locus-tag	class	description
HB366_00010	COG0592	DNA-directed DNA polymerase activity
HB366_00020	COG0187	DNA topoisomerase II activity
HB366_00030	COG0586	Pfam SNARE associated Golgi protein
HB366_00035	COG0488	(ABC) transporter
HB366_00060	COG0596	Alpha beta hydrolase
HB366_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB366_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB366_00110	COG0733	neurotransmitter:sodium symporter activity
HB366_00150	COG2233	PERMEase
HB366_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_00200	COG2814	Major facilitator Superfamily
HB366_00205	COG0656	L-ascorbic acid biosynthetic process
HB366_00210	COG0583	DNA-binding transcription factor activity
HB366_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_00230	COG1064	alcohol dehydrogenase
HB366_00235	COG2818	Glycosylase
HB366_00250	COG1194	a g-specific adenine glycosylase
HB366_00270	COG2983	Belongs to the UPF0260 family
HB366_00275	COG2133	pyrroloquinoline quinone binding
HB366_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB366_00285	COG2116	formate transmembrane transporter activity
HB366_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_00310	COG1335	isochorismatase
HB366_00315	COG0385	Bile acid
HB366_00320	COG0534	Mate efflux family protein
HB366_00325	COG1683	Conserved Protein
HB366_00345	COG0625	glutathione transferase activity
HB366_00355	COG1113	amino acid transport
HB366_00365	COG0523	cobalamin synthesis protein
HB366_00375	COG2188	Transcriptional regulator
HB366_00405	COG0010	Belongs to the arginase family
HB366_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB366_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB366_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB366_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB366_00545	COG0534	Mate efflux family protein
HB366_00550	COG0436	Aminotransferase
HB366_00555	COG2733	membrane
HB366_00570	COG2918	glutathione biosynthetic process
HB366_00580	COG3501	Rhs element vgr protein
HB366_00585	COG0791	NLP P60 protein
HB366_00585	COG1388	LysM domain
HB366_00600	COG3150	esterase
HB366_00610	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB366_00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_00635	COG2233	PERMEase
HB366_00640	COG2351	hydroxyisourate hydrolase activity
HB366_00675	COG3706	GGDEF domain
HB366_00690	COG1393	Belongs to the ArsC family
HB366_00695	COG0708	Exodeoxyribonuclease III
HB366_00715	COG0189	ligase activity
HB366_00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB366_00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB366_00760	COG4942	peptidase
HB366_00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB366_00780	COG2119	membrane
HB366_00785	COG4774	siderophore transport
HB366_00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_00790	COG0426	domain, Protein
HB366_00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB366_00835	COG1902	pentaerythritol trinitrate reductase activity
HB366_00840	COG1519	Transferase
HB366_00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB366_00850	COG0668	transmembrane transport
HB366_00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB366_00865	COG1335	isochorismatase
HB366_00870	COG1522	sequence-specific DNA binding
HB366_00875	COG3328	transposase activity
HB366_00900	COG0784	Response regulator, receiver
HB366_00900	COG2198	Histidine kinase
HB366_00900	COG2205	protein histidine kinase activity
HB366_00905	COG3162	membrane
HB366_00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB366_00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_00930	COG3706	GGDEF domain
HB366_00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB366_00945	COG1309	transcriptional regulator
HB366_00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB366_00965	COG0351	phosphomethylpyrimidine kinase
HB366_00965	COG0352	thiamine-phosphate diphosphorylase activity
HB366_00975	COG2814	Major facilitator Superfamily
HB366_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB366_01000	COG1113	amino acid transport
HB366_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB366_01015	COG1012	belongs to the aldehyde dehydrogenase family
HB366_01025	COG1335	isochorismatase
HB366_01055	COG2814	Major facilitator Superfamily
HB366_01060	COG0583	DNA-binding transcription factor activity
HB366_01080	COG0667	Aldo Keto reductase
HB366_01110	COG1733	regulation of RNA biosynthetic process
HB366_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB366_01195	COG2329	Antibiotic biosynthesis monooxygenase
HB366_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB366_01255	COG0427	acetyl-CoA hydrolase
HB366_01270	COG0745	RESPONSE REGULATOR receiver
HB366_01280	COG0659	secondary active sulfate transmembrane transporter activity
HB366_01285	COG4221	oxidoreductase activity
HB366_01290	COG2873	o-acetylhomoserine
HB366_01295	COG0488	(ABC) transporter
HB366_01380	COG0833	amino acid
HB366_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB366_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB366_01445	COG2226	methyltransferase
HB366_01495	COG0070	glutamate synthase
HB366_01495	COG0069	glutamate synthase activity
HB366_01495	COG0067	glutamate synthase
HB366_01500	COG0493	'glutamate synthase
HB366_01510	COG1704	LemA family
HB366_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB366_01535	COG3307	-O-antigen
HB366_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB366_01570	COG0194	GDP metabolic process
HB366_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB366_01640	COG5380	lipid catabolic process
HB366_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB366_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB366_01675	COG0277	FAD linked oxidase domain protein
HB366_01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB366_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_01705	COG1289	transmembrane transporter activity
HB366_01715	COG0628	permease
HB366_01720	COG1192	Involved in chromosome partitioning
HB366_01750	COG0833	amino acid
HB366_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB366_01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB366_01770	COG1012	belongs to the aldehyde dehydrogenase family
HB366_01810	COG0583	DNA-binding transcription factor activity
HB366_01855	COG0517	IMP dehydrogenase activity
HB366_01860	COG1983	PspC domain protein
HB366_01870	COG1960	acyl-CoA dehydrogenase activity
HB366_01885	COG0408	coproporphyrinogen oxidase activity
HB366_01905	COG0513	Belongs to the DEAD box helicase family
HB366_01915	COG1127	ABC transporter
HB366_01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB366_01930	COG2854	intermembrane phospholipid transfer
HB366_01940	COG0598	Magnesium transport protein CorA
HB366_01950	COG0494	nUDIX hydrolase
HB366_01955	COG1040	competence protein
HB366_01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB366_01980	COG1946	Acyl-CoA thioesterase
HB366_01985	COG1301	dicarboxylic acid transport
HB366_02000	COG1959	2 iron, 2 sulfur cluster binding
HB366_02005	COG1017	nitric oxide dioxygenase activity
HB366_02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_02010	COG0433	COG0433 Predicted ATPase
HB366_02015	COG0626	cystathionine gamma-synthase activity
HB366_02170	COG1960	acyl-CoA dehydrogenase activity
HB366_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB366_02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB366_02210	COG0339	signal peptide processing
HB366_02215	COG0557	exoribonuclease II activity
HB366_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB366_02265	COG2169	Transcriptional regulator
HB366_02270	COG0697	spore germination
HB366_02275	COG1295	ribonuclease BN
HB366_02310	COG1702	phosphate starvation-inducible protein PhoH
HB366_02320	COG0741	lytic transglycosylase activity
HB366_02320	COG1196	nuclear chromosome segregation
HB366_02320	COG0739	heme binding
HB366_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB366_02355	COG1183	phosphatidylcholine synthase activity
HB366_02400	COG1960	acyl-CoA dehydrogenase activity
HB366_02405	COG1309	transcriptional regulator
HB366_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB366_02425	COG1960	acyl-CoA dehydrogenase activity
HB366_02445	COG2969	positive regulation of protein catabolic process
HB366_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB366_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB366_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB366_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB366_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB366_02510	COG1408	metallophosphoesterase
HB366_02520	COG2199	diguanylate cyclase activity
HB366_02580	COG1607	acyl-coa hydrolase
HB366_02610	COG2350	Protein conserved in bacteria
HB366_02620	COG0613	PHP domain protein
HB366_02625	COG3781	membrane
HB366_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB366_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB366_02650	COG1862	Preprotein translocase
HB366_02680	COG2205	protein histidine kinase activity
HB366_02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB366_02705	COG0726	polysaccharide deacetylase
HB366_02710	COG0463	Glycosyl transferase, family 2
HB366_02715	COG0438	transferase activity, transferring glycosyl groups
HB366_02780	COG0625	glutathione transferase activity
HB366_02785	COG0583	DNA-binding transcription factor activity
HB366_02790	COG1960	acyl-CoA dehydrogenase activity
HB366_02795	COG1960	acyl-CoA dehydrogenase activity
HB366_02805	COG2205	protein histidine kinase activity
HB366_02810	COG0745	RESPONSE REGULATOR receiver
HB366_02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB366_02835	COG2096	Adenosyltransferase
HB366_02885	COG0285	dihydrofolate synthase activity
HB366_02905	COG0450	alkyl hydroperoxide reductase
HB366_02920	COG0477	Major facilitator Superfamily
HB366_02925	COG1272	protein, Hemolysin III
HB366_02960	COG0183	Belongs to the thiolase family
HB366_02965	COG2207	Transcriptional regulator
HB366_02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_03005	COG0183	Belongs to the thiolase family
HB366_03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB366_03015	COG2885	chlorophyll binding
HB366_03025	COG1690	Belongs to the RtcB family
HB366_03030	COG0833	amino acid
HB366_03040	COG2233	PERMEase
HB366_03070	COG2094	Belongs to the DNA glycosylase MPG family
HB366_03075	COG4772	TonB-dependent receptor
HB366_03090	COG1902	pentaerythritol trinitrate reductase activity
HB366_03095	COG0679	Auxin Efflux Carrier
HB366_03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_03110	COG0354	folic acid binding
HB366_03120	COG3189	MarR family transcriptional regulator
HB366_03125	COG2824	Alkylphosphonate utilization operon protein PhnA
HB366_03130	COG3422	double-strand break repair
HB366_03170	COG0840	transmembrane signaling receptor activity
HB366_03190	COG5510	response to toxic substance
HB366_03200	COG2832	Protein of unknown function (DUF454)
HB366_03205	COG1376	ErfK ybiS ycfS ynhG family protein
HB366_03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB366_03255	COG1289	transmembrane transporter activity
HB366_03260	COG2814	Major facilitator Superfamily
HB366_03280	COG1115	amino acid carrier protein
HB366_03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB366_03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB366_03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB366_03335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB366_03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB366_03350	COG1077	Cell shape determining protein MreB Mrl
HB366_03355	COG1792	Involved in formation and maintenance of cell shape
HB366_03360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB366_03365	COG0424	maF-like protein
HB366_03370	COG1530	ribonuclease E activity
HB366_03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_03390	COG0560	Phosphoserine phosphatase
HB366_03400	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_03425	COG2207	Transcriptional regulator
HB366_03445	COG1113	amino acid transport
HB366_03450	COG2828	Protein conserved in bacteria
HB366_03455	COG0142	geranyltranstransferase activity
HB366_03460	COG2315	Protein conserved in bacteria
HB366_03475	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB366_03495	COG2194	sulfuric ester hydrolase activity
HB366_03500	COG0745	RESPONSE REGULATOR receiver
HB366_03505	COG0642	Histidine kinase
HB366_03515	COG0004	ammonium transporteR
HB366_03520	COG0583	DNA-binding transcription factor activity
HB366_03540	COG0525	valine-tRNA ligase activity
HB366_03550	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_03560	COG0393	Putative heavy-metal-binding
HB366_03565	COG0393	Putative heavy-metal-binding
HB366_03570	COG1538	Outer membrane efflux protein
HB366_03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_03585	COG0671	phosphoesterase, PA-phosphatase related
HB366_03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB366_03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB366_03630	COG1648	precorrin-2 dehydrogenase activity
HB366_03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB366_03640	COG1733	regulation of RNA biosynthetic process
HB366_03650	COG0531	amino acid
HB366_03665	COG0321	lipoyl(octanoyl) transferase activity
HB366_03670	COG2921	Belongs to the UPF0250 family
HB366_03710	COG2009	succinate dehydrogenase
HB366_03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB366_03720	COG1053	succinate dehydrogenase
HB366_03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB366_03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB366_03770	COG2354	Protein conserved in bacteria
HB366_03775	COG2321	neutral zinc metallopeptidase
HB366_03815	COG2843	Capsule synthesis protein
HB366_03830	COG0589	response to stress
HB366_03850	COG0505	Belongs to the CarA family
HB366_03875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB366_03880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB366_03930	COG0477	Major facilitator Superfamily
HB366_03935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB366_03950	COG1597	lipid kinase activity
HB366_03955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB366_03985	COG0584	glycerophosphoryl diester phosphodiesterase
HB366_04005	COG0741	lytic transglycosylase activity
HB366_04025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB366_04040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_04065	COG0778	Nitroreductase
HB366_04080	COG1929	Belongs to the glycerate kinase type-1 family
HB366_04085	COG0243	molybdopterin cofactor binding
HB366_04090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB366_04095	COG3339	Conserved Protein
HB366_04105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB366_04120	COG1113	amino acid transport
HB366_04130	COG0019	diaminopimelate decarboxylase activity
HB366_04140	COG1280	lysine exporter protein (LysE YggA)
HB366_04145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB366_04175	COG0463	Glycosyl transferase, family 2
HB366_04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_04230	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB366_04235	COG1136	(ABC) transporter
HB366_04240	COG2333	competence protein COMEC
HB366_04240	COG0658	competence protein
HB366_04250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB366_04250	COG0616	signal peptide processing
HB366_04255	COG0596	Alpha beta hydrolase
HB366_04260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB366_04270	COG0628	permease
HB366_04315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB366_04335	COG0823	Involved in the tonB-independent uptake of proteins
HB366_04355	COG0824	Thioesterase
HB366_04360	COG1473	amidohydrolase
HB366_04380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB366_04380	COG0047	phosphoribosylformylglycinamidine synthase activity
HB366_04385	COG2814	Major facilitator Superfamily
HB366_04395	COG1024	Enoyl-CoA hydratase
HB366_04400	COG1056	cytidyltransferase-related domain
HB366_04400	COG1051	belongs to the nudix hydrolase family
HB366_04410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB366_04425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB366_04440	COG4625	pathogenesis
HB366_04445	COG0583	DNA-binding transcription factor activity
HB366_04450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB366_04455	COG4208	sulfate ABC transporter
HB366_04460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB366_04470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB366_04475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB366_04480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB366_04500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB366_04515	COG0681	Belongs to the peptidase S26 family
HB366_04530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB366_04540	COG1381	Involved in DNA repair and RecF pathway recombination
HB366_04545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB366_04555	COG4221	oxidoreductase activity
HB366_04585	COG0436	Aminotransferase
HB366_04605	COG0556	nucleotide-excision repair
HB366_04660	COG2070	2-Nitropropane dioxygenase
HB366_04690	COG1215	transferase activity, transferring glycosyl groups
HB366_04705	COG0415	Belongs to the DNA photolyase family
HB366_04715	COG1252	NADH dehydrogenase
HB366_04720	COG1686	Belongs to the peptidase S11 family
HB366_04735	COG1187	pseudouridine synthase activity
HB366_04760	COG0477	Major facilitator Superfamily
HB366_04765	COG0583	DNA-binding transcription factor activity
HB366_04780	COG0612	Peptidase, M16
HB366_04805	COG0352	thiamine-phosphate diphosphorylase activity
HB366_04840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_04855	COG1309	transcriptional regulator
HB366_04865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB366_04870	COG0076	glutamate decarboxylase activity
HB366_04880	COG1522	sequence-specific DNA binding
HB366_04885	COG3961	Belongs to the TPP enzyme family
HB366_04890	COG1113	amino acid transport
HB366_04895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB366_04900	COG0573	inorganic phosphate transmembrane transporter activity
HB366_04910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB366_04915	COG0616	signal peptide processing
HB366_04925	COG3328	transposase activity
HB366_04955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB366_04960	COG1686	Belongs to the peptidase S11 family
HB366_04985	COG0583	DNA-binding transcription factor activity
HB366_04990	COG1067	ATP-dependent peptidase activity
HB366_05035	COG1966	Carbon starvation protein
HB366_05040	COG2879	small protein
HB366_05075	COG2508	Transcriptional regulator
HB366_05075	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HB366_05095	COG1113	amino acid transport
HB366_05100	COG0583	DNA-binding transcription factor activity
HB366_05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_05120	COG1012	belongs to the aldehyde dehydrogenase family
HB366_05125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_05130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB366_05130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HB366_05165	COG2814	Major facilitator Superfamily
HB366_05170	COG4948	Mandelate Racemase Muconate Lactonizing
HB366_05180	COG1309	transcriptional regulator
HB366_05200	COG1741	Belongs to the pirin family
HB366_05210	COG2964	Protein conserved in bacteria
HB366_05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_05230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB366_05235	COG4605	iron ion homeostasis
HB366_05240	COG4604	ABC transporter, ATP-binding protein
HB366_05245	COG4607	ABC-type enterochelin transport system periplasmic component
HB366_05250	COG4774	siderophore transport
HB366_05260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_05265	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB366_05270	COG3433	isochorismatase activity
HB366_05270	COG1535	isochorismatase
HB366_05285	COG1132	(ABC) transporter
HB366_05295	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB366_05305	COG1169	isochorismate synthase
HB366_05365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB366_05395	COG0308	aminopeptidase N
HB366_05400	COG0512	Glutamine amidotransferase of anthranilate synthase
HB366_05410	COG3104	oligopeptide transport
HB366_05415	COG0174	glutamine synthetase
HB366_05425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB366_05460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB366_05465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB366_05470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB366_05490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB366_05495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB366_05500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB366_05515	COG1960	acyl-CoA dehydrogenase activity
HB366_05520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB366_05525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB366_05535	COG2223	nitrite transmembrane transporter activity
HB366_05545	COG0024	Methionine aminopeptidase
HB366_05550	COG0052	Belongs to the universal ribosomal protein uS2 family
HB366_05565	COG2207	Transcriptional regulator
HB366_05590	COG2951	lytic endotransglycosylase activity
HB366_05595	COG0772	Belongs to the SEDS family
HB366_05620	COG0842	Transport permease protein
HB366_05625	COG1131	(ABC) transporter
HB366_05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_05685	COG4215	(ABC) transporter
HB366_05690	COG4160	amino acid transport
HB366_05695	COG4598	ABC transporter
HB366_05705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB366_05715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_05730	COG1720	tRNA m6t6A37 methyltransferase activity
HB366_05750	COG0745	RESPONSE REGULATOR receiver
HB366_05755	COG0642	Histidine kinase
HB366_05765	COG0494	nUDIX hydrolase
HB366_05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB366_05780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB366_05785	COG3139	Protein of unknown function (DUF1315)
HB366_05790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB366_05795	COG1301	dicarboxylic acid transport
HB366_05800	COG1960	acyl-CoA dehydrogenase activity
HB366_05805	COG2819	hydrolase of the alpha beta superfamily
HB366_05815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB366_05825	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB366_05830	COG1234	tRNA 3'-trailer cleavage
HB366_05860	COG2363	Small membrane protein
HB366_05880	COG0513	Belongs to the DEAD box helicase family
HB366_05890	COG0778	Nitroreductase
HB366_05920	COG1286	toxin biosynthetic process
HB366_05945	COG4783	chaperone-mediated protein folding
HB366_05950	COG1610	YqeY-like protein
HB366_06050	COG3111	PFAM Bacterial OB fold (BOF) protein
HB366_06075	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB366_06080	COG0786	glutamate:sodium symporter activity
HB366_06090	COG2186	Transcriptional regulator
HB366_06140	COG0477	Major facilitator Superfamily
HB366_06165	COG2985	domain, Protein
HB366_06175	COG2995	paraquat-inducible protein a
HB366_06180	COG3008	intermembrane lipid transfer
HB366_06180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB366_06200	COG0482	sulfurtransferase activity
HB366_06220	COG3173	Aminoglycoside phosphotransferase
HB366_06240	COG1301	dicarboxylic acid transport
HB366_06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB366_06255	COG2011	ABC-type metal ion transport system permease component
HB366_06260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB366_06265	COG1464	Belongs to the NlpA lipoprotein family
HB366_06270	COG0151	Belongs to the GarS family
HB366_06275	COG0138	bifunctional purine biosynthesis protein purh
HB366_06280	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB366_06310	COG2308	Evidence 4 Homologs of previously reported genes of
HB366_06320	COG1305	Transglutaminase-like
HB366_06330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB366_06335	COG0305	Participates in initiation and elongation during chromosome replication
HB366_06360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB366_06370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB366_06375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB366_06400	COG1649	PFAM Uncharacterised BCR, COG1649
HB366_06400	COG0726	polysaccharide deacetylase
HB366_06405	COG1215	transferase activity, transferring glycosyl groups
HB366_06410	COG3658	cytochrome
HB366_06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB366_06435	COG0583	DNA-binding transcription factor activity
HB366_06455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_06460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_06475	COG1960	acyl-CoA dehydrogenase activity
HB366_06480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB366_06485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_06510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB366_06515	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB366_06525	COG2205	protein histidine kinase activity
HB366_06530	COG0745	RESPONSE REGULATOR receiver
HB366_06535	COG0174	glutamine synthetase
HB366_06555	COG0729	surface antigen
HB366_06580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB366_06585	COG2814	Major facilitator Superfamily
HB366_06600	COG0583	DNA-binding transcription factor activity
HB366_06615	COG1187	pseudouridine synthase activity
HB366_06635	COG0802	atpase or kinase
HB366_06640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB366_06650	COG1923	regulation of RNA biosynthetic process
HB366_06655	COG0697	spore germination
HB366_06670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB366_06680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB366_06685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB366_06685	COG0519	Catalyzes the synthesis of GMP from XMP
HB366_06690	COG4302	ethanolamine ammonia-lyase activity
HB366_06695	COG4303	Ethanolamine ammonia lyase large subunit
HB366_06700	COG0531	amino acid
HB366_06720	COG1454	alcohol dehydrogenase
HB366_06725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB366_06735	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HB366_06755	COG0308	aminopeptidase N
HB366_06785	COG1605	Chorismate mutase
HB366_06800	COG1309	transcriptional regulator
HB366_06810	COG0668	transmembrane transport
HB366_06845	COG4773	Receptor
HB366_06865	COG0488	(ABC) transporter
HB366_06870	COG0589	response to stress
HB366_06895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB366_06905	COG3135	benzoate transporter
HB366_06910	COG1522	sequence-specific DNA binding
HB366_06920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB366_06925	COG0583	DNA-binding transcription factor activity
HB366_06935	COG0183	Belongs to the thiolase family
HB366_06945	COG2030	dehydratase
HB366_06965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB366_06975	COG0824	Thioesterase
HB366_06980	COG1454	alcohol dehydrogenase
HB366_06990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB366_07010	COG0069	glutamate synthase activity
HB366_07175	COG5410	chromosome segregation
HB366_07295	COG0739	heme binding
HB366_07360	COG2814	Major facilitator Superfamily
HB366_07375	COG0511	ligase activity, forming carbon-carbon bonds
HB366_07395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_07395	COG1116	anion transmembrane transporter activity
HB366_07400	COG0745	RESPONSE REGULATOR receiver
HB366_07410	COG2146	nitrite reductase [NAD(P)H] activity
HB366_07410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_07415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_07420	COG0243	molybdopterin cofactor binding
HB366_07430	COG0243	molybdopterin cofactor binding
HB366_07435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB366_07450	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB366_07450	COG0315	cyclic pyranopterin monophosphate synthase activity
HB366_07455	COG0303	'Molybdopterin
HB366_07465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_07470	COG0697	spore germination
HB366_07490	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB366_07495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB366_07560	COG2204	response regulator
HB366_07565	COG3852	Histidine kinase
HB366_07585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB366_07590	COG0575	Belongs to the CDS family
HB366_07625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB366_07640	COG2137	regulation of response to DNA damage stimulus
HB366_07650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB366_07655	COG1011	Hydrolase
HB366_07680	COG1522	sequence-specific DNA binding
HB366_07690	COG1113	amino acid transport
HB366_07705	COG0659	secondary active sulfate transmembrane transporter activity
HB366_07710	COG2135	peptidase activity
HB366_07725	COG5001	Diguanylate cyclase
HB366_07725	COG3300	MHYT domain
HB366_07745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB366_07745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB366_07745	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB366_07750	COG1105	Belongs to the carbohydrate kinase PfkB family
HB366_07755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB366_07755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB366_07785	COG0024	Methionine aminopeptidase
HB366_07790	COG0583	DNA-binding transcription factor activity
HB366_07800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB366_07805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB366_07810	COG0517	IMP dehydrogenase activity
HB366_07810	COG0516	GMP reductase activity
HB366_07835	COG0552	protein localization to endoplasmic reticulum
HB366_07845	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB366_07860	COG4890	Cyd operon protein YbgT
HB366_07865	COG1294	oxidase, subunit
HB366_07880	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB366_07890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB366_07895	COG4774	siderophore transport
HB366_07910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB366_07915	COG0569	domain protein
HB366_07920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB366_07950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB366_07955	COG0542	response to heat
HB366_07980	COG1902	pentaerythritol trinitrate reductase activity
HB366_07980	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_08025	COG2323	membrane
HB366_08030	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB366_08040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB366_08045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_08050	COG0183	Belongs to the thiolase family
HB366_08055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB366_08060	COG0596	Alpha beta hydrolase
HB366_08065	COG2271	Major facilitator Superfamily
HB366_08070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB366_08075	COG3485	protocatechuate 3,4-dioxygenase
HB366_08080	COG3485	protocatechuate 3,4-dioxygenase
HB366_08085	COG0710	3-dehydroquinate dehydratase activity
HB366_08090	COG3420	alginic acid biosynthetic process
HB366_08095	COG3659	wide pore channel activity
HB366_08100	COG4993	Dehydrogenase
HB366_08110	COG2391	methyltransferase activity
HB366_08125	COG1414	Transcriptional regulator
HB366_08130	COG0583	DNA-binding transcription factor activity
HB366_08135	COG1960	acyl-CoA dehydrogenase activity
HB366_08160	COG2814	Major facilitator Superfamily
HB366_08170	COG0154	amidase activity
HB366_08190	COG4638	Rieske (2fe-2S)
HB366_08200	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_08210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_08220	COG3733	amine oxidase
HB366_08230	COG1012	belongs to the aldehyde dehydrogenase family
HB366_08240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB366_08245	COG0183	Belongs to the thiolase family
HB366_08250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_08255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB366_08265	COG4829	muconolactone delta-isomerase
HB366_08270	COG4948	Mandelate Racemase Muconate Lactonizing
HB366_08275	COG0583	DNA-binding transcription factor activity
HB366_08285	COG2186	Transcriptional regulator
HB366_08305	COG1012	belongs to the aldehyde dehydrogenase family
HB366_08325	COG1960	acyl-CoA dehydrogenase activity
HB366_08330	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_08335	COG3829	transcription factor binding
HB366_08345	COG3162	membrane
HB366_08360	COG1012	belongs to the aldehyde dehydrogenase family
HB366_08375	COG0753	catalase activity
HB366_08395	COG1846	Transcriptional regulator
HB366_08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_08400	COG1902	pentaerythritol trinitrate reductase activity
HB366_08410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB366_08440	COG1309	transcriptional regulator
HB366_08450	COG1335	isochorismatase
HB366_08455	COG0583	DNA-binding transcription factor activity
HB366_08465	COG0475	glutathione-regulated potassium exporter activity
HB366_08465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB366_08475	COG1473	amidohydrolase
HB366_08485	COG2831	hemolysin activation secretion protein
HB366_08490	COG3210	domain, Protein
HB366_08520	COG2188	Transcriptional regulator
HB366_08535	COG0583	DNA-binding transcription factor activity
HB366_08565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB366_08585	COG1566	PFAM secretion protein HlyD family protein
HB366_08600	COG1012	belongs to the aldehyde dehydrogenase family
HB366_08605	COG0129	dihydroxy-acid dehydratase activity
HB366_08615	COG0583	DNA-binding transcription factor activity
HB366_08620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB366_08630	COG2084	Dehydrogenase
HB366_08635	COG2207	Transcriptional regulator
HB366_08650	COG1064	alcohol dehydrogenase
HB366_08665	COG1120	ATPase activity
HB366_08685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB366_08800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB366_08850	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_08865	COG2207	Transcriptional regulator
HB366_08875	COG2205	protein histidine kinase activity
HB366_08880	COG0745	RESPONSE REGULATOR receiver
HB366_08885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_08890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB366_08895	COG1538	Outer membrane efflux protein
HB366_08905	COG2072	flavoprotein involved in K transport
HB366_08925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB366_08945	COG3539	Fimbrial protein
HB366_08975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB366_08985	COG0753	catalase activity
HB366_09000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB366_09065	COG1535	isochorismatase
HB366_09065	COG3433	isochorismatase activity
HB366_09070	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_09075	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB366_09080	COG4149	molybdate abc transporter
HB366_09085	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB366_09095	COG4638	Rieske (2fe-2S)
HB366_09100	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB366_09105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_09105	COG0543	2 iron, 2 sulfur cluster binding
HB366_09130	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_09145	COG2207	Transcriptional regulator
HB366_09155	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_09160	COG2610	gluconate transmembrane transporter activity
HB366_09170	COG0583	DNA-binding transcription factor activity
HB366_09180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_09185	COG2031	fatty acid transporter
HB366_09190	COG0183	Belongs to the thiolase family
HB366_09195	COG0583	DNA-binding transcription factor activity
HB366_09200	COG0583	DNA-binding transcription factor activity
HB366_09215	COG1027	Aspartate ammonia-lyase
HB366_09225	COG0477	Major facilitator Superfamily
HB366_09245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_09250	COG4521	taurine ABC transporter
HB366_09265	COG2188	Transcriptional regulator
HB366_09275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB366_09280	COG1733	regulation of RNA biosynthetic process
HB366_09285	COG2207	Transcriptional regulator
HB366_09285	COG3708	Transcriptional regulator
HB366_09300	COG0730	response to heat
HB366_09310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB366_09310	COG3453	Protein conserved in bacteria
HB366_09320	COG3781	membrane
HB366_09325	COG1063	alcohol dehydrogenase
HB366_09335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB366_09340	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB366_09345	COG0022	dehydrogenase e1 component
HB366_09350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB366_09355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB366_09370	COG3706	GGDEF domain
HB366_09385	COG0133	tryptophan synthase activity
HB366_09395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB366_09430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB366_09455	COG2226	methyltransferase
HB366_09510	COG0842	Transport permease protein
HB366_09515	COG0842	Transport permease protein
HB366_09520	COG1131	(ABC) transporter
HB366_09535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB366_09540	COG4773	Receptor
HB366_09560	COG0730	response to heat
HB366_09565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB366_09585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB366_09640	COG4264	IucA IucC family
HB366_09645	COG4264	IucA IucC family
HB366_09665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB366_09680	COG1960	acyl-CoA dehydrogenase activity
HB366_09685	COG1960	acyl-CoA dehydrogenase activity
HB366_09690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB366_09695	COG2207	Transcriptional regulator
HB366_09700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB366_09705	COG0776	regulation of translation
HB366_09730	COG0822	iron-sulfur transferase activity
HB366_09735	COG0316	Belongs to the HesB IscA family
HB366_09765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB366_09785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB366_09790	COG0702	epimerase
HB366_09825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB366_09835	COG0339	signal peptide processing
HB366_09885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB366_09890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB366_09920	COG0776	regulation of translation
HB366_09985	COG0084	hydrolase, TatD family'
HB366_10005	COG1663	tetraacyldisaccharide 4'-kinase activity
HB366_10010	COG1132	(ABC) transporter
HB366_10020	COG0811	peptide transport
HB366_10025	COG1475	DNA binding
HB366_10030	COG1192	Involved in chromosome partitioning
HB366_10040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB366_10055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB366_10060	COG0191	fructose-bisphosphate aldolase activity
HB366_10080	COG0424	maF-like protein
HB366_10085	COG2850	peptidyl-arginine hydroxylation
HB366_10095	COG0640	Transcriptional regulator
HB366_10110	COG3619	membrane
HB366_10115	COG3122	Protein conserved in bacteria
HB366_10120	COG1132	(ABC) transporter
HB366_10140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB366_10145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB366_10155	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB366_10155	COG0506	proline dehydrogenase activity
HB366_10155	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB366_10160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB366_10175	COG3698	Phosphodiester glycosidase
HB366_10185	COG2353	YceI-like domain
HB366_10195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB366_10240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB366_10240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB366_10265	COG3539	Fimbrial protein
HB366_10270	COG3121	Chaperone
HB366_10295	COG0697	spore germination
HB366_10305	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB366_10315	COG0583	DNA-binding transcription factor activity
HB366_10335	COG1309	transcriptional regulator
HB366_10350	COG1522	sequence-specific DNA binding
HB366_10360	COG1126	abc transporter atp-binding protein
HB366_10365	COG0765	amino acid transport
HB366_10370	COG0765	amino acid transport
HB366_10400	COG1464	Belongs to the NlpA lipoprotein family
HB366_10410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB366_10415	COG2011	ABC-type metal ion transport system permease component
HB366_10420	COG0012	GTP binding
HB366_10445	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB366_10485	COG0386	Belongs to the glutathione peroxidase family
HB366_10495	COG0436	Aminotransferase
HB366_10535	COG3634	alkyl hydroperoxide reductase activity
HB366_10550	COG0583	DNA-binding transcription factor activity
HB366_10555	COG0798	PFAM Bile acid sodium symporter
HB366_10560	COG0640	Transcriptional regulator
HB366_10575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB366_10585	COG0583	DNA-binding transcription factor activity
HB366_10595	COG1953	Uracil, thiamine, allantoin
HB366_10605	COG2175	clavaminate synthase activity
HB366_10610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_10615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB366_10620	COG4521	taurine ABC transporter
HB366_10630	COG0477	Major facilitator Superfamily
HB366_10650	COG1271	oxidase subunit
HB366_10655	COG1294	oxidase, subunit
HB366_10665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_10685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB366_10705	COG3052	prosthetic group binding
HB366_10710	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB366_10720	COG2814	Major facilitator Superfamily
HB366_10740	COG1346	cytolysis
HB366_10750	COG0583	DNA-binding transcription factor activity
HB366_10755	COG0625	glutathione transferase activity
HB366_10760	COG0625	glutathione transferase activity
HB366_10765	COG0583	DNA-binding transcription factor activity
HB366_10780	COG1045	serine acetyltransferase
HB366_10785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB366_10790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB366_10800	COG1280	lysine exporter protein (LysE YggA)
HB366_10815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB366_10820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB366_10825	COG1126	abc transporter atp-binding protein
HB366_10830	COG0765	amino acid transport
HB366_10835	COG0765	amino acid transport
HB366_10855	COG0784	Response regulator, receiver
HB366_10855	COG2205	protein histidine kinase activity
HB366_10875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB366_10895	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_10945	COG0583	DNA-binding transcription factor activity
HB366_10965	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_10970	COG1309	transcriptional regulator
HB366_10975	COG1960	acyl-CoA dehydrogenase activity
HB366_10980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB366_10985	COG1024	Enoyl-CoA hydratase
HB366_10990	COG4770	biotin carboxylase activity
HB366_11000	COG0583	DNA-binding transcription factor activity
HB366_11015	COG1960	acyl-CoA dehydrogenase activity
HB366_11025	COG2814	Major facilitator Superfamily
HB366_11035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_11040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB366_11045	COG2814	Major facilitator Superfamily
HB366_11050	COG1960	acyl-CoA dehydrogenase activity
HB366_11055	COG1024	Enoyl-CoA hydratase
HB366_11060	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_11065	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB366_11070	COG0183	Belongs to the thiolase family
HB366_11080	COG2814	Major facilitator Superfamily
HB366_11090	COG1024	Enoyl-CoA hydratase
HB366_11105	COG1960	acyl-CoA dehydrogenase activity
HB366_11110	COG2814	Major facilitator Superfamily
HB366_11115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB366_11120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB366_11135	COG3842	ATPase activity
HB366_11140	COG1840	ABC-type Fe3 transport system, periplasmic component
HB366_11150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_11155	COG1414	Transcriptional regulator
HB366_11165	COG0583	DNA-binding transcription factor activity
HB366_11170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB366_11175	COG1012	belongs to the aldehyde dehydrogenase family
HB366_11185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB366_11195	COG1012	belongs to the aldehyde dehydrogenase family
HB366_11200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB366_11205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_11210	COG2267	carboxylic ester hydrolase activity
HB366_11230	COG3038	cytochrome b561
HB366_11235	COG0753	catalase activity
HB366_11270	COG2050	protein possibly involved in aromatic compounds catabolism
HB366_11280	COG3327	negative regulation of DNA-templated transcription, initiation
HB366_11285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB366_11290	COG0183	Belongs to the thiolase family
HB366_11295	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB366_11300	COG1024	Enoyl-CoA hydratase
HB366_11305	COG1024	Enoyl-CoA hydratase
HB366_11310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_11315	COG2151	metal-sulfur cluster biosynthetic enzyme
HB366_11320	COG3396	Phenylacetate-CoA oxygenase
HB366_11325	COG3460	Phenylacetate-CoA oxygenase
HB366_11330	COG3396	Phenylacetate-CoA oxygenase
HB366_11335	COG1012	belongs to the aldehyde dehydrogenase family
HB366_11335	COG2030	dehydratase
HB366_11340	COG1760	l-serine dehydratase
HB366_11345	COG0531	amino acid
HB366_11350	COG1012	belongs to the aldehyde dehydrogenase family
HB366_11365	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_11375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB366_11395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_11405	COG0789	Transcriptional regulator
HB366_11420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB366_11435	COG2807	transmembrane transport
HB366_11440	COG0590	tRNA wobble adenosine to inosine editing
HB366_11555	COG1116	anion transmembrane transporter activity
HB366_11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB366_11570	COG0864	Transcriptional regulator
HB366_11590	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_11595	COG0439	Biotin carboxylase
HB366_11610	COG1063	alcohol dehydrogenase
HB366_11620	COG1309	transcriptional regulator
HB366_11640	COG0038	chloride channel
HB366_11645	COG4770	biotin carboxylase activity
HB366_11665	COG1914	H( )-stimulated, divalent metal cation uptake system
HB366_11670	COG0583	DNA-binding transcription factor activity
HB366_11685	COG3209	COG3209 Rhs family protein
HB366_11690	COG3501	Rhs element vgr protein
HB366_11720	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB366_11740	COG2814	Major facilitator Superfamily
HB366_11750	COG1560	Kdo2-lipid A biosynthetic process
HB366_11760	COG5006	permease, DMT superfamily
HB366_11765	COG1522	sequence-specific DNA binding
HB366_11780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB366_11790	COG4122	O-methyltransferase activity
HB366_11820	COG1538	Outer membrane efflux protein
HB366_11830	COG1137	ATPase activity
HB366_11835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB366_11845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB366_11850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HB366_11850	COG0517	IMP dehydrogenase activity
HB366_11980	COG3566	protein conserved in bacteria
HB366_12000	COG3567	Phage-associated protein, HI1409 family
HB366_12005	COG5410	chromosome segregation
HB366_12090	COG4197	protein conserved in bacteria, prophage-related
HB366_12095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB366_12170	COG2814	Major facilitator Superfamily
HB366_12205	COG1278	Cold shock
HB366_12210	COG1280	lysine exporter protein (LysE YggA)
HB366_12245	COG1570	exodeoxyribonuclease VII activity
HB366_12295	COG0583	DNA-binding transcription factor activity
HB366_12300	COG4638	Rieske (2fe-2S)
HB366_12305	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB366_12310	COG0543	2 iron, 2 sulfur cluster binding
HB366_12310	COG0633	Ferredoxin
HB366_12315	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_12320	COG3135	benzoate transporter
HB366_12325	COG2814	Major facilitator Superfamily
HB366_12340	COG1643	Atp-dependent helicase
HB366_12345	COG0450	alkyl hydroperoxide reductase
HB366_12355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB366_12365	COG3634	alkyl hydroperoxide reductase activity
HB366_12385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB366_12390	COG0625	glutathione transferase activity
HB366_12400	COG2885	chlorophyll binding
HB366_12435	COG0542	response to heat
HB366_12450	COG1765	OsmC-like protein
HB366_12465	COG0667	Aldo Keto reductase
HB366_12480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB366_12490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB366_12500	COG0527	aspartate kinase activity
HB366_12510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB366_12520	COG3038	cytochrome b561
HB366_12525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB366_12530	COG2252	PERMEase
HB366_12540	COG2072	flavoprotein involved in K transport
HB366_12555	COG1741	Belongs to the pirin family
HB366_12560	COG1309	transcriptional regulator
HB366_12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_12580	COG1902	pentaerythritol trinitrate reductase activity
HB366_12590	COG2203	Gaf domain
HB366_12590	COG5001	Diguanylate cyclase
HB366_12590	COG4251	negative regulation of phosphorylation
HB366_12590	COG3706	GGDEF domain
HB366_12600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB366_12620	COG4172	Belongs to the ABC transporter superfamily
HB366_12625	COG4239	(ABC) transporter, permease
HB366_12630	COG4174	ABC transporter (Permease)
HB366_12640	COG1388	LysM domain
HB366_12640	COG0741	lytic transglycosylase activity
HB366_12640	COG1388	LysM domain
HB366_12640	COG0741	lytic transglycosylase activity
HB366_12645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB366_12685	COG0583	DNA-binding transcription factor activity
HB366_12690	COG1279	arginine transmembrane transporter activity
HB366_12710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_12715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_12720	COG0006	proline dipeptidase activity
HB366_12755	COG2194	sulfuric ester hydrolase activity
HB366_12800	COG0739	heme binding
HB366_13125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB366_13150	COG3384	dioxygenase
HB366_13160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB366_13165	COG2878	Part of a membrane complex involved in electron transport
HB366_13170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB366_13195	COG0768	penicillin binding
HB366_13200	COG0742	ribosomal rna small subunit methyltransferase
HB366_13215	COG0830	nickel cation binding
HB366_13225	COG0804	urea catabolic process
HB366_13265	COG1253	flavin adenine dinucleotide binding
HB366_13270	COG2851	Citrate transporter
HB366_13325	COG1773	rubredoxin
HB366_13330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_13340	COG0583	DNA-binding transcription factor activity
HB366_13365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB366_13370	COG4181	ATPase activity
HB366_13415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB366_13435	COG0306	phosphate transporter
HB366_13445	COG3958	Transketolase
HB366_13450	COG3959	Transketolase, thiamine diphosphate binding domain
HB366_13455	COG2271	Major facilitator Superfamily
HB366_13460	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_13465	COG0583	DNA-binding transcription factor activity
HB366_13480	COG2223	nitrite transmembrane transporter activity
HB366_13485	COG2207	Transcriptional regulator
HB366_13490	COG2066	Belongs to the glutaminase family
HB366_13495	COG0242	peptide deformylase activity
HB366_13500	COG0477	Major facilitator Superfamily
HB366_13510	COG0028	Belongs to the TPP enzyme family
HB366_13525	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_13530	COG2267	carboxylic ester hydrolase activity
HB366_13540	COG2271	Major facilitator Superfamily
HB366_13545	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_13555	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_13575	COG1414	Transcriptional regulator
HB366_13590	COG1024	Enoyl-CoA hydratase
HB366_13600	COG1215	transferase activity, transferring glycosyl groups
HB366_13605	COG0726	polysaccharide deacetylase
HB366_13605	COG1649	PFAM Uncharacterised BCR, COG1649
HB366_13615	COG4681	YaeQ
HB366_13625	COG0523	cobalamin synthesis protein
HB366_13635	COG1607	acyl-coa hydrolase
HB366_13645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_13650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_13655	COG1309	transcriptional regulator
HB366_13680	COG2040	homocysteine
HB366_13685	COG0531	amino acid
HB366_13740	COG1595	DNA-templated transcription, initiation
HB366_13750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_13755	COG0477	Major facilitator Superfamily
HB366_13775	COG0084	hydrolase, TatD family'
HB366_13810	COG0629	single-stranded DNA binding
HB366_13865	COG0582	viral genome integration into host DNA
HB366_13960	COG0592	DNA-directed DNA polymerase activity
HB366_14000	COG2026	Addiction module toxin, RelE StbE family
HB366_14235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB366_14305	COG0405	Gamma-glutamyltransferase
HB366_14310	COG2814	Major facilitator Superfamily
HB366_14320	COG2050	protein possibly involved in aromatic compounds catabolism
HB366_14335	COG1090	epimerase
HB366_14355	COG0420	3'-5' exonuclease activity
HB366_14380	COG0735	belongs to the Fur family
HB366_14385	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB366_14405	COG0121	glutamine amidotransferase
HB366_14420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB366_14430	COG0210	DNA helicase
HB366_14435	COG2885	chlorophyll binding
HB366_14440	COG0204	Acyl-transferase
HB366_14455	COG2894	cell division
HB366_14480	COG1280	lysine exporter protein (LysE YggA)
HB366_14485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB366_14485	COG1674	ftsk spoiiie
HB366_14490	COG0492	ferredoxin-NADP+ reductase activity
HB366_14495	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB366_14505	COG0456	acetyltransferase
HB366_14565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB366_14565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB366_14585	COG1012	belongs to the aldehyde dehydrogenase family
HB366_14605	COG0473	3-isopropylmalate dehydrogenase activity
HB366_14610	COG0583	DNA-binding transcription factor activity
HB366_14630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB366_14655	COG0564	pseudouridine synthase activity
HB366_14665	COG0358	DNA primase activity
HB366_14680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB366_14710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB366_14740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB366_14750	COG0352	thiamine-phosphate diphosphorylase activity
HB366_14750	COG0351	phosphomethylpyrimidine kinase
HB366_14750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB366_14755	COG1652	LysM domain
HB366_14780	COG1399	metal-binding, possibly nucleic acid-binding protein
HB366_14785	COG3101	peptidyl-lysine hydroxylation
HB366_14790	COG0009	L-threonylcarbamoyladenylate synthase
HB366_14795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB366_14800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB366_14815	COG4106	trans-aconitate 2-methyltransferase activity
HB366_14830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB366_14830	COG2226	methyltransferase
HB366_14830	COG0596	Alpha beta hydrolase
HB366_14835	COG1877	trehalose-phosphatase activity
HB366_14840	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB366_14845	COG2223	nitrite transmembrane transporter activity
HB366_14865	COG1196	nuclear chromosome segregation
HB366_14875	COG0730	response to heat
HB366_14890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB366_14900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB366_14950	COG0489	protein tyrosine kinase activity
HB366_14960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB366_14960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB366_14990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB366_14995	COG2081	HI0933 family
HB366_15005	COG0668	transmembrane transport
HB366_15025	COG0583	DNA-binding transcription factor activity
HB366_15045	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB366_15050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB366_15080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB366_15115	COG2205	protein histidine kinase activity
HB366_15120	COG0745	RESPONSE REGULATOR receiver
HB366_15140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB366_15150	COG2205	protein histidine kinase activity
HB366_15220	COG4993	Dehydrogenase
HB366_15240	COG0384	phenazine biosynthesis protein PhzF
HB366_15260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_15275	COG0583	DNA-binding transcription factor activity
HB366_15295	COG1473	amidohydrolase
HB366_15305	COG0583	DNA-binding transcription factor activity
HB366_15320	COG0583	DNA-binding transcription factor activity
HB366_15325	COG1053	succinate dehydrogenase
HB366_15335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB366_15340	COG2814	Major facilitator Superfamily
HB366_15345	COG1960	acyl-CoA dehydrogenase activity
HB366_15350	COG0583	DNA-binding transcription factor activity
HB366_15355	COG1063	alcohol dehydrogenase
HB366_15385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB366_15390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB366_15395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB366_15410	COG3667	copper resistance
HB366_15415	COG2132	Multicopper oxidase
HB366_15425	COG0561	phosphatase activity
HB366_15430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB366_15455	COG1214	PFAM Peptidase M22, glycoprotease
HB366_15505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB366_15515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB366_15520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB366_15525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB366_15585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB366_15595	COG1846	Transcriptional regulator
HB366_15600	COG1764	response to oxidative stress
HB366_15650	COG0037	tRNA processing
HB366_15660	COG0248	Ppx GppA phosphatase
HB366_15690	COG0072	phenylalanine-tRNA ligase activity
HB366_15730	COG1238	metal cluster binding
HB366_15735	COG0625	glutathione transferase activity
HB366_15750	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_15755	COG3028	Belongs to the UPF0307 family
HB366_15760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB366_15780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB366_15785	COG0617	tRNA 3'-terminal CCA addition
HB366_15790	COG1555	photosystem II stabilization
HB366_15795	COG3956	TIGRFAM MazG family protein
HB366_15805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB366_15825	COG0784	Response regulator, receiver
HB366_15825	COG5002	protein histidine kinase activity
HB366_15825	COG2205	protein histidine kinase activity
HB366_15830	COG1024	Enoyl-CoA hydratase
HB366_15835	COG2084	Dehydrogenase
HB366_15840	COG3622	Belongs to the hyi family
HB366_15870	COG0697	spore germination
HB366_15880	COG2814	Major facilitator Superfamily
HB366_15885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB366_15895	COG0583	DNA-binding transcription factor activity
HB366_15905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB366_15920	COG0084	hydrolase, TatD family'
HB366_15935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB366_15965	COG0440	acetolactate synthase activity
HB366_15970	COG0028	Belongs to the TPP enzyme family
HB366_15995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_16000	COG0577	efflux transmembrane transporter activity
HB366_16000	COG1136	(ABC) transporter
HB366_16005	COG1538	Outer membrane efflux protein
HB366_16020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB366_16025	COG1162	GTPase activity
HB366_16035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB366_16055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB366_16060	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_16100	COG2986	histidine ammonia-lyase
HB366_16115	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_16125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB366_16170	COG1426	Protein conserved in bacteria
HB366_16205	COG0793	Belongs to the peptidase S41A family
HB366_16220	COG2267	carboxylic ester hydrolase activity
HB366_16230	COG1012	belongs to the aldehyde dehydrogenase family
HB366_16235	COG3265	gluconokinase activity
HB366_16245	COG0800	Aldolase
HB366_16260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB366_16265	COG0857	belongs to the CobB CobQ family
HB366_16265	COG0280	phosphate acetyltransferase
HB366_16270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB366_16270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB366_16290	COG0740	serine-type endopeptidase activity
HB366_16310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB366_16320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB366_16320	COG2813	Specifically methylates the guanine in position
HB366_16420	COG0788	formyltetrahydrofolate deformylase activity
HB366_16445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB366_16445	COG4651	solute:proton antiporter activity
HB366_16465	COG0724	RNA recognition motif
HB366_16470	COG0210	DNA helicase
HB366_16495	COG1733	regulation of RNA biosynthetic process
HB366_16505	COG2900	Belongs to the SlyX family
HB366_16515	COG1280	lysine exporter protein (LysE YggA)
HB366_16520	COG1560	Kdo2-lipid A biosynthetic process
HB366_16530	COG1301	dicarboxylic acid transport
HB366_16585	COG0473	3-isopropylmalate dehydrogenase activity
HB366_16650	COG0583	DNA-binding transcription factor activity
HB366_16660	COG0625	glutathione transferase activity
HB366_16665	COG2378	regulation of single-species biofilm formation
HB366_16670	COG0546	phosphoglycolate phosphatase activity
HB366_16685	COG1530	ribonuclease E activity
HB366_16690	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_16705	COG0583	DNA-binding transcription factor activity
HB366_16710	COG4221	oxidoreductase activity
HB366_16715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB366_16725	COG0534	Mate efflux family protein
HB366_16740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB366_16780	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB366_16785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB366_16800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB366_16810	COG0644	oxidoreductase
HB366_16810	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB366_16815	COG0425	Belongs to the sulfur carrier protein TusA family
HB366_16820	COG4535	Mg2 and Co2 transporter CorC
HB366_16830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB366_16850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB366_16855	COG0475	glutathione-regulated potassium exporter activity
HB366_16855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB366_16860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HB366_16870	COG0484	heat shock protein binding
HB366_16875	COG0789	Transcriptional regulator
HB366_16880	COG0598	Magnesium transport protein CorA
HB366_16900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB366_16905	COG1074	ATP-dependent DNA helicase activity
HB366_16910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB366_16930	COG2226	methyltransferase
HB366_16945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_16950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB366_16965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB366_16965	COG2111	Na H antiporter
HB366_16970	COG1006	Multisubunit Na H antiporter MnhC subunit
HB366_16975	COG0651	ATP synthesis coupled electron transport
HB366_16985	COG2212	antiporter activity
HB366_17005	COG0195	Participates in both transcription termination and antitermination
HB366_17055	COG0237	dephospho-CoA kinase activity
HB366_17065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB366_17080	COG0497	DNA recombination
HB366_17090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB366_17120	COG2169	Transcriptional regulator
HB366_17120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB366_17125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB366_17190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB366_17205	COG0326	Molecular chaperone. Has ATPase activity
HB366_17220	COG2056	Na+-H+ antiporter family
HB366_17225	COG0596	Alpha beta hydrolase
HB366_17320	COG0546	phosphoglycolate phosphatase activity
HB366_17325	COG1716	ATPase activity
HB366_17370	COG0181	hydroxymethylbilane synthase activity
HB366_17380	COG3275	phosphorelay sensor kinase activity
HB366_17400	COG1538	Outer membrane efflux protein
HB366_17405	COG0697	spore germination
HB366_17430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB366_17435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB366_17440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB366_17445	COG0772	Belongs to the SEDS family
HB366_17470	COG4974	Belongs to the 'phage' integrase family
HB366_17475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_17485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB366_17495	COG2197	response regulator
HB366_17510	COG0793	Belongs to the peptidase S41A family
HB366_17515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB366_17520	COG0795	lipopolysaccharide-transporting ATPase activity
HB366_17560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB366_17560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB366_17570	COG0004	ammonium transporteR
HB366_17575	COG0347	Belongs to the P(II) protein family
HB366_17585	COG0606	chelatase, subunit chli
HB366_17660	COG1061	Type III restriction enzyme res subunit
HB366_17675	COG0659	secondary active sulfate transmembrane transporter activity
HB366_17680	COG0589	response to stress
HB366_17725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB366_17770	COG1061	Type III restriction enzyme res subunit
HB366_17805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB366_17835	COG0659	secondary active sulfate transmembrane transporter activity
HB366_17840	COG0589	response to stress
HB366_17870	COG0606	chelatase, subunit chli
HB366_17885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_17900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB366_17915	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_17925	COG0477	Major facilitator Superfamily
HB366_17930	COG2860	membrane
HB366_17940	COG1253	flavin adenine dinucleotide binding
HB366_17960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB366_17995	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB366_18005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB366_18040	COG1309	transcriptional regulator
HB366_18075	COG0758	DNA mediated transformation
HB366_18085	COG0697	spore germination
HB366_18090	COG1309	transcriptional regulator
HB366_18105	COG0386	Belongs to the glutathione peroxidase family
HB366_18170	COG1121	(ABC) transporter
HB366_18175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB366_18180	COG1280	lysine exporter protein (LysE YggA)
HB366_18185	COG2837	iron assimilation
HB366_18195	COG0281	malic enzyme
HB366_18240	COG0519	Catalyzes the synthesis of GMP from XMP
HB366_18240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB366_18245	COG4399	Belongs to the UPF0754 family
HB366_18250	COG2259	Doxx family
HB366_18255	COG0586	Pfam SNARE associated Golgi protein
HB366_18270	COG1192	Involved in chromosome partitioning
HB366_18280	COG0271	Belongs to the BolA IbaG family
HB366_18300	COG2267	carboxylic ester hydrolase activity
HB366_18320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB366_18320	COG3321	synthase
HB366_18320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB366_18320	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HB366_18325	COG1960	acyl-CoA dehydrogenase activity
HB366_18335	COG2197	response regulator
HB366_18345	COG3916	Acyl-homoserine-lactone synthase
HB366_18350	COG0477	Major facilitator Superfamily
HB366_18355	COG1024	Enoyl-CoA hydratase
HB366_18360	COG1024	Enoyl-CoA hydratase
HB366_18365	COG1960	acyl-CoA dehydrogenase activity
HB366_18370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB366_18390	COG1113	amino acid transport
HB366_18395	COG1113	amino acid transport
HB366_18400	COG0251	oxidation-reduction process
HB366_18440	COG0564	pseudouridine synthase activity
HB366_18500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB366_18515	COG1802	Transcriptional regulator
HB366_18525	COG1448	Aminotransferase
HB366_18530	COG0277	FAD linked oxidase domain protein
HB366_18540	COG2186	Transcriptional regulator
HB366_18550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB366_18555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB366_18570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB366_18575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB366_18600	COG0438	transferase activity, transferring glycosyl groups
HB366_18630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB366_18660	COG0728	peptidoglycan biosynthetic process
HB366_18665	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB366_18720	COG0546	phosphoglycolate phosphatase activity
HB366_18725	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_18745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_18750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_18755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB366_18760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_18765	COG1116	anion transmembrane transporter activity
HB366_18770	COG1309	transcriptional regulator
HB366_18775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB366_18785	COG0196	riboflavin kinase activity
HB366_18790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB366_18800	COG1047	Peptidyl-prolyl cis-trans
HB366_18840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB366_18895	COG2951	lytic endotransglycosylase activity
HB366_18900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB366_18915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB366_18925	COG0671	phosphoesterase, PA-phosphatase related
HB366_18930	COG0861	Integral membrane protein TerC family
HB366_18940	COG0754	glutathionylspermidine amidase activity
HB366_18950	COG0402	S-adenosylhomocysteine deaminase activity
HB366_18965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_18970	COG1230	cation diffusion facilitator family transporter
HB366_18985	COG0706	membrane insertase activity
HB366_19055	COG1525	nuclease
HB366_19115	COG1475	DNA binding
HB366_19130	COG3853	Toxic anion resistance protein (TelA)
HB366_19215	COG0484	heat shock protein binding
HB366_19280	COG2826	transposase and inactivated derivatives, IS30 family
HB366_19290	COG2826	transposase and inactivated derivatives, IS30 family
HB366_19315	COG0741	lytic transglycosylase activity
HB366_19350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_19430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII