locus-tag	class	description
KQ252_00005	COG1301	dicarboxylic acid transport
KQ252_00010	COG0436	Aminotransferase
KQ252_00020	COG0386	Belongs to the glutathione peroxidase family
KQ252_00060	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KQ252_00085	COG0012	GTP binding
KQ252_00090	COG2011	ABC-type metal ion transport system permease component
KQ252_00095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KQ252_00105	COG1464	Belongs to the NlpA lipoprotein family
KQ252_00135	COG0765	amino acid transport
KQ252_00140	COG0765	amino acid transport
KQ252_00145	COG1126	abc transporter atp-binding protein
KQ252_00155	COG1522	sequence-specific DNA binding
KQ252_00170	COG1309	transcriptional regulator
KQ252_00190	COG0583	DNA-binding transcription factor activity
KQ252_00200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KQ252_00210	COG0697	spore germination
KQ252_00235	COG3121	Chaperone
KQ252_00240	COG3539	Fimbrial protein
KQ252_00265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KQ252_00265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KQ252_00310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KQ252_00320	COG2353	YceI-like domain
KQ252_00330	COG3698	Phosphodiester glycosidase
KQ252_00345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KQ252_00350	COG0506	proline dehydrogenase activity
KQ252_00350	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KQ252_00350	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KQ252_00360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KQ252_00365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KQ252_00385	COG1132	(ABC) transporter
KQ252_00390	COG3122	Protein conserved in bacteria
KQ252_00395	COG3619	membrane
KQ252_00405	COG0640	Transcriptional regulator
KQ252_00415	COG2850	peptidyl-arginine hydroxylation
KQ252_00420	COG0424	maF-like protein
KQ252_00440	COG0191	fructose-bisphosphate aldolase activity
KQ252_00445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KQ252_00460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KQ252_00470	COG1192	Involved in chromosome partitioning
KQ252_00475	COG1475	DNA binding
KQ252_00480	COG0811	peptide transport
KQ252_00490	COG1132	(ABC) transporter
KQ252_00495	COG1663	tetraacyldisaccharide 4'-kinase activity
KQ252_00515	COG0084	hydrolase, TatD family'
KQ252_00580	COG0776	regulation of translation
KQ252_00610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KQ252_00615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KQ252_00665	COG0339	signal peptide processing
KQ252_00675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KQ252_00710	COG0702	epimerase
KQ252_00715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KQ252_00735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KQ252_00765	COG0316	Belongs to the HesB IscA family
KQ252_00770	COG0822	iron-sulfur transferase activity
KQ252_00795	COG0776	regulation of translation
KQ252_00800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KQ252_00805	COG2207	Transcriptional regulator
KQ252_00810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KQ252_00815	COG1960	acyl-CoA dehydrogenase activity
KQ252_00820	COG1960	acyl-CoA dehydrogenase activity
KQ252_00835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KQ252_00855	COG4264	IucA IucC family
KQ252_00860	COG4264	IucA IucC family
KQ252_00900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KQ252_00915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KQ252_00920	COG0406	alpha-ribazole phosphatase activity
KQ252_00935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KQ252_00940	COG0730	response to heat
KQ252_00960	COG4773	Receptor
KQ252_00965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KQ252_00980	COG1131	(ABC) transporter
KQ252_00985	COG0842	Transport permease protein
KQ252_00990	COG0842	Transport permease protein
KQ252_01045	COG2226	methyltransferase
KQ252_01070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KQ252_01105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KQ252_01115	COG0133	tryptophan synthase activity
KQ252_01130	COG3706	GGDEF domain
KQ252_01145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KQ252_01150	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KQ252_01155	COG0022	dehydrogenase e1 component
KQ252_01160	COG0508	dehydrogenase complex catalyzes the overall conversion of
KQ252_01165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KQ252_01175	COG1063	alcohol dehydrogenase
KQ252_01180	COG3781	membrane
KQ252_01190	COG3453	Protein conserved in bacteria
KQ252_01190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KQ252_01200	COG0730	response to heat
KQ252_01215	COG3708	Transcriptional regulator
KQ252_01215	COG2207	Transcriptional regulator
KQ252_01220	COG1733	regulation of RNA biosynthetic process
KQ252_01225	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KQ252_01235	COG2188	Transcriptional regulator
KQ252_01250	COG4521	taurine ABC transporter
KQ252_01255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KQ252_01275	COG0477	Major facilitator Superfamily
KQ252_01285	COG1027	Aspartate ammonia-lyase
KQ252_01300	COG0583	DNA-binding transcription factor activity
KQ252_01305	COG0583	DNA-binding transcription factor activity
KQ252_01310	COG0183	Belongs to the thiolase family
KQ252_01315	COG2031	fatty acid transporter
KQ252_01330	COG0583	DNA-binding transcription factor activity
KQ252_01340	COG2610	gluconate transmembrane transporter activity
KQ252_01345	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_01350	COG2207	Transcriptional regulator
KQ252_01365	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_01375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KQ252_01390	COG0543	2 iron, 2 sulfur cluster binding
KQ252_01390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KQ252_01395	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KQ252_01400	COG4638	Rieske (2fe-2S)
KQ252_01410	COG0725	ABC transporter, periplasmic molybdate-binding protein
KQ252_01415	COG4149	molybdate abc transporter
KQ252_01420	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KQ252_01425	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_01430	COG1535	isochorismatase
KQ252_01430	COG3433	isochorismatase activity
KQ252_01495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KQ252_01510	COG0753	catalase activity
KQ252_01520	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KQ252_01545	COG3539	Fimbrial protein
KQ252_01560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KQ252_01565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KQ252_01570	COG0745	RESPONSE REGULATOR receiver
KQ252_01575	COG2205	protein histidine kinase activity
KQ252_01585	COG2207	Transcriptional regulator
KQ252_01595	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_01620	COG4372	Transposase
KQ252_01655	COG2186	Transcriptional regulator
KQ252_01665	COG0583	DNA-binding transcription factor activity
KQ252_01670	COG4948	Mandelate Racemase Muconate Lactonizing
KQ252_01675	COG4829	muconolactone delta-isomerase
KQ252_01685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KQ252_01690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KQ252_01695	COG0183	Belongs to the thiolase family
KQ252_01700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KQ252_01710	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_01730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KQ252_01740	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_01750	COG4638	Rieske (2fe-2S)
KQ252_01770	COG0154	amidase activity
KQ252_01780	COG2814	Major facilitator Superfamily
KQ252_01805	COG1960	acyl-CoA dehydrogenase activity
KQ252_01810	COG0583	DNA-binding transcription factor activity
KQ252_01815	COG1414	Transcriptional regulator
KQ252_01830	COG2391	methyltransferase activity
KQ252_01840	COG4993	Dehydrogenase
KQ252_01845	COG3659	wide pore channel activity
KQ252_01850	COG3420	alginic acid biosynthetic process
KQ252_01855	COG0710	3-dehydroquinate dehydratase activity
KQ252_01860	COG3485	protocatechuate 3,4-dioxygenase
KQ252_01865	COG3485	protocatechuate 3,4-dioxygenase
KQ252_01870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KQ252_01875	COG2271	Major facilitator Superfamily
KQ252_01880	COG0596	Alpha beta hydrolase
KQ252_01885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KQ252_01890	COG0183	Belongs to the thiolase family
KQ252_01895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KQ252_01900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KQ252_01910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KQ252_01915	COG2323	membrane
KQ252_01960	COG1902	pentaerythritol trinitrate reductase activity
KQ252_01960	COG0446	pyridine nucleotide-disulphide oxidoreductase
KQ252_01985	COG0542	response to heat
KQ252_01990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KQ252_02020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KQ252_02025	COG0569	domain protein
KQ252_02030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KQ252_02045	COG4774	siderophore transport
KQ252_02050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KQ252_02060	COG1585	Membrane protein implicated in regulation of membrane protease activity
KQ252_02065	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_02080	COG1294	oxidase, subunit
KQ252_02085	COG4890	Cyd operon protein YbgT
KQ252_02100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KQ252_02110	COG0552	protein localization to endoplasmic reticulum
KQ252_02135	COG0517	IMP dehydrogenase activity
KQ252_02135	COG0516	GMP reductase activity
KQ252_02140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KQ252_02145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KQ252_02155	COG0583	DNA-binding transcription factor activity
KQ252_02160	COG0024	Methionine aminopeptidase
KQ252_02190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KQ252_02190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KQ252_02195	COG1105	Belongs to the carbohydrate kinase PfkB family
KQ252_02200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KQ252_02200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KQ252_02200	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KQ252_02220	COG5001	Diguanylate cyclase
KQ252_02220	COG3300	MHYT domain
KQ252_02235	COG2135	peptidase activity
KQ252_02240	COG4372	Transposase
KQ252_02255	COG0659	secondary active sulfate transmembrane transporter activity
KQ252_02270	COG1113	amino acid transport
KQ252_02280	COG1522	sequence-specific DNA binding
KQ252_02305	COG1011	Hydrolase
KQ252_02310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KQ252_02320	COG2137	regulation of response to DNA damage stimulus
KQ252_02335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KQ252_02370	COG0575	Belongs to the CDS family
KQ252_02375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KQ252_02395	COG3852	Histidine kinase
KQ252_02400	COG2204	response regulator
KQ252_02455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KQ252_02460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KQ252_02480	COG0697	spore germination
KQ252_02485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KQ252_02495	COG0303	'Molybdopterin
KQ252_02500	COG0521	Mo-molybdopterin cofactor biosynthetic process
KQ252_02500	COG0315	cyclic pyranopterin monophosphate synthase activity
KQ252_02515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KQ252_02520	COG0243	molybdopterin cofactor binding
KQ252_02530	COG0243	molybdopterin cofactor binding
KQ252_02535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KQ252_02540	COG2146	nitrite reductase [NAD(P)H] activity
KQ252_02540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KQ252_02550	COG0745	RESPONSE REGULATOR receiver
KQ252_02555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KQ252_02555	COG1116	anion transmembrane transporter activity
KQ252_02570	COG0511	ligase activity, forming carbon-carbon bonds
KQ252_02585	COG2814	Major facilitator Superfamily
KQ252_02710	COG0592	DNA-directed DNA polymerase activity
KQ252_02750	COG2026	Addiction module toxin, RelE StbE family
KQ252_02955	COG1484	DNA-dependent DNA replication
KQ252_03050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KQ252_03110	COG0069	glutamate synthase activity
KQ252_03130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KQ252_03140	COG1454	alcohol dehydrogenase
KQ252_03145	COG0824	Thioesterase
KQ252_03160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KQ252_03175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KQ252_03180	COG2030	dehydratase
KQ252_03190	COG0183	Belongs to the thiolase family
KQ252_03200	COG0583	DNA-binding transcription factor activity
KQ252_03205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KQ252_03215	COG1522	sequence-specific DNA binding
KQ252_03220	COG3135	benzoate transporter
KQ252_03230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KQ252_03250	COG0589	response to stress
KQ252_03255	COG0488	(ABC) transporter
KQ252_03275	COG4773	Receptor
KQ252_03305	COG0668	transmembrane transport
KQ252_03330	COG1605	Chorismate mutase
KQ252_03360	COG4372	Transposase
KQ252_03395	COG0308	aminopeptidase N
KQ252_03420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KQ252_03425	COG1454	alcohol dehydrogenase
KQ252_03445	COG0531	amino acid
KQ252_03450	COG4303	Ethanolamine ammonia lyase large subunit
KQ252_03455	COG4302	ethanolamine ammonia-lyase activity
KQ252_03460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KQ252_03460	COG0519	Catalyzes the synthesis of GMP from XMP
KQ252_03465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KQ252_03490	COG0697	spore germination
KQ252_03495	COG1923	regulation of RNA biosynthetic process
KQ252_03505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KQ252_03510	COG0802	atpase or kinase
KQ252_03530	COG1187	pseudouridine synthase activity
KQ252_03545	COG0583	DNA-binding transcription factor activity
KQ252_03560	COG2814	Major facilitator Superfamily
KQ252_03565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KQ252_03590	COG0729	surface antigen
KQ252_03610	COG0174	glutamine synthetase
KQ252_03615	COG0745	RESPONSE REGULATOR receiver
KQ252_03620	COG2205	protein histidine kinase activity
KQ252_03630	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KQ252_03635	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KQ252_03660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KQ252_03665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KQ252_03670	COG1960	acyl-CoA dehydrogenase activity
KQ252_03700	COG0583	DNA-binding transcription factor activity
KQ252_03715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KQ252_03725	COG3658	cytochrome
KQ252_03735	COG1649	PFAM Uncharacterised BCR, COG1649
KQ252_03735	COG0726	polysaccharide deacetylase
KQ252_03760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KQ252_03765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KQ252_03775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KQ252_03800	COG0305	Participates in initiation and elongation during chromosome replication
KQ252_03805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KQ252_03815	COG1305	Transglutaminase-like
KQ252_03825	COG2308	Evidence 4 Homologs of previously reported genes of
KQ252_03855	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KQ252_03860	COG0138	bifunctional purine biosynthesis protein purh
KQ252_03865	COG0151	Belongs to the GarS family
KQ252_03870	COG1464	Belongs to the NlpA lipoprotein family
KQ252_03875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KQ252_03880	COG2011	ABC-type metal ion transport system permease component
KQ252_03885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KQ252_03895	COG1301	dicarboxylic acid transport
KQ252_03925	COG1794	racemase activity, acting on amino acids and derivatives
KQ252_03930	COG0492	ferredoxin-NADP+ reductase activity
KQ252_03930	COG3118	belongs to the thioredoxin family
KQ252_03945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KQ252_03945	COG3008	intermembrane lipid transfer
KQ252_03950	COG2995	paraquat-inducible protein a
KQ252_03975	COG0477	Major facilitator Superfamily
KQ252_04020	COG2186	Transcriptional regulator
KQ252_04030	COG0786	glutamate:sodium symporter activity
KQ252_04035	COG3243	poly(R)-hydroxyalkanoic acid synthase
KQ252_04065	COG3111	PFAM Bacterial OB fold (BOF) protein
KQ252_04135	COG3210	domain, Protein
KQ252_04140	COG2831	hemolysin activation secretion protein
KQ252_04195	COG1610	YqeY-like protein
KQ252_04200	COG4783	chaperone-mediated protein folding
KQ252_04225	COG1286	toxin biosynthetic process
KQ252_04255	COG0778	Nitroreductase
KQ252_04265	COG0513	Belongs to the DEAD box helicase family
KQ252_04285	COG2363	Small membrane protein
KQ252_04315	COG1234	tRNA 3'-trailer cleavage
KQ252_04320	COG2195	Cleaves the N-terminal amino acid of tripeptides
KQ252_04330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KQ252_04345	COG1960	acyl-CoA dehydrogenase activity
KQ252_04350	COG1301	dicarboxylic acid transport
KQ252_04355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KQ252_04360	COG3139	Protein of unknown function (DUF1315)
KQ252_04365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KQ252_04370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KQ252_04380	COG0494	nUDIX hydrolase
KQ252_04390	COG0642	Histidine kinase
KQ252_04405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KQ252_04415	COG1720	tRNA m6t6A37 methyltransferase activity
KQ252_04430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KQ252_04435	COG0826	peptidase U32
KQ252_04440	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KQ252_04450	COG4598	ABC transporter
KQ252_04455	COG4160	amino acid transport
KQ252_04460	COG4215	(ABC) transporter
KQ252_04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KQ252_04520	COG1131	(ABC) transporter
KQ252_04525	COG0842	Transport permease protein
KQ252_04540	COG0772	Belongs to the SEDS family
KQ252_04545	COG2951	lytic endotransglycosylase activity
KQ252_04570	COG2207	Transcriptional regulator
KQ252_04585	COG0052	Belongs to the universal ribosomal protein uS2 family
KQ252_04590	COG0024	Methionine aminopeptidase
KQ252_04600	COG2223	nitrite transmembrane transporter activity
KQ252_04610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KQ252_04615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KQ252_04620	COG1960	acyl-CoA dehydrogenase activity
KQ252_04635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KQ252_04640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KQ252_04645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KQ252_04665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KQ252_04670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KQ252_04675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KQ252_04710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KQ252_04720	COG0174	glutamine synthetase
KQ252_04735	COG0582	viral genome integration into host DNA
KQ252_04855	COG3566	protein conserved in bacteria
KQ252_04875	COG3567	Phage-associated protein, HI1409 family
KQ252_04880	COG5410	chromosome segregation
KQ252_04970	COG0305	Participates in initiation and elongation during chromosome replication
KQ252_05070	COG0512	Glutamine amidotransferase of anthranilate synthase
KQ252_05105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KQ252_05115	COG0302	gtp cyclohydrolase
KQ252_05140	COG3739	integral membrane protein
KQ252_05155	COG1169	isochorismate synthase
KQ252_05165	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KQ252_05170	COG1132	(ABC) transporter
KQ252_05175	COG1132	(ABC) transporter
KQ252_05185	COG1535	isochorismatase
KQ252_05185	COG3433	isochorismatase activity
KQ252_05190	COG1021	2,3-dihydroxybenzoate-AMP ligase
KQ252_05195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KQ252_05205	COG4774	siderophore transport
KQ252_05210	COG4607	ABC-type enterochelin transport system periplasmic component
KQ252_05215	COG4604	ABC transporter, ATP-binding protein
KQ252_05220	COG4605	iron ion homeostasis
KQ252_05225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KQ252_05230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KQ252_05245	COG2964	Protein conserved in bacteria
KQ252_05265	COG0582	viral genome integration into host DNA
KQ252_05275	COG2879	small protein
KQ252_05280	COG1966	Carbon starvation protein
KQ252_05300	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KQ252_05325	COG1067	ATP-dependent peptidase activity
KQ252_05330	COG0583	DNA-binding transcription factor activity
KQ252_05355	COG1686	Belongs to the peptidase S11 family
KQ252_05360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KQ252_05395	COG0616	signal peptide processing
KQ252_05400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KQ252_05410	COG0573	inorganic phosphate transmembrane transporter activity
KQ252_05415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KQ252_05420	COG1113	amino acid transport
KQ252_05425	COG3961	Belongs to the TPP enzyme family
KQ252_05430	COG1522	sequence-specific DNA binding
KQ252_05440	COG0076	glutamate decarboxylase activity
KQ252_05445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KQ252_05455	COG1309	transcriptional regulator
KQ252_05470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KQ252_05505	COG0352	thiamine-phosphate diphosphorylase activity
KQ252_05530	COG0612	Peptidase, M16
KQ252_05540	COG1823	symporter activity
KQ252_05545	COG0583	DNA-binding transcription factor activity
KQ252_05550	COG0477	Major facilitator Superfamily
KQ252_05585	COG1187	pseudouridine synthase activity
KQ252_05600	COG1686	Belongs to the peptidase S11 family
KQ252_05605	COG1252	NADH dehydrogenase
KQ252_05615	COG0415	Belongs to the DNA photolyase family
KQ252_05630	COG1215	transferase activity, transferring glycosyl groups
KQ252_05660	COG2070	2-Nitropropane dioxygenase
KQ252_05715	COG0556	nucleotide-excision repair
KQ252_05735	COG0436	Aminotransferase
KQ252_05765	COG4221	oxidoreductase activity
KQ252_05775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KQ252_05780	COG1381	Involved in DNA repair and RecF pathway recombination
KQ252_05790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KQ252_05805	COG0681	Belongs to the peptidase S26 family
KQ252_05815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KQ252_05825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KQ252_05845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KQ252_05850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KQ252_05855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KQ252_05865	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KQ252_05870	COG4208	sulfate ABC transporter
KQ252_05875	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KQ252_05880	COG0583	DNA-binding transcription factor activity
KQ252_05885	COG4625	pathogenesis
KQ252_05900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KQ252_05915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KQ252_05925	COG1056	cytidyltransferase-related domain
KQ252_05925	COG1051	belongs to the nudix hydrolase family
KQ252_05930	COG1024	Enoyl-CoA hydratase
KQ252_05940	COG2814	Major facilitator Superfamily
KQ252_05945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KQ252_05945	COG0047	phosphoribosylformylglycinamidine synthase activity
KQ252_05965	COG1473	amidohydrolase
KQ252_05970	COG0824	Thioesterase
KQ252_05990	COG0823	Involved in the tonB-independent uptake of proteins
KQ252_06010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KQ252_06045	COG0628	permease
KQ252_06055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KQ252_06060	COG0596	Alpha beta hydrolase
KQ252_06065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KQ252_06065	COG0616	signal peptide processing
KQ252_06080	COG1136	(ABC) transporter
KQ252_06085	COG4591	ABC-type transport system involved in lipoprotein release permease component
KQ252_06120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KQ252_06140	COG0463	Glycosyl transferase, family 2
KQ252_06170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KQ252_06175	COG1280	lysine exporter protein (LysE YggA)
KQ252_06185	COG0019	diaminopimelate decarboxylase activity
KQ252_06195	COG1113	amino acid transport
KQ252_06210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KQ252_06220	COG3339	Conserved Protein
KQ252_06225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KQ252_06230	COG0243	molybdopterin cofactor binding
KQ252_06235	COG1929	Belongs to the glycerate kinase type-1 family
KQ252_06250	COG0778	Nitroreductase
KQ252_06270	COG3811	Belongs to the UPF0386 family
KQ252_06280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KQ252_06295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KQ252_06315	COG0741	lytic transglycosylase activity
KQ252_06335	COG0584	glycerophosphoryl diester phosphodiesterase
KQ252_06340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KQ252_06395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KQ252_06400	COG1597	lipid kinase activity
KQ252_06415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KQ252_06420	COG0477	Major facilitator Superfamily
KQ252_06470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KQ252_06475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KQ252_06500	COG0505	Belongs to the CarA family
KQ252_06515	COG1309	transcriptional regulator
KQ252_06520	COG0251	oxidation-reduction process
KQ252_06530	COG0589	response to stress
KQ252_06545	COG2843	Capsule synthesis protein
KQ252_06580	COG2321	neutral zinc metallopeptidase
KQ252_06585	COG2354	Protein conserved in bacteria
KQ252_06605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KQ252_06630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KQ252_06635	COG1053	succinate dehydrogenase
KQ252_06640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KQ252_06645	COG2009	succinate dehydrogenase
KQ252_06680	COG2921	Belongs to the UPF0250 family
KQ252_06685	COG0321	lipoyl(octanoyl) transferase activity
KQ252_06700	COG0531	amino acid
KQ252_06710	COG1733	regulation of RNA biosynthetic process
KQ252_06715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KQ252_06720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KQ252_06720	COG1648	precorrin-2 dehydrogenase activity
KQ252_06735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KQ252_06765	COG0671	phosphoesterase, PA-phosphatase related
KQ252_06770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KQ252_06780	COG1538	Outer membrane efflux protein
KQ252_06785	COG0393	Putative heavy-metal-binding
KQ252_06790	COG0393	Putative heavy-metal-binding
KQ252_06800	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_06810	COG0525	valine-tRNA ligase activity
KQ252_06830	COG0583	DNA-binding transcription factor activity
KQ252_06835	COG0004	ammonium transporteR
KQ252_06845	COG0642	Histidine kinase
KQ252_06850	COG0745	RESPONSE REGULATOR receiver
KQ252_06855	COG2194	sulfuric ester hydrolase activity
KQ252_06875	COG1752	Esterase of the alpha-beta hydrolase superfamily
KQ252_06890	COG2315	Protein conserved in bacteria
KQ252_06895	COG0142	geranyltranstransferase activity
KQ252_06900	COG2828	Protein conserved in bacteria
KQ252_06905	COG1113	amino acid transport
KQ252_06925	COG2207	Transcriptional regulator
KQ252_06950	COG2249	NAD(P)H dehydrogenase (quinone) activity
KQ252_06960	COG0560	Phosphoserine phosphatase
KQ252_06970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KQ252_06980	COG1530	ribonuclease E activity
KQ252_06985	COG0424	maF-like protein
KQ252_06990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KQ252_06995	COG1792	Involved in formation and maintenance of cell shape
KQ252_07000	COG1077	Cell shape determining protein MreB Mrl
KQ252_07005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KQ252_07015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KQ252_07040	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KQ252_07045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KQ252_07050	COG1752	Esterase of the alpha-beta hydrolase superfamily
KQ252_07055	COG1115	amino acid carrier protein
KQ252_07075	COG2814	Major facilitator Superfamily
KQ252_07080	COG1289	transmembrane transporter activity
KQ252_07090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KQ252_07130	COG1376	ErfK ybiS ycfS ynhG family protein
KQ252_07135	COG2832	Protein of unknown function (DUF454)
KQ252_07145	COG5510	response to toxic substance
KQ252_07165	COG0840	transmembrane signaling receptor activity
KQ252_07205	COG3422	double-strand break repair
KQ252_07210	COG2824	Alkylphosphonate utilization operon protein PhnA
KQ252_07215	COG3189	MarR family transcriptional regulator
KQ252_07225	COG0354	folic acid binding
KQ252_07230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KQ252_07240	COG0679	Auxin Efflux Carrier
KQ252_07245	COG1902	pentaerythritol trinitrate reductase activity
KQ252_07250	COG4772	TonB-dependent receptor
KQ252_07255	COG2094	Belongs to the DNA glycosylase MPG family
KQ252_07280	COG1217	gtp-binding protein TYPA
KQ252_07285	COG2233	PERMEase
KQ252_07295	COG0833	amino acid
KQ252_07300	COG1690	Belongs to the RtcB family
KQ252_07310	COG2885	chlorophyll binding
KQ252_07310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KQ252_07320	COG0183	Belongs to the thiolase family
KQ252_07340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KQ252_07360	COG2207	Transcriptional regulator
KQ252_07365	COG0183	Belongs to the thiolase family
KQ252_07395	COG1272	protein, Hemolysin III
KQ252_07400	COG0477	Major facilitator Superfamily
KQ252_07415	COG0450	alkyl hydroperoxide reductase
KQ252_07435	COG0285	dihydrofolate synthase activity
KQ252_07485	COG2096	Adenosyltransferase
KQ252_07490	COG0584	glycerophosphoryl diester phosphodiesterase
KQ252_07505	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KQ252_07510	COG0745	RESPONSE REGULATOR receiver
KQ252_07515	COG2205	protein histidine kinase activity
KQ252_07525	COG1960	acyl-CoA dehydrogenase activity
KQ252_07530	COG1960	acyl-CoA dehydrogenase activity
KQ252_07595	COG0438	transferase activity, transferring glycosyl groups
KQ252_07600	COG0463	Glycosyl transferase, family 2
KQ252_07605	COG0726	polysaccharide deacetylase
KQ252_07625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KQ252_07630	COG2205	protein histidine kinase activity
KQ252_07660	COG1862	Preprotein translocase
KQ252_07670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KQ252_07675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KQ252_07685	COG3781	membrane
KQ252_07690	COG0613	PHP domain protein
KQ252_07700	COG2350	Protein conserved in bacteria
KQ252_07730	COG1607	acyl-coa hydrolase
KQ252_07790	COG2199	diguanylate cyclase activity
KQ252_07800	COG1408	metallophosphoesterase
KQ252_07805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KQ252_07815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KQ252_07835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KQ252_07840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KQ252_07845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KQ252_07855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KQ252_07865	COG2969	positive regulation of protein catabolic process
KQ252_07885	COG1960	acyl-CoA dehydrogenase activity
KQ252_07890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KQ252_07905	COG1309	transcriptional regulator
KQ252_07910	COG1960	acyl-CoA dehydrogenase activity
KQ252_07955	COG1183	phosphatidylcholine synthase activity
KQ252_07960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KQ252_07990	COG0739	heme binding
KQ252_07990	COG0741	lytic transglycosylase activity
KQ252_07990	COG1196	nuclear chromosome segregation
KQ252_08000	COG1702	phosphate starvation-inducible protein PhoH
KQ252_08035	COG1295	ribonuclease BN
KQ252_08040	COG0697	spore germination
KQ252_08045	COG2169	Transcriptional regulator
KQ252_08050	COG0179	Fumarylacetoacetate (FAA) hydrolase
KQ252_08095	COG0557	exoribonuclease II activity
KQ252_08100	COG0339	signal peptide processing
KQ252_08105	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KQ252_08135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KQ252_08140	COG1960	acyl-CoA dehydrogenase activity
KQ252_08295	COG0626	cystathionine gamma-synthase activity
KQ252_08300	COG0433	COG0433 Predicted ATPase
KQ252_08310	COG1017	nitric oxide dioxygenase activity
KQ252_08310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KQ252_08315	COG1959	2 iron, 2 sulfur cluster binding
KQ252_08330	COG1301	dicarboxylic acid transport
KQ252_08335	COG1946	Acyl-CoA thioesterase
KQ252_08355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KQ252_08360	COG1040	competence protein
KQ252_08365	COG0494	nUDIX hydrolase
KQ252_08375	COG0598	Magnesium transport protein CorA
KQ252_08385	COG2854	intermembrane phospholipid transfer
KQ252_08395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KQ252_08400	COG1127	ABC transporter
KQ252_08410	COG0513	Belongs to the DEAD box helicase family
KQ252_08430	COG0408	coproporphyrinogen oxidase activity
KQ252_08445	COG1960	acyl-CoA dehydrogenase activity
KQ252_08455	COG1983	PspC domain protein
KQ252_08460	COG0517	IMP dehydrogenase activity
KQ252_08505	COG0583	DNA-binding transcription factor activity
KQ252_08545	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_08555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KQ252_08560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KQ252_08565	COG0833	amino acid
KQ252_08570	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_08600	COG1192	Involved in chromosome partitioning
KQ252_08605	COG0628	permease
KQ252_08615	COG1289	transmembrane transporter activity
KQ252_08630	COG2249	NAD(P)H dehydrogenase (quinone) activity
KQ252_08635	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KQ252_08645	COG0277	FAD linked oxidase domain protein
KQ252_08650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KQ252_08675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KQ252_08680	COG5380	lipid catabolic process
KQ252_08700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KQ252_08750	COG0194	GDP metabolic process
KQ252_08765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KQ252_08785	COG3307	-O-antigen
KQ252_08795	COG4969	Belongs to the N-Me-Phe pilin family
KQ252_08805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KQ252_08810	COG1704	LemA family
KQ252_08820	COG0493	'glutamate synthase
KQ252_08825	COG0070	glutamate synthase
KQ252_08825	COG0067	glutamate synthase
KQ252_08825	COG0069	glutamate synthase activity
KQ252_08875	COG2226	methyltransferase
KQ252_08890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KQ252_08895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KQ252_08940	COG0833	amino acid
KQ252_09005	COG0488	(ABC) transporter
KQ252_09010	COG2873	o-acetylhomoserine
KQ252_09015	COG4221	oxidoreductase activity
KQ252_09020	COG0659	secondary active sulfate transmembrane transporter activity
KQ252_09045	COG0427	acetyl-CoA hydrolase
KQ252_09075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KQ252_09115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KQ252_09170	COG0582	viral genome integration into host DNA
KQ252_09205	COG0305	Participates in initiation and elongation during chromosome replication
KQ252_09280	COG4372	Transposase
KQ252_09315	COG4372	Transposase
KQ252_09355	COG2249	NAD(P)H dehydrogenase (quinone) activity
KQ252_09360	COG1733	regulation of RNA biosynthetic process
KQ252_09400	COG0667	Aldo Keto reductase
KQ252_09420	COG0583	DNA-binding transcription factor activity
KQ252_09425	COG2814	Major facilitator Superfamily
KQ252_09455	COG1335	isochorismatase
KQ252_09465	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_09470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KQ252_09480	COG1113	amino acid transport
KQ252_09490	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KQ252_09505	COG2814	Major facilitator Superfamily
KQ252_09515	COG0351	phosphomethylpyrimidine kinase
KQ252_09515	COG0352	thiamine-phosphate diphosphorylase activity
KQ252_09515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KQ252_09535	COG1309	transcriptional regulator
KQ252_09540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KQ252_09555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KQ252_09580	COG3162	membrane
KQ252_09585	COG0784	Response regulator, receiver
KQ252_09585	COG2198	Histidine kinase
KQ252_09585	COG2205	protein histidine kinase activity
KQ252_09610	COG1522	sequence-specific DNA binding
KQ252_09615	COG1335	isochorismatase
KQ252_09620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KQ252_09630	COG0668	transmembrane transport
KQ252_09635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KQ252_09640	COG1519	Transferase
KQ252_09645	COG1902	pentaerythritol trinitrate reductase activity
KQ252_09670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KQ252_09695	COG0426	domain, Protein
KQ252_09695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KQ252_09700	COG4774	siderophore transport
KQ252_09705	COG2119	membrane
KQ252_09715	COG0508	dehydrogenase complex catalyzes the overall conversion of
KQ252_09725	COG4942	peptidase
KQ252_09740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KQ252_09750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KQ252_09770	COG0189	ligase activity
KQ252_09790	COG0708	Exodeoxyribonuclease III
KQ252_09795	COG1393	Belongs to the ArsC family
KQ252_09810	COG3706	GGDEF domain
KQ252_09845	COG2351	hydroxyisourate hydrolase activity
KQ252_09850	COG2233	PERMEase
KQ252_09860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KQ252_09870	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KQ252_09875	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_09885	COG3150	esterase
KQ252_09925	COG2918	glutathione biosynthetic process
KQ252_09940	COG2733	membrane
KQ252_09945	COG0436	Aminotransferase
KQ252_09950	COG0534	Mate efflux family protein
KQ252_09980	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_10015	COG0753	catalase activity
KQ252_10060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KQ252_10065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KQ252_10075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KQ252_10080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KQ252_10095	COG0010	Belongs to the arginase family
KQ252_10125	COG2188	Transcriptional regulator
KQ252_10135	COG0523	cobalamin synthesis protein
KQ252_10145	COG1113	amino acid transport
KQ252_10155	COG0625	glutathione transferase activity
KQ252_10175	COG1683	Conserved Protein
KQ252_10180	COG0534	Mate efflux family protein
KQ252_10185	COG0385	Bile acid
KQ252_10190	COG1335	isochorismatase
KQ252_10195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KQ252_10215	COG2116	formate transmembrane transporter activity
KQ252_10220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KQ252_10230	COG2983	Belongs to the UPF0260 family
KQ252_10250	COG1194	a g-specific adenine glycosylase
KQ252_10265	COG2818	Glycosylase
KQ252_10270	COG1064	alcohol dehydrogenase
KQ252_10275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KQ252_10290	COG0583	DNA-binding transcription factor activity
KQ252_10295	COG0656	L-ascorbic acid biosynthetic process
KQ252_10300	COG2814	Major facilitator Superfamily
KQ252_10335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KQ252_10350	COG2233	PERMEase
KQ252_10380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KQ252_10390	COG0733	neurotransmitter:sodium symporter activity
KQ252_10435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KQ252_10440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KQ252_10445	COG0596	Alpha beta hydrolase
KQ252_10470	COG0488	(ABC) transporter
KQ252_10475	COG0586	Pfam SNARE associated Golgi protein
KQ252_10485	COG0187	DNA topoisomerase II activity
KQ252_10495	COG0592	DNA-directed DNA polymerase activity
KQ252_10525	COG0706	membrane insertase activity
KQ252_10540	COG1230	cation diffusion facilitator family transporter
KQ252_10545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KQ252_10560	COG0402	S-adenosylhomocysteine deaminase activity
KQ252_10570	COG0754	glutathionylspermidine amidase activity
KQ252_10585	COG0861	Integral membrane protein TerC family
KQ252_10590	COG0671	phosphoesterase, PA-phosphatase related
KQ252_10600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KQ252_10615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KQ252_10620	COG2951	lytic endotransglycosylase activity
KQ252_10670	COG0657	acetylesterase activity
KQ252_10675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KQ252_10715	COG1047	Peptidyl-prolyl cis-trans
KQ252_10725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KQ252_10730	COG0196	riboflavin kinase activity
KQ252_10740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KQ252_10745	COG1309	transcriptional regulator
KQ252_10750	COG1116	anion transmembrane transporter activity
KQ252_10755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KQ252_10760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KQ252_10765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KQ252_10770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KQ252_10790	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_10795	COG0546	phosphoglycolate phosphatase activity
KQ252_10810	COG1309	transcriptional regulator
KQ252_10855	COG3023	N-Acetylmuramoyl-L-alanine amidase
KQ252_10860	COG0728	peptidoglycan biosynthetic process
KQ252_10885	COG1596	polysaccharide export
KQ252_10890	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KQ252_10910	COG0438	transferase activity, transferring glycosyl groups
KQ252_10915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KQ252_10925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KQ252_10935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KQ252_10950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KQ252_10955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KQ252_10965	COG2186	Transcriptional regulator
KQ252_10975	COG0277	FAD linked oxidase domain protein
KQ252_10980	COG1448	Aminotransferase
KQ252_10990	COG1802	Transcriptional regulator
KQ252_11005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KQ252_11025	COG1051	belongs to the nudix hydrolase family
KQ252_11055	COG0564	pseudouridine synthase activity
KQ252_11095	COG0251	oxidation-reduction process
KQ252_11100	COG1113	amino acid transport
KQ252_11105	COG1113	amino acid transport
KQ252_11125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KQ252_11130	COG1960	acyl-CoA dehydrogenase activity
KQ252_11135	COG1024	Enoyl-CoA hydratase
KQ252_11140	COG1024	Enoyl-CoA hydratase
KQ252_11145	COG0477	Major facilitator Superfamily
KQ252_11150	COG3916	Acyl-homoserine-lactone synthase
KQ252_11165	COG2197	response regulator
KQ252_11170	COG0318	PFAM AMP-dependent synthetase and ligase
KQ252_11175	COG1960	acyl-CoA dehydrogenase activity
KQ252_11180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KQ252_11180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KQ252_11180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KQ252_11180	COG3321	synthase
KQ252_11215	COG0271	Belongs to the BolA IbaG family
KQ252_11225	COG1192	Involved in chromosome partitioning
KQ252_11240	COG0586	Pfam SNARE associated Golgi protein
KQ252_11245	COG2259	Doxx family
KQ252_11250	COG4399	Belongs to the UPF0754 family
KQ252_11255	COG0519	Catalyzes the synthesis of GMP from XMP
KQ252_11255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KQ252_11300	COG0281	malic enzyme
KQ252_11305	COG2837	iron assimilation
KQ252_11310	COG1280	lysine exporter protein (LysE YggA)
KQ252_11315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KQ252_11320	COG1121	(ABC) transporter
KQ252_11385	COG0386	Belongs to the glutathione peroxidase family
KQ252_11400	COG1309	transcriptional regulator
KQ252_11405	COG0697	spore germination
KQ252_11415	COG0758	DNA mediated transformation
KQ252_11435	COG4771	TonB-dependent receptor
KQ252_11450	COG1309	transcriptional regulator
KQ252_11485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KQ252_11495	COG0655	NAD(P)H dehydrogenase (quinone) activity
KQ252_11530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KQ252_11540	COG0477	Major facilitator Superfamily
KQ252_11550	COG1253	flavin adenine dinucleotide binding
KQ252_11560	COG2860	membrane
KQ252_11565	COG0477	Major facilitator Superfamily
KQ252_11575	COG0318	PFAM AMP-dependent synthetase and ligase
KQ252_11590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KQ252_11610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KQ252_11620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KQ252_11625	COG0606	chelatase, subunit chli
KQ252_11655	COG3328	transposase activity
KQ252_11670	COG0589	response to stress
KQ252_11675	COG0659	secondary active sulfate transmembrane transporter activity
KQ252_11685	COG0606	chelatase, subunit chli
KQ252_11695	COG0347	Belongs to the P(II) protein family
KQ252_11700	COG0004	ammonium transporteR
KQ252_11710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KQ252_11710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KQ252_11750	COG0795	lipopolysaccharide-transporting ATPase activity
KQ252_11755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KQ252_11760	COG0793	Belongs to the peptidase S41A family
KQ252_11775	COG2197	response regulator
KQ252_11785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KQ252_11795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KQ252_11800	COG4974	Belongs to the 'phage' integrase family
KQ252_11825	COG0772	Belongs to the SEDS family
KQ252_11830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KQ252_11835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KQ252_11840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KQ252_11865	COG0697	spore germination
KQ252_11870	COG1538	Outer membrane efflux protein
KQ252_11890	COG3275	phosphorelay sensor kinase activity
KQ252_11900	COG0181	hydroxymethylbilane synthase activity
KQ252_11945	COG1716	ATPase activity
KQ252_11950	COG0546	phosphoglycolate phosphatase activity
KQ252_12050	COG2056	Na+-H+ antiporter family
KQ252_12065	COG0326	Molecular chaperone. Has ATPase activity
KQ252_12080	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KQ252_12150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KQ252_12155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KQ252_12155	COG2169	Transcriptional regulator
KQ252_12185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KQ252_12195	COG0497	DNA recombination
KQ252_12210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KQ252_12220	COG0237	dephospho-CoA kinase activity
KQ252_12270	COG0195	Participates in both transcription termination and antitermination
KQ252_12285	COG1320	monovalent cation:proton antiporter activity
KQ252_12290	COG2212	antiporter activity
KQ252_12295	COG1863	multisubunit Na H antiporter MnhE subunit
KQ252_12300	COG0651	ATP synthesis coupled electron transport
KQ252_12305	COG1006	Multisubunit Na H antiporter MnhC subunit
KQ252_12310	COG2111	Na H antiporter
KQ252_12310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KQ252_12325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KQ252_12345	COG2226	methyltransferase
KQ252_12365	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KQ252_12370	COG1074	ATP-dependent DNA helicase activity
KQ252_12375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KQ252_12380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KQ252_12395	COG0598	Magnesium transport protein CorA
KQ252_12400	COG0789	Transcriptional regulator
KQ252_12405	COG0484	heat shock protein binding
KQ252_12420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KQ252_12420	COG0475	glutathione-regulated potassium exporter activity
KQ252_12425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KQ252_12445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KQ252_12455	COG4535	Mg2 and Co2 transporter CorC
KQ252_12460	COG0425	Belongs to the sulfur carrier protein TusA family
KQ252_12470	COG0644	oxidoreductase
KQ252_12470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KQ252_12480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KQ252_12495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KQ252_12500	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KQ252_12510	COG0493	'glutamate synthase
KQ252_12510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KQ252_12535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KQ252_12550	COG0534	Mate efflux family protein
KQ252_12560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KQ252_12565	COG4221	oxidoreductase activity
KQ252_12570	COG0583	DNA-binding transcription factor activity
KQ252_12585	COG0318	PFAM AMP-dependent synthetase and ligase
KQ252_12590	COG1530	ribonuclease E activity
KQ252_12600	COG0546	phosphoglycolate phosphatase activity
KQ252_12605	COG2378	regulation of single-species biofilm formation
KQ252_12610	COG0625	glutathione transferase activity
KQ252_12620	COG0583	DNA-binding transcription factor activity
KQ252_12685	COG0473	3-isopropylmalate dehydrogenase activity
KQ252_12740	COG1301	dicarboxylic acid transport
KQ252_12750	COG1560	Kdo2-lipid A biosynthetic process
KQ252_12755	COG1280	lysine exporter protein (LysE YggA)
KQ252_12760	COG0488	(ABC) transporter
KQ252_12765	COG2900	Belongs to the SlyX family
KQ252_12775	COG1733	regulation of RNA biosynthetic process
KQ252_12800	COG0210	DNA helicase
KQ252_12805	COG0724	RNA recognition motif
KQ252_12825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KQ252_12825	COG4651	solute:proton antiporter activity
KQ252_12850	COG0788	formyltetrahydrofolate deformylase activity
KQ252_12950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KQ252_12950	COG2813	Specifically methylates the guanine in position
KQ252_12960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KQ252_12970	COG4774	siderophore transport
KQ252_12980	COG0740	serine-type endopeptidase activity
KQ252_13000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KQ252_13000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KQ252_13005	COG0280	phosphate acetyltransferase
KQ252_13005	COG0857	belongs to the CobB CobQ family
KQ252_13010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KQ252_13020	COG0800	Aldolase
KQ252_13030	COG3265	gluconokinase activity
KQ252_13035	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_13045	COG2267	carboxylic ester hydrolase activity
KQ252_13060	COG0793	Belongs to the peptidase S41A family
KQ252_13095	COG1426	Protein conserved in bacteria
KQ252_13135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KQ252_13145	COG1162	GTPase activity
KQ252_13150	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KQ252_13165	COG1538	Outer membrane efflux protein
KQ252_13170	COG0577	efflux transmembrane transporter activity
KQ252_13170	COG1136	(ABC) transporter
KQ252_13175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KQ252_13200	COG0028	Belongs to the TPP enzyme family
KQ252_13205	COG0440	acetolactate synthase activity
KQ252_13235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KQ252_13250	COG0084	hydrolase, TatD family'
KQ252_13265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KQ252_13275	COG0583	DNA-binding transcription factor activity
KQ252_13285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KQ252_13290	COG2814	Major facilitator Superfamily
KQ252_13300	COG0697	spore germination
KQ252_13330	COG3622	Belongs to the hyi family
KQ252_13335	COG2084	Dehydrogenase
KQ252_13340	COG1024	Enoyl-CoA hydratase
KQ252_13345	COG2205	protein histidine kinase activity
KQ252_13345	COG5002	protein histidine kinase activity
KQ252_13345	COG0784	Response regulator, receiver
KQ252_13365	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KQ252_13370	COG4221	oxidoreductase activity
KQ252_13375	COG3956	TIGRFAM MazG family protein
KQ252_13380	COG1555	photosystem II stabilization
KQ252_13385	COG0617	tRNA 3'-terminal CCA addition
KQ252_13390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KQ252_13410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KQ252_13415	COG3028	Belongs to the UPF0307 family
KQ252_13420	COG0318	PFAM AMP-dependent synthetase and ligase
KQ252_13435	COG0625	glutathione transferase activity
KQ252_13440	COG1238	metal cluster binding
KQ252_13480	COG0072	phenylalanine-tRNA ligase activity
KQ252_13510	COG0248	Ppx GppA phosphatase
KQ252_13520	COG0037	tRNA processing
KQ252_13560	COG1764	response to oxidative stress
KQ252_13565	COG1846	Transcriptional regulator
KQ252_13575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KQ252_13635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KQ252_13640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KQ252_13645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KQ252_13705	COG1214	PFAM Peptidase M22, glycoprotease
KQ252_13720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KQ252_13730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KQ252_13735	COG0561	phosphatase activity
KQ252_13745	COG2132	Multicopper oxidase
KQ252_13750	COG3667	copper resistance
KQ252_13765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KQ252_13770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KQ252_13775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KQ252_13805	COG1063	alcohol dehydrogenase
KQ252_13810	COG0583	DNA-binding transcription factor activity
KQ252_13815	COG1960	acyl-CoA dehydrogenase activity
KQ252_13820	COG2814	Major facilitator Superfamily
KQ252_13825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KQ252_13835	COG1053	succinate dehydrogenase
KQ252_13840	COG0583	DNA-binding transcription factor activity
KQ252_13855	COG0583	DNA-binding transcription factor activity
KQ252_13895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KQ252_13945	COG4993	Dehydrogenase
KQ252_14010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KQ252_14030	COG0745	RESPONSE REGULATOR receiver
KQ252_14070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KQ252_14100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KQ252_14105	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KQ252_14130	COG0583	DNA-binding transcription factor activity
KQ252_14150	COG0668	transmembrane transport
KQ252_14160	COG2081	HI0933 family
KQ252_14165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KQ252_14195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KQ252_14195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KQ252_14205	COG0489	protein tyrosine kinase activity
KQ252_14260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KQ252_14270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KQ252_14285	COG0730	response to heat
KQ252_14295	COG1196	nuclear chromosome segregation
KQ252_14315	COG2223	nitrite transmembrane transporter activity
KQ252_14320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KQ252_14325	COG1877	trehalose-phosphatase activity
KQ252_14330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KQ252_14330	COG2226	methyltransferase
KQ252_14330	COG0596	Alpha beta hydrolase
KQ252_14345	COG4106	trans-aconitate 2-methyltransferase activity
KQ252_14360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KQ252_14365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KQ252_14370	COG0009	L-threonylcarbamoyladenylate synthase
KQ252_14375	COG3101	peptidyl-lysine hydroxylation
KQ252_14380	COG1399	metal-binding, possibly nucleic acid-binding protein
KQ252_14405	COG1652	LysM domain
KQ252_14410	COG0351	phosphomethylpyrimidine kinase
KQ252_14410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KQ252_14410	COG0352	thiamine-phosphate diphosphorylase activity
KQ252_14420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KQ252_14450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KQ252_14480	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KQ252_14495	COG0358	DNA primase activity
KQ252_14505	COG0564	pseudouridine synthase activity
KQ252_14530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KQ252_14550	COG0583	DNA-binding transcription factor activity
KQ252_14555	COG0473	3-isopropylmalate dehydrogenase activity
KQ252_14565	COG0657	acetylesterase activity
KQ252_14575	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_14595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KQ252_14595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KQ252_14610	COG1981	membrane
KQ252_14655	COG0456	acetyltransferase
KQ252_14665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KQ252_14670	COG0492	ferredoxin-NADP+ reductase activity
KQ252_14675	COG1674	ftsk spoiiie
KQ252_14675	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KQ252_14680	COG1280	lysine exporter protein (LysE YggA)
KQ252_14695	COG2894	cell division
KQ252_14710	COG0204	Acyl-transferase
KQ252_14715	COG2885	chlorophyll binding
KQ252_14720	COG0210	DNA helicase
KQ252_14730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KQ252_14745	COG0121	glutamine amidotransferase
KQ252_14765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KQ252_14770	COG0735	belongs to the Fur family
KQ252_14795	COG0420	3'-5' exonuclease activity
KQ252_14815	COG1090	epimerase
KQ252_14830	COG2050	protein possibly involved in aromatic compounds catabolism
KQ252_14840	COG2814	Major facilitator Superfamily
KQ252_14845	COG0405	Gamma-glutamyltransferase
KQ252_14855	COG0582	viral genome integration into host DNA
KQ252_14970	COG0477	Major facilitator Superfamily
KQ252_14975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KQ252_14985	COG1595	DNA-templated transcription, initiation
KQ252_15040	COG0531	amino acid
KQ252_15045	COG2040	homocysteine
KQ252_15070	COG1309	transcriptional regulator
KQ252_15075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KQ252_15080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KQ252_15090	COG1607	acyl-coa hydrolase
KQ252_15100	COG0523	cobalamin synthesis protein
KQ252_15110	COG4681	YaeQ
KQ252_15120	COG1649	PFAM Uncharacterised BCR, COG1649
KQ252_15120	COG0726	polysaccharide deacetylase
KQ252_15125	COG1215	transferase activity, transferring glycosyl groups
KQ252_15135	COG1024	Enoyl-CoA hydratase
KQ252_15150	COG1414	Transcriptional regulator
KQ252_15170	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_15185	COG2271	Major facilitator Superfamily
KQ252_15195	COG2267	carboxylic ester hydrolase activity
KQ252_15200	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_15215	COG0028	Belongs to the TPP enzyme family
KQ252_15225	COG0477	Major facilitator Superfamily
KQ252_15230	COG0242	peptide deformylase activity
KQ252_15235	COG2066	Belongs to the glutaminase family
KQ252_15240	COG2207	Transcriptional regulator
KQ252_15245	COG2223	nitrite transmembrane transporter activity
KQ252_15260	COG0583	DNA-binding transcription factor activity
KQ252_15265	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_15270	COG2271	Major facilitator Superfamily
KQ252_15275	COG3959	Transketolase, thiamine diphosphate binding domain
KQ252_15280	COG3958	Transketolase
KQ252_15290	COG0306	phosphate transporter
KQ252_15310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KQ252_15355	COG4181	ATPase activity
KQ252_15360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KQ252_15390	COG0583	DNA-binding transcription factor activity
KQ252_15400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KQ252_15405	COG1773	rubredoxin
KQ252_15460	COG1253	flavin adenine dinucleotide binding
KQ252_15500	COG0804	urea catabolic process
KQ252_15510	COG0830	nickel cation binding
KQ252_15525	COG0742	ribosomal rna small subunit methyltransferase
KQ252_15530	COG0768	penicillin binding
KQ252_15555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KQ252_15560	COG2878	Part of a membrane complex involved in electron transport
KQ252_15565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KQ252_15575	COG3384	dioxygenase
KQ252_15600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KQ252_15930	COG0739	heme binding
KQ252_15975	COG3179	chitinase
KQ252_15990	COG3617	BRO family, N-terminal domain
KQ252_16035	COG0006	proline dipeptidase activity
KQ252_16040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KQ252_16045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KQ252_16065	COG1279	arginine transmembrane transporter activity
KQ252_16070	COG0583	DNA-binding transcription factor activity
KQ252_16110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KQ252_16115	COG0741	lytic transglycosylase activity
KQ252_16115	COG1388	LysM domain
KQ252_16115	COG0741	lytic transglycosylase activity
KQ252_16115	COG1388	LysM domain
KQ252_16125	COG4174	ABC transporter (Permease)
KQ252_16130	COG4239	(ABC) transporter, permease
KQ252_16135	COG4172	Belongs to the ABC transporter superfamily
KQ252_16155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KQ252_16165	COG3706	GGDEF domain
KQ252_16165	COG4251	negative regulation of phosphorylation
KQ252_16165	COG5001	Diguanylate cyclase
KQ252_16165	COG2203	Gaf domain
KQ252_16175	COG1902	pentaerythritol trinitrate reductase activity
KQ252_16175	COG0446	pyridine nucleotide-disulphide oxidoreductase
KQ252_16190	COG4269	membrane
KQ252_16215	COG3209	COG3209 Rhs family protein
KQ252_16285	COG1113	amino acid transport
KQ252_16295	COG0531	amino acid
KQ252_16315	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_16335	COG1113	amino acid transport
KQ252_16355	COG0697	spore germination
KQ252_16360	COG2721	sulfolactate sulfo-lyase activity
KQ252_16365	COG2271	Major facilitator Superfamily
KQ252_16370	COG4948	Mandelate Racemase Muconate Lactonizing
KQ252_16380	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_16385	COG2186	Transcriptional regulator
KQ252_16410	COG1960	acyl-CoA dehydrogenase activity
KQ252_16420	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_16425	COG1024	Enoyl-CoA hydratase
KQ252_16430	COG2814	Major facilitator Superfamily
KQ252_16445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KQ252_16485	COG2207	Transcriptional regulator
KQ252_16490	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KQ252_16495	COG2072	flavoprotein involved in K transport
KQ252_16500	COG0300	oxidoreductase activity
KQ252_16510	COG1309	transcriptional regulator
KQ252_16515	COG1741	Belongs to the pirin family
KQ252_16530	COG2072	flavoprotein involved in K transport
KQ252_16540	COG2252	PERMEase
KQ252_16545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KQ252_16550	COG3038	cytochrome b561
KQ252_16560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KQ252_16570	COG0527	aspartate kinase activity
KQ252_16580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KQ252_16595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KQ252_16610	COG0667	Aldo Keto reductase
KQ252_16625	COG1765	OsmC-like protein
KQ252_16640	COG0542	response to heat
KQ252_16675	COG2885	chlorophyll binding
KQ252_16685	COG0625	glutathione transferase activity
KQ252_16690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KQ252_16710	COG3634	alkyl hydroperoxide reductase activity
KQ252_16720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KQ252_16730	COG0450	alkyl hydroperoxide reductase
KQ252_16735	COG1643	Atp-dependent helicase
KQ252_16750	COG2814	Major facilitator Superfamily
KQ252_16755	COG3135	benzoate transporter
KQ252_16760	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_16765	COG0543	2 iron, 2 sulfur cluster binding
KQ252_16765	COG0633	Ferredoxin
KQ252_16770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KQ252_16775	COG4638	Rieske (2fe-2S)
KQ252_16780	COG0583	DNA-binding transcription factor activity
KQ252_16830	COG1570	exodeoxyribonuclease VII activity
KQ252_16860	COG1280	lysine exporter protein (LysE YggA)
KQ252_16865	COG1278	Cold shock
KQ252_16900	COG2814	Major facilitator Superfamily
KQ252_16970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KQ252_16980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KQ252_16985	COG1137	ATPase activity
KQ252_16990	COG1538	Outer membrane efflux protein
KQ252_17020	COG4122	O-methyltransferase activity
KQ252_17030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KQ252_17045	COG1522	sequence-specific DNA binding
KQ252_17050	COG5006	permease, DMT superfamily
KQ252_17060	COG1560	Kdo2-lipid A biosynthetic process
KQ252_17075	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_17105	COG1250	3-hydroxyacyl-CoA dehydrogenase
KQ252_17145	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_17165	COG3209	COG3209 Rhs family protein
KQ252_17190	COG0583	DNA-binding transcription factor activity
KQ252_17195	COG1914	H( )-stimulated, divalent metal cation uptake system
KQ252_17215	COG4770	biotin carboxylase activity
KQ252_17220	COG0038	chloride channel
KQ252_17230	COG1309	transcriptional regulator
KQ252_17240	COG1063	alcohol dehydrogenase
KQ252_17255	COG0439	Biotin carboxylase
KQ252_17260	COG2249	NAD(P)H dehydrogenase (quinone) activity
KQ252_17265	COG1733	regulation of RNA biosynthetic process
KQ252_17280	COG0864	Transcriptional regulator
KQ252_17290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KQ252_17295	COG1116	anion transmembrane transporter activity
KQ252_17410	COG0590	tRNA wobble adenosine to inosine editing
KQ252_17415	COG2807	transmembrane transport
KQ252_17430	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KQ252_17440	COG0789	Transcriptional regulator
KQ252_17450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KQ252_17470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KQ252_17495	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_17500	COG0531	amino acid
KQ252_17505	COG1760	l-serine dehydratase
KQ252_17510	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_17510	COG2030	dehydratase
KQ252_17515	COG3396	Phenylacetate-CoA oxygenase
KQ252_17520	COG3460	Phenylacetate-CoA oxygenase
KQ252_17525	COG3396	Phenylacetate-CoA oxygenase
KQ252_17530	COG2151	metal-sulfur cluster biosynthetic enzyme
KQ252_17535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KQ252_17540	COG1024	Enoyl-CoA hydratase
KQ252_17545	COG1024	Enoyl-CoA hydratase
KQ252_17550	COG1250	3-hydroxyacyl-CoA dehydrogenase
KQ252_17555	COG0183	Belongs to the thiolase family
KQ252_17560	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KQ252_17565	COG3327	negative regulation of DNA-templated transcription, initiation
KQ252_17575	COG2050	protein possibly involved in aromatic compounds catabolism
KQ252_17585	COG0406	alpha-ribazole phosphatase activity
KQ252_17615	COG0753	catalase activity
KQ252_17620	COG3038	cytochrome b561
KQ252_17640	COG2267	carboxylic ester hydrolase activity
KQ252_17645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KQ252_17650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KQ252_17655	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_17665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KQ252_17675	COG1012	belongs to the aldehyde dehydrogenase family
KQ252_17680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KQ252_17685	COG0583	DNA-binding transcription factor activity
KQ252_17695	COG1414	Transcriptional regulator
KQ252_17700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KQ252_17710	COG1840	ABC-type Fe3 transport system, periplasmic component
KQ252_17715	COG3842	ATPase activity
KQ252_17730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KQ252_17735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KQ252_17740	COG2814	Major facilitator Superfamily
KQ252_17745	COG1960	acyl-CoA dehydrogenase activity
KQ252_17750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KQ252_17760	COG1024	Enoyl-CoA hydratase
KQ252_17775	COG2192	nodulation
KQ252_17780	COG1280	lysine exporter protein (LysE YggA)
KQ252_17795	COG0183	Belongs to the thiolase family
KQ252_17800	COG1250	3-hydroxyacyl-CoA dehydrogenase
KQ252_17805	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_17810	COG1024	Enoyl-CoA hydratase
KQ252_17815	COG1960	acyl-CoA dehydrogenase activity
KQ252_17820	COG2814	Major facilitator Superfamily
KQ252_17825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KQ252_17830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KQ252_17840	COG2814	Major facilitator Superfamily
KQ252_17850	COG1960	acyl-CoA dehydrogenase activity
KQ252_17865	COG0583	DNA-binding transcription factor activity
KQ252_17875	COG4770	biotin carboxylase activity
KQ252_17880	COG1024	Enoyl-CoA hydratase
KQ252_17885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KQ252_17890	COG1960	acyl-CoA dehydrogenase activity
KQ252_17895	COG1309	transcriptional regulator
KQ252_17900	COG0318	PFAM AMP-dependent synthetase and ligase
KQ252_17920	COG0583	DNA-binding transcription factor activity
KQ252_17970	COG1028	Short-chain dehydrogenase reductase Sdr
KQ252_17990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KQ252_18010	COG0784	Response regulator, receiver
KQ252_18010	COG2205	protein histidine kinase activity
KQ252_18030	COG0765	amino acid transport
KQ252_18035	COG0765	amino acid transport
KQ252_18045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KQ252_18050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KQ252_18065	COG1280	lysine exporter protein (LysE YggA)
KQ252_18070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KQ252_18075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KQ252_18085	COG1045	serine acetyltransferase
KQ252_18100	COG0583	DNA-binding transcription factor activity
KQ252_18105	COG0625	glutathione transferase activity
KQ252_18110	COG0625	glutathione transferase activity
KQ252_18115	COG0583	DNA-binding transcription factor activity
KQ252_18125	COG1346	cytolysis
KQ252_18145	COG2814	Major facilitator Superfamily
KQ252_18155	COG0583	DNA-binding transcription factor activity
KQ252_18165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KQ252_18170	COG3052	prosthetic group binding
KQ252_18190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KQ252_18210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KQ252_18220	COG1294	oxidase, subunit
KQ252_18225	COG1271	oxidase subunit
KQ252_18245	COG0477	Major facilitator Superfamily
KQ252_18255	COG4521	taurine ABC transporter
KQ252_18260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KQ252_18265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KQ252_18270	COG2175	clavaminate synthase activity
KQ252_18280	COG1953	Uracil, thiamine, allantoin
KQ252_18290	COG0583	DNA-binding transcription factor activity
KQ252_18300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KQ252_18315	COG0640	Transcriptional regulator
KQ252_18320	COG0798	PFAM Bile acid sodium symporter
KQ252_18325	COG0583	DNA-binding transcription factor activity
KQ252_18340	COG3634	alkyl hydroperoxide reductase activity
KQ252_18375	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_18430	COG1525	nuclease
KQ252_18485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KQ252_18515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KQ252_18525	COG4372	Transposase
KQ252_18575	COG1475	DNA binding
KQ252_18590	COG3853	Toxic anion resistance protein (TelA)
KQ252_18680	COG0484	heat shock protein binding
KQ252_18765	COG0741	lytic transglycosylase activity
KQ252_18800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KQ252_18880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KQ252_18890	COG2826	transposase and inactivated derivatives, IS30 family
KQ252_18925	COG4683	PFAM Phage derived protein Gp49-like (DUF891)