locus-tag	class	description
C4X49_00010	COG0592	DNA-directed DNA polymerase activity
C4X49_00020	COG0187	DNA topoisomerase II activity
C4X49_00030	COG0586	Pfam SNARE associated Golgi protein
C4X49_00035	COG0488	(ABC) transporter
C4X49_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C4X49_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C4X49_00110	COG1047	Peptidyl-prolyl cis-trans
C4X49_00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4X49_00125	COG0196	riboflavin kinase activity
C4X49_00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C4X49_00140	COG1309	transcriptional regulator
C4X49_00145	COG1116	anion transmembrane transporter activity
C4X49_00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4X49_00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4X49_00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4X49_00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4X49_00185	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_00190	COG0546	phosphoglycolate phosphatase activity
C4X49_00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4X49_00255	COG0728	peptidoglycan biosynthetic process
C4X49_00285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C4X49_00320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4X49_00330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4X49_00355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4X49_00370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4X49_00375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4X49_00385	COG2186	Transcriptional regulator
C4X49_00395	COG0277	FAD linked oxidase domain protein
C4X49_00400	COG1448	Aminotransferase
C4X49_00410	COG1802	Transcriptional regulator
C4X49_00425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C4X49_00480	COG0564	pseudouridine synthase activity
C4X49_00505	COG1522	sequence-specific DNA binding
C4X49_00520	COG0251	oxidation-reduction process
C4X49_00525	COG1113	amino acid transport
C4X49_00530	COG1113	amino acid transport
C4X49_00545	COG1401	restriction endodeoxyribonuclease activity
C4X49_00580	COG3293	Transposase
C4X49_00600	COG4115	mRNA cleavage
C4X49_00610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4X49_00715	COG3756	Protein conserved in bacteria
C4X49_00750	COG0271	Belongs to the BolA IbaG family
C4X49_00760	COG1192	Involved in chromosome partitioning
C4X49_00775	COG0586	Pfam SNARE associated Golgi protein
C4X49_00780	COG2259	Doxx family
C4X49_00785	COG4399	Belongs to the UPF0754 family
C4X49_00790	COG0519	Catalyzes the synthesis of GMP from XMP
C4X49_00790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4X49_00835	COG0281	malic enzyme
C4X49_00840	COG2837	iron assimilation
C4X49_00845	COG1280	lysine exporter protein (LysE YggA)
C4X49_00850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C4X49_00855	COG1121	(ABC) transporter
C4X49_00920	COG0386	Belongs to the glutathione peroxidase family
C4X49_00935	COG1309	transcriptional regulator
C4X49_00940	COG0697	spore germination
C4X49_00950	COG0758	DNA mediated transformation
C4X49_00985	COG1309	transcriptional regulator
C4X49_01020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C4X49_01030	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4X49_01065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4X49_01075	COG2814	Major facilitator Superfamily
C4X49_01085	COG1253	flavin adenine dinucleotide binding
C4X49_01095	COG2860	membrane
C4X49_01100	COG0477	Major facilitator Superfamily
C4X49_01110	COG0318	PFAM AMP-dependent synthetase and ligase
C4X49_01125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4X49_01145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4X49_01150	COG0235	Class ii aldolase
C4X49_01155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4X49_01160	COG0606	chelatase, subunit chli
C4X49_01170	COG0347	Belongs to the P(II) protein family
C4X49_01175	COG0004	ammonium transporteR
C4X49_01185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4X49_01185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4X49_01225	COG0795	lipopolysaccharide-transporting ATPase activity
C4X49_01230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4X49_01235	COG0793	Belongs to the peptidase S41A family
C4X49_01250	COG2197	response regulator
C4X49_01260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4X49_01270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4X49_01275	COG4974	Belongs to the 'phage' integrase family
C4X49_01300	COG0772	Belongs to the SEDS family
C4X49_01305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4X49_01310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4X49_01315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4X49_01340	COG0697	spore germination
C4X49_01345	COG1538	Outer membrane efflux protein
C4X49_01365	COG3275	phosphorelay sensor kinase activity
C4X49_01375	COG0181	hydroxymethylbilane synthase activity
C4X49_01420	COG1716	ATPase activity
C4X49_01425	COG0546	phosphoglycolate phosphatase activity
C4X49_01520	COG0596	Alpha beta hydrolase
C4X49_01525	COG2056	Na+-H+ antiporter family
C4X49_01540	COG0326	Molecular chaperone. Has ATPase activity
C4X49_01555	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C4X49_01620	COG3328	transposase activity
C4X49_01630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4X49_01635	COG2169	Transcriptional regulator
C4X49_01635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4X49_01665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4X49_01675	COG0497	DNA recombination
C4X49_01690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4X49_01700	COG0237	dephospho-CoA kinase activity
C4X49_01750	COG0195	Participates in both transcription termination and antitermination
C4X49_01770	COG2212	antiporter activity
C4X49_01780	COG0651	ATP synthesis coupled electron transport
C4X49_01785	COG1006	Multisubunit Na H antiporter MnhC subunit
C4X49_01790	COG2111	Na H antiporter
C4X49_01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4X49_01805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C4X49_01810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4X49_01825	COG2226	methyltransferase
C4X49_01845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C4X49_01850	COG1074	ATP-dependent DNA helicase activity
C4X49_01855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4X49_01875	COG0598	Magnesium transport protein CorA
C4X49_01880	COG0789	Transcriptional regulator
C4X49_01885	COG0484	heat shock protein binding
C4X49_01900	COG0475	glutathione-regulated potassium exporter activity
C4X49_01900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4X49_01905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4X49_01925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4X49_01935	COG4535	Mg2 and Co2 transporter CorC
C4X49_01940	COG0425	Belongs to the sulfur carrier protein TusA family
C4X49_01945	COG0644	oxidoreductase
C4X49_01945	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C4X49_01955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4X49_01970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4X49_01975	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C4X49_02015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4X49_02030	COG0534	Mate efflux family protein
C4X49_02040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4X49_02070	COG1530	ribonuclease E activity
C4X49_02085	COG0546	phosphoglycolate phosphatase activity
C4X49_02090	COG2378	regulation of single-species biofilm formation
C4X49_02095	COG0625	glutathione transferase activity
C4X49_02105	COG0583	DNA-binding transcription factor activity
C4X49_02165	COG0473	3-isopropylmalate dehydrogenase activity
C4X49_02220	COG1301	dicarboxylic acid transport
C4X49_02230	COG1560	Kdo2-lipid A biosynthetic process
C4X49_02235	COG1280	lysine exporter protein (LysE YggA)
C4X49_02255	COG1733	regulation of RNA biosynthetic process
C4X49_02280	COG0210	DNA helicase
C4X49_02285	COG0724	RNA recognition motif
C4X49_02305	COG4651	solute:proton antiporter activity
C4X49_02305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4X49_02310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4X49_02315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4X49_02330	COG0788	formyltetrahydrofolate deformylase activity
C4X49_02430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4X49_02430	COG2813	Specifically methylates the guanine in position
C4X49_02440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4X49_02450	COG4774	siderophore transport
C4X49_02460	COG0740	serine-type endopeptidase activity
C4X49_02480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4X49_02480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C4X49_02485	COG0280	phosphate acetyltransferase
C4X49_02485	COG0857	belongs to the CobB CobQ family
C4X49_02490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C4X49_02500	COG0800	Aldolase
C4X49_02510	COG3265	gluconokinase activity
C4X49_02515	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_02525	COG2267	carboxylic ester hydrolase activity
C4X49_02540	COG0793	Belongs to the peptidase S41A family
C4X49_02575	COG1426	Protein conserved in bacteria
C4X49_02615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4X49_02625	COG1162	GTPase activity
C4X49_02630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4X49_02645	COG1538	Outer membrane efflux protein
C4X49_02650	COG1136	(ABC) transporter
C4X49_02650	COG0577	efflux transmembrane transporter activity
C4X49_02655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4X49_02680	COG0028	Belongs to the TPP enzyme family
C4X49_02685	COG0440	acetolactate synthase activity
C4X49_02805	COG4221	oxidoreductase activity
C4X49_02810	COG0583	DNA-binding transcription factor activity
C4X49_02815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4X49_02820	COG0604	alcohol dehydrogenase
C4X49_02820	COG3321	synthase
C4X49_02835	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4X49_02850	COG1979	alcohol dehydrogenase
C4X49_02860	COG1902	pentaerythritol trinitrate reductase activity
C4X49_02870	COG1309	transcriptional regulator
C4X49_02875	COG2130	NADP-dependent
C4X49_02900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4X49_02915	COG0084	hydrolase, TatD family'
C4X49_02925	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C4X49_02935	COG0583	DNA-binding transcription factor activity
C4X49_02945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4X49_02975	COG3328	transposase activity
C4X49_03010	COG0640	Transcriptional regulator
C4X49_03020	COG0798	PFAM Bile acid sodium symporter
C4X49_03025	COG0431	NADPH-dependent FMN reductase
C4X49_03030	COG0492	ferredoxin-NADP+ reductase activity
C4X49_03035	COG2072	flavoprotein involved in K transport
C4X49_03040	COG3328	transposase activity
C4X49_03050	COG2814	Major facilitator Superfamily
C4X49_03060	COG0697	spore germination
C4X49_03065	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4X49_03070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C4X49_03075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C4X49_03090	COG3622	Belongs to the hyi family
C4X49_03095	COG2084	Dehydrogenase
C4X49_03100	COG1024	Enoyl-CoA hydratase
C4X49_03105	COG0784	Response regulator, receiver
C4X49_03105	COG2205	protein histidine kinase activity
C4X49_03105	COG5002	protein histidine kinase activity
C4X49_03125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4X49_03135	COG3956	TIGRFAM MazG family protein
C4X49_03140	COG1555	photosystem II stabilization
C4X49_03145	COG0617	tRNA 3'-terminal CCA addition
C4X49_03150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4X49_03170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4X49_03175	COG3028	Belongs to the UPF0307 family
C4X49_03180	COG0318	PFAM AMP-dependent synthetase and ligase
C4X49_03195	COG0625	glutathione transferase activity
C4X49_03200	COG1238	metal cluster binding
C4X49_03215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4X49_03240	COG0072	phenylalanine-tRNA ligase activity
C4X49_03270	COG0248	Ppx GppA phosphatase
C4X49_03280	COG0037	tRNA processing
C4X49_03320	COG1764	response to oxidative stress
C4X49_03325	COG1846	Transcriptional regulator
C4X49_03335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4X49_03395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4X49_03400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4X49_03405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4X49_03440	COG1214	PFAM Peptidase M22, glycoprotease
C4X49_03455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4X49_03465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C4X49_03470	COG0561	phosphatase activity
C4X49_03480	COG2132	Multicopper oxidase
C4X49_03500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4X49_03505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4X49_03510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4X49_03540	COG1063	alcohol dehydrogenase
C4X49_03545	COG0583	DNA-binding transcription factor activity
C4X49_03550	COG1960	acyl-CoA dehydrogenase activity
C4X49_03555	COG2814	Major facilitator Superfamily
C4X49_03560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C4X49_03570	COG1053	succinate dehydrogenase
C4X49_03575	COG0583	DNA-binding transcription factor activity
C4X49_03595	COG0583	DNA-binding transcription factor activity
C4X49_03605	COG1473	amidohydrolase
C4X49_03625	COG0583	DNA-binding transcription factor activity
C4X49_03635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4X49_03640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_03665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4X49_03685	COG0745	RESPONSE REGULATOR receiver
C4X49_03690	COG2205	protein histidine kinase activity
C4X49_03725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C4X49_03755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4X49_03760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4X49_03780	COG0583	DNA-binding transcription factor activity
C4X49_03800	COG0668	transmembrane transport
C4X49_03810	COG2081	HI0933 family
C4X49_03815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4X49_03845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4X49_03845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4X49_03855	COG0489	protein tyrosine kinase activity
C4X49_03905	COG3328	transposase activity
C4X49_03920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C4X49_03930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4X49_03945	COG0730	response to heat
C4X49_03955	COG1196	nuclear chromosome segregation
C4X49_03975	COG2223	nitrite transmembrane transporter activity
C4X49_03980	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C4X49_03985	COG1877	trehalose-phosphatase activity
C4X49_03990	COG0596	Alpha beta hydrolase
C4X49_03990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4X49_03990	COG2226	methyltransferase
C4X49_04005	COG4106	trans-aconitate 2-methyltransferase activity
C4X49_04035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C4X49_04040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4X49_04045	COG0009	L-threonylcarbamoyladenylate synthase
C4X49_04050	COG3101	peptidyl-lysine hydroxylation
C4X49_04055	COG1399	metal-binding, possibly nucleic acid-binding protein
C4X49_04080	COG1652	LysM domain
C4X49_04085	COG0351	phosphomethylpyrimidine kinase
C4X49_04085	COG0352	thiamine-phosphate diphosphorylase activity
C4X49_04085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C4X49_04095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C4X49_04125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4X49_04155	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4X49_04170	COG0358	DNA primase activity
C4X49_04180	COG0564	pseudouridine synthase activity
C4X49_04335	COG3328	transposase activity
C4X49_04370	COG0582	viral genome integration into host DNA
C4X49_04380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4X49_04400	COG0583	DNA-binding transcription factor activity
C4X49_04405	COG0473	3-isopropylmalate dehydrogenase activity
C4X49_04425	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_04445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4X49_04445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4X49_04505	COG0456	acetyltransferase
C4X49_04515	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4X49_04520	COG0492	ferredoxin-NADP+ reductase activity
C4X49_04525	COG1674	ftsk spoiiie
C4X49_04525	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C4X49_04530	COG1280	lysine exporter protein (LysE YggA)
C4X49_04545	COG2894	cell division
C4X49_04560	COG0204	Acyl-transferase
C4X49_04565	COG2885	chlorophyll binding
C4X49_04570	COG0210	DNA helicase
C4X49_04580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4X49_04595	COG0121	glutamine amidotransferase
C4X49_04620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4X49_04625	COG0735	belongs to the Fur family
C4X49_04650	COG0420	3'-5' exonuclease activity
C4X49_04670	COG1090	epimerase
C4X49_04685	COG2050	protein possibly involved in aromatic compounds catabolism
C4X49_04695	COG2814	Major facilitator Superfamily
C4X49_04700	COG0405	Gamma-glutamyltransferase
C4X49_04865	COG2801	Transposase and inactivated derivatives
C4X49_04890	COG3328	transposase activity
C4X49_04935	COG0629	single-stranded DNA binding
C4X49_04965	COG0477	Major facilitator Superfamily
C4X49_04970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4X49_04995	COG0531	amino acid
C4X49_05000	COG2040	homocysteine
C4X49_05025	COG1309	transcriptional regulator
C4X49_05030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4X49_05035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4X49_05045	COG1607	acyl-coa hydrolase
C4X49_05055	COG0523	cobalamin synthesis protein
C4X49_05065	COG4681	YaeQ
C4X49_05075	COG1649	PFAM Uncharacterised BCR, COG1649
C4X49_05075	COG0726	polysaccharide deacetylase
C4X49_05080	COG1215	transferase activity, transferring glycosyl groups
C4X49_05090	COG1024	Enoyl-CoA hydratase
C4X49_05105	COG1414	Transcriptional regulator
C4X49_05125	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_05135	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4X49_05140	COG2271	Major facilitator Superfamily
C4X49_05150	COG2267	carboxylic ester hydrolase activity
C4X49_05155	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_05170	COG0028	Belongs to the TPP enzyme family
C4X49_05180	COG0477	Major facilitator Superfamily
C4X49_05185	COG0242	peptide deformylase activity
C4X49_05190	COG2066	Belongs to the glutaminase family
C4X49_05195	COG2207	Transcriptional regulator
C4X49_05200	COG2223	nitrite transmembrane transporter activity
C4X49_05220	COG0583	DNA-binding transcription factor activity
C4X49_05225	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_05230	COG2271	Major facilitator Superfamily
C4X49_05235	COG3959	Transketolase, thiamine diphosphate binding domain
C4X49_05240	COG3958	Transketolase
C4X49_05250	COG0306	phosphate transporter
C4X49_05270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4X49_05315	COG4181	ATPase activity
C4X49_05320	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C4X49_05350	COG0583	DNA-binding transcription factor activity
C4X49_05360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4X49_05365	COG1773	rubredoxin
C4X49_05415	COG2851	Citrate transporter
C4X49_05425	COG1253	flavin adenine dinucleotide binding
C4X49_05470	COG0804	urea catabolic process
C4X49_05480	COG0830	nickel cation binding
C4X49_05495	COG0742	ribosomal rna small subunit methyltransferase
C4X49_05500	COG0768	penicillin binding
C4X49_05525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4X49_05530	COG2878	Part of a membrane complex involved in electron transport
C4X49_05535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4X49_05545	COG3384	dioxygenase
C4X49_05565	COG3328	transposase activity
C4X49_05580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4X49_05620	COG0006	proline dipeptidase activity
C4X49_05625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4X49_05630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4X49_05650	COG1279	arginine transmembrane transporter activity
C4X49_05655	COG0583	DNA-binding transcription factor activity
C4X49_05695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4X49_05700	COG0741	lytic transglycosylase activity
C4X49_05700	COG0741	lytic transglycosylase activity
C4X49_05700	COG1388	LysM domain
C4X49_05700	COG1388	LysM domain
C4X49_05710	COG4174	ABC transporter (Permease)
C4X49_05715	COG4239	(ABC) transporter, permease
C4X49_05720	COG4172	Belongs to the ABC transporter superfamily
C4X49_05740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4X49_05750	COG3706	GGDEF domain
C4X49_05750	COG2203	Gaf domain
C4X49_05750	COG4251	negative regulation of phosphorylation
C4X49_05750	COG5001	Diguanylate cyclase
C4X49_05760	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4X49_05760	COG1902	pentaerythritol trinitrate reductase activity
C4X49_05835	COG4983	Phage plasmid primase, P4 family domain protein
C4X49_05865	COG1113	amino acid transport
C4X49_05910	COG0697	spore germination
C4X49_05915	COG2721	sulfolactate sulfo-lyase activity
C4X49_05920	COG2271	Major facilitator Superfamily
C4X49_05925	COG4948	Mandelate Racemase Muconate Lactonizing
C4X49_05935	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_05940	COG2186	Transcriptional regulator
C4X49_05965	COG1960	acyl-CoA dehydrogenase activity
C4X49_05975	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_05980	COG1024	Enoyl-CoA hydratase
C4X49_05985	COG2814	Major facilitator Superfamily
C4X49_06000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4X49_06050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C4X49_06060	COG0583	DNA-binding transcription factor activity
C4X49_06065	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C4X49_06070	COG2072	flavoprotein involved in K transport
C4X49_06075	COG0300	oxidoreductase activity
C4X49_06085	COG1309	transcriptional regulator
C4X49_06090	COG1741	Belongs to the pirin family
C4X49_06105	COG2072	flavoprotein involved in K transport
C4X49_06115	COG2252	PERMEase
C4X49_06120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4X49_06135	COG3038	cytochrome b561
C4X49_06145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4X49_06180	COG3620	sequence-specific DNA binding
C4X49_06255	COG3179	chitinase
C4X49_06300	COG3328	transposase activity
C4X49_06305	COG0582	viral genome integration into host DNA
C4X49_06315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4X49_06325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4X49_06340	COG0667	Aldo Keto reductase
C4X49_06350	COG1765	OsmC-like protein
C4X49_06400	COG2885	chlorophyll binding
C4X49_06410	COG0625	glutathione transferase activity
C4X49_06435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4X49_06455	COG3634	alkyl hydroperoxide reductase activity
C4X49_06465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4X49_06475	COG0450	alkyl hydroperoxide reductase
C4X49_06480	COG1643	Atp-dependent helicase
C4X49_06495	COG2814	Major facilitator Superfamily
C4X49_06500	COG3135	benzoate transporter
C4X49_06505	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_06510	COG0633	Ferredoxin
C4X49_06510	COG0543	2 iron, 2 sulfur cluster binding
C4X49_06515	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C4X49_06520	COG4638	Rieske (2fe-2S)
C4X49_06525	COG0583	DNA-binding transcription factor activity
C4X49_06580	COG1570	exodeoxyribonuclease VII activity
C4X49_06615	COG1280	lysine exporter protein (LysE YggA)
C4X49_06620	COG1278	Cold shock
C4X49_06660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C4X49_06660	COG0517	IMP dehydrogenase activity
C4X49_06665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4X49_06675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C4X49_06680	COG1137	ATPase activity
C4X49_06705	COG1538	Outer membrane efflux protein
C4X49_06745	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C4X49_06760	COG1522	sequence-specific DNA binding
C4X49_06785	COG1560	Kdo2-lipid A biosynthetic process
C4X49_06795	COG2814	Major facilitator Superfamily
C4X49_06805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C4X49_06810	COG1116	anion transmembrane transporter activity
C4X49_06815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4X49_06820	COG4521	taurine ABC transporter
C4X49_06840	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4X49_06860	COG1011	Hydrolase
C4X49_06880	COG0583	DNA-binding transcription factor activity
C4X49_06885	COG1914	H( )-stimulated, divalent metal cation uptake system
C4X49_06905	COG4770	biotin carboxylase activity
C4X49_06910	COG0038	chloride channel
C4X49_06935	COG1063	alcohol dehydrogenase
C4X49_06950	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C4X49_06970	COG0789	Transcriptional regulator
C4X49_06985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4X49_07005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C4X49_07030	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_07035	COG0531	amino acid
C4X49_07045	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_07045	COG2030	dehydratase
C4X49_07050	COG3396	Phenylacetate-CoA oxygenase
C4X49_07055	COG3460	Phenylacetate-CoA oxygenase
C4X49_07060	COG3396	Phenylacetate-CoA oxygenase
C4X49_07065	COG2151	metal-sulfur cluster biosynthetic enzyme
C4X49_07070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4X49_07075	COG1024	Enoyl-CoA hydratase
C4X49_07080	COG1024	Enoyl-CoA hydratase
C4X49_07085	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4X49_07090	COG0183	Belongs to the thiolase family
C4X49_07095	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C4X49_07100	COG3327	negative regulation of DNA-templated transcription, initiation
C4X49_07110	COG2050	protein possibly involved in aromatic compounds catabolism
C4X49_07120	COG0406	alpha-ribazole phosphatase activity
C4X49_07145	COG1309	transcriptional regulator
C4X49_07150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4X49_07165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4X49_07170	COG0531	amino acid
C4X49_07180	COG0753	catalase activity
C4X49_07185	COG3038	cytochrome b561
C4X49_07205	COG2267	carboxylic ester hydrolase activity
C4X49_07210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_07215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4X49_07220	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_07230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C4X49_07240	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_07255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4X49_07260	COG0583	DNA-binding transcription factor activity
C4X49_07270	COG1414	Transcriptional regulator
C4X49_07275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4X49_07285	COG1840	ABC-type Fe3 transport system, periplasmic component
C4X49_07290	COG3842	ATPase activity
C4X49_07305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C4X49_07310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4X49_07315	COG2814	Major facilitator Superfamily
C4X49_07320	COG1960	acyl-CoA dehydrogenase activity
C4X49_07335	COG1024	Enoyl-CoA hydratase
C4X49_07350	COG2814	Major facilitator Superfamily
C4X49_07360	COG0183	Belongs to the thiolase family
C4X49_07365	COG1250	3-hydroxyacyl-CoA dehydrogenase
C4X49_07370	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_07375	COG1024	Enoyl-CoA hydratase
C4X49_07380	COG1960	acyl-CoA dehydrogenase activity
C4X49_07385	COG2814	Major facilitator Superfamily
C4X49_07390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4X49_07395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4X49_07405	COG2814	Major facilitator Superfamily
C4X49_07415	COG1960	acyl-CoA dehydrogenase activity
C4X49_07430	COG0583	DNA-binding transcription factor activity
C4X49_07445	COG1024	Enoyl-CoA hydratase
C4X49_07450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4X49_07455	COG1960	acyl-CoA dehydrogenase activity
C4X49_07460	COG1309	transcriptional regulator
C4X49_07465	COG0318	PFAM AMP-dependent synthetase and ligase
C4X49_07485	COG0583	DNA-binding transcription factor activity
C4X49_07530	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_07550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C4X49_07570	COG0784	Response regulator, receiver
C4X49_07570	COG2205	protein histidine kinase activity
C4X49_07615	COG0765	amino acid transport
C4X49_07620	COG0765	amino acid transport
C4X49_07625	COG1126	abc transporter atp-binding protein
C4X49_07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4X49_07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C4X49_07650	COG1280	lysine exporter protein (LysE YggA)
C4X49_07655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C4X49_07660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4X49_07665	COG1045	serine acetyltransferase
C4X49_07680	COG0583	DNA-binding transcription factor activity
C4X49_07685	COG0625	glutathione transferase activity
C4X49_07690	COG0625	glutathione transferase activity
C4X49_07695	COG0583	DNA-binding transcription factor activity
C4X49_07705	COG1346	cytolysis
C4X49_07730	COG0300	oxidoreductase activity
C4X49_07735	COG2814	Major facilitator Superfamily
C4X49_07745	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C4X49_07750	COG3052	prosthetic group binding
C4X49_07770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4X49_07790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4X49_07800	COG1294	oxidase, subunit
C4X49_07805	COG1271	oxidase subunit
C4X49_07835	COG0477	Major facilitator Superfamily
C4X49_07845	COG4521	taurine ABC transporter
C4X49_07850	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C4X49_07855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4X49_07860	COG2175	clavaminate synthase activity
C4X49_07870	COG1953	Uracil, thiamine, allantoin
C4X49_07880	COG0583	DNA-binding transcription factor activity
C4X49_07890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C4X49_07905	COG0640	Transcriptional regulator
C4X49_07910	COG0798	PFAM Bile acid sodium symporter
C4X49_07915	COG0583	DNA-binding transcription factor activity
C4X49_07930	COG3634	alkyl hydroperoxide reductase activity
C4X49_07970	COG0436	Aminotransferase
C4X49_07980	COG0386	Belongs to the glutathione peroxidase family
C4X49_08020	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4X49_08045	COG0012	GTP binding
C4X49_08050	COG2011	ABC-type metal ion transport system permease component
C4X49_08055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4X49_08065	COG1464	Belongs to the NlpA lipoprotein family
C4X49_08095	COG0765	amino acid transport
C4X49_08100	COG0765	amino acid transport
C4X49_08105	COG1126	abc transporter atp-binding protein
C4X49_08115	COG1522	sequence-specific DNA binding
C4X49_08185	COG3121	Chaperone
C4X49_08190	COG3539	Fimbrial protein
C4X49_08215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4X49_08215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4X49_08260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4X49_08270	COG2353	YceI-like domain
C4X49_08280	COG3698	Phosphodiester glycosidase
C4X49_08295	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C4X49_08300	COG0506	proline dehydrogenase activity
C4X49_08300	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4X49_08300	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4X49_08310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4X49_08315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C4X49_08335	COG1132	(ABC) transporter
C4X49_08340	COG3122	Protein conserved in bacteria
C4X49_08345	COG3619	membrane
C4X49_08355	COG0640	Transcriptional regulator
C4X49_08365	COG2850	peptidyl-arginine hydroxylation
C4X49_08370	COG0424	maF-like protein
C4X49_08390	COG0191	fructose-bisphosphate aldolase activity
C4X49_08395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4X49_08410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4X49_08420	COG1192	Involved in chromosome partitioning
C4X49_08425	COG1475	DNA binding
C4X49_08430	COG0811	peptide transport
C4X49_08440	COG1132	(ABC) transporter
C4X49_08445	COG1663	tetraacyldisaccharide 4'-kinase activity
C4X49_08465	COG0084	hydrolase, TatD family'
C4X49_08480	COG2165	general secretion pathway protein
C4X49_08510	COG0590	tRNA wobble adenosine to inosine editing
C4X49_08530	COG0776	regulation of translation
C4X49_08570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C4X49_08605	COG0339	signal peptide processing
C4X49_08615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C4X49_08650	COG0702	epimerase
C4X49_08655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4X49_08675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4X49_08705	COG0316	Belongs to the HesB IscA family
C4X49_08710	COG0822	iron-sulfur transferase activity
C4X49_08735	COG0776	regulation of translation
C4X49_08740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4X49_08745	COG2207	Transcriptional regulator
C4X49_08750	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4X49_08755	COG1960	acyl-CoA dehydrogenase activity
C4X49_08760	COG1960	acyl-CoA dehydrogenase activity
C4X49_08775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C4X49_08795	COG4264	IucA IucC family
C4X49_08800	COG4264	IucA IucC family
C4X49_08810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C4X49_08840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4X49_08855	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C4X49_08860	COG0406	alpha-ribazole phosphatase activity
C4X49_08875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4X49_08880	COG0730	response to heat
C4X49_08905	COG4773	Receptor
C4X49_08910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4X49_08925	COG1131	(ABC) transporter
C4X49_08930	COG0842	Transport permease protein
C4X49_08935	COG0842	Transport permease protein
C4X49_08990	COG2226	methyltransferase
C4X49_09020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4X49_09055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4X49_09065	COG0133	tryptophan synthase activity
C4X49_09080	COG3706	GGDEF domain
C4X49_09095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4X49_09105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4X49_09110	COG0022	dehydrogenase e1 component
C4X49_09115	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4X49_09120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4X49_09130	COG1063	alcohol dehydrogenase
C4X49_09135	COG3781	membrane
C4X49_09145	COG3453	Protein conserved in bacteria
C4X49_09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4X49_09155	COG0730	response to heat
C4X49_09170	COG2207	Transcriptional regulator
C4X49_09170	COG3708	Transcriptional regulator
C4X49_09175	COG1733	regulation of RNA biosynthetic process
C4X49_09180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C4X49_09205	COG4521	taurine ABC transporter
C4X49_09220	COG0477	Major facilitator Superfamily
C4X49_09230	COG1027	Aspartate ammonia-lyase
C4X49_09245	COG0583	DNA-binding transcription factor activity
C4X49_09250	COG0583	DNA-binding transcription factor activity
C4X49_09255	COG0183	Belongs to the thiolase family
C4X49_09260	COG2031	fatty acid transporter
C4X49_09275	COG0583	DNA-binding transcription factor activity
C4X49_09295	COG1309	transcriptional regulator
C4X49_09305	COG2610	gluconate transmembrane transporter activity
C4X49_09310	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09315	COG2207	Transcriptional regulator
C4X49_09325	COG0412	Dienelactone hydrolase
C4X49_09330	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_09355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4X49_09355	COG0543	2 iron, 2 sulfur cluster binding
C4X49_09375	COG0725	ABC transporter, periplasmic molybdate-binding protein
C4X49_09380	COG4149	molybdate abc transporter
C4X49_09385	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4X49_09390	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09395	COG1535	isochorismatase
C4X49_09395	COG3433	isochorismatase activity
C4X49_09465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4X49_09480	COG0753	catalase activity
C4X49_09490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4X49_09515	COG3539	Fimbrial protein
C4X49_09570	COG0318	PFAM AMP-dependent synthetase and ligase
C4X49_09580	COG1960	acyl-CoA dehydrogenase activity
C4X49_09590	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09595	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09600	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09605	COG0583	DNA-binding transcription factor activity
C4X49_09610	COG1309	transcriptional regulator
C4X49_09640	COG3231	kanamycin kinase activity
C4X49_09645	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_09665	COG2186	Transcriptional regulator
C4X49_09675	COG0583	DNA-binding transcription factor activity
C4X49_09680	COG4948	Mandelate Racemase Muconate Lactonizing
C4X49_09685	COG4829	muconolactone delta-isomerase
C4X49_09695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4X49_09700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4X49_09705	COG0183	Belongs to the thiolase family
C4X49_09710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4X49_09720	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_09730	COG3733	amine oxidase
C4X49_09740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_09750	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_09760	COG4638	Rieske (2fe-2S)
C4X49_09780	COG0154	amidase activity
C4X49_09790	COG2814	Major facilitator Superfamily
C4X49_09815	COG1960	acyl-CoA dehydrogenase activity
C4X49_09820	COG0583	DNA-binding transcription factor activity
C4X49_09825	COG1414	Transcriptional regulator
C4X49_09840	COG2391	methyltransferase activity
C4X49_09850	COG4993	Dehydrogenase
C4X49_09855	COG3659	wide pore channel activity
C4X49_09860	COG3420	alginic acid biosynthetic process
C4X49_09865	COG0710	3-dehydroquinate dehydratase activity
C4X49_09870	COG3485	protocatechuate 3,4-dioxygenase
C4X49_09875	COG3485	protocatechuate 3,4-dioxygenase
C4X49_09880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C4X49_09885	COG2271	Major facilitator Superfamily
C4X49_09890	COG0596	Alpha beta hydrolase
C4X49_09895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C4X49_09900	COG0183	Belongs to the thiolase family
C4X49_09905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C4X49_09910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C4X49_09920	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C4X49_09925	COG2323	membrane
C4X49_09970	COG1902	pentaerythritol trinitrate reductase activity
C4X49_09970	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4X49_09985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C4X49_09995	COG0542	response to heat
C4X49_10000	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4X49_10030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4X49_10035	COG0569	domain protein
C4X49_10040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C4X49_10060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4X49_10070	COG1585	Membrane protein implicated in regulation of membrane protease activity
C4X49_10085	COG1294	oxidase, subunit
C4X49_10090	COG4890	Cyd operon protein YbgT
C4X49_10105	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C4X49_10115	COG0552	protein localization to endoplasmic reticulum
C4X49_10140	COG0517	IMP dehydrogenase activity
C4X49_10140	COG0516	GMP reductase activity
C4X49_10145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4X49_10150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4X49_10160	COG0583	DNA-binding transcription factor activity
C4X49_10165	COG0024	Methionine aminopeptidase
C4X49_10195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4X49_10195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4X49_10200	COG1105	Belongs to the carbohydrate kinase PfkB family
C4X49_10205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4X49_10205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C4X49_10205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C4X49_10240	COG1113	amino acid transport
C4X49_10250	COG1522	sequence-specific DNA binding
C4X49_10275	COG1011	Hydrolase
C4X49_10280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C4X49_10290	COG2137	regulation of response to DNA damage stimulus
C4X49_10305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4X49_10325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4X49_10340	COG0575	Belongs to the CDS family
C4X49_10345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4X49_10365	COG3852	Histidine kinase
C4X49_10370	COG2204	response regulator
C4X49_10430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4X49_10435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C4X49_10455	COG0697	spore germination
C4X49_10460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4X49_10470	COG0303	'Molybdopterin
C4X49_10475	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4X49_10475	COG0315	cyclic pyranopterin monophosphate synthase activity
C4X49_10490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4X49_10495	COG0243	molybdopterin cofactor binding
C4X49_10505	COG0243	molybdopterin cofactor binding
C4X49_10510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4X49_10515	COG2146	nitrite reductase [NAD(P)H] activity
C4X49_10515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4X49_10525	COG0745	RESPONSE REGULATOR receiver
C4X49_10530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4X49_10530	COG1116	anion transmembrane transporter activity
C4X49_10545	COG1196	nuclear chromosome segregation
C4X49_10575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4X49_10585	COG0511	ligase activity, forming carbon-carbon bonds
C4X49_10600	COG2814	Major facilitator Superfamily
C4X49_10820	COG0069	glutamate synthase activity
C4X49_10840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4X49_10850	COG1454	alcohol dehydrogenase
C4X49_10855	COG0824	Thioesterase
C4X49_10865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C4X49_10895	COG0183	Belongs to the thiolase family
C4X49_10905	COG0583	DNA-binding transcription factor activity
C4X49_10920	COG1522	sequence-specific DNA binding
C4X49_10925	COG3135	benzoate transporter
C4X49_10955	COG0589	response to stress
C4X49_10960	COG0488	(ABC) transporter
C4X49_10980	COG4773	Receptor
C4X49_10995	COG3328	transposase activity
C4X49_11015	COG0668	transmembrane transport
C4X49_11025	COG1309	transcriptional regulator
C4X49_11045	COG1605	Chorismate mutase
C4X49_11065	COG0308	aminopeptidase N
C4X49_11085	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C4X49_11095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4X49_11100	COG1454	alcohol dehydrogenase
C4X49_11120	COG0531	amino acid
C4X49_11125	COG4303	Ethanolamine ammonia lyase large subunit
C4X49_11130	COG4302	ethanolamine ammonia-lyase activity
C4X49_11135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4X49_11135	COG0519	Catalyzes the synthesis of GMP from XMP
C4X49_11150	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4X49_11165	COG0697	spore germination
C4X49_11170	COG1923	regulation of RNA biosynthetic process
C4X49_11180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C4X49_11185	COG0802	atpase or kinase
C4X49_11205	COG1187	pseudouridine synthase activity
C4X49_11220	COG0583	DNA-binding transcription factor activity
C4X49_11235	COG2814	Major facilitator Superfamily
C4X49_11240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C4X49_11270	COG0729	surface antigen
C4X49_11290	COG0174	glutamine synthetase
C4X49_11295	COG0745	RESPONSE REGULATOR receiver
C4X49_11300	COG2205	protein histidine kinase activity
C4X49_11310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4X49_11315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4X49_11340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_11345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4X49_11350	COG1960	acyl-CoA dehydrogenase activity
C4X49_11365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4X49_11370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4X49_11385	COG3328	transposase activity
C4X49_11395	COG0583	DNA-binding transcription factor activity
C4X49_11415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4X49_11425	COG3658	cytochrome
C4X49_11430	COG1215	transferase activity, transferring glycosyl groups
C4X49_11435	COG1649	PFAM Uncharacterised BCR, COG1649
C4X49_11435	COG0726	polysaccharide deacetylase
C4X49_11460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4X49_11465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4X49_11475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C4X49_11500	COG0305	Participates in initiation and elongation during chromosome replication
C4X49_11505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4X49_11515	COG1305	Transglutaminase-like
C4X49_11525	COG2308	Evidence 4 Homologs of previously reported genes of
C4X49_11555	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C4X49_11560	COG0138	bifunctional purine biosynthesis protein purh
C4X49_11565	COG0151	Belongs to the GarS family
C4X49_11570	COG1464	Belongs to the NlpA lipoprotein family
C4X49_11575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C4X49_11580	COG2011	ABC-type metal ion transport system permease component
C4X49_11585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4X49_11595	COG1301	dicarboxylic acid transport
C4X49_11635	COG1794	racemase activity, acting on amino acids and derivatives
C4X49_11650	COG3008	intermembrane lipid transfer
C4X49_11650	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4X49_11655	COG2995	paraquat-inducible protein a
C4X49_11680	COG0477	Major facilitator Superfamily
C4X49_11735	COG2186	Transcriptional regulator
C4X49_11745	COG0786	glutamate:sodium symporter activity
C4X49_11750	COG3243	poly(R)-hydroxyalkanoic acid synthase
C4X49_11775	COG3111	PFAM Bacterial OB fold (BOF) protein
C4X49_11785	COG2226	methyltransferase
C4X49_11870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4X49_11875	COG1610	YqeY-like protein
C4X49_11880	COG4783	chaperone-mediated protein folding
C4X49_11905	COG1286	toxin biosynthetic process
C4X49_12020	COG0778	Nitroreductase
C4X49_12030	COG0513	Belongs to the DEAD box helicase family
C4X49_12050	COG2363	Small membrane protein
C4X49_12100	COG2195	Cleaves the N-terminal amino acid of tripeptides
C4X49_12110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4X49_12125	COG1960	acyl-CoA dehydrogenase activity
C4X49_12130	COG1301	dicarboxylic acid transport
C4X49_12140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4X49_12145	COG3139	Protein of unknown function (DUF1315)
C4X49_12150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4X49_12155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4X49_12165	COG0494	nUDIX hydrolase
C4X49_12175	COG0642	Histidine kinase
C4X49_12180	COG0745	RESPONSE REGULATOR receiver
C4X49_12185	COG3111	PFAM Bacterial OB fold (BOF) protein
C4X49_12200	COG1720	tRNA m6t6A37 methyltransferase activity
C4X49_12215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C4X49_12225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4X49_12235	COG4598	ABC transporter
C4X49_12240	COG4160	amino acid transport
C4X49_12245	COG4215	(ABC) transporter
C4X49_12260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4X49_12270	COG1538	Outer membrane efflux protein
C4X49_12305	COG1131	(ABC) transporter
C4X49_12310	COG0842	Transport permease protein
C4X49_12325	COG0772	Belongs to the SEDS family
C4X49_12330	COG2951	lytic endotransglycosylase activity
C4X49_12355	COG2207	Transcriptional regulator
C4X49_12370	COG0052	Belongs to the universal ribosomal protein uS2 family
C4X49_12375	COG0024	Methionine aminopeptidase
C4X49_12385	COG2223	nitrite transmembrane transporter activity
C4X49_12395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4X49_12400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4X49_12405	COG1960	acyl-CoA dehydrogenase activity
C4X49_12420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4X49_12425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4X49_12430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4X49_12435	COG3328	transposase activity
C4X49_12455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4X49_12460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4X49_12465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C4X49_12500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4X49_12515	COG3104	oligopeptide transport
C4X49_12525	COG0512	Glutamine amidotransferase of anthranilate synthase
C4X49_12530	COG0308	aminopeptidase N
C4X49_12560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C4X49_12590	COG3739	integral membrane protein
C4X49_12620	COG5265	(ABC) transporter
C4X49_12640	COG3433	isochorismatase activity
C4X49_12640	COG1535	isochorismatase
C4X49_12645	COG1021	2,3-dihydroxybenzoate-AMP ligase
C4X49_12650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4X49_12660	COG4774	siderophore transport
C4X49_12665	COG4607	ABC-type enterochelin transport system periplasmic component
C4X49_12675	COG4605	iron ion homeostasis
C4X49_12680	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C4X49_12685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4X49_12700	COG2964	Protein conserved in bacteria
C4X49_12710	COG1741	Belongs to the pirin family
C4X49_12735	COG2879	small protein
C4X49_12740	COG1966	Carbon starvation protein
C4X49_12760	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4X49_12785	COG1067	ATP-dependent peptidase activity
C4X49_12790	COG0583	DNA-binding transcription factor activity
C4X49_12815	COG1686	Belongs to the peptidase S11 family
C4X49_12820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C4X49_12855	COG0616	signal peptide processing
C4X49_12860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4X49_12870	COG0573	inorganic phosphate transmembrane transporter activity
C4X49_12875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4X49_12880	COG1113	amino acid transport
C4X49_12885	COG3961	Belongs to the TPP enzyme family
C4X49_12890	COG1522	sequence-specific DNA binding
C4X49_12900	COG0076	glutamate decarboxylase activity
C4X49_12905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4X49_12930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4X49_12965	COG0352	thiamine-phosphate diphosphorylase activity
C4X49_12990	COG0612	Peptidase, M16
C4X49_13005	COG0583	DNA-binding transcription factor activity
C4X49_13010	COG0477	Major facilitator Superfamily
C4X49_13035	COG1187	pseudouridine synthase activity
C4X49_13050	COG1686	Belongs to the peptidase S11 family
C4X49_13055	COG1252	NADH dehydrogenase
C4X49_13065	COG0415	Belongs to the DNA photolyase family
C4X49_13080	COG1215	transferase activity, transferring glycosyl groups
C4X49_13110	COG2070	2-Nitropropane dioxygenase
C4X49_13165	COG0556	nucleotide-excision repair
C4X49_13195	COG0443	Heat shock 70 kDa protein
C4X49_13225	COG4221	oxidoreductase activity
C4X49_13235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C4X49_13240	COG1381	Involved in DNA repair and RecF pathway recombination
C4X49_13250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4X49_13265	COG0681	Belongs to the peptidase S26 family
C4X49_13275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C4X49_13285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4X49_13305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4X49_13310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4X49_13315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C4X49_13325	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C4X49_13330	COG4208	sulfate ABC transporter
C4X49_13335	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C4X49_13340	COG0583	DNA-binding transcription factor activity
C4X49_13345	COG4625	pathogenesis
C4X49_13360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4X49_13375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4X49_13385	COG1051	belongs to the nudix hydrolase family
C4X49_13385	COG1056	cytidyltransferase-related domain
C4X49_13390	COG1024	Enoyl-CoA hydratase
C4X49_13395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C4X49_13400	COG2814	Major facilitator Superfamily
C4X49_13405	COG0047	phosphoribosylformylglycinamidine synthase activity
C4X49_13405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4X49_13425	COG1473	amidohydrolase
C4X49_13430	COG0824	Thioesterase
C4X49_13450	COG0823	Involved in the tonB-independent uptake of proteins
C4X49_13470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4X49_13515	COG0628	permease
C4X49_13525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4X49_13530	COG0596	Alpha beta hydrolase
C4X49_13535	COG0616	signal peptide processing
C4X49_13535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4X49_13545	COG2333	competence protein COMEC
C4X49_13545	COG0658	competence protein
C4X49_13550	COG1136	(ABC) transporter
C4X49_13555	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4X49_13585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4X49_13605	COG0463	Glycosyl transferase, family 2
C4X49_13635	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4X49_13640	COG1280	lysine exporter protein (LysE YggA)
C4X49_13650	COG0019	diaminopimelate decarboxylase activity
C4X49_13660	COG1113	amino acid transport
C4X49_13675	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C4X49_13685	COG3339	Conserved Protein
C4X49_13690	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4X49_13695	COG0243	molybdopterin cofactor binding
C4X49_13700	COG1929	Belongs to the glycerate kinase type-1 family
C4X49_13715	COG0778	Nitroreductase
C4X49_13745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4X49_13805	COG2132	Multicopper oxidase
C4X49_13820	COG2205	protein histidine kinase activity
C4X49_13825	COG2217	Heavy metal translocating P-type atpase
C4X49_13865	COG0582	viral genome integration into host DNA
C4X49_13875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4X49_13900	COG0741	lytic transglycosylase activity
C4X49_13920	COG0584	glycerophosphoryl diester phosphodiesterase
C4X49_13925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4X49_13955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C4X49_13975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4X49_13985	COG0477	Major facilitator Superfamily
C4X49_14035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4X49_14040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4X49_14065	COG0505	Belongs to the CarA family
C4X49_14085	COG0589	response to stress
C4X49_14100	COG2843	Capsule synthesis protein
C4X49_14115	COG2321	neutral zinc metallopeptidase
C4X49_14120	COG2354	Protein conserved in bacteria
C4X49_14140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4X49_14165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4X49_14170	COG1053	succinate dehydrogenase
C4X49_14175	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C4X49_14180	COG2009	succinate dehydrogenase
C4X49_14215	COG2921	Belongs to the UPF0250 family
C4X49_14220	COG0321	lipoyl(octanoyl) transferase activity
C4X49_14235	COG0531	amino acid
C4X49_14245	COG1733	regulation of RNA biosynthetic process
C4X49_14250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C4X49_14255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4X49_14255	COG1648	precorrin-2 dehydrogenase activity
C4X49_14270	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4X49_14300	COG0671	phosphoesterase, PA-phosphatase related
C4X49_14305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4X49_14315	COG1538	Outer membrane efflux protein
C4X49_14320	COG0393	Putative heavy-metal-binding
C4X49_14325	COG0393	Putative heavy-metal-binding
C4X49_14335	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_14345	COG0525	valine-tRNA ligase activity
C4X49_14365	COG0583	DNA-binding transcription factor activity
C4X49_14375	COG0004	ammonium transporteR
C4X49_14385	COG0642	Histidine kinase
C4X49_14390	COG0745	RESPONSE REGULATOR receiver
C4X49_14395	COG2194	sulfuric ester hydrolase activity
C4X49_14415	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4X49_14430	COG2315	Protein conserved in bacteria
C4X49_14435	COG0142	geranyltranstransferase activity
C4X49_14440	COG2828	Protein conserved in bacteria
C4X49_14445	COG1113	amino acid transport
C4X49_14465	COG2207	Transcriptional regulator
C4X49_14490	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4X49_14510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4X49_14520	COG1530	ribonuclease E activity
C4X49_14525	COG0424	maF-like protein
C4X49_14530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C4X49_14535	COG1792	Involved in formation and maintenance of cell shape
C4X49_14540	COG1077	Cell shape determining protein MreB Mrl
C4X49_14545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4X49_14555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4X49_14580	COG3590	peptidase
C4X49_14610	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C4X49_14615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4X49_14620	COG1752	Esterase of the alpha-beta hydrolase superfamily
C4X49_14625	COG1115	amino acid carrier protein
C4X49_14645	COG2814	Major facilitator Superfamily
C4X49_14650	COG1289	transmembrane transporter activity
C4X49_14700	COG1376	ErfK ybiS ycfS ynhG family protein
C4X49_14705	COG2832	Protein of unknown function (DUF454)
C4X49_14715	COG5510	response to toxic substance
C4X49_14730	COG0840	transmembrane signaling receptor activity
C4X49_14770	COG3422	double-strand break repair
C4X49_14775	COG2824	Alkylphosphonate utilization operon protein PhnA
C4X49_14780	COG3189	MarR family transcriptional regulator
C4X49_14785	COG0596	Alpha beta hydrolase
C4X49_14790	COG0778	Nitroreductase
C4X49_14795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C4X49_14800	COG1335	isochorismatase
C4X49_14805	COG0251	oxidation-reduction process
C4X49_14810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_14815	COG2233	PERMEase
C4X49_14830	COG0354	folic acid binding
C4X49_14835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4X49_14850	COG1902	pentaerythritol trinitrate reductase activity
C4X49_14855	COG4772	TonB-dependent receptor
C4X49_14875	COG2094	Belongs to the DNA glycosylase MPG family
C4X49_14905	COG2233	PERMEase
C4X49_14915	COG0833	amino acid
C4X49_14920	COG1690	Belongs to the RtcB family
C4X49_14930	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C4X49_14930	COG2885	chlorophyll binding
C4X49_14940	COG0183	Belongs to the thiolase family
C4X49_14960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4X49_14980	COG2207	Transcriptional regulator
C4X49_14985	COG0183	Belongs to the thiolase family
C4X49_15015	COG1272	protein, Hemolysin III
C4X49_15020	COG0477	Major facilitator Superfamily
C4X49_15035	COG0450	alkyl hydroperoxide reductase
C4X49_15055	COG0285	dihydrofolate synthase activity
C4X49_15095	COG0133	tryptophan synthase activity
C4X49_15110	COG2096	Adenosyltransferase
C4X49_15130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C4X49_15135	COG0745	RESPONSE REGULATOR receiver
C4X49_15140	COG2205	protein histidine kinase activity
C4X49_15155	COG1960	acyl-CoA dehydrogenase activity
C4X49_15160	COG1960	acyl-CoA dehydrogenase activity
C4X49_15210	COG1215	transferase activity, transferring glycosyl groups
C4X49_15225	COG1091	dTDP-4-dehydrorhamnose reductase activity
C4X49_15240	COG0438	transferase activity, transferring glycosyl groups
C4X49_15245	COG0726	polysaccharide deacetylase
C4X49_15260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C4X49_15265	COG2205	protein histidine kinase activity
C4X49_15270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C4X49_15285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C4X49_15320	COG0582	viral genome integration into host DNA
C4X49_15350	COG1862	Preprotein translocase
C4X49_15360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4X49_15375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4X49_15385	COG3781	membrane
C4X49_15390	COG0613	PHP domain protein
C4X49_15400	COG2350	Protein conserved in bacteria
C4X49_15430	COG1607	acyl-coa hydrolase
C4X49_15445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4X49_15445	COG3453	Protein conserved in bacteria
C4X49_15490	COG2199	diguanylate cyclase activity
C4X49_15500	COG1408	metallophosphoesterase
C4X49_15505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4X49_15515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4X49_15535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4X49_15540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4X49_15555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4X49_15565	COG2969	positive regulation of protein catabolic process
C4X49_15585	COG1960	acyl-CoA dehydrogenase activity
C4X49_15590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C4X49_15605	COG1309	transcriptional regulator
C4X49_15610	COG1960	acyl-CoA dehydrogenase activity
C4X49_15655	COG1183	phosphatidylcholine synthase activity
C4X49_15660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4X49_15690	COG0741	lytic transglycosylase activity
C4X49_15690	COG0739	heme binding
C4X49_15690	COG1196	nuclear chromosome segregation
C4X49_15700	COG1702	phosphate starvation-inducible protein PhoH
C4X49_15735	COG1295	ribonuclease BN
C4X49_15740	COG0697	spore germination
C4X49_15745	COG2169	Transcriptional regulator
C4X49_15750	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4X49_15795	COG0557	exoribonuclease II activity
C4X49_15800	COG0339	signal peptide processing
C4X49_15805	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C4X49_15820	COG3328	transposase activity
C4X49_15845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4X49_15850	COG1960	acyl-CoA dehydrogenase activity
C4X49_15875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4X49_15885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4X49_16005	COG0626	cystathionine gamma-synthase activity
C4X49_16010	COG0433	COG0433 Predicted ATPase
C4X49_16020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4X49_16020	COG1017	nitric oxide dioxygenase activity
C4X49_16025	COG1959	2 iron, 2 sulfur cluster binding
C4X49_16040	COG1301	dicarboxylic acid transport
C4X49_16045	COG1946	Acyl-CoA thioesterase
C4X49_16065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4X49_16070	COG1040	competence protein
C4X49_16075	COG0494	nUDIX hydrolase
C4X49_16085	COG0598	Magnesium transport protein CorA
C4X49_16095	COG2854	intermembrane phospholipid transfer
C4X49_16105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4X49_16110	COG1127	ABC transporter
C4X49_16115	COG0513	Belongs to the DEAD box helicase family
C4X49_16150	COG1960	acyl-CoA dehydrogenase activity
C4X49_16160	COG1983	PspC domain protein
C4X49_16165	COG0517	IMP dehydrogenase activity
C4X49_16215	COG0583	DNA-binding transcription factor activity
C4X49_16220	COG3316	Transposase and inactivated derivatives
C4X49_16225	COG1063	alcohol dehydrogenase
C4X49_16230	COG4716	Myosin-crossreactive antigen
C4X49_16240	COG3316	Transposase and inactivated derivatives
C4X49_16255	COG3316	Transposase and inactivated derivatives
C4X49_16280	COG0789	Transcriptional regulator
C4X49_16305	COG0789	Transcriptional regulator
C4X49_16310	COG3316	Transposase and inactivated derivatives
C4X49_16320	COG0842	Transport permease protein
C4X49_16355	COG2194	sulfuric ester hydrolase activity
C4X49_16360	COG0745	RESPONSE REGULATOR receiver
C4X49_16370	COG3316	Transposase and inactivated derivatives
C4X49_16405	COG3316	Transposase and inactivated derivatives
C4X49_16410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C4X49_16420	COG0833	amino acid
C4X49_16450	COG1192	Involved in chromosome partitioning
C4X49_16455	COG0628	permease
C4X49_16465	COG1289	transmembrane transporter activity
C4X49_16480	COG2249	NAD(P)H dehydrogenase (quinone) activity
C4X49_16485	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C4X49_16495	COG0277	FAD linked oxidase domain protein
C4X49_16500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4X49_16525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C4X49_16530	COG5380	lipid catabolic process
C4X49_16550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4X49_16600	COG0194	GDP metabolic process
C4X49_16615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4X49_16635	COG3307	-O-antigen
C4X49_16665	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C4X49_16670	COG1704	LemA family
C4X49_16680	COG0493	'glutamate synthase
C4X49_16685	COG0067	glutamate synthase
C4X49_16685	COG0069	glutamate synthase activity
C4X49_16685	COG0070	glutamate synthase
C4X49_16745	COG2226	methyltransferase
C4X49_16760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4X49_16765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4X49_16810	COG0833	amino acid
C4X49_16905	COG0488	(ABC) transporter
C4X49_16915	COG4221	oxidoreductase activity
C4X49_16920	COG0659	secondary active sulfate transmembrane transporter activity
C4X49_16930	COG0745	RESPONSE REGULATOR receiver
C4X49_16945	COG0427	acetyl-CoA hydrolase
C4X49_16975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4X49_17015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4X49_17090	COG0667	Aldo Keto reductase
C4X49_17110	COG0583	DNA-binding transcription factor activity
C4X49_17115	COG2814	Major facilitator Superfamily
C4X49_17125	COG0583	DNA-binding transcription factor activity
C4X49_17135	COG0371	Dehydrogenase
C4X49_17140	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_17145	COG0477	Major facilitator Superfamily
C4X49_17160	COG3328	transposase activity
C4X49_17235	COG3328	transposase activity
C4X49_17245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4X49_17270	COG1335	isochorismatase
C4X49_17280	COG1012	belongs to the aldehyde dehydrogenase family
C4X49_17285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C4X49_17295	COG1113	amino acid transport
C4X49_17305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C4X49_17320	COG2814	Major facilitator Superfamily
C4X49_17330	COG0351	phosphomethylpyrimidine kinase
C4X49_17330	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C4X49_17330	COG0352	thiamine-phosphate diphosphorylase activity
C4X49_17350	COG1309	transcriptional regulator
C4X49_17355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4X49_17360	COG3706	GGDEF domain
C4X49_17370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C4X49_17380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C4X49_17385	COG3162	membrane
C4X49_17390	COG0784	Response regulator, receiver
C4X49_17390	COG2198	Histidine kinase
C4X49_17390	COG2205	protein histidine kinase activity
C4X49_17415	COG1522	sequence-specific DNA binding
C4X49_17420	COG1335	isochorismatase
C4X49_17425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4X49_17435	COG0668	transmembrane transport
C4X49_17440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C4X49_17445	COG1519	Transferase
C4X49_17450	COG1902	pentaerythritol trinitrate reductase activity
C4X49_17470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4X49_17495	COG0426	domain, Protein
C4X49_17495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C4X49_17500	COG4774	siderophore transport
C4X49_17505	COG2119	membrane
C4X49_17515	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4X49_17525	COG4942	peptidase
C4X49_17540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4X49_17550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4X49_17570	COG0189	ligase activity
C4X49_17620	COG0708	Exodeoxyribonuclease III
C4X49_17625	COG1393	Belongs to the ArsC family
C4X49_17645	COG3706	GGDEF domain
C4X49_17680	COG2351	hydroxyisourate hydrolase activity
C4X49_17685	COG2233	PERMEase
C4X49_17695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4X49_17705	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C4X49_17710	COG1028	Short-chain dehydrogenase reductase Sdr
C4X49_17720	COG3150	esterase
C4X49_17750	COG2918	glutathione biosynthetic process
C4X49_17765	COG2733	membrane
C4X49_17770	COG0436	Aminotransferase
C4X49_17775	COG0534	Mate efflux family protein
C4X49_17825	COG0753	catalase activity
C4X49_17875	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4X49_17880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4X49_17890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4X49_17895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4X49_17900	COG0546	phosphoglycolate phosphatase activity
C4X49_17910	COG0010	Belongs to the arginase family
C4X49_17940	COG2188	Transcriptional regulator
C4X49_17950	COG0523	cobalamin synthesis protein
C4X49_17960	COG1113	amino acid transport
C4X49_17970	COG0625	glutathione transferase activity
C4X49_17990	COG1683	Conserved Protein
C4X49_17995	COG0534	Mate efflux family protein
C4X49_18000	COG0385	Bile acid
C4X49_18005	COG1335	isochorismatase
C4X49_18010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4X49_18035	COG2116	formate transmembrane transporter activity
C4X49_18040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4X49_18050	COG2983	Belongs to the UPF0260 family
C4X49_18070	COG1194	a g-specific adenine glycosylase
C4X49_18085	COG2818	Glycosylase
C4X49_18090	COG1064	alcohol dehydrogenase
C4X49_18125	COG0583	DNA-binding transcription factor activity
C4X49_18150	COG2814	Major facilitator Superfamily
C4X49_18185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4X49_18200	COG2233	PERMEase
C4X49_18205	COG0583	DNA-binding transcription factor activity
C4X49_18240	COG0733	neurotransmitter:sodium symporter activity
C4X49_18280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4X49_18340	COG2951	lytic endotransglycosylase activity
C4X49_18345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C4X49_18365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4X49_18375	COG3328	transposase activity
C4X49_18380	COG0671	phosphoesterase, PA-phosphatase related
C4X49_18385	COG0861	Integral membrane protein TerC family
C4X49_18395	COG0754	glutathionylspermidine amidase activity
C4X49_18405	COG0402	S-adenosylhomocysteine deaminase activity
C4X49_18420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C4X49_18425	COG1230	cation diffusion facilitator family transporter
C4X49_18440	COG0706	membrane insertase activity
C4X49_18455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C4X49_18475	COG4372	Transposase
C4X49_18525	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C4X49_18560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4X49_18580	COG3328	transposase activity
C4X49_18585	COG0582	viral genome integration into host DNA
C4X49_18600	COG2130	NADP-dependent
C4X49_18605	COG1309	transcriptional regulator
C4X49_18615	COG1902	pentaerythritol trinitrate reductase activity
C4X49_18625	COG1979	alcohol dehydrogenase
C4X49_18640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4X49_18670	COG0477	Major facilitator Superfamily
C4X49_18675	COG0697	spore germination
C4X49_18685	COG0604	alcohol dehydrogenase
C4X49_18685	COG3321	synthase
C4X49_18690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4X49_18700	COG3328	transposase activity
C4X49_18715	COG3657	addiction module killer protein
C4X49_18720	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4X49_18730	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C4X49_18775	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C4X49_18860	COG1785	Belongs to the alkaline phosphatase family
C4X49_18870	COG1475	DNA binding
C4X49_18875	COG1192	Involved in chromosome partitioning
C4X49_18910	COG0501	Belongs to the peptidase M48B family
C4X49_18915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4X49_18945	COG3316	Transposase and inactivated derivatives
C4X49_18995	COG0542	response to heat
C4X49_19000	COG0071	Belongs to the small heat shock protein (HSP20) family
C4X49_19085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4X49_19155	COG1388	LysM domain
C4X49_19170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4X49_19190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system