locus-tag class description HB366_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HB366_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB366_00030 ENOG4105DQR SNARE associated Golgi HB366_00035 ENOG4105C5H ABC transporter HB366_00040 ENOG4108821 RND type efflux pump HB366_00045 ENOG4108821 RND type efflux pump HB366_00050 ENOG4108821 RND type efflux pump HB366_00060 ENOG4105D74 hydrolase HB366_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HB366_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HB366_00110 ENOG4105C8J )-transporter HB366_00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HB366_00150 ENOG4105C2W permease HB366_00160 ENOG4108IG5 Transcriptional regulator HB366_00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit HB366_00200 ENOG4105F27 Major Facilitator HB366_00205 ENOG4105CV8 reductase HB366_00210 ENOG4105HEI LysR family (Transcriptional regulator HB366_00230 ENOG4105DQ4 alcohol dehydrogenase HB366_00235 ENOG4108R3E Dna-3-methyladenine glycosylase i HB366_00250 ENOG4105CEN a g-specific adenine glycosylase HB366_00270 ENOG4108ZZ3 UPF0260 protein HB366_00280 ENOG4105D1H recombination factor protein RarA HB366_00285 ENOG4105S64 Formate nitrite transporter HB366_00305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB366_00310 ENOG4108RWI nicotinamidase HB366_00315 ENOG4105C09 Bile acid HB366_00320 ENOG4107QI1 Mate efflux family protein HB366_00325 ENOG4105EWC Purine nucleoside phosphorylase HB366_00345 ENOG4108RXX maleylacetoacetate isomerase HB366_00355 ENOG4105C85 amino acid HB366_00365 ENOG4105CKI cobalamin synthesis protein HB366_00375 ENOG4105CZE histidine utilization repressor HB366_00380 ENOG41090B9 response to stress HB366_00395 ENOG4105C85 amino acid HB366_00405 ENOG41088SP formiminoglutamate hydrolase HB366_00420 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HB366_00425 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HB366_00435 ENOG4108ZAI phosphatidylglycerophosphatase a HB366_00440 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HB366_00455 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HB366_00490 ENOG4105KHC sulfurtransferase HB366_00525 ENOG4105BZU Histidine kinase HB366_00530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB366_00545 ENOG4107QJQ Mate efflux family protein HB366_00550 ENOG4105CHM Aminotransferase HB366_00555 ENOG4106BRA Membrane HB366_00570 ENOG4105D9M gamma-glutamylcysteine synthetase HB366_00580 ENOG4105CS6 Rhs element vgr protein HB366_00585 ENOG4105K4H Nlp p60 protein HB366_00600 ENOG4105IPS esterase HB366_00605 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB366_00610 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HB366_00615 ENOG4108Z2U ureidoglycolate hydrolase HB366_00625 ENOG41061H0 Monooxygenase HB366_00640 ENOG41084YZ Hydrolase HB366_00670 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HB366_00675 ENOG4105BZU Histidine kinase HB366_00690 ENOG4105KUZ arsenate reductase HB366_00695 ENOG4105CGK Exodeoxyribonuclease III HB366_00715 ENOG4105D7Z glutathione synthase HB366_00735 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HB366_00740 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HB366_00745 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HB366_00760 ENOG41063SB peptidase HB366_00765 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HB366_00770 ENOG4107QSN dihydrolipoamide acetyltransferase HB366_00785 ENOG4105E0K tonB-dependent siderophore receptor HB366_00800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HB366_00815 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HB366_00835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB366_00840 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HB366_00850 ENOG4105D64 Mechanosensitive ion channel HB366_00860 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HB366_00865 ENOG4108W2Y isochorismatase HB366_00875 ENOG4105D5G Transposase HB366_00880 ENOG4105FBW Monooxygenase HB366_00885 ENOG4108UZX fmn reductase HB366_00900 ENOG4105BZU Histidine kinase HB366_00905 ENOG41062QD Membrane HB366_00910 ENOG4107QN1 sodium solute HB366_00920 ENOG4105C94 Transporter HB366_00930 ENOG4105BZU Histidine kinase HB366_00940 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HB366_00945 ENOG4108WUH Transcriptional regulator, TetR family HB366_00950 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HB366_00960 ENOG4105RA2 Membrane HB366_00965 ENOG4105DWF phosphomethylpyrimidine kinase HB366_00975 ENOG4107RDB Major Facilitator HB366_00980 ENOG4108UUM single-stranded DNA-binding protein HB366_00990 ENOG4108UMN azlc family HB366_01000 ENOG4105C85 amino acid HB366_01010 ENOG4108JPW Aminotransferase HB366_01015 ENOG4105C26 Dehydrogenase HB366_01025 ENOG4105CHJ isochorismatase hydrolase HB366_01030 ENOG4105EUB pirin domain protein HB366_01055 ENOG4105D94 Major Facilitator Superfamily HB366_01060 ENOG4106NZI LysR family Transcriptional regulator HB366_01080 ENOG4105CPC Aldo Keto reductase HB366_01085 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HB366_01110 ENOG4105KVH Transcriptional regulator HB366_01115 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HB366_01180 ENOG4105CUV Homoserine Kinase HB366_01195 ENOG41061CK Antibiotic biosynthesis monooxygenase HB366_01225 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HB366_01250 ENOG4108R6G acetyltransferase HB366_01255 ENOG4105CYC Transferase HB366_01265 ENOG4105E0F Histidine kinase HB366_01280 ENOG4105CHH sulfate transporter HB366_01285 ENOG4105PDP Short chain dehydrogenase HB366_01295 ENOG4105C5H ABC transporter HB366_01380 ENOG4108IQI permease HB366_01405 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HB366_01420 ENOG4105CJN penicillin-binding protein HB366_01425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HB366_01430 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HB366_01445 ENOG4105DHI Methyltransferase HB366_01450 ENOG4108JQC penicillin-binding protein 1A HB366_01475 ENOG4105E4G Type IV pilus HB366_01495 ENOG4105CBC glutamate synthase HB366_01500 ENOG4105BZ8 glutamate synthase HB366_01510 ENOG4108V0P LemA family HB366_01515 ENOG4105HA9 of methanol dehydrogenase type HB366_01535 ENOG4108YSG O-Antigen polymerase HB366_01540 ENOG4108UQY Iron-storage protein HB366_01550 ENOG4105KME endoribonuclease L-psp HB366_01555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HB366_01570 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HB366_01620 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HB366_01635 ENOG4107IFA Lipase (EC 3.1.1.3) HB366_01640 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HB366_01645 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HB366_01670 ENOG4108JQ1 Dehydrogenase HB366_01675 ENOG4105CQB FAD linked oxidase domain protein HB366_01685 ENOG4105VRH Antibiotic biosynthesis monooxygenase HB366_01690 ENOG4105NF4 modulator of drug activity HB366_01700 ENOG4107QF7 multi-drug HB366_01705 ENOG4105EM2 membrane HB366_01710 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HB366_01715 ENOG4105IPI Membrane HB366_01720 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HB366_01750 ENOG4108IQI permease HB366_01755 ENOG4105D82 Glutamate dehydrogenase HB366_01760 ENOG4105C8Y Acetylornithine aminotransferase HB366_01770 ENOG4105C26 Dehydrogenase HB366_01855 ENOG4105W87 Cbs domain HB366_01860 ENOG41067S9 phage shock protein C, PspC HB366_01870 ENOG4105CSU acyl-Coa dehydrogenase HB366_01885 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HB366_01900 ENOG4105ECY inositol monophosphatase HB366_01905 ENOG4105C1J atp-dependent rna helicase HB366_01915 ENOG4105DHJ ABC, transporter HB366_01920 ENOG4105CY3 ABC transporter, permease HB366_01930 ENOG4105E3I toluene tolerance HB366_01940 ENOG4105D7N magnesium and cobalt transport protein CorA HB366_01945 ENOG4108URH decarboxylase HB366_01955 ENOG4105MJ2 Competence protein HB366_01960 ENOG4105CB5 ATP-dependent DNA helicase recG HB366_01980 ENOG4105C29 acyl-CoA thioesterase HB366_01985 ENOG4105CK2 sodium dicarboxylate symporter HB366_02000 ENOG4105KPV Transcriptional regulator HB366_02010 ENOG4105D7A ATP-binding protein HB366_02020 ENOG41089BK Glutamine amido-transferase HB366_02130 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HB366_02170 ENOG4105C1G acyl-Coa dehydrogenase HB366_02205 ENOG4105VKU nucleicacid-binding protein HB366_02210 ENOG4105DGW oligopeptidase A HB366_02215 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HB366_02260 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HB366_02265 ENOG4108K2B transcriptional regulator HB366_02275 ENOG4107S2Z UPF0761 membrane protein HB366_02280 ENOG4105CS1 NAD(P)H quinone oxidoreductase HB366_02310 ENOG4105C9A Phoh family HB366_02320 ENOG4105E4C Lytic transglycosylase catalytic HB366_02350 ENOG4105D6S protein involved in catabolism of external DNA HB366_02355 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HB366_02400 ENOG4105C1G acyl-Coa dehydrogenase HB366_02405 ENOG4108RZE Tetr family transcriptional regulator HB366_02420 ENOG4107QX3 carboxylase HB366_02425 ENOG4105C1G acyl-Coa dehydrogenase HB366_02445 ENOG4105KB2 stringent starvation protein b HB366_02450 ENOG4107MKT Stringent starvation protein a HB366_02455 ENOG4108UJD 30S ribosomal protein S9 HB366_02465 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HB366_02470 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HB366_02475 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HB366_02495 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HB366_02505 ENOG4107RZC phospholipase d HB366_02515 ENOG4105UYK outer membrane protein a HB366_02520 ENOG4108KHX Diguanylate cyclase HB366_02555 ENOG4107QN2 dihydrolipoyl dehydrogenase HB366_02570 ENOG4107U2T alpha beta HB366_02580 ENOG4105NAU thioesterase Superfamily protein HB366_02610 ENOG4105K9H YciI-like protein HB366_02620 ENOG4105DB7 PHP domain protein HB366_02625 ENOG4105FFC UPF0187 protein HB366_02635 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HB366_02640 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HB366_02645 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HB366_02650 ENOG4105VIE preprotein translocase, subunit YajC HB366_02680 ENOG4105BZU Histidine kinase HB366_02685 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HB366_02690 ENOG4105CM2 brancheD-chain amino acid aminotransferase HB366_02705 ENOG4107BJW polysaccharide deacetylase HB366_02715 ENOG4108PQP glycosyl transferase group 1 HB366_02755 ENOG4105UGU tonB-dependent Receptor HB366_02775 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HB366_02780 ENOG4108K3A Glutathione S-transferase HB366_02785 ENOG4108R4R Iron-regulated virulence regulatory protein HB366_02790 ENOG4105CSU acyl-Coa dehydrogenase HB366_02795 ENOG4105CSU acyl-Coa dehydrogenase HB366_02805 ENOG4105EB3 Histidine kinase HB366_02810 ENOG4105E3W Two component transcriptional regulator (Winged helix family HB366_02815 ENOG4105CNG UPF0061 protein HB366_02835 ENOG4108WBT adenosyltransferase HB366_02885 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HB366_02905 ENOG4105D3R alkyl hydroperoxide reductase HB366_02920 ENOG4105CSH Transporter HB366_02925 ENOG4108UT2 hemolysin iii HB366_02960 ENOG4105CHU acetyl-coa acetyltransferase HB366_02965 ENOG4108R6W Transcriptional regulator, ARAC family HB366_02975 ENOG4105TW1 Carbohydrate-selective porin OprB HB366_02980 ENOG4105DZG Dehydrogenase HB366_02985 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HB366_03005 ENOG4105CHU acetyl-coa acetyltransferase HB366_03015 ENOG4108WHA ompa motb domain protein HB366_03025 ENOG4105E0Y RtcB Protein HB366_03030 ENOG4108IQI permease HB366_03040 ENOG4105C2W permease HB366_03045 ENOG4105CI3 gtp-binding protein typa HB366_03060 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HB366_03070 ENOG4108VX5 3-methyladenine DNA glycosylase HB366_03075 ENOG4105CHB tonB-dependent Receptor HB366_03090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB366_03095 ENOG4108N2Y auxin Efflux HB366_03105 ENOG4105T95 Thiol disulfide interChange protein HB366_03110 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HB366_03120 ENOG4105K78 MarR family Transcriptional regulator HB366_03125 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HB366_03130 ENOG4105KWI UPF0339 protein HB366_03155 ENOG4108UNF response regulator HB366_03160 ENOG4105M3Z response regulator HB366_03165 ENOG4108ZGA chew protein HB366_03170 ENOG4105C8Q Methyl-accepting chemotaxis HB366_03175 ENOG4105CBS Chea signal transduction histidine kinase HB366_03190 ENOG4107PEH Entericidin EcnA/B family HB366_03200 ENOG4105WD1 Membrane HB366_03205 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HB366_03255 ENOG4105EM2 membrane HB366_03260 ENOG4105C2C drug resistance transporter, Bcr CflA HB366_03280 ENOG4105BZG amino acid carrier protein HB366_03285 ENOG4105D78 K07001 NTE family protein HB366_03290 ENOG4105C7B Threonine dehydratase HB366_03335 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HB366_03345 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HB366_03355 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HB366_03360 ENOG4105VQ7 Rod shape-determining protein MreD HB366_03365 ENOG4108Z03 MAF-like protein HB366_03370 ENOG4105C03 ribonuclease HB366_03380 ENOG4105D8T Acyltransferase HB366_03390 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HB366_03400 ENOG4108X0B nad(p)h dehydrogenase (quinone) HB366_03425 ENOG4105CF7 AraC family transcriptional regulator HB366_03445 ENOG4105C85 amino acid HB366_03450 ENOG4105C7F AcnD-accessory protein PrpF HB366_03455 ENOG4105CTB Polyprenyl synthetase HB366_03460 ENOG4105MSB protein, conserved in bacteria HB366_03475 ENOG4105D78 K07001 NTE family protein HB366_03495 ENOG4105DIJ Phosphoethanolamine transferase HB366_03500 ENOG4105XJC Two component transcriptional regulator (Winged helix family HB366_03505 ENOG4105DHQ Histidine kinase HB366_03520 ENOG4108M0I Transcriptional regulator HB366_03540 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HB366_03560 ENOG4105K8R UPF0145 protein HB366_03565 ENOG4105K8R UPF0145 protein HB366_03570 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HB366_03575 ENOG4105BZS acriflavin resistance protein HB366_03580 ENOG4105C1P efflux transporter, rnd family, mfp subunit HB366_03585 ENOG410841Q phosphoesterase PA-phosphatase related protein HB366_03615 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HB366_03630 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HB366_03635 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HB366_03640 ENOG4105KVH Transcriptional regulator HB366_03650 ENOG4105CUB amino acid HB366_03665 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HB366_03670 ENOG41084BA UPF0250 protein HB366_03675 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB366_03710 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HB366_03715 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HB366_03725 ENOG4105E33 succinate dehydrogenase HB366_03740 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HB366_03745 ENOG4105C7S Dehydrogenase HB366_03750 ENOG4107QN2 dihydrolipoyl dehydrogenase HB366_03760 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HB366_03770 ENOG4105CKW Inner membrane protein yedI HB366_03775 ENOG4105CGZ zinc metallopeptidase HB366_03780 ENOG4105EEQ Na H antiporter HB366_03815 ENOG4105PNM synthesis protein HB366_03830 ENOG41080TK Universal stress protein HB366_03845 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HB366_03850 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HB366_03865 ENOG4105HBR Rna-binding protein HB366_03875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HB366_03880 ENOG4105EEI dihydropteroate synthase HB366_03930 ENOG4105CSH Transporter HB366_03935 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HB366_03940 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HB366_03955 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HB366_03975 ENOG41080IJ Diacylglycerol kinase HB366_03985 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HB366_03990 ENOG4105BZS acriflavin resistance protein HB366_04005 ENOG4105E4C Lytic transglycosylase catalytic HB366_04025 ENOG4108RRZ Transcription elongation factor GreB HB366_04040 ENOG4105CEY Amp-dependent synthetase and ligase HB366_04080 ENOG4105BZW Glycerate kinase HB366_04085 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HB366_04090 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HB366_04105 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HB366_04115 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HB366_04120 ENOG4105C85 amino acid HB366_04130 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HB366_04140 ENOG4105N14 lysine exporter protein LysE YggA HB366_04145 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HB366_04150 ENOG4105BZJ Electron transfer flavoprotein HB366_04155 ENOG4105C10 Electron transfer flavoprotein HB366_04160 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB366_04195 ENOG4107KET secretion protein, HlyD family HB366_04230 ENOG4105D60 lipoprotein releasing system transmembrane protein HB366_04235 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HB366_04240 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HB366_04250 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HB366_04255 ENOG4107R6F Alpha Beta Hydrolase Fold protein HB366_04260 ENOG4108V3E phosphoribosylglycinamide formyltransferase HB366_04270 ENOG4105C02 permease HB366_04330 ENOG4105KCK Peptidoglycan-associated lipoprotein HB366_04335 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HB366_04345 ENOG4105M8F Biopolymer transport protein exbD tolR HB366_04350 ENOG4105E02 MotA TolQ exbB proton channel HB366_04355 ENOG4107YD3 Thioesterase HB366_04360 ENOG4105CH2 amidohydrolase HB366_04380 ENOG4108ETH Formylglycinamide ribotide synthetase HB366_04385 ENOG4105C2C drug resistance transporter, Bcr CflA HB366_04395 ENOG4108UKI Enoyl-CoA hydratase HB366_04410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HB366_04425 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HB366_04430 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HB366_04445 ENOG4107R11 Transcriptional regulator HB366_04450 ENOG4108IJ6 ABC transporter HB366_04460 ENOG4108I5D sulfate abc transporter HB366_04470 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HB366_04475 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HB366_04480 ENOG4105HHA aminodeoxychorismate lyase HB366_04495 ENOG4108IYU L-aspartate oxidase HB366_04500 ENOG4105C0H protease HB366_04515 ENOG4105C3F Signal peptidase i HB366_04530 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HB366_04540 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HB366_04545 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HB366_04550 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HB366_04555 ENOG4105EMU Dehydrogenase HB366_04595 ENOG4105BZU Histidine kinase HB366_04605 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HB366_04615 ENOG4105DTR rard protein HB366_04650 ENOG4107QS8 (LipO)protein HB366_04655 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HB366_04660 ENOG4105EA8 2-Nitropropane dioxygenase HB366_04690 ENOG4107R8N Glycosyl transferase, family 2 HB366_04705 ENOG4105CVP deoxyribo-dipyrimidine photolyase HB366_04710 ENOG4108YZY peptidylprolyl cis-trans isomerase HB366_04715 ENOG4105CEP NADH dehydrogenase HB366_04720 ENOG4105DZ1 carboxypeptidase HB366_04730 ENOG4105E9K Isocitrate dehydrogenase HB366_04735 ENOG4108R99 pseudouridine synthase HB366_04760 ENOG4105CBP Major Facilitator HB366_04765 ENOG4105EGI Transcriptional regulator HB366_04770 ENOG4108ETY sodium dicarboxylate symporter HB366_04775 ENOG4105JAB phenazine biosynthesis protein, phzf family HB366_04805 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HB366_04820 ENOG4105D3G Pseudouridine synthase HB366_04825 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HB366_04840 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HB366_04865 ENOG4108JPW Aminotransferase HB366_04870 ENOG4105DY8 decarboxylase HB366_04880 ENOG4105F7P transcriptional regulator AsnC family HB366_04885 ENOG4107RA9 decarboxylase HB366_04890 ENOG4105C85 amino acid HB366_04895 ENOG4105CVA phosphate HB366_04900 ENOG4105C8U phosphate abc transporter HB366_04910 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HB366_04915 ENOG4105ERU peptidase HB366_04925 ENOG4105D5G Transposase HB366_04935 ENOG4107QTF adenylosuccinate lyase HB366_04955 ENOG4108Z0R Transferase HB366_04960 ENOG4105DZ1 carboxypeptidase HB366_04980 ENOG4108K5P (LipO)protein HB366_04985 ENOG4105EJC lysr family transcriptional regulator HB366_04990 ENOG4105DAN ATP-dependent protease HB366_05005 ENOG4105DHU Bile acid HB366_05025 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HB366_05035 ENOG4105D22 carbon starvation protein HB366_05040 ENOG4105VCD cytoplasmic protein HB366_05075 ENOG4108K8K Transcriptional regulator HB366_05090 ENOG4105C26 Dehydrogenase HB366_05095 ENOG4105C85 amino acid HB366_05100 ENOG4105ETT transcriptional Regulator, LysR family HB366_05105 ENOG4105C94 Transporter HB366_05110 ENOG4105C94 Transporter HB366_05125 ENOG4107QZF nitrite reductase NADPH large subunit HB366_05130 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HB366_05160 ENOG41060M8 Pfam:PhdYeFM HB366_05165 ENOG4107QNK )-transporter HB366_05170 ENOG4107WEA mandelate racemase muconate lactonizing HB366_05180 ENOG4105J7D transcriptional regulator HB366_05200 ENOG4105C2I pirin domain protein HB366_05210 ENOG4105WWK YheO domain protein HB366_05225 ENOG4105CEY Amp-dependent synthetase and ligase HB366_05240 ENOG4108IPW abc transporter atp-binding protein HB366_05260 ENOG4105C0W non-ribosomal peptide synthetase HB366_05265 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HB366_05270 ENOG4105WQI isochorismatase HB366_05285 ENOG4105BZ1 (ABC) transporter HB366_05305 ENOG4105E4F Isochorismate synthase HB366_05355 ENOG4105EUJ GTP cyclohydrolase i HB366_05365 ENOG4105C7W Xanthine dehydrogenase HB366_05395 ENOG4105CD8 aminopeptidase N HB366_05400 ENOG4105DDQ anthranilate synthase HB366_05410 ENOG4105DUX Transporter HB366_05425 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HB366_05460 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HB366_05465 ENOG4107QNR UPF0135 protein HB366_05470 ENOG4105C0H protease HB366_05480 ENOG4105C6K Malic enzyme HB366_05485 ENOG4105BZU Histidine kinase HB366_05490 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HB366_05495 ENOG4105SYT Methylenetetrahydrofolate reductase HB366_05500 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HB366_05515 ENOG4107QPN acyl-Coa dehydrogenase HB366_05520 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HB366_05525 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HB366_05535 ENOG4107RNU major facilitator superfamily MFS_1 HB366_05545 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HB366_05550 ENOG4105CE9 30S ribosomal protein S2 HB366_05590 ENOG4105CVE Lytic murein transglycosylase HB366_05595 ENOG4105CNI cell division protein FtsW HB366_05620 ENOG4105E3A (ABC) transporter HB366_05625 ENOG4105DA5 (ABC) transporter HB366_05660 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HB366_05670 ENOG4105ENT Efflux transporter rnd family, mfp subunit HB366_05680 ENOG4105E89 ABC transporter HB366_05685 ENOG4105DSP amino acid AbC transporter HB366_05690 ENOG4106YG3 ABC transporter HB366_05695 ENOG4108JEH abc transporter atp-binding protein HB366_05705 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HB366_05710 ENOG4105CFP Peptidase U32 HB366_05715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HB366_05720 ENOG4105JAB phenazine biosynthesis protein, phzf family HB366_05725 ENOG4105DP0 ferredoxin-NADP reductase HB366_05730 ENOG4108R96 Methyltransferase, YaeB family HB366_05740 ENOG4107QHF type ii secretion system protein e HB366_05750 ENOG4105XJC Two component transcriptional regulator (Winged helix family HB366_05755 ENOG4105DHQ Histidine kinase HB366_05765 ENOG4105M6F mutator MutT protein HB366_05775 ENOG4105BZ4 penicillin-binding protein HB366_05780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HB366_05785 ENOG4105VUT cytoplasmic protein HB366_05790 ENOG4107QYG anthranilate phosphoribosyltransferase HB366_05795 ENOG4105CK2 sodium dicarboxylate symporter HB366_05800 ENOG4105C1G acyl-Coa dehydrogenase HB366_05805 ENOG4105NIV Esterase HB366_05810 ENOG4105CQC Prephenate dehydratase HB366_05815 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HB366_05825 ENOG4105CIN aminoacyl-histidine dipeptidase HB366_05830 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HB366_05860 ENOG4105M08 Membrane HB366_05865 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HB366_05875 ENOG4105VEQ Cold shock protein HB366_05880 ENOG4105C1J atp-dependent rna helicase HB366_05890 ENOG41069NU Nitroreductase HB366_05925 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HB366_05940 ENOG4105C5I Dehydrogenase HB366_05945 ENOG4105ERG peptidase m48, ste24p HB366_05950 ENOG4105KTH gatB Yqey HB366_05980 ENOG4105D9P serine threonine protein kinase HB366_06005 ENOG4105EVZ LysR family transcriptional regulator HB366_06010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HB366_06015 ENOG4105C26 Dehydrogenase HB366_06050 ENOG4105H4F exported protein HB366_06080 ENOG4105D6U Sodium Glutamate Symporter HB366_06090 ENOG4105JXH GntR family transcriptional regulator HB366_06140 ENOG4105CSH Transporter HB366_06160 ENOG4105CEB Aspartate aminotransferase HB366_06175 ENOG4105F1S paraquat-inducible protein a HB366_06180 ENOG4105DY2 Paraquat-inducible protein b HB366_06200 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HB366_06225 ENOG4108BUD transposase HB366_06240 ENOG4105CK2 sodium dicarboxylate symporter HB366_06250 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HB366_06255 ENOG4108UMI ABC transporter, permease HB366_06260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HB366_06270 ENOG4105C12 Phosphoribosylglycinamide synthetase HB366_06275 ENOG4105DC1 bifunctional purine biosynthesis protein purh HB366_06280 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HB366_06330 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HB366_06335 ENOG4105CDU Replicative dna helicase HB366_06360 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HB366_06365 ENOG4105CCU oxidase (Subunit III) HB366_06370 ENOG4105BZ9 Cytochrome C oxidase, subunit I HB366_06375 ENOG4105E2S oxidase) subunit II HB366_06400 ENOG4107BJW polysaccharide deacetylase HB366_06405 ENOG4105CND Glycosyl transferase, family 2 HB366_06420 ENOG4105DEN Luciferase family HB366_06435 ENOG4105CC0 LysR family Transcriptional regulator HB366_06450 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HB366_06455 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HB366_06460 ENOG4105GVF (ABC) transporter HB366_06475 ENOG4105C1G acyl-Coa dehydrogenase HB366_06485 ENOG4108MEJ flavin reductase domain protein HB366_06490 ENOG4105D06 uba thif-type nad fad binding protein HB366_06510 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HB366_06515 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HB366_06525 ENOG4105C08 Histidine kinase HB366_06530 ENOG4105EEX Two component transcriptional regulator (Winged helix family HB366_06535 ENOG4105CFQ glutamine synthetase HB366_06550 ENOG4107S74 Lysophospholipid transporter LplT HB366_06555 ENOG4105CFU surface antigen HB366_06570 ENOG4107QIJ Aconitate hydratase 2 HB366_06580 ENOG4105EYW Ion transport protein HB366_06585 ENOG4105F27 Major Facilitator HB366_06600 ENOG4105DZ2 Transcriptional regulator HB366_06635 ENOG4105K8N protein family UPF0079, ATPase HB366_06640 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HB366_06650 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HB366_06655 ENOG4108TZV Membrane HB366_06660 ENOG4108RCM Nitroreductase HB366_06670 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HB366_06680 ENOG4105CX6 glutaminyL-tRNA synthetase HB366_06685 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HB366_06690 ENOG4107FQ9 ethanolamine ammonia-lyase HB366_06695 ENOG4105CPD ethanolamine ammonia-lyase HB366_06700 ENOG4107R55 ethanolamine transporter HB366_06710 ENOG4107RR1 TRANSCRIPTIONal HB366_06720 ENOG4105C0A alcohol dehydrogenase HB366_06725 ENOG4107QUV Domain protein HB366_06735 ENOG4105F4I Transcriptional regulator HB366_06755 ENOG4105CD8 aminopeptidase N HB366_06785 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HB366_06790 ENOG4105EW9 transcriptional regulator AsnC family HB366_06800 ENOG4105R8C Transcriptional regulator HB366_06810 ENOG4105CUY Mechanosensitive ion channel HB366_06845 ENOG4105CNM Receptor HB366_06865 ENOG4105C5H ABC transporter HB366_06870 ENOG41081QV Universal stress protein HB366_06895 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HB366_06905 ENOG4105DKK Benzoate HB366_06910 ENOG4105EW9 transcriptional regulator AsnC family HB366_06915 ENOG4108NIW Leucine export protein LeuE HB366_06925 ENOG4105C5Q Transcriptional regulator HB366_06935 ENOG4105CHU acetyl-coa acetyltransferase HB366_06940 ENOG4105CHR reductase HB366_06965 ENOG4107QMP dna polymerase iii subunits gamma and tau HB366_06970 ENOG4105HSS phospholipase C HB366_06980 ENOG4105C0A alcohol dehydrogenase HB366_07010 ENOG4105CBC glutamate synthase HB366_07295 ENOG4105DR5 peptidase HB366_07360 ENOG4105D8G Major Facilitator superfamily HB366_07370 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HB366_07375 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HB366_07400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB366_07410 ENOG4107QZF nitrite reductase NADPH large subunit HB366_07415 ENOG4108IFG nitrite reductase, (NAD(P)H) HB366_07430 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HB366_07435 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HB366_07450 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HB366_07455 ENOG4105CVM Molybdenum cofactor synthesis domain protein HB366_07465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HB366_07470 ENOG4105T38 integral membrane protein HB366_07490 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HB366_07495 ENOG4105CMR udp-glucose 4-epimerase HB366_07560 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HB366_07565 ENOG4105CUX Signal transduction histidine kinase HB366_07585 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HB366_07590 ENOG4105KNE Phosphatidate cytidylyltransferase HB366_07600 ENOG4105DZP Membrane-associated zinc metalloprotease HB366_07625 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HB366_07640 ENOG4105Y3E Modulates RecA activity (By similarity) HB366_07650 ENOG4105VEJ Heat shock protein HB366_07655 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HB366_07680 ENOG4105F7P transcriptional regulator AsnC family HB366_07690 ENOG4105C85 amino acid HB366_07705 ENOG4105CHH sulfate transporter HB366_07710 ENOG4108RAV Conserved protein HB366_07715 ENOG4105D8V Glucose sorbosone dehydrogenase HB366_07725 ENOG4105BZU Histidine kinase HB366_07745 ENOG4105DM4 PTS System HB366_07750 ENOG4105DE4 1-phosphofructokinase HB366_07755 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HB366_07780 ENOG4105CWM branched-chain amino acid transport system II carrier protein HB366_07785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HB366_07790 ENOG4105CC0 LysR family Transcriptional regulator HB366_07800 ENOG4105M2J Glutaredoxin HB366_07805 ENOG4105C8Y Acetylornithine aminotransferase HB366_07810 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HB366_07835 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HB366_07845 ENOG41068P6 UPF0319 protein HB366_07865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HB366_07870 ENOG4105C4M (Ubiquinol oxidase) subunit I HB366_07880 ENOG4105PV3 Inner membrane protein yqiJ HB366_07895 ENOG4105E0K tonB-dependent siderophore receptor HB366_07905 ENOG4105HDD phospholipase HB366_07910 ENOG4105CZN Potassium uptake protein HB366_07920 ENOG4105C7B Threonine dehydratase HB366_07950 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HB366_07955 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB366_07965 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HB366_07980 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB366_08025 ENOG4107VMU Membrane HB366_08030 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HB366_08040 ENOG4107QP7 CoA-transferase subunit A HB366_08045 ENOG4107QNJ CoA-transferase subunit B HB366_08050 ENOG4105CHU acetyl-coa acetyltransferase HB366_08055 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HB366_08060 ENOG4105F2Z 3-oxoadipate enol-lactonase HB366_08065 ENOG4105D2S major facilitator superfamily HB366_08070 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HB366_08075 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HB366_08080 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HB366_08085 ENOG4105FF2 Type I DHQase HB366_08090 ENOG4106JPM 3-dehydroshikimate dehydratase HB366_08095 ENOG4105TW1 Carbohydrate-selective porin OprB HB366_08100 ENOG4105DZG Dehydrogenase HB366_08110 ENOG4105MD1 YeeE YedE family protein HB366_08125 ENOG4107HP6 Transcriptional regulator HB366_08130 ENOG4108PTX LysR family Transcriptional regulator HB366_08135 ENOG4105C1G acyl-Coa dehydrogenase HB366_08160 ENOG4105DNH Major Facilitator HB366_08170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HB366_08190 ENOG4105FUY alpha subunit HB366_08200 ENOG4105CHR reductase HB366_08220 ENOG4105F11 amine oxidase HB366_08230 ENOG4105C26 Dehydrogenase HB366_08240 ENOG4105F2Z 3-oxoadipate enol-lactonase HB366_08245 ENOG4105CHU acetyl-coa acetyltransferase HB366_08250 ENOG4107QNJ CoA-transferase subunit B HB366_08255 ENOG4107QP7 CoA-transferase subunit A HB366_08265 ENOG4105NN7 muconolactone delta-isomerase HB366_08270 ENOG4105DTQ mandelate racemase muconate lactonizing HB366_08275 ENOG4108KB2 LysR family Transcriptional regulator HB366_08285 ENOG4107EJG GntR family transcriptional regulator HB366_08305 ENOG4105CZJ Aldehyde dehydrogenase HB366_08325 ENOG4105C1G acyl-Coa dehydrogenase HB366_08330 ENOG4105CHR reductase HB366_08335 ENOG4108JU7 Transcriptional regulator HB366_08345 ENOG41062QD Membrane HB366_08360 ENOG4107RGH Aldehyde dehydrogenase HB366_08375 ENOG4105CH6 catalase HB366_08395 ENOG4105K56 Transcriptional regulator HB366_08400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB366_08410 ENOG4105NAE bifunctional deaminase-reductase domain protein HB366_08440 ENOG4107Z3H Transcriptional regulator, TetR family HB366_08450 ENOG4105CHJ isochorismatase hydrolase HB366_08455 ENOG4105EJC lysr family transcriptional regulator HB366_08460 ENOG4105D8V Glucose sorbosone dehydrogenase HB366_08465 ENOG4105CKD glutathione-regulated potassium-efflux system protein HB366_08475 ENOG4105CH2 amidohydrolase HB366_08485 ENOG4105D5K Hemolysin activator protein HB366_08490 ENOG4105CKT filamentous hemagglutinin HB366_08535 ENOG4106P55 Transcriptional regulator HB366_08565 ENOG4105JSC dimethylmenaquinone methyltransferase HB366_08585 ENOG4105CW7 secretion protein, HlyD family HB366_08600 ENOG4105CZJ Aldehyde dehydrogenase HB366_08615 ENOG4105DDW LysR family Transcriptional regulator HB366_08620 ENOG4105EXW epimerase dehydratase HB366_08630 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HB366_08635 ENOG4105CF7 AraC family transcriptional regulator HB366_08650 ENOG4105DQ4 alcohol dehydrogenase HB366_08660 ENOG4105EHG Permease protein HB366_08665 ENOG4105E0A ABC, transporter HB366_08685 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HB366_08760 ENOG4108UAJ Transcriptional regulator HB366_08800 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HB366_08850 ENOG4108BAS reductase HB366_08865 ENOG4108R6W Transcriptional regulator, ARAC family HB366_08870 ENOG4108821 RND type efflux pump HB366_08875 ENOG4105E0F Histidine kinase HB366_08880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HB366_08885 ENOG4105C1P efflux transporter, rnd family, mfp subunit HB366_08890 ENOG4105BZS acriflavin resistance protein HB366_08895 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HB366_08905 ENOG4105CT3 Monooxygenase HB366_08925 ENOG4105CJP fad dependent oxidoreductase HB366_08945 ENOG4105X0I Fimbrial HB366_09000 ENOG4107RZC phospholipase d HB366_09020 ENOG4108IGT Dipeptidase HB366_09055 ENOG4107T31 5'-nucleotidase HB366_09065 ENOG4105WQI isochorismatase HB366_09070 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HB366_09075 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HB366_09080 ENOG4105E0C molybdate abc transporter HB366_09085 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HB366_09090 ENOG4105F4R Transcriptional regulator mode HB366_09095 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HB366_09100 ENOG4108YS2 small subunit HB366_09105 ENOG4105F57 Anthranilate dioxygenase reductase HB366_09130 ENOG4105CHR reductase HB366_09145 ENOG4105CF7 AraC family transcriptional regulator HB366_09155 ENOG4105DTD Dehydrogenase HB366_09160 ENOG4105CY2 Citrate transporter HB366_09170 ENOG4108M0I Transcriptional regulator HB366_09180 ENOG4107QNJ CoA-transferase subunit B HB366_09185 ENOG4105CRW Short chain fatty acid transporter HB366_09190 ENOG4105CHU acetyl-coa acetyltransferase HB366_09200 ENOG4107YNJ LysR family Transcriptional regulator HB366_09215 ENOG4108IJ0 Aspartate ammonia-lyase HB366_09225 ENOG4105CSH Transporter HB366_09245 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HB366_09250 ENOG4106FTQ Taurine ABC transporter, periplasmic HB366_09275 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HB366_09280 ENOG4105KVH Transcriptional regulator HB366_09285 ENOG4105UEI Transcriptional Regulator AraC Family HB366_09300 ENOG4108VCT Sulfite exporter TauE/SafE HB366_09310 ENOG4107QPB Beta-lactamase domain protein HB366_09320 ENOG4105FFC UPF0187 protein HB366_09330 ENOG4105CHR reductase HB366_09345 ENOG4105CPP Dehydrogenase, E1 component HB366_09350 ENOG4107R0V Pyruvate dehydrogenase HB366_09355 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HB366_09370 ENOG4105BZU Histidine kinase HB366_09380 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HB366_09385 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HB366_09430 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HB366_09445 ENOG4105C28 cystathionine HB366_09455 ENOG4105F2W methyltransferase HB366_09485 ENOG4105K59 histidine triad (HIT) protein HB366_09510 ENOG4107QWP ABC-2 type transporter HB366_09515 ENOG4107QWP ABC-2 type transporter HB366_09520 ENOG4105CJ1 ABC, transporter HB366_09535 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HB366_09540 ENOG4105CNM Receptor HB366_09560 ENOG4107TSN permease HB366_09565 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HB366_09585 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HB366_09590 ENOG4108YZT Adenosylcobinamide kinase HB366_09640 ENOG4105DJU Siderophore biosynthesis protein HB366_09645 ENOG4105DUU IucA IucC family protein HB366_09665 ENOG4108Z66 YbaK ebsC protein HB366_09680 ENOG4105C1G acyl-Coa dehydrogenase HB366_09685 ENOG4105C1G acyl-Coa dehydrogenase HB366_09690 ENOG4105EEF Alkane 1-monooxygenase HB366_09695 ENOG4105E7U AraC family transcriptional regulator HB366_09700 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HB366_09705 ENOG4105K70 DNA-binding protein HB366_09720 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HB366_09730 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HB366_09735 ENOG4108Z4V iron-sulfur cluster assembly HB366_09750 ENOG4108ZIT Ferredoxin, 2FE-2S HB366_09755 ENOG4105F8J Adenylate Guanylate cyclase HB366_09765 ENOG4108JA2 transcriptioN-repair coupling factor HB366_09785 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HB366_09790 ENOG4105K4T epimerase HB366_09805 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HB366_09825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HB366_09835 ENOG4105DGW oligopeptidase A HB366_09875 ENOG4105SG9 biopolymer transport protein, ExbD HB366_09885 ENOG4107QP3 malate synthase g HB366_09890 ENOG4105D6Z AFG1 family ATPase HB366_09900 ENOG4107RN6 Monooxygenase HB366_09920 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HB366_09925 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HB366_09940 ENOG4108Z6B deaminase HB366_09960 ENOG4108RTD type II secretion system protein K HB366_09985 ENOG4105F8V Hydrolase, tatD family HB366_09995 ENOG4107QRG dna polymerase iii HB366_10005 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HB366_10010 ENOG4105BZ1 (ABC) transporter HB366_10025 ENOG4105FA0 parb-like partition protein HB366_10030 ENOG4107QJE Chromosome Partitioning Protein HB366_10040 ENOG4108S0S Nucleotidyl transferase HB366_10045 ENOG4105EHM Aminoglycoside phosphotransferase HB366_10050 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HB366_10055 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HB366_10060 ENOG4105D2N Aldolase HB366_10080 ENOG4108UHJ MAF-like protein HB366_10085 ENOG4105EZE Cupin 4 family protein HB366_10095 ENOG41080HT Transcriptional regulator, arsr family HB366_10110 ENOG4105XPP Protein of unknown function (DUF1275) HB366_10115 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HB366_10120 ENOG4105BZ1 (ABC) transporter HB366_10130 ENOG4108ZX5 transcriptional regulator HB366_10140 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HB366_10145 ENOG4105CK7 Sodium proline symporter HB366_10150 ENOG4105EW9 transcriptional regulator AsnC family HB366_10155 ENOG4105C26 Dehydrogenase HB366_10160 ENOG4105YGK Pfam:UPF0157 HB366_10175 ENOG4108T58 Mg2 transport protein CorA HB366_10185 ENOG4108YYC ycei family HB366_10195 ENOG4105CV1 Transketolase (EC 2.2.1.1) HB366_10220 ENOG4108HWY Beta-lactamase HB366_10240 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HB366_10245 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HB366_10265 ENOG4105X0I Fimbrial HB366_10270 ENOG4105GQR Chaperone HB366_10295 ENOG4108IPJ Membrane HB366_10305 ENOG4105ETS cytosine purines uracil thiamine allantoin HB366_10315 ENOG4105CC0 LysR family Transcriptional regulator HB366_10335 ENOG41067SE Tetr family transcriptional regulator HB366_10350 ENOG4105EW9 transcriptional regulator AsnC family HB366_10360 ENOG4105CDA abc transporter atp-binding protein HB366_10365 ENOG4105DRP amino acid AbC transporter HB366_10370 ENOG4105EAD ABC transporter HB366_10385 ENOG4107T8P acyl-Coa dehydrogenase HB366_10400 ENOG4105D01 (LipO)protein HB366_10405 ENOG4105D01 (LipO)protein HB366_10410 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HB366_10415 ENOG4108UMI ABC transporter, permease HB366_10420 ENOG4105C3G gtp-binding protein HB366_10445 ENOG4108UMN azlc family HB366_10450 ENOG4105ZED uncharacterized protein ygaH HB366_10480 ENOG4105E7U AraC family transcriptional regulator HB366_10485 ENOG4108V06 Glutathione peroxidase HB366_10495 ENOG4105CHM Aminotransferase HB366_10510 ENOG4105C0B DNA polymerase III (alpha subunit) HB366_10535 ENOG4108JU3 Alkyl hydroperoxide reductase HB366_10550 ENOG4108KB2 LysR family Transcriptional regulator HB366_10555 ENOG4105D6J arsenicaL-resistance protein HB366_10560 ENOG41082YX Transcriptional regulator, arsr family HB366_10575 ENOG4105CPN adenine deaminase HB366_10585 ENOG4105CBN LysR family transcriptional regulator HB366_10595 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HB366_10610 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HB366_10615 ENOG4108IY8 ABC, transporter HB366_10620 ENOG4106FTQ Taurine ABC transporter, periplasmic HB366_10630 ENOG4105C54 Major Facilitator superfamily HB366_10650 ENOG4105C4M (Ubiquinol oxidase) subunit I HB366_10655 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HB366_10665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HB366_10670 ENOG4108K70 Transcriptional regulator HB366_10685 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HB366_10690 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HB366_10705 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HB366_10710 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HB366_10720 ENOG4105DXI Major Facilitator superfamily HB366_10740 ENOG41067MG lrgb family HB366_10745 ENOG4105VAW lrga family HB366_10750 ENOG4105CMU LysR family (Transcriptional regulator HB366_10755 ENOG4108SHQ Glutathione S-transferase HB366_10760 ENOG4105CYM Glutathione S-transferase HB366_10765 ENOG4105CBN LysR family transcriptional regulator HB366_10770 ENOG4105CHR reductase HB366_10780 ENOG4105D7W serine acetyltransferase HB366_10785 ENOG4105ESN nucleotide-binding protein HB366_10790 ENOG4105C9B Cysteine desulfurase HB366_10800 ENOG4105CCF Lysine exporter protein (Lyse ygga) HB366_10805 ENOG4105EXG Transcriptional regulator HB366_10815 ENOG4105CT1 (ABC) transporter HB366_10820 ENOG4107RP9 extracellular solute-binding protein, family 3 HB366_10825 ENOG4105CDA abc transporter atp-binding protein HB366_10830 ENOG4108HW4 amino acid AbC transporter HB366_10835 ENOG4105EAD ABC transporter HB366_10850 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HB366_10855 ENOG4105BZU Histidine kinase HB366_10865 ENOG4105EW9 transcriptional regulator AsnC family HB366_10875 ENOG4105KT5 UmuD protein HB366_10895 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HB366_10945 ENOG4105HEI LysR family (Transcriptional regulator HB366_10965 ENOG4105CEY Amp-dependent synthetase and ligase HB366_10970 ENOG4105R8C Transcriptional regulator HB366_10975 ENOG4105C1G acyl-Coa dehydrogenase HB366_10980 ENOG4107QX3 carboxylase HB366_10985 ENOG4105E39 Enoyl-CoA hydratase HB366_11000 ENOG4105CC0 LysR family Transcriptional regulator HB366_11015 ENOG4105CSU acyl-Coa dehydrogenase HB366_11035 ENOG4107QNJ CoA-transferase subunit B HB366_11040 ENOG4107QP7 CoA-transferase subunit A HB366_11045 ENOG4107RGD Major Facilitator superfamily HB366_11050 ENOG4105C1G acyl-Coa dehydrogenase HB366_11055 ENOG4105E39 Enoyl-CoA hydratase HB366_11060 ENOG4105CHR reductase HB366_11065 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB366_11070 ENOG4105CHU acetyl-coa acetyltransferase HB366_11080 ENOG4105EQ0 Major Facilitator superfamily HB366_11085 ENOG4105EA8 2-Nitropropane dioxygenase HB366_11090 ENOG4108UKI Enoyl-CoA hydratase HB366_11105 ENOG4105C1G acyl-Coa dehydrogenase HB366_11110 ENOG4107RGD Major Facilitator superfamily HB366_11115 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HB366_11120 ENOG4107STF Involved in phosphonate degradation (By similarity) HB366_11130 ENOG4107RCV ABC transporter, permease HB366_11135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HB366_11140 ENOG4105C4Y ABC transporter HB366_11150 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HB366_11155 ENOG4107HP6 Transcriptional regulator HB366_11165 ENOG4105HEI LysR family (Transcriptional regulator HB366_11170 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HB366_11175 ENOG4105C26 Dehydrogenase HB366_11185 ENOG4105ETS cytosine purines uracil thiamine allantoin HB366_11195 ENOG4105C26 Dehydrogenase HB366_11200 ENOG4108M8W Monooxygenase HB366_11205 ENOG4105MXW flavin reductase domain protein, FMN-binding HB366_11210 ENOG4108MXF Alpha Beta Hydrolase HB366_11230 ENOG4105CPW cytochrome b561 HB366_11235 ENOG4107VGR Catalase HB366_11270 ENOG4107YAU phenylacetic acid degradation protein HB366_11280 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HB366_11285 ENOG4105DZS Phenylacetate-CoA ligase HB366_11290 ENOG4105CHU acetyl-coa acetyltransferase HB366_11295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HB366_11300 ENOG4108UKI Enoyl-CoA hydratase HB366_11305 ENOG4105E39 Enoyl-CoA hydratase HB366_11310 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HB366_11315 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HB366_11320 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HB366_11325 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HB366_11330 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HB366_11335 ENOG4105DXM phenylacetic acid degradation protein HB366_11340 ENOG4105EJQ L-serine dehydratase HB366_11345 ENOG4107QTZ amino acid HB366_11350 ENOG4105CZJ Aldehyde dehydrogenase HB366_11375 ENOG4105MWK D-amino acid dehydrogenase, small subunit HB366_11395 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB366_11405 ENOG4108Z4X TRANSCRIPTIONal HB366_11420 ENOG4105WPN DNA integration recombination invertion protein HB366_11435 ENOG4105DJ2 Major Facilitator Superfamily HB366_11440 ENOG4107Y2X deaminase HB366_11450 ENOG4105EMY transcriptional regulator HB366_11480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB366_11560 ENOG4108HW3 (ABC) transporter HB366_11570 ENOG4105MRR Transcriptional regulator (By similarity) HB366_11590 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HB366_11595 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HB366_11610 ENOG4105E2A Dehydrogenase HB366_11620 ENOG4105R8C Transcriptional regulator HB366_11640 ENOG4107R4J Chloride channel HB366_11645 ENOG4108JIK carboxylase HB366_11665 ENOG4105C5A transporter HB366_11670 ENOG4108WAV Transcriptional regulator HB366_11685 ENOG4105CNA YD repeat protein HB366_11720 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HB366_11740 ENOG4105D2S major facilitator superfamily HB366_11750 ENOG4105D1S lipid A biosynthesis HB366_11755 ENOG4105BZU Histidine kinase HB366_11760 ENOG4107AQZ Membrane HB366_11780 ENOG4108Z4U Ferredoxin HB366_11820 ENOG4105DFG type I secretion outer membrane protein HB366_11830 ENOG4108IUZ ABC transporter HB366_11835 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HB366_11850 ENOG4105C2X Arabinose 5-phosphate isomerase HB366_11980 ENOG41090AG Bacteriophage protein HB366_12000 ENOG4107ZQ5 Phage-associated protein, HI1409 family HB366_12090 ENOG4105W7J DNA binding HB366_12095 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HB366_12195 ENOG4105II7 pyrroline-5-carboxylate reductase HB366_12205 ENOG4105VEQ Cold shock protein HB366_12210 ENOG410829K Lysine exporter protein (Lyse ygga) HB366_12245 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HB366_12295 ENOG4108KB2 LysR family Transcriptional regulator HB366_12300 ENOG4105FUY alpha subunit HB366_12305 ENOG4108UKV benzoate 1,2-dioxygenase HB366_12310 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HB366_12315 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase HB366_12320 ENOG4105DKK Benzoate HB366_12325 ENOG4105D2S major facilitator superfamily HB366_12340 ENOG4105CQ7 ATP-dependent helicase HB366_12345 ENOG4105D3R alkyl hydroperoxide reductase HB366_12355 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HB366_12365 ENOG4108JU3 Alkyl hydroperoxide reductase HB366_12375 ENOG4108K3A Glutathione S-transferase HB366_12385 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HB366_12390 ENOG4108TGY Glutathione S-transferase HB366_12400 ENOG4108ZG0 Ompa motb domain protein HB366_12405 ENOG4105CD3 dihydroorotase HB366_12435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HB366_12450 ENOG4108UKZ OsmC family HB366_12455 ENOG4107RYR Transcriptional regulator, Crp Fnr family HB366_12465 ENOG4105CPC Aldo Keto reductase HB366_12480 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HB366_12490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HB366_12500 ENOG4105CFH Aspartokinase HB366_12510 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HB366_12520 ENOG4105CPW cytochrome b561 HB366_12525 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HB366_12530 ENOG4105C7N Xanthine uracil vitamin C permease HB366_12540 ENOG4105F95 Monooxygenase HB366_12565 ENOG4108BUD transposase HB366_12580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HB366_12600 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HB366_12620 ENOG4108JQ5 ABC transporter HB366_12625 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HB366_12630 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HB366_12640 ENOG4105E9H Lytic Murein transglycosylase HB366_12640 ENOG4105E9H Lytic Murein transglycosylase HB366_12645 ENOG4107RZZ dna polymerase iii epsilon subunit HB366_12655 ENOG4105E09 nadh pyrophosphatase HB366_12665 ENOG4105W4M Transport-associated protein HB366_12675 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HB366_12685 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HB366_12690 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HB366_12710 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HB366_12715 ENOG4105D0A hydroxylase HB366_12720 ENOG4107RAQ aminopeptidase HB366_12755 ENOG4105DIJ Phosphoethanolamine transferase HB366_12800 ENOG4105DR5 peptidase HB366_13125 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HB366_13150 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HB366_13160 ENOG4105D82 Glutamate dehydrogenase HB366_13165 ENOG4108R3D Electron transport complex HB366_13170 ENOG4105CSM endonuclease III HB366_13195 ENOG4105CJN penicillin-binding protein HB366_13200 ENOG4106H78 methyltransferase HB366_13215 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HB366_13225 ENOG4105CQM Urea amidohydrolase subunit alpha HB366_13255 ENOG4107RET Isocitrate lyase HB366_13265 ENOG4105C37 (CBS) domain HB366_13270 ENOG4105D4T Citrate transporter HB366_13285 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HB366_13305 ENOG4108MRJ HB366_13325 ENOG4105VCQ rubredoxin HB366_13330 ENOG4107QZF nitrite reductase NADPH large subunit HB366_13340 ENOG4105C5Q Transcriptional regulator HB366_13360 ENOG4107U91 Rhomboid family HB366_13365 ENOG4105CV6 ABC transporter, permease HB366_13370 ENOG4108I0Y (ABC) transporter HB366_13375 ENOG4108UJV acyl-CoA thioesterase i HB366_13395 ENOG4107RNH Outer membrane receptor FepA HB366_13410 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HB366_13415 ENOG4105E6M Sulphatase-modifying factor protein HB366_13435 ENOG4105CJ3 phosphate transporter HB366_13440 ENOG4105C3R Methionine synthase HB366_13455 ENOG4105CSP Major Facilitator Superfamily HB366_13465 ENOG4108PZW LysR family Transcriptional regulator HB366_13475 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HB366_13480 ENOG4105EU0 Major facilitator Superfamily HB366_13485 ENOG4108R6W Transcriptional regulator, ARAC family HB366_13490 ENOG4105CSV Glutaminase HB366_13495 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HB366_13500 ENOG4105CSH Transporter HB366_13510 ENOG4105C7K acetolactate synthase HB366_13525 ENOG4105CHR reductase HB366_13530 ENOG4108MXF Alpha Beta Hydrolase HB366_13540 ENOG4105DJB Major Facilitator Superfamily HB366_13545 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HB366_13555 ENOG4105CHR reductase HB366_13575 ENOG41069M3 Transcriptional regulator HB366_13590 ENOG4106YT9 Enoyl-CoA hydratase HB366_13600 ENOG4105CND Glycosyl transferase, family 2 HB366_13605 ENOG4107BJW polysaccharide deacetylase HB366_13615 ENOG4108VWS Yaeq family HB366_13625 ENOG4105CKI cobalamin synthesis protein HB366_13635 ENOG4108S4H thioesterase Superfamily protein HB366_13645 ENOG4105C94 Transporter HB366_13650 ENOG4105C94 Transporter HB366_13655 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HB366_13680 ENOG4107QK5 Homocysteine s-methyltransferase HB366_13685 ENOG4105D5Q Arginine ornithine antiporter HB366_13710 ENOG4108YNN Heme oxygenase HB366_13740 ENOG4108SF5 RNA Polymerase HB366_13750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB366_13755 ENOG4105C54 Major Facilitator superfamily HB366_13775 ENOG4105F8V Hydrolase, tatD family HB366_13810 ENOG4108UUM single-stranded DNA-binding protein HB366_13865 ENOG4105DFP Integrase HB366_13960 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HB366_14000 ENOG4105K4U addiction module toxin, RelE StbE family HB366_14235 ENOG41083X2 DNA polymerase III, epsilon subunit HB366_14305 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HB366_14310 ENOG4105C0R drug resistance transporter emrb qaca subfamily HB366_14315 ENOG4105CW7 secretion protein, HlyD family HB366_14320 ENOG4108VUY thioesterase Superfamily protein HB366_14325 ENOG4105D52 delta-aminolevulinic acid dehydratase HB366_14330 ENOG4105MWK D-amino acid dehydrogenase, small subunit HB366_14335 ENOG4105ECP epimerase HB366_14355 ENOG4107RH8 nuclease SbcCD subunit D HB366_14360 ENOG4105EYH Exonuclease HB366_14365 ENOG4105DFA alanine racemase domain protein HB366_14370 ENOG4105CZX twitching motility protein HB366_14375 ENOG4105CZX twitching motility protein HB366_14380 ENOG41090R7 Ferric uptake HB366_14405 ENOG4105E7A Glutamine amidotransferase HB366_14420 ENOG4107QKV phosphomannomutase HB366_14430 ENOG4105C4R Atp-dependent dna helicase HB366_14435 ENOG4108ZG0 Ompa motb domain protein HB366_14440 ENOG4106HNH Acyl-transferase HB366_14455 ENOG4107QMS site-determining protein HB366_14480 ENOG4105CCF Lysine exporter protein (Lyse ygga) HB366_14485 ENOG4105CNU cell division protein FtsK HB366_14490 ENOG4105C3M thioredoxin reductase HB366_14495 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HB366_14505 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HB366_14550 ENOG4108YXA Membrane HB366_14555 ENOG4105EUB pirin domain protein HB366_14565 ENOG4105C4K Nad synthetase HB366_14580 ENOG4105E3J oxidoreductase HB366_14585 ENOG4105C26 Dehydrogenase HB366_14590 ENOG4105DVW rieske (2Fe-2S) HB366_14600 ENOG4105C94 Transporter HB366_14605 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HB366_14610 ENOG4105EJC lysr family transcriptional regulator HB366_14630 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HB366_14650 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HB366_14655 ENOG4105C34 Pseudouridine synthase HB366_14660 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HB366_14665 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HB366_14680 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HB366_14710 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HB366_14740 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HB366_14750 ENOG4105DWF phosphomethylpyrimidine kinase HB366_14755 ENOG4109066 lysm domain bon superfamily protein HB366_14765 ENOG4105CHR reductase HB366_14770 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HB366_14780 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HB366_14785 ENOG4108BPE -transporting atpase HB366_14790 ENOG4107RTD sua5 ycio yrdc ywlc family protein HB366_14795 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HB366_14800 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HB366_14805 ENOG4105FE9 pseudouridine synthase HB366_14815 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HB366_14820 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HB366_14830 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HB366_14835 ENOG4108K4C ec 3.1.3.12 HB366_14840 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HB366_14845 ENOG4106UW1 Major Facilitator superfamily HB366_14865 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HB366_14875 ENOG4105HF0 Membrane HB366_14890 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HB366_14900 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HB366_14950 ENOG4105D1F ATP-binding protein HB366_14960 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HB366_14990 ENOG4105K6H D-cysteine desulfhydrase HB366_14995 ENOG4105CBX hi0933 family HB366_15020 ENOG4105DP0 ferredoxin-NADP reductase HB366_15025 ENOG4105DUM transcriptional regulator, lysR family HB366_15045 ENOG4105C8S subunit m HB366_15050 ENOG4105D65 subunit l HB366_15060 ENOG4107UFS subunit j HB366_15075 ENOG4108IEH NADH dehydrogenase subunit g HB366_15080 ENOG4107QIZ NADH dehydrogenase HB366_15085 ENOG4105GKE subunit e HB366_15105 ENOG4105BZU Histidine kinase HB366_15115 ENOG4105E0F Histidine kinase HB366_15120 ENOG4107EXC regulatoR HB366_15130 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB366_15140 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HB366_15150 ENOG4105EB3 Histidine kinase HB366_15220 ENOG4105DZG Dehydrogenase HB366_15240 ENOG4105JAB phenazine biosynthesis protein, phzf family HB366_15260 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HB366_15275 ENOG4105ETT transcriptional Regulator, LysR family HB366_15295 ENOG4105CH2 amidohydrolase HB366_15305 ENOG4106P55 Transcriptional regulator HB366_15320 ENOG4106P55 Transcriptional regulator HB366_15325 ENOG4107EFR Flavocytochrome c HB366_15335 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HB366_15340 ENOG4107RGD Major Facilitator superfamily HB366_15345 ENOG4105C1G acyl-Coa dehydrogenase HB366_15350 ENOG4105ETT transcriptional Regulator, LysR family HB366_15385 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HB366_15390 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HB366_15395 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HB366_15410 ENOG4105VR0 copper resistance HB366_15415 ENOG4105E3B Multicopper oxidase HB366_15425 ENOG4108HCJ Hydrolase HB366_15430 ENOG4105DJV ribulose-phosphate 3-epimerase HB366_15455 ENOG41072GX Peptidase M22 Glycoprotease HB366_15460 ENOG4108Z0R Transferase HB366_15505 ENOG4105CRQ synthase (Component I) HB366_15515 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HB366_15520 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HB366_15525 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HB366_15595 ENOG4105K56 Transcriptional regulator HB366_15600 ENOG4108ZHJ Organic hydroperoxide resistance protein HB366_15605 ENOG4107QHF type ii secretion system protein e HB366_15635 ENOG4105C2M dna polymerase I HB366_15640 ENOG4108VIA integral membrane protein HB366_15645 ENOG4105II7 pyrroline-5-carboxylate reductase HB366_15650 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HB366_15660 ENOG4105C9X ppx gppa phosphatase HB366_15670 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HB366_15690 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HB366_15730 ENOG4105W39 Membrane HB366_15735 ENOG4105CYM Glutathione S-transferase HB366_15750 ENOG4105CEY Amp-dependent synthetase and ligase HB366_15755 ENOG4105N42 UPF0307 protein HB366_15760 ENOG41080Z8 PHOSPHOCARRIER protein HB366_15780 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HB366_15785 ENOG4105DJ0 Poly(A) Polymerase HB366_15790 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HB366_15795 ENOG4105DXN mazG family HB366_15805 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HB366_15820 ENOG4105C6T cysteine synthase HB366_15825 ENOG4105BZU Histidine kinase HB366_15830 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HB366_15835 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HB366_15840 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HB366_15855 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HB366_15860 ENOG4105W8H transhydrogenase (subunit alpha HB366_15865 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HB366_15870 ENOG4106UX7 integral membrane protein HB366_15885 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HB366_15895 ENOG4107RSM transcriptional regulator HB366_15905 ENOG4105CUZ uba thif-type nad fad binding protein HB366_15915 ENOG4107QM5 aconitate hydratase HB366_15920 ENOG4105F8V Hydrolase, tatD family HB366_15935 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HB366_15955 ENOG4105BZU Histidine kinase HB366_15965 ENOG4108ZP8 Acetolactate synthase small subunit HB366_15970 ENOG4105C7K acetolactate synthase HB366_15995 ENOG4105DJY efflux transporter, rnd family, mfp subunit HB366_16000 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HB366_16005 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HB366_16010 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HB366_16020 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HB366_16025 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HB366_16035 ENOG4105VW4 glutaredoxin 3 HB366_16055 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HB366_16060 ENOG4105C2D reductase HB366_16070 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HB366_16100 ENOG4105C84 Histidine ammonia-lyase HB366_16115 ENOG4105CEY Amp-dependent synthetase and ligase HB366_16130 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HB366_16150 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HB366_16170 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HB366_16190 ENOG4105WVQ Fe-S assembly protein IscX HB366_16205 ENOG4105CN1 protease HB366_16220 ENOG4106HB6 Alpha beta hydrolase HB366_16230 ENOG4105C26 Dehydrogenase HB366_16235 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HB366_16240 ENOG4105C6Z Gluconate HB366_16245 ENOG4108UHU Aldolase HB366_16250 ENOG4105C01 Dihydroxy-acid dehydratase HB366_16260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HB366_16265 ENOG4108DNC Involved in acetate metabolism (By similarity) HB366_16270 ENOG4107GFK fumarate HB366_16290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HB366_16310 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HB366_16320 ENOG4105DWV Homoserine O-trans-acetylase HB366_16420 ENOG4105CIY formyltetrahydrofolate deformylase HB366_16430 ENOG4107RGH Aldehyde dehydrogenase HB366_16445 ENOG4105CKD glutathione-regulated potassium-efflux system protein HB366_16465 ENOG4105VFU Rna-binding protein HB366_16470 ENOG4105C4R Atp-dependent dna helicase HB366_16485 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HB366_16495 ENOG4105KVH Transcriptional regulator HB366_16510 ENOG4105C5H ABC transporter HB366_16515 ENOG4105N14 lysine exporter protein LysE YggA HB366_16520 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HB366_16530 ENOG4105CK2 sodium dicarboxylate symporter HB366_16585 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HB366_16610 ENOG4105DUM transcriptional regulator, lysR family HB366_16635 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HB366_16650 ENOG4108W5M transcriptional regulator HB366_16665 ENOG4105D29 Helix-turn-helix type 11 domain protein HB366_16670 ENOG4107XGZ Hydrolase HB366_16675 ENOG4105EI2 Pseudouridine synthase HB366_16685 ENOG4105C03 ribonuclease HB366_16690 ENOG4105J5T Amp-dependent synthetase and ligase HB366_16705 ENOG4105CBN LysR family transcriptional regulator HB366_16710 ENOG4105EMU Dehydrogenase HB366_16715 ENOG4105CSA Coproporphyrinogen iii oxidase HB366_16725 ENOG4107QI1 Mate efflux family protein HB366_16735 ENOG4107T8P acyl-Coa dehydrogenase HB366_16780 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HB366_16785 ENOG4105C5X domain protein HB366_16800 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HB366_16810 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HB366_16815 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HB366_16820 ENOG4108JU5 Magnesium and cobalt efflux protein HB366_16825 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HB366_16830 ENOG4108Z7R Chaperone CsaA HB366_16840 ENOG4108VAU general secretion pathway protein G HB366_16845 ENOG4105D7Q type ii secretion system HB366_16850 ENOG4105C25 Primosomal protein n' HB366_16855 ENOG4105CKD glutathione-regulated potassium-efflux system protein HB366_16860 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HB366_16870 ENOG4105DVC DnaJ domain protein HB366_16875 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HB366_16880 ENOG4107QUT magnesium and cobalt transport protein CorA HB366_16900 ENOG4107QYX exodeoxyribonuclease v alpha HB366_16905 ENOG4107QKA exodeoxyribonuclease V beta HB366_16910 ENOG4105DSY exodeoxyribonuclease V, gamma HB366_16920 ENOG4105CSR polyphosphate kinase 2 HB366_16930 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HB366_16945 ENOG41061H0 Monooxygenase HB366_16950 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HB366_16965 ENOG4105D65 subunit l HB366_16970 ENOG4108ZE9 Monovalent cation H antiporter subunit C HB366_16975 ENOG4107R4Z monovalent cation h antiporter subunit d HB366_16980 ENOG4105SC1 monovalent cation H antiporter subunit E HB366_16985 ENOG4105W4C monovalent cation H antiporter subunit F HB366_16990 ENOG4105KJM monovalent cation h antiporter subunit g HB366_17005 ENOG4105CHV Transcription elongation factor NusA HB366_17030 ENOG4107EJC Preprotein translocase subunit SecG HB366_17040 ENOG4107QHF type ii secretion system protein e HB366_17055 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HB366_17065 ENOG4105C2N RNA methyltransferase TrmH family group 3 HB366_17080 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HB366_17090 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HB366_17120 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HB366_17125 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HB366_17190 ENOG4107ZXU DSBA oxidoreductase HB366_17205 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HB366_17220 ENOG4105D3Y Na H antiporter HB366_17225 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HB366_17275 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HB366_17280 ENOG4105PM1 preprotein translocase subunit SecE HB366_17320 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HB366_17325 ENOG4105TV9 FHA Domain-Containing protein HB366_17330 ENOG4105GVR general secretion pathway protein D HB366_17345 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HB366_17370 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HB366_17375 ENOG4108NEV two component transcriptional regulator, LytTR family HB366_17380 ENOG4108HRK Histidine kinase HB366_17395 ENOG4108UTW Plays a role in the regulation of phosphate uptake HB366_17400 ENOG4105DFG type I secretion outer membrane protein HB366_17405 ENOG4108RNG Permease of the drug metabolite transporter HB366_17430 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HB366_17440 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HB366_17445 ENOG4105CNI cell division protein FtsW HB366_17460 ENOG4105CE1 Ferrous iron transport protein b HB366_17470 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HB366_17475 ENOG4105T95 Thiol disulfide interChange protein HB366_17480 ENOG4105D6E homoserine dehydrogenase HB366_17490 ENOG41061WM D-Alanyl-D-Alanine HB366_17500 ENOG4107TUY Histidine kinase HB366_17505 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HB366_17510 ENOG4105CN1 protease HB366_17515 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HB366_17520 ENOG4108K5H permease YjgP YjgQ family protein HB366_17560 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HB366_17570 ENOG4105BZU Histidine kinase HB366_17585 ENOG4105C0P Mg chelatase subunit ChlI HB366_17595 ENOG4108R0M Aminoglycoside HB366_17650 ENOG4108HWY Beta-lactamase HB366_17660 ENOG4105F6A helicase HB366_17675 ENOG4105CHH sulfate transporter HB366_17725 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HB366_17770 ENOG4105F6A helicase HB366_17780 ENOG4108HWY Beta-lactamase HB366_17805 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HB366_17835 ENOG4105CHH sulfate transporter HB366_17870 ENOG4105C0P Mg chelatase subunit ChlI HB366_17885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HB366_17895 ENOG4105EPF Outer membrane porin HB366_17900 ENOG4105F0N pyrophosphate phospho-hydrolase HB366_17915 ENOG4105CEY Amp-dependent synthetase and ligase HB366_17920 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HB366_17925 ENOG41079KZ Major Facilitator Superfamily HB366_17930 ENOG4105EN6 Membrane HB366_17940 ENOG4105EE5 Membrane protein terC HB366_17945 ENOG4108URH decarboxylase HB366_17960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HB366_17975 ENOG4105CCT upf0313 protein HB366_17995 ENOG4105CS1 NAD(P)H quinone oxidoreductase HB366_18005 ENOG4105C6T cysteine synthase HB366_18040 ENOG4105Y7M Transcriptional regulator, TetR family HB366_18075 ENOG4105C79 DNA protecting protein DprA HB366_18090 ENOG4108IND Tetr family transcriptional regulator HB366_18095 ENOG4107RTG Major Facilitator superfamily HB366_18105 ENOG4108V06 Glutathione peroxidase HB366_18170 ENOG4105FDK ABC transporter HB366_18175 ENOG4105FAV ABC, transporter HB366_18180 ENOG410829K Lysine exporter protein (Lyse ygga) HB366_18185 ENOG4105EZR dyp-type peroxidase family protein HB366_18195 ENOG4107R1I NAD-dependent malic enzyme HB366_18220 ENOG4105EUB pirin domain protein HB366_18240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HB366_18245 ENOG4106MP8 UPF0754 membrane protein HB366_18250 ENOG4108VBZ doxx family HB366_18255 ENOG4105DQR SNARE associated Golgi HB366_18270 ENOG4107QJE Chromosome Partitioning Protein HB366_18280 ENOG4107PSF BolA-like protein HB366_18300 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HB366_18325 ENOG4105C1G acyl-Coa dehydrogenase HB366_18350 ENOG4105CSH Transporter HB366_18355 ENOG4105E39 Enoyl-CoA hydratase HB366_18360 ENOG4105E39 Enoyl-CoA hydratase HB366_18365 ENOG4105C1G acyl-Coa dehydrogenase HB366_18375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HB366_18380 ENOG4105C26 Dehydrogenase HB366_18390 ENOG4105C85 amino acid HB366_18395 ENOG4105C85 amino acid HB366_18400 ENOG4105M4H endoribonuclease L-psp HB366_18415 ENOG4105EW9 transcriptional regulator AsnC family HB366_18440 ENOG4105D3G Pseudouridine synthase HB366_18455 ENOG4108IG5 Transcriptional regulator HB366_18500 ENOG4108I0Z Aconitate hydratase HB366_18505 ENOG4105BZN citrate synthase HB366_18510 ENOG4105CR4 methylisocitrate lyase HB366_18515 ENOG4105DRR Transcriptional regulator, GntR family HB366_18525 ENOG4105CGF Aromatic amino acid aminotransferase HB366_18530 ENOG4105CXG d-lactate dehydrogenase HB366_18540 ENOG41073TP transcriptional regulator HB366_18545 ENOG4105DAA L-lactate HB366_18550 ENOG4107QKV phosphomannomutase HB366_18555 ENOG4105CMR udp-glucose 4-epimerase HB366_18565 ENOG4105C6Y Udp-glucose 6-dehydrogenase HB366_18570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HB366_18575 ENOG4105D3Q Sugar transferase HB366_18580 ENOG4108RYC glycosyltransferase HB366_18585 ENOG4105CG5 Glycosyl transferase (Group 1 HB366_18600 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HB366_18605 ENOG4108UW5 maltose o-acetyltransferase HB366_18615 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HB366_18620 ENOG4105J5G Transferase hexapeptide repeat containing protein HB366_18625 ENOG4107R5Z Oxidoreductase domain protein HB366_18630 ENOG4107QQG Dehydrogenase HB366_18635 ENOG4105DAY polysaccharide export protein HB366_18645 ENOG4105D75 Capsular exopolysaccharide family HB366_18650 ENOG4108V1T peptidylprolyl cis-trans isomerase HB366_18655 ENOG4108V1T peptidylprolyl cis-trans isomerase HB366_18660 ENOG4105CJR Integral membrane protein (MviN HB366_18665 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HB366_18670 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HB366_18680 ENOG4105HSS phospholipase C HB366_18705 ENOG41062JF Transcriptional regulator HB366_18710 ENOG4108Z33 Thiol disulfide Interchange Protein HB366_18720 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HB366_18725 ENOG4105UBK short-chain dehydrogenase reductase HB366_18740 ENOG4107QZM n-acetylglutamate synthase HB366_18745 ENOG4105GVF (ABC) transporter HB366_18750 ENOG4105GVF (ABC) transporter HB366_18755 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HB366_18760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HB366_18765 ENOG4108VM9 ABC, transporter HB366_18770 ENOG4108R86 Transcriptional regulator HB366_18775 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HB366_18785 ENOG4105DTN riboflavin biosynthesis protein ribF HB366_18790 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HB366_18800 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HB366_18840 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HB366_18895 ENOG4105CVE Lytic murein transglycosylase HB366_18900 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HB366_18905 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HB366_18915 ENOG4105DFU Cell wall formation (By similarity) HB366_18925 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HB366_18930 ENOG4105DU1 integral membrane protein, terc HB366_18940 ENOG4106032 Glutathionylspermidine synthase HB366_18950 ENOG4107QUY Guanine deaminase HB366_18955 ENOG4108UGV hypoxanthine phosphoribosyltransferase HB366_18965 ENOG4105T95 Thiol disulfide interChange protein HB366_18970 ENOG4105PGM cation diffusion facilitator family transporter HB366_18985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HB366_19055 ENOG4105KK6 nuclease HB366_19060 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HB366_19115 ENOG4105FA0 parb-like partition protein HB366_19130 ENOG4105CDW Resistance protein HB366_19215 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HB366_19280 ENOG4105F9F transposase HB366_19290 ENOG4105F9F transposase HB366_19315 ENOG4105K5T PilT protein HB366_19350 ENOG4105T95 Thiol disulfide interChange protein HB366_19430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HB366_19480 ENOG4105UGU tonB-dependent Receptor