locus-tag	class	description
HBM80_00055	COG1525	nuclease
HBM80_00115	COG1475	DNA binding
HBM80_00130	COG3853	Toxic anion resistance protein (TelA)
HBM80_00215	COG0484	heat shock protein binding
HBM80_00280	COG2826	transposase and inactivated derivatives, IS30 family
HBM80_00290	COG2826	transposase and inactivated derivatives, IS30 family
HBM80_00315	COG0741	lytic transglycosylase activity
HBM80_00350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM80_00435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBM80_00525	COG0589	response to stress
HBM80_00540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM80_00590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM80_00625	COG0589	response to stress
HBM80_00630	COG0659	secondary active sulfate transmembrane transporter activity
HBM80_00690	COG0606	chelatase, subunit chli
HBM80_00700	COG0347	Belongs to the P(II) protein family
HBM80_00705	COG0004	ammonium transporteR
HBM80_00715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBM80_00715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBM80_00755	COG0795	lipopolysaccharide-transporting ATPase activity
HBM80_00760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HBM80_00765	COG0793	Belongs to the peptidase S41A family
HBM80_00780	COG2197	response regulator
HBM80_00790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBM80_00800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM80_00805	COG4974	Belongs to the 'phage' integrase family
HBM80_00830	COG0772	Belongs to the SEDS family
HBM80_00835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBM80_00840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HBM80_00845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBM80_00870	COG0697	spore germination
HBM80_00875	COG1538	Outer membrane efflux protein
HBM80_00895	COG3275	phosphorelay sensor kinase activity
HBM80_00905	COG0181	hydroxymethylbilane synthase activity
HBM80_00950	COG1716	ATPase activity
HBM80_00955	COG0546	phosphoglycolate phosphatase activity
HBM80_01050	COG0596	Alpha beta hydrolase
HBM80_01055	COG2056	Na+-H+ antiporter family
HBM80_01070	COG0326	Molecular chaperone. Has ATPase activity
HBM80_01085	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HBM80_01150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBM80_01155	COG2169	Transcriptional regulator
HBM80_01155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBM80_01185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HBM80_01195	COG0497	DNA recombination
HBM80_01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBM80_01220	COG0237	dephospho-CoA kinase activity
HBM80_01270	COG0195	Participates in both transcription termination and antitermination
HBM80_01290	COG2212	antiporter activity
HBM80_01300	COG0651	ATP synthesis coupled electron transport
HBM80_01305	COG1006	Multisubunit Na H antiporter MnhC subunit
HBM80_01310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBM80_01310	COG2111	Na H antiporter
HBM80_01325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HBM80_01330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM80_01345	COG2226	methyltransferase
HBM80_01365	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HBM80_01370	COG1074	ATP-dependent DNA helicase activity
HBM80_01375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBM80_01395	COG0598	Magnesium transport protein CorA
HBM80_01400	COG0789	Transcriptional regulator
HBM80_01405	COG0484	heat shock protein binding
HBM80_01415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HBM80_01420	COG0475	glutathione-regulated potassium exporter activity
HBM80_01420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM80_01425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBM80_01445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM80_01455	COG4535	Mg2 and Co2 transporter CorC
HBM80_01460	COG0425	Belongs to the sulfur carrier protein TusA family
HBM80_01465	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HBM80_01465	COG0644	oxidoreductase
HBM80_01475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBM80_01490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM80_01495	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HBM80_01535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBM80_01550	COG0534	Mate efflux family protein
HBM80_01560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBM80_01565	COG4221	oxidoreductase activity
HBM80_01570	COG0583	DNA-binding transcription factor activity
HBM80_01585	COG0318	PFAM AMP-dependent synthetase and ligase
HBM80_01590	COG1530	ribonuclease E activity
HBM80_01605	COG0546	phosphoglycolate phosphatase activity
HBM80_01610	COG2378	regulation of single-species biofilm formation
HBM80_01615	COG0625	glutathione transferase activity
HBM80_01625	COG0583	DNA-binding transcription factor activity
HBM80_01690	COG0473	3-isopropylmalate dehydrogenase activity
HBM80_01745	COG1301	dicarboxylic acid transport
HBM80_01755	COG1560	Kdo2-lipid A biosynthetic process
HBM80_01760	COG1280	lysine exporter protein (LysE YggA)
HBM80_01770	COG2900	Belongs to the SlyX family
HBM80_01780	COG1733	regulation of RNA biosynthetic process
HBM80_01805	COG0210	DNA helicase
HBM80_01810	COG0724	RNA recognition motif
HBM80_01830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM80_01830	COG4651	solute:proton antiporter activity
HBM80_01855	COG0788	formyltetrahydrofolate deformylase activity
HBM80_01955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM80_01955	COG2813	Specifically methylates the guanine in position
HBM80_01965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HBM80_01975	COG4774	siderophore transport
HBM80_01985	COG0740	serine-type endopeptidase activity
HBM80_02005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HBM80_02005	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HBM80_02010	COG0857	belongs to the CobB CobQ family
HBM80_02010	COG0280	phosphate acetyltransferase
HBM80_02015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HBM80_02030	COG0800	Aldolase
HBM80_02040	COG3265	gluconokinase activity
HBM80_02045	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_02055	COG2267	carboxylic ester hydrolase activity
HBM80_02070	COG0793	Belongs to the peptidase S41A family
HBM80_02105	COG1426	Protein conserved in bacteria
HBM80_02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBM80_02160	COG0318	PFAM AMP-dependent synthetase and ligase
HBM80_02175	COG2986	histidine ammonia-lyase
HBM80_02215	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_02220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBM80_02240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBM80_02250	COG1162	GTPase activity
HBM80_02255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HBM80_02270	COG1538	Outer membrane efflux protein
HBM80_02275	COG1136	(ABC) transporter
HBM80_02275	COG0577	efflux transmembrane transporter activity
HBM80_02280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM80_02305	COG0028	Belongs to the TPP enzyme family
HBM80_02310	COG0440	acetolactate synthase activity
HBM80_02340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HBM80_02355	COG0084	hydrolase, TatD family'
HBM80_02370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HBM80_02380	COG0583	DNA-binding transcription factor activity
HBM80_02390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBM80_02395	COG2814	Major facilitator Superfamily
HBM80_02405	COG0697	spore germination
HBM80_02435	COG3622	Belongs to the hyi family
HBM80_02440	COG2084	Dehydrogenase
HBM80_02445	COG1024	Enoyl-CoA hydratase
HBM80_02450	COG0784	Response regulator, receiver
HBM80_02450	COG5002	protein histidine kinase activity
HBM80_02450	COG2205	protein histidine kinase activity
HBM80_02470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBM80_02495	COG1555	photosystem II stabilization
HBM80_02500	COG0617	tRNA 3'-terminal CCA addition
HBM80_02505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBM80_02525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBM80_02530	COG3028	Belongs to the UPF0307 family
HBM80_02535	COG0318	PFAM AMP-dependent synthetase and ligase
HBM80_02550	COG0625	glutathione transferase activity
HBM80_02555	COG1238	metal cluster binding
HBM80_02595	COG0072	phenylalanine-tRNA ligase activity
HBM80_02625	COG0248	Ppx GppA phosphatase
HBM80_02635	COG0037	tRNA processing
HBM80_02685	COG1764	response to oxidative stress
HBM80_02690	COG1846	Transcriptional regulator
HBM80_02700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBM80_02760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HBM80_02765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBM80_02770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBM80_02780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBM80_02830	COG1214	PFAM Peptidase M22, glycoprotease
HBM80_02855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBM80_02860	COG0561	phosphatase activity
HBM80_02870	COG2132	Multicopper oxidase
HBM80_02875	COG3667	copper resistance
HBM80_02890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBM80_02895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HBM80_02900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HBM80_02930	COG1063	alcohol dehydrogenase
HBM80_02935	COG0583	DNA-binding transcription factor activity
HBM80_02940	COG1960	acyl-CoA dehydrogenase activity
HBM80_02945	COG2814	Major facilitator Superfamily
HBM80_02950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HBM80_02960	COG1053	succinate dehydrogenase
HBM80_02965	COG0583	DNA-binding transcription factor activity
HBM80_02980	COG0583	DNA-binding transcription factor activity
HBM80_02990	COG1473	amidohydrolase
HBM80_03010	COG0583	DNA-binding transcription factor activity
HBM80_03025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM80_03045	COG0384	phenazine biosynthesis protein PhzF
HBM80_03065	COG4993	Dehydrogenase
HBM80_03135	COG2205	protein histidine kinase activity
HBM80_03145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBM80_03165	COG0745	RESPONSE REGULATOR receiver
HBM80_03170	COG2205	protein histidine kinase activity
HBM80_03205	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HBM80_03235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBM80_03240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBM80_03260	COG0583	DNA-binding transcription factor activity
HBM80_03280	COG0668	transmembrane transport
HBM80_03290	COG2081	HI0933 family
HBM80_03295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HBM80_03325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM80_03325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM80_03335	COG0489	protein tyrosine kinase activity
HBM80_03385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBM80_03395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBM80_03410	COG0730	response to heat
HBM80_03420	COG1196	nuclear chromosome segregation
HBM80_03440	COG2223	nitrite transmembrane transporter activity
HBM80_03445	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HBM80_03450	COG1877	trehalose-phosphatase activity
HBM80_03455	COG2226	methyltransferase
HBM80_03455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM80_03455	COG0596	Alpha beta hydrolase
HBM80_03470	COG4106	trans-aconitate 2-methyltransferase activity
HBM80_03485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HBM80_03490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HBM80_03495	COG0009	L-threonylcarbamoyladenylate synthase
HBM80_03500	COG3101	peptidyl-lysine hydroxylation
HBM80_03505	COG1399	metal-binding, possibly nucleic acid-binding protein
HBM80_03530	COG1652	LysM domain
HBM80_03535	COG0352	thiamine-phosphate diphosphorylase activity
HBM80_03535	COG0351	phosphomethylpyrimidine kinase
HBM80_03535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBM80_03545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBM80_03575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBM80_03605	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HBM80_03620	COG0358	DNA primase activity
HBM80_03630	COG0564	pseudouridine synthase activity
HBM80_03655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBM80_03675	COG0583	DNA-binding transcription factor activity
HBM80_03680	COG0473	3-isopropylmalate dehydrogenase activity
HBM80_03700	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_03720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBM80_03720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBM80_03780	COG0456	acetyltransferase
HBM80_03790	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HBM80_03795	COG0492	ferredoxin-NADP+ reductase activity
HBM80_03800	COG1674	ftsk spoiiie
HBM80_03800	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBM80_03805	COG1280	lysine exporter protein (LysE YggA)
HBM80_03830	COG2894	cell division
HBM80_03845	COG0204	Acyl-transferase
HBM80_03850	COG2885	chlorophyll binding
HBM80_03855	COG0210	DNA helicase
HBM80_03865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM80_03880	COG0121	glutamine amidotransferase
HBM80_03900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HBM80_03905	COG0735	belongs to the Fur family
HBM80_03930	COG0420	3'-5' exonuclease activity
HBM80_03950	COG1090	epimerase
HBM80_03965	COG2050	protein possibly involved in aromatic compounds catabolism
HBM80_03975	COG2814	Major facilitator Superfamily
HBM80_03980	COG0405	Gamma-glutamyltransferase
HBM80_04050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM80_04140	COG1484	DNA-dependent DNA replication
HBM80_04335	COG2026	Addiction module toxin, RelE StbE family
HBM80_04375	COG0592	DNA-directed DNA polymerase activity
HBM80_04470	COG0582	viral genome integration into host DNA
HBM80_04525	COG0629	single-stranded DNA binding
HBM80_04560	COG0084	hydrolase, TatD family'
HBM80_04580	COG0477	Major facilitator Superfamily
HBM80_04585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM80_04595	COG1595	DNA-templated transcription, initiation
HBM80_04650	COG0531	amino acid
HBM80_04655	COG2040	homocysteine
HBM80_04680	COG1309	transcriptional regulator
HBM80_04685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM80_04690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM80_04700	COG1607	acyl-coa hydrolase
HBM80_04710	COG0523	cobalamin synthesis protein
HBM80_04720	COG4681	YaeQ
HBM80_04730	COG0726	polysaccharide deacetylase
HBM80_04730	COG1649	PFAM Uncharacterised BCR, COG1649
HBM80_04735	COG1215	transferase activity, transferring glycosyl groups
HBM80_04745	COG1024	Enoyl-CoA hydratase
HBM80_04760	COG1414	Transcriptional regulator
HBM80_04780	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_04790	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM80_04795	COG2271	Major facilitator Superfamily
HBM80_04805	COG2267	carboxylic ester hydrolase activity
HBM80_04810	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_04825	COG0028	Belongs to the TPP enzyme family
HBM80_04835	COG0477	Major facilitator Superfamily
HBM80_04840	COG0242	peptide deformylase activity
HBM80_04845	COG2066	Belongs to the glutaminase family
HBM80_04850	COG2207	Transcriptional regulator
HBM80_04855	COG2223	nitrite transmembrane transporter activity
HBM80_04870	COG0583	DNA-binding transcription factor activity
HBM80_04875	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_04880	COG2271	Major facilitator Superfamily
HBM80_04885	COG3959	Transketolase, thiamine diphosphate binding domain
HBM80_04890	COG3958	Transketolase
HBM80_04900	COG0306	phosphate transporter
HBM80_04920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HBM80_04965	COG4181	ATPase activity
HBM80_04970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HBM80_04995	COG0583	DNA-binding transcription factor activity
HBM80_05005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM80_05010	COG1773	rubredoxin
HBM80_05065	COG2851	Citrate transporter
HBM80_05070	COG1253	flavin adenine dinucleotide binding
HBM80_05110	COG0804	urea catabolic process
HBM80_05120	COG0830	nickel cation binding
HBM80_05135	COG0742	ribosomal rna small subunit methyltransferase
HBM80_05140	COG0768	penicillin binding
HBM80_05165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBM80_05170	COG2878	Part of a membrane complex involved in electron transport
HBM80_05175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBM80_05185	COG3384	dioxygenase
HBM80_05210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HBM80_05465	COG0739	heme binding
HBM80_05510	COG2194	sulfuric ester hydrolase activity
HBM80_05545	COG0006	proline dipeptidase activity
HBM80_05550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM80_05555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM80_05575	COG1279	arginine transmembrane transporter activity
HBM80_05580	COG0583	DNA-binding transcription factor activity
HBM80_05620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM80_05625	COG0741	lytic transglycosylase activity
HBM80_05625	COG1388	LysM domain
HBM80_05625	COG0741	lytic transglycosylase activity
HBM80_05625	COG1388	LysM domain
HBM80_05635	COG4174	ABC transporter (Permease)
HBM80_05640	COG4239	(ABC) transporter, permease
HBM80_05645	COG4172	Belongs to the ABC transporter superfamily
HBM80_05665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM80_05675	COG3706	GGDEF domain
HBM80_05675	COG4251	negative regulation of phosphorylation
HBM80_05675	COG5001	Diguanylate cyclase
HBM80_05675	COG2203	Gaf domain
HBM80_05685	COG1902	pentaerythritol trinitrate reductase activity
HBM80_05685	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM80_05705	COG1309	transcriptional regulator
HBM80_05710	COG1741	Belongs to the pirin family
HBM80_05725	COG2072	flavoprotein involved in K transport
HBM80_05735	COG2252	PERMEase
HBM80_05740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HBM80_05745	COG3038	cytochrome b561
HBM80_05755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HBM80_05765	COG0527	aspartate kinase activity
HBM80_05775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HBM80_05785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HBM80_05800	COG0667	Aldo Keto reductase
HBM80_05815	COG1765	OsmC-like protein
HBM80_05830	COG0542	response to heat
HBM80_05865	COG2885	chlorophyll binding
HBM80_05875	COG0625	glutathione transferase activity
HBM80_05880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HBM80_05900	COG3634	alkyl hydroperoxide reductase activity
HBM80_05910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBM80_05920	COG0450	alkyl hydroperoxide reductase
HBM80_05925	COG1643	Atp-dependent helicase
HBM80_05940	COG2814	Major facilitator Superfamily
HBM80_05945	COG3135	benzoate transporter
HBM80_05950	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_05955	COG0543	2 iron, 2 sulfur cluster binding
HBM80_05955	COG0633	Ferredoxin
HBM80_05960	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBM80_05965	COG4638	Rieske (2fe-2S)
HBM80_05970	COG0583	DNA-binding transcription factor activity
HBM80_06020	COG1570	exodeoxyribonuclease VII activity
HBM80_06055	COG1280	lysine exporter protein (LysE YggA)
HBM80_06060	COG1278	Cold shock
HBM80_06095	COG2814	Major facilitator Superfamily
HBM80_06135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HBM80_06135	COG0517	IMP dehydrogenase activity
HBM80_06140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBM80_06150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HBM80_06155	COG1137	ATPase activity
HBM80_06165	COG1538	Outer membrane efflux protein
HBM80_06195	COG4122	O-methyltransferase activity
HBM80_06205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HBM80_06220	COG1522	sequence-specific DNA binding
HBM80_06225	COG5006	permease, DMT superfamily
HBM80_06235	COG1560	Kdo2-lipid A biosynthetic process
HBM80_06245	COG2814	Major facilitator Superfamily
HBM80_06265	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM80_06295	COG3501	Rhs element vgr protein
HBM80_06300	COG3209	COG3209 Rhs family protein
HBM80_06315	COG0583	DNA-binding transcription factor activity
HBM80_06320	COG1914	H( )-stimulated, divalent metal cation uptake system
HBM80_06340	COG4770	biotin carboxylase activity
HBM80_06345	COG0038	chloride channel
HBM80_06365	COG1309	transcriptional regulator
HBM80_06375	COG1063	alcohol dehydrogenase
HBM80_06390	COG0439	Biotin carboxylase
HBM80_06395	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM80_06415	COG0864	Transcriptional regulator
HBM80_06425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM80_06430	COG1116	anion transmembrane transporter activity
HBM80_06545	COG0590	tRNA wobble adenosine to inosine editing
HBM80_06550	COG2807	transmembrane transport
HBM80_06565	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBM80_06580	COG0789	Transcriptional regulator
HBM80_06590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM80_06610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM80_06620	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM80_06635	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_06640	COG0531	amino acid
HBM80_06645	COG1760	l-serine dehydratase
HBM80_06650	COG2030	dehydratase
HBM80_06650	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_06655	COG3396	Phenylacetate-CoA oxygenase
HBM80_06660	COG3460	Phenylacetate-CoA oxygenase
HBM80_06665	COG3396	Phenylacetate-CoA oxygenase
HBM80_06670	COG2151	metal-sulfur cluster biosynthetic enzyme
HBM80_06675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM80_06680	COG1024	Enoyl-CoA hydratase
HBM80_06685	COG1024	Enoyl-CoA hydratase
HBM80_06690	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM80_06695	COG0183	Belongs to the thiolase family
HBM80_06700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HBM80_06705	COG3327	negative regulation of DNA-templated transcription, initiation
HBM80_06715	COG2050	protein possibly involved in aromatic compounds catabolism
HBM80_06750	COG0753	catalase activity
HBM80_06755	COG3038	cytochrome b561
HBM80_06775	COG2267	carboxylic ester hydrolase activity
HBM80_06780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM80_06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM80_06790	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_06800	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBM80_06810	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_06815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBM80_06820	COG0583	DNA-binding transcription factor activity
HBM80_06830	COG1414	Transcriptional regulator
HBM80_06835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM80_06845	COG1840	ABC-type Fe3 transport system, periplasmic component
HBM80_06850	COG3842	ATPase activity
HBM80_06865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HBM80_06870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBM80_06875	COG2814	Major facilitator Superfamily
HBM80_06880	COG1960	acyl-CoA dehydrogenase activity
HBM80_06895	COG1024	Enoyl-CoA hydratase
HBM80_06905	COG2814	Major facilitator Superfamily
HBM80_06915	COG0183	Belongs to the thiolase family
HBM80_06920	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM80_06925	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_06930	COG1024	Enoyl-CoA hydratase
HBM80_06935	COG1960	acyl-CoA dehydrogenase activity
HBM80_06940	COG2814	Major facilitator Superfamily
HBM80_06945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM80_06950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM80_06960	COG2814	Major facilitator Superfamily
HBM80_06970	COG1960	acyl-CoA dehydrogenase activity
HBM80_06985	COG0583	DNA-binding transcription factor activity
HBM80_06995	COG4770	biotin carboxylase activity
HBM80_07000	COG1024	Enoyl-CoA hydratase
HBM80_07005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBM80_07010	COG1960	acyl-CoA dehydrogenase activity
HBM80_07015	COG1309	transcriptional regulator
HBM80_07020	COG0318	PFAM AMP-dependent synthetase and ligase
HBM80_07040	COG0583	DNA-binding transcription factor activity
HBM80_07090	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_07110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBM80_07130	COG0784	Response regulator, receiver
HBM80_07130	COG2205	protein histidine kinase activity
HBM80_07150	COG0765	amino acid transport
HBM80_07155	COG0765	amino acid transport
HBM80_07160	COG1126	abc transporter atp-binding protein
HBM80_07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM80_07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM80_07185	COG1280	lysine exporter protein (LysE YggA)
HBM80_07195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBM80_07200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBM80_07205	COG1045	serine acetyltransferase
HBM80_07220	COG0583	DNA-binding transcription factor activity
HBM80_07225	COG0625	glutathione transferase activity
HBM80_07230	COG0625	glutathione transferase activity
HBM80_07235	COG0583	DNA-binding transcription factor activity
HBM80_07245	COG1346	cytolysis
HBM80_07265	COG2814	Major facilitator Superfamily
HBM80_07275	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HBM80_07280	COG3052	prosthetic group binding
HBM80_07300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBM80_07320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM80_07330	COG1294	oxidase, subunit
HBM80_07335	COG1271	oxidase subunit
HBM80_07355	COG0477	Major facilitator Superfamily
HBM80_07365	COG4521	taurine ABC transporter
HBM80_07370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HBM80_07375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM80_07380	COG2175	clavaminate synthase activity
HBM80_07390	COG1953	Uracil, thiamine, allantoin
HBM80_07400	COG0583	DNA-binding transcription factor activity
HBM80_07410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HBM80_07425	COG0640	Transcriptional regulator
HBM80_07430	COG0798	PFAM Bile acid sodium symporter
HBM80_07435	COG0583	DNA-binding transcription factor activity
HBM80_07450	COG3634	alkyl hydroperoxide reductase activity
HBM80_07490	COG0436	Aminotransferase
HBM80_07500	COG0386	Belongs to the glutathione peroxidase family
HBM80_07540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBM80_07565	COG0012	GTP binding
HBM80_07570	COG2011	ABC-type metal ion transport system permease component
HBM80_07575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBM80_07585	COG1464	Belongs to the NlpA lipoprotein family
HBM80_07615	COG0765	amino acid transport
HBM80_07620	COG0765	amino acid transport
HBM80_07625	COG1126	abc transporter atp-binding protein
HBM80_07635	COG1522	sequence-specific DNA binding
HBM80_07650	COG1309	transcriptional regulator
HBM80_07670	COG0583	DNA-binding transcription factor activity
HBM80_07680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBM80_07690	COG0697	spore germination
HBM80_07715	COG3121	Chaperone
HBM80_07720	COG3539	Fimbrial protein
HBM80_07745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HBM80_07745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HBM80_07790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HBM80_07800	COG2353	YceI-like domain
HBM80_07810	COG3698	Phosphodiester glycosidase
HBM80_07825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBM80_07830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBM80_07830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBM80_07830	COG0506	proline dehydrogenase activity
HBM80_07840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBM80_07845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HBM80_07865	COG1132	(ABC) transporter
HBM80_07870	COG3122	Protein conserved in bacteria
HBM80_07875	COG3619	membrane
HBM80_07890	COG0640	Transcriptional regulator
HBM80_07900	COG2850	peptidyl-arginine hydroxylation
HBM80_07905	COG0424	maF-like protein
HBM80_07925	COG0191	fructose-bisphosphate aldolase activity
HBM80_07930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBM80_07945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBM80_07955	COG1192	Involved in chromosome partitioning
HBM80_07960	COG1475	DNA binding
HBM80_07965	COG0811	peptide transport
HBM80_07975	COG1132	(ABC) transporter
HBM80_07980	COG1663	tetraacyldisaccharide 4'-kinase activity
HBM80_08000	COG0084	hydrolase, TatD family'
HBM80_08065	COG0776	regulation of translation
HBM80_08095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HBM80_08100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HBM80_08150	COG0339	signal peptide processing
HBM80_08160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBM80_08195	COG0702	epimerase
HBM80_08200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBM80_08220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBM80_08250	COG0316	Belongs to the HesB IscA family
HBM80_08255	COG0822	iron-sulfur transferase activity
HBM80_08280	COG0776	regulation of translation
HBM80_08285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBM80_08290	COG2207	Transcriptional regulator
HBM80_08295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBM80_08300	COG1960	acyl-CoA dehydrogenase activity
HBM80_08305	COG1960	acyl-CoA dehydrogenase activity
HBM80_08320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HBM80_08340	COG4264	IucA IucC family
HBM80_08345	COG4264	IucA IucC family
HBM80_08400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HBM80_08420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBM80_08425	COG0730	response to heat
HBM80_08445	COG4773	Receptor
HBM80_08450	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM80_08465	COG1131	(ABC) transporter
HBM80_08470	COG0842	Transport permease protein
HBM80_08475	COG0842	Transport permease protein
HBM80_08530	COG2226	methyltransferase
HBM80_08555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HBM80_08590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBM80_08600	COG0133	tryptophan synthase activity
HBM80_08615	COG3706	GGDEF domain
HBM80_08630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBM80_08635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HBM80_08640	COG0022	dehydrogenase e1 component
HBM80_08645	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBM80_08650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM80_08660	COG1063	alcohol dehydrogenase
HBM80_08665	COG3781	membrane
HBM80_08675	COG3453	Protein conserved in bacteria
HBM80_08675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM80_08685	COG0730	response to heat
HBM80_08700	COG2207	Transcriptional regulator
HBM80_08700	COG3708	Transcriptional regulator
HBM80_08705	COG1733	regulation of RNA biosynthetic process
HBM80_08710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HBM80_08720	COG2188	Transcriptional regulator
HBM80_08735	COG4521	taurine ABC transporter
HBM80_08740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM80_08760	COG0477	Major facilitator Superfamily
HBM80_08770	COG1027	Aspartate ammonia-lyase
HBM80_08785	COG0583	DNA-binding transcription factor activity
HBM80_08790	COG0583	DNA-binding transcription factor activity
HBM80_08795	COG0183	Belongs to the thiolase family
HBM80_08800	COG2031	fatty acid transporter
HBM80_08805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM80_08815	COG0583	DNA-binding transcription factor activity
HBM80_08825	COG2610	gluconate transmembrane transporter activity
HBM80_08830	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_08840	COG2207	Transcriptional regulator
HBM80_08855	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_08880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM80_08880	COG0543	2 iron, 2 sulfur cluster binding
HBM80_08885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBM80_08890	COG4638	Rieske (2fe-2S)
HBM80_08900	COG0725	ABC transporter, periplasmic molybdate-binding protein
HBM80_08905	COG4149	molybdate abc transporter
HBM80_08910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HBM80_08915	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_08920	COG1535	isochorismatase
HBM80_08920	COG3433	isochorismatase activity
HBM80_08985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBM80_09000	COG0753	catalase activity
HBM80_09010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HBM80_09040	COG3539	Fimbrial protein
HBM80_09060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM80_09080	COG2072	flavoprotein involved in K transport
HBM80_09090	COG1538	Outer membrane efflux protein
HBM80_09095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBM80_09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM80_09105	COG0745	RESPONSE REGULATOR receiver
HBM80_09110	COG2205	protein histidine kinase activity
HBM80_09120	COG2207	Transcriptional regulator
HBM80_09135	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_09185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HBM80_09300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBM80_09320	COG1120	ATPase activity
HBM80_09335	COG1064	alcohol dehydrogenase
HBM80_09350	COG2207	Transcriptional regulator
HBM80_09355	COG2084	Dehydrogenase
HBM80_09365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBM80_09370	COG0583	DNA-binding transcription factor activity
HBM80_09380	COG0129	dihydroxy-acid dehydratase activity
HBM80_09385	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_09400	COG1566	PFAM secretion protein HlyD family protein
HBM80_09420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBM80_09425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBM80_09450	COG0583	DNA-binding transcription factor activity
HBM80_09465	COG2188	Transcriptional regulator
HBM80_09495	COG3210	domain, Protein
HBM80_09500	COG2831	hemolysin activation secretion protein
HBM80_09510	COG1473	amidohydrolase
HBM80_09520	COG0475	glutathione-regulated potassium exporter activity
HBM80_09520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM80_09530	COG0583	DNA-binding transcription factor activity
HBM80_09535	COG1335	isochorismatase
HBM80_09545	COG1309	transcriptional regulator
HBM80_09575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBM80_09585	COG1902	pentaerythritol trinitrate reductase activity
HBM80_09585	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM80_09590	COG1846	Transcriptional regulator
HBM80_09610	COG0753	catalase activity
HBM80_09625	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_09640	COG3162	membrane
HBM80_09650	COG3829	transcription factor binding
HBM80_09655	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_09660	COG1960	acyl-CoA dehydrogenase activity
HBM80_09680	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_09700	COG2186	Transcriptional regulator
HBM80_09710	COG0583	DNA-binding transcription factor activity
HBM80_09715	COG4948	Mandelate Racemase Muconate Lactonizing
HBM80_09720	COG4829	muconolactone delta-isomerase
HBM80_09730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM80_09735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM80_09740	COG0183	Belongs to the thiolase family
HBM80_09745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM80_09755	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_09765	COG3733	amine oxidase
HBM80_09775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM80_09785	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_09795	COG4638	Rieske (2fe-2S)
HBM80_09815	COG0154	amidase activity
HBM80_09825	COG2814	Major facilitator Superfamily
HBM80_09860	COG1960	acyl-CoA dehydrogenase activity
HBM80_09865	COG0583	DNA-binding transcription factor activity
HBM80_09870	COG1414	Transcriptional regulator
HBM80_09885	COG2391	methyltransferase activity
HBM80_09895	COG4993	Dehydrogenase
HBM80_09900	COG3659	wide pore channel activity
HBM80_09905	COG3420	alginic acid biosynthetic process
HBM80_09910	COG0710	3-dehydroquinate dehydratase activity
HBM80_09915	COG3485	protocatechuate 3,4-dioxygenase
HBM80_09920	COG3485	protocatechuate 3,4-dioxygenase
HBM80_09925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBM80_09930	COG2271	Major facilitator Superfamily
HBM80_09935	COG0596	Alpha beta hydrolase
HBM80_09940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HBM80_09945	COG0183	Belongs to the thiolase family
HBM80_09950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM80_09955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM80_09965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HBM80_09970	COG2323	membrane
HBM80_10015	COG1902	pentaerythritol trinitrate reductase activity
HBM80_10015	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM80_10040	COG0542	response to heat
HBM80_10045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HBM80_10075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBM80_10080	COG0569	domain protein
HBM80_10085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBM80_10100	COG4774	siderophore transport
HBM80_10105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBM80_10115	COG1585	Membrane protein implicated in regulation of membrane protease activity
HBM80_10130	COG1294	oxidase, subunit
HBM80_10135	COG4890	Cyd operon protein YbgT
HBM80_10150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HBM80_10160	COG0552	protein localization to endoplasmic reticulum
HBM80_10185	COG0516	GMP reductase activity
HBM80_10185	COG0517	IMP dehydrogenase activity
HBM80_10190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBM80_10195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBM80_10205	COG0583	DNA-binding transcription factor activity
HBM80_10210	COG0024	Methionine aminopeptidase
HBM80_10240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBM80_10240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBM80_10245	COG1105	Belongs to the carbohydrate kinase PfkB family
HBM80_10250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBM80_10250	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HBM80_10250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBM80_10270	COG5001	Diguanylate cyclase
HBM80_10270	COG3300	MHYT domain
HBM80_10285	COG2135	peptidase activity
HBM80_10290	COG0659	secondary active sulfate transmembrane transporter activity
HBM80_10305	COG1113	amino acid transport
HBM80_10315	COG1522	sequence-specific DNA binding
HBM80_10340	COG1011	Hydrolase
HBM80_10345	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HBM80_10355	COG2137	regulation of response to DNA damage stimulus
HBM80_10370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM80_10405	COG0575	Belongs to the CDS family
HBM80_10410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HBM80_10430	COG3852	Histidine kinase
HBM80_10435	COG2204	response regulator
HBM80_10500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBM80_10505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HBM80_10525	COG0697	spore germination
HBM80_10530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM80_10540	COG0303	'Molybdopterin
HBM80_10545	COG0315	cyclic pyranopterin monophosphate synthase activity
HBM80_10545	COG0521	Mo-molybdopterin cofactor biosynthetic process
HBM80_10560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HBM80_10565	COG0243	molybdopterin cofactor binding
HBM80_10575	COG0243	molybdopterin cofactor binding
HBM80_10580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM80_10585	COG2146	nitrite reductase [NAD(P)H] activity
HBM80_10585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM80_10595	COG0745	RESPONSE REGULATOR receiver
HBM80_10600	COG1116	anion transmembrane transporter activity
HBM80_10600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM80_10620	COG0511	ligase activity, forming carbon-carbon bonds
HBM80_10635	COG2814	Major facilitator Superfamily
HBM80_10700	COG0739	heme binding
HBM80_10825	COG5410	chromosome segregation
HBM80_10990	COG0069	glutamate synthase activity
HBM80_11010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HBM80_11020	COG1454	alcohol dehydrogenase
HBM80_11025	COG0824	Thioesterase
HBM80_11035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HBM80_11055	COG2030	dehydratase
HBM80_11065	COG0183	Belongs to the thiolase family
HBM80_11075	COG0583	DNA-binding transcription factor activity
HBM80_11080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HBM80_11090	COG1522	sequence-specific DNA binding
HBM80_11095	COG3135	benzoate transporter
HBM80_11105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HBM80_11130	COG0589	response to stress
HBM80_11135	COG0488	(ABC) transporter
HBM80_11155	COG4773	Receptor
HBM80_11190	COG0668	transmembrane transport
HBM80_11200	COG1309	transcriptional regulator
HBM80_11215	COG1605	Chorismate mutase
HBM80_11245	COG0308	aminopeptidase N
HBM80_11265	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HBM80_11275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBM80_11280	COG1454	alcohol dehydrogenase
HBM80_11300	COG0531	amino acid
HBM80_11305	COG4303	Ethanolamine ammonia lyase large subunit
HBM80_11310	COG4302	ethanolamine ammonia-lyase activity
HBM80_11315	COG0519	Catalyzes the synthesis of GMP from XMP
HBM80_11315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBM80_11320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBM80_11330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM80_11345	COG0697	spore germination
HBM80_11350	COG1923	regulation of RNA biosynthetic process
HBM80_11360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBM80_11365	COG0802	atpase or kinase
HBM80_11385	COG1187	pseudouridine synthase activity
HBM80_11400	COG0583	DNA-binding transcription factor activity
HBM80_11415	COG2814	Major facilitator Superfamily
HBM80_11420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBM80_11445	COG0729	surface antigen
HBM80_11465	COG0174	glutamine synthetase
HBM80_11470	COG0745	RESPONSE REGULATOR receiver
HBM80_11475	COG2205	protein histidine kinase activity
HBM80_11485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HBM80_11490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HBM80_11515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM80_11520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM80_11525	COG1960	acyl-CoA dehydrogenase activity
HBM80_11540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM80_11545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM80_11565	COG0583	DNA-binding transcription factor activity
HBM80_11580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM80_11590	COG3658	cytochrome
HBM80_11595	COG1215	transferase activity, transferring glycosyl groups
HBM80_11600	COG1649	PFAM Uncharacterised BCR, COG1649
HBM80_11600	COG0726	polysaccharide deacetylase
HBM80_11625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HBM80_11630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HBM80_11640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HBM80_11665	COG0305	Participates in initiation and elongation during chromosome replication
HBM80_11670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HBM80_11680	COG1305	Transglutaminase-like
HBM80_11690	COG2308	Evidence 4 Homologs of previously reported genes of
HBM80_11720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBM80_11725	COG0138	bifunctional purine biosynthesis protein purh
HBM80_11730	COG0151	Belongs to the GarS family
HBM80_11735	COG1464	Belongs to the NlpA lipoprotein family
HBM80_11740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBM80_11745	COG2011	ABC-type metal ion transport system permease component
HBM80_11750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM80_11760	COG1301	dicarboxylic acid transport
HBM80_11790	COG3173	Aminoglycoside phosphotransferase
HBM80_11810	COG0482	sulfurtransferase activity
HBM80_11830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBM80_11830	COG3008	intermembrane lipid transfer
HBM80_11835	COG2995	paraquat-inducible protein a
HBM80_11845	COG2985	domain, Protein
HBM80_11870	COG0477	Major facilitator Superfamily
HBM80_11920	COG2186	Transcriptional regulator
HBM80_11930	COG0786	glutamate:sodium symporter activity
HBM80_11935	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBM80_11960	COG3111	PFAM Bacterial OB fold (BOF) protein
HBM80_12060	COG1610	YqeY-like protein
HBM80_12065	COG4783	chaperone-mediated protein folding
HBM80_12090	COG1286	toxin biosynthetic process
HBM80_12120	COG0778	Nitroreductase
HBM80_12130	COG0513	Belongs to the DEAD box helicase family
HBM80_12150	COG2363	Small membrane protein
HBM80_12180	COG1234	tRNA 3'-trailer cleavage
HBM80_12185	COG2195	Cleaves the N-terminal amino acid of tripeptides
HBM80_12195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HBM80_12205	COG2819	hydrolase of the alpha beta superfamily
HBM80_12210	COG1960	acyl-CoA dehydrogenase activity
HBM80_12215	COG1301	dicarboxylic acid transport
HBM80_12220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBM80_12225	COG3139	Protein of unknown function (DUF1315)
HBM80_12230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HBM80_12235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HBM80_12245	COG0494	nUDIX hydrolase
HBM80_12255	COG0642	Histidine kinase
HBM80_12260	COG0745	RESPONSE REGULATOR receiver
HBM80_12280	COG1720	tRNA m6t6A37 methyltransferase activity
HBM80_12295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM80_12305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBM80_12315	COG4598	ABC transporter
HBM80_12320	COG4160	amino acid transport
HBM80_12325	COG4215	(ABC) transporter
HBM80_12340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM80_12385	COG1131	(ABC) transporter
HBM80_12390	COG0842	Transport permease protein
HBM80_12405	COG0772	Belongs to the SEDS family
HBM80_12410	COG2951	lytic endotransglycosylase activity
HBM80_12435	COG2207	Transcriptional regulator
HBM80_12450	COG0052	Belongs to the universal ribosomal protein uS2 family
HBM80_12455	COG0024	Methionine aminopeptidase
HBM80_12465	COG2223	nitrite transmembrane transporter activity
HBM80_12475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM80_12480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBM80_12485	COG1960	acyl-CoA dehydrogenase activity
HBM80_12500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBM80_12505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HBM80_12510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBM80_12530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBM80_12535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HBM80_12540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HBM80_12575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBM80_12585	COG0174	glutamine synthetase
HBM80_12590	COG3104	oligopeptide transport
HBM80_12600	COG0582	viral genome integration into host DNA
HBM80_12755	COG5410	chromosome segregation
HBM80_12930	COG0512	Glutamine amidotransferase of anthranilate synthase
HBM80_12935	COG0308	aminopeptidase N
HBM80_12965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HBM80_13000	COG3739	integral membrane protein
HBM80_13015	COG1169	isochorismate synthase
HBM80_13025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HBM80_13035	COG1132	(ABC) transporter
HBM80_13050	COG1535	isochorismatase
HBM80_13050	COG3433	isochorismatase activity
HBM80_13055	COG1021	2,3-dihydroxybenzoate-AMP ligase
HBM80_13060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM80_13070	COG4774	siderophore transport
HBM80_13075	COG4607	ABC-type enterochelin transport system periplasmic component
HBM80_13080	COG4604	ABC transporter, ATP-binding protein
HBM80_13085	COG4605	iron ion homeostasis
HBM80_13090	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBM80_13095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM80_13110	COG2964	Protein conserved in bacteria
HBM80_13120	COG1741	Belongs to the pirin family
HBM80_13140	COG1309	transcriptional regulator
HBM80_13150	COG4948	Mandelate Racemase Muconate Lactonizing
HBM80_13155	COG2814	Major facilitator Superfamily
HBM80_13190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM80_13190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HBM80_13195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM80_13200	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_13210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM80_13215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM80_13220	COG0583	DNA-binding transcription factor activity
HBM80_13225	COG1113	amino acid transport
HBM80_13245	COG2508	Transcriptional regulator
HBM80_13245	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HBM80_13280	COG2879	small protein
HBM80_13285	COG1966	Carbon starvation protein
HBM80_13330	COG1067	ATP-dependent peptidase activity
HBM80_13335	COG0583	DNA-binding transcription factor activity
HBM80_13360	COG1686	Belongs to the peptidase S11 family
HBM80_13365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HBM80_13395	COG3328	transposase activity
HBM80_13405	COG0616	signal peptide processing
HBM80_13410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HBM80_13420	COG0573	inorganic phosphate transmembrane transporter activity
HBM80_13425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HBM80_13430	COG1113	amino acid transport
HBM80_13435	COG3961	Belongs to the TPP enzyme family
HBM80_13440	COG1522	sequence-specific DNA binding
HBM80_13450	COG0076	glutamate decarboxylase activity
HBM80_13455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBM80_13465	COG1309	transcriptional regulator
HBM80_13480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM80_13515	COG0352	thiamine-phosphate diphosphorylase activity
HBM80_13540	COG0612	Peptidase, M16
HBM80_13555	COG0583	DNA-binding transcription factor activity
HBM80_13560	COG0477	Major facilitator Superfamily
HBM80_13585	COG1187	pseudouridine synthase activity
HBM80_13600	COG1686	Belongs to the peptidase S11 family
HBM80_13605	COG1252	NADH dehydrogenase
HBM80_13615	COG0415	Belongs to the DNA photolyase family
HBM80_13630	COG1215	transferase activity, transferring glycosyl groups
HBM80_13660	COG2070	2-Nitropropane dioxygenase
HBM80_13715	COG0556	nucleotide-excision repair
HBM80_13735	COG0436	Aminotransferase
HBM80_13765	COG4221	oxidoreductase activity
HBM80_13775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HBM80_13780	COG1381	Involved in DNA repair and RecF pathway recombination
HBM80_13790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HBM80_13805	COG0681	Belongs to the peptidase S26 family
HBM80_13820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBM80_13840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBM80_13845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBM80_13850	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HBM80_13860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HBM80_13865	COG4208	sulfate ABC transporter
HBM80_13870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HBM80_13875	COG0583	DNA-binding transcription factor activity
HBM80_13880	COG4625	pathogenesis
HBM80_13895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HBM80_13910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBM80_13920	COG1056	cytidyltransferase-related domain
HBM80_13920	COG1051	belongs to the nudix hydrolase family
HBM80_13925	COG1024	Enoyl-CoA hydratase
HBM80_13935	COG2814	Major facilitator Superfamily
HBM80_13940	COG0047	phosphoribosylformylglycinamidine synthase activity
HBM80_13940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HBM80_13960	COG1473	amidohydrolase
HBM80_13965	COG0824	Thioesterase
HBM80_13985	COG0823	Involved in the tonB-independent uptake of proteins
HBM80_14005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBM80_14040	COG0628	permease
HBM80_14050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBM80_14055	COG0596	Alpha beta hydrolase
HBM80_14060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBM80_14060	COG0616	signal peptide processing
HBM80_14070	COG2333	competence protein COMEC
HBM80_14070	COG0658	competence protein
HBM80_14075	COG1136	(ABC) transporter
HBM80_14080	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBM80_14115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM80_14135	COG0463	Glycosyl transferase, family 2
HBM80_14165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBM80_14170	COG1280	lysine exporter protein (LysE YggA)
HBM80_14180	COG0019	diaminopimelate decarboxylase activity
HBM80_14190	COG1113	amino acid transport
HBM80_14205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HBM80_14215	COG3339	Conserved Protein
HBM80_14220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HBM80_14225	COG0243	molybdopterin cofactor binding
HBM80_14230	COG1929	Belongs to the glycerate kinase type-1 family
HBM80_14245	COG0778	Nitroreductase
HBM80_14270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM80_14285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HBM80_14305	COG0741	lytic transglycosylase activity
HBM80_14325	COG0584	glycerophosphoryl diester phosphodiesterase
HBM80_14355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBM80_14360	COG1597	lipid kinase activity
HBM80_14375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBM80_14380	COG0477	Major facilitator Superfamily
HBM80_14430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBM80_14435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBM80_14460	COG0505	Belongs to the CarA family
HBM80_14480	COG0589	response to stress
HBM80_14495	COG2843	Capsule synthesis protein
HBM80_14535	COG2321	neutral zinc metallopeptidase
HBM80_14540	COG2354	Protein conserved in bacteria
HBM80_14560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM80_14585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBM80_14590	COG1053	succinate dehydrogenase
HBM80_14595	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HBM80_14600	COG2009	succinate dehydrogenase
HBM80_14640	COG2921	Belongs to the UPF0250 family
HBM80_14645	COG0321	lipoyl(octanoyl) transferase activity
HBM80_14660	COG0531	amino acid
HBM80_14670	COG1733	regulation of RNA biosynthetic process
HBM80_14675	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBM80_14680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBM80_14680	COG1648	precorrin-2 dehydrogenase activity
HBM80_14695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HBM80_14725	COG0671	phosphoesterase, PA-phosphatase related
HBM80_14730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM80_14740	COG1538	Outer membrane efflux protein
HBM80_14745	COG0393	Putative heavy-metal-binding
HBM80_14750	COG0393	Putative heavy-metal-binding
HBM80_14760	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_14770	COG0525	valine-tRNA ligase activity
HBM80_14790	COG0583	DNA-binding transcription factor activity
HBM80_14795	COG0004	ammonium transporteR
HBM80_14805	COG0642	Histidine kinase
HBM80_14810	COG0745	RESPONSE REGULATOR receiver
HBM80_14815	COG2194	sulfuric ester hydrolase activity
HBM80_14835	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBM80_14850	COG2315	Protein conserved in bacteria
HBM80_14855	COG0142	geranyltranstransferase activity
HBM80_14860	COG2828	Protein conserved in bacteria
HBM80_14865	COG1113	amino acid transport
HBM80_14885	COG2207	Transcriptional regulator
HBM80_14910	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM80_14920	COG0560	Phosphoserine phosphatase
HBM80_14930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM80_14940	COG1530	ribonuclease E activity
HBM80_14945	COG0424	maF-like protein
HBM80_14950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HBM80_14955	COG1792	Involved in formation and maintenance of cell shape
HBM80_14960	COG1077	Cell shape determining protein MreB Mrl
HBM80_14965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBM80_14975	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBM80_15015	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HBM80_15020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBM80_15025	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBM80_15030	COG1115	amino acid carrier protein
HBM80_15050	COG2814	Major facilitator Superfamily
HBM80_15055	COG1289	transmembrane transporter activity
HBM80_15065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HBM80_15105	COG1376	ErfK ybiS ycfS ynhG family protein
HBM80_15110	COG2832	Protein of unknown function (DUF454)
HBM80_15120	COG5510	response to toxic substance
HBM80_15140	COG0840	transmembrane signaling receptor activity
HBM80_15180	COG3422	double-strand break repair
HBM80_15185	COG2824	Alkylphosphonate utilization operon protein PhnA
HBM80_15190	COG3189	MarR family transcriptional regulator
HBM80_15200	COG0354	folic acid binding
HBM80_15205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM80_15215	COG0679	Auxin Efflux Carrier
HBM80_15220	COG1902	pentaerythritol trinitrate reductase activity
HBM80_15235	COG4772	TonB-dependent receptor
HBM80_15240	COG2094	Belongs to the DNA glycosylase MPG family
HBM80_15270	COG2233	PERMEase
HBM80_15280	COG0833	amino acid
HBM80_15285	COG1690	Belongs to the RtcB family
HBM80_15295	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBM80_15295	COG2885	chlorophyll binding
HBM80_15305	COG0183	Belongs to the thiolase family
HBM80_15325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM80_15345	COG2207	Transcriptional regulator
HBM80_15350	COG0183	Belongs to the thiolase family
HBM80_15385	COG1272	protein, Hemolysin III
HBM80_15390	COG0477	Major facilitator Superfamily
HBM80_15405	COG0450	alkyl hydroperoxide reductase
HBM80_15425	COG0285	dihydrofolate synthase activity
HBM80_15475	COG2096	Adenosyltransferase
HBM80_15495	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HBM80_15500	COG0745	RESPONSE REGULATOR receiver
HBM80_15505	COG2205	protein histidine kinase activity
HBM80_15515	COG1960	acyl-CoA dehydrogenase activity
HBM80_15520	COG1960	acyl-CoA dehydrogenase activity
HBM80_15525	COG0583	DNA-binding transcription factor activity
HBM80_15530	COG0625	glutathione transferase activity
HBM80_15600	COG0438	transferase activity, transferring glycosyl groups
HBM80_15605	COG0463	Glycosyl transferase, family 2
HBM80_15610	COG0726	polysaccharide deacetylase
HBM80_15630	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HBM80_15635	COG2205	protein histidine kinase activity
HBM80_15665	COG1862	Preprotein translocase
HBM80_15675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBM80_15680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBM80_15690	COG3781	membrane
HBM80_15695	COG0613	PHP domain protein
HBM80_15705	COG2350	Protein conserved in bacteria
HBM80_15735	COG1607	acyl-coa hydrolase
HBM80_15795	COG2199	diguanylate cyclase activity
HBM80_15805	COG1408	metallophosphoesterase
HBM80_15810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBM80_15820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBM80_15840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HBM80_15845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HBM80_15860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HBM80_15870	COG2969	positive regulation of protein catabolic process
HBM80_15890	COG1960	acyl-CoA dehydrogenase activity
HBM80_15895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBM80_15910	COG1309	transcriptional regulator
HBM80_15915	COG1960	acyl-CoA dehydrogenase activity
HBM80_15960	COG1183	phosphatidylcholine synthase activity
HBM80_15965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBM80_15995	COG1196	nuclear chromosome segregation
HBM80_15995	COG0741	lytic transglycosylase activity
HBM80_15995	COG0739	heme binding
HBM80_16005	COG1702	phosphate starvation-inducible protein PhoH
HBM80_16040	COG1295	ribonuclease BN
HBM80_16045	COG0697	spore germination
HBM80_16050	COG2169	Transcriptional regulator
HBM80_16055	COG0179	Fumarylacetoacetate (FAA) hydrolase
HBM80_16100	COG0557	exoribonuclease II activity
HBM80_16105	COG0339	signal peptide processing
HBM80_16110	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HBM80_16140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HBM80_16145	COG1960	acyl-CoA dehydrogenase activity
HBM80_16300	COG0626	cystathionine gamma-synthase activity
HBM80_16305	COG0433	COG0433 Predicted ATPase
HBM80_16310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM80_16310	COG1017	nitric oxide dioxygenase activity
HBM80_16315	COG1959	2 iron, 2 sulfur cluster binding
HBM80_16330	COG1301	dicarboxylic acid transport
HBM80_16335	COG1946	Acyl-CoA thioesterase
HBM80_16355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HBM80_16360	COG1040	competence protein
HBM80_16365	COG0494	nUDIX hydrolase
HBM80_16375	COG0598	Magnesium transport protein CorA
HBM80_16385	COG2854	intermembrane phospholipid transfer
HBM80_16395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBM80_16400	COG1127	ABC transporter
HBM80_16410	COG0513	Belongs to the DEAD box helicase family
HBM80_16430	COG0408	coproporphyrinogen oxidase activity
HBM80_16445	COG1960	acyl-CoA dehydrogenase activity
HBM80_16455	COG1983	PspC domain protein
HBM80_16460	COG0517	IMP dehydrogenase activity
HBM80_16505	COG0583	DNA-binding transcription factor activity
HBM80_16545	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_16555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBM80_16560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBM80_16565	COG0833	amino acid
HBM80_16595	COG1192	Involved in chromosome partitioning
HBM80_16600	COG0628	permease
HBM80_16610	COG1289	transmembrane transporter activity
HBM80_16625	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM80_16630	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HBM80_16640	COG0277	FAD linked oxidase domain protein
HBM80_16645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBM80_16670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HBM80_16675	COG5380	lipid catabolic process
HBM80_16695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HBM80_16745	COG0194	GDP metabolic process
HBM80_16760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBM80_16780	COG3307	-O-antigen
HBM80_16800	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HBM80_16805	COG1704	LemA family
HBM80_16815	COG0493	'glutamate synthase
HBM80_16820	COG0067	glutamate synthase
HBM80_16820	COG0069	glutamate synthase activity
HBM80_16820	COG0070	glutamate synthase
HBM80_16870	COG2226	methyltransferase
HBM80_16885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBM80_16890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBM80_16935	COG0833	amino acid
HBM80_17020	COG0488	(ABC) transporter
HBM80_17025	COG2873	o-acetylhomoserine
HBM80_17030	COG4221	oxidoreductase activity
HBM80_17035	COG0659	secondary active sulfate transmembrane transporter activity
HBM80_17045	COG0745	RESPONSE REGULATOR receiver
HBM80_17060	COG0427	acetyl-CoA hydrolase
HBM80_17090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HBM80_17120	COG2329	Antibiotic biosynthesis monooxygenase
HBM80_17135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HBM80_17200	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM80_17205	COG1733	regulation of RNA biosynthetic process
HBM80_17235	COG0667	Aldo Keto reductase
HBM80_17255	COG0583	DNA-binding transcription factor activity
HBM80_17260	COG2814	Major facilitator Superfamily
HBM80_17290	COG1335	isochorismatase
HBM80_17300	COG1012	belongs to the aldehyde dehydrogenase family
HBM80_17305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBM80_17315	COG1113	amino acid transport
HBM80_17325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBM80_17340	COG2814	Major facilitator Superfamily
HBM80_17350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBM80_17350	COG0352	thiamine-phosphate diphosphorylase activity
HBM80_17350	COG0351	phosphomethylpyrimidine kinase
HBM80_17370	COG1309	transcriptional regulator
HBM80_17375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HBM80_17385	COG3706	GGDEF domain
HBM80_17395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM80_17405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBM80_17410	COG3162	membrane
HBM80_17415	COG2198	Histidine kinase
HBM80_17415	COG0784	Response regulator, receiver
HBM80_17415	COG2205	protein histidine kinase activity
HBM80_17440	COG3328	transposase activity
HBM80_17445	COG1522	sequence-specific DNA binding
HBM80_17450	COG1335	isochorismatase
HBM80_17455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM80_17465	COG0668	transmembrane transport
HBM80_17470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBM80_17475	COG1519	Transferase
HBM80_17480	COG1902	pentaerythritol trinitrate reductase activity
HBM80_17500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HBM80_17525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM80_17525	COG0426	domain, Protein
HBM80_17530	COG4774	siderophore transport
HBM80_17535	COG2119	membrane
HBM80_17545	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBM80_17555	COG4942	peptidase
HBM80_17570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBM80_17580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HBM80_17600	COG0189	ligase activity
HBM80_17620	COG0708	Exodeoxyribonuclease III
HBM80_17625	COG1393	Belongs to the ArsC family
HBM80_17640	COG3706	GGDEF domain
HBM80_17675	COG2351	hydroxyisourate hydrolase activity
HBM80_17680	COG2233	PERMEase
HBM80_17690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM80_17700	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HBM80_17705	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_17715	COG3150	esterase
HBM80_17730	COG0791	NLP P60 protein
HBM80_17730	COG1388	LysM domain
HBM80_17735	COG3501	Rhs element vgr protein
HBM80_17745	COG2918	glutathione biosynthetic process
HBM80_17760	COG2733	membrane
HBM80_17765	COG0436	Aminotransferase
HBM80_17770	COG0534	Mate efflux family protein
HBM80_17870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HBM80_17875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBM80_17885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HBM80_17890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBM80_17905	COG0010	Belongs to the arginase family
HBM80_17935	COG2188	Transcriptional regulator
HBM80_17945	COG0523	cobalamin synthesis protein
HBM80_17955	COG1113	amino acid transport
HBM80_17965	COG0625	glutathione transferase activity
HBM80_17985	COG1683	Conserved Protein
HBM80_17990	COG0534	Mate efflux family protein
HBM80_17995	COG0385	Bile acid
HBM80_18000	COG1335	isochorismatase
HBM80_18005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM80_18025	COG2116	formate transmembrane transporter activity
HBM80_18030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBM80_18035	COG2133	pyrroloquinoline quinone binding
HBM80_18040	COG2983	Belongs to the UPF0260 family
HBM80_18060	COG1194	a g-specific adenine glycosylase
HBM80_18075	COG2818	Glycosylase
HBM80_18080	COG1064	alcohol dehydrogenase
HBM80_18085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM80_18100	COG0583	DNA-binding transcription factor activity
HBM80_18105	COG0656	L-ascorbic acid biosynthetic process
HBM80_18110	COG2814	Major facilitator Superfamily
HBM80_18145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM80_18160	COG2233	PERMEase
HBM80_18200	COG0733	neurotransmitter:sodium symporter activity
HBM80_18240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBM80_18295	COG2951	lytic endotransglycosylase activity
HBM80_18300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBM80_18315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBM80_18325	COG0671	phosphoesterase, PA-phosphatase related
HBM80_18330	COG0861	Integral membrane protein TerC family
HBM80_18340	COG0754	glutathionylspermidine amidase activity
HBM80_18350	COG0402	S-adenosylhomocysteine deaminase activity
HBM80_18365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM80_18370	COG1230	cation diffusion facilitator family transporter
HBM80_18385	COG0706	membrane insertase activity
HBM80_18410	COG0592	DNA-directed DNA polymerase activity
HBM80_18420	COG0187	DNA topoisomerase II activity
HBM80_18430	COG0586	Pfam SNARE associated Golgi protein
HBM80_18435	COG0488	(ABC) transporter
HBM80_18460	COG0596	Alpha beta hydrolase
HBM80_18465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HBM80_18470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HBM80_18510	COG1047	Peptidyl-prolyl cis-trans
HBM80_18520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HBM80_18525	COG0196	riboflavin kinase activity
HBM80_18535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HBM80_18540	COG1309	transcriptional regulator
HBM80_18545	COG1116	anion transmembrane transporter activity
HBM80_18550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM80_18555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM80_18560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM80_18565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM80_18585	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_18590	COG0546	phosphoglycolate phosphatase activity
HBM80_18645	COG3023	N-Acetylmuramoyl-L-alanine amidase
HBM80_18650	COG0728	peptidoglycan biosynthetic process
HBM80_18675	COG1596	polysaccharide export
HBM80_18680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HBM80_18690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HBM80_18695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HBM80_18700	COG2089	acid synthase
HBM80_18705	COG1045	serine acetyltransferase
HBM80_18710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBM80_18715	COG0673	inositol 2-dehydrogenase activity
HBM80_18720	COG1083	cytidylyl-transferase
HBM80_18725	COG1028	Short-chain dehydrogenase reductase Sdr
HBM80_18755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HBM80_18770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HBM80_18775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HBM80_18780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBM80_18795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBM80_18800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM80_18810	COG2186	Transcriptional regulator
HBM80_18820	COG0277	FAD linked oxidase domain protein
HBM80_18825	COG1448	Aminotransferase
HBM80_18835	COG1802	Transcriptional regulator
HBM80_18850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HBM80_18910	COG0564	pseudouridine synthase activity
HBM80_18950	COG0251	oxidation-reduction process
HBM80_18955	COG1113	amino acid transport
HBM80_18960	COG1113	amino acid transport
HBM80_18980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM80_18985	COG1960	acyl-CoA dehydrogenase activity
HBM80_18990	COG1024	Enoyl-CoA hydratase
HBM80_18995	COG1024	Enoyl-CoA hydratase
HBM80_19000	COG0477	Major facilitator Superfamily
HBM80_19005	COG3916	Acyl-homoserine-lactone synthase
HBM80_19015	COG2197	response regulator
HBM80_19025	COG1960	acyl-CoA dehydrogenase activity
HBM80_19030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HBM80_19030	COG3321	synthase
HBM80_19030	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HBM80_19030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBM80_19040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM80_19055	COG2267	carboxylic ester hydrolase activity
HBM80_19075	COG0271	Belongs to the BolA IbaG family
HBM80_19085	COG1192	Involved in chromosome partitioning
HBM80_19100	COG0586	Pfam SNARE associated Golgi protein
HBM80_19105	COG2259	Doxx family
HBM80_19110	COG4399	Belongs to the UPF0754 family
HBM80_19115	COG0519	Catalyzes the synthesis of GMP from XMP
HBM80_19115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBM80_19160	COG0281	malic enzyme
HBM80_19170	COG2837	iron assimilation
HBM80_19175	COG1280	lysine exporter protein (LysE YggA)
HBM80_19180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBM80_19185	COG1121	(ABC) transporter
HBM80_19250	COG0386	Belongs to the glutathione peroxidase family
HBM80_19265	COG1309	transcriptional regulator
HBM80_19270	COG0697	spore germination
HBM80_19280	COG0758	DNA mediated transformation
HBM80_19315	COG1309	transcriptional regulator
HBM80_19350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBM80_19405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBM80_19425	COG1253	flavin adenine dinucleotide binding
HBM80_19435	COG2860	membrane
HBM80_19440	COG0477	Major facilitator Superfamily
HBM80_19450	COG0318	PFAM AMP-dependent synthetase and ligase
HBM80_19465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBM80_19480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM80_19495	COG0606	chelatase, subunit chli
HBM80_19535	COG0589	response to stress
HBM80_19540	COG0659	secondary active sulfate transmembrane transporter activity
HBM80_19555	COG1061	Type III restriction enzyme res subunit
HBM80_19590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily