locus-tag	class	description
H5028_00010	COG0592	DNA-directed DNA polymerase activity
H5028_00020	COG0187	DNA topoisomerase II activity
H5028_00030	COG0586	Pfam SNARE associated Golgi protein
H5028_00035	COG0488	(ABC) transporter
H5028_00060	COG0596	Alpha beta hydrolase
H5028_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5028_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5028_00110	COG0733	neurotransmitter:sodium symporter activity
H5028_00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5028_00145	COG0583	DNA-binding transcription factor activity
H5028_00150	COG2233	PERMEase
H5028_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5028_00200	COG2814	Major facilitator Superfamily
H5028_00205	COG0656	L-ascorbic acid biosynthetic process
H5028_00210	COG0583	DNA-binding transcription factor activity
H5028_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5028_00230	COG1064	alcohol dehydrogenase
H5028_00235	COG2818	Glycosylase
H5028_00250	COG1194	a g-specific adenine glycosylase
H5028_00270	COG2983	Belongs to the UPF0260 family
H5028_00275	COG2133	pyrroloquinoline quinone binding
H5028_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5028_00285	COG2116	formate transmembrane transporter activity
H5028_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5028_00310	COG1335	isochorismatase
H5028_00315	COG0385	Bile acid
H5028_00320	COG0534	Mate efflux family protein
H5028_00325	COG1683	Conserved Protein
H5028_00345	COG0625	glutathione transferase activity
H5028_00355	COG1113	amino acid transport
H5028_00365	COG0523	cobalamin synthesis protein
H5028_00375	COG2188	Transcriptional regulator
H5028_00405	COG0010	Belongs to the arginase family
H5028_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5028_00440	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H5028_00445	COG0732	type I restriction modification DNA specificity domain
H5028_00475	COG4584	PFAM Integrase catalytic
H5028_00505	COG2826	transposase and inactivated derivatives, IS30 family
H5028_00525	COG0673	inositol 2-dehydrogenase activity
H5028_00530	COG1324	tolerance protein
H5028_00575	COG2826	transposase and inactivated derivatives, IS30 family
H5028_00580	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H5028_00590	COG2826	transposase and inactivated derivatives, IS30 family
H5028_00640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5028_00650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5028_00655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5028_00755	COG0534	Mate efflux family protein
H5028_00760	COG0436	Aminotransferase
H5028_00765	COG2733	membrane
H5028_00780	COG2918	glutathione biosynthetic process
H5028_00795	COG1388	LysM domain
H5028_00795	COG0791	NLP P60 protein
H5028_00810	COG3150	esterase
H5028_00820	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_00825	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H5028_00835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5028_00845	COG2233	PERMEase
H5028_00850	COG2351	hydroxyisourate hydrolase activity
H5028_00885	COG3706	GGDEF domain
H5028_00900	COG1393	Belongs to the ArsC family
H5028_00905	COG0708	Exodeoxyribonuclease III
H5028_00925	COG0189	ligase activity
H5028_00945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5028_00955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5028_00970	COG4942	peptidase
H5028_00980	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5028_00990	COG2119	membrane
H5028_00995	COG4774	siderophore transport
H5028_01000	COG0426	domain, Protein
H5028_01000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5028_01025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5028_01045	COG1902	pentaerythritol trinitrate reductase activity
H5028_01050	COG1519	Transferase
H5028_01055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5028_01060	COG0668	transmembrane transport
H5028_01070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5028_01075	COG1335	isochorismatase
H5028_01080	COG1522	sequence-specific DNA binding
H5028_01085	COG3328	transposase activity
H5028_01110	COG2205	protein histidine kinase activity
H5028_01110	COG2198	Histidine kinase
H5028_01110	COG0784	Response regulator, receiver
H5028_01115	COG3162	membrane
H5028_01120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5028_01130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5028_01150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5028_01155	COG1309	transcriptional regulator
H5028_01175	COG0351	phosphomethylpyrimidine kinase
H5028_01175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5028_01175	COG0352	thiamine-phosphate diphosphorylase activity
H5028_01185	COG2814	Major facilitator Superfamily
H5028_01200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5028_01210	COG1113	amino acid transport
H5028_01220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5028_01225	COG1012	belongs to the aldehyde dehydrogenase family
H5028_01235	COG1335	isochorismatase
H5028_01265	COG2814	Major facilitator Superfamily
H5028_01270	COG0583	DNA-binding transcription factor activity
H5028_01290	COG0667	Aldo Keto reductase
H5028_01320	COG1733	regulation of RNA biosynthetic process
H5028_01325	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5028_01400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5028_01415	COG2329	Antibiotic biosynthesis monooxygenase
H5028_01445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5028_01475	COG0427	acetyl-CoA hydrolase
H5028_01500	COG0659	secondary active sulfate transmembrane transporter activity
H5028_01505	COG4221	oxidoreductase activity
H5028_01510	COG2873	o-acetylhomoserine
H5028_01515	COG0488	(ABC) transporter
H5028_01600	COG0833	amino acid
H5028_01645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5028_01650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5028_01665	COG2226	methyltransferase
H5028_01715	COG0069	glutamate synthase activity
H5028_01715	COG0070	glutamate synthase
H5028_01715	COG0067	glutamate synthase
H5028_01720	COG0493	'glutamate synthase
H5028_01730	COG1704	LemA family
H5028_01735	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H5028_01755	COG3307	-O-antigen
H5028_01775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5028_01790	COG0194	GDP metabolic process
H5028_01840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5028_01860	COG5380	lipid catabolic process
H5028_01865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5028_01890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5028_01895	COG0277	FAD linked oxidase domain protein
H5028_01905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5028_01910	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5028_01925	COG1289	transmembrane transporter activity
H5028_01935	COG0628	permease
H5028_01940	COG1192	Involved in chromosome partitioning
H5028_01970	COG0833	amino acid
H5028_01975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5028_01980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5028_01990	COG1012	belongs to the aldehyde dehydrogenase family
H5028_02030	COG0583	DNA-binding transcription factor activity
H5028_02075	COG0517	IMP dehydrogenase activity
H5028_02080	COG1983	PspC domain protein
H5028_02090	COG1960	acyl-CoA dehydrogenase activity
H5028_02105	COG0408	coproporphyrinogen oxidase activity
H5028_02125	COG0513	Belongs to the DEAD box helicase family
H5028_02135	COG1127	ABC transporter
H5028_02140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5028_02150	COG2854	intermembrane phospholipid transfer
H5028_02160	COG0598	Magnesium transport protein CorA
H5028_02170	COG0494	nUDIX hydrolase
H5028_02175	COG1040	competence protein
H5028_02180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5028_02200	COG1946	Acyl-CoA thioesterase
H5028_02205	COG1301	dicarboxylic acid transport
H5028_02220	COG1959	2 iron, 2 sulfur cluster binding
H5028_02225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5028_02225	COG1017	nitric oxide dioxygenase activity
H5028_02230	COG0433	COG0433 Predicted ATPase
H5028_02235	COG0626	cystathionine gamma-synthase activity
H5028_02390	COG1960	acyl-CoA dehydrogenase activity
H5028_02395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5028_02425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H5028_02430	COG0339	signal peptide processing
H5028_02435	COG0557	exoribonuclease II activity
H5028_02480	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5028_02485	COG2169	Transcriptional regulator
H5028_02490	COG0697	spore germination
H5028_02495	COG1295	ribonuclease BN
H5028_02530	COG1702	phosphate starvation-inducible protein PhoH
H5028_02540	COG1196	nuclear chromosome segregation
H5028_02540	COG0741	lytic transglycosylase activity
H5028_02540	COG0739	heme binding
H5028_02570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5028_02575	COG1183	phosphatidylcholine synthase activity
H5028_02620	COG1960	acyl-CoA dehydrogenase activity
H5028_02625	COG1309	transcriptional regulator
H5028_02640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5028_02645	COG1960	acyl-CoA dehydrogenase activity
H5028_02665	COG2969	positive regulation of protein catabolic process
H5028_02675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5028_02690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5028_02695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5028_02715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5028_02730	COG1408	metallophosphoesterase
H5028_02760	COG1061	Type III restriction enzyme res subunit
H5028_02835	COG1607	acyl-coa hydrolase
H5028_02865	COG2350	Protein conserved in bacteria
H5028_02875	COG0613	PHP domain protein
H5028_02880	COG3781	membrane
H5028_02890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5028_02895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5028_02905	COG1862	Preprotein translocase
H5028_02935	COG2205	protein histidine kinase activity
H5028_02940	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5028_02960	COG0726	polysaccharide deacetylase
H5028_02965	COG0463	Glycosyl transferase, family 2
H5028_02970	COG0438	transferase activity, transferring glycosyl groups
H5028_03035	COG0625	glutathione transferase activity
H5028_03040	COG0583	DNA-binding transcription factor activity
H5028_03045	COG1960	acyl-CoA dehydrogenase activity
H5028_03050	COG1960	acyl-CoA dehydrogenase activity
H5028_03060	COG2205	protein histidine kinase activity
H5028_03065	COG0745	RESPONSE REGULATOR receiver
H5028_03070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5028_03090	COG2096	Adenosyltransferase
H5028_03140	COG0285	dihydrofolate synthase activity
H5028_03160	COG0450	alkyl hydroperoxide reductase
H5028_03175	COG0477	Major facilitator Superfamily
H5028_03180	COG1272	protein, Hemolysin III
H5028_03210	COG0183	Belongs to the thiolase family
H5028_03215	COG2207	Transcriptional regulator
H5028_03235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5028_03255	COG0183	Belongs to the thiolase family
H5028_03265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5028_03265	COG2885	chlorophyll binding
H5028_03275	COG1690	Belongs to the RtcB family
H5028_03280	COG0833	amino acid
H5028_03290	COG2233	PERMEase
H5028_03295	COG1217	gtp-binding protein TYPA
H5028_03320	COG2094	Belongs to the DNA glycosylase MPG family
H5028_03325	COG4772	TonB-dependent receptor
H5028_03340	COG1902	pentaerythritol trinitrate reductase activity
H5028_03355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5028_03360	COG0354	folic acid binding
H5028_03370	COG3189	MarR family transcriptional regulator
H5028_03375	COG2824	Alkylphosphonate utilization operon protein PhnA
H5028_03380	COG3422	double-strand break repair
H5028_03420	COG0840	transmembrane signaling receptor activity
H5028_03440	COG5510	response to toxic substance
H5028_03450	COG2832	Protein of unknown function (DUF454)
H5028_03455	COG1376	ErfK ybiS ycfS ynhG family protein
H5028_03495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5028_03505	COG1289	transmembrane transporter activity
H5028_03510	COG2814	Major facilitator Superfamily
H5028_03530	COG1115	amino acid carrier protein
H5028_03535	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5028_03540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5028_03545	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H5028_03585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5028_03595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5028_03600	COG1077	Cell shape determining protein MreB Mrl
H5028_03605	COG1792	Involved in formation and maintenance of cell shape
H5028_03610	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5028_03615	COG0424	maF-like protein
H5028_03620	COG1530	ribonuclease E activity
H5028_03630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5028_03640	COG0560	Phosphoserine phosphatase
H5028_03650	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5028_03675	COG2207	Transcriptional regulator
H5028_03695	COG1113	amino acid transport
H5028_03700	COG2828	Protein conserved in bacteria
H5028_03705	COG0142	geranyltranstransferase activity
H5028_03710	COG2315	Protein conserved in bacteria
H5028_03725	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5028_03745	COG2194	sulfuric ester hydrolase activity
H5028_03750	COG0745	RESPONSE REGULATOR receiver
H5028_03755	COG0642	Histidine kinase
H5028_03765	COG0004	ammonium transporteR
H5028_03770	COG0583	DNA-binding transcription factor activity
H5028_03790	COG0525	valine-tRNA ligase activity
H5028_03800	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_03810	COG0393	Putative heavy-metal-binding
H5028_03815	COG0393	Putative heavy-metal-binding
H5028_03820	COG1538	Outer membrane efflux protein
H5028_03830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5028_03835	COG0671	phosphoesterase, PA-phosphatase related
H5028_03865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5028_03880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5028_03880	COG1648	precorrin-2 dehydrogenase activity
H5028_03885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5028_03890	COG1733	regulation of RNA biosynthetic process
H5028_03900	COG0531	amino acid
H5028_03915	COG0321	lipoyl(octanoyl) transferase activity
H5028_03920	COG2921	Belongs to the UPF0250 family
H5028_03965	COG2009	succinate dehydrogenase
H5028_03970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H5028_03975	COG1053	succinate dehydrogenase
H5028_03980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5028_04005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5028_04025	COG2354	Protein conserved in bacteria
H5028_04030	COG2321	neutral zinc metallopeptidase
H5028_04065	COG2843	Capsule synthesis protein
H5028_04080	COG0589	response to stress
H5028_04100	COG0505	Belongs to the CarA family
H5028_04125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5028_04130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5028_04180	COG0477	Major facilitator Superfamily
H5028_04185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5028_04200	COG1597	lipid kinase activity
H5028_04205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5028_04215	COG2826	transposase and inactivated derivatives, IS30 family
H5028_04245	COG0584	glycerophosphoryl diester phosphodiesterase
H5028_04265	COG0741	lytic transglycosylase activity
H5028_04285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5028_04300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5028_04325	COG0778	Nitroreductase
H5028_04340	COG1929	Belongs to the glycerate kinase type-1 family
H5028_04345	COG0243	molybdopterin cofactor binding
H5028_04350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5028_04355	COG3339	Conserved Protein
H5028_04365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5028_04380	COG1113	amino acid transport
H5028_04390	COG0019	diaminopimelate decarboxylase activity
H5028_04400	COG1280	lysine exporter protein (LysE YggA)
H5028_04405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5028_04435	COG0463	Glycosyl transferase, family 2
H5028_04455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5028_04490	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5028_04495	COG1136	(ABC) transporter
H5028_04500	COG0658	competence protein
H5028_04500	COG2333	competence protein COMEC
H5028_04510	COG0616	signal peptide processing
H5028_04510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5028_04515	COG0596	Alpha beta hydrolase
H5028_04520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5028_04530	COG0628	permease
H5028_04565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5028_04585	COG0823	Involved in the tonB-independent uptake of proteins
H5028_04605	COG0824	Thioesterase
H5028_04610	COG1473	amidohydrolase
H5028_04630	COG0047	phosphoribosylformylglycinamidine synthase activity
H5028_04630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5028_04635	COG2814	Major facilitator Superfamily
H5028_04645	COG1024	Enoyl-CoA hydratase
H5028_04650	COG1056	cytidyltransferase-related domain
H5028_04650	COG1051	belongs to the nudix hydrolase family
H5028_04660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5028_04675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5028_04690	COG4625	pathogenesis
H5028_04700	COG0583	DNA-binding transcription factor activity
H5028_04705	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H5028_04710	COG4208	sulfate ABC transporter
H5028_04715	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H5028_04725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H5028_04730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5028_04735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5028_04755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5028_04770	COG0681	Belongs to the peptidase S26 family
H5028_04785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5028_04795	COG1381	Involved in DNA repair and RecF pathway recombination
H5028_04800	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5028_04810	COG4221	oxidoreductase activity
H5028_04840	COG0436	Aminotransferase
H5028_04860	COG0556	nucleotide-excision repair
H5028_04915	COG2070	2-Nitropropane dioxygenase
H5028_04945	COG1215	transferase activity, transferring glycosyl groups
H5028_04960	COG0415	Belongs to the DNA photolyase family
H5028_04970	COG1252	NADH dehydrogenase
H5028_04975	COG1686	Belongs to the peptidase S11 family
H5028_04990	COG1187	pseudouridine synthase activity
H5028_05015	COG0477	Major facilitator Superfamily
H5028_05020	COG0583	DNA-binding transcription factor activity
H5028_05025	COG1823	symporter activity
H5028_05035	COG0612	Peptidase, M16
H5028_05060	COG0352	thiamine-phosphate diphosphorylase activity
H5028_05095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5028_05110	COG1309	transcriptional regulator
H5028_05120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5028_05125	COG0076	glutamate decarboxylase activity
H5028_05135	COG1522	sequence-specific DNA binding
H5028_05140	COG3961	Belongs to the TPP enzyme family
H5028_05145	COG1113	amino acid transport
H5028_05150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5028_05155	COG0573	inorganic phosphate transmembrane transporter activity
H5028_05165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5028_05170	COG0616	signal peptide processing
H5028_05180	COG3328	transposase activity
H5028_05210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5028_05215	COG1686	Belongs to the peptidase S11 family
H5028_05240	COG0583	DNA-binding transcription factor activity
H5028_05245	COG1067	ATP-dependent peptidase activity
H5028_05290	COG1966	Carbon starvation protein
H5028_05295	COG2879	small protein
H5028_05325	COG2508	Transcriptional regulator
H5028_05325	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H5028_05345	COG1113	amino acid transport
H5028_05355	COG0583	DNA-binding transcription factor activity
H5028_05360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5028_05365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5028_05375	COG1012	belongs to the aldehyde dehydrogenase family
H5028_05380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5028_05385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5028_05385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5028_05420	COG2814	Major facilitator Superfamily
H5028_05425	COG4948	Mandelate Racemase Muconate Lactonizing
H5028_05435	COG1309	transcriptional regulator
H5028_05455	COG1741	Belongs to the pirin family
H5028_05465	COG2964	Protein conserved in bacteria
H5028_05480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5028_05485	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5028_05490	COG4605	iron ion homeostasis
H5028_05495	COG4604	ABC transporter, ATP-binding protein
H5028_05500	COG4607	ABC-type enterochelin transport system periplasmic component
H5028_05505	COG4774	siderophore transport
H5028_05515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5028_05520	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5028_05525	COG3433	isochorismatase activity
H5028_05525	COG1535	isochorismatase
H5028_05540	COG1132	(ABC) transporter
H5028_05545	COG1132	(ABC) transporter
H5028_05550	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H5028_05560	COG1169	isochorismate synthase
H5028_05575	COG3739	integral membrane protein
H5028_05600	COG0302	gtp cyclohydrolase
H5028_05610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5028_05640	COG0308	aminopeptidase N
H5028_05645	COG0512	Glutamine amidotransferase of anthranilate synthase
H5028_05660	COG0174	glutamine synthetase
H5028_05670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5028_05705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5028_05710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5028_05715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5028_05735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5028_05740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5028_05745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5028_05760	COG1960	acyl-CoA dehydrogenase activity
H5028_05765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5028_05770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5028_05780	COG2223	nitrite transmembrane transporter activity
H5028_05790	COG0024	Methionine aminopeptidase
H5028_05795	COG0052	Belongs to the universal ribosomal protein uS2 family
H5028_05810	COG2207	Transcriptional regulator
H5028_05835	COG2951	lytic endotransglycosylase activity
H5028_05840	COG0772	Belongs to the SEDS family
H5028_05855	COG0842	Transport permease protein
H5028_05860	COG1131	(ABC) transporter
H5028_05905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5028_05920	COG4215	(ABC) transporter
H5028_05925	COG4160	amino acid transport
H5028_05930	COG4598	ABC transporter
H5028_05940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5028_05945	COG0826	peptidase U32
H5028_05950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5028_05965	COG1720	tRNA m6t6A37 methyltransferase activity
H5028_05975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5028_05990	COG0642	Histidine kinase
H5028_06000	COG0494	nUDIX hydrolase
H5028_06010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5028_06015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5028_06020	COG3139	Protein of unknown function (DUF1315)
H5028_06025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5028_06030	COG1301	dicarboxylic acid transport
H5028_06035	COG1960	acyl-CoA dehydrogenase activity
H5028_06040	COG2819	hydrolase of the alpha beta superfamily
H5028_06050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5028_06060	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5028_06065	COG1234	tRNA 3'-trailer cleavage
H5028_06095	COG2363	Small membrane protein
H5028_06115	COG0513	Belongs to the DEAD box helicase family
H5028_06125	COG0778	Nitroreductase
H5028_06155	COG1286	toxin biosynthetic process
H5028_06180	COG4783	chaperone-mediated protein folding
H5028_06185	COG1610	YqeY-like protein
H5028_06285	COG3111	PFAM Bacterial OB fold (BOF) protein
H5028_06310	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5028_06315	COG0786	glutamate:sodium symporter activity
H5028_06325	COG2186	Transcriptional regulator
H5028_06375	COG0477	Major facilitator Superfamily
H5028_06400	COG2985	domain, Protein
H5028_06410	COG2995	paraquat-inducible protein a
H5028_06415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5028_06415	COG3008	intermembrane lipid transfer
H5028_06425	COG1794	racemase activity, acting on amino acids and derivatives
H5028_06515	COG0482	sulfurtransferase activity
H5028_06530	COG0488	(ABC) transporter
H5028_06535	COG3173	Aminoglycoside phosphotransferase
H5028_06545	COG2433	Pfam Transposase IS66
H5028_06585	COG1301	dicarboxylic acid transport
H5028_06595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5028_06600	COG2011	ABC-type metal ion transport system permease component
H5028_06605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5028_06610	COG1464	Belongs to the NlpA lipoprotein family
H5028_06615	COG0151	Belongs to the GarS family
H5028_06620	COG0138	bifunctional purine biosynthesis protein purh
H5028_06625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5028_06655	COG2308	Evidence 4 Homologs of previously reported genes of
H5028_06665	COG1305	Transglutaminase-like
H5028_06675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5028_06680	COG0305	Participates in initiation and elongation during chromosome replication
H5028_06705	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5028_06715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5028_06720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5028_06745	COG0726	polysaccharide deacetylase
H5028_06745	COG1649	PFAM Uncharacterised BCR, COG1649
H5028_06750	COG1215	transferase activity, transferring glycosyl groups
H5028_06755	COG3658	cytochrome
H5028_06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5028_06780	COG0583	DNA-binding transcription factor activity
H5028_06800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5028_06805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5028_06820	COG1960	acyl-CoA dehydrogenase activity
H5028_06825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5028_06830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5028_06855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H5028_06860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5028_06870	COG2205	protein histidine kinase activity
H5028_06875	COG0745	RESPONSE REGULATOR receiver
H5028_06880	COG0174	glutamine synthetase
H5028_06900	COG0729	surface antigen
H5028_06925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5028_06930	COG2814	Major facilitator Superfamily
H5028_06945	COG0583	DNA-binding transcription factor activity
H5028_06960	COG1187	pseudouridine synthase activity
H5028_06980	COG0802	atpase or kinase
H5028_06985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5028_06995	COG1923	regulation of RNA biosynthetic process
H5028_07000	COG0697	spore germination
H5028_07015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5028_07025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5028_07030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5028_07030	COG0519	Catalyzes the synthesis of GMP from XMP
H5028_07035	COG4302	ethanolamine ammonia-lyase activity
H5028_07040	COG4303	Ethanolamine ammonia lyase large subunit
H5028_07045	COG0531	amino acid
H5028_07065	COG1454	alcohol dehydrogenase
H5028_07070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5028_07080	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H5028_07100	COG0308	aminopeptidase N
H5028_07130	COG1605	Chorismate mutase
H5028_07145	COG1309	transcriptional regulator
H5028_07155	COG0668	transmembrane transport
H5028_07195	COG4773	Receptor
H5028_07215	COG0488	(ABC) transporter
H5028_07220	COG0589	response to stress
H5028_07245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H5028_07255	COG3135	benzoate transporter
H5028_07260	COG1522	sequence-specific DNA binding
H5028_07270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5028_07275	COG0583	DNA-binding transcription factor activity
H5028_07285	COG0183	Belongs to the thiolase family
H5028_07295	COG2030	dehydratase
H5028_07300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5028_07315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5028_07325	COG0824	Thioesterase
H5028_07330	COG1454	alcohol dehydrogenase
H5028_07340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5028_07360	COG0069	glutamate synthase activity
H5028_07380	COG2814	Major facilitator Superfamily
H5028_07395	COG0511	ligase activity, forming carbon-carbon bonds
H5028_07415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5028_07415	COG1116	anion transmembrane transporter activity
H5028_07420	COG0745	RESPONSE REGULATOR receiver
H5028_07430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5028_07430	COG2146	nitrite reductase [NAD(P)H] activity
H5028_07435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5028_07440	COG0243	molybdopterin cofactor binding
H5028_07450	COG0243	molybdopterin cofactor binding
H5028_07455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5028_07470	COG0315	cyclic pyranopterin monophosphate synthase activity
H5028_07470	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5028_07475	COG0303	'Molybdopterin
H5028_07485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5028_07490	COG0697	spore germination
H5028_07510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H5028_07515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5028_07570	COG2204	response regulator
H5028_07575	COG3852	Histidine kinase
H5028_07595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5028_07600	COG0575	Belongs to the CDS family
H5028_07635	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5028_07650	COG2137	regulation of response to DNA damage stimulus
H5028_07660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5028_07665	COG1011	Hydrolase
H5028_07690	COG1522	sequence-specific DNA binding
H5028_07700	COG1113	amino acid transport
H5028_07715	COG0659	secondary active sulfate transmembrane transporter activity
H5028_07720	COG2135	peptidase activity
H5028_07735	COG5001	Diguanylate cyclase
H5028_07735	COG3300	MHYT domain
H5028_07755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5028_07755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5028_07755	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H5028_07760	COG1105	Belongs to the carbohydrate kinase PfkB family
H5028_07765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5028_07765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5028_07795	COG0024	Methionine aminopeptidase
H5028_07800	COG0583	DNA-binding transcription factor activity
H5028_07810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5028_07815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5028_07820	COG0516	GMP reductase activity
H5028_07820	COG0517	IMP dehydrogenase activity
H5028_07845	COG0552	protein localization to endoplasmic reticulum
H5028_07855	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5028_07870	COG4890	Cyd operon protein YbgT
H5028_07875	COG1294	oxidase, subunit
H5028_07895	COG1585	Membrane protein implicated in regulation of membrane protease activity
H5028_07905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5028_07910	COG4774	siderophore transport
H5028_07925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5028_07930	COG0569	domain protein
H5028_07935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5028_07965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5028_07970	COG0542	response to heat
H5028_07995	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5028_07995	COG1902	pentaerythritol trinitrate reductase activity
H5028_08040	COG2323	membrane
H5028_08045	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5028_08055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5028_08060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5028_08065	COG0183	Belongs to the thiolase family
H5028_08070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5028_08075	COG0596	Alpha beta hydrolase
H5028_08080	COG2271	Major facilitator Superfamily
H5028_08085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5028_08090	COG3485	protocatechuate 3,4-dioxygenase
H5028_08095	COG3485	protocatechuate 3,4-dioxygenase
H5028_08100	COG0710	3-dehydroquinate dehydratase activity
H5028_08105	COG3420	alginic acid biosynthetic process
H5028_08110	COG3659	wide pore channel activity
H5028_08115	COG4993	Dehydrogenase
H5028_08125	COG2391	methyltransferase activity
H5028_08140	COG1414	Transcriptional regulator
H5028_08145	COG0583	DNA-binding transcription factor activity
H5028_08150	COG1960	acyl-CoA dehydrogenase activity
H5028_08175	COG2814	Major facilitator Superfamily
H5028_08185	COG0154	amidase activity
H5028_08205	COG4638	Rieske (2fe-2S)
H5028_08215	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_08225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5028_08235	COG3733	amine oxidase
H5028_08245	COG1012	belongs to the aldehyde dehydrogenase family
H5028_08255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5028_08260	COG0183	Belongs to the thiolase family
H5028_08265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5028_08270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5028_08280	COG4829	muconolactone delta-isomerase
H5028_08285	COG4948	Mandelate Racemase Muconate Lactonizing
H5028_08290	COG0583	DNA-binding transcription factor activity
H5028_08300	COG2186	Transcriptional regulator
H5028_08320	COG1012	belongs to the aldehyde dehydrogenase family
H5028_08340	COG1960	acyl-CoA dehydrogenase activity
H5028_08345	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_08350	COG3829	transcription factor binding
H5028_08360	COG3162	membrane
H5028_08375	COG1012	belongs to the aldehyde dehydrogenase family
H5028_08390	COG0753	catalase activity
H5028_08410	COG1846	Transcriptional regulator
H5028_08415	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5028_08415	COG1902	pentaerythritol trinitrate reductase activity
H5028_08425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5028_08455	COG1309	transcriptional regulator
H5028_08465	COG1335	isochorismatase
H5028_08470	COG0583	DNA-binding transcription factor activity
H5028_08480	COG0475	glutathione-regulated potassium exporter activity
H5028_08480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5028_08490	COG1473	amidohydrolase
H5028_08500	COG2831	hemolysin activation secretion protein
H5028_08505	COG3210	domain, Protein
H5028_08535	COG2188	Transcriptional regulator
H5028_08550	COG0583	DNA-binding transcription factor activity
H5028_08580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5028_08600	COG1566	PFAM secretion protein HlyD family protein
H5028_08615	COG1012	belongs to the aldehyde dehydrogenase family
H5028_08620	COG0129	dihydroxy-acid dehydratase activity
H5028_08630	COG0583	DNA-binding transcription factor activity
H5028_08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5028_08645	COG2084	Dehydrogenase
H5028_08650	COG2207	Transcriptional regulator
H5028_08665	COG1064	alcohol dehydrogenase
H5028_08675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5028_08680	COG1120	ATPase activity
H5028_08700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5028_08815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5028_08865	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_08880	COG2207	Transcriptional regulator
H5028_08890	COG2205	protein histidine kinase activity
H5028_08895	COG0745	RESPONSE REGULATOR receiver
H5028_08900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5028_08905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5028_08910	COG1538	Outer membrane efflux protein
H5028_08920	COG2072	flavoprotein involved in K transport
H5028_08940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5028_08960	COG3539	Fimbrial protein
H5028_08990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5028_09000	COG0753	catalase activity
H5028_09015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5028_09080	COG1535	isochorismatase
H5028_09080	COG3433	isochorismatase activity
H5028_09085	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_09090	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5028_09095	COG4149	molybdate abc transporter
H5028_09100	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5028_09110	COG4638	Rieske (2fe-2S)
H5028_09115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H5028_09120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5028_09120	COG0543	2 iron, 2 sulfur cluster binding
H5028_09145	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_09160	COG2207	Transcriptional regulator
H5028_09170	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_09175	COG2610	gluconate transmembrane transporter activity
H5028_09185	COG0583	DNA-binding transcription factor activity
H5028_09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5028_09205	COG2031	fatty acid transporter
H5028_09215	COG0583	DNA-binding transcription factor activity
H5028_09220	COG0583	DNA-binding transcription factor activity
H5028_09265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5028_09285	COG2188	Transcriptional regulator
H5028_09295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5028_09300	COG1733	regulation of RNA biosynthetic process
H5028_09305	COG2207	Transcriptional regulator
H5028_09305	COG3708	Transcriptional regulator
H5028_09320	COG0730	response to heat
H5028_09330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5028_09330	COG3453	Protein conserved in bacteria
H5028_09340	COG3781	membrane
H5028_09345	COG1063	alcohol dehydrogenase
H5028_09355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5028_09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5028_09365	COG0022	dehydrogenase e1 component
H5028_09370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5028_09375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5028_09390	COG3706	GGDEF domain
H5028_09405	COG0133	tryptophan synthase activity
H5028_09415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5028_09450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5028_09475	COG2226	methyltransferase
H5028_09530	COG0842	Transport permease protein
H5028_09535	COG0842	Transport permease protein
H5028_09540	COG1131	(ABC) transporter
H5028_09555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5028_09560	COG4773	Receptor
H5028_09580	COG0730	response to heat
H5028_09585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5028_09605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5028_09620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5028_09660	COG4264	IucA IucC family
H5028_09665	COG4264	IucA IucC family
H5028_09685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5028_09700	COG1960	acyl-CoA dehydrogenase activity
H5028_09705	COG1960	acyl-CoA dehydrogenase activity
H5028_09710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5028_09715	COG2207	Transcriptional regulator
H5028_09720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5028_09725	COG0776	regulation of translation
H5028_09750	COG0822	iron-sulfur transferase activity
H5028_09755	COG0316	Belongs to the HesB IscA family
H5028_09785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5028_09805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5028_09810	COG0702	epimerase
H5028_09845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5028_09855	COG0339	signal peptide processing
H5028_09905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5028_09910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5028_09940	COG0776	regulation of translation
H5028_10005	COG0084	hydrolase, TatD family'
H5028_10025	COG1663	tetraacyldisaccharide 4'-kinase activity
H5028_10030	COG1132	(ABC) transporter
H5028_10040	COG0811	peptide transport
H5028_10045	COG1475	DNA binding
H5028_10050	COG1192	Involved in chromosome partitioning
H5028_10060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5028_10075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5028_10080	COG0191	fructose-bisphosphate aldolase activity
H5028_10100	COG0424	maF-like protein
H5028_10105	COG2850	peptidyl-arginine hydroxylation
H5028_10115	COG0640	Transcriptional regulator
H5028_10130	COG3619	membrane
H5028_10135	COG3122	Protein conserved in bacteria
H5028_10140	COG1132	(ABC) transporter
H5028_10160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5028_10165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5028_10175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5028_10175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5028_10175	COG0506	proline dehydrogenase activity
H5028_10180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H5028_10195	COG3698	Phosphodiester glycosidase
H5028_10205	COG2353	YceI-like domain
H5028_10215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5028_10260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5028_10260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5028_10285	COG3539	Fimbrial protein
H5028_10290	COG3121	Chaperone
H5028_10315	COG0697	spore germination
H5028_10325	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5028_10335	COG0583	DNA-binding transcription factor activity
H5028_10355	COG1309	transcriptional regulator
H5028_10370	COG1522	sequence-specific DNA binding
H5028_10380	COG1126	abc transporter atp-binding protein
H5028_10385	COG0765	amino acid transport
H5028_10390	COG0765	amino acid transport
H5028_10420	COG1464	Belongs to the NlpA lipoprotein family
H5028_10430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5028_10435	COG2011	ABC-type metal ion transport system permease component
H5028_10440	COG0012	GTP binding
H5028_10465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5028_10505	COG0386	Belongs to the glutathione peroxidase family
H5028_10515	COG0436	Aminotransferase
H5028_10555	COG3634	alkyl hydroperoxide reductase activity
H5028_10570	COG0583	DNA-binding transcription factor activity
H5028_10575	COG0798	PFAM Bile acid sodium symporter
H5028_10580	COG0640	Transcriptional regulator
H5028_10595	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5028_10605	COG0583	DNA-binding transcription factor activity
H5028_10615	COG1953	Uracil, thiamine, allantoin
H5028_10625	COG2175	clavaminate synthase activity
H5028_10630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5028_10635	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5028_10640	COG4521	taurine ABC transporter
H5028_10655	COG0477	Major facilitator Superfamily
H5028_10675	COG1271	oxidase subunit
H5028_10680	COG1294	oxidase, subunit
H5028_10690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5028_10710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5028_10730	COG3052	prosthetic group binding
H5028_10735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H5028_10745	COG2814	Major facilitator Superfamily
H5028_10765	COG1346	cytolysis
H5028_10775	COG0583	DNA-binding transcription factor activity
H5028_10780	COG0625	glutathione transferase activity
H5028_10785	COG0625	glutathione transferase activity
H5028_10790	COG0583	DNA-binding transcription factor activity
H5028_10805	COG1045	serine acetyltransferase
H5028_10810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5028_10815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5028_10825	COG1280	lysine exporter protein (LysE YggA)
H5028_10840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5028_10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5028_10850	COG1126	abc transporter atp-binding protein
H5028_10855	COG0765	amino acid transport
H5028_10860	COG0765	amino acid transport
H5028_10880	COG0784	Response regulator, receiver
H5028_10880	COG2205	protein histidine kinase activity
H5028_10900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5028_10920	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_10970	COG0583	DNA-binding transcription factor activity
H5028_10990	COG0318	PFAM AMP-dependent synthetase and ligase
H5028_10995	COG1309	transcriptional regulator
H5028_11000	COG1960	acyl-CoA dehydrogenase activity
H5028_11005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5028_11010	COG1024	Enoyl-CoA hydratase
H5028_11015	COG4770	biotin carboxylase activity
H5028_11025	COG0583	DNA-binding transcription factor activity
H5028_11040	COG1960	acyl-CoA dehydrogenase activity
H5028_11050	COG2814	Major facilitator Superfamily
H5028_11060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5028_11065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5028_11070	COG2814	Major facilitator Superfamily
H5028_11075	COG1960	acyl-CoA dehydrogenase activity
H5028_11080	COG1024	Enoyl-CoA hydratase
H5028_11085	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_11090	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5028_11095	COG0183	Belongs to the thiolase family
H5028_11105	COG2814	Major facilitator Superfamily
H5028_11115	COG1024	Enoyl-CoA hydratase
H5028_11130	COG1960	acyl-CoA dehydrogenase activity
H5028_11135	COG2814	Major facilitator Superfamily
H5028_11140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5028_11145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5028_11160	COG3842	ATPase activity
H5028_11165	COG1840	ABC-type Fe3 transport system, periplasmic component
H5028_11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5028_11180	COG1414	Transcriptional regulator
H5028_11190	COG0583	DNA-binding transcription factor activity
H5028_11195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5028_11200	COG1012	belongs to the aldehyde dehydrogenase family
H5028_11210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5028_11220	COG1012	belongs to the aldehyde dehydrogenase family
H5028_11225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5028_11230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5028_11235	COG2267	carboxylic ester hydrolase activity
H5028_11255	COG3038	cytochrome b561
H5028_11260	COG0753	catalase activity
H5028_11295	COG2050	protein possibly involved in aromatic compounds catabolism
H5028_11305	COG3327	negative regulation of DNA-templated transcription, initiation
H5028_11310	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H5028_11315	COG0183	Belongs to the thiolase family
H5028_11320	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5028_11325	COG1024	Enoyl-CoA hydratase
H5028_11330	COG1024	Enoyl-CoA hydratase
H5028_11335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5028_11340	COG2151	metal-sulfur cluster biosynthetic enzyme
H5028_11345	COG3396	Phenylacetate-CoA oxygenase
H5028_11350	COG3460	Phenylacetate-CoA oxygenase
H5028_11355	COG3396	Phenylacetate-CoA oxygenase
H5028_11360	COG2030	dehydratase
H5028_11360	COG1012	belongs to the aldehyde dehydrogenase family
H5028_11365	COG1760	l-serine dehydratase
H5028_11370	COG0531	amino acid
H5028_11375	COG1012	belongs to the aldehyde dehydrogenase family
H5028_11390	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5028_11400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5028_11420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5028_11430	COG0789	Transcriptional regulator
H5028_11445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5028_11460	COG2807	transmembrane transport
H5028_11465	COG0590	tRNA wobble adenosine to inosine editing
H5028_11580	COG1116	anion transmembrane transporter activity
H5028_11585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5028_11595	COG0864	Transcriptional regulator
H5028_11615	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5028_11620	COG0439	Biotin carboxylase
H5028_11635	COG1063	alcohol dehydrogenase
H5028_11645	COG1309	transcriptional regulator
H5028_11665	COG0038	chloride channel
H5028_11670	COG4770	biotin carboxylase activity
H5028_11690	COG1914	H( )-stimulated, divalent metal cation uptake system
H5028_11695	COG0583	DNA-binding transcription factor activity
H5028_11745	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5028_11765	COG2814	Major facilitator Superfamily
H5028_11775	COG1560	Kdo2-lipid A biosynthetic process
H5028_11785	COG5006	permease, DMT superfamily
H5028_11790	COG1522	sequence-specific DNA binding
H5028_11805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5028_11815	COG4122	O-methyltransferase activity
H5028_11845	COG1538	Outer membrane efflux protein
H5028_11850	COG1137	ATPase activity
H5028_11855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5028_11865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H5028_11870	COG0517	IMP dehydrogenase activity
H5028_11870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5028_11905	COG2814	Major facilitator Superfamily
H5028_11940	COG1278	Cold shock
H5028_11945	COG1280	lysine exporter protein (LysE YggA)
H5028_11975	COG1570	exodeoxyribonuclease VII activity
H5028_12025	COG0583	DNA-binding transcription factor activity
H5028_12030	COG4638	Rieske (2fe-2S)
H5028_12035	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H5028_12040	COG0633	Ferredoxin
H5028_12040	COG0543	2 iron, 2 sulfur cluster binding
H5028_12045	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_12050	COG3135	benzoate transporter
H5028_12055	COG2814	Major facilitator Superfamily
H5028_12070	COG1643	Atp-dependent helicase
H5028_12075	COG0450	alkyl hydroperoxide reductase
H5028_12085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5028_12095	COG3634	alkyl hydroperoxide reductase activity
H5028_12115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5028_12120	COG0625	glutathione transferase activity
H5028_12130	COG2885	chlorophyll binding
H5028_12165	COG0542	response to heat
H5028_12180	COG1765	OsmC-like protein
H5028_12195	COG0667	Aldo Keto reductase
H5028_12210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5028_12220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5028_12230	COG0527	aspartate kinase activity
H5028_12240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5028_12250	COG3038	cytochrome b561
H5028_12255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5028_12260	COG2252	PERMEase
H5028_12270	COG2072	flavoprotein involved in K transport
H5028_12285	COG1741	Belongs to the pirin family
H5028_12290	COG1309	transcriptional regulator
H5028_12315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5028_12355	COG1902	pentaerythritol trinitrate reductase activity
H5028_12355	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5028_12365	COG2203	Gaf domain
H5028_12365	COG5001	Diguanylate cyclase
H5028_12365	COG4251	negative regulation of phosphorylation
H5028_12365	COG3706	GGDEF domain
H5028_12375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5028_12395	COG4172	Belongs to the ABC transporter superfamily
H5028_12400	COG4239	(ABC) transporter, permease
H5028_12405	COG4174	ABC transporter (Permease)
H5028_12415	COG0741	lytic transglycosylase activity
H5028_12415	COG1388	LysM domain
H5028_12415	COG1388	LysM domain
H5028_12415	COG0741	lytic transglycosylase activity
H5028_12420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5028_12460	COG0583	DNA-binding transcription factor activity
H5028_12465	COG1279	arginine transmembrane transporter activity
H5028_12485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5028_12490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5028_12495	COG0006	proline dipeptidase activity
H5028_12530	COG2194	sulfuric ester hydrolase activity
H5028_12575	COG0739	heme binding
H5028_12900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5028_12925	COG3384	dioxygenase
H5028_12935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5028_12940	COG2878	Part of a membrane complex involved in electron transport
H5028_12945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5028_12970	COG0768	penicillin binding
H5028_12975	COG0742	ribosomal rna small subunit methyltransferase
H5028_12990	COG0830	nickel cation binding
H5028_13000	COG0804	urea catabolic process
H5028_13040	COG1253	flavin adenine dinucleotide binding
H5028_13045	COG2851	Citrate transporter
H5028_13100	COG1773	rubredoxin
H5028_13105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5028_13115	COG0583	DNA-binding transcription factor activity
H5028_13140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5028_13145	COG4181	ATPase activity
H5028_13190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5028_13210	COG0306	phosphate transporter
H5028_13220	COG3958	Transketolase
H5028_13225	COG3959	Transketolase, thiamine diphosphate binding domain
H5028_13230	COG2271	Major facilitator Superfamily
H5028_13235	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_13240	COG0583	DNA-binding transcription factor activity
H5028_13255	COG2223	nitrite transmembrane transporter activity
H5028_13260	COG2207	Transcriptional regulator
H5028_13265	COG2066	Belongs to the glutaminase family
H5028_13270	COG0242	peptide deformylase activity
H5028_13275	COG0477	Major facilitator Superfamily
H5028_13285	COG0028	Belongs to the TPP enzyme family
H5028_13300	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_13305	COG2267	carboxylic ester hydrolase activity
H5028_13315	COG2271	Major facilitator Superfamily
H5028_13320	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5028_13330	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_13350	COG1414	Transcriptional regulator
H5028_13365	COG1024	Enoyl-CoA hydratase
H5028_13375	COG1215	transferase activity, transferring glycosyl groups
H5028_13380	COG0726	polysaccharide deacetylase
H5028_13380	COG1649	PFAM Uncharacterised BCR, COG1649
H5028_13390	COG4681	YaeQ
H5028_13400	COG0523	cobalamin synthesis protein
H5028_13410	COG1607	acyl-coa hydrolase
H5028_13420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5028_13425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5028_13430	COG1309	transcriptional regulator
H5028_13455	COG2040	homocysteine
H5028_13460	COG0531	amino acid
H5028_13515	COG1595	DNA-templated transcription, initiation
H5028_13525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5028_13530	COG0477	Major facilitator Superfamily
H5028_13550	COG0084	hydrolase, TatD family'
H5028_13575	COG2826	transposase and inactivated derivatives, IS30 family
H5028_13590	COG0629	single-stranded DNA binding
H5028_13645	COG0582	viral genome integration into host DNA
H5028_13660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5028_13785	COG3566	protein conserved in bacteria
H5028_13800	COG3567	Phage-associated protein, HI1409 family
H5028_13805	COG5410	chromosome segregation
H5028_13885	COG4197	protein conserved in bacteria, prophage-related
H5028_13890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5028_13955	COG0405	Gamma-glutamyltransferase
H5028_13960	COG2814	Major facilitator Superfamily
H5028_13970	COG2050	protein possibly involved in aromatic compounds catabolism
H5028_13985	COG1090	epimerase
H5028_14005	COG0420	3'-5' exonuclease activity
H5028_14030	COG0735	belongs to the Fur family
H5028_14035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5028_14055	COG0121	glutamine amidotransferase
H5028_14070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5028_14080	COG0210	DNA helicase
H5028_14085	COG2885	chlorophyll binding
H5028_14090	COG0204	Acyl-transferase
H5028_14105	COG2894	cell division
H5028_14130	COG1280	lysine exporter protein (LysE YggA)
H5028_14135	COG1674	ftsk spoiiie
H5028_14135	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5028_14140	COG0492	ferredoxin-NADP+ reductase activity
H5028_14145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5028_14155	COG0456	acetyltransferase
H5028_14200	COG1981	membrane
H5028_14215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5028_14215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5028_14235	COG1012	belongs to the aldehyde dehydrogenase family
H5028_14245	COG0657	acetylesterase activity
H5028_14255	COG0473	3-isopropylmalate dehydrogenase activity
H5028_14260	COG0583	DNA-binding transcription factor activity
H5028_14280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5028_14305	COG0564	pseudouridine synthase activity
H5028_14315	COG0358	DNA primase activity
H5028_14330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5028_14360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5028_14390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5028_14400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5028_14400	COG0352	thiamine-phosphate diphosphorylase activity
H5028_14400	COG0351	phosphomethylpyrimidine kinase
H5028_14405	COG1652	LysM domain
H5028_14430	COG1399	metal-binding, possibly nucleic acid-binding protein
H5028_14435	COG3101	peptidyl-lysine hydroxylation
H5028_14440	COG0009	L-threonylcarbamoyladenylate synthase
H5028_14445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H5028_14450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5028_14465	COG4106	trans-aconitate 2-methyltransferase activity
H5028_14480	COG0596	Alpha beta hydrolase
H5028_14480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5028_14480	COG2226	methyltransferase
H5028_14485	COG1877	trehalose-phosphatase activity
H5028_14490	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H5028_14495	COG2223	nitrite transmembrane transporter activity
H5028_14515	COG1196	nuclear chromosome segregation
H5028_14525	COG0730	response to heat
H5028_14540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5028_14550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5028_14600	COG0489	protein tyrosine kinase activity
H5028_14610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5028_14610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5028_14640	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5028_14645	COG2081	HI0933 family
H5028_14655	COG0668	transmembrane transport
H5028_14675	COG0583	DNA-binding transcription factor activity
H5028_14695	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5028_14700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5028_14730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H5028_14770	COG0745	RESPONSE REGULATOR receiver
H5028_14790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5028_14800	COG2205	protein histidine kinase activity
H5028_14870	COG4993	Dehydrogenase
H5028_14895	COG0384	phenazine biosynthesis protein PhzF
H5028_14915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5028_14930	COG0583	DNA-binding transcription factor activity
H5028_14960	COG0583	DNA-binding transcription factor activity
H5028_14975	COG0583	DNA-binding transcription factor activity
H5028_14980	COG1053	succinate dehydrogenase
H5028_14990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5028_14995	COG2814	Major facilitator Superfamily
H5028_15000	COG1960	acyl-CoA dehydrogenase activity
H5028_15005	COG0583	DNA-binding transcription factor activity
H5028_15010	COG1063	alcohol dehydrogenase
H5028_15040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5028_15045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5028_15050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5028_15065	COG3667	copper resistance
H5028_15070	COG2132	Multicopper oxidase
H5028_15080	COG0561	phosphatase activity
H5028_15085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5028_15110	COG1214	PFAM Peptidase M22, glycoprotease
H5028_15165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5028_15175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5028_15180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5028_15185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5028_15245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5028_15255	COG1846	Transcriptional regulator
H5028_15260	COG1764	response to oxidative stress
H5028_15310	COG0037	tRNA processing
H5028_15320	COG0248	Ppx GppA phosphatase
H5028_15350	COG0072	phenylalanine-tRNA ligase activity
H5028_15390	COG1238	metal cluster binding
H5028_15395	COG0625	glutathione transferase activity
H5028_15410	COG0318	PFAM AMP-dependent synthetase and ligase
H5028_15415	COG3028	Belongs to the UPF0307 family
H5028_15420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5028_15440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5028_15445	COG0617	tRNA 3'-terminal CCA addition
H5028_15450	COG1555	photosystem II stabilization
H5028_15455	COG3956	TIGRFAM MazG family protein
H5028_15465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5028_15485	COG5002	protein histidine kinase activity
H5028_15485	COG2205	protein histidine kinase activity
H5028_15485	COG0784	Response regulator, receiver
H5028_15490	COG1024	Enoyl-CoA hydratase
H5028_15495	COG2084	Dehydrogenase
H5028_15500	COG3622	Belongs to the hyi family
H5028_15530	COG0697	spore germination
H5028_15540	COG2814	Major facilitator Superfamily
H5028_15545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5028_15555	COG0583	DNA-binding transcription factor activity
H5028_15565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5028_15575	COG0084	hydrolase, TatD family'
H5028_15590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5028_15620	COG0440	acetolactate synthase activity
H5028_15625	COG0028	Belongs to the TPP enzyme family
H5028_15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5028_15660	COG0577	efflux transmembrane transporter activity
H5028_15660	COG1136	(ABC) transporter
H5028_15665	COG1538	Outer membrane efflux protein
H5028_15680	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5028_15685	COG1162	GTPase activity
H5028_15695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5028_15735	COG1426	Protein conserved in bacteria
H5028_15770	COG0793	Belongs to the peptidase S41A family
H5028_15795	COG1012	belongs to the aldehyde dehydrogenase family
H5028_15800	COG3265	gluconokinase activity
H5028_15810	COG0800	Aldolase
H5028_15820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5028_15825	COG0280	phosphate acetyltransferase
H5028_15825	COG0857	belongs to the CobB CobQ family
H5028_15830	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H5028_15830	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H5028_15850	COG0740	serine-type endopeptidase activity
H5028_15860	COG4774	siderophore transport
H5028_15870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5028_15880	COG2813	Specifically methylates the guanine in position
H5028_15880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5028_15980	COG0788	formyltetrahydrofolate deformylase activity
H5028_16005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5028_16005	COG4651	solute:proton antiporter activity
H5028_16025	COG0724	RNA recognition motif
H5028_16030	COG0210	DNA helicase
H5028_16055	COG1733	regulation of RNA biosynthetic process
H5028_16065	COG2900	Belongs to the SlyX family
H5028_16070	COG0488	(ABC) transporter
H5028_16075	COG1280	lysine exporter protein (LysE YggA)
H5028_16080	COG1560	Kdo2-lipid A biosynthetic process
H5028_16090	COG1301	dicarboxylic acid transport
H5028_16115	COG0252	asparaginase activity
H5028_16145	COG0473	3-isopropylmalate dehydrogenase activity
H5028_16200	COG0583	DNA-binding transcription factor activity
H5028_16210	COG0625	glutathione transferase activity
H5028_16215	COG2378	regulation of single-species biofilm formation
H5028_16220	COG0546	phosphoglycolate phosphatase activity
H5028_16230	COG1530	ribonuclease E activity
H5028_16235	COG0318	PFAM AMP-dependent synthetase and ligase
H5028_16250	COG0583	DNA-binding transcription factor activity
H5028_16255	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_16260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5028_16270	COG0534	Mate efflux family protein
H5028_16285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5028_16315	COG0493	'glutamate synthase
H5028_16315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5028_16325	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5028_16330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5028_16345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5028_16355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H5028_16355	COG0644	oxidoreductase
H5028_16365	COG0425	Belongs to the sulfur carrier protein TusA family
H5028_16370	COG4535	Mg2 and Co2 transporter CorC
H5028_16380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5028_16400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5028_16405	COG0475	glutathione-regulated potassium exporter activity
H5028_16405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5028_16420	COG0484	heat shock protein binding
H5028_16425	COG0789	Transcriptional regulator
H5028_16430	COG0598	Magnesium transport protein CorA
H5028_16445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5028_16450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5028_16455	COG1074	ATP-dependent DNA helicase activity
H5028_16460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H5028_16480	COG2226	methyltransferase
H5028_16490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5028_16505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5028_16520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5028_16520	COG2111	Na H antiporter
H5028_16525	COG1006	Multisubunit Na H antiporter MnhC subunit
H5028_16530	COG0651	ATP synthesis coupled electron transport
H5028_16535	COG1863	multisubunit Na H antiporter MnhE subunit
H5028_16540	COG2212	antiporter activity
H5028_16545	COG1320	monovalent cation:proton antiporter activity
H5028_16560	COG0195	Participates in both transcription termination and antitermination
H5028_16610	COG0237	dephospho-CoA kinase activity
H5028_16620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5028_16635	COG0497	DNA recombination
H5028_16645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5028_16675	COG2169	Transcriptional regulator
H5028_16675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5028_16680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5028_16735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H5028_16750	COG0326	Molecular chaperone. Has ATPase activity
H5028_16765	COG2056	Na+-H+ antiporter family
H5028_16865	COG0546	phosphoglycolate phosphatase activity
H5028_16870	COG1716	ATPase activity
H5028_16915	COG0181	hydroxymethylbilane synthase activity
H5028_16925	COG3275	phosphorelay sensor kinase activity
H5028_16950	COG0697	spore germination
H5028_16975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5028_16980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5028_16985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5028_16990	COG0772	Belongs to the SEDS family
H5028_17015	COG4974	Belongs to the 'phage' integrase family
H5028_17020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5028_17030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5028_17040	COG2197	response regulator
H5028_17055	COG0793	Belongs to the peptidase S41A family
H5028_17060	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H5028_17065	COG0795	lipopolysaccharide-transporting ATPase activity
H5028_17105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5028_17105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5028_17115	COG0004	ammonium transporteR
H5028_17120	COG0347	Belongs to the P(II) protein family
H5028_17130	COG0606	chelatase, subunit chli
H5028_17140	COG0659	secondary active sulfate transmembrane transporter activity
H5028_17145	COG0589	response to stress
H5028_17185	COG0606	chelatase, subunit chli
H5028_17190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5028_17200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5028_17215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5028_17230	COG0318	PFAM AMP-dependent synthetase and ligase
H5028_17240	COG0477	Major facilitator Superfamily
H5028_17245	COG2860	membrane
H5028_17255	COG1253	flavin adenine dinucleotide binding
H5028_17265	COG0477	Major facilitator Superfamily
H5028_17275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5028_17310	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5028_17320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5028_17355	COG1309	transcriptional regulator
H5028_17390	COG0758	DNA mediated transformation
H5028_17400	COG0697	spore germination
H5028_17405	COG1309	transcriptional regulator
H5028_17420	COG0386	Belongs to the glutathione peroxidase family
H5028_17485	COG1121	(ABC) transporter
H5028_17490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5028_17495	COG1280	lysine exporter protein (LysE YggA)
H5028_17500	COG2837	iron assimilation
H5028_17505	COG0281	malic enzyme
H5028_17550	COG0519	Catalyzes the synthesis of GMP from XMP
H5028_17550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5028_17555	COG4399	Belongs to the UPF0754 family
H5028_17560	COG2259	Doxx family
H5028_17565	COG0586	Pfam SNARE associated Golgi protein
H5028_17580	COG1192	Involved in chromosome partitioning
H5028_17590	COG0271	Belongs to the BolA IbaG family
H5028_17630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5028_17630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5028_17630	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H5028_17630	COG3321	synthase
H5028_17635	COG1960	acyl-CoA dehydrogenase activity
H5028_17645	COG2197	response regulator
H5028_17655	COG3916	Acyl-homoserine-lactone synthase
H5028_17660	COG0477	Major facilitator Superfamily
H5028_17665	COG1024	Enoyl-CoA hydratase
H5028_17670	COG1024	Enoyl-CoA hydratase
H5028_17675	COG1960	acyl-CoA dehydrogenase activity
H5028_17680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5028_17700	COG1113	amino acid transport
H5028_17705	COG1113	amino acid transport
H5028_17710	COG0251	oxidation-reduction process
H5028_17750	COG0564	pseudouridine synthase activity
H5028_17795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5028_17810	COG1802	Transcriptional regulator
H5028_17820	COG1448	Aminotransferase
H5028_17825	COG0277	FAD linked oxidase domain protein
H5028_17835	COG2186	Transcriptional regulator
H5028_17845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5028_17855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5028_17870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5028_17875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5028_17880	COG1216	Glycosyl transferase, family 2
H5028_17895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5028_17895	COG1215	transferase activity, transferring glycosyl groups
H5028_17900	COG1442	glycosyl transferase family 8
H5028_17900	COG1216	Glycosyl transferase, family 2
H5028_17910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H5028_17915	COG1596	polysaccharide export
H5028_17940	COG0728	peptidoglycan biosynthetic process
H5028_17945	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5028_18000	COG0546	phosphoglycolate phosphatase activity
H5028_18005	COG1028	Short-chain dehydrogenase reductase Sdr
H5028_18025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5028_18030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5028_18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5028_18040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5028_18045	COG1116	anion transmembrane transporter activity
H5028_18050	COG1309	transcriptional regulator
H5028_18055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5028_18065	COG0196	riboflavin kinase activity
H5028_18070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5028_18080	COG1047	Peptidyl-prolyl cis-trans
H5028_18120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5028_18125	COG0657	acetylesterase activity
H5028_18175	COG2951	lytic endotransglycosylase activity
H5028_18180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5028_18195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5028_18205	COG0671	phosphoesterase, PA-phosphatase related
H5028_18210	COG0861	Integral membrane protein TerC family
H5028_18220	COG0754	glutathionylspermidine amidase activity
H5028_18230	COG0402	S-adenosylhomocysteine deaminase activity
H5028_18245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5028_18250	COG1230	cation diffusion facilitator family transporter
H5028_18265	COG0706	membrane insertase activity