locus-tag	class	description
HB367_00020	COG0582	viral genome integration into host DNA
HB367_00030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB367_00055	COG1012	belongs to the aldehyde dehydrogenase family
HB367_00075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB367_00075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB367_00135	COG0456	acetyltransferase
HB367_00145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB367_00150	COG0492	ferredoxin-NADP+ reductase activity
HB367_00155	COG1674	ftsk spoiiie
HB367_00155	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB367_00160	COG1280	lysine exporter protein (LysE YggA)
HB367_00175	COG2894	cell division
HB367_00190	COG0204	Acyl-transferase
HB367_00195	COG2885	chlorophyll binding
HB367_00200	COG0210	DNA helicase
HB367_00210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_00225	COG0121	glutamine amidotransferase
HB367_00245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB367_00250	COG0735	belongs to the Fur family
HB367_00275	COG0420	3'-5' exonuclease activity
HB367_00295	COG1090	epimerase
HB367_00310	COG2050	protein possibly involved in aromatic compounds catabolism
HB367_00320	COG2814	Major facilitator Superfamily
HB367_00325	COG0405	Gamma-glutamyltransferase
HB367_00355	COG0477	Major facilitator Superfamily
HB367_00360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_00370	COG1595	DNA-templated transcription, initiation
HB367_00425	COG0531	amino acid
HB367_00430	COG2040	homocysteine
HB367_00455	COG1309	transcriptional regulator
HB367_00460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB367_00465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB367_00475	COG1607	acyl-coa hydrolase
HB367_00485	COG0523	cobalamin synthesis protein
HB367_00495	COG4681	YaeQ
HB367_00505	COG1649	PFAM Uncharacterised BCR, COG1649
HB367_00505	COG0726	polysaccharide deacetylase
HB367_00510	COG1215	transferase activity, transferring glycosyl groups
HB367_00520	COG1024	Enoyl-CoA hydratase
HB367_00535	COG1414	Transcriptional regulator
HB367_00555	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_00570	COG2271	Major facilitator Superfamily
HB367_00580	COG2267	carboxylic ester hydrolase activity
HB367_00585	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_00600	COG0028	Belongs to the TPP enzyme family
HB367_00610	COG0477	Major facilitator Superfamily
HB367_00615	COG0242	peptide deformylase activity
HB367_00620	COG2066	Belongs to the glutaminase family
HB367_00625	COG2207	Transcriptional regulator
HB367_00630	COG2223	nitrite transmembrane transporter activity
HB367_00665	COG0306	phosphate transporter
HB367_00685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB367_00730	COG4181	ATPase activity
HB367_00735	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB367_00765	COG0583	DNA-binding transcription factor activity
HB367_00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_00780	COG1773	rubredoxin
HB367_00830	COG2851	Citrate transporter
HB367_00835	COG1253	flavin adenine dinucleotide binding
HB367_00875	COG0804	urea catabolic process
HB367_00885	COG0830	nickel cation binding
HB367_00900	COG0742	ribosomal rna small subunit methyltransferase
HB367_00905	COG0768	penicillin binding
HB367_00930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB367_00935	COG2878	Part of a membrane complex involved in electron transport
HB367_00940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB367_00950	COG3384	dioxygenase
HB367_00970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB367_01025	COG3620	sequence-specific DNA binding
HB367_01145	COG2194	sulfuric ester hydrolase activity
HB367_01175	COG0006	proline dipeptidase activity
HB367_01180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_01185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_01205	COG1279	arginine transmembrane transporter activity
HB367_01210	COG0583	DNA-binding transcription factor activity
HB367_01250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_01255	COG1388	LysM domain
HB367_01255	COG0741	lytic transglycosylase activity
HB367_01265	COG4174	ABC transporter (Permease)
HB367_01270	COG4239	(ABC) transporter, permease
HB367_01275	COG4172	Belongs to the ABC transporter superfamily
HB367_01295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_01305	COG5001	Diguanylate cyclase
HB367_01305	COG2203	Gaf domain
HB367_01305	COG3706	GGDEF domain
HB367_01305	COG4251	negative regulation of phosphorylation
HB367_01315	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB367_01315	COG1902	pentaerythritol trinitrate reductase activity
HB367_01325	COG0582	viral genome integration into host DNA
HB367_01335	COG3328	transposase activity
HB367_01345	COG2161	toxin-antitoxin pair type II binding
HB367_01450	COG0514	ATP-dependent DNA helicase (RecQ)
HB367_01475	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB367_01475	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB367_01500	COG2826	transposase and inactivated derivatives, IS30 family
HB367_01530	COG1113	amino acid transport
HB367_01560	COG1012	belongs to the aldehyde dehydrogenase family
HB367_01580	COG1113	amino acid transport
HB367_01605	COG0697	spore germination
HB367_01610	COG2721	sulfolactate sulfo-lyase activity
HB367_01615	COG2271	Major facilitator Superfamily
HB367_01620	COG4948	Mandelate Racemase Muconate Lactonizing
HB367_01630	COG1012	belongs to the aldehyde dehydrogenase family
HB367_01635	COG2186	Transcriptional regulator
HB367_01660	COG1960	acyl-CoA dehydrogenase activity
HB367_01670	COG1012	belongs to the aldehyde dehydrogenase family
HB367_01675	COG1024	Enoyl-CoA hydratase
HB367_01680	COG2814	Major facilitator Superfamily
HB367_01695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_01755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB367_01760	COG2072	flavoprotein involved in K transport
HB367_01765	COG0300	oxidoreductase activity
HB367_01775	COG1309	transcriptional regulator
HB367_01780	COG1741	Belongs to the pirin family
HB367_01795	COG2072	flavoprotein involved in K transport
HB367_01805	COG2252	PERMEase
HB367_01810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB367_01815	COG3038	cytochrome b561
HB367_01825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB367_01835	COG0527	aspartate kinase activity
HB367_01875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_01970	COG1484	DNA-dependent DNA replication
HB367_02015	COG3755	Protein conserved in bacteria
HB367_02200	COG0592	DNA-directed DNA polymerase activity
HB367_02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB367_02290	COG2826	transposase and inactivated derivatives, IS30 family
HB367_02305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB367_02315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB367_02330	COG0667	Aldo Keto reductase
HB367_02340	COG1765	OsmC-like protein
HB367_02350	COG3328	transposase activity
HB367_02365	COG0542	response to heat
HB367_02400	COG2885	chlorophyll binding
HB367_02410	COG0625	glutathione transferase activity
HB367_02430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB367_02450	COG3634	alkyl hydroperoxide reductase activity
HB367_02460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB367_02470	COG0450	alkyl hydroperoxide reductase
HB367_02475	COG1643	Atp-dependent helicase
HB367_02490	COG2814	Major facilitator Superfamily
HB367_02495	COG3135	benzoate transporter
HB367_02500	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_02505	COG0543	2 iron, 2 sulfur cluster binding
HB367_02505	COG0633	Ferredoxin
HB367_02510	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB367_02515	COG4638	Rieske (2fe-2S)
HB367_02520	COG0583	DNA-binding transcription factor activity
HB367_02570	COG1570	exodeoxyribonuclease VII activity
HB367_02610	COG1280	lysine exporter protein (LysE YggA)
HB367_02615	COG1278	Cold shock
HB367_02650	COG2814	Major facilitator Superfamily
HB367_02680	COG2826	transposase and inactivated derivatives, IS30 family
HB367_02705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB367_02715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB367_02720	COG1137	ATPase activity
HB367_02730	COG1538	Outer membrane efflux protein
HB367_02760	COG4122	O-methyltransferase activity
HB367_02770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB367_02785	COG1522	sequence-specific DNA binding
HB367_02790	COG5006	permease, DMT superfamily
HB367_02800	COG1560	Kdo2-lipid A biosynthetic process
HB367_02810	COG2814	Major facilitator Superfamily
HB367_02830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB367_02855	COG2826	transposase and inactivated derivatives, IS30 family
HB367_02870	COG0583	DNA-binding transcription factor activity
HB367_02875	COG1914	H( )-stimulated, divalent metal cation uptake system
HB367_02895	COG4770	biotin carboxylase activity
HB367_02900	COG0038	chloride channel
HB367_02915	COG3328	transposase activity
HB367_02920	COG1309	transcriptional regulator
HB367_02930	COG1063	alcohol dehydrogenase
HB367_02945	COG0439	Biotin carboxylase
HB367_02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB367_02955	COG1733	regulation of RNA biosynthetic process
HB367_02970	COG0864	Transcriptional regulator
HB367_02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB367_02985	COG1116	anion transmembrane transporter activity
HB367_03035	COG2826	transposase and inactivated derivatives, IS30 family
HB367_03110	COG2826	transposase and inactivated derivatives, IS30 family
HB367_03170	COG0590	tRNA wobble adenosine to inosine editing
HB367_03175	COG2807	transmembrane transport
HB367_03190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB367_03200	COG0789	Transcriptional regulator
HB367_03210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_03255	COG1012	belongs to the aldehyde dehydrogenase family
HB367_03260	COG0531	amino acid
HB367_03265	COG1760	l-serine dehydratase
HB367_03270	COG1012	belongs to the aldehyde dehydrogenase family
HB367_03270	COG2030	dehydratase
HB367_03275	COG3396	Phenylacetate-CoA oxygenase
HB367_03280	COG3460	Phenylacetate-CoA oxygenase
HB367_03285	COG3396	Phenylacetate-CoA oxygenase
HB367_03290	COG2151	metal-sulfur cluster biosynthetic enzyme
HB367_03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_03300	COG1024	Enoyl-CoA hydratase
HB367_03305	COG1024	Enoyl-CoA hydratase
HB367_03310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB367_03315	COG0183	Belongs to the thiolase family
HB367_03320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB367_03325	COG3327	negative regulation of DNA-templated transcription, initiation
HB367_03335	COG2050	protein possibly involved in aromatic compounds catabolism
HB367_03350	COG3328	transposase activity
HB367_03355	COG0406	alpha-ribazole phosphatase activity
HB367_03390	COG0753	catalase activity
HB367_03395	COG3038	cytochrome b561
HB367_03400	COG0583	DNA-binding transcription factor activity
HB367_03410	COG1414	Transcriptional regulator
HB367_03415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_03430	COG1840	ABC-type Fe3 transport system, periplasmic component
HB367_03435	COG3842	ATPase activity
HB367_03450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB367_03455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB367_03460	COG2814	Major facilitator Superfamily
HB367_03465	COG1960	acyl-CoA dehydrogenase activity
HB367_03480	COG1024	Enoyl-CoA hydratase
HB367_03490	COG2814	Major facilitator Superfamily
HB367_03500	COG0183	Belongs to the thiolase family
HB367_03505	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB367_03510	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_03515	COG1024	Enoyl-CoA hydratase
HB367_03520	COG1960	acyl-CoA dehydrogenase activity
HB367_03525	COG2814	Major facilitator Superfamily
HB367_03530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB367_03535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB367_03545	COG2814	Major facilitator Superfamily
HB367_03555	COG1960	acyl-CoA dehydrogenase activity
HB367_03570	COG0583	DNA-binding transcription factor activity
HB367_03580	COG4770	biotin carboxylase activity
HB367_03585	COG1024	Enoyl-CoA hydratase
HB367_03590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB367_03595	COG1960	acyl-CoA dehydrogenase activity
HB367_03600	COG1309	transcriptional regulator
HB367_03605	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_03625	COG0583	DNA-binding transcription factor activity
HB367_03675	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_03695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB367_03715	COG2205	protein histidine kinase activity
HB367_03715	COG0784	Response regulator, receiver
HB367_03735	COG0765	amino acid transport
HB367_03740	COG0765	amino acid transport
HB367_03745	COG1126	abc transporter atp-binding protein
HB367_03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB367_03755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB367_03765	COG1280	lysine exporter protein (LysE YggA)
HB367_03770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB367_03775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB367_03780	COG1045	serine acetyltransferase
HB367_03790	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_03795	COG0583	DNA-binding transcription factor activity
HB367_03800	COG0625	glutathione transferase activity
HB367_03805	COG0625	glutathione transferase activity
HB367_03810	COG0583	DNA-binding transcription factor activity
HB367_03820	COG1346	cytolysis
HB367_03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_03840	COG2814	Major facilitator Superfamily
HB367_03850	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB367_03855	COG3052	prosthetic group binding
HB367_03875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB367_03895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_03905	COG1294	oxidase, subunit
HB367_03910	COG1271	oxidase subunit
HB367_03930	COG0477	Major facilitator Superfamily
HB367_03940	COG4521	taurine ABC transporter
HB367_03945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB367_03950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB367_03955	COG2175	clavaminate synthase activity
HB367_03965	COG1953	Uracil, thiamine, allantoin
HB367_03975	COG0583	DNA-binding transcription factor activity
HB367_04010	COG0640	Transcriptional regulator
HB367_04015	COG0798	PFAM Bile acid sodium symporter
HB367_04020	COG0583	DNA-binding transcription factor activity
HB367_04035	COG3634	alkyl hydroperoxide reductase activity
HB367_04070	COG1301	dicarboxylic acid transport
HB367_04075	COG0436	Aminotransferase
HB367_04085	COG0386	Belongs to the glutathione peroxidase family
HB367_04125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB367_04150	COG0012	GTP binding
HB367_04155	COG2011	ABC-type metal ion transport system permease component
HB367_04160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB367_04170	COG1464	Belongs to the NlpA lipoprotein family
HB367_04200	COG0765	amino acid transport
HB367_04205	COG0765	amino acid transport
HB367_04210	COG1126	abc transporter atp-binding protein
HB367_04220	COG1522	sequence-specific DNA binding
HB367_04235	COG1309	transcriptional regulator
HB367_04255	COG2826	transposase and inactivated derivatives, IS30 family
HB367_04260	COG0583	DNA-binding transcription factor activity
HB367_04270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB367_04295	COG3121	Chaperone
HB367_04300	COG3539	Fimbrial protein
HB367_04325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB367_04325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB367_04370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB367_04380	COG2353	YceI-like domain
HB367_04390	COG3698	Phosphodiester glycosidase
HB367_04405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB367_04410	COG0506	proline dehydrogenase activity
HB367_04410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB367_04410	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB367_04420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB367_04425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB367_04440	COG2826	transposase and inactivated derivatives, IS30 family
HB367_04455	COG1132	(ABC) transporter
HB367_04460	COG3328	transposase activity
HB367_04465	COG3122	Protein conserved in bacteria
HB367_04470	COG3619	membrane
HB367_04480	COG0640	Transcriptional regulator
HB367_04490	COG2850	peptidyl-arginine hydroxylation
HB367_04495	COG0424	maF-like protein
HB367_04515	COG0191	fructose-bisphosphate aldolase activity
HB367_04520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB367_04535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB367_04545	COG1192	Involved in chromosome partitioning
HB367_04550	COG1475	DNA binding
HB367_04555	COG0811	peptide transport
HB367_04565	COG1132	(ABC) transporter
HB367_04570	COG1663	tetraacyldisaccharide 4'-kinase activity
HB367_04590	COG0084	hydrolase, TatD family'
HB367_04655	COG0776	regulation of translation
HB367_04685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB367_04690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB367_04735	COG4166	transmembrane transport
HB367_04740	COG0339	signal peptide processing
HB367_04745	COG0601	transmembrane transport
HB367_04785	COG0702	epimerase
HB367_04790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB367_04810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB367_04840	COG0316	Belongs to the HesB IscA family
HB367_04845	COG0822	iron-sulfur transferase activity
HB367_04870	COG0776	regulation of translation
HB367_04875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB367_04880	COG2207	Transcriptional regulator
HB367_04885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB367_04890	COG1960	acyl-CoA dehydrogenase activity
HB367_04895	COG1960	acyl-CoA dehydrogenase activity
HB367_04910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB367_04925	COG2814	Major facilitator Superfamily
HB367_04930	COG4264	IucA IucC family
HB367_04935	COG4264	IucA IucC family
HB367_04945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB367_04990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB367_04995	COG0406	alpha-ribazole phosphatase activity
HB367_05010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB367_05015	COG0730	response to heat
HB367_05035	COG4773	Receptor
HB367_05040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB367_05055	COG1131	(ABC) transporter
HB367_05060	COG0842	Transport permease protein
HB367_05065	COG0842	Transport permease protein
HB367_05090	COG0537	adenosine 5'-monophosphoramidase activity
HB367_05100	COG2826	transposase and inactivated derivatives, IS30 family
HB367_05125	COG2226	methyltransferase
HB367_05150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB367_05185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB367_05195	COG0133	tryptophan synthase activity
HB367_05210	COG3706	GGDEF domain
HB367_05225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB367_05230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB367_05235	COG0022	dehydrogenase e1 component
HB367_05240	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB367_05245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB367_05255	COG1063	alcohol dehydrogenase
HB367_05260	COG3781	membrane
HB367_05270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB367_05270	COG3453	Protein conserved in bacteria
HB367_05280	COG0730	response to heat
HB367_05295	COG2207	Transcriptional regulator
HB367_05295	COG3708	Transcriptional regulator
HB367_05300	COG1733	regulation of RNA biosynthetic process
HB367_05305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB367_05315	COG2188	Transcriptional regulator
HB367_05330	COG4521	taurine ABC transporter
HB367_05335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB367_05355	COG0477	Major facilitator Superfamily
HB367_05365	COG1027	Aspartate ammonia-lyase
HB367_05380	COG0583	DNA-binding transcription factor activity
HB367_05385	COG0583	DNA-binding transcription factor activity
HB367_05390	COG0183	Belongs to the thiolase family
HB367_05395	COG2031	fatty acid transporter
HB367_05410	COG0583	DNA-binding transcription factor activity
HB367_05420	COG2610	gluconate transmembrane transporter activity
HB367_05425	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_05430	COG2207	Transcriptional regulator
HB367_05450	COG3328	transposase activity
HB367_05465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_05480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_05480	COG0543	2 iron, 2 sulfur cluster binding
HB367_05485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB367_05490	COG4638	Rieske (2fe-2S)
HB367_05500	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB367_05505	COG4149	molybdate abc transporter
HB367_05510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB367_05515	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_05520	COG3433	isochorismatase activity
HB367_05520	COG1535	isochorismatase
HB367_05585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB367_05600	COG0753	catalase activity
HB367_05610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB367_05635	COG3539	Fimbrial protein
HB367_05655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB367_05670	COG2072	flavoprotein involved in K transport
HB367_05680	COG1538	Outer membrane efflux protein
HB367_05685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB367_05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_05695	COG0745	RESPONSE REGULATOR receiver
HB367_05700	COG2205	protein histidine kinase activity
HB367_05710	COG2207	Transcriptional regulator
HB367_05725	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_05735	COG1073	alpha beta
HB367_05770	COG0556	nucleotide-excision repair
HB367_05785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB367_05840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB367_05860	COG1120	ATPase activity
HB367_05880	COG2084	Dehydrogenase
HB367_05890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB367_05895	COG0583	DNA-binding transcription factor activity
HB367_05905	COG0129	dihydroxy-acid dehydratase activity
HB367_05910	COG1012	belongs to the aldehyde dehydrogenase family
HB367_05925	COG1566	PFAM secretion protein HlyD family protein
HB367_05950	COG0583	DNA-binding transcription factor activity
HB367_05965	COG2188	Transcriptional regulator
HB367_06010	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_06020	COG1960	acyl-CoA dehydrogenase activity
HB367_06030	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_06035	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_06040	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_06045	COG0583	DNA-binding transcription factor activity
HB367_06050	COG1309	transcriptional regulator
HB367_06090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB367_06090	COG1902	pentaerythritol trinitrate reductase activity
HB367_06105	COG1012	belongs to the aldehyde dehydrogenase family
HB367_06125	COG2186	Transcriptional regulator
HB367_06135	COG0583	DNA-binding transcription factor activity
HB367_06140	COG4948	Mandelate Racemase Muconate Lactonizing
HB367_06145	COG4829	muconolactone delta-isomerase
HB367_06155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB367_06160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB367_06165	COG0183	Belongs to the thiolase family
HB367_06170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB367_06180	COG1012	belongs to the aldehyde dehydrogenase family
HB367_06190	COG3733	amine oxidase
HB367_06200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_06210	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_06220	COG4638	Rieske (2fe-2S)
HB367_06240	COG0154	amidase activity
HB367_06250	COG2814	Major facilitator Superfamily
HB367_06275	COG1960	acyl-CoA dehydrogenase activity
HB367_06280	COG0583	DNA-binding transcription factor activity
HB367_06285	COG1414	Transcriptional regulator
HB367_06300	COG2391	methyltransferase activity
HB367_06310	COG4993	Dehydrogenase
HB367_06315	COG3659	wide pore channel activity
HB367_06320	COG3420	alginic acid biosynthetic process
HB367_06325	COG0710	3-dehydroquinate dehydratase activity
HB367_06330	COG3485	protocatechuate 3,4-dioxygenase
HB367_06335	COG3485	protocatechuate 3,4-dioxygenase
HB367_06340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB367_06345	COG2271	Major facilitator Superfamily
HB367_06350	COG0596	Alpha beta hydrolase
HB367_06355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB367_06360	COG0183	Belongs to the thiolase family
HB367_06365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB367_06370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB367_06380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB367_06385	COG2323	membrane
HB367_06430	COG1902	pentaerythritol trinitrate reductase activity
HB367_06430	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB367_06455	COG0542	response to heat
HB367_06460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB367_06495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB367_06500	COG0569	domain protein
HB367_06505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB367_06520	COG4774	siderophore transport
HB367_06525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB367_06535	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB367_06540	COG2826	transposase and inactivated derivatives, IS30 family
HB367_06555	COG1294	oxidase, subunit
HB367_06560	COG4890	Cyd operon protein YbgT
HB367_06575	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB367_06585	COG0552	protein localization to endoplasmic reticulum
HB367_06610	COG0517	IMP dehydrogenase activity
HB367_06610	COG0516	GMP reductase activity
HB367_06615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB367_06620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB367_06630	COG0583	DNA-binding transcription factor activity
HB367_06635	COG0024	Methionine aminopeptidase
HB367_06665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB367_06665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB367_06670	COG1105	Belongs to the carbohydrate kinase PfkB family
HB367_06675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB367_06675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB367_06675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB367_06690	COG5001	Diguanylate cyclase
HB367_06690	COG3300	MHYT domain
HB367_06705	COG2135	peptidase activity
HB367_06710	COG0659	secondary active sulfate transmembrane transporter activity
HB367_06725	COG1113	amino acid transport
HB367_06735	COG1522	sequence-specific DNA binding
HB367_06760	COG1011	Hydrolase
HB367_06765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB367_06775	COG2137	regulation of response to DNA damage stimulus
HB367_06790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB367_06810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB367_06825	COG0575	Belongs to the CDS family
HB367_06830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB367_06855	COG3852	Histidine kinase
HB367_06860	COG2204	response regulator
HB367_06915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB367_06920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB367_06940	COG0697	spore germination
HB367_06945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_06955	COG0303	'Molybdopterin
HB367_06960	COG0315	cyclic pyranopterin monophosphate synthase activity
HB367_06960	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB367_06975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB367_06990	COG0243	molybdopterin cofactor binding
HB367_06995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_07000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_07000	COG2146	nitrite reductase [NAD(P)H] activity
HB367_07010	COG0745	RESPONSE REGULATOR receiver
HB367_07015	COG1116	anion transmembrane transporter activity
HB367_07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB367_07035	COG0511	ligase activity, forming carbon-carbon bonds
HB367_07050	COG2814	Major facilitator Superfamily
HB367_07080	COG3293	Transposase
HB367_07085	COG1063	alcohol dehydrogenase
HB367_07095	COG3179	chitinase
HB367_07145	COG1598	PFAM Uncharacterised protein family UPF0150
HB367_07245	COG5410	chromosome segregation
HB367_07400	COG0069	glutamate synthase activity
HB367_07430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB367_07440	COG1454	alcohol dehydrogenase
HB367_07445	COG0824	Thioesterase
HB367_07455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB367_07485	COG2030	dehydratase
HB367_07495	COG0183	Belongs to the thiolase family
HB367_07505	COG0583	DNA-binding transcription factor activity
HB367_07510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB367_07520	COG1522	sequence-specific DNA binding
HB367_07525	COG3135	benzoate transporter
HB367_07535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB367_07560	COG0589	response to stress
HB367_07565	COG0488	(ABC) transporter
HB367_07585	COG4773	Receptor
HB367_07595	COG3328	transposase activity
HB367_07625	COG0668	transmembrane transport
HB367_07635	COG1309	transcriptional regulator
HB367_07650	COG1605	Chorismate mutase
HB367_07690	COG0308	aminopeptidase N
HB367_07715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB367_07720	COG1454	alcohol dehydrogenase
HB367_07740	COG0531	amino acid
HB367_07745	COG4303	Ethanolamine ammonia lyase large subunit
HB367_07750	COG4302	ethanolamine ammonia-lyase activity
HB367_07755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB367_07755	COG0519	Catalyzes the synthesis of GMP from XMP
HB367_07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB367_07770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB367_07785	COG0697	spore germination
HB367_07790	COG1923	regulation of RNA biosynthetic process
HB367_07800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB367_07805	COG0802	atpase or kinase
HB367_07825	COG1187	pseudouridine synthase activity
HB367_07840	COG0583	DNA-binding transcription factor activity
HB367_07855	COG2814	Major facilitator Superfamily
HB367_07860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB367_07985	COG0729	surface antigen
HB367_08005	COG0174	glutamine synthetase
HB367_08010	COG0745	RESPONSE REGULATOR receiver
HB367_08015	COG2205	protein histidine kinase activity
HB367_08020	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB367_08025	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB367_08030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB367_08055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_08060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB367_08065	COG1960	acyl-CoA dehydrogenase activity
HB367_08095	COG0583	DNA-binding transcription factor activity
HB367_08110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB367_08120	COG3658	cytochrome
HB367_08125	COG1215	transferase activity, transferring glycosyl groups
HB367_08130	COG1649	PFAM Uncharacterised BCR, COG1649
HB367_08130	COG0726	polysaccharide deacetylase
HB367_08155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB367_08160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB367_08170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB367_08195	COG0305	Participates in initiation and elongation during chromosome replication
HB367_08200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB367_08210	COG1305	Transglutaminase-like
HB367_08220	COG2308	Evidence 4 Homologs of previously reported genes of
HB367_08250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB367_08255	COG0138	bifunctional purine biosynthesis protein purh
HB367_08260	COG0151	Belongs to the GarS family
HB367_08265	COG1464	Belongs to the NlpA lipoprotein family
HB367_08270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB367_08275	COG2011	ABC-type metal ion transport system permease component
HB367_08280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB367_08290	COG1301	dicarboxylic acid transport
HB367_08320	COG1794	racemase activity, acting on amino acids and derivatives
HB367_08340	COG0745	RESPONSE REGULATOR receiver
HB367_08345	COG0642	Histidine kinase
HB367_08350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB367_08360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB367_08400	COG2351	hydroxyisourate hydrolase activity
HB367_08410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB367_08410	COG3008	intermembrane lipid transfer
HB367_08415	COG2995	paraquat-inducible protein a
HB367_08445	COG1051	belongs to the nudix hydrolase family
HB367_08450	COG2186	Transcriptional regulator
HB367_08460	COG0786	glutamate:sodium symporter activity
HB367_08465	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB367_08490	COG3111	PFAM Bacterial OB fold (BOF) protein
HB367_08590	COG1610	YqeY-like protein
HB367_08595	COG4783	chaperone-mediated protein folding
HB367_08620	COG1286	toxin biosynthetic process
HB367_08755	COG0778	Nitroreductase
HB367_08765	COG0513	Belongs to the DEAD box helicase family
HB367_08785	COG2363	Small membrane protein
HB367_08815	COG4650	regulator
HB367_08820	COG1234	tRNA 3'-trailer cleavage
HB367_08825	COG1690	Belongs to the RtcB family
HB367_08845	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB367_08855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB367_08870	COG1960	acyl-CoA dehydrogenase activity
HB367_08875	COG1301	dicarboxylic acid transport
HB367_08880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB367_08885	COG3139	Protein of unknown function (DUF1315)
HB367_08890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB367_08895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB367_08905	COG0494	nUDIX hydrolase
HB367_08915	COG0642	Histidine kinase
HB367_08920	COG0745	RESPONSE REGULATOR receiver
HB367_08940	COG1720	tRNA m6t6A37 methyltransferase activity
HB367_08950	COG0384	phenazine biosynthesis protein PhzF
HB367_08955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_08965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB367_08975	COG4598	ABC transporter
HB367_08980	COG4160	amino acid transport
HB367_08985	COG4215	(ABC) transporter
HB367_09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_09050	COG3179	chitinase
HB367_09100	COG1598	PFAM Uncharacterised protein family UPF0150
HB367_09195	COG5410	chromosome segregation
HB367_09215	COG2357	RelA SpoT domain protein
HB367_09295	COG0305	Participates in initiation and elongation during chromosome replication
HB367_09355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_09420	COG0564	pseudouridine synthase activity
HB367_09430	COG0358	DNA primase activity
HB367_09445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB367_09475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB367_09505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB367_09515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB367_09515	COG0352	thiamine-phosphate diphosphorylase activity
HB367_09515	COG0351	phosphomethylpyrimidine kinase
HB367_09520	COG1652	LysM domain
HB367_09545	COG1399	metal-binding, possibly nucleic acid-binding protein
HB367_09550	COG3101	peptidyl-lysine hydroxylation
HB367_09555	COG0009	L-threonylcarbamoyladenylate synthase
HB367_09560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB367_09565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB367_09580	COG4106	trans-aconitate 2-methyltransferase activity
HB367_09595	COG0596	Alpha beta hydrolase
HB367_09595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB367_09595	COG2226	methyltransferase
HB367_09600	COG1877	trehalose-phosphatase activity
HB367_09605	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB367_09610	COG2223	nitrite transmembrane transporter activity
HB367_09630	COG1196	nuclear chromosome segregation
HB367_09640	COG0730	response to heat
HB367_09655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB367_09665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB367_09715	COG0489	protein tyrosine kinase activity
HB367_09725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB367_09725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB367_09755	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB367_09760	COG2081	HI0933 family
HB367_09770	COG0668	transmembrane transport
HB367_09790	COG0583	DNA-binding transcription factor activity
HB367_09810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB367_09815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB367_09845	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB367_09880	COG2205	protein histidine kinase activity
HB367_09885	COG0745	RESPONSE REGULATOR receiver
HB367_09905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB367_09920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_09935	COG0583	DNA-binding transcription factor activity
HB367_09965	COG0583	DNA-binding transcription factor activity
HB367_09980	COG0583	DNA-binding transcription factor activity
HB367_09985	COG1053	succinate dehydrogenase
HB367_09995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB367_10000	COG2814	Major facilitator Superfamily
HB367_10005	COG1960	acyl-CoA dehydrogenase activity
HB367_10010	COG0583	DNA-binding transcription factor activity
HB367_10015	COG1063	alcohol dehydrogenase
HB367_10045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB367_10050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB367_10055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB367_10070	COG3667	copper resistance
HB367_10075	COG2132	Multicopper oxidase
HB367_10085	COG0561	phosphatase activity
HB367_10090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB367_10100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB367_10115	COG1214	PFAM Peptidase M22, glycoprotease
HB367_10140	COG3328	transposase activity
HB367_10150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB367_10160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB367_10165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB367_10170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB367_10230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB367_10240	COG1846	Transcriptional regulator
HB367_10245	COG1764	response to oxidative stress
HB367_10285	COG0037	tRNA processing
HB367_10295	COG0248	Ppx GppA phosphatase
HB367_10325	COG0072	phenylalanine-tRNA ligase activity
HB367_10365	COG1238	metal cluster binding
HB367_10370	COG0625	glutathione transferase activity
HB367_10385	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_10390	COG3028	Belongs to the UPF0307 family
HB367_10395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB367_10415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB367_10420	COG0617	tRNA 3'-terminal CCA addition
HB367_10425	COG1555	photosystem II stabilization
HB367_10430	COG3956	TIGRFAM MazG family protein
HB367_10440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB367_10460	COG5002	protein histidine kinase activity
HB367_10460	COG2205	protein histidine kinase activity
HB367_10460	COG0784	Response regulator, receiver
HB367_10465	COG1024	Enoyl-CoA hydratase
HB367_10470	COG2084	Dehydrogenase
HB367_10475	COG3622	Belongs to the hyi family
HB367_10505	COG0697	spore germination
HB367_10515	COG2814	Major facilitator Superfamily
HB367_10520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB367_10530	COG0583	DNA-binding transcription factor activity
HB367_10540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB367_10550	COG0084	hydrolase, TatD family'
HB367_10565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB367_10590	COG2130	NADP-dependent
HB367_10595	COG1309	transcriptional regulator
HB367_10605	COG1902	pentaerythritol trinitrate reductase activity
HB367_10615	COG1979	alcohol dehydrogenase
HB367_10630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB367_10645	COG0604	alcohol dehydrogenase
HB367_10645	COG3321	synthase
HB367_10650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB367_10655	COG0583	DNA-binding transcription factor activity
HB367_10660	COG4221	oxidoreductase activity
HB367_10700	COG2826	transposase and inactivated derivatives, IS30 family
HB367_10725	COG0440	acetolactate synthase activity
HB367_10730	COG0028	Belongs to the TPP enzyme family
HB367_10755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_10760	COG1136	(ABC) transporter
HB367_10760	COG0577	efflux transmembrane transporter activity
HB367_10765	COG1538	Outer membrane efflux protein
HB367_10780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB367_10785	COG1162	GTPase activity
HB367_10795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB367_10835	COG1426	Protein conserved in bacteria
HB367_10870	COG0793	Belongs to the peptidase S41A family
HB367_10885	COG2267	carboxylic ester hydrolase activity
HB367_10895	COG1012	belongs to the aldehyde dehydrogenase family
HB367_10900	COG3265	gluconokinase activity
HB367_10910	COG0800	Aldolase
HB367_10920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB367_10925	COG0280	phosphate acetyltransferase
HB367_10925	COG0857	belongs to the CobB CobQ family
HB367_10930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB367_10930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB367_10950	COG0740	serine-type endopeptidase activity
HB367_10960	COG4774	siderophore transport
HB367_10970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB367_10980	COG2813	Specifically methylates the guanine in position
HB367_10980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB367_11085	COG0788	formyltetrahydrofolate deformylase activity
HB367_11110	COG4651	solute:proton antiporter activity
HB367_11110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB367_11135	COG0724	RNA recognition motif
HB367_11140	COG0210	DNA helicase
HB367_11165	COG1733	regulation of RNA biosynthetic process
HB367_11175	COG2900	Belongs to the SlyX family
HB367_11185	COG1280	lysine exporter protein (LysE YggA)
HB367_11190	COG1560	Kdo2-lipid A biosynthetic process
HB367_11200	COG1301	dicarboxylic acid transport
HB367_11255	COG0473	3-isopropylmalate dehydrogenase activity
HB367_11320	COG0583	DNA-binding transcription factor activity
HB367_11330	COG0625	glutathione transferase activity
HB367_11335	COG2378	regulation of single-species biofilm formation
HB367_11340	COG0546	phosphoglycolate phosphatase activity
HB367_11355	COG1530	ribonuclease E activity
HB367_11360	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_11375	COG0583	DNA-binding transcription factor activity
HB367_11380	COG4221	oxidoreductase activity
HB367_11385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB367_11410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB367_11450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB367_11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB367_11470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB367_11480	COG0644	oxidoreductase
HB367_11480	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB367_11490	COG0425	Belongs to the sulfur carrier protein TusA family
HB367_11495	COG4535	Mg2 and Co2 transporter CorC
HB367_11505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB367_11525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB367_11530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB367_11530	COG0475	glutathione-regulated potassium exporter activity
HB367_11545	COG0484	heat shock protein binding
HB367_11550	COG0789	Transcriptional regulator
HB367_11555	COG0598	Magnesium transport protein CorA
HB367_11575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB367_11580	COG1074	ATP-dependent DNA helicase activity
HB367_11585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB367_11605	COG2226	methyltransferase
HB367_11620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_11625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB367_11640	COG2111	Na H antiporter
HB367_11640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB367_11645	COG1006	Multisubunit Na H antiporter MnhC subunit
HB367_11650	COG0651	ATP synthesis coupled electron transport
HB367_11660	COG2212	antiporter activity
HB367_11680	COG0195	Participates in both transcription termination and antitermination
HB367_11730	COG0237	dephospho-CoA kinase activity
HB367_11740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB367_11755	COG0497	DNA recombination
HB367_11765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB367_11795	COG2169	Transcriptional regulator
HB367_11795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB367_11800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB367_11860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB367_11875	COG0326	Molecular chaperone. Has ATPase activity
HB367_11890	COG2056	Na+-H+ antiporter family
HB367_11895	COG0596	Alpha beta hydrolase
HB367_11910	COG3328	transposase activity
HB367_11995	COG0546	phosphoglycolate phosphatase activity
HB367_12000	COG1716	ATPase activity
HB367_12045	COG0181	hydroxymethylbilane synthase activity
HB367_12055	COG3275	phosphorelay sensor kinase activity
HB367_12075	COG1538	Outer membrane efflux protein
HB367_12080	COG0697	spore germination
HB367_12105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB367_12110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB367_12115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB367_12120	COG0772	Belongs to the SEDS family
HB367_12145	COG4974	Belongs to the 'phage' integrase family
HB367_12150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB367_12160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB367_12170	COG2197	response regulator
HB367_12185	COG0793	Belongs to the peptidase S41A family
HB367_12190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB367_12195	COG0795	lipopolysaccharide-transporting ATPase activity
HB367_12235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB367_12235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB367_12245	COG0004	ammonium transporteR
HB367_12250	COG0347	Belongs to the P(II) protein family
HB367_12260	COG0606	chelatase, subunit chli
HB367_12285	COG1061	Type III restriction enzyme res subunit
HB367_12300	COG0659	secondary active sulfate transmembrane transporter activity
HB367_12305	COG0589	response to stress
HB367_12345	COG0606	chelatase, subunit chli
HB367_12350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_12355	COG0235	Class ii aldolase
HB367_12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_12390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB367_12405	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_12415	COG0477	Major facilitator Superfamily
HB367_12420	COG2860	membrane
HB367_12425	COG3012	SEC-C Motif Domain Protein
HB367_12430	COG1253	flavin adenine dinucleotide binding
HB367_12440	COG2814	Major facilitator Superfamily
HB367_12450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB367_12485	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB367_12495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB367_12530	COG1309	transcriptional regulator
HB367_12565	COG0758	DNA mediated transformation
HB367_12575	COG0697	spore germination
HB367_12580	COG1309	transcriptional regulator
HB367_12595	COG0386	Belongs to the glutathione peroxidase family
HB367_12665	COG1121	(ABC) transporter
HB367_12670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB367_12675	COG1280	lysine exporter protein (LysE YggA)
HB367_12680	COG2837	iron assimilation
HB367_12690	COG0281	malic enzyme
HB367_12735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB367_12735	COG0519	Catalyzes the synthesis of GMP from XMP
HB367_12740	COG4399	Belongs to the UPF0754 family
HB367_12745	COG2259	Doxx family
HB367_12750	COG0586	Pfam SNARE associated Golgi protein
HB367_12765	COG1192	Involved in chromosome partitioning
HB367_12775	COG0271	Belongs to the BolA IbaG family
HB367_12795	COG1024	Enoyl-CoA hydratase
HB367_12800	COG1024	Enoyl-CoA hydratase
HB367_12805	COG1960	acyl-CoA dehydrogenase activity
HB367_12810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB367_12830	COG1113	amino acid transport
HB367_12835	COG1113	amino acid transport
HB367_12840	COG0251	oxidation-reduction process
HB367_12880	COG0564	pseudouridine synthase activity
HB367_12915	COG1051	belongs to the nudix hydrolase family
HB367_12935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB367_12950	COG1802	Transcriptional regulator
HB367_12960	COG1448	Aminotransferase
HB367_12965	COG0277	FAD linked oxidase domain protein
HB367_12975	COG2186	Transcriptional regulator
HB367_12985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_12990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB367_13005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB367_13010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB367_13015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB367_13030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB367_13070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB367_13075	COG1596	polysaccharide export
HB367_13100	COG0728	peptidoglycan biosynthetic process
HB367_13105	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB367_13165	COG0546	phosphoglycolate phosphatase activity
HB367_13170	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_13190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB367_13195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB367_13200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB367_13205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB367_13210	COG1116	anion transmembrane transporter activity
HB367_13215	COG1309	transcriptional regulator
HB367_13220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB367_13230	COG0196	riboflavin kinase activity
HB367_13235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB367_13245	COG1047	Peptidyl-prolyl cis-trans
HB367_13285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB367_13340	COG2951	lytic endotransglycosylase activity
HB367_13345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB367_13360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB367_13370	COG3328	transposase activity
HB367_13380	COG0671	phosphoesterase, PA-phosphatase related
HB367_13385	COG0861	Integral membrane protein TerC family
HB367_13395	COG0754	glutathionylspermidine amidase activity
HB367_13405	COG0402	S-adenosylhomocysteine deaminase activity
HB367_13420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB367_13425	COG1230	cation diffusion facilitator family transporter
HB367_13440	COG0706	membrane insertase activity
HB367_13465	COG0592	DNA-directed DNA polymerase activity
HB367_13475	COG0187	DNA topoisomerase II activity
HB367_13485	COG0586	Pfam SNARE associated Golgi protein
HB367_13490	COG0488	(ABC) transporter
HB367_13515	COG0596	Alpha beta hydrolase
HB367_13520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB367_13525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB367_13565	COG0733	neurotransmitter:sodium symporter activity
HB367_13600	COG0583	DNA-binding transcription factor activity
HB367_13605	COG2233	PERMEase
HB367_13620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_13655	COG2814	Major facilitator Superfamily
HB367_13660	COG0656	L-ascorbic acid biosynthetic process
HB367_13665	COG0583	DNA-binding transcription factor activity
HB367_13680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_13685	COG1064	alcohol dehydrogenase
HB367_13690	COG2818	Glycosylase
HB367_13705	COG1194	a g-specific adenine glycosylase
HB367_13725	COG2983	Belongs to the UPF0260 family
HB367_13730	COG2133	pyrroloquinoline quinone binding
HB367_13735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB367_13740	COG2116	formate transmembrane transporter activity
HB367_13760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_13765	COG1335	isochorismatase
HB367_13770	COG0385	Bile acid
HB367_13775	COG0534	Mate efflux family protein
HB367_13780	COG1683	Conserved Protein
HB367_13800	COG0625	glutathione transferase activity
HB367_13810	COG1113	amino acid transport
HB367_13820	COG0523	cobalamin synthesis protein
HB367_13830	COG2188	Transcriptional regulator
HB367_13860	COG0010	Belongs to the arginase family
HB367_13875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB367_13880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB367_13890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB367_13895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB367_13985	COG0436	Aminotransferase
HB367_13990	COG2733	membrane
HB367_14005	COG2918	glutathione biosynthetic process
HB367_14075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_14090	COG3501	Rhs element vgr protein
HB367_14150	COG3150	esterase
HB367_14160	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_14165	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB367_14175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_14190	COG2233	PERMEase
HB367_14195	COG2351	hydroxyisourate hydrolase activity
HB367_14230	COG3706	GGDEF domain
HB367_14245	COG1393	Belongs to the ArsC family
HB367_14250	COG0708	Exodeoxyribonuclease III
HB367_14275	COG0189	ligase activity
HB367_14295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB367_14305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB367_14320	COG4942	peptidase
HB367_14330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB367_14340	COG2119	membrane
HB367_14345	COG4774	siderophore transport
HB367_14350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_14350	COG0426	domain, Protein
HB367_14375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB367_14395	COG1902	pentaerythritol trinitrate reductase activity
HB367_14400	COG1519	Transferase
HB367_14405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB367_14410	COG0668	transmembrane transport
HB367_14420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB367_14425	COG1335	isochorismatase
HB367_14430	COG1522	sequence-specific DNA binding
HB367_14455	COG0784	Response regulator, receiver
HB367_14455	COG2198	Histidine kinase
HB367_14455	COG2205	protein histidine kinase activity
HB367_14460	COG3162	membrane
HB367_14465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB367_14475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB367_14485	COG3706	GGDEF domain
HB367_14490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB367_14495	COG1309	transcriptional regulator
HB367_14515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB367_14515	COG0352	thiamine-phosphate diphosphorylase activity
HB367_14515	COG0351	phosphomethylpyrimidine kinase
HB367_14525	COG2814	Major facilitator Superfamily
HB367_14540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB367_14550	COG1113	amino acid transport
HB367_14560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB367_14565	COG1012	belongs to the aldehyde dehydrogenase family
HB367_14575	COG1335	isochorismatase
HB367_14605	COG2814	Major facilitator Superfamily
HB367_14610	COG0583	DNA-binding transcription factor activity
HB367_14665	COG0667	Aldo Keto reductase
HB367_14685	COG1129	ABC transporter
HB367_14695	COG2207	Transcriptional regulator
HB367_14750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB367_14765	COG2329	Antibiotic biosynthesis monooxygenase
HB367_14780	COG1132	(ABC) transporter
HB367_14800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB367_14830	COG0427	acetyl-CoA hydrolase
HB367_14845	COG0745	RESPONSE REGULATOR receiver
HB367_14855	COG0659	secondary active sulfate transmembrane transporter activity
HB367_14860	COG4221	oxidoreductase activity
HB367_14870	COG0488	(ABC) transporter
HB367_14935	COG0833	amino acid
HB367_14980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB367_14985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB367_15000	COG2226	methyltransferase
HB367_15050	COG0070	glutamate synthase
HB367_15050	COG0067	glutamate synthase
HB367_15050	COG0069	glutamate synthase activity
HB367_15055	COG0493	'glutamate synthase
HB367_15065	COG1704	LemA family
HB367_15070	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB367_15090	COG3307	-O-antigen
HB367_15110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB367_15125	COG0194	GDP metabolic process
HB367_15175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB367_15195	COG5380	lipid catabolic process
HB367_15200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB367_15225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB367_15230	COG0277	FAD linked oxidase domain protein
HB367_15240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB367_15245	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB367_15260	COG1289	transmembrane transporter activity
HB367_15270	COG0628	permease
HB367_15275	COG1192	Involved in chromosome partitioning
HB367_15305	COG0833	amino acid
HB367_15310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB367_15315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB367_15325	COG1012	belongs to the aldehyde dehydrogenase family
HB367_15365	COG0583	DNA-binding transcription factor activity
HB367_15425	COG0517	IMP dehydrogenase activity
HB367_15430	COG1983	PspC domain protein
HB367_15440	COG1960	acyl-CoA dehydrogenase activity
HB367_15455	COG0408	coproporphyrinogen oxidase activity
HB367_15475	COG0513	Belongs to the DEAD box helicase family
HB367_15485	COG1127	ABC transporter
HB367_15490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB367_15500	COG2854	intermembrane phospholipid transfer
HB367_15510	COG0598	Magnesium transport protein CorA
HB367_15520	COG0494	nUDIX hydrolase
HB367_15525	COG1040	competence protein
HB367_15530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB367_15550	COG1946	Acyl-CoA thioesterase
HB367_15555	COG1301	dicarboxylic acid transport
HB367_15570	COG1959	2 iron, 2 sulfur cluster binding
HB367_15575	COG1017	nitric oxide dioxygenase activity
HB367_15575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_15580	COG0433	COG0433 Predicted ATPase
HB367_15585	COG0626	cystathionine gamma-synthase activity
HB367_15740	COG1960	acyl-CoA dehydrogenase activity
HB367_15745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB367_15775	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB367_15780	COG0339	signal peptide processing
HB367_15785	COG0557	exoribonuclease II activity
HB367_15830	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB367_15835	COG2169	Transcriptional regulator
HB367_15840	COG0697	spore germination
HB367_15845	COG1295	ribonuclease BN
HB367_15880	COG1702	phosphate starvation-inducible protein PhoH
HB367_15890	COG1196	nuclear chromosome segregation
HB367_15890	COG0741	lytic transglycosylase activity
HB367_15890	COG0739	heme binding
HB367_15920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB367_15925	COG1183	phosphatidylcholine synthase activity
HB367_15970	COG1960	acyl-CoA dehydrogenase activity
HB367_15990	COG2969	positive regulation of protein catabolic process
HB367_16000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB367_16010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB367_16015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB367_16020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB367_16040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB367_16050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB367_16055	COG1408	metallophosphoesterase
HB367_16065	COG2199	diguanylate cyclase activity
HB367_16125	COG1607	acyl-coa hydrolase
HB367_16155	COG2350	Protein conserved in bacteria
HB367_16165	COG0613	PHP domain protein
HB367_16170	COG3781	membrane
HB367_16180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB367_16185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB367_16195	COG1862	Preprotein translocase
HB367_16230	COG2205	protein histidine kinase activity
HB367_16235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB367_16255	COG0726	polysaccharide deacetylase
HB367_16260	COG0463	Glycosyl transferase, family 2
HB367_16265	COG0438	transferase activity, transferring glycosyl groups
HB367_16280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB367_16290	COG2826	transposase and inactivated derivatives, IS30 family
HB367_16300	COG2826	transposase and inactivated derivatives, IS30 family
HB367_16345	COG1960	acyl-CoA dehydrogenase activity
HB367_16350	COG1960	acyl-CoA dehydrogenase activity
HB367_16360	COG2205	protein histidine kinase activity
HB367_16365	COG0745	RESPONSE REGULATOR receiver
HB367_16370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB367_16385	COG0584	glycerophosphoryl diester phosphodiesterase
HB367_16390	COG2096	Adenosyltransferase
HB367_16395	COG4206	TonB-dependent receptor
HB367_16440	COG0285	dihydrofolate synthase activity
HB367_16460	COG0450	alkyl hydroperoxide reductase
HB367_16475	COG0477	Major facilitator Superfamily
HB367_16480	COG1272	protein, Hemolysin III
HB367_16510	COG0183	Belongs to the thiolase family
HB367_16515	COG2207	Transcriptional regulator
HB367_16535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_16555	COG0183	Belongs to the thiolase family
HB367_16565	COG2885	chlorophyll binding
HB367_16565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB367_16575	COG1690	Belongs to the RtcB family
HB367_16580	COG0833	amino acid
HB367_16590	COG2233	PERMEase
HB367_16620	COG2094	Belongs to the DNA glycosylase MPG family
HB367_16625	COG4772	TonB-dependent receptor
HB367_16630	COG1902	pentaerythritol trinitrate reductase activity
HB367_16635	COG0679	Auxin Efflux Carrier
HB367_16645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB367_16650	COG0354	folic acid binding
HB367_16660	COG3189	MarR family transcriptional regulator
HB367_16665	COG2824	Alkylphosphonate utilization operon protein PhnA
HB367_16670	COG3422	double-strand break repair
HB367_16710	COG0840	transmembrane signaling receptor activity
HB367_16730	COG5510	response to toxic substance
HB367_16740	COG2832	Protein of unknown function (DUF454)
HB367_16745	COG1376	ErfK ybiS ycfS ynhG family protein
HB367_16785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB367_16795	COG1289	transmembrane transporter activity
HB367_16800	COG2814	Major facilitator Superfamily
HB367_16820	COG1115	amino acid carrier protein
HB367_16825	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB367_16830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB367_16835	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB367_16840	COG3590	peptidase
HB367_16865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB367_16875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB367_16880	COG1077	Cell shape determining protein MreB Mrl
HB367_16885	COG1792	Involved in formation and maintenance of cell shape
HB367_16890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB367_16895	COG0424	maF-like protein
HB367_16900	COG1530	ribonuclease E activity
HB367_16910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_16920	COG0560	Phosphoserine phosphatase
HB367_16930	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB367_16955	COG2207	Transcriptional regulator
HB367_17000	COG1113	amino acid transport
HB367_17005	COG2828	Protein conserved in bacteria
HB367_17010	COG0142	geranyltranstransferase activity
HB367_17015	COG2315	Protein conserved in bacteria
HB367_17030	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB367_17050	COG2194	sulfuric ester hydrolase activity
HB367_17055	COG0745	RESPONSE REGULATOR receiver
HB367_17060	COG0642	Histidine kinase
HB367_17070	COG0004	ammonium transporteR
HB367_17075	COG0583	DNA-binding transcription factor activity
HB367_17090	COG2226	methyltransferase
HB367_17095	COG0525	valine-tRNA ligase activity
HB367_17105	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_17115	COG0393	Putative heavy-metal-binding
HB367_17120	COG0393	Putative heavy-metal-binding
HB367_17125	COG1538	Outer membrane efflux protein
HB367_17135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_17140	COG0671	phosphoesterase, PA-phosphatase related
HB367_17170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB367_17185	COG1648	precorrin-2 dehydrogenase activity
HB367_17185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB367_17190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB367_17205	COG0531	amino acid
HB367_17220	COG0321	lipoyl(octanoyl) transferase activity
HB367_17225	COG2921	Belongs to the UPF0250 family
HB367_17260	COG2009	succinate dehydrogenase
HB367_17265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB367_17270	COG1053	succinate dehydrogenase
HB367_17275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB367_17300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB367_17320	COG2354	Protein conserved in bacteria
HB367_17325	COG2321	neutral zinc metallopeptidase
HB367_17345	COG2843	Capsule synthesis protein
HB367_17360	COG0589	response to stress
HB367_17370	COG0251	oxidation-reduction process
HB367_17375	COG1309	transcriptional regulator
HB367_17390	COG0505	Belongs to the CarA family
HB367_17415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB367_17420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB367_17470	COG0477	Major facilitator Superfamily
HB367_17475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB367_17490	COG1597	lipid kinase activity
HB367_17495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB367_17520	COG0584	glycerophosphoryl diester phosphodiesterase
HB367_17540	COG0741	lytic transglycosylase activity
HB367_17560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB367_17570	COG0582	viral genome integration into host DNA
HB367_17595	COG2217	Heavy metal translocating P-type atpase
HB367_17600	COG2205	protein histidine kinase activity
HB367_17615	COG2132	Multicopper oxidase
HB367_17640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_17655	COG0778	Nitroreductase
HB367_17670	COG1929	Belongs to the glycerate kinase type-1 family
HB367_17675	COG0243	molybdopterin cofactor binding
HB367_17680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB367_17685	COG3339	Conserved Protein
HB367_17695	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB367_17715	COG1115	amino acid carrier protein
HB367_17720	COG1113	amino acid transport
HB367_17730	COG0019	diaminopimelate decarboxylase activity
HB367_17740	COG2267	carboxylic ester hydrolase activity
HB367_17745	COG1280	lysine exporter protein (LysE YggA)
HB367_17750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB367_17780	COG0463	Glycosyl transferase, family 2
HB367_17800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_17835	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB367_17840	COG1136	(ABC) transporter
HB367_17845	COG2333	competence protein COMEC
HB367_17845	COG0658	competence protein
HB367_17855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB367_17855	COG0616	signal peptide processing
HB367_17860	COG0596	Alpha beta hydrolase
HB367_17865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB367_17875	COG0628	permease
HB367_17910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB367_17930	COG0823	Involved in the tonB-independent uptake of proteins
HB367_17950	COG0824	Thioesterase
HB367_17955	COG1473	amidohydrolase
HB367_17975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB367_17975	COG0047	phosphoribosylformylglycinamidine synthase activity
HB367_17980	COG2814	Major facilitator Superfamily
HB367_17990	COG1024	Enoyl-CoA hydratase
HB367_17995	COG1051	belongs to the nudix hydrolase family
HB367_17995	COG1056	cytidyltransferase-related domain
HB367_18005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB367_18020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB367_18035	COG4625	pathogenesis
HB367_18040	COG0583	DNA-binding transcription factor activity
HB367_18045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB367_18050	COG4208	sulfate ABC transporter
HB367_18055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB367_18065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB367_18070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB367_18075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB367_18095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB367_18110	COG0681	Belongs to the peptidase S26 family
HB367_18125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB367_18135	COG1381	Involved in DNA repair and RecF pathway recombination
HB367_18140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB367_18150	COG4221	oxidoreductase activity
HB367_18180	COG0443	Heat shock 70 kDa protein
HB367_18190	COG0436	Aminotransferase
HB367_18210	COG0556	nucleotide-excision repair
HB367_18265	COG2070	2-Nitropropane dioxygenase
HB367_18295	COG1215	transferase activity, transferring glycosyl groups
HB367_18310	COG0415	Belongs to the DNA photolyase family
HB367_18320	COG1252	NADH dehydrogenase
HB367_18325	COG1686	Belongs to the peptidase S11 family
HB367_18340	COG1187	pseudouridine synthase activity
HB367_18365	COG0477	Major facilitator Superfamily
HB367_18370	COG0583	DNA-binding transcription factor activity
HB367_18385	COG0612	Peptidase, M16
HB367_18410	COG0352	thiamine-phosphate diphosphorylase activity
HB367_18425	COG0564	pseudouridine synthase activity
HB367_18430	COG2826	transposase and inactivated derivatives, IS30 family
HB367_18455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_18470	COG1309	transcriptional regulator
HB367_18480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB367_18485	COG0076	glutamate decarboxylase activity
HB367_18495	COG1522	sequence-specific DNA binding
HB367_18500	COG3961	Belongs to the TPP enzyme family
HB367_18505	COG1113	amino acid transport
HB367_18510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB367_18515	COG0573	inorganic phosphate transmembrane transporter activity
HB367_18525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB367_18530	COG0616	signal peptide processing
HB367_18565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB367_18570	COG1686	Belongs to the peptidase S11 family
HB367_18595	COG0583	DNA-binding transcription factor activity
HB367_18600	COG1067	ATP-dependent peptidase activity
HB367_18625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HB367_18645	COG1966	Carbon starvation protein
HB367_18650	COG2879	small protein
HB367_18675	COG2826	transposase and inactivated derivatives, IS30 family
HB367_18695	COG1741	Belongs to the pirin family
HB367_18705	COG2964	Protein conserved in bacteria
HB367_18720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_18725	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB367_18730	COG4605	iron ion homeostasis
HB367_18735	COG4604	ABC transporter, ATP-binding protein
HB367_18740	COG4607	ABC-type enterochelin transport system periplasmic component
HB367_18745	COG4774	siderophore transport
HB367_18755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_18760	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB367_18765	COG3433	isochorismatase activity
HB367_18765	COG1535	isochorismatase
HB367_18780	COG1132	(ABC) transporter
HB367_18785	COG5265	(ABC) transporter
HB367_18790	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB367_18810	COG1169	isochorismate synthase
HB367_18825	COG3739	integral membrane protein
HB367_18855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB367_18885	COG0308	aminopeptidase N
HB367_18890	COG0512	Glutamine amidotransferase of anthranilate synthase
HB367_18900	COG3104	oligopeptide transport
HB367_18905	COG0174	glutamine synthetase
HB367_18915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB367_18950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB367_18955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB367_18960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB367_18980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB367_18985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB367_18990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB367_19005	COG1960	acyl-CoA dehydrogenase activity
HB367_19010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB367_19015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB367_19025	COG2223	nitrite transmembrane transporter activity
HB367_19035	COG0024	Methionine aminopeptidase
HB367_19040	COG0052	Belongs to the universal ribosomal protein uS2 family
HB367_19055	COG2207	Transcriptional regulator
HB367_19065	COG2826	transposase and inactivated derivatives, IS30 family
HB367_19090	COG2951	lytic endotransglycosylase activity
HB367_19095	COG0772	Belongs to the SEDS family
HB367_19110	COG0842	Transport permease protein
HB367_19115	COG1131	(ABC) transporter
HB367_19135	COG3173	Aminoglycoside phosphotransferase
HB367_19155	COG0482	sulfurtransferase activity
HB367_19280	COG1192	Involved in chromosome partitioning
HB367_19305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_19325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB367_19330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB367_19375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB367_19425	COG2826	transposase and inactivated derivatives, IS30 family
HB367_19450	COG1324	tolerance protein
HB367_19455	COG0673	inositol 2-dehydrogenase activity
HB367_19475	COG2826	transposase and inactivated derivatives, IS30 family
HB367_19515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB367_19565	COG1192	Involved in chromosome partitioning
HB367_19575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB367_19620	COG0739	heme binding
HB367_19845	COG0501	Belongs to the peptidase M48B family
HB367_19880	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB367_19930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_20000	COG3561	AntA/AntB antirepressor
HB367_20055	COG3179	chitinase
HB367_20065	COG0582	viral genome integration into host DNA
HB367_20070	COG3617	BRO family, N-terminal domain
HB367_20110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_20165	COG0305	Participates in initiation and elongation during chromosome replication
HB367_20280	COG5410	chromosome segregation
HB367_20435	COG2832	Protein of unknown function (DUF454)
HB367_20495	COG4683	PFAM Phage derived protein Gp49-like (DUF891)