locus-tag	class	description
HWQ22_00100	COG3566	protein conserved in bacteria
HWQ22_00115	COG3567	Phage-associated protein, HI1409 family
HWQ22_00120	COG5410	chromosome segregation
HWQ22_00200	COG4197	protein conserved in bacteria, prophage-related
HWQ22_00205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWQ22_00270	COG0405	Gamma-glutamyltransferase
HWQ22_00275	COG2814	Major facilitator Superfamily
HWQ22_00285	COG2050	protein possibly involved in aromatic compounds catabolism
HWQ22_00300	COG1090	epimerase
HWQ22_00320	COG0420	3'-5' exonuclease activity
HWQ22_00345	COG0735	belongs to the Fur family
HWQ22_00350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWQ22_00370	COG0121	glutamine amidotransferase
HWQ22_00385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWQ22_00395	COG0210	DNA helicase
HWQ22_00400	COG2885	chlorophyll binding
HWQ22_00405	COG0204	Acyl-transferase
HWQ22_00420	COG2894	cell division
HWQ22_00445	COG1280	lysine exporter protein (LysE YggA)
HWQ22_00450	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWQ22_00450	COG1674	ftsk spoiiie
HWQ22_00455	COG0492	ferredoxin-NADP+ reductase activity
HWQ22_00460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HWQ22_00470	COG0456	acetyltransferase
HWQ22_00530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWQ22_00530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HWQ22_00550	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_00570	COG0473	3-isopropylmalate dehydrogenase activity
HWQ22_00575	COG0583	DNA-binding transcription factor activity
HWQ22_00595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ22_00620	COG0564	pseudouridine synthase activity
HWQ22_00630	COG0358	DNA primase activity
HWQ22_00645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HWQ22_00675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWQ22_00705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWQ22_00715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWQ22_00715	COG0351	phosphomethylpyrimidine kinase
HWQ22_00715	COG0352	thiamine-phosphate diphosphorylase activity
HWQ22_00720	COG1652	LysM domain
HWQ22_00745	COG1399	metal-binding, possibly nucleic acid-binding protein
HWQ22_00750	COG3101	peptidyl-lysine hydroxylation
HWQ22_00755	COG0009	L-threonylcarbamoyladenylate synthase
HWQ22_00760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWQ22_00765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWQ22_00780	COG4106	trans-aconitate 2-methyltransferase activity
HWQ22_00795	COG0596	Alpha beta hydrolase
HWQ22_00795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ22_00795	COG2226	methyltransferase
HWQ22_00800	COG1877	trehalose-phosphatase activity
HWQ22_00805	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HWQ22_00810	COG2223	nitrite transmembrane transporter activity
HWQ22_00830	COG1196	nuclear chromosome segregation
HWQ22_00840	COG0730	response to heat
HWQ22_00855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWQ22_00865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWQ22_00915	COG0489	protein tyrosine kinase activity
HWQ22_00925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ22_00925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ22_00955	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HWQ22_00960	COG2081	HI0933 family
HWQ22_00970	COG0668	transmembrane transport
HWQ22_00990	COG0583	DNA-binding transcription factor activity
HWQ22_01010	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWQ22_01015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWQ22_01045	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWQ22_01080	COG2205	protein histidine kinase activity
HWQ22_01085	COG0745	RESPONSE REGULATOR receiver
HWQ22_01105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWQ22_01115	COG2205	protein histidine kinase activity
HWQ22_01185	COG4993	Dehydrogenase
HWQ22_01210	COG0384	phenazine biosynthesis protein PhzF
HWQ22_01225	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_01245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_01260	COG0583	DNA-binding transcription factor activity
HWQ22_01280	COG1473	amidohydrolase
HWQ22_01290	COG0583	DNA-binding transcription factor activity
HWQ22_01305	COG0583	DNA-binding transcription factor activity
HWQ22_01310	COG1053	succinate dehydrogenase
HWQ22_01320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWQ22_01325	COG2814	Major facilitator Superfamily
HWQ22_01330	COG1960	acyl-CoA dehydrogenase activity
HWQ22_01335	COG0583	DNA-binding transcription factor activity
HWQ22_01340	COG1063	alcohol dehydrogenase
HWQ22_01370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWQ22_01375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWQ22_01380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ22_01395	COG3667	copper resistance
HWQ22_01400	COG2132	Multicopper oxidase
HWQ22_01410	COG0561	phosphatase activity
HWQ22_01415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWQ22_01440	COG1214	PFAM Peptidase M22, glycoprotease
HWQ22_01495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWQ22_01505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWQ22_01510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWQ22_01515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWQ22_01575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWQ22_01585	COG1846	Transcriptional regulator
HWQ22_01590	COG1764	response to oxidative stress
HWQ22_01640	COG0037	tRNA processing
HWQ22_01650	COG0248	Ppx GppA phosphatase
HWQ22_01680	COG0072	phenylalanine-tRNA ligase activity
HWQ22_01720	COG1238	metal cluster binding
HWQ22_01725	COG0625	glutathione transferase activity
HWQ22_01740	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_01745	COG3028	Belongs to the UPF0307 family
HWQ22_01750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWQ22_01770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWQ22_01775	COG0617	tRNA 3'-terminal CCA addition
HWQ22_01780	COG1555	photosystem II stabilization
HWQ22_01785	COG3956	TIGRFAM MazG family protein
HWQ22_01795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ22_01815	COG0784	Response regulator, receiver
HWQ22_01815	COG2205	protein histidine kinase activity
HWQ22_01815	COG5002	protein histidine kinase activity
HWQ22_01820	COG1024	Enoyl-CoA hydratase
HWQ22_01825	COG2084	Dehydrogenase
HWQ22_01830	COG3622	Belongs to the hyi family
HWQ22_01860	COG0697	spore germination
HWQ22_01870	COG2814	Major facilitator Superfamily
HWQ22_01875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWQ22_01885	COG0583	DNA-binding transcription factor activity
HWQ22_01895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWQ22_01905	COG0084	hydrolase, TatD family'
HWQ22_01920	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HWQ22_01950	COG0440	acetolactate synthase activity
HWQ22_01955	COG0028	Belongs to the TPP enzyme family
HWQ22_01985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_01990	COG1136	(ABC) transporter
HWQ22_01990	COG0577	efflux transmembrane transporter activity
HWQ22_01995	COG1538	Outer membrane efflux protein
HWQ22_02010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HWQ22_02015	COG1162	GTPase activity
HWQ22_02025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWQ22_02065	COG1426	Protein conserved in bacteria
HWQ22_02100	COG0793	Belongs to the peptidase S41A family
HWQ22_02125	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_02130	COG3265	gluconokinase activity
HWQ22_02140	COG0800	Aldolase
HWQ22_02150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HWQ22_02155	COG0857	belongs to the CobB CobQ family
HWQ22_02155	COG0280	phosphate acetyltransferase
HWQ22_02160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HWQ22_02160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HWQ22_02180	COG0740	serine-type endopeptidase activity
HWQ22_02190	COG4774	siderophore transport
HWQ22_02200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWQ22_02210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ22_02210	COG2813	Specifically methylates the guanine in position
HWQ22_02310	COG0788	formyltetrahydrofolate deformylase activity
HWQ22_02335	COG4651	solute:proton antiporter activity
HWQ22_02335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ22_02355	COG0724	RNA recognition motif
HWQ22_02360	COG0210	DNA helicase
HWQ22_02385	COG1733	regulation of RNA biosynthetic process
HWQ22_02395	COG2900	Belongs to the SlyX family
HWQ22_02405	COG1280	lysine exporter protein (LysE YggA)
HWQ22_02410	COG1560	Kdo2-lipid A biosynthetic process
HWQ22_02420	COG1301	dicarboxylic acid transport
HWQ22_02445	COG0252	asparaginase activity
HWQ22_02475	COG0473	3-isopropylmalate dehydrogenase activity
HWQ22_02530	COG0583	DNA-binding transcription factor activity
HWQ22_02540	COG0625	glutathione transferase activity
HWQ22_02545	COG2378	regulation of single-species biofilm formation
HWQ22_02550	COG0546	phosphoglycolate phosphatase activity
HWQ22_02560	COG1530	ribonuclease E activity
HWQ22_02565	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_02580	COG0583	DNA-binding transcription factor activity
HWQ22_02585	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_02590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWQ22_02600	COG0534	Mate efflux family protein
HWQ22_02615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWQ22_02655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HWQ22_02660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ22_02675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWQ22_02685	COG0644	oxidoreductase
HWQ22_02685	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HWQ22_02695	COG0425	Belongs to the sulfur carrier protein TusA family
HWQ22_02700	COG4535	Mg2 and Co2 transporter CorC
HWQ22_02710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ22_02730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWQ22_02735	COG0475	glutathione-regulated potassium exporter activity
HWQ22_02735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ22_02750	COG0484	heat shock protein binding
HWQ22_02755	COG0789	Transcriptional regulator
HWQ22_02760	COG0598	Magnesium transport protein CorA
HWQ22_02780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWQ22_02785	COG1074	ATP-dependent DNA helicase activity
HWQ22_02790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HWQ22_02810	COG2226	methyltransferase
HWQ22_02820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWQ22_02835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWQ22_02850	COG2111	Na H antiporter
HWQ22_02850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWQ22_02855	COG1006	Multisubunit Na H antiporter MnhC subunit
HWQ22_02860	COG0651	ATP synthesis coupled electron transport
HWQ22_02870	COG2212	antiporter activity
HWQ22_02890	COG0195	Participates in both transcription termination and antitermination
HWQ22_02940	COG0237	dephospho-CoA kinase activity
HWQ22_02950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWQ22_02965	COG0497	DNA recombination
HWQ22_02975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWQ22_03005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ22_03005	COG2169	Transcriptional regulator
HWQ22_03010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWQ22_03065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWQ22_03080	COG0326	Molecular chaperone. Has ATPase activity
HWQ22_03095	COG2056	Na+-H+ antiporter family
HWQ22_03195	COG0546	phosphoglycolate phosphatase activity
HWQ22_03200	COG1716	ATPase activity
HWQ22_03245	COG0181	hydroxymethylbilane synthase activity
HWQ22_03255	COG3275	phosphorelay sensor kinase activity
HWQ22_03280	COG0697	spore germination
HWQ22_03305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWQ22_03310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWQ22_03315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWQ22_03320	COG0772	Belongs to the SEDS family
HWQ22_03345	COG4974	Belongs to the 'phage' integrase family
HWQ22_03350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ22_03360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWQ22_03370	COG2197	response regulator
HWQ22_03385	COG0793	Belongs to the peptidase S41A family
HWQ22_03390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HWQ22_03395	COG0795	lipopolysaccharide-transporting ATPase activity
HWQ22_03435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWQ22_03435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWQ22_03445	COG0004	ammonium transporteR
HWQ22_03450	COG0347	Belongs to the P(II) protein family
HWQ22_03460	COG0606	chelatase, subunit chli
HWQ22_03470	COG0659	secondary active sulfate transmembrane transporter activity
HWQ22_03475	COG0589	response to stress
HWQ22_03515	COG0606	chelatase, subunit chli
HWQ22_03520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_03530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_03545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HWQ22_03560	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_03570	COG0477	Major facilitator Superfamily
HWQ22_03575	COG2860	membrane
HWQ22_03585	COG1253	flavin adenine dinucleotide binding
HWQ22_03595	COG0477	Major facilitator Superfamily
HWQ22_03605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWQ22_03640	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWQ22_03650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWQ22_03685	COG1309	transcriptional regulator
HWQ22_03720	COG0758	DNA mediated transformation
HWQ22_03730	COG0697	spore germination
HWQ22_03735	COG1309	transcriptional regulator
HWQ22_03750	COG0386	Belongs to the glutathione peroxidase family
HWQ22_03815	COG1121	(ABC) transporter
HWQ22_03820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWQ22_03825	COG1280	lysine exporter protein (LysE YggA)
HWQ22_03830	COG2837	iron assimilation
HWQ22_03835	COG0281	malic enzyme
HWQ22_03880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWQ22_03880	COG0519	Catalyzes the synthesis of GMP from XMP
HWQ22_03885	COG4399	Belongs to the UPF0754 family
HWQ22_03890	COG2259	Doxx family
HWQ22_03895	COG0586	Pfam SNARE associated Golgi protein
HWQ22_03910	COG1192	Involved in chromosome partitioning
HWQ22_03920	COG0271	Belongs to the BolA IbaG family
HWQ22_03960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWQ22_03960	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWQ22_03960	COG3321	synthase
HWQ22_03960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWQ22_03965	COG1960	acyl-CoA dehydrogenase activity
HWQ22_03975	COG2197	response regulator
HWQ22_03985	COG3916	Acyl-homoserine-lactone synthase
HWQ22_03990	COG0477	Major facilitator Superfamily
HWQ22_03995	COG1024	Enoyl-CoA hydratase
HWQ22_04000	COG1024	Enoyl-CoA hydratase
HWQ22_04005	COG1960	acyl-CoA dehydrogenase activity
HWQ22_04010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ22_04030	COG1113	amino acid transport
HWQ22_04035	COG1113	amino acid transport
HWQ22_04040	COG0251	oxidation-reduction process
HWQ22_04080	COG0564	pseudouridine synthase activity
HWQ22_04125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWQ22_04140	COG1802	Transcriptional regulator
HWQ22_04150	COG1448	Aminotransferase
HWQ22_04155	COG0277	FAD linked oxidase domain protein
HWQ22_04165	COG2186	Transcriptional regulator
HWQ22_04175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWQ22_04185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWQ22_04200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWQ22_04205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWQ22_04210	COG1216	Glycosyl transferase, family 2
HWQ22_04225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWQ22_04225	COG1215	transferase activity, transferring glycosyl groups
HWQ22_04230	COG1216	Glycosyl transferase, family 2
HWQ22_04230	COG1442	glycosyl transferase family 8
HWQ22_04240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HWQ22_04245	COG1596	polysaccharide export
HWQ22_04270	COG0728	peptidoglycan biosynthetic process
HWQ22_04275	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWQ22_04330	COG0546	phosphoglycolate phosphatase activity
HWQ22_04335	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_04355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_04360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_04365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ22_04370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_04375	COG1116	anion transmembrane transporter activity
HWQ22_04380	COG1309	transcriptional regulator
HWQ22_04385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWQ22_04395	COG0196	riboflavin kinase activity
HWQ22_04400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWQ22_04410	COG1047	Peptidyl-prolyl cis-trans
HWQ22_04450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWQ22_04505	COG2951	lytic endotransglycosylase activity
HWQ22_04510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWQ22_04525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWQ22_04535	COG0671	phosphoesterase, PA-phosphatase related
HWQ22_04540	COG0861	Integral membrane protein TerC family
HWQ22_04550	COG0754	glutathionylspermidine amidase activity
HWQ22_04560	COG0402	S-adenosylhomocysteine deaminase activity
HWQ22_04575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ22_04580	COG1230	cation diffusion facilitator family transporter
HWQ22_04595	COG0706	membrane insertase activity
HWQ22_04620	COG0592	DNA-directed DNA polymerase activity
HWQ22_04630	COG0187	DNA topoisomerase II activity
HWQ22_04640	COG0586	Pfam SNARE associated Golgi protein
HWQ22_04645	COG0488	(ABC) transporter
HWQ22_04670	COG0596	Alpha beta hydrolase
HWQ22_04675	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HWQ22_04680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWQ22_04720	COG0733	neurotransmitter:sodium symporter activity
HWQ22_04730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWQ22_04755	COG0583	DNA-binding transcription factor activity
HWQ22_04760	COG2233	PERMEase
HWQ22_04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_04810	COG2814	Major facilitator Superfamily
HWQ22_04815	COG0656	L-ascorbic acid biosynthetic process
HWQ22_04820	COG0583	DNA-binding transcription factor activity
HWQ22_04835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_04840	COG1064	alcohol dehydrogenase
HWQ22_04845	COG2818	Glycosylase
HWQ22_04860	COG1194	a g-specific adenine glycosylase
HWQ22_04880	COG2983	Belongs to the UPF0260 family
HWQ22_04885	COG2133	pyrroloquinoline quinone binding
HWQ22_04890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWQ22_04895	COG2116	formate transmembrane transporter activity
HWQ22_04915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_04920	COG1335	isochorismatase
HWQ22_04925	COG0385	Bile acid
HWQ22_04930	COG0534	Mate efflux family protein
HWQ22_04935	COG1683	Conserved Protein
HWQ22_04955	COG0625	glutathione transferase activity
HWQ22_04965	COG1113	amino acid transport
HWQ22_04975	COG0523	cobalamin synthesis protein
HWQ22_04985	COG2188	Transcriptional regulator
HWQ22_05015	COG0010	Belongs to the arginase family
HWQ22_05030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWQ22_05050	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HWQ22_05055	COG0732	type I restriction modification DNA specificity domain
HWQ22_05085	COG4584	PFAM Integrase catalytic
HWQ22_05145	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_05150	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HWQ22_05160	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_05210	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWQ22_05220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWQ22_05225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWQ22_05325	COG0534	Mate efflux family protein
HWQ22_05330	COG0436	Aminotransferase
HWQ22_05335	COG2733	membrane
HWQ22_05350	COG2918	glutathione biosynthetic process
HWQ22_05360	COG3501	Rhs element vgr protein
HWQ22_05365	COG0791	NLP P60 protein
HWQ22_05365	COG1388	LysM domain
HWQ22_05380	COG3150	esterase
HWQ22_05390	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_05395	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HWQ22_05405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_05415	COG2233	PERMEase
HWQ22_05420	COG2351	hydroxyisourate hydrolase activity
HWQ22_05455	COG3706	GGDEF domain
HWQ22_05470	COG1393	Belongs to the ArsC family
HWQ22_05475	COG0708	Exodeoxyribonuclease III
HWQ22_05495	COG0189	ligase activity
HWQ22_05515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWQ22_05525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWQ22_05540	COG4942	peptidase
HWQ22_05550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWQ22_05560	COG2119	membrane
HWQ22_05565	COG4774	siderophore transport
HWQ22_05570	COG0426	domain, Protein
HWQ22_05570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_05595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWQ22_05615	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_05620	COG1519	Transferase
HWQ22_05625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWQ22_05630	COG0668	transmembrane transport
HWQ22_05640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ22_05645	COG1335	isochorismatase
HWQ22_05650	COG1522	sequence-specific DNA binding
HWQ22_05655	COG3328	transposase activity
HWQ22_05680	COG2198	Histidine kinase
HWQ22_05680	COG2205	protein histidine kinase activity
HWQ22_05680	COG0784	Response regulator, receiver
HWQ22_05685	COG3162	membrane
HWQ22_05690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ22_05700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_05710	COG3706	GGDEF domain
HWQ22_05720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWQ22_05725	COG1309	transcriptional regulator
HWQ22_05745	COG0352	thiamine-phosphate diphosphorylase activity
HWQ22_05745	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWQ22_05745	COG0351	phosphomethylpyrimidine kinase
HWQ22_05755	COG2814	Major facilitator Superfamily
HWQ22_05770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWQ22_05780	COG1113	amino acid transport
HWQ22_05790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWQ22_05795	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_05805	COG1335	isochorismatase
HWQ22_05835	COG2814	Major facilitator Superfamily
HWQ22_05840	COG0583	DNA-binding transcription factor activity
HWQ22_05860	COG0667	Aldo Keto reductase
HWQ22_05890	COG1733	regulation of RNA biosynthetic process
HWQ22_05895	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_05970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWQ22_05985	COG2329	Antibiotic biosynthesis monooxygenase
HWQ22_06015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWQ22_06045	COG0427	acetyl-CoA hydrolase
HWQ22_06060	COG0745	RESPONSE REGULATOR receiver
HWQ22_06070	COG0659	secondary active sulfate transmembrane transporter activity
HWQ22_06075	COG4221	oxidoreductase activity
HWQ22_06080	COG2873	o-acetylhomoserine
HWQ22_06085	COG0488	(ABC) transporter
HWQ22_06170	COG0833	amino acid
HWQ22_06215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWQ22_06220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWQ22_06235	COG2226	methyltransferase
HWQ22_06285	COG0067	glutamate synthase
HWQ22_06285	COG0069	glutamate synthase activity
HWQ22_06285	COG0070	glutamate synthase
HWQ22_06290	COG0493	'glutamate synthase
HWQ22_06300	COG1704	LemA family
HWQ22_06305	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWQ22_06325	COG3307	-O-antigen
HWQ22_06345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ22_06360	COG0194	GDP metabolic process
HWQ22_06410	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWQ22_06430	COG5380	lipid catabolic process
HWQ22_06435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWQ22_06460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWQ22_06465	COG0277	FAD linked oxidase domain protein
HWQ22_06475	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWQ22_06480	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_06495	COG1289	transmembrane transporter activity
HWQ22_06505	COG0628	permease
HWQ22_06510	COG1192	Involved in chromosome partitioning
HWQ22_06540	COG0833	amino acid
HWQ22_06545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWQ22_06550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWQ22_06560	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_06600	COG0583	DNA-binding transcription factor activity
HWQ22_06645	COG0517	IMP dehydrogenase activity
HWQ22_06650	COG1983	PspC domain protein
HWQ22_06660	COG1960	acyl-CoA dehydrogenase activity
HWQ22_06675	COG0408	coproporphyrinogen oxidase activity
HWQ22_06695	COG0513	Belongs to the DEAD box helicase family
HWQ22_06705	COG1127	ABC transporter
HWQ22_06710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWQ22_06720	COG2854	intermembrane phospholipid transfer
HWQ22_06730	COG0598	Magnesium transport protein CorA
HWQ22_06740	COG0494	nUDIX hydrolase
HWQ22_06745	COG1040	competence protein
HWQ22_06750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWQ22_06770	COG1946	Acyl-CoA thioesterase
HWQ22_06775	COG1301	dicarboxylic acid transport
HWQ22_06790	COG1959	2 iron, 2 sulfur cluster binding
HWQ22_06795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_06795	COG1017	nitric oxide dioxygenase activity
HWQ22_06800	COG0433	COG0433 Predicted ATPase
HWQ22_06805	COG0626	cystathionine gamma-synthase activity
HWQ22_06960	COG1960	acyl-CoA dehydrogenase activity
HWQ22_06965	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HWQ22_06995	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HWQ22_07000	COG0339	signal peptide processing
HWQ22_07005	COG0557	exoribonuclease II activity
HWQ22_07050	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWQ22_07055	COG2169	Transcriptional regulator
HWQ22_07060	COG0697	spore germination
HWQ22_07065	COG1295	ribonuclease BN
HWQ22_07100	COG1702	phosphate starvation-inducible protein PhoH
HWQ22_07110	COG0741	lytic transglycosylase activity
HWQ22_07110	COG1196	nuclear chromosome segregation
HWQ22_07110	COG0739	heme binding
HWQ22_07140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HWQ22_07145	COG1183	phosphatidylcholine synthase activity
HWQ22_07190	COG1960	acyl-CoA dehydrogenase activity
HWQ22_07195	COG1309	transcriptional regulator
HWQ22_07210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWQ22_07215	COG1960	acyl-CoA dehydrogenase activity
HWQ22_07235	COG2969	positive regulation of protein catabolic process
HWQ22_07245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWQ22_07260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWQ22_07265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWQ22_07285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWQ22_07295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ22_07300	COG1408	metallophosphoesterase
HWQ22_07330	COG1061	Type III restriction enzyme res subunit
HWQ22_07405	COG1607	acyl-coa hydrolase
HWQ22_07435	COG2350	Protein conserved in bacteria
HWQ22_07445	COG0613	PHP domain protein
HWQ22_07450	COG3781	membrane
HWQ22_07460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWQ22_07465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWQ22_07475	COG1862	Preprotein translocase
HWQ22_07505	COG2205	protein histidine kinase activity
HWQ22_07510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HWQ22_07530	COG0726	polysaccharide deacetylase
HWQ22_07535	COG0463	Glycosyl transferase, family 2
HWQ22_07540	COG0438	transferase activity, transferring glycosyl groups
HWQ22_07605	COG0625	glutathione transferase activity
HWQ22_07610	COG0583	DNA-binding transcription factor activity
HWQ22_07615	COG1960	acyl-CoA dehydrogenase activity
HWQ22_07620	COG1960	acyl-CoA dehydrogenase activity
HWQ22_07630	COG2205	protein histidine kinase activity
HWQ22_07635	COG0745	RESPONSE REGULATOR receiver
HWQ22_07640	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HWQ22_07660	COG2096	Adenosyltransferase
HWQ22_07710	COG0285	dihydrofolate synthase activity
HWQ22_07730	COG0450	alkyl hydroperoxide reductase
HWQ22_07745	COG0477	Major facilitator Superfamily
HWQ22_07750	COG1272	protein, Hemolysin III
HWQ22_07780	COG0183	Belongs to the thiolase family
HWQ22_07785	COG2207	Transcriptional regulator
HWQ22_07805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_07825	COG0183	Belongs to the thiolase family
HWQ22_07835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWQ22_07835	COG2885	chlorophyll binding
HWQ22_07845	COG1690	Belongs to the RtcB family
HWQ22_07850	COG0833	amino acid
HWQ22_07860	COG2233	PERMEase
HWQ22_07890	COG2094	Belongs to the DNA glycosylase MPG family
HWQ22_07895	COG4772	TonB-dependent receptor
HWQ22_07910	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_07925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ22_07930	COG0354	folic acid binding
HWQ22_07940	COG3189	MarR family transcriptional regulator
HWQ22_07945	COG2824	Alkylphosphonate utilization operon protein PhnA
HWQ22_07950	COG3422	double-strand break repair
HWQ22_07990	COG0840	transmembrane signaling receptor activity
HWQ22_08010	COG5510	response to toxic substance
HWQ22_08020	COG2832	Protein of unknown function (DUF454)
HWQ22_08025	COG1376	ErfK ybiS ycfS ynhG family protein
HWQ22_08065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWQ22_08075	COG1289	transmembrane transporter activity
HWQ22_08080	COG2814	Major facilitator Superfamily
HWQ22_08100	COG1115	amino acid carrier protein
HWQ22_08105	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWQ22_08110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWQ22_08115	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HWQ22_08155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWQ22_08165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWQ22_08170	COG1077	Cell shape determining protein MreB Mrl
HWQ22_08175	COG1792	Involved in formation and maintenance of cell shape
HWQ22_08180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HWQ22_08185	COG0424	maF-like protein
HWQ22_08190	COG1530	ribonuclease E activity
HWQ22_08200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_08210	COG0560	Phosphoserine phosphatase
HWQ22_08220	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_08245	COG2207	Transcriptional regulator
HWQ22_08265	COG1113	amino acid transport
HWQ22_08270	COG2828	Protein conserved in bacteria
HWQ22_08275	COG0142	geranyltranstransferase activity
HWQ22_08280	COG2315	Protein conserved in bacteria
HWQ22_08295	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWQ22_08315	COG2194	sulfuric ester hydrolase activity
HWQ22_08320	COG0745	RESPONSE REGULATOR receiver
HWQ22_08325	COG0642	Histidine kinase
HWQ22_08335	COG0004	ammonium transporteR
HWQ22_08340	COG0583	DNA-binding transcription factor activity
HWQ22_08360	COG0525	valine-tRNA ligase activity
HWQ22_08370	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_08380	COG0393	Putative heavy-metal-binding
HWQ22_08385	COG0393	Putative heavy-metal-binding
HWQ22_08390	COG1538	Outer membrane efflux protein
HWQ22_08400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_08405	COG0671	phosphoesterase, PA-phosphatase related
HWQ22_08435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWQ22_08450	COG1648	precorrin-2 dehydrogenase activity
HWQ22_08450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWQ22_08455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWQ22_08460	COG1733	regulation of RNA biosynthetic process
HWQ22_08470	COG0531	amino acid
HWQ22_08485	COG0321	lipoyl(octanoyl) transferase activity
HWQ22_08490	COG2921	Belongs to the UPF0250 family
HWQ22_08535	COG2009	succinate dehydrogenase
HWQ22_08540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HWQ22_08545	COG1053	succinate dehydrogenase
HWQ22_08550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWQ22_08575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWQ22_08595	COG2354	Protein conserved in bacteria
HWQ22_08600	COG2321	neutral zinc metallopeptidase
HWQ22_08655	COG2843	Capsule synthesis protein
HWQ22_08670	COG0589	response to stress
HWQ22_08690	COG0505	Belongs to the CarA family
HWQ22_08715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWQ22_08720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWQ22_08770	COG0477	Major facilitator Superfamily
HWQ22_08775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWQ22_08790	COG1597	lipid kinase activity
HWQ22_08795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWQ22_08805	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_08835	COG0584	glycerophosphoryl diester phosphodiesterase
HWQ22_08855	COG0741	lytic transglycosylase activity
HWQ22_08875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWQ22_08890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_08915	COG0778	Nitroreductase
HWQ22_08930	COG1929	Belongs to the glycerate kinase type-1 family
HWQ22_08935	COG0243	molybdopterin cofactor binding
HWQ22_08940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWQ22_08945	COG3339	Conserved Protein
HWQ22_08955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HWQ22_08970	COG1113	amino acid transport
HWQ22_08980	COG0019	diaminopimelate decarboxylase activity
HWQ22_08990	COG1280	lysine exporter protein (LysE YggA)
HWQ22_08995	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HWQ22_09025	COG0463	Glycosyl transferase, family 2
HWQ22_09045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_09080	COG4591	ABC-type transport system involved in lipoprotein release permease component
HWQ22_09085	COG1136	(ABC) transporter
HWQ22_09090	COG0658	competence protein
HWQ22_09090	COG2333	competence protein COMEC
HWQ22_09100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWQ22_09100	COG0616	signal peptide processing
HWQ22_09105	COG0596	Alpha beta hydrolase
HWQ22_09110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWQ22_09120	COG0628	permease
HWQ22_09155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWQ22_09175	COG0823	Involved in the tonB-independent uptake of proteins
HWQ22_09195	COG0824	Thioesterase
HWQ22_09200	COG1473	amidohydrolase
HWQ22_09220	COG0047	phosphoribosylformylglycinamidine synthase activity
HWQ22_09220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWQ22_09225	COG2814	Major facilitator Superfamily
HWQ22_09235	COG1024	Enoyl-CoA hydratase
HWQ22_09240	COG1056	cytidyltransferase-related domain
HWQ22_09240	COG1051	belongs to the nudix hydrolase family
HWQ22_09250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWQ22_09265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HWQ22_09280	COG4625	pathogenesis
HWQ22_09290	COG0583	DNA-binding transcription factor activity
HWQ22_09295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HWQ22_09300	COG4208	sulfate ABC transporter
HWQ22_09305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HWQ22_09315	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWQ22_09320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWQ22_09325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWQ22_09345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWQ22_09360	COG0681	Belongs to the peptidase S26 family
HWQ22_09375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWQ22_09385	COG1381	Involved in DNA repair and RecF pathway recombination
HWQ22_09390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HWQ22_09400	COG4221	oxidoreductase activity
HWQ22_09430	COG0436	Aminotransferase
HWQ22_09450	COG0556	nucleotide-excision repair
HWQ22_09505	COG2070	2-Nitropropane dioxygenase
HWQ22_09535	COG1215	transferase activity, transferring glycosyl groups
HWQ22_09550	COG0415	Belongs to the DNA photolyase family
HWQ22_09560	COG1252	NADH dehydrogenase
HWQ22_09565	COG1686	Belongs to the peptidase S11 family
HWQ22_09580	COG1187	pseudouridine synthase activity
HWQ22_09605	COG0477	Major facilitator Superfamily
HWQ22_09610	COG0583	DNA-binding transcription factor activity
HWQ22_09625	COG0612	Peptidase, M16
HWQ22_09650	COG0352	thiamine-phosphate diphosphorylase activity
HWQ22_09685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_09700	COG1309	transcriptional regulator
HWQ22_09710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWQ22_09715	COG0076	glutamate decarboxylase activity
HWQ22_09725	COG1522	sequence-specific DNA binding
HWQ22_09730	COG3961	Belongs to the TPP enzyme family
HWQ22_09735	COG1113	amino acid transport
HWQ22_09740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWQ22_09745	COG0573	inorganic phosphate transmembrane transporter activity
HWQ22_09755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWQ22_09760	COG0616	signal peptide processing
HWQ22_09770	COG3328	transposase activity
HWQ22_09800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWQ22_09805	COG1686	Belongs to the peptidase S11 family
HWQ22_09830	COG0583	DNA-binding transcription factor activity
HWQ22_09835	COG1067	ATP-dependent peptidase activity
HWQ22_09880	COG1966	Carbon starvation protein
HWQ22_09885	COG2879	small protein
HWQ22_09915	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWQ22_09915	COG2508	Transcriptional regulator
HWQ22_09935	COG1113	amino acid transport
HWQ22_09945	COG0583	DNA-binding transcription factor activity
HWQ22_09950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_09955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_09965	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_09970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_09975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWQ22_09975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ22_10010	COG2814	Major facilitator Superfamily
HWQ22_10015	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ22_10025	COG1309	transcriptional regulator
HWQ22_10045	COG1741	Belongs to the pirin family
HWQ22_10055	COG2964	Protein conserved in bacteria
HWQ22_10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_10075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWQ22_10080	COG4605	iron ion homeostasis
HWQ22_10085	COG4604	ABC transporter, ATP-binding protein
HWQ22_10090	COG4607	ABC-type enterochelin transport system periplasmic component
HWQ22_10095	COG4774	siderophore transport
HWQ22_10105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_10110	COG1021	2,3-dihydroxybenzoate-AMP ligase
HWQ22_10115	COG1535	isochorismatase
HWQ22_10115	COG3433	isochorismatase activity
HWQ22_10130	COG1132	(ABC) transporter
HWQ22_10140	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HWQ22_10150	COG1169	isochorismate synthase
HWQ22_10165	COG3739	integral membrane protein
HWQ22_10200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWQ22_10230	COG0308	aminopeptidase N
HWQ22_10235	COG0512	Glutamine amidotransferase of anthranilate synthase
HWQ22_10245	COG3104	oligopeptide transport
HWQ22_10250	COG0174	glutamine synthetase
HWQ22_10260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWQ22_10295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWQ22_10300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWQ22_10305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWQ22_10325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWQ22_10330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWQ22_10335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HWQ22_10350	COG1960	acyl-CoA dehydrogenase activity
HWQ22_10355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWQ22_10360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWQ22_10370	COG2223	nitrite transmembrane transporter activity
HWQ22_10380	COG0024	Methionine aminopeptidase
HWQ22_10385	COG0052	Belongs to the universal ribosomal protein uS2 family
HWQ22_10400	COG2207	Transcriptional regulator
HWQ22_10425	COG2951	lytic endotransglycosylase activity
HWQ22_10430	COG0772	Belongs to the SEDS family
HWQ22_10445	COG0842	Transport permease protein
HWQ22_10450	COG1131	(ABC) transporter
HWQ22_10495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_10510	COG4215	(ABC) transporter
HWQ22_10515	COG4160	amino acid transport
HWQ22_10520	COG4598	ABC transporter
HWQ22_10530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ22_10540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_10555	COG1720	tRNA m6t6A37 methyltransferase activity
HWQ22_10575	COG0745	RESPONSE REGULATOR receiver
HWQ22_10580	COG0642	Histidine kinase
HWQ22_10590	COG0494	nUDIX hydrolase
HWQ22_10600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWQ22_10605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWQ22_10610	COG3139	Protein of unknown function (DUF1315)
HWQ22_10615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWQ22_10620	COG1301	dicarboxylic acid transport
HWQ22_10625	COG1960	acyl-CoA dehydrogenase activity
HWQ22_10630	COG2819	hydrolase of the alpha beta superfamily
HWQ22_10640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWQ22_10650	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWQ22_10655	COG1234	tRNA 3'-trailer cleavage
HWQ22_10685	COG2363	Small membrane protein
HWQ22_10705	COG0513	Belongs to the DEAD box helicase family
HWQ22_10715	COG0778	Nitroreductase
HWQ22_10745	COG1286	toxin biosynthetic process
HWQ22_10770	COG4783	chaperone-mediated protein folding
HWQ22_10775	COG1610	YqeY-like protein
HWQ22_10875	COG3111	PFAM Bacterial OB fold (BOF) protein
HWQ22_10900	COG3243	poly(R)-hydroxyalkanoic acid synthase
HWQ22_10905	COG0786	glutamate:sodium symporter activity
HWQ22_10915	COG2186	Transcriptional regulator
HWQ22_10930	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_10970	COG0477	Major facilitator Superfamily
HWQ22_10995	COG2985	domain, Protein
HWQ22_11005	COG2995	paraquat-inducible protein a
HWQ22_11010	COG3008	intermembrane lipid transfer
HWQ22_11010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWQ22_11020	COG1794	racemase activity, acting on amino acids and derivatives
HWQ22_11095	COG0482	sulfurtransferase activity
HWQ22_11115	COG3173	Aminoglycoside phosphotransferase
HWQ22_11125	COG2433	Pfam Transposase IS66
HWQ22_11165	COG1301	dicarboxylic acid transport
HWQ22_11175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ22_11180	COG2011	ABC-type metal ion transport system permease component
HWQ22_11185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWQ22_11190	COG1464	Belongs to the NlpA lipoprotein family
HWQ22_11195	COG0151	Belongs to the GarS family
HWQ22_11200	COG0138	bifunctional purine biosynthesis protein purh
HWQ22_11205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HWQ22_11235	COG2308	Evidence 4 Homologs of previously reported genes of
HWQ22_11245	COG1305	Transglutaminase-like
HWQ22_11255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWQ22_11260	COG0305	Participates in initiation and elongation during chromosome replication
HWQ22_11285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWQ22_11295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWQ22_11300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWQ22_11325	COG1649	PFAM Uncharacterised BCR, COG1649
HWQ22_11325	COG0726	polysaccharide deacetylase
HWQ22_11330	COG1215	transferase activity, transferring glycosyl groups
HWQ22_11335	COG3658	cytochrome
HWQ22_11345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ22_11360	COG0583	DNA-binding transcription factor activity
HWQ22_11380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_11385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_11400	COG1960	acyl-CoA dehydrogenase activity
HWQ22_11405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ22_11410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_11435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HWQ22_11440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HWQ22_11450	COG2205	protein histidine kinase activity
HWQ22_11455	COG0745	RESPONSE REGULATOR receiver
HWQ22_11460	COG0174	glutamine synthetase
HWQ22_11480	COG0729	surface antigen
HWQ22_11505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWQ22_11510	COG2814	Major facilitator Superfamily
HWQ22_11525	COG0583	DNA-binding transcription factor activity
HWQ22_11540	COG1187	pseudouridine synthase activity
HWQ22_11560	COG0802	atpase or kinase
HWQ22_11565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWQ22_11575	COG1923	regulation of RNA biosynthetic process
HWQ22_11580	COG0697	spore germination
HWQ22_11595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWQ22_11605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWQ22_11610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWQ22_11610	COG0519	Catalyzes the synthesis of GMP from XMP
HWQ22_11615	COG4302	ethanolamine ammonia-lyase activity
HWQ22_11620	COG4303	Ethanolamine ammonia lyase large subunit
HWQ22_11625	COG0531	amino acid
HWQ22_11645	COG1454	alcohol dehydrogenase
HWQ22_11650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWQ22_11660	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HWQ22_11680	COG0308	aminopeptidase N
HWQ22_11710	COG1605	Chorismate mutase
HWQ22_11725	COG1309	transcriptional regulator
HWQ22_11735	COG0668	transmembrane transport
HWQ22_11775	COG4773	Receptor
HWQ22_11795	COG0488	(ABC) transporter
HWQ22_11800	COG0589	response to stress
HWQ22_11825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWQ22_11835	COG3135	benzoate transporter
HWQ22_11840	COG1522	sequence-specific DNA binding
HWQ22_11850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWQ22_11855	COG0583	DNA-binding transcription factor activity
HWQ22_11865	COG0183	Belongs to the thiolase family
HWQ22_11875	COG2030	dehydratase
HWQ22_11895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWQ22_11910	COG0824	Thioesterase
HWQ22_11915	COG1454	alcohol dehydrogenase
HWQ22_11925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWQ22_11945	COG0069	glutamate synthase activity
HWQ22_11965	COG2814	Major facilitator Superfamily
HWQ22_11980	COG0511	ligase activity, forming carbon-carbon bonds
HWQ22_12000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_12000	COG1116	anion transmembrane transporter activity
HWQ22_12005	COG0745	RESPONSE REGULATOR receiver
HWQ22_12015	COG2146	nitrite reductase [NAD(P)H] activity
HWQ22_12015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_12020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_12025	COG0243	molybdopterin cofactor binding
HWQ22_12035	COG0243	molybdopterin cofactor binding
HWQ22_12040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWQ22_12055	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWQ22_12055	COG0315	cyclic pyranopterin monophosphate synthase activity
HWQ22_12060	COG0303	'Molybdopterin
HWQ22_12070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_12075	COG0697	spore germination
HWQ22_12095	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HWQ22_12100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWQ22_12155	COG2204	response regulator
HWQ22_12160	COG3852	Histidine kinase
HWQ22_12180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWQ22_12185	COG0575	Belongs to the CDS family
HWQ22_12220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWQ22_12235	COG2137	regulation of response to DNA damage stimulus
HWQ22_12245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWQ22_12250	COG1011	Hydrolase
HWQ22_12275	COG1522	sequence-specific DNA binding
HWQ22_12285	COG1113	amino acid transport
HWQ22_12300	COG0659	secondary active sulfate transmembrane transporter activity
HWQ22_12305	COG2135	peptidase activity
HWQ22_12320	COG5001	Diguanylate cyclase
HWQ22_12320	COG3300	MHYT domain
HWQ22_12340	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HWQ22_12340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWQ22_12340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWQ22_12345	COG1105	Belongs to the carbohydrate kinase PfkB family
HWQ22_12350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWQ22_12350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWQ22_12380	COG0024	Methionine aminopeptidase
HWQ22_12385	COG0583	DNA-binding transcription factor activity
HWQ22_12395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HWQ22_12400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWQ22_12405	COG0516	GMP reductase activity
HWQ22_12405	COG0517	IMP dehydrogenase activity
HWQ22_12430	COG0552	protein localization to endoplasmic reticulum
HWQ22_12440	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HWQ22_12455	COG4890	Cyd operon protein YbgT
HWQ22_12460	COG1294	oxidase, subunit
HWQ22_12480	COG1585	Membrane protein implicated in regulation of membrane protease activity
HWQ22_12490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWQ22_12495	COG4774	siderophore transport
HWQ22_12510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWQ22_12515	COG0569	domain protein
HWQ22_12520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWQ22_12550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HWQ22_12555	COG0542	response to heat
HWQ22_12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_12580	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_12625	COG2323	membrane
HWQ22_12630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWQ22_12640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ22_12645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_12650	COG0183	Belongs to the thiolase family
HWQ22_12655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWQ22_12660	COG0596	Alpha beta hydrolase
HWQ22_12665	COG2271	Major facilitator Superfamily
HWQ22_12670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ22_12675	COG3485	protocatechuate 3,4-dioxygenase
HWQ22_12680	COG3485	protocatechuate 3,4-dioxygenase
HWQ22_12685	COG0710	3-dehydroquinate dehydratase activity
HWQ22_12690	COG3420	alginic acid biosynthetic process
HWQ22_12695	COG3659	wide pore channel activity
HWQ22_12700	COG4993	Dehydrogenase
HWQ22_12710	COG2391	methyltransferase activity
HWQ22_12725	COG1414	Transcriptional regulator
HWQ22_12730	COG0583	DNA-binding transcription factor activity
HWQ22_12735	COG1960	acyl-CoA dehydrogenase activity
HWQ22_12760	COG2814	Major facilitator Superfamily
HWQ22_12770	COG0154	amidase activity
HWQ22_12790	COG4638	Rieske (2fe-2S)
HWQ22_12800	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_12810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_12820	COG3733	amine oxidase
HWQ22_12830	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_12840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ22_12845	COG0183	Belongs to the thiolase family
HWQ22_12850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_12855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ22_12865	COG4829	muconolactone delta-isomerase
HWQ22_12870	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ22_12875	COG0583	DNA-binding transcription factor activity
HWQ22_12885	COG2186	Transcriptional regulator
HWQ22_12905	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_12925	COG1960	acyl-CoA dehydrogenase activity
HWQ22_12930	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_12935	COG3829	transcription factor binding
HWQ22_12945	COG3162	membrane
HWQ22_12960	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_12975	COG0753	catalase activity
HWQ22_12995	COG1846	Transcriptional regulator
HWQ22_13000	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_13000	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_13010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWQ22_13040	COG1309	transcriptional regulator
HWQ22_13050	COG1335	isochorismatase
HWQ22_13055	COG0583	DNA-binding transcription factor activity
HWQ22_13065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ22_13065	COG0475	glutathione-regulated potassium exporter activity
HWQ22_13075	COG1473	amidohydrolase
HWQ22_13085	COG2831	hemolysin activation secretion protein
HWQ22_13090	COG3210	domain, Protein
HWQ22_13120	COG2188	Transcriptional regulator
HWQ22_13135	COG0583	DNA-binding transcription factor activity
HWQ22_13165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWQ22_13185	COG1566	PFAM secretion protein HlyD family protein
HWQ22_13200	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_13205	COG0129	dihydroxy-acid dehydratase activity
HWQ22_13215	COG0583	DNA-binding transcription factor activity
HWQ22_13220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWQ22_13230	COG2084	Dehydrogenase
HWQ22_13235	COG2207	Transcriptional regulator
HWQ22_13250	COG1064	alcohol dehydrogenase
HWQ22_13265	COG1120	ATPase activity
HWQ22_13285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWQ22_13400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HWQ22_13450	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_13465	COG2207	Transcriptional regulator
HWQ22_13475	COG2205	protein histidine kinase activity
HWQ22_13480	COG0745	RESPONSE REGULATOR receiver
HWQ22_13485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_13490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ22_13495	COG1538	Outer membrane efflux protein
HWQ22_13505	COG2072	flavoprotein involved in K transport
HWQ22_13525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ22_13545	COG3539	Fimbrial protein
HWQ22_13575	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWQ22_13585	COG0753	catalase activity
HWQ22_13600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ22_13665	COG3433	isochorismatase activity
HWQ22_13665	COG1535	isochorismatase
HWQ22_13670	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_13675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HWQ22_13680	COG4149	molybdate abc transporter
HWQ22_13685	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWQ22_13695	COG4638	Rieske (2fe-2S)
HWQ22_13700	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWQ22_13705	COG0543	2 iron, 2 sulfur cluster binding
HWQ22_13705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_13730	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_13745	COG2207	Transcriptional regulator
HWQ22_13755	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_13760	COG2610	gluconate transmembrane transporter activity
HWQ22_13770	COG0583	DNA-binding transcription factor activity
HWQ22_13785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_13790	COG2031	fatty acid transporter
HWQ22_13795	COG0183	Belongs to the thiolase family
HWQ22_13800	COG0583	DNA-binding transcription factor activity
HWQ22_13805	COG0583	DNA-binding transcription factor activity
HWQ22_13820	COG1027	Aspartate ammonia-lyase
HWQ22_13830	COG0477	Major facilitator Superfamily
HWQ22_13850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_13855	COG4521	taurine ABC transporter
HWQ22_13870	COG2188	Transcriptional regulator
HWQ22_13880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWQ22_13885	COG1733	regulation of RNA biosynthetic process
HWQ22_13890	COG3708	Transcriptional regulator
HWQ22_13890	COG2207	Transcriptional regulator
HWQ22_13905	COG0730	response to heat
HWQ22_13915	COG3453	Protein conserved in bacteria
HWQ22_13915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ22_13925	COG3781	membrane
HWQ22_13930	COG1063	alcohol dehydrogenase
HWQ22_13940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWQ22_13945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWQ22_13950	COG0022	dehydrogenase e1 component
HWQ22_13955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWQ22_13960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWQ22_13975	COG3706	GGDEF domain
HWQ22_13990	COG0133	tryptophan synthase activity
HWQ22_14000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWQ22_14035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWQ22_14060	COG2226	methyltransferase
HWQ22_14115	COG0842	Transport permease protein
HWQ22_14120	COG0842	Transport permease protein
HWQ22_14125	COG1131	(ABC) transporter
HWQ22_14140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWQ22_14145	COG4773	Receptor
HWQ22_14165	COG0730	response to heat
HWQ22_14170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HWQ22_14190	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWQ22_14205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWQ22_14245	COG4264	IucA IucC family
HWQ22_14250	COG4264	IucA IucC family
HWQ22_14270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWQ22_14285	COG1960	acyl-CoA dehydrogenase activity
HWQ22_14290	COG1960	acyl-CoA dehydrogenase activity
HWQ22_14295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ22_14300	COG2207	Transcriptional regulator
HWQ22_14305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ22_14310	COG0776	regulation of translation
HWQ22_14335	COG0822	iron-sulfur transferase activity
HWQ22_14340	COG0316	Belongs to the HesB IscA family
HWQ22_14370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWQ22_14390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWQ22_14395	COG0702	epimerase
HWQ22_14430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWQ22_14440	COG0339	signal peptide processing
HWQ22_14490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HWQ22_14495	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWQ22_14525	COG0776	regulation of translation
HWQ22_14590	COG0084	hydrolase, TatD family'
HWQ22_14610	COG1663	tetraacyldisaccharide 4'-kinase activity
HWQ22_14615	COG1132	(ABC) transporter
HWQ22_14625	COG0811	peptide transport
HWQ22_14630	COG1475	DNA binding
HWQ22_14635	COG1192	Involved in chromosome partitioning
HWQ22_14645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWQ22_14660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ22_14665	COG0191	fructose-bisphosphate aldolase activity
HWQ22_14685	COG0424	maF-like protein
HWQ22_14690	COG2850	peptidyl-arginine hydroxylation
HWQ22_14700	COG0640	Transcriptional regulator
HWQ22_14715	COG3619	membrane
HWQ22_14720	COG3122	Protein conserved in bacteria
HWQ22_14725	COG1132	(ABC) transporter
HWQ22_14745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWQ22_14750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ22_14760	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWQ22_14760	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWQ22_14760	COG0506	proline dehydrogenase activity
HWQ22_14765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWQ22_14780	COG3698	Phosphodiester glycosidase
HWQ22_14790	COG2353	YceI-like domain
HWQ22_14800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWQ22_14845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HWQ22_14845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWQ22_14870	COG3539	Fimbrial protein
HWQ22_14875	COG3121	Chaperone
HWQ22_14900	COG0697	spore germination
HWQ22_14910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWQ22_14920	COG0583	DNA-binding transcription factor activity
HWQ22_14940	COG1309	transcriptional regulator
HWQ22_14955	COG1522	sequence-specific DNA binding
HWQ22_14965	COG1126	abc transporter atp-binding protein
HWQ22_14970	COG0765	amino acid transport
HWQ22_14975	COG0765	amino acid transport
HWQ22_15005	COG1464	Belongs to the NlpA lipoprotein family
HWQ22_15015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWQ22_15020	COG2011	ABC-type metal ion transport system permease component
HWQ22_15025	COG0012	GTP binding
HWQ22_15050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWQ22_15090	COG0386	Belongs to the glutathione peroxidase family
HWQ22_15100	COG0436	Aminotransferase
HWQ22_15140	COG3634	alkyl hydroperoxide reductase activity
HWQ22_15155	COG0583	DNA-binding transcription factor activity
HWQ22_15160	COG0798	PFAM Bile acid sodium symporter
HWQ22_15165	COG0640	Transcriptional regulator
HWQ22_15180	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWQ22_15190	COG0583	DNA-binding transcription factor activity
HWQ22_15200	COG1953	Uracil, thiamine, allantoin
HWQ22_15210	COG2175	clavaminate synthase activity
HWQ22_15215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_15220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HWQ22_15225	COG4521	taurine ABC transporter
HWQ22_15240	COG0477	Major facilitator Superfamily
HWQ22_15260	COG1271	oxidase subunit
HWQ22_15265	COG1294	oxidase, subunit
HWQ22_15275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_15295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWQ22_15315	COG3052	prosthetic group binding
HWQ22_15320	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HWQ22_15330	COG2814	Major facilitator Superfamily
HWQ22_15350	COG1346	cytolysis
HWQ22_15360	COG0583	DNA-binding transcription factor activity
HWQ22_15365	COG0625	glutathione transferase activity
HWQ22_15370	COG0625	glutathione transferase activity
HWQ22_15375	COG0583	DNA-binding transcription factor activity
HWQ22_15390	COG1045	serine acetyltransferase
HWQ22_15395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWQ22_15400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWQ22_15410	COG1280	lysine exporter protein (LysE YggA)
HWQ22_15425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ22_15430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ22_15435	COG1126	abc transporter atp-binding protein
HWQ22_15440	COG0765	amino acid transport
HWQ22_15445	COG0765	amino acid transport
HWQ22_15465	COG2205	protein histidine kinase activity
HWQ22_15465	COG0784	Response regulator, receiver
HWQ22_15485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWQ22_15505	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_15555	COG0583	DNA-binding transcription factor activity
HWQ22_15575	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_15580	COG1309	transcriptional regulator
HWQ22_15585	COG1960	acyl-CoA dehydrogenase activity
HWQ22_15590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWQ22_15595	COG1024	Enoyl-CoA hydratase
HWQ22_15600	COG4770	biotin carboxylase activity
HWQ22_15610	COG0583	DNA-binding transcription factor activity
HWQ22_15625	COG1960	acyl-CoA dehydrogenase activity
HWQ22_15635	COG2814	Major facilitator Superfamily
HWQ22_15645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_15650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ22_15655	COG2814	Major facilitator Superfamily
HWQ22_15660	COG1960	acyl-CoA dehydrogenase activity
HWQ22_15665	COG1024	Enoyl-CoA hydratase
HWQ22_15670	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_15675	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ22_15680	COG0183	Belongs to the thiolase family
HWQ22_15690	COG2814	Major facilitator Superfamily
HWQ22_15700	COG1024	Enoyl-CoA hydratase
HWQ22_15715	COG1960	acyl-CoA dehydrogenase activity
HWQ22_15720	COG2814	Major facilitator Superfamily
HWQ22_15725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWQ22_15730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HWQ22_15745	COG3842	ATPase activity
HWQ22_15750	COG1840	ABC-type Fe3 transport system, periplasmic component
HWQ22_15760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_15765	COG1414	Transcriptional regulator
HWQ22_15775	COG0583	DNA-binding transcription factor activity
HWQ22_15780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ22_15785	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_15795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWQ22_15805	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_15810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ22_15815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_15820	COG2267	carboxylic ester hydrolase activity
HWQ22_15840	COG3038	cytochrome b561
HWQ22_15845	COG0753	catalase activity
HWQ22_15880	COG2050	protein possibly involved in aromatic compounds catabolism
HWQ22_15890	COG3327	negative regulation of DNA-templated transcription, initiation
HWQ22_15895	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HWQ22_15900	COG0183	Belongs to the thiolase family
HWQ22_15905	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ22_15910	COG1024	Enoyl-CoA hydratase
HWQ22_15915	COG1024	Enoyl-CoA hydratase
HWQ22_15920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_15925	COG2151	metal-sulfur cluster biosynthetic enzyme
HWQ22_15930	COG3396	Phenylacetate-CoA oxygenase
HWQ22_15935	COG3460	Phenylacetate-CoA oxygenase
HWQ22_15940	COG3396	Phenylacetate-CoA oxygenase
HWQ22_15945	COG2030	dehydratase
HWQ22_15945	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_15950	COG1760	l-serine dehydratase
HWQ22_15955	COG0531	amino acid
HWQ22_15960	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_15975	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_15985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ22_16005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_16015	COG0789	Transcriptional regulator
HWQ22_16030	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWQ22_16045	COG2807	transmembrane transport
HWQ22_16050	COG0590	tRNA wobble adenosine to inosine editing
HWQ22_16165	COG1116	anion transmembrane transporter activity
HWQ22_16170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ22_16180	COG0864	Transcriptional regulator
HWQ22_16200	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_16205	COG0439	Biotin carboxylase
HWQ22_16220	COG1063	alcohol dehydrogenase
HWQ22_16230	COG1309	transcriptional regulator
HWQ22_16250	COG0038	chloride channel
HWQ22_16255	COG4770	biotin carboxylase activity
HWQ22_16275	COG1914	H( )-stimulated, divalent metal cation uptake system
HWQ22_16280	COG0583	DNA-binding transcription factor activity
HWQ22_16295	COG3209	COG3209 Rhs family protein
HWQ22_16300	COG3501	Rhs element vgr protein
HWQ22_16330	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ22_16350	COG2814	Major facilitator Superfamily
HWQ22_16360	COG1560	Kdo2-lipid A biosynthetic process
HWQ22_16370	COG5006	permease, DMT superfamily
HWQ22_16375	COG1522	sequence-specific DNA binding
HWQ22_16390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWQ22_16400	COG4122	O-methyltransferase activity
HWQ22_16430	COG1538	Outer membrane efflux protein
HWQ22_16435	COG1137	ATPase activity
HWQ22_16440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HWQ22_16450	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HWQ22_16455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWQ22_16455	COG0517	IMP dehydrogenase activity
HWQ22_16490	COG2814	Major facilitator Superfamily
HWQ22_16525	COG1278	Cold shock
HWQ22_16530	COG1280	lysine exporter protein (LysE YggA)
HWQ22_16565	COG1570	exodeoxyribonuclease VII activity
HWQ22_16615	COG0583	DNA-binding transcription factor activity
HWQ22_16620	COG4638	Rieske (2fe-2S)
HWQ22_16625	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWQ22_16630	COG0633	Ferredoxin
HWQ22_16630	COG0543	2 iron, 2 sulfur cluster binding
HWQ22_16635	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_16640	COG3135	benzoate transporter
HWQ22_16645	COG2814	Major facilitator Superfamily
HWQ22_16660	COG1643	Atp-dependent helicase
HWQ22_16665	COG0450	alkyl hydroperoxide reductase
HWQ22_16675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWQ22_16685	COG3634	alkyl hydroperoxide reductase activity
HWQ22_16705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWQ22_16710	COG0625	glutathione transferase activity
HWQ22_16720	COG2885	chlorophyll binding
HWQ22_16755	COG0542	response to heat
HWQ22_16770	COG1765	OsmC-like protein
HWQ22_16785	COG0667	Aldo Keto reductase
HWQ22_16800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HWQ22_16810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWQ22_16820	COG0527	aspartate kinase activity
HWQ22_16830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWQ22_16840	COG3038	cytochrome b561
HWQ22_16845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWQ22_16850	COG2252	PERMEase
HWQ22_16860	COG2072	flavoprotein involved in K transport
HWQ22_16875	COG1741	Belongs to the pirin family
HWQ22_16880	COG1309	transcriptional regulator
HWQ22_16905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWQ22_16945	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_16945	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_16955	COG5001	Diguanylate cyclase
HWQ22_16955	COG4251	negative regulation of phosphorylation
HWQ22_16955	COG3706	GGDEF domain
HWQ22_16955	COG2203	Gaf domain
HWQ22_16965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWQ22_16985	COG4172	Belongs to the ABC transporter superfamily
HWQ22_16990	COG4239	(ABC) transporter, permease
HWQ22_16995	COG4174	ABC transporter (Permease)
HWQ22_17005	COG0741	lytic transglycosylase activity
HWQ22_17005	COG1388	LysM domain
HWQ22_17005	COG1388	LysM domain
HWQ22_17005	COG0741	lytic transglycosylase activity
HWQ22_17010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWQ22_17050	COG0583	DNA-binding transcription factor activity
HWQ22_17055	COG1279	arginine transmembrane transporter activity
HWQ22_17075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_17080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_17085	COG0006	proline dipeptidase activity
HWQ22_17120	COG2194	sulfuric ester hydrolase activity
HWQ22_17165	COG0739	heme binding
HWQ22_17490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWQ22_17515	COG3384	dioxygenase
HWQ22_17525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWQ22_17530	COG2878	Part of a membrane complex involved in electron transport
HWQ22_17535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWQ22_17560	COG0768	penicillin binding
HWQ22_17565	COG0742	ribosomal rna small subunit methyltransferase
HWQ22_17580	COG0830	nickel cation binding
HWQ22_17590	COG0804	urea catabolic process
HWQ22_17630	COG1253	flavin adenine dinucleotide binding
HWQ22_17635	COG2851	Citrate transporter
HWQ22_17690	COG1773	rubredoxin
HWQ22_17695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_17705	COG0583	DNA-binding transcription factor activity
HWQ22_17730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HWQ22_17735	COG4181	ATPase activity
HWQ22_17780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWQ22_17800	COG0306	phosphate transporter
HWQ22_17810	COG3958	Transketolase
HWQ22_17815	COG3959	Transketolase, thiamine diphosphate binding domain
HWQ22_17820	COG2271	Major facilitator Superfamily
HWQ22_17825	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_17830	COG0583	DNA-binding transcription factor activity
HWQ22_17845	COG2223	nitrite transmembrane transporter activity
HWQ22_17850	COG2207	Transcriptional regulator
HWQ22_17855	COG2066	Belongs to the glutaminase family
HWQ22_17860	COG0242	peptide deformylase activity
HWQ22_17865	COG0477	Major facilitator Superfamily
HWQ22_17875	COG0028	Belongs to the TPP enzyme family
HWQ22_17890	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_17895	COG2267	carboxylic ester hydrolase activity
HWQ22_17905	COG2271	Major facilitator Superfamily
HWQ22_17910	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_17920	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_17940	COG1414	Transcriptional regulator
HWQ22_17955	COG1024	Enoyl-CoA hydratase
HWQ22_17965	COG1215	transferase activity, transferring glycosyl groups
HWQ22_17970	COG1649	PFAM Uncharacterised BCR, COG1649
HWQ22_17970	COG0726	polysaccharide deacetylase
HWQ22_17980	COG4681	YaeQ
HWQ22_17990	COG0523	cobalamin synthesis protein
HWQ22_18000	COG1607	acyl-coa hydrolase
HWQ22_18010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_18015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_18020	COG1309	transcriptional regulator
HWQ22_18045	COG2040	homocysteine
HWQ22_18050	COG0531	amino acid
HWQ22_18105	COG1595	DNA-templated transcription, initiation
HWQ22_18115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_18120	COG0477	Major facilitator Superfamily
HWQ22_18140	COG0084	hydrolase, TatD family'
HWQ22_18175	COG0629	single-stranded DNA binding
HWQ22_18230	COG0582	viral genome integration into host DNA
HWQ22_18245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair