NH456_03425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NH456_03435	COG1301	dicarboxylic acid transport
NH456_03475	COG2433	Pfam Transposase IS66
NH456_03485	COG3173	Aminoglycoside phosphotransferase
NH456_03490	COG0488	(ABC) transporter
NH456_03565	COG0583	DNA-binding transcription factor activity
NH456_03570	COG1279	arginine transmembrane transporter activity
NH456_03590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH456_03595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH456_03600	COG0006	proline dipeptidase activity
NH456_04010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NH456_04050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NH456_04055	COG2878	Part of a membrane complex involved in electron transport
NH456_04085	COG0768	penicillin binding
NH456_04090	COG0742	ribosomal rna small subunit methyltransferase
NH456_04105	COG0830	nickel cation binding
NH456_04115	COG0804	urea catabolic process
NH456_04155	COG1253	flavin adenine dinucleotide binding
NH456_04160	COG2851	Citrate transporter
NH456_04210	COG1773	rubredoxin
NH456_04215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NH456_04225	COG0583	DNA-binding transcription factor activity
NH456_04250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NH456_04255	COG4181	ATPase activity
NH456_04300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NH456_04320	COG0306	phosphate transporter
NH456_04330	COG3958	Transketolase
NH456_04335	COG3959	Transketolase, thiamine diphosphate binding domain
NH456_04340	COG2271	Major facilitator Superfamily
NH456_04345	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_04350	COG0583	DNA-binding transcription factor activity
NH456_04365	COG2223	nitrite transmembrane transporter activity
NH456_04370	COG2207	Transcriptional regulator
NH456_04380	COG0242	peptide deformylase activity
NH456_04385	COG0477	Major facilitator Superfamily
NH456_04410	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_04415	COG2267	carboxylic ester hydrolase activity
NH456_04425	COG2271	Major facilitator Superfamily
NH456_04440	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_04460	COG1414	Transcriptional regulator
NH456_04475	COG1024	Enoyl-CoA hydratase
NH456_04485	COG1215	transferase activity, transferring glycosyl groups
NH456_04490	COG0726	polysaccharide deacetylase
NH456_04490	COG1649	PFAM Uncharacterised BCR, COG1649
NH456_04500	COG4681	YaeQ
NH456_04520	COG1607	acyl-coa hydrolase
NH456_04530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NH456_04535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NH456_04540	COG1309	transcriptional regulator
NH456_04565	COG2040	homocysteine
NH456_04570	COG0531	amino acid
NH456_04600	COG0477	Major facilitator Superfamily
NH456_04735	COG0592	DNA-directed DNA polymerase activity
NH456_04780	COG2026	Addiction module toxin, RelE StbE family
NH456_05015	COG1484	DNA-dependent DNA replication
NH456_05130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NH456_05170	COG2814	Major facilitator Superfamily
NH456_05180	COG2050	protein possibly involved in aromatic compounds catabolism
NH456_05195	COG1090	epimerase
NH456_05215	COG0420	3'-5' exonuclease activity
NH456_05240	COG0735	belongs to the Fur family
NH456_05245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NH456_05265	COG0121	glutamine amidotransferase
NH456_05295	COG2885	chlorophyll binding
NH456_05300	COG0204	Acyl-transferase
NH456_05315	COG2894	cell division
NH456_05335	COG1280	lysine exporter protein (LysE YggA)
NH456_05345	COG0492	ferredoxin-NADP+ reductase activity
NH456_05360	COG0456	acetyltransferase
NH456_05405	COG1981	membrane
NH456_05420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NH456_05420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NH456_05440	COG1012	belongs to the aldehyde dehydrogenase family
NH456_05450	COG0657	acetylesterase activity
NH456_05460	COG0473	3-isopropylmalate dehydrogenase activity
NH456_05485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NH456_05510	COG0564	pseudouridine synthase activity
NH456_05520	COG0358	DNA primase activity
NH456_05535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NH456_05565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NH456_05595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NH456_05605	COG0351	phosphomethylpyrimidine kinase
NH456_05605	COG0352	thiamine-phosphate diphosphorylase activity
NH456_05605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NH456_05610	COG1652	LysM domain
NH456_05635	COG1399	metal-binding, possibly nucleic acid-binding protein
NH456_05640	COG3101	peptidyl-lysine hydroxylation
NH456_05645	COG0009	L-threonylcarbamoyladenylate synthase
NH456_05650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NH456_05655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NH456_05670	COG4106	trans-aconitate 2-methyltransferase activity
NH456_05690	COG1877	trehalose-phosphatase activity
NH456_05695	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NH456_05700	COG2223	nitrite transmembrane transporter activity
NH456_05720	COG1196	nuclear chromosome segregation
NH456_05730	COG0730	response to heat
NH456_05755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NH456_05805	COG0489	protein tyrosine kinase activity
NH456_05815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH456_05815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH456_05845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NH456_05850	COG2081	HI0933 family
NH456_05860	COG0668	transmembrane transport
NH456_05900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NH456_05935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NH456_05975	COG0745	RESPONSE REGULATOR receiver
NH456_05995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NH456_06005	COG2205	protein histidine kinase activity
NH456_06105	COG0384	phenazine biosynthesis protein PhzF
NH456_06130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NH456_06145	COG0583	DNA-binding transcription factor activity
NH456_06175	COG0583	DNA-binding transcription factor activity
NH456_06190	COG0583	DNA-binding transcription factor activity
NH456_06195	COG1053	succinate dehydrogenase
NH456_06205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NH456_06210	COG2814	Major facilitator Superfamily
NH456_06215	COG1960	acyl-CoA dehydrogenase activity
NH456_06220	COG0583	DNA-binding transcription factor activity
NH456_06225	COG1063	alcohol dehydrogenase
NH456_06260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NH456_06285	COG2132	Multicopper oxidase
NH456_06295	COG0561	phosphatase activity
NH456_06300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NH456_06325	COG1214	PFAM Peptidase M22, glycoprotease
NH456_06375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NH456_06385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NH456_06390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NH456_06395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NH456_06455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NH456_06465	COG1846	Transcriptional regulator
NH456_06470	COG1764	response to oxidative stress
NH456_06510	COG0037	tRNA processing
NH456_06520	COG0248	Ppx GppA phosphatase
NH456_06550	COG0072	phenylalanine-tRNA ligase activity
NH456_06595	COG1238	metal cluster binding
NH456_06600	COG0625	glutathione transferase activity
NH456_06615	COG0318	PFAM AMP-dependent synthetase and ligase
NH456_06620	COG3028	Belongs to the UPF0307 family
NH456_06625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NH456_06645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NH456_06655	COG1555	photosystem II stabilization
NH456_06660	COG3956	TIGRFAM MazG family protein
NH456_06670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NH456_06695	COG1024	Enoyl-CoA hydratase
NH456_06705	COG3622	Belongs to the hyi family
NH456_06735	COG0697	spore germination
NH456_06745	COG2814	Major facilitator Superfamily
NH456_06760	COG0583	DNA-binding transcription factor activity
NH456_06770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NH456_06800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NH456_06830	COG0440	acetolactate synthase activity
NH456_06870	COG1538	Outer membrane efflux protein
NH456_06885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NH456_06890	COG1162	GTPase activity
NH456_06900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NH456_06920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NH456_06925	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_06965	COG2986	histidine ammonia-lyase
NH456_06980	COG0318	PFAM AMP-dependent synthetase and ligase
NH456_06990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NH456_07095	COG1012	belongs to the aldehyde dehydrogenase family
NH456_07100	COG3265	gluconokinase activity
NH456_07110	COG0800	Aldolase
NH456_07120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NH456_07125	COG0280	phosphate acetyltransferase
NH456_07125	COG0857	belongs to the CobB CobQ family
NH456_07150	COG0740	serine-type endopeptidase activity
NH456_07180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NH456_07180	COG2813	Specifically methylates the guanine in position
NH456_07280	COG0788	formyltetrahydrofolate deformylase activity
NH456_07305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NH456_07305	COG4651	solute:proton antiporter activity
NH456_07325	COG0724	RNA recognition motif
NH456_07330	COG0210	DNA helicase
NH456_07355	COG1733	regulation of RNA biosynthetic process
NH456_07365	COG2900	Belongs to the SlyX family
NH456_07370	COG0488	(ABC) transporter
NH456_07375	COG1280	lysine exporter protein (LysE YggA)
NH456_07380	COG1560	Kdo2-lipid A biosynthetic process
NH456_07445	COG0473	3-isopropylmalate dehydrogenase activity
NH456_07510	COG0583	DNA-binding transcription factor activity
NH456_07520	COG0625	glutathione transferase activity
NH456_07525	COG2378	regulation of single-species biofilm formation
NH456_07530	COG0546	phosphoglycolate phosphatase activity
NH456_07540	COG1530	ribonuclease E activity
NH456_07545	COG0318	PFAM AMP-dependent synthetase and ligase
NH456_07560	COG0583	DNA-binding transcription factor activity
NH456_07565	COG4221	oxidoreductase activity
NH456_07570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NH456_07580	COG0534	Mate efflux family protein
NH456_07595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NH456_07635	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NH456_07640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NH456_07655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NH456_07670	COG0425	Belongs to the sulfur carrier protein TusA family
NH456_07675	COG4535	Mg2 and Co2 transporter CorC
NH456_07685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NH456_07710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NH456_07720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NH456_07735	COG0789	Transcriptional regulator
NH456_07740	COG0598	Magnesium transport protein CorA
NH456_07755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NH456_07790	COG2226	methyltransferase
NH456_07805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH456_07810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NH456_07830	COG1006	Multisubunit Na H antiporter MnhC subunit
NH456_07840	COG1863	multisubunit Na H antiporter MnhE subunit
NH456_07845	COG2212	antiporter activity
NH456_07850	COG1320	monovalent cation:proton antiporter activity
NH456_07915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NH456_07920	COG0237	dephospho-CoA kinase activity
NH456_07930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NH456_07945	COG0497	DNA recombination
NH456_07990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NH456_08055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NH456_08070	COG0326	Molecular chaperone. Has ATPase activity
NH456_08085	COG2056	Na+-H+ antiporter family
NH456_08090	COG0596	Alpha beta hydrolase
NH456_08185	COG0546	phosphoglycolate phosphatase activity
NH456_08190	COG1716	ATPase activity
NH456_08235	COG0181	hydroxymethylbilane synthase activity
NH456_08245	COG3275	phosphorelay sensor kinase activity
NH456_08265	COG1538	Outer membrane efflux protein
NH456_08270	COG0697	spore germination
NH456_08295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NH456_08300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NH456_08305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NH456_08310	COG0772	Belongs to the SEDS family
NH456_08335	COG4974	Belongs to the 'phage' integrase family
NH456_08340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NH456_08360	COG2197	response regulator
NH456_08375	COG0793	Belongs to the peptidase S41A family
NH456_08385	COG0795	lipopolysaccharide-transporting ATPase activity
NH456_08425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NH456_08425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NH456_08435	COG0004	ammonium transporteR
NH456_08440	COG0347	Belongs to the P(II) protein family
NH456_08505	COG1002	Type II restriction enzyme, methylase subunits
NH456_08510	COG1061	Type III restriction enzyme res subunit
NH456_08530	COG0659	secondary active sulfate transmembrane transporter activity
NH456_08535	COG0589	response to stress
NH456_08575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NH456_08620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NH456_08655	COG1002	Type II restriction enzyme, methylase subunits
NH456_08660	COG1061	Type III restriction enzyme res subunit
NH456_08720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NH456_08750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NH456_08765	COG0318	PFAM AMP-dependent synthetase and ligase
NH456_08775	COG0477	Major facilitator Superfamily
NH456_08780	COG2860	membrane
NH456_08810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NH456_08860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NH456_08930	COG0758	DNA mediated transformation
NH456_08940	COG0697	spore germination
NH456_08945	COG1309	transcriptional regulator
NH456_08960	COG0386	Belongs to the glutathione peroxidase family
NH456_09030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NH456_09035	COG1280	lysine exporter protein (LysE YggA)
NH456_09040	COG2837	iron assimilation
NH456_09050	COG0281	malic enzyme
NH456_09095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NH456_09095	COG0519	Catalyzes the synthesis of GMP from XMP
NH456_09100	COG4399	Belongs to the UPF0754 family
NH456_09105	COG2259	Doxx family
NH456_09110	COG0586	Pfam SNARE associated Golgi protein
NH456_09135	COG0271	Belongs to the BolA IbaG family
NH456_09155	COG2267	carboxylic ester hydrolase activity
NH456_09175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NH456_09175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NH456_09175	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NH456_09175	COG3321	synthase
NH456_09180	COG1960	acyl-CoA dehydrogenase activity
NH456_09190	COG2197	response regulator
NH456_09200	COG3916	Acyl-homoserine-lactone synthase
NH456_09210	COG1024	Enoyl-CoA hydratase
NH456_09215	COG1024	Enoyl-CoA hydratase
NH456_09245	COG1113	amino acid transport
NH456_09250	COG1113	amino acid transport
NH456_09260	COG0251	oxidation-reduction process
NH456_09300	COG0564	pseudouridine synthase activity
NH456_09380	COG1802	Transcriptional regulator
NH456_09390	COG1448	Aminotransferase
NH456_09395	COG0277	FAD linked oxidase domain protein
NH456_09405	COG2186	Transcriptional regulator
NH456_09425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NH456_09445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NH456_09470	COG1215	transferase activity, transferring glycosyl groups
NH456_09480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NH456_09515	COG3023	N-Acetylmuramoyl-L-alanine amidase
NH456_09570	COG0546	phosphoglycolate phosphatase activity
NH456_09600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NH456_09605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NH456_09610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NH456_09615	COG1116	anion transmembrane transporter activity
NH456_09620	COG1309	transcriptional regulator
NH456_09635	COG0196	riboflavin kinase activity
NH456_09640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NH456_09650	COG1047	Peptidyl-prolyl cis-trans
NH456_09690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NH456_09695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NH456_09700	COG0596	Alpha beta hydrolase
NH456_09725	COG0488	(ABC) transporter
NH456_09730	COG0586	Pfam SNARE associated Golgi protein
NH456_09750	COG0592	DNA-directed DNA polymerase activity
NH456_09775	COG0706	membrane insertase activity
NH456_09790	COG1230	cation diffusion facilitator family transporter
NH456_09795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NH456_09810	COG0402	S-adenosylhomocysteine deaminase activity
NH456_09835	COG0671	phosphoesterase, PA-phosphatase related
NH456_09845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NH456_09860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NH456_09865	COG2951	lytic endotransglycosylase activity
NH456_09895	COG0583	DNA-binding transcription factor activity
NH456_09915	COG0657	acetylesterase activity
NH456_09920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NH456_09960	COG0733	neurotransmitter:sodium symporter activity
NH456_09995	COG0583	DNA-binding transcription factor activity
NH456_10000	COG2233	PERMEase
NH456_10015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH456_10055	COG0656	L-ascorbic acid biosynthetic process
NH456_10060	COG0583	DNA-binding transcription factor activity
NH456_10075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NH456_10080	COG1064	alcohol dehydrogenase
NH456_10085	COG2818	Glycosylase
NH456_10115	COG5487	UPF0391 membrane protein
NH456_10120	COG2983	Belongs to the UPF0260 family
NH456_10125	COG2133	pyrroloquinoline quinone binding
NH456_10130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NH456_10135	COG2116	formate transmembrane transporter activity
NH456_10155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NH456_10160	COG1335	isochorismatase
NH456_10165	COG0385	Bile acid
NH456_10170	COG0534	Mate efflux family protein
NH456_10175	COG1683	Conserved Protein
NH456_10195	COG0625	glutathione transferase activity
NH456_10205	COG1113	amino acid transport
NH456_10215	COG0523	cobalamin synthesis protein
NH456_10225	COG2188	Transcriptional regulator
NH456_10255	COG0010	Belongs to the arginase family
NH456_10275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NH456_10285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NH456_10390	COG0534	Mate efflux family protein
NH456_10395	COG0436	Aminotransferase
NH456_10400	COG2733	membrane
NH456_10415	COG2918	glutathione biosynthetic process
NH456_10445	COG3150	esterase
NH456_10455	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_10460	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NH456_10470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH456_10480	COG2233	PERMEase
NH456_10485	COG2351	hydroxyisourate hydrolase activity
NH456_10535	COG1393	Belongs to the ArsC family
NH456_10560	COG0189	ligase activity
NH456_10580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NH456_10590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NH456_10605	COG4942	peptidase
NH456_10645	COG0426	domain, Protein
NH456_10645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NH456_10670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NH456_10690	COG1902	pentaerythritol trinitrate reductase activity
NH456_10695	COG1519	Transferase
NH456_10700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NH456_10705	COG0668	transmembrane transport
NH456_10715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NH456_10720	COG1335	isochorismatase
NH456_10725	COG1522	sequence-specific DNA binding
NH456_10755	COG0784	Response regulator, receiver
NH456_10755	COG2198	Histidine kinase
NH456_10755	COG2205	protein histidine kinase activity
NH456_10760	COG3162	membrane
NH456_10775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NH456_10800	COG1309	transcriptional regulator
NH456_10820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NH456_10820	COG0352	thiamine-phosphate diphosphorylase activity
NH456_10820	COG0351	phosphomethylpyrimidine kinase
NH456_10830	COG2814	Major facilitator Superfamily
NH456_10845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NH456_10865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NH456_10870	COG1012	belongs to the aldehyde dehydrogenase family
NH456_10880	COG1335	isochorismatase
NH456_10915	COG0583	DNA-binding transcription factor activity
NH456_10935	COG0667	Aldo Keto reductase
NH456_10970	COG1733	regulation of RNA biosynthetic process
NH456_11055	COG2329	Antibiotic biosynthesis monooxygenase
NH456_11085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NH456_11115	COG0427	acetyl-CoA hydrolase
NH456_11140	COG0659	secondary active sulfate transmembrane transporter activity
NH456_11145	COG4221	oxidoreductase activity
NH456_11155	COG0488	(ABC) transporter
NH456_11240	COG0833	amino acid
NH456_11285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NH456_11305	COG2226	methyltransferase
NH456_11355	COG0070	glutamate synthase
NH456_11355	COG0067	glutamate synthase
NH456_11355	COG0069	glutamate synthase activity
NH456_11360	COG0493	'glutamate synthase
NH456_11370	COG1704	LemA family
NH456_11430	COG0194	GDP metabolic process
NH456_11480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NH456_11530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NH456_11535	COG0277	FAD linked oxidase domain protein
NH456_11550	COG2249	NAD(P)H dehydrogenase (quinone) activity
NH456_11580	COG1192	Involved in chromosome partitioning
NH456_11610	COG0833	amino acid
NH456_11615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NH456_11635	COG1012	belongs to the aldehyde dehydrogenase family
NH456_11720	COG0517	IMP dehydrogenase activity
NH456_11725	COG1983	PspC domain protein
NH456_11735	COG1960	acyl-CoA dehydrogenase activity
NH456_11770	COG0513	Belongs to the DEAD box helicase family
NH456_11780	COG1127	ABC transporter
NH456_11785	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NH456_11795	COG2854	intermembrane phospholipid transfer
NH456_11805	COG0598	Magnesium transport protein CorA
NH456_11815	COG0494	nUDIX hydrolase
NH456_11820	COG1040	competence protein
NH456_11825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NH456_11850	COG1301	dicarboxylic acid transport
NH456_11865	COG1959	2 iron, 2 sulfur cluster binding
NH456_11870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NH456_11870	COG1017	nitric oxide dioxygenase activity
NH456_11875	COG0433	COG0433 Predicted ATPase
NH456_11880	COG0626	cystathionine gamma-synthase activity
NH456_12035	COG1960	acyl-CoA dehydrogenase activity
NH456_12040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NH456_12070	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NH456_12135	COG0697	spore germination
NH456_12140	COG1295	ribonuclease BN
NH456_12215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NH456_12270	COG1309	transcriptional regulator
NH456_12285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NH456_12290	COG1960	acyl-CoA dehydrogenase activity
NH456_12310	COG2969	positive regulation of protein catabolic process
NH456_12320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NH456_12335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NH456_12375	COG1408	metallophosphoesterase
NH456_12385	COG2199	diguanylate cyclase activity
NH456_12445	COG1607	acyl-coa hydrolase
NH456_12475	COG2350	Protein conserved in bacteria
NH456_12485	COG0613	PHP domain protein
NH456_12490	COG3781	membrane
NH456_12500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NH456_12505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NH456_12515	COG1862	Preprotein translocase
NH456_12570	COG2205	protein histidine kinase activity
NH456_12575	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NH456_12595	COG0726	polysaccharide deacetylase
NH456_12600	COG0463	Glycosyl transferase, family 2
NH456_12670	COG0625	glutathione transferase activity
NH456_12680	COG1960	acyl-CoA dehydrogenase activity
NH456_12685	COG1960	acyl-CoA dehydrogenase activity
NH456_12695	COG2205	protein histidine kinase activity
NH456_12700	COG0745	RESPONSE REGULATOR receiver
NH456_12705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NH456_12725	COG2096	Adenosyltransferase
NH456_12775	COG0285	dihydrofolate synthase activity
NH456_12815	COG1272	protein, Hemolysin III
NH456_12845	COG0183	Belongs to the thiolase family
NH456_12850	COG2207	Transcriptional regulator
NH456_12870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NH456_12890	COG0183	Belongs to the thiolase family
NH456_12910	COG1690	Belongs to the RtcB family
NH456_12915	COG0833	amino acid
NH456_12925	COG2233	PERMEase
NH456_12930	COG1217	gtp-binding protein TYPA
NH456_12955	COG2094	Belongs to the DNA glycosylase MPG family
NH456_12975	COG1902	pentaerythritol trinitrate reductase activity
NH456_12990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NH456_12995	COG0354	folic acid binding
NH456_13005	COG3189	MarR family transcriptional regulator
NH456_13010	COG2824	Alkylphosphonate utilization operon protein PhnA
NH456_13015	COG3422	double-strand break repair
NH456_13055	COG0840	transmembrane signaling receptor activity
NH456_13075	COG5510	response to toxic substance
NH456_13085	COG2832	Protein of unknown function (DUF454)
NH456_13090	COG1376	ErfK ybiS ycfS ynhG family protein
NH456_13130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NH456_13140	COG1289	transmembrane transporter activity
NH456_13175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NH456_13180	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NH456_13210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NH456_13220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NH456_13225	COG1077	Cell shape determining protein MreB Mrl
NH456_13230	COG1792	Involved in formation and maintenance of cell shape
NH456_13235	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NH456_13240	COG0424	maF-like protein
NH456_13245	COG1530	ribonuclease E activity
NH456_13255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NH456_13265	COG0560	Phosphoserine phosphatase
NH456_13320	COG1113	amino acid transport
NH456_13325	COG2828	Protein conserved in bacteria
NH456_13330	COG0142	geranyltranstransferase activity
NH456_13335	COG2315	Protein conserved in bacteria
NH456_13350	COG1752	Esterase of the alpha-beta hydrolase superfamily
NH456_13370	COG2194	sulfuric ester hydrolase activity
NH456_13390	COG0004	ammonium transporteR
NH456_13395	COG0583	DNA-binding transcription factor activity
NH456_13425	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_13440	COG0393	Putative heavy-metal-binding
NH456_13445	COG1538	Outer membrane efflux protein
NH456_13455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH456_13460	COG0671	phosphoesterase, PA-phosphatase related
NH456_13505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NH456_13505	COG1648	precorrin-2 dehydrogenase activity
NH456_13510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NH456_13515	COG1733	regulation of RNA biosynthetic process
NH456_13525	COG0531	amino acid
NH456_13545	COG2921	Belongs to the UPF0250 family
NH456_13585	COG2009	succinate dehydrogenase
NH456_13590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NH456_13595	COG1053	succinate dehydrogenase
NH456_13600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NH456_13625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NH456_13645	COG2354	Protein conserved in bacteria
NH456_13650	COG2321	neutral zinc metallopeptidase
NH456_13670	COG2843	Capsule synthesis protein
NH456_13685	COG0589	response to stress
NH456_13705	COG0505	Belongs to the CarA family
NH456_13730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NH456_13735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NH456_13785	COG0477	Major facilitator Superfamily
NH456_13805	COG1597	lipid kinase activity
NH456_13810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NH456_13835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NH456_13840	COG0584	glycerophosphoryl diester phosphodiesterase
NH456_13860	COG0741	lytic transglycosylase activity
NH456_13880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NH456_13925	COG0778	Nitroreductase
NH456_13940	COG1929	Belongs to the glycerate kinase type-1 family
NH456_13945	COG0243	molybdopterin cofactor binding
NH456_13950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NH456_13965	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NH456_13980	COG1113	amino acid transport
NH456_13990	COG0019	diaminopimelate decarboxylase activity
NH456_14000	COG1280	lysine exporter protein (LysE YggA)
NH456_14005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NH456_14035	COG0463	Glycosyl transferase, family 2
NH456_14055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH456_14090	COG4591	ABC-type transport system involved in lipoprotein release permease component
NH456_14095	COG1136	(ABC) transporter
NH456_14100	COG2333	competence protein COMEC
NH456_14100	COG0658	competence protein
NH456_14110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NH456_14110	COG0616	signal peptide processing
NH456_14115	COG0596	Alpha beta hydrolase
NH456_14120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NH456_14130	COG0628	permease
NH456_14165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NH456_14215	COG0824	Thioesterase
NH456_14220	COG1473	amidohydrolase
NH456_14245	COG2814	Major facilitator Superfamily
NH456_14265	COG1051	belongs to the nudix hydrolase family
NH456_14265	COG1056	cytidyltransferase-related domain
NH456_14275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NH456_14290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NH456_14305	COG4625	pathogenesis
NH456_14310	COG0583	DNA-binding transcription factor activity
NH456_14315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NH456_14320	COG4208	sulfate ABC transporter
NH456_14325	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NH456_14335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NH456_14340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NH456_14345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NH456_14365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NH456_14380	COG0681	Belongs to the peptidase S26 family
NH456_14405	COG1381	Involved in DNA repair and RecF pathway recombination
NH456_14410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NH456_14420	COG4221	oxidoreductase activity
NH456_14450	COG0436	Aminotransferase
NH456_14525	COG2070	2-Nitropropane dioxygenase
NH456_14555	COG1215	transferase activity, transferring glycosyl groups
NH456_14625	COG0477	Major facilitator Superfamily
NH456_14630	COG0583	DNA-binding transcription factor activity
NH456_14645	COG0612	Peptidase, M16
NH456_14670	COG0352	thiamine-phosphate diphosphorylase activity
NH456_14705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NH456_14720	COG1309	transcriptional regulator
NH456_14730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NH456_14735	COG0076	glutamate decarboxylase activity
NH456_14745	COG1522	sequence-specific DNA binding
NH456_14755	COG1113	amino acid transport
NH456_14760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NH456_14765	COG0573	inorganic phosphate transmembrane transporter activity
NH456_14775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NH456_14810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NH456_14815	COG1686	Belongs to the peptidase S11 family
NH456_14840	COG0583	DNA-binding transcription factor activity
NH456_14845	COG1067	ATP-dependent peptidase activity
NH456_14890	COG1966	Carbon starvation protein
NH456_14895	COG2879	small protein
NH456_14950	COG1113	amino acid transport
NH456_14955	COG0583	DNA-binding transcription factor activity
NH456_14960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NH456_14965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NH456_14975	COG1012	belongs to the aldehyde dehydrogenase family
NH456_14985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NH456_14990	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NH456_14990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NH456_15025	COG2814	Major facilitator Superfamily
NH456_15030	COG4948	Mandelate Racemase Muconate Lactonizing
NH456_15040	COG1309	transcriptional regulator
NH456_15060	COG1741	Belongs to the pirin family
NH456_15070	COG2964	Protein conserved in bacteria
NH456_15085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NH456_15090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NH456_15100	COG4604	ABC transporter, ATP-binding protein
NH456_15105	COG4607	ABC-type enterochelin transport system periplasmic component
NH456_15110	COG4774	siderophore transport
NH456_15125	COG1021	2,3-dihydroxybenzoate-AMP ligase
NH456_15130	COG1535	isochorismatase
NH456_15130	COG3433	isochorismatase activity
NH456_15145	COG1132	(ABC) transporter
NH456_15155	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NH456_15165	COG1169	isochorismate synthase
NH456_15180	COG3739	integral membrane protein
NH456_15205	COG0302	gtp cyclohydrolase
NH456_15245	COG0308	aminopeptidase N
NH456_15250	COG0512	Glutamine amidotransferase of anthranilate synthase
NH456_15275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NH456_15310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NH456_15315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NH456_15320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NH456_15345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NH456_15350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NH456_15365	COG1960	acyl-CoA dehydrogenase activity
NH456_15370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NH456_15375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NH456_15395	COG0024	Methionine aminopeptidase
NH456_15400	COG0052	Belongs to the universal ribosomal protein uS2 family
NH456_15415	COG2207	Transcriptional regulator
NH456_15440	COG2951	lytic endotransglycosylase activity
NH456_15445	COG0772	Belongs to the SEDS family
NH456_15460	COG0842	Transport permease protein
NH456_15465	COG1131	(ABC) transporter
NH456_15510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NH456_15525	COG4215	(ABC) transporter
NH456_15530	COG4160	amino acid transport
NH456_15535	COG4598	ABC transporter
NH456_15545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NH456_15550	COG0826	peptidase U32
NH456_15555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NH456_15570	COG1720	tRNA m6t6A37 methyltransferase activity
NH456_15580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NH456_15595	COG0642	Histidine kinase
NH456_15605	COG0494	nUDIX hydrolase
NH456_15620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NH456_15625	COG3139	Protein of unknown function (DUF1315)
NH456_15630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NH456_15635	COG1301	dicarboxylic acid transport
NH456_15640	COG1960	acyl-CoA dehydrogenase activity
NH456_15645	COG2819	hydrolase of the alpha beta superfamily
NH456_15655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NH456_15665	COG2195	Cleaves the N-terminal amino acid of tripeptides
NH456_15670	COG1234	tRNA 3'-trailer cleavage
NH456_15700	COG2363	Small membrane protein
NH456_15725	COG0513	Belongs to the DEAD box helicase family
NH456_15735	COG0778	Nitroreductase
NH456_15765	COG1286	toxin biosynthetic process
NH456_15790	COG4783	chaperone-mediated protein folding
NH456_15795	COG1610	YqeY-like protein
NH456_15915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NH456_15920	COG0741	lytic transglycosylase activity
NH456_15920	COG0741	lytic transglycosylase activity
NH456_15920	COG1388	LysM domain
NH456_15920	COG1388	LysM domain
NH456_15930	COG4174	ABC transporter (Permease)
NH456_15935	COG4239	(ABC) transporter, permease
NH456_15940	COG4172	Belongs to the ABC transporter superfamily
NH456_15960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NH456_15970	COG4251	negative regulation of phosphorylation
NH456_15970	COG5001	Diguanylate cyclase
NH456_15970	COG2203	Gaf domain
NH456_15970	COG3706	GGDEF domain
NH456_15980	COG0446	pyridine nucleotide-disulphide oxidoreductase
NH456_15980	COG1902	pentaerythritol trinitrate reductase activity
NH456_16145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NH456_16165	COG0300	oxidoreductase activity
NH456_16175	COG1309	transcriptional regulator
NH456_16180	COG1741	Belongs to the pirin family
NH456_16210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NH456_16215	COG3038	cytochrome b561
NH456_16225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NH456_16235	COG0527	aspartate kinase activity
NH456_16245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NH456_16255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NH456_16270	COG0667	Aldo Keto reductase
NH456_16290	COG1765	OsmC-like protein
NH456_16310	COG0542	response to heat
NH456_16345	COG2885	chlorophyll binding
NH456_16355	COG0625	glutathione transferase activity
NH456_16360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NH456_16380	COG3634	alkyl hydroperoxide reductase activity
NH456_16390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NH456_16400	COG0450	alkyl hydroperoxide reductase
NH456_16405	COG1643	Atp-dependent helicase
NH456_16420	COG2814	Major facilitator Superfamily
NH456_16425	COG3135	benzoate transporter
NH456_16430	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_16435	COG0543	2 iron, 2 sulfur cluster binding
NH456_16435	COG0633	Ferredoxin
NH456_16440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NH456_16445	COG4638	Rieske (2fe-2S)
NH456_16505	COG1570	exodeoxyribonuclease VII activity
NH456_16540	COG1278	Cold shock
NH456_16575	COG2814	Major facilitator Superfamily
NH456_16610	COG0517	IMP dehydrogenase activity
NH456_16610	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NH456_16615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NH456_16625	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NH456_16630	COG1137	ATPase activity
NH456_16635	COG1538	Outer membrane efflux protein
NH456_16665	COG4122	O-methyltransferase activity
NH456_16675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NH456_16690	COG1522	sequence-specific DNA binding
NH456_16695	COG5006	permease, DMT superfamily
NH456_16720	COG2814	Major facilitator Superfamily
NH456_16740	COG1250	3-hydroxyacyl-CoA dehydrogenase
NH456_16790	COG0583	DNA-binding transcription factor activity
NH456_16795	COG1914	H( )-stimulated, divalent metal cation uptake system
NH456_16815	COG4770	biotin carboxylase activity
NH456_16825	COG0038	chloride channel
NH456_16855	COG1063	alcohol dehydrogenase
NH456_16870	COG0439	Biotin carboxylase
NH456_16875	COG2249	NAD(P)H dehydrogenase (quinone) activity
NH456_16895	COG0864	Transcriptional regulator
NH456_16905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH456_16910	COG1116	anion transmembrane transporter activity
NH456_17030	COG0590	tRNA wobble adenosine to inosine editing
NH456_17035	COG2807	transmembrane transport
NH456_17040	COG2807	transmembrane transport
NH456_17055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NH456_17070	COG0789	Transcriptional regulator
NH456_17080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NH456_17100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NH456_17125	COG1012	belongs to the aldehyde dehydrogenase family
NH456_17130	COG0531	amino acid
NH456_17140	COG1012	belongs to the aldehyde dehydrogenase family
NH456_17140	COG2030	dehydratase
NH456_17145	COG3396	Phenylacetate-CoA oxygenase
NH456_17150	COG3460	Phenylacetate-CoA oxygenase
NH456_17155	COG3396	Phenylacetate-CoA oxygenase
NH456_17160	COG2151	metal-sulfur cluster biosynthetic enzyme
NH456_17165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NH456_17170	COG1024	Enoyl-CoA hydratase
NH456_17175	COG1024	Enoyl-CoA hydratase
NH456_17180	COG1250	3-hydroxyacyl-CoA dehydrogenase
NH456_17190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NH456_17195	COG3327	negative regulation of DNA-templated transcription, initiation
NH456_17205	COG2050	protein possibly involved in aromatic compounds catabolism
NH456_17245	COG3038	cytochrome b561
NH456_17265	COG2267	carboxylic ester hydrolase activity
NH456_17270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NH456_17275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NH456_17280	COG1012	belongs to the aldehyde dehydrogenase family
NH456_17290	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NH456_17300	COG1012	belongs to the aldehyde dehydrogenase family
NH456_17305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NH456_17310	COG0583	DNA-binding transcription factor activity
NH456_17325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NH456_17335	COG1840	ABC-type Fe3 transport system, periplasmic component
NH456_17355	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NH456_17360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NH456_17365	COG2814	Major facilitator Superfamily
NH456_17370	COG1960	acyl-CoA dehydrogenase activity
NH456_17385	COG1024	Enoyl-CoA hydratase
NH456_17395	COG2814	Major facilitator Superfamily
NH456_17410	COG1250	3-hydroxyacyl-CoA dehydrogenase
NH456_17415	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_17420	COG1024	Enoyl-CoA hydratase
NH456_17425	COG1960	acyl-CoA dehydrogenase activity
NH456_17430	COG2814	Major facilitator Superfamily
NH456_17435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NH456_17440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NH456_17450	COG2814	Major facilitator Superfamily
NH456_17460	COG1960	acyl-CoA dehydrogenase activity
NH456_17485	COG4770	biotin carboxylase activity
NH456_17490	COG1024	Enoyl-CoA hydratase
NH456_17500	COG1960	acyl-CoA dehydrogenase activity
NH456_17505	COG1309	transcriptional regulator
NH456_17530	COG0583	DNA-binding transcription factor activity
NH456_17580	COG1028	Short-chain dehydrogenase reductase Sdr
NH456_17600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NH456_17640	COG0765	amino acid transport
NH456_17650	COG1126	abc transporter atp-binding protein
NH456_17655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH456_17660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NH456_17690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NH456_17695	COG1045	serine acetyltransferase
NH456_17710	COG0583	DNA-binding transcription factor activity
NH456_17715	COG0625	glutathione transferase activity
NH456_17720	COG0625	glutathione transferase activity
NH456_17725	COG0583	DNA-binding transcription factor activity
NH456_17735	COG1346	cytolysis
NH456_17755	COG2814	Major facilitator Superfamily
NH456_17765	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NH456_17770	COG3052	prosthetic group binding
NH456_17790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NH456_17825	COG1271	oxidase subunit
NH456_17845	COG0477	Major facilitator Superfamily
NH456_17860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NH456_17865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NH456_17870	COG2175	clavaminate synthase activity
NH456_17880	COG1953	Uracil, thiamine, allantoin
NH456_17890	COG0583	DNA-binding transcription factor activity
NH456_17915	COG0640	Transcriptional regulator
NH456_17920	COG0798	PFAM Bile acid sodium symporter
NH456_17980	COG0436	Aminotransferase
NH456_17990	COG0386	Belongs to the glutathione peroxidase family
NH456_18030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NH456_18060	COG2011	ABC-type metal ion transport system permease component
NH456_18065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NH456_18075	COG1464	Belongs to the NlpA lipoprotein family
NH456_18105	COG0765	amino acid transport
NH456_18115	COG1126	abc transporter atp-binding protein
NH456_18125	COG1522	sequence-specific DNA binding
NH456_18140	COG1309	transcriptional regulator
NH456_18160	COG0583	DNA-binding transcription factor activity
NH456_18170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NH456_18180	COG0697	spore germination
NH456_18210	COG3539	Fimbrial protein
NH456_18235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NH456_18235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NH456_18280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NH456_18300	COG3698	Phosphodiester glycosidase
NH456_18320	COG0506	proline dehydrogenase activity
NH456_18320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NH456_18320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NH456_18330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NH456_18335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NH456_18355	COG1132	(ABC) transporter
NH456_18360	COG3122	Protein conserved in bacteria
NH456_18375	COG0640	Transcriptional regulator
NH456_18385	COG2850	peptidyl-arginine hydroxylation
NH456_18430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NH456_18450	COG0811	peptide transport
NH456_18465	COG1663	tetraacyldisaccharide 4'-kinase activity
NH456_18485	COG0084	hydrolase, TatD family'