locus-tag class description EA719_000010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EA719_000020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EA719_000030 ENOG4105DQR SNARE associated Golgi EA719_000035 ENOG4105C5H ABC transporter EA719_000040 ENOG4108821 RND type efflux pump EA719_000045 ENOG4108821 RND type efflux pump EA719_000050 ENOG4108821 RND type efflux pump EA719_000060 ENOG4105D74 hydrolase EA719_000065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EA719_000070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EA719_000115 ENOG4105C8J )-transporter EA719_000125 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EA719_000155 ENOG4105C2W permease EA719_000165 ENOG4108IG5 Transcriptional regulator EA719_000170 ENOG4105DJY efflux transporter, rnd family, mfp subunit EA719_000205 ENOG4105F27 Major Facilitator EA719_000210 ENOG4105CV8 reductase EA719_000215 ENOG4105HEI LysR family (Transcriptional regulator EA719_000235 ENOG4105DQ4 alcohol dehydrogenase EA719_000240 ENOG4108R3E Dna-3-methyladenine glycosylase i EA719_000255 ENOG4105CEN a g-specific adenine glycosylase EA719_000275 ENOG4108ZZ3 UPF0260 protein EA719_000285 ENOG4105D1H recombination factor protein RarA EA719_000290 ENOG4105S64 Formate nitrite transporter EA719_000310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EA719_000315 ENOG4108RWI nicotinamidase EA719_000320 ENOG4105C09 Bile acid EA719_000325 ENOG4107QI1 Mate efflux family protein EA719_000330 ENOG4105EWC Purine nucleoside phosphorylase EA719_000350 ENOG4108RXX maleylacetoacetate isomerase EA719_000360 ENOG4105C85 amino acid EA719_000370 ENOG4105CKI cobalamin synthesis protein EA719_000380 ENOG4105CZE histidine utilization repressor EA719_000385 ENOG41090B9 response to stress EA719_000400 ENOG4105C85 amino acid EA719_000410 ENOG41088SP formiminoglutamate hydrolase EA719_000425 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EA719_000430 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EA719_000440 ENOG4108ZAI phosphatidylglycerophosphatase a EA719_000445 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EA719_000460 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EA719_000500 ENOG4105KHC sulfurtransferase EA719_000530 ENOG4105BZU Histidine kinase EA719_000535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EA719_000550 ENOG4107QJQ Mate efflux family protein EA719_000555 ENOG4105CHM Aminotransferase EA719_000560 ENOG4106BRA Membrane EA719_000575 ENOG4105D9M gamma-glutamylcysteine synthetase EA719_000585 ENOG4105CS6 Rhs element vgr protein EA719_000590 ENOG4105K4H Nlp p60 protein EA719_000610 ENOG4105IPS esterase EA719_000615 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EA719_000620 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EA719_000625 ENOG4108Z2U ureidoglycolate hydrolase EA719_000635 ENOG41061H0 Monooxygenase EA719_000650 ENOG41084YZ Hydrolase EA719_000680 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EA719_000685 ENOG4105BZU Histidine kinase EA719_000700 ENOG4105KUZ arsenate reductase EA719_000705 ENOG4105CGK Exodeoxyribonuclease III EA719_000725 ENOG4105D7Z glutathione synthase EA719_000745 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EA719_000750 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EA719_000755 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EA719_000770 ENOG41063SB peptidase EA719_000775 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EA719_000780 ENOG4107QSN dihydrolipoamide acetyltransferase EA719_000820 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EA719_000835 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EA719_000855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EA719_000860 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EA719_000870 ENOG4105D64 Mechanosensitive ion channel EA719_000880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EA719_000885 ENOG4108W2Y isochorismatase EA719_000895 ENOG4105D5G Transposase EA719_000900 ENOG4105FBW Monooxygenase EA719_000905 ENOG4108UZX fmn reductase EA719_000920 ENOG4105BZU Histidine kinase EA719_000925 ENOG41062QD Membrane EA719_000930 ENOG4107QN1 sodium solute EA719_000940 ENOG4105C94 Transporter EA719_000950 ENOG4105BZU Histidine kinase EA719_000960 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EA719_000965 ENOG4108WUH Transcriptional regulator, TetR family EA719_000970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EA719_000980 ENOG4105RA2 Membrane EA719_000985 ENOG4105DWF phosphomethylpyrimidine kinase EA719_000995 ENOG4107RDB Major Facilitator EA719_001000 ENOG4108UUM single-stranded DNA-binding protein EA719_001010 ENOG4108UMN azlc family EA719_001020 ENOG4105C85 amino acid EA719_001030 ENOG4108JPW Aminotransferase EA719_001035 ENOG4105C26 Dehydrogenase EA719_001045 ENOG4105CHJ isochorismatase hydrolase EA719_001050 ENOG4105EUB pirin domain protein EA719_001075 ENOG4105D94 Major Facilitator Superfamily EA719_001080 ENOG4106NZI LysR family Transcriptional regulator EA719_001100 ENOG4105CPC Aldo Keto reductase EA719_001105 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) EA719_001135 ENOG4105KVH Transcriptional regulator EA719_001145 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EA719_001210 ENOG4105CUV Homoserine Kinase EA719_001225 ENOG41061CK Antibiotic biosynthesis monooxygenase EA719_001255 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EA719_001285 ENOG4105CYC Transferase EA719_001295 ENOG4105E0F Histidine kinase EA719_001300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EA719_001310 ENOG4105CHH sulfate transporter EA719_001315 ENOG4105PDP Short chain dehydrogenase EA719_001325 ENOG4105C5H ABC transporter EA719_001410 ENOG4108IQI permease EA719_001435 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EA719_001450 ENOG4105CJN penicillin-binding protein EA719_001455 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EA719_001460 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EA719_001475 ENOG4105DHI Methyltransferase EA719_001480 ENOG4108JQC penicillin-binding protein 1A EA719_001505 ENOG4105E4G Type IV pilus EA719_001525 ENOG4105CBC glutamate synthase EA719_001530 ENOG4105BZ8 glutamate synthase EA719_001540 ENOG4108V0P LemA family EA719_001545 ENOG4105HA9 of methanol dehydrogenase type EA719_001565 ENOG4108YSG O-Antigen polymerase EA719_001570 ENOG4108UQY Iron-storage protein EA719_001580 ENOG4105KME endoribonuclease L-psp EA719_001585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EA719_001600 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EA719_001650 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EA719_001665 ENOG4107IFA Lipase (EC 3.1.1.3) EA719_001670 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) EA719_001675 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EA719_001700 ENOG4108JQ1 Dehydrogenase EA719_001705 ENOG4105CQB FAD linked oxidase domain protein EA719_001715 ENOG4105VRH Antibiotic biosynthesis monooxygenase EA719_001720 ENOG4105NF4 modulator of drug activity EA719_001730 ENOG4107QF7 multi-drug EA719_001735 ENOG4105EM2 membrane EA719_001740 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EA719_001745 ENOG4105IPI Membrane EA719_001750 ENOG4107SKI cobyrinic Acid a,c-diamide synthase EA719_001780 ENOG4108IQI permease EA719_001790 ENOG4105C8Y Acetylornithine aminotransferase EA719_001800 ENOG4105C26 Dehydrogenase EA719_001825 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EA719_001885 ENOG4105W87 Cbs domain EA719_001890 ENOG41067S9 phage shock protein C, PspC EA719_001900 ENOG4105CSU acyl-Coa dehydrogenase EA719_001915 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EA719_001930 ENOG4105ECY inositol monophosphatase EA719_001935 ENOG4105C1J atp-dependent rna helicase EA719_001945 ENOG4105DHJ ABC, transporter EA719_001950 ENOG4105CY3 ABC transporter, permease EA719_001960 ENOG4105E3I toluene tolerance EA719_001970 ENOG4105D7N magnesium and cobalt transport protein CorA EA719_001975 ENOG4108URH decarboxylase EA719_001985 ENOG4105MJ2 Competence protein EA719_001990 ENOG4105CB5 ATP-dependent DNA helicase recG EA719_002010 ENOG4105C29 acyl-CoA thioesterase EA719_002015 ENOG4105CK2 sodium dicarboxylate symporter EA719_002030 ENOG4105KPV Transcriptional regulator EA719_002040 ENOG4105D7A ATP-binding protein EA719_002045 ENOG4105C28 cystathionine EA719_002050 ENOG41089BK Glutamine amido-transferase EA719_002160 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EA719_002165 ENOG41067V7 50S ribosomal protein L36 EA719_002175 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EA719_002200 ENOG4105C1G acyl-Coa dehydrogenase EA719_002235 ENOG4105VKU nucleicacid-binding protein EA719_002240 ENOG4105DGW oligopeptidase A EA719_002245 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EA719_002290 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EA719_002295 ENOG4108K2B transcriptional regulator EA719_002305 ENOG4107S2Z UPF0761 membrane protein EA719_002310 ENOG4105CS1 NAD(P)H quinone oxidoreductase EA719_002340 ENOG4105C9A Phoh family EA719_002350 ENOG4105E4C Lytic transglycosylase catalytic EA719_002380 ENOG4105D6S protein involved in catabolism of external DNA EA719_002385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EA719_002430 ENOG4105C1G acyl-Coa dehydrogenase EA719_002435 ENOG4108RZE Tetr family transcriptional regulator EA719_002450 ENOG4107QX3 carboxylase EA719_002455 ENOG4105C1G acyl-Coa dehydrogenase EA719_002475 ENOG4105KB2 stringent starvation protein b EA719_002480 ENOG4107MKT Stringent starvation protein a EA719_002485 ENOG4108UJD 30S ribosomal protein S9 EA719_002495 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EA719_002500 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EA719_002505 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EA719_002525 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EA719_002535 ENOG4107RZC phospholipase d EA719_002545 ENOG4105UYK outer membrane protein a EA719_002550 ENOG4108KHX Diguanylate cyclase EA719_002585 ENOG4107QN2 dihydrolipoyl dehydrogenase EA719_002595 ENOG4107QPB Beta-lactamase domain protein EA719_002600 ENOG4107U2T alpha beta EA719_002610 ENOG4105NAU thioesterase Superfamily protein EA719_002640 ENOG4105K9H YciI-like protein EA719_002650 ENOG4105DB7 PHP domain protein EA719_002655 ENOG4105FFC UPF0187 protein EA719_002665 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EA719_002670 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EA719_002675 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EA719_002680 ENOG4105VIE preprotein translocase, subunit YajC EA719_002730 ENOG4105BZU Histidine kinase EA719_002735 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EA719_002740 ENOG4105CM2 brancheD-chain amino acid aminotransferase EA719_002755 ENOG4107BJW polysaccharide deacetylase EA719_002765 ENOG4108PQP glycosyl transferase group 1 EA719_002805 ENOG4105UGU tonB-dependent Receptor EA719_002825 ENOG4108VY7 phosphate-starvation-inducible protein PsiE EA719_002830 ENOG4108K3A Glutathione S-transferase EA719_002835 ENOG4108R4R Iron-regulated virulence regulatory protein EA719_002840 ENOG4105CSU acyl-Coa dehydrogenase EA719_002845 ENOG4105CSU acyl-Coa dehydrogenase EA719_002855 ENOG4105EB3 Histidine kinase EA719_002860 ENOG4105E3W Two component transcriptional regulator (Winged helix family EA719_002865 ENOG4105CNG UPF0061 protein EA719_002885 ENOG4108WBT adenosyltransferase EA719_002900 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EA719_002935 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EA719_002955 ENOG4105D3R alkyl hydroperoxide reductase EA719_002970 ENOG4105CSH Transporter EA719_002975 ENOG4108UT2 hemolysin iii EA719_003005 ENOG4105CHU acetyl-coa acetyltransferase EA719_003010 ENOG4108R6W Transcriptional regulator, ARAC family EA719_003020 ENOG4105TW1 Carbohydrate-selective porin OprB EA719_003025 ENOG4105DZG Dehydrogenase EA719_003030 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EA719_003040 ENOG410814C multidrug resistance protein EA719_003050 ENOG4105CHU acetyl-coa acetyltransferase EA719_003060 ENOG4108WHA ompa motb domain protein EA719_003070 ENOG4105E0Y RtcB Protein EA719_003075 ENOG4108IQI permease EA719_003085 ENOG4105C2W permease EA719_003105 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EA719_003115 ENOG4108VX5 3-methyladenine DNA glycosylase EA719_003120 ENOG4105CHB tonB-dependent Receptor EA719_003135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EA719_003140 ENOG4108N2Y auxin Efflux EA719_003150 ENOG4105T95 Thiol disulfide interChange protein EA719_003155 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EA719_003165 ENOG4105K78 MarR family Transcriptional regulator EA719_003170 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EA719_003175 ENOG4105KWI UPF0339 protein EA719_003200 ENOG4108UNF response regulator EA719_003205 ENOG4105M3Z response regulator EA719_003210 ENOG4108ZGA chew protein EA719_003215 ENOG4105C8Q Methyl-accepting chemotaxis EA719_003220 ENOG4105CBS Chea signal transduction histidine kinase EA719_003235 ENOG4106HKS Entericidin EcnA/B family EA719_003245 ENOG4105WD1 Membrane EA719_003250 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EA719_003290 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EA719_003300 ENOG4105EM2 membrane EA719_003305 ENOG4105C2C drug resistance transporter, Bcr CflA EA719_003325 ENOG4105BZG amino acid carrier protein EA719_003330 ENOG4105D78 K07001 NTE family protein EA719_003335 ENOG4105C7B Threonine dehydratase EA719_003370 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EA719_003380 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EA719_003385 ENOG4105DFF Rod shape-determining protein mreb EA719_003390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EA719_003395 ENOG4105VQ7 Rod shape-determining protein MreD EA719_003400 ENOG4108Z03 MAF-like protein EA719_003405 ENOG4105C03 ribonuclease EA719_003415 ENOG4105D8T Acyltransferase EA719_003425 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein EA719_003435 ENOG4108X0B nad(p)h dehydrogenase (quinone) EA719_003460 ENOG4105CF7 AraC family transcriptional regulator EA719_003480 ENOG4105C85 amino acid EA719_003485 ENOG4105C7F AcnD-accessory protein PrpF EA719_003490 ENOG4105CTB Polyprenyl synthetase EA719_003495 ENOG4105MSB protein, conserved in bacteria EA719_003510 ENOG4105D78 K07001 NTE family protein EA719_003530 ENOG4105DIJ Phosphoethanolamine transferase EA719_003535 ENOG4105XJC Two component transcriptional regulator (Winged helix family EA719_003540 ENOG4105DHQ Histidine kinase EA719_003560 ENOG4108M0I Transcriptional regulator EA719_003580 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EA719_003600 ENOG4105K8R UPF0145 protein EA719_003605 ENOG4105K8R UPF0145 protein EA719_003610 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EA719_003615 ENOG4105BZS acriflavin resistance protein EA719_003620 ENOG4105C1P efflux transporter, rnd family, mfp subunit EA719_003625 ENOG410841Q phosphoesterase PA-phosphatase related protein EA719_003655 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) EA719_003670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EA719_003675 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EA719_003680 ENOG4105KVH Transcriptional regulator EA719_003690 ENOG4105CUB amino acid EA719_003705 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EA719_003710 ENOG41084BA UPF0250 protein EA719_003715 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EA719_003755 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EA719_003760 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EA719_003770 ENOG4105E33 succinate dehydrogenase EA719_003785 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EA719_003790 ENOG4105C7S Dehydrogenase EA719_003795 ENOG4107QN2 dihydrolipoyl dehydrogenase EA719_003805 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EA719_003815 ENOG4105CKW Inner membrane protein yedI EA719_003820 ENOG4105CGZ zinc metallopeptidase EA719_003825 ENOG4105EEQ Na H antiporter EA719_003895 ENOG4105PNM synthesis protein EA719_003910 ENOG41080TK Universal stress protein EA719_003925 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EA719_003930 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EA719_003945 ENOG4105HBR Rna-binding protein EA719_003955 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EA719_003960 ENOG4105EEI dihydropteroate synthase EA719_004010 ENOG4105CSH Transporter EA719_004015 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EA719_004020 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EA719_004035 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EA719_004055 ENOG41080IJ Diacylglycerol kinase EA719_004065 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EA719_004070 ENOG4105BZS acriflavin resistance protein EA719_004085 ENOG4105E4C Lytic transglycosylase catalytic EA719_004110 ENOG4108RRZ Transcription elongation factor GreB EA719_004125 ENOG4105CEY Amp-dependent synthetase and ligase EA719_004170 ENOG4105BZW Glycerate kinase EA719_004175 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EA719_004180 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EA719_004195 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EA719_004205 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EA719_004210 ENOG4105C85 amino acid EA719_004220 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EA719_004230 ENOG4105N14 lysine exporter protein LysE YggA EA719_004235 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EA719_004240 ENOG4105BZJ Electron transfer flavoprotein EA719_004245 ENOG4105C10 Electron transfer flavoprotein EA719_004250 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EA719_004285 ENOG4107KET secretion protein, HlyD family EA719_004315 ENOG4105D60 lipoprotein releasing system transmembrane protein EA719_004320 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EA719_004325 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EA719_004335 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EA719_004340 ENOG4107R6F Alpha Beta Hydrolase Fold protein EA719_004345 ENOG4108V3E phosphoribosylglycinamide formyltransferase EA719_004355 ENOG4105C02 permease EA719_004405 ENOG4105KCK Peptidoglycan-associated lipoprotein EA719_004410 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EA719_004420 ENOG4105M8F Biopolymer transport protein exbD tolR EA719_004425 ENOG4105E02 MotA TolQ exbB proton channel EA719_004430 ENOG4107YD3 Thioesterase EA719_004435 ENOG4105CH2 amidohydrolase EA719_004455 ENOG4108ETH Formylglycinamide ribotide synthetase EA719_004460 ENOG4105C2C drug resistance transporter, Bcr CflA EA719_004465 ENOG4105EGD dinuclear metal center protein, YbgI family EA719_004470 ENOG4108UKI Enoyl-CoA hydratase EA719_004485 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EA719_004500 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EA719_004505 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EA719_004530 ENOG4107R11 Transcriptional regulator EA719_004535 ENOG4108IJ6 ABC transporter EA719_004545 ENOG4108I5D sulfate abc transporter EA719_004555 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EA719_004560 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EA719_004565 ENOG4105HHA aminodeoxychorismate lyase EA719_004580 ENOG4108IYU L-aspartate oxidase EA719_004585 ENOG4105C0H protease EA719_004600 ENOG4105C3F Signal peptidase i EA719_004615 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EA719_004625 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) EA719_004630 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EA719_004635 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase EA719_004640 ENOG4105EMU Dehydrogenase EA719_004680 ENOG4105BZU Histidine kinase EA719_004690 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EA719_004700 ENOG4105DTR rard protein EA719_004735 ENOG4107QS8 (LipO)protein EA719_004740 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EA719_004745 ENOG4105EA8 2-Nitropropane dioxygenase EA719_004775 ENOG4107R8N Glycosyl transferase, family 2 EA719_004790 ENOG4105CVP deoxyribo-dipyrimidine photolyase EA719_004795 ENOG4108YZY peptidylprolyl cis-trans isomerase EA719_004800 ENOG4105CEP NADH dehydrogenase EA719_004805 ENOG4105DZ1 carboxypeptidase EA719_004815 ENOG4105E9K Isocitrate dehydrogenase EA719_004820 ENOG4108R99 pseudouridine synthase EA719_004845 ENOG4105CBP Major Facilitator EA719_004850 ENOG4105EGI Transcriptional regulator EA719_004855 ENOG4108ETY sodium dicarboxylate symporter EA719_004860 ENOG4105JAB phenazine biosynthesis protein, phzf family EA719_004890 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EA719_004905 ENOG4105D3G Pseudouridine synthase EA719_004910 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EA719_004925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EA719_004950 ENOG4108JPW Aminotransferase EA719_004955 ENOG4105DY8 decarboxylase EA719_004965 ENOG4105F7P transcriptional regulator AsnC family EA719_004970 ENOG4107RA9 decarboxylase EA719_004975 ENOG4105C85 amino acid EA719_004980 ENOG4105CVA phosphate EA719_004985 ENOG4105C8U phosphate abc transporter EA719_004995 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EA719_005000 ENOG4105ERU peptidase EA719_005015 ENOG4107QTF adenylosuccinate lyase EA719_005035 ENOG4108Z0R Transferase EA719_005040 ENOG4105DZ1 carboxypeptidase EA719_005060 ENOG4108K5P (LipO)protein EA719_005065 ENOG4105EJC lysr family transcriptional regulator EA719_005070 ENOG4105DAN ATP-dependent protease EA719_005085 ENOG4105DHU Bile acid EA719_005105 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EA719_005115 ENOG4105D22 carbon starvation protein EA719_005120 ENOG4105VCD cytoplasmic protein EA719_005155 ENOG4108K8K Transcriptional regulator EA719_005170 ENOG4105C26 Dehydrogenase EA719_005175 ENOG4105C85 amino acid EA719_005180 ENOG4105ETT transcriptional Regulator, LysR family EA719_005185 ENOG4105C94 Transporter EA719_005190 ENOG4105C94 Transporter EA719_005200 ENOG4105C26 Dehydrogenase EA719_005205 ENOG4107QZF nitrite reductase NADPH large subunit EA719_005210 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EA719_005240 ENOG41060M8 Pfam:PhdYeFM EA719_005245 ENOG4107QNK )-transporter EA719_005250 ENOG4107WEA mandelate racemase muconate lactonizing EA719_005260 ENOG4105J7D transcriptional regulator EA719_005280 ENOG4105C2I pirin domain protein EA719_005290 ENOG4105WWK YheO domain protein EA719_005305 ENOG4105CEY Amp-dependent synthetase and ligase EA719_005320 ENOG4108IPW abc transporter atp-binding protein EA719_005340 ENOG4105C0W non-ribosomal peptide synthetase EA719_005345 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EA719_005350 ENOG4105WQI isochorismatase EA719_005365 ENOG4105BZ1 (ABC) transporter EA719_005385 ENOG4105E4F Isochorismate synthase EA719_005400 ENOG4105NX3 Membrane EA719_005425 ENOG4105EUJ GTP cyclohydrolase i EA719_005435 ENOG4105C7W Xanthine dehydrogenase EA719_005465 ENOG4105CD8 aminopeptidase N EA719_005470 ENOG4105DDQ anthranilate synthase EA719_005480 ENOG4105DUX Transporter EA719_005485 ENOG4105C5F glutamine synthetase EA719_005495 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) EA719_005530 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EA719_005535 ENOG4107QNR UPF0135 protein EA719_005540 ENOG4105C0H protease EA719_005550 ENOG4105C6K Malic enzyme EA719_005555 ENOG4105BZU Histidine kinase EA719_005560 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EA719_005565 ENOG4105SYT Methylenetetrahydrofolate reductase EA719_005570 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EA719_005585 ENOG4107QPN acyl-Coa dehydrogenase EA719_005590 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EA719_005595 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EA719_005605 ENOG4107RNU major facilitator superfamily MFS_1 EA719_005615 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EA719_005620 ENOG4105CE9 30S ribosomal protein S2 EA719_005660 ENOG4105CVE Lytic murein transglycosylase EA719_005665 ENOG4105CNI cell division protein FtsW EA719_005680 ENOG4105E3A (ABC) transporter EA719_005685 ENOG4105DA5 (ABC) transporter EA719_005720 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EA719_005730 ENOG4105ENT Efflux transporter rnd family, mfp subunit EA719_005740 ENOG4105E89 ABC transporter EA719_005745 ENOG4105DSP amino acid AbC transporter EA719_005750 ENOG4106YG3 ABC transporter EA719_005755 ENOG4108JEH abc transporter atp-binding protein EA719_005765 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EA719_005770 ENOG4105CFP Peptidase U32 EA719_005775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EA719_005780 ENOG4105JAB phenazine biosynthesis protein, phzf family EA719_005785 ENOG4105DP0 ferredoxin-NADP reductase EA719_005790 ENOG4108R96 Methyltransferase, YaeB family EA719_005800 ENOG4107QHF type ii secretion system protein e EA719_005810 ENOG4105XJC Two component transcriptional regulator (Winged helix family EA719_005815 ENOG4105DHQ Histidine kinase EA719_005825 ENOG4105M6F mutator MutT protein EA719_005835 ENOG4105BZ4 penicillin-binding protein EA719_005840 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EA719_005845 ENOG4105VUT cytoplasmic protein EA719_005850 ENOG4107QYG anthranilate phosphoribosyltransferase EA719_005860 ENOG4105CK2 sodium dicarboxylate symporter EA719_005865 ENOG4105C1G acyl-Coa dehydrogenase EA719_005870 ENOG4105NIV Esterase EA719_005875 ENOG4105CQC Prephenate dehydratase EA719_005880 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EA719_005890 ENOG4105CIN aminoacyl-histidine dipeptidase EA719_005895 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EA719_005925 ENOG4105M08 Membrane EA719_005930 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EA719_005940 ENOG4105VEQ Cold shock protein EA719_005945 ENOG4105C1J atp-dependent rna helicase EA719_005955 ENOG41069NU Nitroreductase EA719_005990 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EA719_006005 ENOG4105C5I Dehydrogenase EA719_006010 ENOG4105ERG peptidase m48, ste24p EA719_006015 ENOG4105KTH gatB Yqey EA719_006020 ENOG4105VCC 30S ribosomal protein S21 EA719_006045 ENOG4105D9P serine threonine protein kinase EA719_006070 ENOG4105EVZ LysR family transcriptional regulator EA719_006075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EA719_006080 ENOG4105C26 Dehydrogenase EA719_006115 ENOG4105H4F exported protein EA719_006145 ENOG4105D6U Sodium Glutamate Symporter EA719_006155 ENOG4105JXH GntR family transcriptional regulator EA719_006270 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EA719_006345 ENOG4105CK2 sodium dicarboxylate symporter EA719_006355 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EA719_006360 ENOG4108UMI ABC transporter, permease EA719_006365 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EA719_006375 ENOG4105C12 Phosphoribosylglycinamide synthetase EA719_006380 ENOG4105DC1 bifunctional purine biosynthesis protein purh EA719_006385 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EA719_006435 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EA719_006440 ENOG4105CDU Replicative dna helicase EA719_006465 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EA719_006470 ENOG4105CCU oxidase (Subunit III) EA719_006475 ENOG4105BZ9 Cytochrome C oxidase, subunit I EA719_006480 ENOG4105E2S oxidase) subunit II EA719_006505 ENOG4107BJW polysaccharide deacetylase EA719_006510 ENOG4105CND Glycosyl transferase, family 2 EA719_006515 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD EA719_006525 ENOG4105DEN Luciferase family EA719_006545 ENOG4105CC0 LysR family Transcriptional regulator EA719_006560 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EA719_006565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EA719_006570 ENOG4105GVF (ABC) transporter EA719_006585 ENOG4105C1G acyl-Coa dehydrogenase EA719_006595 ENOG4108MEJ flavin reductase domain protein EA719_006600 ENOG4105D06 uba thif-type nad fad binding protein EA719_006620 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EA719_006625 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EA719_006635 ENOG4105C08 Histidine kinase EA719_006640 ENOG4105EEX Two component transcriptional regulator (Winged helix family EA719_006645 ENOG4105CFQ glutamine synthetase EA719_006660 ENOG4107S74 Lysophospholipid transporter LplT EA719_006665 ENOG4105CFU surface antigen EA719_006685 ENOG4107QIJ Aconitate hydratase 2 EA719_006695 ENOG4105EYW Ion transport protein EA719_006700 ENOG4105F27 Major Facilitator EA719_006715 ENOG4105DZ2 Transcriptional regulator EA719_006750 ENOG4105K8N protein family UPF0079, ATPase EA719_006755 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EA719_006765 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EA719_006770 ENOG4108TZV Membrane EA719_006775 ENOG4108RCM Nitroreductase EA719_006785 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) EA719_006800 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EA719_006805 ENOG4107FQ9 ethanolamine ammonia-lyase EA719_006810 ENOG4105CPD ethanolamine ammonia-lyase EA719_006815 ENOG4107R55 ethanolamine transporter EA719_006825 ENOG4107RR1 TRANSCRIPTIONal EA719_006835 ENOG4105C0A alcohol dehydrogenase EA719_006840 ENOG4107QUV Domain protein EA719_006850 ENOG4105F4I Transcriptional regulator EA719_006870 ENOG4105CD8 aminopeptidase N EA719_006880 ENOG4105EMU Dehydrogenase EA719_006890 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) EA719_006895 ENOG4105EW9 transcriptional regulator AsnC family EA719_006910 ENOG4105R8C Transcriptional regulator EA719_006920 ENOG4105CUY Mechanosensitive ion channel EA719_006955 ENOG4105CNM Receptor EA719_006975 ENOG4105C5H ABC transporter EA719_006980 ENOG41081QV Universal stress protein EA719_006995 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EA719_007005 ENOG4105DKK Benzoate EA719_007010 ENOG4105EW9 transcriptional regulator AsnC family EA719_007015 ENOG4108NIW Leucine export protein LeuE EA719_007020 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EA719_007025 ENOG4105C5Q Transcriptional regulator EA719_007035 ENOG4105CHU acetyl-coa acetyltransferase EA719_007040 ENOG4105CHR reductase EA719_007065 ENOG4107QMP dna polymerase iii subunits gamma and tau EA719_007070 ENOG4105HSS phospholipase C EA719_007080 ENOG4105C0A alcohol dehydrogenase EA719_007110 ENOG4105CBC glutamate synthase EA719_007265 ENOG4105UPP uncharacterized protein ydcA EA719_007295 ENOG4105DR5 peptidase EA719_007390 ENOG4105D8G Major Facilitator superfamily EA719_007440 ENOG4105CHH sulfate transporter EA719_007455 ENOG4105F6A helicase EA719_007465 ENOG4108HWY Beta-lactamase EA719_007480 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EA719_007485 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EA719_007510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EA719_007520 ENOG4107QZF nitrite reductase NADPH large subunit EA719_007525 ENOG4108IFG nitrite reductase, (NAD(P)H) EA719_007545 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EA719_007560 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EA719_007565 ENOG4105CVM Molybdenum cofactor synthesis domain protein EA719_007575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EA719_007580 ENOG4105T38 integral membrane protein EA719_007600 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) EA719_007605 ENOG4105CMR udp-glucose 4-epimerase EA719_007680 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EA719_007685 ENOG4105CUX Signal transduction histidine kinase EA719_007710 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EA719_007715 ENOG4105KNE Phosphatidate cytidylyltransferase EA719_007725 ENOG4105DZP Membrane-associated zinc metalloprotease EA719_007750 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EA719_007765 ENOG4105Y3E Modulates RecA activity (By similarity) EA719_007775 ENOG4105VEJ Heat shock protein EA719_007780 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 EA719_007805 ENOG4105F7P transcriptional regulator AsnC family EA719_007815 ENOG4105C85 amino acid EA719_007830 ENOG4105CHH sulfate transporter EA719_007835 ENOG4108RAV Conserved protein EA719_007840 ENOG4105D8V Glucose sorbosone dehydrogenase EA719_007850 ENOG4105BZU Histidine kinase EA719_007870 ENOG4105DM4 PTS System EA719_007875 ENOG4105DE4 1-phosphofructokinase EA719_007880 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EA719_007905 ENOG4105CWM branched-chain amino acid transport system II carrier protein EA719_007910 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EA719_007915 ENOG4105CC0 LysR family Transcriptional regulator EA719_007925 ENOG4105M2J Glutaredoxin EA719_007930 ENOG4105C8Y Acetylornithine aminotransferase EA719_007935 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EA719_007960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EA719_007970 ENOG41068P6 UPF0319 protein EA719_007990 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EA719_007995 ENOG4105C4M (Ubiquinol oxidase) subunit I EA719_008005 ENOG4105PV3 Inner membrane protein yqiJ EA719_008020 ENOG4105E0K tonB-dependent siderophore receptor EA719_008030 ENOG4105HDD phospholipase EA719_008035 ENOG4105CZN Potassium uptake protein EA719_008045 ENOG4105C7B Threonine dehydratase EA719_008075 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EA719_008080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EA719_008090 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EA719_008105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EA719_008150 ENOG4107VMU Membrane EA719_008155 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EA719_008165 ENOG4107QP7 CoA-transferase subunit A EA719_008170 ENOG4107QNJ CoA-transferase subunit B EA719_008175 ENOG4105CHU acetyl-coa acetyltransferase EA719_008180 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase EA719_008185 ENOG4105F2Z 3-oxoadipate enol-lactonase EA719_008190 ENOG4105D2S major facilitator superfamily EA719_008195 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EA719_008200 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta EA719_008205 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha EA719_008210 ENOG4105FF2 Type I DHQase EA719_008215 ENOG4106JPM 3-dehydroshikimate dehydratase EA719_008220 ENOG4105TW1 Carbohydrate-selective porin OprB EA719_008225 ENOG4105DZG Dehydrogenase EA719_008235 ENOG4105MD1 YeeE YedE family protein EA719_008250 ENOG4107HP6 Transcriptional regulator EA719_008255 ENOG4108PTX LysR family Transcriptional regulator EA719_008260 ENOG4105C1G acyl-Coa dehydrogenase EA719_008285 ENOG4105DNH Major Facilitator EA719_008295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EA719_008315 ENOG4105FUY alpha subunit EA719_008325 ENOG4105CHR reductase EA719_008345 ENOG4105F11 amine oxidase EA719_008355 ENOG4105C26 Dehydrogenase EA719_008365 ENOG4105F2Z 3-oxoadipate enol-lactonase EA719_008370 ENOG4105CHU acetyl-coa acetyltransferase EA719_008375 ENOG4107QNJ CoA-transferase subunit B EA719_008380 ENOG4107QP7 CoA-transferase subunit A EA719_008390 ENOG4105NN7 muconolactone delta-isomerase EA719_008395 ENOG4105DTQ mandelate racemase muconate lactonizing EA719_008400 ENOG4108KB2 LysR family Transcriptional regulator EA719_008410 ENOG4107EJG GntR family transcriptional regulator EA719_008430 ENOG4105CZJ Aldehyde dehydrogenase EA719_008450 ENOG4105C1G acyl-Coa dehydrogenase EA719_008460 ENOG4108JU7 Transcriptional regulator EA719_008470 ENOG41062QD Membrane EA719_008485 ENOG4107RGH Aldehyde dehydrogenase EA719_008500 ENOG4105CH6 catalase EA719_008525 ENOG4105K56 Transcriptional regulator EA719_008530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EA719_008540 ENOG4105NAE bifunctional deaminase-reductase domain protein EA719_008570 ENOG4107Z3H Transcriptional regulator, TetR family EA719_008580 ENOG4105CHJ isochorismatase hydrolase EA719_008585 ENOG4105EJC lysr family transcriptional regulator EA719_008590 ENOG4105D8V Glucose sorbosone dehydrogenase EA719_008595 ENOG4105CKD glutathione-regulated potassium-efflux system protein EA719_008605 ENOG4105CH2 amidohydrolase EA719_008620 ENOG4105D5K Hemolysin activator protein EA719_008625 ENOG4105CKT filamentous hemagglutinin EA719_008655 ENOG4105FDP GntR family transcriptional regulator EA719_008680 ENOG4106KR7 LysR family Transcriptional regulator EA719_008705 ENOG4108JQ1 Dehydrogenase EA719_008710 ENOG4105JSC dimethylmenaquinone methyltransferase EA719_008730 ENOG4105CW7 secretion protein, HlyD family EA719_008745 ENOG4105CZJ Aldehyde dehydrogenase EA719_008750 ENOG4105C01 Dihydroxy-acid dehydratase EA719_008760 ENOG4105DDW LysR family Transcriptional regulator EA719_008765 ENOG4105EXW epimerase dehydratase EA719_008775 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EA719_008780 ENOG4105CF7 AraC family transcriptional regulator EA719_008795 ENOG4105DQ4 alcohol dehydrogenase EA719_008805 ENOG4105EHG Permease protein EA719_008810 ENOG4105E0A ABC, transporter EA719_008830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EA719_008910 ENOG4108UAJ Transcriptional regulator EA719_008950 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EA719_009005 ENOG4108BAS reductase EA719_009020 ENOG4108R6W Transcriptional regulator, ARAC family EA719_009025 ENOG4108821 RND type efflux pump EA719_009030 ENOG4105E0F Histidine kinase EA719_009035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EA719_009040 ENOG4105C1P efflux transporter, rnd family, mfp subunit EA719_009045 ENOG4105BZS acriflavin resistance protein EA719_009050 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EA719_009060 ENOG4105CT3 Monooxygenase EA719_009080 ENOG4105CJP fad dependent oxidoreductase EA719_009100 ENOG4105X0I Fimbrial EA719_009155 ENOG4107RZC phospholipase d EA719_009175 ENOG4108IGT Dipeptidase EA719_009210 ENOG4107T31 5'-nucleotidase EA719_009220 ENOG4105WQI isochorismatase EA719_009225 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EA719_009230 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EA719_009235 ENOG4105E0C molybdate abc transporter EA719_009240 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EA719_009245 ENOG4105F4R Transcriptional regulator mode EA719_009250 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit EA719_009255 ENOG4108YS2 small subunit EA719_009260 ENOG4105F57 Anthranilate dioxygenase reductase EA719_009285 ENOG4105CHR reductase EA719_009295 ENOG4105D2S major facilitator superfamily EA719_009300 ENOG4105CF7 AraC family transcriptional regulator EA719_009310 ENOG4105DTD Dehydrogenase EA719_009315 ENOG4105CY2 Citrate transporter EA719_009325 ENOG4108M0I Transcriptional regulator EA719_009335 ENOG4107QNJ CoA-transferase subunit B EA719_009340 ENOG4105CRW Short chain fatty acid transporter EA719_009345 ENOG4105CHU acetyl-coa acetyltransferase EA719_009355 ENOG4107YNJ LysR family Transcriptional regulator EA719_009370 ENOG4108IJ0 Aspartate ammonia-lyase EA719_009380 ENOG4105CSH Transporter EA719_009400 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EA719_009405 ENOG4106FTQ Taurine ABC transporter, periplasmic EA719_009420 ENOG4105FDP GntR family transcriptional regulator EA719_009430 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EA719_009435 ENOG4105KVH Transcriptional regulator EA719_009440 ENOG4105UEI Transcriptional Regulator AraC Family EA719_009455 ENOG4108VCT Sulfite exporter TauE/SafE EA719_009465 ENOG4107QPB Beta-lactamase domain protein EA719_009475 ENOG4105FFC UPF0187 protein EA719_009485 ENOG4105CHR reductase EA719_009500 ENOG4105CPP Dehydrogenase, E1 component EA719_009505 ENOG4107R0V Pyruvate dehydrogenase EA719_009510 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EA719_009525 ENOG4105BZU Histidine kinase EA719_009535 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EA719_009540 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EA719_009585 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EA719_009600 ENOG4105C28 cystathionine EA719_009610 ENOG4105F2W methyltransferase EA719_009640 ENOG4105K59 histidine triad (HIT) protein EA719_009665 ENOG4107QWP ABC-2 type transporter EA719_009670 ENOG4107QWP ABC-2 type transporter EA719_009675 ENOG4105CJ1 ABC, transporter EA719_009690 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EA719_009695 ENOG4105CNM Receptor EA719_009715 ENOG4107TSN permease EA719_009720 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EA719_009740 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EA719_009745 ENOG4108YZT Adenosylcobinamide kinase EA719_009800 ENOG4105DJU Siderophore biosynthesis protein EA719_009805 ENOG4105DUU IucA IucC family protein EA719_009825 ENOG4108Z66 YbaK ebsC protein EA719_009840 ENOG4105C1G acyl-Coa dehydrogenase EA719_009845 ENOG4105C1G acyl-Coa dehydrogenase EA719_009850 ENOG4105EEF Alkane 1-monooxygenase EA719_009855 ENOG4105E7U AraC family transcriptional regulator EA719_009860 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EA719_009865 ENOG4105K70 DNA-binding protein EA719_009880 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EA719_009890 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EA719_009895 ENOG4108Z4V iron-sulfur cluster assembly EA719_009910 ENOG4108ZIT Ferredoxin, 2FE-2S EA719_009915 ENOG4105F8J Adenylate Guanylate cyclase EA719_009925 ENOG4108JA2 transcriptioN-repair coupling factor EA719_009945 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) EA719_009950 ENOG4105K4T epimerase EA719_009965 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EA719_009985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EA719_009995 ENOG4105DGW oligopeptidase A EA719_010035 ENOG4105SG9 biopolymer transport protein, ExbD EA719_010045 ENOG4107QP3 malate synthase g EA719_010050 ENOG4105D6Z AFG1 family ATPase EA719_010060 ENOG4107RN6 Monooxygenase EA719_010080 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EA719_010085 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EA719_010100 ENOG4108Z6B deaminase EA719_010120 ENOG4108RTD type II secretion system protein K EA719_010145 ENOG4105F8V Hydrolase, tatD family EA719_010155 ENOG4107QRG dna polymerase iii EA719_010165 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EA719_010170 ENOG4105BZ1 (ABC) transporter EA719_010185 ENOG4105FA0 parb-like partition protein EA719_010190 ENOG4107QJE Chromosome Partitioning Protein EA719_010200 ENOG4108S0S Nucleotidyl transferase EA719_010205 ENOG4105EHM Aminoglycoside phosphotransferase EA719_010210 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EA719_010215 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EA719_010220 ENOG4105D2N Aldolase EA719_010240 ENOG4108UHJ MAF-like protein EA719_010245 ENOG4105EZE Cupin 4 family protein EA719_010255 ENOG41080HT Transcriptional regulator, arsr family EA719_010265 ENOG4105XPP Protein of unknown function (DUF1275) EA719_010270 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme EA719_010275 ENOG4105BZ1 (ABC) transporter EA719_010285 ENOG4108ZX5 transcriptional regulator EA719_010295 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EA719_010300 ENOG4105CK7 Sodium proline symporter EA719_010305 ENOG4105EW9 transcriptional regulator AsnC family EA719_010310 ENOG4105C26 Dehydrogenase EA719_010315 ENOG4105YGK Pfam:UPF0157 EA719_010330 ENOG4108T58 Mg2 transport protein CorA EA719_010340 ENOG4107RYR Transcriptional regulator, Crp Fnr family EA719_010345 ENOG4108UKZ OsmC family EA719_010360 ENOG4108YYC ycei family EA719_010370 ENOG4105CV1 Transketolase (EC 2.2.1.1) EA719_010395 ENOG4108HWY Beta-lactamase EA719_010415 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EA719_010420 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EA719_010440 ENOG4105X0I Fimbrial EA719_010445 ENOG4105GQR Chaperone EA719_010475 ENOG4108IPJ Membrane EA719_010485 ENOG4105ETS cytosine purines uracil thiamine allantoin EA719_010495 ENOG4105CC0 LysR family Transcriptional regulator EA719_010515 ENOG41067SE Tetr family transcriptional regulator EA719_010525 ENOG4105CDA abc transporter atp-binding protein EA719_010530 ENOG4105DRP amino acid AbC transporter EA719_010535 ENOG4105EAD ABC transporter EA719_010550 ENOG4107T8P acyl-Coa dehydrogenase EA719_010565 ENOG4105D01 (LipO)protein EA719_010570 ENOG4105D01 (LipO)protein EA719_010575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EA719_010580 ENOG4108UMI ABC transporter, permease EA719_010585 ENOG4105C3G gtp-binding protein EA719_010610 ENOG4108UMN azlc family EA719_010615 ENOG4105ZED uncharacterized protein ygaH EA719_010645 ENOG4105E7U AraC family transcriptional regulator EA719_010650 ENOG4108V06 Glutathione peroxidase EA719_010660 ENOG4105CHM Aminotransferase EA719_010675 ENOG4105C0B DNA polymerase III (alpha subunit) EA719_010700 ENOG4108JU3 Alkyl hydroperoxide reductase EA719_010715 ENOG4108KB2 LysR family Transcriptional regulator EA719_010720 ENOG4105D6J arsenicaL-resistance protein EA719_010725 ENOG41082YX Transcriptional regulator, arsr family EA719_010740 ENOG4105CPN adenine deaminase EA719_010750 ENOG4105CBN LysR family transcriptional regulator EA719_010760 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EA719_010770 ENOG4105E2B Taurine dioxygenase EA719_010775 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EA719_010780 ENOG4108IY8 ABC, transporter EA719_010785 ENOG4106FTQ Taurine ABC transporter, periplasmic EA719_010795 ENOG4105C54 Major Facilitator superfamily EA719_010820 ENOG4105C4M (Ubiquinol oxidase) subunit I EA719_010825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EA719_010835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EA719_010840 ENOG4108K70 Transcriptional regulator EA719_010855 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EA719_010860 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase EA719_010875 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) EA719_010880 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase EA719_010890 ENOG4105DXI Major Facilitator superfamily EA719_010910 ENOG41067MG lrgb family EA719_010915 ENOG4105VAW lrga family EA719_010920 ENOG4105CMU LysR family (Transcriptional regulator EA719_010925 ENOG4108SHQ Glutathione S-transferase EA719_010930 ENOG4105CYM Glutathione S-transferase EA719_010935 ENOG4105CBN LysR family transcriptional regulator EA719_010940 ENOG4105CHR reductase EA719_010950 ENOG4105D7W serine acetyltransferase EA719_010955 ENOG4105ESN nucleotide-binding protein EA719_010960 ENOG4105C9B Cysteine desulfurase EA719_010975 ENOG4105EXG Transcriptional regulator EA719_010985 ENOG4105CT1 (ABC) transporter EA719_010990 ENOG4107RP9 extracellular solute-binding protein, family 3 EA719_010995 ENOG4105CDA abc transporter atp-binding protein EA719_011000 ENOG4108HW4 amino acid AbC transporter EA719_011005 ENOG4105EAD ABC transporter EA719_011020 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EA719_011025 ENOG4105BZU Histidine kinase EA719_011035 ENOG4105EW9 transcriptional regulator AsnC family EA719_011045 ENOG4105KT5 UmuD protein EA719_011065 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EA719_011110 ENOG4105HEI LysR family (Transcriptional regulator EA719_011130 ENOG4105CEY Amp-dependent synthetase and ligase EA719_011135 ENOG4105R8C Transcriptional regulator EA719_011140 ENOG4105C1G acyl-Coa dehydrogenase EA719_011145 ENOG4107QX3 carboxylase EA719_011150 ENOG4105E39 Enoyl-CoA hydratase EA719_011165 ENOG4105CC0 LysR family Transcriptional regulator EA719_011180 ENOG4105CSU acyl-Coa dehydrogenase EA719_011190 ENOG4105EQ0 Major Facilitator superfamily EA719_011200 ENOG4107QNJ CoA-transferase subunit B EA719_011205 ENOG4107QP7 CoA-transferase subunit A EA719_011210 ENOG4107RGD Major Facilitator superfamily EA719_011215 ENOG4105C1G acyl-Coa dehydrogenase EA719_011220 ENOG4105E39 Enoyl-CoA hydratase EA719_011225 ENOG4105CHR reductase EA719_011230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EA719_011235 ENOG4105CHU acetyl-coa acetyltransferase EA719_011245 ENOG4105EQ0 Major Facilitator superfamily EA719_011250 ENOG4105EA8 2-Nitropropane dioxygenase EA719_011255 ENOG4108UKI Enoyl-CoA hydratase EA719_011270 ENOG4105C1G acyl-Coa dehydrogenase EA719_011275 ENOG4107RGD Major Facilitator superfamily EA719_011280 ENOG4108KAZ Involved in phosphonate degradation (By similarity) EA719_011285 ENOG4107STF Involved in phosphonate degradation (By similarity) EA719_011295 ENOG4107RCV ABC transporter, permease EA719_011300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EA719_011305 ENOG4105C4Y ABC transporter EA719_011315 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase EA719_011320 ENOG4107HP6 Transcriptional regulator EA719_011330 ENOG4105HEI LysR family (Transcriptional regulator EA719_011335 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EA719_011340 ENOG4105C26 Dehydrogenase EA719_011350 ENOG4105ETS cytosine purines uracil thiamine allantoin EA719_011360 ENOG4105C26 Dehydrogenase EA719_011365 ENOG4108M8W Monooxygenase EA719_011370 ENOG4105MXW flavin reductase domain protein, FMN-binding EA719_011375 ENOG4108MXF Alpha Beta Hydrolase EA719_011395 ENOG4105CPW cytochrome b561 EA719_011400 ENOG4107VGR Catalase EA719_011440 ENOG4107YAU phenylacetic acid degradation protein EA719_011450 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein EA719_011455 ENOG4105DZS Phenylacetate-CoA ligase EA719_011460 ENOG4105CHU acetyl-coa acetyltransferase EA719_011465 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EA719_011470 ENOG4108UKI Enoyl-CoA hydratase EA719_011475 ENOG4105E39 Enoyl-CoA hydratase EA719_011480 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EA719_011485 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit EA719_011490 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit EA719_011495 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit EA719_011500 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit EA719_011505 ENOG4105DXM phenylacetic acid degradation protein EA719_011510 ENOG4105EJQ L-serine dehydratase EA719_011515 ENOG4107QTZ amino acid EA719_011520 ENOG4105CZJ Aldehyde dehydrogenase EA719_011545 ENOG4105MWK D-amino acid dehydrogenase, small subunit EA719_011565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EA719_011580 ENOG4108Z4X TRANSCRIPTIONal EA719_011595 ENOG4105WPN DNA integration recombination invertion protein EA719_011610 ENOG4105DJ2 Major Facilitator Superfamily EA719_011615 ENOG4107Y2X deaminase EA719_011625 ENOG4105EMY transcriptional regulator EA719_011655 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EA719_011665 ENOG4105UYK outer membrane protein a EA719_011695 ENOG4108UKZ OsmC family EA719_011700 ENOG4107RYR Transcriptional regulator, Crp Fnr family EA719_011765 ENOG4108HW3 (ABC) transporter EA719_011775 ENOG4105MRR Transcriptional regulator (By similarity) EA719_011795 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF EA719_011800 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EA719_011815 ENOG4105E2A Dehydrogenase EA719_011825 ENOG4105R8C Transcriptional regulator EA719_011850 ENOG4107R4J Chloride channel EA719_011855 ENOG4108JIK carboxylase EA719_011875 ENOG4105C5A transporter EA719_011880 ENOG4108WAV Transcriptional regulator EA719_011895 ENOG4105CNA YD repeat protein EA719_011935 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) EA719_011955 ENOG4105D2S major facilitator superfamily EA719_011970 ENOG4105D1S lipid A biosynthesis EA719_011975 ENOG4105BZU Histidine kinase EA719_011980 ENOG4107AQZ Membrane EA719_012000 ENOG4108Z4U Ferredoxin EA719_012040 ENOG4105DFG type I secretion outer membrane protein EA719_012045 ENOG4108IUZ ABC transporter EA719_012050 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EA719_012060 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EA719_012065 ENOG4105C2X Arabinose 5-phosphate isomerase EA719_012100 ENOG4107YPT transcriptional regulator EA719_012135 ENOG4105II7 pyrroline-5-carboxylate reductase EA719_012145 ENOG4105VEQ Cold shock protein EA719_012150 ENOG410829K Lysine exporter protein (Lyse ygga) EA719_012185 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EA719_012240 ENOG4108KB2 LysR family Transcriptional regulator EA719_012245 ENOG4105FUY alpha subunit EA719_012250 ENOG4108UKV benzoate 1,2-dioxygenase EA719_012255 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein EA719_012260 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase EA719_012265 ENOG4105DKK Benzoate EA719_012270 ENOG4105D2S major facilitator superfamily EA719_012285 ENOG4105CQ7 ATP-dependent helicase EA719_012290 ENOG4105D3R alkyl hydroperoxide reductase EA719_012300 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EA719_012310 ENOG4108JU3 Alkyl hydroperoxide reductase EA719_012320 ENOG4108K3A Glutathione S-transferase EA719_012330 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EA719_012335 ENOG4108TGY Glutathione S-transferase EA719_012345 ENOG4108ZG0 Ompa motb domain protein EA719_012350 ENOG4105CD3 dihydroorotase EA719_012380 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EA719_012400 ENOG4108UKZ OsmC family EA719_012405 ENOG4107RYR Transcriptional regulator, Crp Fnr family EA719_012415 ENOG4105CPC Aldo Keto reductase EA719_012430 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EA719_012440 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EA719_012450 ENOG4105CFH Aspartokinase EA719_012460 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EA719_012470 ENOG4105CPW cytochrome b561 EA719_012475 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EA719_012480 ENOG4105C7N Xanthine uracil vitamin C permease EA719_012490 ENOG4105F95 Monooxygenase EA719_012540 ENOG4105C85 amino acid EA719_012560 ENOG4105C26 Dehydrogenase EA719_012580 ENOG4105CUB amino acid EA719_012590 ENOG4105C85 amino acid EA719_012635 ENOG4105CNA YD repeat protein EA719_012655 ENOG4105D01 (LipO)protein EA719_012660 ENOG4108M3P Membrane EA719_012675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EA719_012695 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EA719_012715 ENOG4108JQ5 ABC transporter EA719_012720 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EA719_012725 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EA719_012735 ENOG4105E9H Lytic Murein transglycosylase EA719_012735 ENOG4105E9H Lytic Murein transglycosylase EA719_012740 ENOG4107RZZ dna polymerase iii epsilon subunit EA719_012750 ENOG4105E09 nadh pyrophosphatase EA719_012760 ENOG4105W4M Transport-associated protein EA719_012770 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EA719_012780 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EA719_012785 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EA719_012805 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EA719_012810 ENOG4105D0A hydroxylase EA719_012815 ENOG4107RAQ aminopeptidase EA719_012850 ENOG4105DIJ Phosphoethanolamine transferase EA719_012895 ENOG4105DR5 peptidase EA719_013220 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EA719_013245 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EA719_013255 ENOG4105D82 Glutamate dehydrogenase EA719_013260 ENOG4108R3D Electron transport complex EA719_013265 ENOG4105CSM endonuclease III EA719_013290 ENOG4105CJN penicillin-binding protein EA719_013295 ENOG4106H78 methyltransferase EA719_013310 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EA719_013320 ENOG4105CQM Urea amidohydrolase subunit alpha EA719_013350 ENOG4107RET Isocitrate lyase EA719_013360 ENOG4105C37 (CBS) domain EA719_013385 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EA719_013400 ENOG4108MRJ EA719_013420 ENOG4105VCQ rubredoxin EA719_013425 ENOG4107QZF nitrite reductase NADPH large subunit EA719_013435 ENOG4105C5Q Transcriptional regulator EA719_013460 ENOG4108I0Y (ABC) transporter EA719_013465 ENOG4108UJV acyl-CoA thioesterase i EA719_013485 ENOG4107RNH Outer membrane receptor FepA EA719_013500 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) EA719_013505 ENOG4105E6M Sulphatase-modifying factor protein EA719_013525 ENOG4105CJ3 phosphate transporter EA719_013530 ENOG4105C3R Methionine synthase EA719_013545 ENOG4105CSP Major Facilitator Superfamily EA719_013555 ENOG4108PZW LysR family Transcriptional regulator EA719_013570 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EA719_013575 ENOG4105EU0 Major facilitator Superfamily EA719_013580 ENOG4108R6W Transcriptional regulator, ARAC family EA719_013585 ENOG4105CSV Glutaminase EA719_013590 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EA719_013595 ENOG4105CSH Transporter EA719_013605 ENOG4105C7K acetolactate synthase EA719_013620 ENOG4105CHR reductase EA719_013625 ENOG4108MXF Alpha Beta Hydrolase EA719_013635 ENOG4105DJB Major Facilitator Superfamily EA719_013640 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase EA719_013650 ENOG4105CHR reductase EA719_013670 ENOG41069M3 Transcriptional regulator EA719_013685 ENOG4106YT9 Enoyl-CoA hydratase EA719_013695 ENOG4105CND Glycosyl transferase, family 2 EA719_013700 ENOG4107BJW polysaccharide deacetylase EA719_013710 ENOG4108VWS Yaeq family EA719_013720 ENOG4105CKI cobalamin synthesis protein EA719_013740 ENOG4105C94 Transporter EA719_013745 ENOG4105C94 Transporter EA719_013750 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EA719_013775 ENOG4107QK5 Homocysteine s-methyltransferase EA719_013780 ENOG4105D5Q Arginine ornithine antiporter EA719_013805 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EA719_013810 ENOG4105C54 Major Facilitator superfamily EA719_013930 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EA719_013970 ENOG4105K4U addiction module toxin, RelE StbE family EA719_014115 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EA719_014120 ENOG4105C0R drug resistance transporter emrb qaca subfamily EA719_014125 ENOG4105CW7 secretion protein, HlyD family EA719_014130 ENOG4108VUY thioesterase Superfamily protein EA719_014135 ENOG4105D52 delta-aminolevulinic acid dehydratase EA719_014140 ENOG4105MWK D-amino acid dehydrogenase, small subunit EA719_014145 ENOG4105ECP epimerase EA719_014165 ENOG4107RH8 nuclease SbcCD subunit D EA719_014170 ENOG4105EYH Exonuclease EA719_014175 ENOG4105DFA alanine racemase domain protein EA719_014180 ENOG4105CZX twitching motility protein EA719_014185 ENOG4105CZX twitching motility protein EA719_014190 ENOG41090R7 Ferric uptake EA719_014220 ENOG4105E7A Glutamine amidotransferase EA719_014235 ENOG4107QKV phosphomannomutase EA719_014245 ENOG4105C4R Atp-dependent dna helicase EA719_014250 ENOG4108ZG0 Ompa motb domain protein EA719_014255 ENOG4106HNH Acyl-transferase EA719_014270 ENOG4107QMS site-determining protein EA719_014295 ENOG4105CNU cell division protein FtsK EA719_014300 ENOG4105C3M thioredoxin reductase EA719_014305 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EA719_014315 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EA719_014360 ENOG4108YXA Membrane EA719_014365 ENOG4105EUB pirin domain protein EA719_014375 ENOG4105C4K Nad synthetase EA719_014390 ENOG4105E3J oxidoreductase EA719_014395 ENOG4105C26 Dehydrogenase EA719_014400 ENOG4105DVW rieske (2Fe-2S) EA719_014410 ENOG4105C94 Transporter EA719_014415 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EA719_014420 ENOG4105EJC lysr family transcriptional regulator EA719_014440 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EA719_014460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EA719_014465 ENOG4105C34 Pseudouridine synthase EA719_014470 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EA719_014475 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EA719_014490 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) EA719_014520 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EA719_014550 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EA719_014560 ENOG4105DWF phosphomethylpyrimidine kinase EA719_014565 ENOG4109066 lysm domain bon superfamily protein EA719_014575 ENOG4105CHR reductase EA719_014580 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EA719_014590 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EA719_014595 ENOG4108BPE -transporting atpase EA719_014600 ENOG4107RTD sua5 ycio yrdc ywlc family protein EA719_014605 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EA719_014610 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EA719_014615 ENOG4105FE9 pseudouridine synthase EA719_014625 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EA719_014630 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EA719_014640 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EA719_014645 ENOG4108K4C ec 3.1.3.12 EA719_014650 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase EA719_014655 ENOG4106UW1 Major Facilitator superfamily EA719_014675 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EA719_014685 ENOG4105HF0 Membrane EA719_014700 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EA719_014710 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EA719_014770 ENOG4105D1F ATP-binding protein EA719_014780 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EA719_014810 ENOG4105K6H D-cysteine desulfhydrase EA719_014815 ENOG4105CBX hi0933 family EA719_014840 ENOG4105DP0 ferredoxin-NADP reductase EA719_014845 ENOG4105DUM transcriptional regulator, lysR family EA719_014865 ENOG4105C8S subunit m EA719_014870 ENOG4105D65 subunit l EA719_014880 ENOG4107UFS subunit j EA719_014895 ENOG4108IEH NADH dehydrogenase subunit g EA719_014900 ENOG4107QIZ NADH dehydrogenase EA719_014905 ENOG4105GKE subunit e EA719_014925 ENOG4105BZU Histidine kinase EA719_014935 ENOG4105E0F Histidine kinase EA719_014940 ENOG4107EXC regulatoR EA719_014950 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EA719_014960 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EA719_014970 ENOG4105EB3 Histidine kinase EA719_015040 ENOG4105DZG Dehydrogenase EA719_015060 ENOG4105JAB phenazine biosynthesis protein, phzf family EA719_015090 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EA719_015095 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EA719_015105 ENOG4105ETT transcriptional Regulator, LysR family EA719_015125 ENOG4105CH2 amidohydrolase EA719_015135 ENOG4106P55 Transcriptional regulator EA719_015155 ENOG4106P55 Transcriptional regulator EA719_015160 ENOG4107EFR Flavocytochrome c EA719_015170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EA719_015175 ENOG4107RGD Major Facilitator superfamily EA719_015180 ENOG4105C1G acyl-Coa dehydrogenase EA719_015185 ENOG4105ETT transcriptional Regulator, LysR family EA719_015220 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EA719_015225 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EA719_015230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EA719_015245 ENOG4105VR0 copper resistance EA719_015250 ENOG4105E3B Multicopper oxidase EA719_015260 ENOG4108HCJ Hydrolase EA719_015265 ENOG4105DJV ribulose-phosphate 3-epimerase EA719_015290 ENOG41072GX Peptidase M22 Glycoprotease EA719_015295 ENOG4108Z0R Transferase EA719_015350 ENOG4105CRQ synthase (Component I) EA719_015360 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EA719_015365 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EA719_015370 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EA719_015440 ENOG4105K56 Transcriptional regulator EA719_015445 ENOG4108ZHJ Organic hydroperoxide resistance protein EA719_015450 ENOG4107QHF type ii secretion system protein e EA719_015470 ENOG4105C2M dna polymerase I EA719_015475 ENOG4108VIA integral membrane protein EA719_015480 ENOG4105II7 pyrroline-5-carboxylate reductase EA719_015485 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EA719_015495 ENOG4105C9X ppx gppa phosphatase EA719_015505 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EA719_015525 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EA719_015550 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EA719_015565 ENOG4105W39 Membrane EA719_015570 ENOG4105CYM Glutathione S-transferase EA719_015590 ENOG4105CEY Amp-dependent synthetase and ligase EA719_015595 ENOG4105N42 UPF0307 protein EA719_015600 ENOG41080Z8 PHOSPHOCARRIER protein EA719_015620 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EA719_015625 ENOG4105DJ0 Poly(A) Polymerase EA719_015630 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EA719_015635 ENOG4105DXN mazG family EA719_015645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EA719_015660 ENOG4105C6T cysteine synthase EA719_015665 ENOG4105BZU Histidine kinase EA719_015670 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase EA719_015675 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EA719_015680 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EA719_015695 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EA719_015700 ENOG4105W8H transhydrogenase (subunit alpha EA719_015705 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EA719_015710 ENOG4106UX7 integral membrane protein EA719_015725 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EA719_015735 ENOG4107RSM transcriptional regulator EA719_015745 ENOG4105CUZ uba thif-type nad fad binding protein EA719_015755 ENOG4107QM5 aconitate hydratase EA719_015760 ENOG4105F8V Hydrolase, tatD family EA719_015775 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EA719_015800 ENOG4105BZU Histidine kinase EA719_015810 ENOG4108ZP8 Acetolactate synthase small subunit EA719_015815 ENOG4105C7K acetolactate synthase EA719_015840 ENOG4105DJY efflux transporter, rnd family, mfp subunit EA719_015845 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EA719_015850 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EA719_015855 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EA719_015865 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EA719_015870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EA719_015880 ENOG4105VW4 glutaredoxin 3 EA719_015900 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EA719_015905 ENOG4105C2D reductase EA719_015915 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EA719_015945 ENOG4105C84 Histidine ammonia-lyase EA719_015960 ENOG4105CEY Amp-dependent synthetase and ligase EA719_015975 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EA719_015995 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EA719_016015 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) EA719_016035 ENOG4105WVQ Fe-S assembly protein IscX EA719_016050 ENOG4105CN1 protease EA719_016065 ENOG4106HB6 Alpha beta hydrolase EA719_016075 ENOG4105C26 Dehydrogenase EA719_016080 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EA719_016085 ENOG4105C6Z Gluconate EA719_016090 ENOG4108UHU Aldolase EA719_016095 ENOG4105C01 Dihydroxy-acid dehydratase EA719_016100 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EA719_016105 ENOG4108DNC Involved in acetate metabolism (By similarity) EA719_016110 ENOG4107GFK fumarate EA719_016130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EA719_016140 ENOG4108ESX Receptor EA719_016150 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EA719_016160 ENOG4105DWV Homoserine O-trans-acetylase EA719_016260 ENOG4105CIY formyltetrahydrofolate deformylase EA719_016270 ENOG4107RGH Aldehyde dehydrogenase EA719_016275 ENOG4105KDC 50s ribosomal protein l28 EA719_016280 ENOG4105W0E 50S ribosomal protein L33 EA719_016285 ENOG4105CKD glutathione-regulated potassium-efflux system protein EA719_016305 ENOG4105VFU Rna-binding protein EA719_016310 ENOG4105C4R Atp-dependent dna helicase EA719_016325 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EA719_016335 ENOG4105KVH Transcriptional regulator EA719_016345 ENOG41069P5 Protein slyX homolog EA719_016350 ENOG4105C5H ABC transporter EA719_016355 ENOG4105N14 lysine exporter protein LysE YggA EA719_016360 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EA719_016370 ENOG4105CK2 sodium dicarboxylate symporter EA719_016425 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EA719_016450 ENOG4105DUM transcriptional regulator, lysR family EA719_016475 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EA719_016490 ENOG4108W5M transcriptional regulator EA719_016505 ENOG4105D29 Helix-turn-helix type 11 domain protein EA719_016510 ENOG4107XGZ Hydrolase EA719_016515 ENOG4105EI2 Pseudouridine synthase EA719_016525 ENOG4105C03 ribonuclease EA719_016545 ENOG4105CBN LysR family transcriptional regulator EA719_016550 ENOG4105EMU Dehydrogenase EA719_016555 ENOG4105CSA Coproporphyrinogen iii oxidase EA719_016565 ENOG4107QI1 Mate efflux family protein EA719_016575 ENOG4107T8P acyl-Coa dehydrogenase EA719_016620 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EA719_016625 ENOG4105C5X domain protein EA719_016640 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EA719_016650 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EA719_016655 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) EA719_016660 ENOG4108JU5 Magnesium and cobalt efflux protein EA719_016665 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EA719_016670 ENOG4108Z7R Chaperone CsaA EA719_016680 ENOG4108VAU general secretion pathway protein G EA719_016685 ENOG4105D7Q type ii secretion system EA719_016690 ENOG4105C25 Primosomal protein n' EA719_016695 ENOG4105CKD glutathione-regulated potassium-efflux system protein EA719_016700 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EA719_016710 ENOG4105DVC DnaJ domain protein EA719_016715 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) EA719_016720 ENOG4107QUT magnesium and cobalt transport protein CorA EA719_016740 ENOG4107QYX exodeoxyribonuclease v alpha EA719_016745 ENOG4107QKA exodeoxyribonuclease V beta EA719_016750 ENOG4105DSY exodeoxyribonuclease V, gamma EA719_016760 ENOG4105CSR polyphosphate kinase 2 EA719_016770 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EA719_016785 ENOG41061H0 Monooxygenase EA719_016790 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EA719_016805 ENOG4105D65 subunit l EA719_016810 ENOG4108ZE9 Monovalent cation H antiporter subunit C EA719_016815 ENOG4107R4Z monovalent cation h antiporter subunit d EA719_016820 ENOG4105SC1 monovalent cation H antiporter subunit E EA719_016825 ENOG4105W4C monovalent cation H antiporter subunit F EA719_016830 ENOG4105KJM monovalent cation h antiporter subunit g EA719_016845 ENOG4105CHV Transcription elongation factor NusA EA719_016870 ENOG4107EJC Preprotein translocase subunit SecG EA719_016880 ENOG4107QHF type ii secretion system protein e EA719_016895 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EA719_016905 ENOG4105C2N RNA methyltransferase TrmH family group 3 EA719_016920 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EA719_016930 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EA719_016960 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EA719_016965 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EA719_017035 ENOG4107ZXU DSBA oxidoreductase EA719_017050 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EA719_017065 ENOG4105D3Y Na H antiporter EA719_017070 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EA719_017120 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EA719_017125 ENOG4105PM1 preprotein translocase subunit SecE EA719_017165 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EA719_017170 ENOG4105TV9 FHA Domain-Containing protein EA719_017175 ENOG4105GVR general secretion pathway protein D EA719_017190 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS EA719_017215 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EA719_017220 ENOG4108NEV two component transcriptional regulator, LytTR family EA719_017225 ENOG4108HRK Histidine kinase EA719_017240 ENOG4108UTW Plays a role in the regulation of phosphate uptake EA719_017245 ENOG4105DFG type I secretion outer membrane protein EA719_017250 ENOG4108RNG Permease of the drug metabolite transporter EA719_017275 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EA719_017280 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EA719_017285 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EA719_017290 ENOG4105CNI cell division protein FtsW EA719_017305 ENOG4105CE1 Ferrous iron transport protein b EA719_017315 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EA719_017320 ENOG4105T95 Thiol disulfide interChange protein EA719_017325 ENOG4105D6E homoserine dehydrogenase EA719_017335 ENOG41061WM D-Alanyl-D-Alanine EA719_017345 ENOG4107TUY Histidine kinase EA719_017350 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EA719_017355 ENOG4105CN1 protease EA719_017360 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EA719_017365 ENOG4108K5H permease YjgP YjgQ family protein EA719_017405 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EA719_017415 ENOG4105BZU Histidine kinase EA719_017430 ENOG4105C0P Mg chelatase subunit ChlI EA719_017440 ENOG4108R0M Aminoglycoside EA719_017485 ENOG4105CHH sulfate transporter EA719_017530 ENOG4105C0P Mg chelatase subunit ChlI EA719_017535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EA719_017545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EA719_017555 ENOG4105EPF Outer membrane porin EA719_017560 ENOG4105F0N pyrophosphate phospho-hydrolase EA719_017575 ENOG4105CEY Amp-dependent synthetase and ligase EA719_017580 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EA719_017585 ENOG41079KZ Major Facilitator Superfamily EA719_017590 ENOG4105EN6 Membrane EA719_017600 ENOG4105EE5 Membrane protein terC EA719_017605 ENOG4108URH decarboxylase EA719_017620 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EA719_017635 ENOG4105CCT upf0313 protein EA719_017655 ENOG4105CS1 NAD(P)H quinone oxidoreductase EA719_017665 ENOG4105C6T cysteine synthase EA719_017700 ENOG4105Y7M Transcriptional regulator, TetR family EA719_017735 ENOG4105C79 DNA protecting protein DprA EA719_017750 ENOG4108IND Tetr family transcriptional regulator EA719_017755 ENOG4107RTG Major Facilitator superfamily EA719_017765 ENOG4108V06 Glutathione peroxidase EA719_017805 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EA719_017830 ENOG4105FDK ABC transporter EA719_017835 ENOG4105FAV ABC, transporter EA719_017845 ENOG4105EZR dyp-type peroxidase family protein EA719_017855 ENOG4107R1I NAD-dependent malic enzyme EA719_017880 ENOG4105EUB pirin domain protein EA719_017900 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EA719_017905 ENOG4106MP8 UPF0754 membrane protein EA719_017910 ENOG4108VBZ doxx family EA719_017915 ENOG4105DQR SNARE associated Golgi EA719_017930 ENOG4107QJE Chromosome Partitioning Protein EA719_017940 ENOG4107PSF BolA-like protein EA719_017960 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EA719_017985 ENOG4105C1G acyl-Coa dehydrogenase EA719_018010 ENOG4105CSH Transporter EA719_018015 ENOG4105E39 Enoyl-CoA hydratase EA719_018020 ENOG4105E39 Enoyl-CoA hydratase EA719_018025 ENOG4105C1G acyl-Coa dehydrogenase EA719_018035 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EA719_018040 ENOG4105C26 Dehydrogenase EA719_018050 ENOG4105C85 amino acid EA719_018055 ENOG4105C85 amino acid EA719_018060 ENOG4105M4H endoribonuclease L-psp EA719_018075 ENOG4105EW9 transcriptional regulator AsnC family EA719_018100 ENOG4105D3G Pseudouridine synthase EA719_018115 ENOG4108IG5 Transcriptional regulator EA719_018165 ENOG4108I0Z Aconitate hydratase EA719_018170 ENOG4105BZN citrate synthase EA719_018175 ENOG4105CR4 methylisocitrate lyase EA719_018180 ENOG4105DRR Transcriptional regulator, GntR family EA719_018190 ENOG4105CGF Aromatic amino acid aminotransferase EA719_018195 ENOG4105CXG d-lactate dehydrogenase EA719_018205 ENOG41073TP transcriptional regulator EA719_018210 ENOG4105DAA L-lactate EA719_018215 ENOG4107QKV phosphomannomutase EA719_018220 ENOG4105CMR udp-glucose 4-epimerase EA719_018230 ENOG4105C6Y Udp-glucose 6-dehydrogenase EA719_018235 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EA719_018240 ENOG4105D3Q Sugar transferase EA719_018245 ENOG4108RYC glycosyltransferase EA719_018290 ENOG4105F0R Cytidylyltransferase EA719_018295 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EA719_018300 ENOG4105C5E polysaccharide biosynthesis protein EA719_018305 ENOG4107QQG Dehydrogenase EA719_018310 ENOG4105DAY polysaccharide export protein EA719_018320 ENOG4105D75 Capsular exopolysaccharide family EA719_018325 ENOG4108V1T peptidylprolyl cis-trans isomerase EA719_018330 ENOG4108V1T peptidylprolyl cis-trans isomerase EA719_018335 ENOG4105CJR Integral membrane protein (MviN EA719_018340 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EA719_018345 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EA719_018380 ENOG41062JF Transcriptional regulator EA719_018395 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EA719_018400 ENOG4105UBK short-chain dehydrogenase reductase EA719_018415 ENOG4107QZM n-acetylglutamate synthase EA719_018420 ENOG4105GVF (ABC) transporter EA719_018425 ENOG4105GVF (ABC) transporter EA719_018430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EA719_018435 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EA719_018440 ENOG4108VM9 ABC, transporter EA719_018445 ENOG4108R86 Transcriptional regulator EA719_018450 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EA719_018460 ENOG4105DTN riboflavin biosynthesis protein ribF EA719_018465 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EA719_018475 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EA719_018515 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EA719_018570 ENOG4105CVE Lytic murein transglycosylase EA719_018575 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EA719_018580 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EA719_018595 ENOG4105DFU Cell wall formation (By similarity) EA719_018605 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EA719_018610 ENOG4105DU1 integral membrane protein, terc EA719_018620 ENOG4106032 Glutathionylspermidine synthase EA719_018630 ENOG4107QUY Guanine deaminase EA719_018635 ENOG4108UGV hypoxanthine phosphoribosyltransferase EA719_018645 ENOG4105T95 Thiol disulfide interChange protein EA719_018650 ENOG4105PGM cation diffusion facilitator family transporter EA719_018665 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EA719_018680 ENOG4105VG0 50S ribosomal protein l34 EA719_018690 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EA719_018715 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EA719_018750 ENOG4106J5W DNA polymerase III (alpha subunit) EA719_018760 ENOG4105C0B DNA polymerase III (alpha subunit) EA719_018830 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EA719_018835 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EA719_018870 ENOG4107RZZ dna polymerase iii epsilon subunit EA719_018915 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EA719_018925 ENOG4108WUH Transcriptional regulator, TetR family EA719_018935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EA719_018945 ENOG4108I6A alcohol dehydrogenase EA719_018955 ENOG4105C4W S-formylglutathione hydrolase EA719_018980 ENOG4105E2A Dehydrogenase EA719_019050 ENOG4106I9N Immunoglobulin G binding protein A EA719_019065 ENOG4108JA2 transcriptioN-repair coupling factor EA719_019085 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EA719_019265 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EA719_019335 ENOG4105CHH sulfate transporter EA719_019350 ENOG4105F6A helicase EA719_019360 ENOG4108HWY Beta-lactamase