locus-tag	class	description
H5029_00010	COG0592	DNA-directed DNA polymerase activity
H5029_00020	COG0187	DNA topoisomerase II activity
H5029_00030	COG0586	Pfam SNARE associated Golgi protein
H5029_00035	COG0488	(ABC) transporter
H5029_00060	COG0596	Alpha beta hydrolase
H5029_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5029_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5029_00110	COG0733	neurotransmitter:sodium symporter activity
H5029_00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5029_00145	COG0583	DNA-binding transcription factor activity
H5029_00150	COG2233	PERMEase
H5029_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_00200	COG2814	Major facilitator Superfamily
H5029_00205	COG0656	L-ascorbic acid biosynthetic process
H5029_00210	COG0583	DNA-binding transcription factor activity
H5029_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_00230	COG1064	alcohol dehydrogenase
H5029_00235	COG2818	Glycosylase
H5029_00250	COG1194	a g-specific adenine glycosylase
H5029_00270	COG2983	Belongs to the UPF0260 family
H5029_00275	COG2133	pyrroloquinoline quinone binding
H5029_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5029_00285	COG2116	formate transmembrane transporter activity
H5029_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_00310	COG1335	isochorismatase
H5029_00315	COG0385	Bile acid
H5029_00320	COG0534	Mate efflux family protein
H5029_00325	COG1683	Conserved Protein
H5029_00345	COG0625	glutathione transferase activity
H5029_00355	COG1113	amino acid transport
H5029_00365	COG0523	cobalamin synthesis protein
H5029_00375	COG2188	Transcriptional regulator
H5029_00405	COG0010	Belongs to the arginase family
H5029_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5029_00440	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H5029_00445	COG0732	type I restriction modification DNA specificity domain
H5029_00475	COG4584	PFAM Integrase catalytic
H5029_00505	COG2826	transposase and inactivated derivatives, IS30 family
H5029_00525	COG0673	inositol 2-dehydrogenase activity
H5029_00530	COG1324	tolerance protein
H5029_00575	COG2826	transposase and inactivated derivatives, IS30 family
H5029_00580	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H5029_00590	COG2826	transposase and inactivated derivatives, IS30 family
H5029_00640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5029_00650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5029_00655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5029_00755	COG0534	Mate efflux family protein
H5029_00760	COG0436	Aminotransferase
H5029_00765	COG2733	membrane
H5029_00780	COG2918	glutathione biosynthetic process
H5029_00795	COG0791	NLP P60 protein
H5029_00795	COG1388	LysM domain
H5029_00810	COG3150	esterase
H5029_00820	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_00825	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H5029_00835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_00845	COG2233	PERMEase
H5029_00850	COG2351	hydroxyisourate hydrolase activity
H5029_00885	COG3706	GGDEF domain
H5029_00900	COG1393	Belongs to the ArsC family
H5029_00905	COG0708	Exodeoxyribonuclease III
H5029_00925	COG0189	ligase activity
H5029_00945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5029_00955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5029_00970	COG4942	peptidase
H5029_00980	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5029_00990	COG2119	membrane
H5029_00995	COG4774	siderophore transport
H5029_01000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_01000	COG0426	domain, Protein
H5029_01025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5029_01045	COG1902	pentaerythritol trinitrate reductase activity
H5029_01050	COG1519	Transferase
H5029_01055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5029_01060	COG0668	transmembrane transport
H5029_01070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5029_01075	COG1335	isochorismatase
H5029_01080	COG1522	sequence-specific DNA binding
H5029_01110	COG0784	Response regulator, receiver
H5029_01110	COG2198	Histidine kinase
H5029_01110	COG2205	protein histidine kinase activity
H5029_01115	COG3162	membrane
H5029_01120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5029_01130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_01150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5029_01155	COG1309	transcriptional regulator
H5029_01175	COG0351	phosphomethylpyrimidine kinase
H5029_01175	COG0352	thiamine-phosphate diphosphorylase activity
H5029_01175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5029_01185	COG2814	Major facilitator Superfamily
H5029_01200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5029_01210	COG1113	amino acid transport
H5029_01220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5029_01225	COG1012	belongs to the aldehyde dehydrogenase family
H5029_01235	COG1335	isochorismatase
H5029_01265	COG2814	Major facilitator Superfamily
H5029_01270	COG0583	DNA-binding transcription factor activity
H5029_01290	COG0667	Aldo Keto reductase
H5029_01325	COG1733	regulation of RNA biosynthetic process
H5029_01330	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_01405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5029_01420	COG2329	Antibiotic biosynthesis monooxygenase
H5029_01450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5029_01480	COG0427	acetyl-CoA hydrolase
H5029_01505	COG0659	secondary active sulfate transmembrane transporter activity
H5029_01510	COG4221	oxidoreductase activity
H5029_01515	COG2873	o-acetylhomoserine
H5029_01520	COG0488	(ABC) transporter
H5029_01605	COG0833	amino acid
H5029_01650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5029_01655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5029_01670	COG2226	methyltransferase
H5029_01720	COG0067	glutamate synthase
H5029_01720	COG0070	glutamate synthase
H5029_01720	COG0069	glutamate synthase activity
H5029_01725	COG0493	'glutamate synthase
H5029_01735	COG1704	LemA family
H5029_01740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H5029_01760	COG3307	-O-antigen
H5029_01780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5029_01795	COG0194	GDP metabolic process
H5029_01845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5029_01865	COG5380	lipid catabolic process
H5029_01870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5029_01895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5029_01900	COG0277	FAD linked oxidase domain protein
H5029_01910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5029_01915	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_01930	COG1289	transmembrane transporter activity
H5029_01940	COG0628	permease
H5029_01945	COG1192	Involved in chromosome partitioning
H5029_01975	COG0833	amino acid
H5029_01980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5029_01985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5029_01995	COG1012	belongs to the aldehyde dehydrogenase family
H5029_02035	COG0583	DNA-binding transcription factor activity
H5029_02080	COG0517	IMP dehydrogenase activity
H5029_02085	COG1983	PspC domain protein
H5029_02095	COG1960	acyl-CoA dehydrogenase activity
H5029_02110	COG0408	coproporphyrinogen oxidase activity
H5029_02130	COG0513	Belongs to the DEAD box helicase family
H5029_02140	COG1127	ABC transporter
H5029_02145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5029_02155	COG2854	intermembrane phospholipid transfer
H5029_02165	COG0598	Magnesium transport protein CorA
H5029_02175	COG0494	nUDIX hydrolase
H5029_02180	COG1040	competence protein
H5029_02185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5029_02205	COG1946	Acyl-CoA thioesterase
H5029_02210	COG1301	dicarboxylic acid transport
H5029_02225	COG1959	2 iron, 2 sulfur cluster binding
H5029_02230	COG1017	nitric oxide dioxygenase activity
H5029_02230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_02235	COG0433	COG0433 Predicted ATPase
H5029_02240	COG0626	cystathionine gamma-synthase activity
H5029_02395	COG1960	acyl-CoA dehydrogenase activity
H5029_02400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5029_02430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H5029_02435	COG0339	signal peptide processing
H5029_02440	COG0557	exoribonuclease II activity
H5029_02485	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5029_02490	COG2169	Transcriptional regulator
H5029_02495	COG0697	spore germination
H5029_02500	COG1295	ribonuclease BN
H5029_02535	COG1702	phosphate starvation-inducible protein PhoH
H5029_02545	COG1196	nuclear chromosome segregation
H5029_02545	COG0741	lytic transglycosylase activity
H5029_02545	COG0739	heme binding
H5029_02575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5029_02580	COG1183	phosphatidylcholine synthase activity
H5029_02625	COG1960	acyl-CoA dehydrogenase activity
H5029_02630	COG1309	transcriptional regulator
H5029_02645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5029_02650	COG1960	acyl-CoA dehydrogenase activity
H5029_02670	COG2969	positive regulation of protein catabolic process
H5029_02680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5029_02695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5029_02700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5029_02720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5029_02730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5029_02735	COG1408	metallophosphoesterase
H5029_02765	COG1061	Type III restriction enzyme res subunit
H5029_02840	COG1607	acyl-coa hydrolase
H5029_02870	COG2350	Protein conserved in bacteria
H5029_02880	COG0613	PHP domain protein
H5029_02885	COG3781	membrane
H5029_02895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5029_02900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5029_02910	COG1862	Preprotein translocase
H5029_02940	COG2205	protein histidine kinase activity
H5029_02945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5029_02965	COG0726	polysaccharide deacetylase
H5029_02970	COG0463	Glycosyl transferase, family 2
H5029_02975	COG0438	transferase activity, transferring glycosyl groups
H5029_03040	COG0625	glutathione transferase activity
H5029_03045	COG0583	DNA-binding transcription factor activity
H5029_03050	COG1960	acyl-CoA dehydrogenase activity
H5029_03055	COG1960	acyl-CoA dehydrogenase activity
H5029_03065	COG2205	protein histidine kinase activity
H5029_03070	COG0745	RESPONSE REGULATOR receiver
H5029_03075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5029_03095	COG2096	Adenosyltransferase
H5029_03145	COG0285	dihydrofolate synthase activity
H5029_03165	COG0450	alkyl hydroperoxide reductase
H5029_03180	COG0477	Major facilitator Superfamily
H5029_03185	COG1272	protein, Hemolysin III
H5029_03215	COG0183	Belongs to the thiolase family
H5029_03220	COG2207	Transcriptional regulator
H5029_03240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_03260	COG0183	Belongs to the thiolase family
H5029_03270	COG2885	chlorophyll binding
H5029_03270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5029_03280	COG1690	Belongs to the RtcB family
H5029_03285	COG0833	amino acid
H5029_03295	COG2233	PERMEase
H5029_03300	COG1217	gtp-binding protein TYPA
H5029_03325	COG2094	Belongs to the DNA glycosylase MPG family
H5029_03330	COG4772	TonB-dependent receptor
H5029_03345	COG1902	pentaerythritol trinitrate reductase activity
H5029_03350	COG0679	Auxin Efflux Carrier
H5029_03360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5029_03365	COG0354	folic acid binding
H5029_03375	COG3189	MarR family transcriptional regulator
H5029_03380	COG2824	Alkylphosphonate utilization operon protein PhnA
H5029_03385	COG3422	double-strand break repair
H5029_03425	COG0840	transmembrane signaling receptor activity
H5029_03445	COG5510	response to toxic substance
H5029_03455	COG2832	Protein of unknown function (DUF454)
H5029_03460	COG1376	ErfK ybiS ycfS ynhG family protein
H5029_03500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5029_03510	COG1289	transmembrane transporter activity
H5029_03515	COG2814	Major facilitator Superfamily
H5029_03535	COG1115	amino acid carrier protein
H5029_03540	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5029_03545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5029_03550	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H5029_03590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5029_03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5029_03605	COG1077	Cell shape determining protein MreB Mrl
H5029_03610	COG1792	Involved in formation and maintenance of cell shape
H5029_03615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5029_03620	COG0424	maF-like protein
H5029_03625	COG1530	ribonuclease E activity
H5029_03635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_03645	COG0560	Phosphoserine phosphatase
H5029_03655	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_03680	COG2207	Transcriptional regulator
H5029_03700	COG1113	amino acid transport
H5029_03705	COG2828	Protein conserved in bacteria
H5029_03710	COG0142	geranyltranstransferase activity
H5029_03715	COG2315	Protein conserved in bacteria
H5029_03730	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5029_03750	COG2194	sulfuric ester hydrolase activity
H5029_03755	COG0745	RESPONSE REGULATOR receiver
H5029_03760	COG0642	Histidine kinase
H5029_03770	COG0004	ammonium transporteR
H5029_03775	COG0583	DNA-binding transcription factor activity
H5029_03795	COG0525	valine-tRNA ligase activity
H5029_03805	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_03815	COG0393	Putative heavy-metal-binding
H5029_03820	COG0393	Putative heavy-metal-binding
H5029_03825	COG1538	Outer membrane efflux protein
H5029_03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_03840	COG0671	phosphoesterase, PA-phosphatase related
H5029_03870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5029_03885	COG1648	precorrin-2 dehydrogenase activity
H5029_03885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5029_03890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5029_03895	COG1733	regulation of RNA biosynthetic process
H5029_03905	COG0531	amino acid
H5029_03920	COG0321	lipoyl(octanoyl) transferase activity
H5029_03925	COG2921	Belongs to the UPF0250 family
H5029_03970	COG2009	succinate dehydrogenase
H5029_03975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H5029_03980	COG1053	succinate dehydrogenase
H5029_03985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5029_04010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5029_04030	COG2354	Protein conserved in bacteria
H5029_04035	COG2321	neutral zinc metallopeptidase
H5029_04070	COG2843	Capsule synthesis protein
H5029_04085	COG0589	response to stress
H5029_04105	COG0505	Belongs to the CarA family
H5029_04130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5029_04135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5029_04185	COG0477	Major facilitator Superfamily
H5029_04190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5029_04205	COG1597	lipid kinase activity
H5029_04210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5029_04220	COG2826	transposase and inactivated derivatives, IS30 family
H5029_04250	COG0584	glycerophosphoryl diester phosphodiesterase
H5029_04270	COG0741	lytic transglycosylase activity
H5029_04290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5029_04305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_04330	COG0778	Nitroreductase
H5029_04345	COG1929	Belongs to the glycerate kinase type-1 family
H5029_04350	COG0243	molybdopterin cofactor binding
H5029_04355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5029_04360	COG3339	Conserved Protein
H5029_04370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5029_04385	COG1113	amino acid transport
H5029_04395	COG0019	diaminopimelate decarboxylase activity
H5029_04405	COG1280	lysine exporter protein (LysE YggA)
H5029_04410	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5029_04440	COG0463	Glycosyl transferase, family 2
H5029_04460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_04495	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5029_04500	COG1136	(ABC) transporter
H5029_04505	COG2333	competence protein COMEC
H5029_04505	COG0658	competence protein
H5029_04515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5029_04515	COG0616	signal peptide processing
H5029_04520	COG0596	Alpha beta hydrolase
H5029_04525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5029_04535	COG0628	permease
H5029_04570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5029_04590	COG0823	Involved in the tonB-independent uptake of proteins
H5029_04610	COG0824	Thioesterase
H5029_04615	COG1473	amidohydrolase
H5029_04635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5029_04635	COG0047	phosphoribosylformylglycinamidine synthase activity
H5029_04640	COG2814	Major facilitator Superfamily
H5029_04650	COG1024	Enoyl-CoA hydratase
H5029_04655	COG1056	cytidyltransferase-related domain
H5029_04655	COG1051	belongs to the nudix hydrolase family
H5029_04665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5029_04680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5029_04695	COG4625	pathogenesis
H5029_04705	COG0583	DNA-binding transcription factor activity
H5029_04710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H5029_04715	COG4208	sulfate ABC transporter
H5029_04720	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H5029_04730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H5029_04735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5029_04740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5029_04760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5029_04775	COG0681	Belongs to the peptidase S26 family
H5029_04790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5029_04800	COG1381	Involved in DNA repair and RecF pathway recombination
H5029_04805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5029_04815	COG4221	oxidoreductase activity
H5029_04845	COG0436	Aminotransferase
H5029_04865	COG0556	nucleotide-excision repair
H5029_04920	COG2070	2-Nitropropane dioxygenase
H5029_04950	COG1215	transferase activity, transferring glycosyl groups
H5029_04965	COG0415	Belongs to the DNA photolyase family
H5029_04975	COG1252	NADH dehydrogenase
H5029_04980	COG1686	Belongs to the peptidase S11 family
H5029_04995	COG1187	pseudouridine synthase activity
H5029_05020	COG0477	Major facilitator Superfamily
H5029_05025	COG0583	DNA-binding transcription factor activity
H5029_05030	COG1823	symporter activity
H5029_05040	COG0612	Peptidase, M16
H5029_05065	COG0352	thiamine-phosphate diphosphorylase activity
H5029_05100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_05115	COG1309	transcriptional regulator
H5029_05125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5029_05130	COG0076	glutamate decarboxylase activity
H5029_05140	COG1522	sequence-specific DNA binding
H5029_05145	COG3961	Belongs to the TPP enzyme family
H5029_05150	COG1113	amino acid transport
H5029_05155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5029_05160	COG0573	inorganic phosphate transmembrane transporter activity
H5029_05170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5029_05175	COG0616	signal peptide processing
H5029_05185	COG3328	transposase activity
H5029_05215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5029_05220	COG1686	Belongs to the peptidase S11 family
H5029_05245	COG0583	DNA-binding transcription factor activity
H5029_05250	COG1067	ATP-dependent peptidase activity
H5029_05295	COG1966	Carbon starvation protein
H5029_05300	COG2879	small protein
H5029_05330	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H5029_05330	COG2508	Transcriptional regulator
H5029_05350	COG1113	amino acid transport
H5029_05360	COG0583	DNA-binding transcription factor activity
H5029_05365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_05370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_05380	COG1012	belongs to the aldehyde dehydrogenase family
H5029_05385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_05390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5029_05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5029_05425	COG2814	Major facilitator Superfamily
H5029_05430	COG4948	Mandelate Racemase Muconate Lactonizing
H5029_05440	COG1309	transcriptional regulator
H5029_05460	COG1741	Belongs to the pirin family
H5029_05470	COG2964	Protein conserved in bacteria
H5029_05485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_05490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5029_05495	COG4605	iron ion homeostasis
H5029_05500	COG4604	ABC transporter, ATP-binding protein
H5029_05505	COG4607	ABC-type enterochelin transport system periplasmic component
H5029_05510	COG4774	siderophore transport
H5029_05520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_05525	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5029_05530	COG1535	isochorismatase
H5029_05530	COG3433	isochorismatase activity
H5029_05545	COG1132	(ABC) transporter
H5029_05550	COG1132	(ABC) transporter
H5029_05555	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H5029_05565	COG1169	isochorismate synthase
H5029_05580	COG3739	integral membrane protein
H5029_05605	COG0302	gtp cyclohydrolase
H5029_05615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5029_05645	COG0308	aminopeptidase N
H5029_05650	COG0512	Glutamine amidotransferase of anthranilate synthase
H5029_05665	COG0174	glutamine synthetase
H5029_05675	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5029_05710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5029_05715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5029_05720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5029_05740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5029_05745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5029_05750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5029_05765	COG1960	acyl-CoA dehydrogenase activity
H5029_05770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5029_05775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5029_05785	COG2223	nitrite transmembrane transporter activity
H5029_05795	COG0024	Methionine aminopeptidase
H5029_05800	COG0052	Belongs to the universal ribosomal protein uS2 family
H5029_05815	COG2207	Transcriptional regulator
H5029_05840	COG2951	lytic endotransglycosylase activity
H5029_05845	COG0772	Belongs to the SEDS family
H5029_05860	COG0842	Transport permease protein
H5029_05865	COG1131	(ABC) transporter
H5029_05910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_05925	COG4215	(ABC) transporter
H5029_05930	COG4160	amino acid transport
H5029_05935	COG4598	ABC transporter
H5029_05945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5029_05950	COG0826	peptidase U32
H5029_05955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_05970	COG1720	tRNA m6t6A37 methyltransferase activity
H5029_05980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5029_05995	COG0642	Histidine kinase
H5029_06005	COG0494	nUDIX hydrolase
H5029_06015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5029_06020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5029_06025	COG3139	Protein of unknown function (DUF1315)
H5029_06030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5029_06035	COG1301	dicarboxylic acid transport
H5029_06040	COG1960	acyl-CoA dehydrogenase activity
H5029_06045	COG2819	hydrolase of the alpha beta superfamily
H5029_06055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5029_06065	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5029_06070	COG1234	tRNA 3'-trailer cleavage
H5029_06100	COG2363	Small membrane protein
H5029_06120	COG0513	Belongs to the DEAD box helicase family
H5029_06130	COG0778	Nitroreductase
H5029_06160	COG1286	toxin biosynthetic process
H5029_06185	COG4783	chaperone-mediated protein folding
H5029_06190	COG1610	YqeY-like protein
H5029_06290	COG3111	PFAM Bacterial OB fold (BOF) protein
H5029_06315	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5029_06320	COG0786	glutamate:sodium symporter activity
H5029_06330	COG2186	Transcriptional regulator
H5029_06380	COG0477	Major facilitator Superfamily
H5029_06405	COG2985	domain, Protein
H5029_06415	COG2995	paraquat-inducible protein a
H5029_06420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5029_06420	COG3008	intermembrane lipid transfer
H5029_06430	COG1794	racemase activity, acting on amino acids and derivatives
H5029_06520	COG0482	sulfurtransferase activity
H5029_06535	COG0488	(ABC) transporter
H5029_06540	COG3173	Aminoglycoside phosphotransferase
H5029_06550	COG2433	Pfam Transposase IS66
H5029_06590	COG1301	dicarboxylic acid transport
H5029_06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5029_06605	COG2011	ABC-type metal ion transport system permease component
H5029_06610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5029_06615	COG1464	Belongs to the NlpA lipoprotein family
H5029_06620	COG0151	Belongs to the GarS family
H5029_06625	COG0138	bifunctional purine biosynthesis protein purh
H5029_06630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5029_06660	COG2308	Evidence 4 Homologs of previously reported genes of
H5029_06670	COG1305	Transglutaminase-like
H5029_06680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5029_06685	COG0305	Participates in initiation and elongation during chromosome replication
H5029_06710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5029_06720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5029_06725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5029_06750	COG1649	PFAM Uncharacterised BCR, COG1649
H5029_06750	COG0726	polysaccharide deacetylase
H5029_06755	COG1215	transferase activity, transferring glycosyl groups
H5029_06760	COG3658	cytochrome
H5029_06770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5029_06785	COG0583	DNA-binding transcription factor activity
H5029_06805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_06810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_06825	COG1960	acyl-CoA dehydrogenase activity
H5029_06830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5029_06835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_06860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H5029_06865	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5029_06875	COG2205	protein histidine kinase activity
H5029_06880	COG0745	RESPONSE REGULATOR receiver
H5029_06885	COG0174	glutamine synthetase
H5029_06905	COG0729	surface antigen
H5029_06930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5029_06935	COG2814	Major facilitator Superfamily
H5029_06950	COG0583	DNA-binding transcription factor activity
H5029_06965	COG1187	pseudouridine synthase activity
H5029_06985	COG0802	atpase or kinase
H5029_06990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5029_07000	COG1923	regulation of RNA biosynthetic process
H5029_07005	COG0697	spore germination
H5029_07020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5029_07030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5029_07035	COG0519	Catalyzes the synthesis of GMP from XMP
H5029_07035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5029_07040	COG4302	ethanolamine ammonia-lyase activity
H5029_07045	COG4303	Ethanolamine ammonia lyase large subunit
H5029_07050	COG0531	amino acid
H5029_07070	COG1454	alcohol dehydrogenase
H5029_07075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5029_07085	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H5029_07105	COG0308	aminopeptidase N
H5029_07135	COG1605	Chorismate mutase
H5029_07150	COG1309	transcriptional regulator
H5029_07160	COG0668	transmembrane transport
H5029_07200	COG4773	Receptor
H5029_07220	COG0488	(ABC) transporter
H5029_07225	COG0589	response to stress
H5029_07250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H5029_07260	COG3135	benzoate transporter
H5029_07265	COG1522	sequence-specific DNA binding
H5029_07275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5029_07280	COG0583	DNA-binding transcription factor activity
H5029_07290	COG0183	Belongs to the thiolase family
H5029_07300	COG2030	dehydratase
H5029_07305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5029_07320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5029_07335	COG0824	Thioesterase
H5029_07340	COG1454	alcohol dehydrogenase
H5029_07350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5029_07370	COG0069	glutamate synthase activity
H5029_07390	COG2814	Major facilitator Superfamily
H5029_07405	COG0511	ligase activity, forming carbon-carbon bonds
H5029_07425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_07425	COG1116	anion transmembrane transporter activity
H5029_07430	COG0745	RESPONSE REGULATOR receiver
H5029_07440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_07440	COG2146	nitrite reductase [NAD(P)H] activity
H5029_07445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_07450	COG0243	molybdopterin cofactor binding
H5029_07460	COG0243	molybdopterin cofactor binding
H5029_07465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5029_07480	COG0315	cyclic pyranopterin monophosphate synthase activity
H5029_07480	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5029_07485	COG0303	'Molybdopterin
H5029_07495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_07500	COG0697	spore germination
H5029_07520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H5029_07525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5029_07580	COG2204	response regulator
H5029_07585	COG3852	Histidine kinase
H5029_07605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5029_07610	COG0575	Belongs to the CDS family
H5029_07645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5029_07660	COG2137	regulation of response to DNA damage stimulus
H5029_07670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5029_07675	COG1011	Hydrolase
H5029_07700	COG1522	sequence-specific DNA binding
H5029_07710	COG1113	amino acid transport
H5029_07725	COG0659	secondary active sulfate transmembrane transporter activity
H5029_07730	COG2135	peptidase activity
H5029_07745	COG5001	Diguanylate cyclase
H5029_07745	COG3300	MHYT domain
H5029_07765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5029_07765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5029_07765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H5029_07770	COG1105	Belongs to the carbohydrate kinase PfkB family
H5029_07775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5029_07775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5029_07805	COG0024	Methionine aminopeptidase
H5029_07810	COG0583	DNA-binding transcription factor activity
H5029_07820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5029_07825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5029_07830	COG0516	GMP reductase activity
H5029_07830	COG0517	IMP dehydrogenase activity
H5029_07855	COG0552	protein localization to endoplasmic reticulum
H5029_07865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5029_07880	COG4890	Cyd operon protein YbgT
H5029_07885	COG1294	oxidase, subunit
H5029_07900	COG1585	Membrane protein implicated in regulation of membrane protease activity
H5029_07910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5029_07915	COG4774	siderophore transport
H5029_07930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5029_07935	COG0569	domain protein
H5029_07940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5029_07970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5029_07975	COG0542	response to heat
H5029_08000	COG1902	pentaerythritol trinitrate reductase activity
H5029_08000	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_08045	COG2323	membrane
H5029_08050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5029_08060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5029_08065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_08070	COG0183	Belongs to the thiolase family
H5029_08075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5029_08080	COG0596	Alpha beta hydrolase
H5029_08085	COG2271	Major facilitator Superfamily
H5029_08090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5029_08095	COG3485	protocatechuate 3,4-dioxygenase
H5029_08100	COG3485	protocatechuate 3,4-dioxygenase
H5029_08105	COG0710	3-dehydroquinate dehydratase activity
H5029_08110	COG3420	alginic acid biosynthetic process
H5029_08115	COG3659	wide pore channel activity
H5029_08120	COG4993	Dehydrogenase
H5029_08130	COG2391	methyltransferase activity
H5029_08145	COG1414	Transcriptional regulator
H5029_08150	COG0583	DNA-binding transcription factor activity
H5029_08155	COG1960	acyl-CoA dehydrogenase activity
H5029_08180	COG2814	Major facilitator Superfamily
H5029_08190	COG0154	amidase activity
H5029_08210	COG4638	Rieske (2fe-2S)
H5029_08220	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_08230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_08240	COG3733	amine oxidase
H5029_08250	COG1012	belongs to the aldehyde dehydrogenase family
H5029_08260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5029_08265	COG0183	Belongs to the thiolase family
H5029_08270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_08275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5029_08285	COG4829	muconolactone delta-isomerase
H5029_08290	COG4948	Mandelate Racemase Muconate Lactonizing
H5029_08295	COG0583	DNA-binding transcription factor activity
H5029_08305	COG2186	Transcriptional regulator
H5029_08325	COG1012	belongs to the aldehyde dehydrogenase family
H5029_08345	COG1960	acyl-CoA dehydrogenase activity
H5029_08350	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_08355	COG3829	transcription factor binding
H5029_08365	COG3162	membrane
H5029_08380	COG1012	belongs to the aldehyde dehydrogenase family
H5029_08395	COG0753	catalase activity
H5029_08415	COG1846	Transcriptional regulator
H5029_08420	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_08420	COG1902	pentaerythritol trinitrate reductase activity
H5029_08430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5029_08460	COG1309	transcriptional regulator
H5029_08470	COG1335	isochorismatase
H5029_08475	COG0583	DNA-binding transcription factor activity
H5029_08485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5029_08485	COG0475	glutathione-regulated potassium exporter activity
H5029_08495	COG1473	amidohydrolase
H5029_08505	COG2831	hemolysin activation secretion protein
H5029_08510	COG3210	domain, Protein
H5029_08540	COG2188	Transcriptional regulator
H5029_08555	COG0583	DNA-binding transcription factor activity
H5029_08585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5029_08605	COG1566	PFAM secretion protein HlyD family protein
H5029_08620	COG1012	belongs to the aldehyde dehydrogenase family
H5029_08625	COG0129	dihydroxy-acid dehydratase activity
H5029_08635	COG0583	DNA-binding transcription factor activity
H5029_08640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5029_08650	COG2084	Dehydrogenase
H5029_08655	COG2207	Transcriptional regulator
H5029_08670	COG1064	alcohol dehydrogenase
H5029_08680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5029_08685	COG1120	ATPase activity
H5029_08705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5029_08820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5029_08870	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_08885	COG2207	Transcriptional regulator
H5029_08895	COG2205	protein histidine kinase activity
H5029_08900	COG0745	RESPONSE REGULATOR receiver
H5029_08905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_08910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5029_08915	COG1538	Outer membrane efflux protein
H5029_08925	COG2072	flavoprotein involved in K transport
H5029_08945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5029_08965	COG3539	Fimbrial protein
H5029_08995	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5029_09005	COG0753	catalase activity
H5029_09020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5029_09085	COG3433	isochorismatase activity
H5029_09085	COG1535	isochorismatase
H5029_09090	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_09095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5029_09100	COG4149	molybdate abc transporter
H5029_09105	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5029_09115	COG4638	Rieske (2fe-2S)
H5029_09120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H5029_09125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_09125	COG0543	2 iron, 2 sulfur cluster binding
H5029_09150	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_09165	COG2207	Transcriptional regulator
H5029_09175	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_09180	COG2610	gluconate transmembrane transporter activity
H5029_09190	COG0583	DNA-binding transcription factor activity
H5029_09205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_09210	COG2031	fatty acid transporter
H5029_09215	COG0183	Belongs to the thiolase family
H5029_09220	COG0583	DNA-binding transcription factor activity
H5029_09225	COG0583	DNA-binding transcription factor activity
H5029_09240	COG1027	Aspartate ammonia-lyase
H5029_09250	COG0477	Major facilitator Superfamily
H5029_09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_09275	COG4521	taurine ABC transporter
H5029_09290	COG2188	Transcriptional regulator
H5029_09300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5029_09305	COG1733	regulation of RNA biosynthetic process
H5029_09310	COG3708	Transcriptional regulator
H5029_09310	COG2207	Transcriptional regulator
H5029_09325	COG0730	response to heat
H5029_09335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5029_09335	COG3453	Protein conserved in bacteria
H5029_09345	COG3781	membrane
H5029_09350	COG1063	alcohol dehydrogenase
H5029_09360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5029_09365	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5029_09370	COG0022	dehydrogenase e1 component
H5029_09375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5029_09380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5029_09395	COG3706	GGDEF domain
H5029_09410	COG0133	tryptophan synthase activity
H5029_09420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5029_09455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5029_09480	COG2226	methyltransferase
H5029_09535	COG0842	Transport permease protein
H5029_09540	COG0842	Transport permease protein
H5029_09545	COG1131	(ABC) transporter
H5029_09560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5029_09565	COG4773	Receptor
H5029_09585	COG0730	response to heat
H5029_09590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5029_09610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5029_09625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5029_09665	COG4264	IucA IucC family
H5029_09670	COG4264	IucA IucC family
H5029_09690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5029_09705	COG1960	acyl-CoA dehydrogenase activity
H5029_09710	COG1960	acyl-CoA dehydrogenase activity
H5029_09715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5029_09720	COG2207	Transcriptional regulator
H5029_09725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5029_09730	COG0776	regulation of translation
H5029_09755	COG0822	iron-sulfur transferase activity
H5029_09760	COG0316	Belongs to the HesB IscA family
H5029_09790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5029_09810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5029_09815	COG0702	epimerase
H5029_09850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5029_09860	COG0339	signal peptide processing
H5029_09910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5029_09915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5029_09945	COG0776	regulation of translation
H5029_10010	COG0084	hydrolase, TatD family'
H5029_10030	COG1663	tetraacyldisaccharide 4'-kinase activity
H5029_10035	COG1132	(ABC) transporter
H5029_10045	COG0811	peptide transport
H5029_10050	COG1475	DNA binding
H5029_10055	COG1192	Involved in chromosome partitioning
H5029_10065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5029_10080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5029_10085	COG0191	fructose-bisphosphate aldolase activity
H5029_10105	COG0424	maF-like protein
H5029_10110	COG2850	peptidyl-arginine hydroxylation
H5029_10120	COG0640	Transcriptional regulator
H5029_10135	COG3619	membrane
H5029_10140	COG3122	Protein conserved in bacteria
H5029_10145	COG1132	(ABC) transporter
H5029_10165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5029_10170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5029_10180	COG0506	proline dehydrogenase activity
H5029_10180	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5029_10180	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5029_10185	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H5029_10200	COG3698	Phosphodiester glycosidase
H5029_10210	COG2353	YceI-like domain
H5029_10220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5029_10265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5029_10265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5029_10290	COG3539	Fimbrial protein
H5029_10295	COG3121	Chaperone
H5029_10320	COG0697	spore germination
H5029_10330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5029_10340	COG0583	DNA-binding transcription factor activity
H5029_10360	COG1309	transcriptional regulator
H5029_10375	COG1522	sequence-specific DNA binding
H5029_10385	COG1126	abc transporter atp-binding protein
H5029_10390	COG0765	amino acid transport
H5029_10395	COG0765	amino acid transport
H5029_10425	COG1464	Belongs to the NlpA lipoprotein family
H5029_10435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5029_10440	COG2011	ABC-type metal ion transport system permease component
H5029_10445	COG0012	GTP binding
H5029_10470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5029_10510	COG0386	Belongs to the glutathione peroxidase family
H5029_10520	COG0436	Aminotransferase
H5029_10560	COG3634	alkyl hydroperoxide reductase activity
H5029_10575	COG0583	DNA-binding transcription factor activity
H5029_10580	COG0798	PFAM Bile acid sodium symporter
H5029_10585	COG0640	Transcriptional regulator
H5029_10600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5029_10610	COG0583	DNA-binding transcription factor activity
H5029_10620	COG1953	Uracil, thiamine, allantoin
H5029_10630	COG2175	clavaminate synthase activity
H5029_10635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_10640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5029_10645	COG4521	taurine ABC transporter
H5029_10660	COG0477	Major facilitator Superfamily
H5029_10680	COG1271	oxidase subunit
H5029_10685	COG1294	oxidase, subunit
H5029_10695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_10715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5029_10735	COG3052	prosthetic group binding
H5029_10740	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H5029_10750	COG2814	Major facilitator Superfamily
H5029_10770	COG1346	cytolysis
H5029_10780	COG0583	DNA-binding transcription factor activity
H5029_10785	COG0625	glutathione transferase activity
H5029_10790	COG0625	glutathione transferase activity
H5029_10795	COG0583	DNA-binding transcription factor activity
H5029_10810	COG1045	serine acetyltransferase
H5029_10815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5029_10820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5029_10830	COG1280	lysine exporter protein (LysE YggA)
H5029_10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5029_10850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5029_10855	COG1126	abc transporter atp-binding protein
H5029_10860	COG0765	amino acid transport
H5029_10865	COG0765	amino acid transport
H5029_10885	COG2205	protein histidine kinase activity
H5029_10885	COG0784	Response regulator, receiver
H5029_10905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5029_10925	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_10975	COG0583	DNA-binding transcription factor activity
H5029_10995	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_11000	COG1309	transcriptional regulator
H5029_11005	COG1960	acyl-CoA dehydrogenase activity
H5029_11010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5029_11015	COG1024	Enoyl-CoA hydratase
H5029_11020	COG4770	biotin carboxylase activity
H5029_11030	COG0583	DNA-binding transcription factor activity
H5029_11045	COG1960	acyl-CoA dehydrogenase activity
H5029_11055	COG2814	Major facilitator Superfamily
H5029_11065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_11070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5029_11075	COG2814	Major facilitator Superfamily
H5029_11080	COG1960	acyl-CoA dehydrogenase activity
H5029_11085	COG1024	Enoyl-CoA hydratase
H5029_11090	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_11095	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5029_11100	COG0183	Belongs to the thiolase family
H5029_11110	COG2814	Major facilitator Superfamily
H5029_11120	COG1024	Enoyl-CoA hydratase
H5029_11135	COG1960	acyl-CoA dehydrogenase activity
H5029_11140	COG2814	Major facilitator Superfamily
H5029_11145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5029_11150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5029_11165	COG3842	ATPase activity
H5029_11170	COG1840	ABC-type Fe3 transport system, periplasmic component
H5029_11180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_11185	COG1414	Transcriptional regulator
H5029_11195	COG0583	DNA-binding transcription factor activity
H5029_11200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5029_11205	COG1012	belongs to the aldehyde dehydrogenase family
H5029_11215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5029_11225	COG1012	belongs to the aldehyde dehydrogenase family
H5029_11230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5029_11235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_11240	COG2267	carboxylic ester hydrolase activity
H5029_11260	COG3038	cytochrome b561
H5029_11265	COG0753	catalase activity
H5029_11300	COG2050	protein possibly involved in aromatic compounds catabolism
H5029_11310	COG3327	negative regulation of DNA-templated transcription, initiation
H5029_11315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H5029_11320	COG0183	Belongs to the thiolase family
H5029_11325	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5029_11330	COG1024	Enoyl-CoA hydratase
H5029_11335	COG1024	Enoyl-CoA hydratase
H5029_11340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_11345	COG2151	metal-sulfur cluster biosynthetic enzyme
H5029_11350	COG3396	Phenylacetate-CoA oxygenase
H5029_11355	COG3460	Phenylacetate-CoA oxygenase
H5029_11360	COG3396	Phenylacetate-CoA oxygenase
H5029_11365	COG1012	belongs to the aldehyde dehydrogenase family
H5029_11365	COG2030	dehydratase
H5029_11370	COG1760	l-serine dehydratase
H5029_11375	COG0531	amino acid
H5029_11380	COG1012	belongs to the aldehyde dehydrogenase family
H5029_11395	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5029_11425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_11435	COG0789	Transcriptional regulator
H5029_11450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5029_11465	COG2807	transmembrane transport
H5029_11470	COG0590	tRNA wobble adenosine to inosine editing
H5029_11585	COG1116	anion transmembrane transporter activity
H5029_11590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5029_11600	COG0864	Transcriptional regulator
H5029_11620	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_11625	COG0439	Biotin carboxylase
H5029_11640	COG1063	alcohol dehydrogenase
H5029_11650	COG1309	transcriptional regulator
H5029_11695	COG1914	H( )-stimulated, divalent metal cation uptake system
H5029_11700	COG0583	DNA-binding transcription factor activity
H5029_11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5029_11780	COG1560	Kdo2-lipid A biosynthetic process
H5029_11795	COG5006	permease, DMT superfamily
H5029_11800	COG1522	sequence-specific DNA binding
H5029_11815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5029_11825	COG4122	O-methyltransferase activity
H5029_11855	COG1538	Outer membrane efflux protein
H5029_11860	COG1137	ATPase activity
H5029_11865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5029_11875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H5029_11880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5029_11880	COG0517	IMP dehydrogenase activity
H5029_11915	COG2814	Major facilitator Superfamily
H5029_11950	COG1278	Cold shock
H5029_11955	COG1280	lysine exporter protein (LysE YggA)
H5029_11985	COG1570	exodeoxyribonuclease VII activity
H5029_12035	COG0583	DNA-binding transcription factor activity
H5029_12040	COG4638	Rieske (2fe-2S)
H5029_12045	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H5029_12050	COG0543	2 iron, 2 sulfur cluster binding
H5029_12050	COG0633	Ferredoxin
H5029_12055	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_12060	COG3135	benzoate transporter
H5029_12065	COG2814	Major facilitator Superfamily
H5029_12080	COG1643	Atp-dependent helicase
H5029_12085	COG0450	alkyl hydroperoxide reductase
H5029_12095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5029_12105	COG3634	alkyl hydroperoxide reductase activity
H5029_12125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5029_12130	COG0625	glutathione transferase activity
H5029_12140	COG2885	chlorophyll binding
H5029_12175	COG0542	response to heat
H5029_12190	COG1765	OsmC-like protein
H5029_12205	COG0667	Aldo Keto reductase
H5029_12220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5029_12230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5029_12240	COG0527	aspartate kinase activity
H5029_12250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5029_12260	COG3038	cytochrome b561
H5029_12265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5029_12270	COG2252	PERMEase
H5029_12280	COG2072	flavoprotein involved in K transport
H5029_12295	COG1741	Belongs to the pirin family
H5029_12300	COG1309	transcriptional regulator
H5029_12325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5029_12365	COG1902	pentaerythritol trinitrate reductase activity
H5029_12365	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_12375	COG3706	GGDEF domain
H5029_12375	COG5001	Diguanylate cyclase
H5029_12375	COG4251	negative regulation of phosphorylation
H5029_12375	COG2203	Gaf domain
H5029_12385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5029_12405	COG4172	Belongs to the ABC transporter superfamily
H5029_12410	COG4239	(ABC) transporter, permease
H5029_12415	COG4174	ABC transporter (Permease)
H5029_12425	COG0741	lytic transglycosylase activity
H5029_12425	COG1388	LysM domain
H5029_12425	COG1388	LysM domain
H5029_12425	COG0741	lytic transglycosylase activity
H5029_12430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5029_12470	COG0583	DNA-binding transcription factor activity
H5029_12475	COG1279	arginine transmembrane transporter activity
H5029_12495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_12500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_12505	COG0006	proline dipeptidase activity
H5029_12540	COG2194	sulfuric ester hydrolase activity
H5029_12585	COG0739	heme binding
H5029_12910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5029_12935	COG3384	dioxygenase
H5029_12945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5029_12950	COG2878	Part of a membrane complex involved in electron transport
H5029_12955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5029_12980	COG0768	penicillin binding
H5029_12985	COG0742	ribosomal rna small subunit methyltransferase
H5029_13000	COG0830	nickel cation binding
H5029_13010	COG0804	urea catabolic process
H5029_13050	COG1253	flavin adenine dinucleotide binding
H5029_13055	COG2851	Citrate transporter
H5029_13110	COG1773	rubredoxin
H5029_13115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_13125	COG0583	DNA-binding transcription factor activity
H5029_13150	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5029_13155	COG4181	ATPase activity
H5029_13200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5029_13220	COG0306	phosphate transporter
H5029_13230	COG3958	Transketolase
H5029_13235	COG3959	Transketolase, thiamine diphosphate binding domain
H5029_13240	COG2271	Major facilitator Superfamily
H5029_13245	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_13250	COG0583	DNA-binding transcription factor activity
H5029_13265	COG2223	nitrite transmembrane transporter activity
H5029_13270	COG2207	Transcriptional regulator
H5029_13275	COG2066	Belongs to the glutaminase family
H5029_13280	COG0242	peptide deformylase activity
H5029_13285	COG0477	Major facilitator Superfamily
H5029_13295	COG0028	Belongs to the TPP enzyme family
H5029_13310	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_13315	COG2267	carboxylic ester hydrolase activity
H5029_13325	COG2271	Major facilitator Superfamily
H5029_13330	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_13340	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_13360	COG1414	Transcriptional regulator
H5029_13375	COG1024	Enoyl-CoA hydratase
H5029_13385	COG1215	transferase activity, transferring glycosyl groups
H5029_13390	COG1649	PFAM Uncharacterised BCR, COG1649
H5029_13390	COG0726	polysaccharide deacetylase
H5029_13400	COG4681	YaeQ
H5029_13410	COG0523	cobalamin synthesis protein
H5029_13420	COG1607	acyl-coa hydrolase
H5029_13430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_13435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_13440	COG1309	transcriptional regulator
H5029_13465	COG2040	homocysteine
H5029_13470	COG0531	amino acid
H5029_13525	COG1595	DNA-templated transcription, initiation
H5029_13535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_13540	COG0477	Major facilitator Superfamily
H5029_13560	COG0084	hydrolase, TatD family'
H5029_13595	COG0629	single-stranded DNA binding
H5029_13650	COG0582	viral genome integration into host DNA
H5029_13665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5029_13790	COG3566	protein conserved in bacteria
H5029_13805	COG3567	Phage-associated protein, HI1409 family
H5029_13810	COG5410	chromosome segregation
H5029_13890	COG4197	protein conserved in bacteria, prophage-related
H5029_13895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5029_13960	COG0405	Gamma-glutamyltransferase
H5029_13965	COG2814	Major facilitator Superfamily
H5029_13975	COG2050	protein possibly involved in aromatic compounds catabolism
H5029_13990	COG1090	epimerase
H5029_14010	COG0420	3'-5' exonuclease activity
H5029_14035	COG0735	belongs to the Fur family
H5029_14040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5029_14060	COG0121	glutamine amidotransferase
H5029_14075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5029_14085	COG0210	DNA helicase
H5029_14090	COG2885	chlorophyll binding
H5029_14095	COG0204	Acyl-transferase
H5029_14110	COG2894	cell division
H5029_14130	COG1280	lysine exporter protein (LysE YggA)
H5029_14135	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5029_14135	COG1674	ftsk spoiiie
H5029_14140	COG0492	ferredoxin-NADP+ reductase activity
H5029_14145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5029_14155	COG0456	acetyltransferase
H5029_14200	COG1981	membrane
H5029_14215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5029_14215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5029_14235	COG1012	belongs to the aldehyde dehydrogenase family
H5029_14245	COG0657	acetylesterase activity
H5029_14255	COG0473	3-isopropylmalate dehydrogenase activity
H5029_14260	COG0583	DNA-binding transcription factor activity
H5029_14280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5029_14305	COG0564	pseudouridine synthase activity
H5029_14315	COG0358	DNA primase activity
H5029_14330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5029_14360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5029_14390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5029_14400	COG0351	phosphomethylpyrimidine kinase
H5029_14400	COG0352	thiamine-phosphate diphosphorylase activity
H5029_14400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5029_14405	COG1652	LysM domain
H5029_14430	COG1399	metal-binding, possibly nucleic acid-binding protein
H5029_14435	COG3101	peptidyl-lysine hydroxylation
H5029_14440	COG0009	L-threonylcarbamoyladenylate synthase
H5029_14445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H5029_14450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5029_14465	COG4106	trans-aconitate 2-methyltransferase activity
H5029_14480	COG2226	methyltransferase
H5029_14480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5029_14480	COG0596	Alpha beta hydrolase
H5029_14485	COG1877	trehalose-phosphatase activity
H5029_14490	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H5029_14495	COG2223	nitrite transmembrane transporter activity
H5029_14515	COG1196	nuclear chromosome segregation
H5029_14525	COG0730	response to heat
H5029_14540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5029_14550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5029_14600	COG0489	protein tyrosine kinase activity
H5029_14610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5029_14610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5029_14640	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5029_14645	COG2081	HI0933 family
H5029_14655	COG0668	transmembrane transport
H5029_14675	COG0583	DNA-binding transcription factor activity
H5029_14695	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5029_14700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5029_14730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H5029_14770	COG0745	RESPONSE REGULATOR receiver
H5029_14790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5029_14800	COG2205	protein histidine kinase activity
H5029_14870	COG4993	Dehydrogenase
H5029_14895	COG0384	phenazine biosynthesis protein PhzF
H5029_14915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_14930	COG0583	DNA-binding transcription factor activity
H5029_14960	COG0583	DNA-binding transcription factor activity
H5029_14975	COG0583	DNA-binding transcription factor activity
H5029_14980	COG1053	succinate dehydrogenase
H5029_14990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5029_14995	COG2814	Major facilitator Superfamily
H5029_15000	COG1960	acyl-CoA dehydrogenase activity
H5029_15005	COG0583	DNA-binding transcription factor activity
H5029_15010	COG1063	alcohol dehydrogenase
H5029_15040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5029_15045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5029_15050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5029_15065	COG3667	copper resistance
H5029_15070	COG2132	Multicopper oxidase
H5029_15080	COG0561	phosphatase activity
H5029_15085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5029_15110	COG1214	PFAM Peptidase M22, glycoprotease
H5029_15165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5029_15175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5029_15180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5029_15185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5029_15245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5029_15255	COG1846	Transcriptional regulator
H5029_15260	COG1764	response to oxidative stress
H5029_15310	COG0037	tRNA processing
H5029_15320	COG0248	Ppx GppA phosphatase
H5029_15350	COG0072	phenylalanine-tRNA ligase activity
H5029_15390	COG1238	metal cluster binding
H5029_15395	COG0625	glutathione transferase activity
H5029_15410	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_15415	COG3028	Belongs to the UPF0307 family
H5029_15420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5029_15440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5029_15445	COG0617	tRNA 3'-terminal CCA addition
H5029_15450	COG1555	photosystem II stabilization
H5029_15455	COG3956	TIGRFAM MazG family protein
H5029_15465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5029_15485	COG5002	protein histidine kinase activity
H5029_15485	COG2205	protein histidine kinase activity
H5029_15485	COG0784	Response regulator, receiver
H5029_15490	COG1024	Enoyl-CoA hydratase
H5029_15495	COG2084	Dehydrogenase
H5029_15500	COG3622	Belongs to the hyi family
H5029_15530	COG0697	spore germination
H5029_15540	COG2814	Major facilitator Superfamily
H5029_15545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5029_15555	COG0583	DNA-binding transcription factor activity
H5029_15565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5029_15575	COG0084	hydrolase, TatD family'
H5029_15590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5029_15620	COG0440	acetolactate synthase activity
H5029_15625	COG0028	Belongs to the TPP enzyme family
H5029_15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_15660	COG1136	(ABC) transporter
H5029_15660	COG0577	efflux transmembrane transporter activity
H5029_15665	COG1538	Outer membrane efflux protein
H5029_15680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5029_15685	COG1162	GTPase activity
H5029_15695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5029_15735	COG1426	Protein conserved in bacteria
H5029_15770	COG0793	Belongs to the peptidase S41A family
H5029_15795	COG1012	belongs to the aldehyde dehydrogenase family
H5029_15800	COG3265	gluconokinase activity
H5029_15810	COG0800	Aldolase
H5029_15820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5029_15825	COG0857	belongs to the CobB CobQ family
H5029_15825	COG0280	phosphate acetyltransferase
H5029_15830	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H5029_15830	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H5029_15850	COG0740	serine-type endopeptidase activity
H5029_15860	COG4774	siderophore transport
H5029_15870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5029_15880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5029_15880	COG2813	Specifically methylates the guanine in position
H5029_15980	COG0788	formyltetrahydrofolate deformylase activity
H5029_16005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5029_16005	COG4651	solute:proton antiporter activity
H5029_16025	COG0724	RNA recognition motif
H5029_16030	COG0210	DNA helicase
H5029_16055	COG1733	regulation of RNA biosynthetic process
H5029_16065	COG2900	Belongs to the SlyX family
H5029_16070	COG0488	(ABC) transporter
H5029_16075	COG1280	lysine exporter protein (LysE YggA)
H5029_16080	COG1560	Kdo2-lipid A biosynthetic process
H5029_16090	COG1301	dicarboxylic acid transport
H5029_16115	COG0252	asparaginase activity
H5029_16145	COG0473	3-isopropylmalate dehydrogenase activity
H5029_16200	COG0583	DNA-binding transcription factor activity
H5029_16210	COG0625	glutathione transferase activity
H5029_16215	COG2378	regulation of single-species biofilm formation
H5029_16220	COG0546	phosphoglycolate phosphatase activity
H5029_16230	COG1530	ribonuclease E activity
H5029_16235	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_16250	COG0583	DNA-binding transcription factor activity
H5029_16255	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_16260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5029_16270	COG0534	Mate efflux family protein
H5029_16285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5029_16315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5029_16315	COG0493	'glutamate synthase
H5029_16325	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5029_16330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5029_16345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5029_16355	COG0644	oxidoreductase
H5029_16355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H5029_16365	COG0425	Belongs to the sulfur carrier protein TusA family
H5029_16370	COG4535	Mg2 and Co2 transporter CorC
H5029_16380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5029_16400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5029_16405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5029_16405	COG0475	glutathione-regulated potassium exporter activity
H5029_16420	COG0484	heat shock protein binding
H5029_16425	COG0789	Transcriptional regulator
H5029_16430	COG0598	Magnesium transport protein CorA
H5029_16450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5029_16455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5029_16460	COG1074	ATP-dependent DNA helicase activity
H5029_16465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H5029_16485	COG2226	methyltransferase
H5029_16495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5029_16510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5029_16525	COG2111	Na H antiporter
H5029_16525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5029_16530	COG1006	Multisubunit Na H antiporter MnhC subunit
H5029_16535	COG0651	ATP synthesis coupled electron transport
H5029_16540	COG1863	multisubunit Na H antiporter MnhE subunit
H5029_16545	COG2212	antiporter activity
H5029_16550	COG1320	monovalent cation:proton antiporter activity
H5029_16565	COG0195	Participates in both transcription termination and antitermination
H5029_16615	COG0237	dephospho-CoA kinase activity
H5029_16625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5029_16640	COG0497	DNA recombination
H5029_16650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5029_16680	COG2169	Transcriptional regulator
H5029_16680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5029_16685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5029_16740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H5029_16755	COG0326	Molecular chaperone. Has ATPase activity
H5029_16770	COG2056	Na+-H+ antiporter family
H5029_16870	COG0546	phosphoglycolate phosphatase activity
H5029_16875	COG1716	ATPase activity
H5029_16920	COG0181	hydroxymethylbilane synthase activity
H5029_16930	COG3275	phosphorelay sensor kinase activity
H5029_16955	COG0697	spore germination
H5029_16980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5029_16985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5029_16990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5029_16995	COG0772	Belongs to the SEDS family
H5029_17020	COG4974	Belongs to the 'phage' integrase family
H5029_17025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5029_17035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5029_17045	COG2197	response regulator
H5029_17060	COG0793	Belongs to the peptidase S41A family
H5029_17065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H5029_17070	COG0795	lipopolysaccharide-transporting ATPase activity
H5029_17110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5029_17110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5029_17120	COG0004	ammonium transporteR
H5029_17125	COG0347	Belongs to the P(II) protein family
H5029_17135	COG0606	chelatase, subunit chli
H5029_17145	COG0659	secondary active sulfate transmembrane transporter activity
H5029_17150	COG0589	response to stress
H5029_17190	COG0606	chelatase, subunit chli
H5029_17195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_17205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_17220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5029_17235	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_17245	COG0477	Major facilitator Superfamily
H5029_17250	COG2860	membrane
H5029_17260	COG1253	flavin adenine dinucleotide binding
H5029_17270	COG0477	Major facilitator Superfamily
H5029_17280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5029_17315	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5029_17325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5029_17360	COG1309	transcriptional regulator
H5029_17395	COG0758	DNA mediated transformation
H5029_17405	COG0697	spore germination
H5029_17410	COG1309	transcriptional regulator
H5029_17425	COG0386	Belongs to the glutathione peroxidase family
H5029_17490	COG1121	(ABC) transporter
H5029_17495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5029_17500	COG1280	lysine exporter protein (LysE YggA)
H5029_17505	COG2837	iron assimilation
H5029_17510	COG0281	malic enzyme
H5029_17555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5029_17555	COG0519	Catalyzes the synthesis of GMP from XMP
H5029_17560	COG4399	Belongs to the UPF0754 family
H5029_17565	COG2259	Doxx family
H5029_17570	COG0586	Pfam SNARE associated Golgi protein
H5029_17585	COG1192	Involved in chromosome partitioning
H5029_17595	COG0271	Belongs to the BolA IbaG family
H5029_17635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H5029_17635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5029_17635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5029_17635	COG3321	synthase
H5029_17640	COG1960	acyl-CoA dehydrogenase activity
H5029_17650	COG2197	response regulator
H5029_17660	COG3916	Acyl-homoserine-lactone synthase
H5029_17665	COG0477	Major facilitator Superfamily
H5029_17670	COG1024	Enoyl-CoA hydratase
H5029_17675	COG1024	Enoyl-CoA hydratase
H5029_17680	COG1960	acyl-CoA dehydrogenase activity
H5029_17685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5029_17705	COG1113	amino acid transport
H5029_17710	COG1113	amino acid transport
H5029_17715	COG0251	oxidation-reduction process
H5029_17755	COG0564	pseudouridine synthase activity
H5029_17800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5029_17815	COG1802	Transcriptional regulator
H5029_17825	COG1448	Aminotransferase
H5029_17830	COG0277	FAD linked oxidase domain protein
H5029_17840	COG2186	Transcriptional regulator
H5029_17850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5029_17860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5029_17875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5029_17880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5029_17885	COG1216	Glycosyl transferase, family 2
H5029_17900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5029_17900	COG1215	transferase activity, transferring glycosyl groups
H5029_17905	COG1442	glycosyl transferase family 8
H5029_17905	COG1216	Glycosyl transferase, family 2
H5029_17915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H5029_17920	COG1596	polysaccharide export
H5029_17945	COG0728	peptidoglycan biosynthetic process
H5029_17950	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5029_18005	COG0546	phosphoglycolate phosphatase activity
H5029_18010	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_18030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_18035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_18040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5029_18045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_18050	COG1116	anion transmembrane transporter activity
H5029_18055	COG1309	transcriptional regulator
H5029_18060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5029_18070	COG0196	riboflavin kinase activity
H5029_18075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5029_18085	COG1047	Peptidyl-prolyl cis-trans
H5029_18125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5029_18130	COG0657	acetylesterase activity
H5029_18180	COG2951	lytic endotransglycosylase activity
H5029_18185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5029_18200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5029_18210	COG0671	phosphoesterase, PA-phosphatase related
H5029_18215	COG0861	Integral membrane protein TerC family
H5029_18225	COG0754	glutathionylspermidine amidase activity
H5029_18235	COG0402	S-adenosylhomocysteine deaminase activity
H5029_18250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5029_18255	COG1230	cation diffusion facilitator family transporter
H5029_18270	COG0706	membrane insertase activity