locus-tag	class	description
D8O08_000090	COG0606	chelatase, subunit chli
D8O08_000095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8O08_000105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8O08_000120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D8O08_000135	COG0318	PFAM AMP-dependent synthetase and ligase
D8O08_000145	COG0477	Major facilitator Superfamily
D8O08_000150	COG2860	membrane
D8O08_000155	COG3012	SEC-C Motif Domain Protein
D8O08_000160	COG1253	flavin adenine dinucleotide binding
D8O08_000170	COG2814	Major facilitator Superfamily
D8O08_000180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D8O08_000215	COG0655	NAD(P)H dehydrogenase (quinone) activity
D8O08_000225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D8O08_000260	COG1309	transcriptional regulator
D8O08_000305	COG0697	spore germination
D8O08_000310	COG1309	transcriptional regulator
D8O08_000325	COG0386	Belongs to the glutathione peroxidase family
D8O08_000390	COG1121	(ABC) transporter
D8O08_000395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D8O08_000400	COG1280	lysine exporter protein (LysE YggA)
D8O08_000405	COG2837	iron assimilation
D8O08_000410	COG0281	malic enzyme
D8O08_000455	COG0519	Catalyzes the synthesis of GMP from XMP
D8O08_000455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8O08_000460	COG4399	Belongs to the UPF0754 family
D8O08_000465	COG2259	Doxx family
D8O08_000470	COG0586	Pfam SNARE associated Golgi protein
D8O08_000485	COG1192	Involved in chromosome partitioning
D8O08_000495	COG0271	Belongs to the BolA IbaG family
D8O08_000515	COG2267	carboxylic ester hydrolase activity
D8O08_000535	COG3321	synthase
D8O08_000535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8O08_000535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8O08_000535	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D8O08_000540	COG1960	acyl-CoA dehydrogenase activity
D8O08_000550	COG2197	response regulator
D8O08_000560	COG3916	Acyl-homoserine-lactone synthase
D8O08_000565	COG0477	Major facilitator Superfamily
D8O08_000570	COG1024	Enoyl-CoA hydratase
D8O08_000575	COG1024	Enoyl-CoA hydratase
D8O08_000580	COG1960	acyl-CoA dehydrogenase activity
D8O08_000585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8O08_000605	COG1113	amino acid transport
D8O08_000610	COG1113	amino acid transport
D8O08_000615	COG0251	oxidation-reduction process
D8O08_000630	COG1522	sequence-specific DNA binding
D8O08_000655	COG0564	pseudouridine synthase activity
D8O08_000670	COG3328	transposase activity
D8O08_000705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D8O08_000720	COG1802	Transcriptional regulator
D8O08_000730	COG1448	Aminotransferase
D8O08_000735	COG0277	FAD linked oxidase domain protein
D8O08_000745	COG2186	Transcriptional regulator
D8O08_000755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8O08_000760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8O08_000775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D8O08_000790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8O08_000805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D8O08_000855	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_000860	COG1083	cytidylyl-transferase
D8O08_000865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D8O08_000875	COG2089	acid synthase
D8O08_000885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D8O08_000895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D8O08_000925	COG0728	peptidoglycan biosynthetic process
D8O08_000930	COG3023	N-Acetylmuramoyl-L-alanine amidase
D8O08_000985	COG0546	phosphoglycolate phosphatase activity
D8O08_000990	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_001010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8O08_001015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8O08_001020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8O08_001025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8O08_001030	COG1116	anion transmembrane transporter activity
D8O08_001035	COG1309	transcriptional regulator
D8O08_001040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8O08_001055	COG0196	riboflavin kinase activity
D8O08_001060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D8O08_001070	COG1047	Peptidyl-prolyl cis-trans
D8O08_001110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D8O08_001165	COG2951	lytic endotransglycosylase activity
D8O08_001170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D8O08_001190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8O08_001200	COG0671	phosphoesterase, PA-phosphatase related
D8O08_001205	COG0861	Integral membrane protein TerC family
D8O08_001225	COG0402	S-adenosylhomocysteine deaminase activity
D8O08_001240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8O08_001245	COG1230	cation diffusion facilitator family transporter
D8O08_001260	COG0706	membrane insertase activity
D8O08_001275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D8O08_001285	COG0592	DNA-directed DNA polymerase activity
D8O08_001295	COG0187	DNA topoisomerase II activity
D8O08_001305	COG0586	Pfam SNARE associated Golgi protein
D8O08_001310	COG0488	(ABC) transporter
D8O08_001340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D8O08_001345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D8O08_001390	COG0733	neurotransmitter:sodium symporter activity
D8O08_001400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8O08_001425	COG0583	DNA-binding transcription factor activity
D8O08_001430	COG2233	PERMEase
D8O08_001445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8O08_001480	COG2814	Major facilitator Superfamily
D8O08_001485	COG0656	L-ascorbic acid biosynthetic process
D8O08_001490	COG0583	DNA-binding transcription factor activity
D8O08_001505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8O08_001510	COG1064	alcohol dehydrogenase
D8O08_001515	COG2818	Glycosylase
D8O08_001530	COG1194	a g-specific adenine glycosylase
D8O08_001540	COG0400	carboxylic ester hydrolase activity
D8O08_001550	COG2983	Belongs to the UPF0260 family
D8O08_001555	COG2133	pyrroloquinoline quinone binding
D8O08_001560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8O08_001585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8O08_001590	COG1335	isochorismatase
D8O08_001595	COG0385	Bile acid
D8O08_001600	COG0534	Mate efflux family protein
D8O08_001605	COG1683	Conserved Protein
D8O08_001625	COG0625	glutathione transferase activity
D8O08_001635	COG1113	amino acid transport
D8O08_001645	COG0523	cobalamin synthesis protein
D8O08_001685	COG0010	Belongs to the arginase family
D8O08_001700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D8O08_001705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D8O08_001715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D8O08_001720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D8O08_001830	COG0534	Mate efflux family protein
D8O08_001835	COG0436	Aminotransferase
D8O08_001840	COG2733	membrane
D8O08_001855	COG2918	glutathione biosynthetic process
D8O08_001865	COG3501	Rhs element vgr protein
D8O08_001910	COG1324	tolerance protein
D8O08_001915	COG0673	inositol 2-dehydrogenase activity
D8O08_001955	COG3150	esterase
D8O08_001965	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_001970	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D8O08_001980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8O08_001990	COG2233	PERMEase
D8O08_001995	COG2351	hydroxyisourate hydrolase activity
D8O08_002030	COG3706	GGDEF domain
D8O08_002045	COG1393	Belongs to the ArsC family
D8O08_002050	COG0708	Exodeoxyribonuclease III
D8O08_002070	COG0189	ligase activity
D8O08_002090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D8O08_002100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D8O08_002115	COG4942	peptidase
D8O08_002125	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8O08_002135	COG2119	membrane
D8O08_002140	COG4774	siderophore transport
D8O08_002145	COG0426	domain, Protein
D8O08_002145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8O08_002170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8O08_002190	COG1902	pentaerythritol trinitrate reductase activity
D8O08_002195	COG1519	Transferase
D8O08_002200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8O08_002205	COG0668	transmembrane transport
D8O08_002215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8O08_002220	COG1335	isochorismatase
D8O08_002225	COG1522	sequence-specific DNA binding
D8O08_002250	COG2198	Histidine kinase
D8O08_002250	COG2205	protein histidine kinase activity
D8O08_002250	COG0784	Response regulator, receiver
D8O08_002255	COG3162	membrane
D8O08_002260	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8O08_002270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8O08_002280	COG3706	GGDEF domain
D8O08_002300	COG1061	Type III restriction enzyme res subunit
D8O08_002325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D8O08_002330	COG1309	transcriptional regulator
D8O08_002350	COG0352	thiamine-phosphate diphosphorylase activity
D8O08_002350	COG0351	phosphomethylpyrimidine kinase
D8O08_002350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D8O08_002360	COG2814	Major facilitator Superfamily
D8O08_002375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D8O08_002385	COG1113	amino acid transport
D8O08_002395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8O08_002400	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_002410	COG1335	isochorismatase
D8O08_002440	COG2814	Major facilitator Superfamily
D8O08_002445	COG0583	DNA-binding transcription factor activity
D8O08_002465	COG0667	Aldo Keto reductase
D8O08_002560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D8O08_002605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D8O08_002635	COG0427	acetyl-CoA hydrolase
D8O08_002650	COG0745	RESPONSE REGULATOR receiver
D8O08_002660	COG0659	secondary active sulfate transmembrane transporter activity
D8O08_002665	COG4221	oxidoreductase activity
D8O08_002675	COG0488	(ABC) transporter
D8O08_002760	COG0833	amino acid
D8O08_002805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D8O08_002810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8O08_002825	COG2226	methyltransferase
D8O08_002875	COG0070	glutamate synthase
D8O08_002875	COG0067	glutamate synthase
D8O08_002875	COG0069	glutamate synthase activity
D8O08_002890	COG1704	LemA family
D8O08_002895	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D8O08_002915	COG3307	-O-antigen
D8O08_002955	COG0194	GDP metabolic process
D8O08_003005	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D8O08_003025	COG5380	lipid catabolic process
D8O08_003030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D8O08_003055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8O08_003060	COG0277	FAD linked oxidase domain protein
D8O08_003070	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D8O08_003075	COG2249	NAD(P)H dehydrogenase (quinone) activity
D8O08_003090	COG1289	transmembrane transporter activity
D8O08_003100	COG0628	permease
D8O08_003105	COG1192	Involved in chromosome partitioning
D8O08_003135	COG0833	amino acid
D8O08_003140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8O08_003145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8O08_003155	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_003200	COG0583	DNA-binding transcription factor activity
D8O08_003245	COG0517	IMP dehydrogenase activity
D8O08_003250	COG1983	PspC domain protein
D8O08_003260	COG1960	acyl-CoA dehydrogenase activity
D8O08_003280	COG0408	coproporphyrinogen oxidase activity
D8O08_003300	COG0513	Belongs to the DEAD box helicase family
D8O08_003310	COG1127	ABC transporter
D8O08_003315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8O08_003325	COG2854	intermembrane phospholipid transfer
D8O08_003335	COG0598	Magnesium transport protein CorA
D8O08_003345	COG0494	nUDIX hydrolase
D8O08_003350	COG1040	competence protein
D8O08_003355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D8O08_003375	COG1946	Acyl-CoA thioesterase
D8O08_003380	COG1301	dicarboxylic acid transport
D8O08_003395	COG1959	2 iron, 2 sulfur cluster binding
D8O08_003400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8O08_003400	COG1017	nitric oxide dioxygenase activity
D8O08_003405	COG0433	COG0433 Predicted ATPase
D8O08_003410	COG0626	cystathionine gamma-synthase activity
D8O08_003530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D8O08_003540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D8O08_003565	COG1960	acyl-CoA dehydrogenase activity
D8O08_003570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D8O08_003600	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D8O08_003605	COG0339	signal peptide processing
D8O08_003610	COG0557	exoribonuclease II activity
D8O08_003655	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8O08_003660	COG2169	Transcriptional regulator
D8O08_003665	COG0697	spore germination
D8O08_003670	COG1295	ribonuclease BN
D8O08_003705	COG1702	phosphate starvation-inducible protein PhoH
D8O08_003715	COG0739	heme binding
D8O08_003715	COG1196	nuclear chromosome segregation
D8O08_003715	COG0741	lytic transglycosylase activity
D8O08_003745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D8O08_003750	COG1183	phosphatidylcholine synthase activity
D8O08_003795	COG1960	acyl-CoA dehydrogenase activity
D8O08_003800	COG1309	transcriptional regulator
D8O08_003815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8O08_003820	COG1960	acyl-CoA dehydrogenase activity
D8O08_003840	COG2969	positive regulation of protein catabolic process
D8O08_003850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D8O08_003865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D8O08_003870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8O08_003890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8O08_003900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8O08_003905	COG1408	metallophosphoesterase
D8O08_003915	COG2199	diguanylate cyclase activity
D8O08_003960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8O08_003960	COG3453	Protein conserved in bacteria
D8O08_003975	COG1607	acyl-coa hydrolase
D8O08_004005	COG2350	Protein conserved in bacteria
D8O08_004015	COG0613	PHP domain protein
D8O08_004020	COG3781	membrane
D8O08_004030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D8O08_004035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8O08_004045	COG1862	Preprotein translocase
D8O08_004075	COG2205	protein histidine kinase activity
D8O08_004080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D8O08_004100	COG0726	polysaccharide deacetylase
D8O08_004175	COG0625	glutathione transferase activity
D8O08_004185	COG1960	acyl-CoA dehydrogenase activity
D8O08_004190	COG1960	acyl-CoA dehydrogenase activity
D8O08_004200	COG2205	protein histidine kinase activity
D8O08_004205	COG0745	RESPONSE REGULATOR receiver
D8O08_004210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D8O08_004230	COG2096	Adenosyltransferase
D8O08_004245	COG0133	tryptophan synthase activity
D8O08_004280	COG0285	dihydrofolate synthase activity
D8O08_004300	COG0450	alkyl hydroperoxide reductase
D8O08_004315	COG0477	Major facilitator Superfamily
D8O08_004320	COG1272	protein, Hemolysin III
D8O08_004355	COG2207	Transcriptional regulator
D8O08_004375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8O08_004395	COG0183	Belongs to the thiolase family
D8O08_004405	COG2885	chlorophyll binding
D8O08_004405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D8O08_004415	COG1690	Belongs to the RtcB family
D8O08_004420	COG0833	amino acid
D8O08_004430	COG2233	PERMEase
D8O08_004460	COG2094	Belongs to the DNA glycosylase MPG family
D8O08_004465	COG4772	TonB-dependent receptor
D8O08_004480	COG1902	pentaerythritol trinitrate reductase activity
D8O08_004495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8O08_004500	COG0354	folic acid binding
D8O08_004510	COG3189	MarR family transcriptional regulator
D8O08_004515	COG2824	Alkylphosphonate utilization operon protein PhnA
D8O08_004520	COG3422	double-strand break repair
D8O08_004560	COG0840	transmembrane signaling receptor activity
D8O08_004580	COG5510	response to toxic substance
D8O08_004590	COG2832	Protein of unknown function (DUF454)
D8O08_004595	COG1376	ErfK ybiS ycfS ynhG family protein
D8O08_004645	COG1289	transmembrane transporter activity
D8O08_004650	COG2814	Major facilitator Superfamily
D8O08_004670	COG1115	amino acid carrier protein
D8O08_004675	COG1752	Esterase of the alpha-beta hydrolase superfamily
D8O08_004680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8O08_004685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D8O08_004715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8O08_004725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8O08_004730	COG1077	Cell shape determining protein MreB Mrl
D8O08_004735	COG1792	Involved in formation and maintenance of cell shape
D8O08_004740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D8O08_004745	COG0424	maF-like protein
D8O08_004750	COG1530	ribonuclease E activity
D8O08_004760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8O08_004780	COG2249	NAD(P)H dehydrogenase (quinone) activity
D8O08_004810	COG2207	Transcriptional regulator
D8O08_004830	COG1113	amino acid transport
D8O08_004835	COG2828	Protein conserved in bacteria
D8O08_004840	COG0142	geranyltranstransferase activity
D8O08_004845	COG2315	Protein conserved in bacteria
D8O08_004860	COG1752	Esterase of the alpha-beta hydrolase superfamily
D8O08_004880	COG2194	sulfuric ester hydrolase activity
D8O08_004885	COG0745	RESPONSE REGULATOR receiver
D8O08_004890	COG0642	Histidine kinase
D8O08_004900	COG0004	ammonium transporteR
D8O08_004910	COG0583	DNA-binding transcription factor activity
D8O08_004930	COG0525	valine-tRNA ligase activity
D8O08_004940	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_004950	COG0393	Putative heavy-metal-binding
D8O08_004955	COG0393	Putative heavy-metal-binding
D8O08_004960	COG1538	Outer membrane efflux protein
D8O08_004970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8O08_004975	COG0671	phosphoesterase, PA-phosphatase related
D8O08_005005	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D8O08_005020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D8O08_005020	COG1648	precorrin-2 dehydrogenase activity
D8O08_005025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D8O08_005030	COG1733	regulation of RNA biosynthetic process
D8O08_005040	COG0531	amino acid
D8O08_005055	COG0321	lipoyl(octanoyl) transferase activity
D8O08_005060	COG2921	Belongs to the UPF0250 family
D8O08_005100	COG2009	succinate dehydrogenase
D8O08_005105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D8O08_005110	COG1053	succinate dehydrogenase
D8O08_005115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D8O08_005140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8O08_005160	COG2354	Protein conserved in bacteria
D8O08_005165	COG2321	neutral zinc metallopeptidase
D8O08_005240	COG2843	Capsule synthesis protein
D8O08_005255	COG0589	response to stress
D8O08_005275	COG0505	Belongs to the CarA family
D8O08_005300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8O08_005305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D8O08_005355	COG0477	Major facilitator Superfamily
D8O08_005360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D8O08_005380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8O08_005410	COG0584	glycerophosphoryl diester phosphodiesterase
D8O08_005430	COG0741	lytic transglycosylase activity
D8O08_005455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D8O08_005470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8O08_005500	COG0778	Nitroreductase
D8O08_005515	COG1929	Belongs to the glycerate kinase type-1 family
D8O08_005520	COG0243	molybdopterin cofactor binding
D8O08_005525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D8O08_005530	COG3339	Conserved Protein
D8O08_005540	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D8O08_005555	COG1113	amino acid transport
D8O08_005565	COG0019	diaminopimelate decarboxylase activity
D8O08_005575	COG1280	lysine exporter protein (LysE YggA)
D8O08_005580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D8O08_005610	COG0463	Glycosyl transferase, family 2
D8O08_005630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8O08_005660	COG4591	ABC-type transport system involved in lipoprotein release permease component
D8O08_005665	COG1136	(ABC) transporter
D8O08_005680	COG0616	signal peptide processing
D8O08_005680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D8O08_005685	COG0596	Alpha beta hydrolase
D8O08_005690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D8O08_005700	COG0628	permease
D8O08_005735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8O08_005755	COG0823	Involved in the tonB-independent uptake of proteins
D8O08_005775	COG0824	Thioesterase
D8O08_005780	COG1473	amidohydrolase
D8O08_005800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D8O08_005800	COG0047	phosphoribosylformylglycinamidine synthase activity
D8O08_005805	COG2814	Major facilitator Superfamily
D8O08_005810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D8O08_005815	COG1024	Enoyl-CoA hydratase
D8O08_005820	COG1051	belongs to the nudix hydrolase family
D8O08_005820	COG1056	cytidyltransferase-related domain
D8O08_005830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D8O08_005845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D8O08_005860	COG4625	pathogenesis
D8O08_005865	COG0583	DNA-binding transcription factor activity
D8O08_005870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D8O08_005875	COG4208	sulfate ABC transporter
D8O08_005880	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D8O08_005890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D8O08_005895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8O08_005900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D8O08_005920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8O08_005935	COG0681	Belongs to the peptidase S26 family
D8O08_005950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D8O08_005960	COG1381	Involved in DNA repair and RecF pathway recombination
D8O08_005965	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D8O08_005975	COG4221	oxidoreductase activity
D8O08_006025	COG0556	nucleotide-excision repair
D8O08_006110	COG1215	transferase activity, transferring glycosyl groups
D8O08_006125	COG0415	Belongs to the DNA photolyase family
D8O08_006135	COG1252	NADH dehydrogenase
D8O08_006140	COG1686	Belongs to the peptidase S11 family
D8O08_006175	COG0477	Major facilitator Superfamily
D8O08_006180	COG0583	DNA-binding transcription factor activity
D8O08_006195	COG0612	Peptidase, M16
D8O08_006270	COG1309	transcriptional regulator
D8O08_006280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8O08_006285	COG0076	glutamate decarboxylase activity
D8O08_006295	COG1522	sequence-specific DNA binding
D8O08_006300	COG3961	Belongs to the TPP enzyme family
D8O08_006305	COG1113	amino acid transport
D8O08_006310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D8O08_006315	COG0573	inorganic phosphate transmembrane transporter activity
D8O08_006325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D8O08_006330	COG0616	signal peptide processing
D8O08_006365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D8O08_006370	COG1686	Belongs to the peptidase S11 family
D8O08_006395	COG0583	DNA-binding transcription factor activity
D8O08_006400	COG1067	ATP-dependent peptidase activity
D8O08_006445	COG1966	Carbon starvation protein
D8O08_006450	COG2879	small protein
D8O08_006485	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D8O08_006485	COG2508	Transcriptional regulator
D8O08_006505	COG1113	amino acid transport
D8O08_006510	COG0583	DNA-binding transcription factor activity
D8O08_006520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8O08_006535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8O08_006540	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D8O08_006540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8O08_006575	COG2814	Major facilitator Superfamily
D8O08_006580	COG4948	Mandelate Racemase Muconate Lactonizing
D8O08_006590	COG1309	transcriptional regulator
D8O08_006610	COG1741	Belongs to the pirin family
D8O08_006620	COG2964	Protein conserved in bacteria
D8O08_006635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8O08_006640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8O08_006645	COG4605	iron ion homeostasis
D8O08_006650	COG4604	ABC transporter, ATP-binding protein
D8O08_006655	COG4607	ABC-type enterochelin transport system periplasmic component
D8O08_006660	COG4774	siderophore transport
D8O08_006670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8O08_006675	COG1021	2,3-dihydroxybenzoate-AMP ligase
D8O08_006680	COG3433	isochorismatase activity
D8O08_006680	COG1535	isochorismatase
D8O08_006695	COG1132	(ABC) transporter
D8O08_006705	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D8O08_006715	COG1169	isochorismate synthase
D8O08_006730	COG3739	integral membrane protein
D8O08_006765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D8O08_006800	COG0512	Glutamine amidotransferase of anthranilate synthase
D8O08_007045	COG1598	PFAM Uncharacterised protein family UPF0150
D8O08_007075	COG0739	heme binding
D8O08_007125	COG0582	viral genome integration into host DNA
D8O08_007135	COG3104	oligopeptide transport
D8O08_007150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D8O08_007185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D8O08_007190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D8O08_007195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8O08_007220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D8O08_007225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D8O08_007240	COG1960	acyl-CoA dehydrogenase activity
D8O08_007245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D8O08_007250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8O08_007260	COG2223	nitrite transmembrane transporter activity
D8O08_007270	COG0024	Methionine aminopeptidase
D8O08_007275	COG0052	Belongs to the universal ribosomal protein uS2 family
D8O08_007290	COG2207	Transcriptional regulator
D8O08_007320	COG2951	lytic endotransglycosylase activity
D8O08_007325	COG0772	Belongs to the SEDS family
D8O08_007340	COG0842	Transport permease protein
D8O08_007345	COG1131	(ABC) transporter
D8O08_007380	COG1538	Outer membrane efflux protein
D8O08_007390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8O08_007405	COG4215	(ABC) transporter
D8O08_007410	COG4160	amino acid transport
D8O08_007415	COG4598	ABC transporter
D8O08_007425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8O08_007450	COG1720	tRNA m6t6A37 methyltransferase activity
D8O08_007470	COG0745	RESPONSE REGULATOR receiver
D8O08_007475	COG0642	Histidine kinase
D8O08_007485	COG0494	nUDIX hydrolase
D8O08_007495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8O08_007500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D8O08_007505	COG3139	Protein of unknown function (DUF1315)
D8O08_007510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D8O08_007520	COG1301	dicarboxylic acid transport
D8O08_007525	COG1960	acyl-CoA dehydrogenase activity
D8O08_007530	COG2819	hydrolase of the alpha beta superfamily
D8O08_007540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D8O08_007550	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8O08_007555	COG1234	tRNA 3'-trailer cleavage
D8O08_007585	COG2363	Small membrane protein
D8O08_007605	COG0513	Belongs to the DEAD box helicase family
D8O08_007615	COG0778	Nitroreductase
D8O08_007645	COG1286	toxin biosynthetic process
D8O08_007670	COG4783	chaperone-mediated protein folding
D8O08_007675	COG1610	YqeY-like protein
D8O08_007680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D8O08_007775	COG3111	PFAM Bacterial OB fold (BOF) protein
D8O08_007800	COG3243	poly(R)-hydroxyalkanoic acid synthase
D8O08_007805	COG0786	glutamate:sodium symporter activity
D8O08_007815	COG2186	Transcriptional regulator
D8O08_007865	COG0477	Major facilitator Superfamily
D8O08_007895	COG2985	domain, Protein
D8O08_007905	COG2995	paraquat-inducible protein a
D8O08_007910	COG3008	intermembrane lipid transfer
D8O08_007910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D8O08_008005	COG1113	amino acid transport
D8O08_008015	COG0531	amino acid
D8O08_008035	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_008055	COG1113	amino acid transport
D8O08_008060	COG3316	Transposase and inactivated derivatives
D8O08_008065	COG0300	oxidoreductase activity
D8O08_008075	COG1309	transcriptional regulator
D8O08_008080	COG1741	Belongs to the pirin family
D8O08_008095	COG2072	flavoprotein involved in K transport
D8O08_008105	COG2252	PERMEase
D8O08_008110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D8O08_008115	COG3038	cytochrome b561
D8O08_008125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D8O08_008145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D8O08_008155	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D8O08_008170	COG0667	Aldo Keto reductase
D8O08_008185	COG1765	OsmC-like protein
D8O08_008235	COG2885	chlorophyll binding
D8O08_008245	COG0625	glutathione transferase activity
D8O08_008250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D8O08_008270	COG3634	alkyl hydroperoxide reductase activity
D8O08_008285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D8O08_008295	COG0450	alkyl hydroperoxide reductase
D8O08_008300	COG1643	Atp-dependent helicase
D8O08_008315	COG2814	Major facilitator Superfamily
D8O08_008320	COG3135	benzoate transporter
D8O08_008325	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_008330	COG0633	Ferredoxin
D8O08_008330	COG0543	2 iron, 2 sulfur cluster binding
D8O08_008335	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D8O08_008340	COG4638	Rieske (2fe-2S)
D8O08_008345	COG0583	DNA-binding transcription factor activity
D8O08_008400	COG1570	exodeoxyribonuclease VII activity
D8O08_008435	COG1280	lysine exporter protein (LysE YggA)
D8O08_008440	COG1278	Cold shock
D8O08_008480	COG2814	Major facilitator Superfamily
D8O08_008485	COG1733	regulation of RNA biosynthetic process
D8O08_008520	COG0517	IMP dehydrogenase activity
D8O08_008520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D8O08_008525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D8O08_008535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D8O08_008540	COG1137	ATPase activity
D8O08_008545	COG1538	Outer membrane efflux protein
D8O08_008585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D8O08_008600	COG1522	sequence-specific DNA binding
D8O08_008605	COG5006	permease, DMT superfamily
D8O08_008615	COG1560	Kdo2-lipid A biosynthetic process
D8O08_008650	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8O08_008685	COG3501	Rhs element vgr protein
D8O08_008690	COG3209	COG3209 Rhs family protein
D8O08_008705	COG0583	DNA-binding transcription factor activity
D8O08_008710	COG1914	H( )-stimulated, divalent metal cation uptake system
D8O08_008730	COG4770	biotin carboxylase activity
D8O08_008735	COG0038	chloride channel
D8O08_008760	COG1309	transcriptional regulator
D8O08_008770	COG1063	alcohol dehydrogenase
D8O08_008790	COG2249	NAD(P)H dehydrogenase (quinone) activity
D8O08_008810	COG0864	Transcriptional regulator
D8O08_008820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8O08_008825	COG1116	anion transmembrane transporter activity
D8O08_008895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D8O08_008895	COG2885	chlorophyll binding
D8O08_008935	COG0583	DNA-binding transcription factor activity
D8O08_008945	COG0590	tRNA wobble adenosine to inosine editing
D8O08_008950	COG2807	transmembrane transport
D8O08_008965	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8O08_008980	COG0789	Transcriptional regulator
D8O08_008995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8O08_009015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8O08_009025	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8O08_009040	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_009045	COG0531	amino acid
D8O08_009050	COG1760	l-serine dehydratase
D8O08_009055	COG2030	dehydratase
D8O08_009055	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_009060	COG3396	Phenylacetate-CoA oxygenase
D8O08_009065	COG3460	Phenylacetate-CoA oxygenase
D8O08_009070	COG3396	Phenylacetate-CoA oxygenase
D8O08_009075	COG2151	metal-sulfur cluster biosynthetic enzyme
D8O08_009080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8O08_009085	COG1024	Enoyl-CoA hydratase
D8O08_009090	COG1024	Enoyl-CoA hydratase
D8O08_009095	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8O08_009100	COG0183	Belongs to the thiolase family
D8O08_009105	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D8O08_009110	COG3327	negative regulation of DNA-templated transcription, initiation
D8O08_009120	COG2050	protein possibly involved in aromatic compounds catabolism
D8O08_009160	COG0753	catalase activity
D8O08_009165	COG3038	cytochrome b561
D8O08_009185	COG2267	carboxylic ester hydrolase activity
D8O08_009190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8O08_009200	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_009210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D8O08_009225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8O08_009230	COG0583	DNA-binding transcription factor activity
D8O08_009240	COG1414	Transcriptional regulator
D8O08_009245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8O08_009255	COG1840	ABC-type Fe3 transport system, periplasmic component
D8O08_009260	COG3842	ATPase activity
D8O08_009275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D8O08_009280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8O08_009285	COG2814	Major facilitator Superfamily
D8O08_009290	COG1960	acyl-CoA dehydrogenase activity
D8O08_009305	COG1024	Enoyl-CoA hydratase
D8O08_009315	COG2814	Major facilitator Superfamily
D8O08_009325	COG0183	Belongs to the thiolase family
D8O08_009330	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8O08_009335	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_009340	COG1024	Enoyl-CoA hydratase
D8O08_009345	COG1960	acyl-CoA dehydrogenase activity
D8O08_009350	COG2814	Major facilitator Superfamily
D8O08_009355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D8O08_009360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8O08_009370	COG2814	Major facilitator Superfamily
D8O08_009380	COG1960	acyl-CoA dehydrogenase activity
D8O08_009395	COG0583	DNA-binding transcription factor activity
D8O08_009410	COG1024	Enoyl-CoA hydratase
D8O08_009415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8O08_009420	COG1960	acyl-CoA dehydrogenase activity
D8O08_009425	COG1309	transcriptional regulator
D8O08_009430	COG0318	PFAM AMP-dependent synthetase and ligase
D8O08_009450	COG0583	DNA-binding transcription factor activity
D8O08_009495	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_009515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D8O08_009535	COG2205	protein histidine kinase activity
D8O08_009535	COG0784	Response regulator, receiver
D8O08_009565	COG0765	amino acid transport
D8O08_009570	COG0765	amino acid transport
D8O08_009575	COG1126	abc transporter atp-binding protein
D8O08_009580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8O08_009585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8O08_009600	COG1280	lysine exporter protein (LysE YggA)
D8O08_009605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8O08_009610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8O08_009615	COG1045	serine acetyltransferase
D8O08_009630	COG0583	DNA-binding transcription factor activity
D8O08_009635	COG0625	glutathione transferase activity
D8O08_009640	COG0625	glutathione transferase activity
D8O08_009645	COG0583	DNA-binding transcription factor activity
D8O08_009655	COG1346	cytolysis
D8O08_009675	COG2814	Major facilitator Superfamily
D8O08_009685	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D8O08_009690	COG3052	prosthetic group binding
D8O08_009710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D8O08_009730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8O08_009740	COG1294	oxidase, subunit
D8O08_009745	COG1271	oxidase subunit
D8O08_009770	COG0477	Major facilitator Superfamily
D8O08_009780	COG4521	taurine ABC transporter
D8O08_009785	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8O08_009790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8O08_009805	COG1953	Uracil, thiamine, allantoin
D8O08_009815	COG0583	DNA-binding transcription factor activity
D8O08_009825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D8O08_009840	COG0640	Transcriptional regulator
D8O08_009845	COG0798	PFAM Bile acid sodium symporter
D8O08_009855	COG0583	DNA-binding transcription factor activity
D8O08_009870	COG3634	alkyl hydroperoxide reductase activity
D8O08_009910	COG0436	Aminotransferase
D8O08_009920	COG0386	Belongs to the glutathione peroxidase family
D8O08_009960	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D8O08_009985	COG0012	GTP binding
D8O08_009990	COG2011	ABC-type metal ion transport system permease component
D8O08_009995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D8O08_010005	COG1464	Belongs to the NlpA lipoprotein family
D8O08_010035	COG0765	amino acid transport
D8O08_010040	COG0765	amino acid transport
D8O08_010045	COG1126	abc transporter atp-binding protein
D8O08_010055	COG1522	sequence-specific DNA binding
D8O08_010070	COG1309	transcriptional regulator
D8O08_010090	COG0583	DNA-binding transcription factor activity
D8O08_010100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D8O08_010110	COG0697	spore germination
D8O08_010140	COG3121	Chaperone
D8O08_010145	COG3539	Fimbrial protein
D8O08_010175	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D8O08_010175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D8O08_010220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D8O08_010230	COG2353	YceI-like domain
D8O08_010240	COG3698	Phosphodiester glycosidase
D8O08_010255	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D8O08_010260	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D8O08_010260	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D8O08_010260	COG0506	proline dehydrogenase activity
D8O08_010270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8O08_010275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D8O08_010295	COG1132	(ABC) transporter
D8O08_010305	COG3619	membrane
D8O08_010315	COG0640	Transcriptional regulator
D8O08_010325	COG2850	peptidyl-arginine hydroxylation
D8O08_010330	COG0424	maF-like protein
D8O08_010350	COG0191	fructose-bisphosphate aldolase activity
D8O08_010355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8O08_010370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D8O08_010380	COG1192	Involved in chromosome partitioning
D8O08_010385	COG1475	DNA binding
D8O08_010390	COG0811	peptide transport
D8O08_010400	COG1132	(ABC) transporter
D8O08_010405	COG1663	tetraacyldisaccharide 4'-kinase activity
D8O08_010425	COG0084	hydrolase, TatD family'
D8O08_010440	COG2165	general secretion pathway protein
D8O08_010490	COG0776	regulation of translation
D8O08_010520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D8O08_010580	COG0305	Participates in initiation and elongation during chromosome replication
D8O08_010670	COG4695	Portal protein
D8O08_010725	COG0741	lytic transglycosylase activity
D8O08_010725	COG0739	heme binding
D8O08_010725	COG1196	nuclear chromosome segregation
D8O08_010795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D8O08_010845	COG0339	signal peptide processing
D8O08_010855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8O08_010890	COG0702	epimerase
D8O08_010895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D8O08_010915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8O08_010945	COG0316	Belongs to the HesB IscA family
D8O08_010950	COG0822	iron-sulfur transferase activity
D8O08_010975	COG0776	regulation of translation
D8O08_010980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8O08_010985	COG2207	Transcriptional regulator
D8O08_010990	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8O08_010995	COG1960	acyl-CoA dehydrogenase activity
D8O08_011000	COG1960	acyl-CoA dehydrogenase activity
D8O08_011035	COG4264	IucA IucC family
D8O08_011100	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D8O08_011120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D8O08_011125	COG0730	response to heat
D8O08_011145	COG4773	Receptor
D8O08_011150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8O08_011165	COG1131	(ABC) transporter
D8O08_011170	COG0842	Transport permease protein
D8O08_011175	COG0842	Transport permease protein
D8O08_011230	COG2226	methyltransferase
D8O08_011255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D8O08_011290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8O08_011300	COG0133	tryptophan synthase activity
D8O08_011315	COG3706	GGDEF domain
D8O08_011330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D8O08_011335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8O08_011340	COG0022	dehydrogenase e1 component
D8O08_011345	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8O08_011350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8O08_011360	COG1063	alcohol dehydrogenase
D8O08_011365	COG3781	membrane
D8O08_011375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8O08_011375	COG3453	Protein conserved in bacteria
D8O08_011385	COG0730	response to heat
D8O08_011400	COG2207	Transcriptional regulator
D8O08_011400	COG3708	Transcriptional regulator
D8O08_011405	COG1733	regulation of RNA biosynthetic process
D8O08_011410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D8O08_011435	COG4521	taurine ABC transporter
D8O08_011440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8O08_011460	COG0477	Major facilitator Superfamily
D8O08_011470	COG1027	Aspartate ammonia-lyase
D8O08_011485	COG0583	DNA-binding transcription factor activity
D8O08_011495	COG0183	Belongs to the thiolase family
D8O08_011505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8O08_011515	COG0583	DNA-binding transcription factor activity
D8O08_011525	COG2610	gluconate transmembrane transporter activity
D8O08_011530	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_011540	COG2207	Transcriptional regulator
D8O08_011550	COG0412	Dienelactone hydrolase
D8O08_011555	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_011565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8O08_011580	COG0543	2 iron, 2 sulfur cluster binding
D8O08_011580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8O08_011585	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D8O08_011590	COG4638	Rieske (2fe-2S)
D8O08_011600	COG0725	ABC transporter, periplasmic molybdate-binding protein
D8O08_011605	COG4149	molybdate abc transporter
D8O08_011610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D8O08_011615	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_011685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8O08_011700	COG0753	catalase activity
D8O08_011710	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D8O08_011740	COG3539	Fimbrial protein
D8O08_011760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8O08_011780	COG2072	flavoprotein involved in K transport
D8O08_011790	COG1538	Outer membrane efflux protein
D8O08_011795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8O08_011800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8O08_011805	COG0745	RESPONSE REGULATOR receiver
D8O08_011810	COG2205	protein histidine kinase activity
D8O08_011820	COG2207	Transcriptional regulator
D8O08_011835	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_011890	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D8O08_012025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D8O08_012045	COG1120	ATPase activity
D8O08_012060	COG1064	alcohol dehydrogenase
D8O08_012075	COG2207	Transcriptional regulator
D8O08_012080	COG2084	Dehydrogenase
D8O08_012090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8O08_012095	COG0583	DNA-binding transcription factor activity
D8O08_012105	COG0129	dihydroxy-acid dehydratase activity
D8O08_012110	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_012125	COG1566	PFAM secretion protein HlyD family protein
D8O08_012150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8O08_012175	COG0583	DNA-binding transcription factor activity
D8O08_012240	COG1473	amidohydrolase
D8O08_012250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8O08_012250	COG0475	glutathione-regulated potassium exporter activity
D8O08_012265	COG1335	isochorismatase
D8O08_012275	COG1309	transcriptional regulator
D8O08_012305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D8O08_012315	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8O08_012315	COG1902	pentaerythritol trinitrate reductase activity
D8O08_012320	COG1846	Transcriptional regulator
D8O08_012345	COG0753	catalase activity
D8O08_012360	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_012375	COG3162	membrane
D8O08_012385	COG3829	transcription factor binding
D8O08_012390	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_012395	COG1960	acyl-CoA dehydrogenase activity
D8O08_012415	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_012435	COG2186	Transcriptional regulator
D8O08_012445	COG0583	DNA-binding transcription factor activity
D8O08_012450	COG4948	Mandelate Racemase Muconate Lactonizing
D8O08_012455	COG4829	muconolactone delta-isomerase
D8O08_012465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D8O08_012470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8O08_012475	COG0183	Belongs to the thiolase family
D8O08_012480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8O08_012490	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_012500	COG3733	amine oxidase
D8O08_012510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8O08_012520	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_012530	COG4638	Rieske (2fe-2S)
D8O08_012550	COG0154	amidase activity
D8O08_012560	COG2814	Major facilitator Superfamily
D8O08_012585	COG1960	acyl-CoA dehydrogenase activity
D8O08_012590	COG0583	DNA-binding transcription factor activity
D8O08_012595	COG1414	Transcriptional regulator
D8O08_012610	COG2391	methyltransferase activity
D8O08_012620	COG4993	Dehydrogenase
D8O08_012625	COG3659	wide pore channel activity
D8O08_012635	COG0710	3-dehydroquinate dehydratase activity
D8O08_012640	COG3485	protocatechuate 3,4-dioxygenase
D8O08_012645	COG3485	protocatechuate 3,4-dioxygenase
D8O08_012650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8O08_012655	COG2271	Major facilitator Superfamily
D8O08_012660	COG0596	Alpha beta hydrolase
D8O08_012665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D8O08_012670	COG0183	Belongs to the thiolase family
D8O08_012675	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8O08_012680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D8O08_012690	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D8O08_012695	COG2323	membrane
D8O08_012740	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8O08_012740	COG1902	pentaerythritol trinitrate reductase activity
D8O08_012755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D8O08_012765	COG0542	response to heat
D8O08_012770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D8O08_012800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8O08_012805	COG0569	domain protein
D8O08_012810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8O08_012825	COG4774	siderophore transport
D8O08_012830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D8O08_012840	COG1585	Membrane protein implicated in regulation of membrane protease activity
D8O08_012865	COG1294	oxidase, subunit
D8O08_012870	COG4890	Cyd operon protein YbgT
D8O08_012885	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D8O08_012895	COG0552	protein localization to endoplasmic reticulum
D8O08_012920	COG0517	IMP dehydrogenase activity
D8O08_012920	COG0516	GMP reductase activity
D8O08_012925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8O08_012930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D8O08_012940	COG0583	DNA-binding transcription factor activity
D8O08_012945	COG0024	Methionine aminopeptidase
D8O08_012975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8O08_012975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D8O08_012985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8O08_012985	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D8O08_012985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8O08_013005	COG3300	MHYT domain
D8O08_013005	COG5001	Diguanylate cyclase
D8O08_013020	COG2135	peptidase activity
D8O08_013025	COG0659	secondary active sulfate transmembrane transporter activity
D8O08_013040	COG1113	amino acid transport
D8O08_013050	COG1522	sequence-specific DNA binding
D8O08_013075	COG1011	Hydrolase
D8O08_013080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D8O08_013090	COG2137	regulation of response to DNA damage stimulus
D8O08_013105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8O08_013140	COG0575	Belongs to the CDS family
D8O08_013145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D8O08_013170	COG3852	Histidine kinase
D8O08_013175	COG2204	response regulator
D8O08_013235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8O08_013240	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D8O08_013260	COG0697	spore germination
D8O08_013265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8O08_013275	COG0303	'Molybdopterin
D8O08_013280	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8O08_013280	COG0315	cyclic pyranopterin monophosphate synthase activity
D8O08_013295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D8O08_013300	COG0243	molybdopterin cofactor binding
D8O08_013310	COG0243	molybdopterin cofactor binding
D8O08_013315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8O08_013320	COG2146	nitrite reductase [NAD(P)H] activity
D8O08_013320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8O08_013330	COG0745	RESPONSE REGULATOR receiver
D8O08_013335	COG1116	anion transmembrane transporter activity
D8O08_013335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8O08_013355	COG0511	ligase activity, forming carbon-carbon bonds
D8O08_013370	COG2814	Major facilitator Superfamily
D8O08_013390	COG0069	glutamate synthase activity
D8O08_013420	COG1454	alcohol dehydrogenase
D8O08_013425	COG0824	Thioesterase
D8O08_013435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8O08_013465	COG0183	Belongs to the thiolase family
D8O08_013475	COG0583	DNA-binding transcription factor activity
D8O08_013490	COG1522	sequence-specific DNA binding
D8O08_013495	COG3135	benzoate transporter
D8O08_013505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D8O08_013520	COG0589	response to stress
D8O08_013525	COG0488	(ABC) transporter
D8O08_013545	COG4773	Receptor
D8O08_013580	COG0668	transmembrane transport
D8O08_013590	COG1309	transcriptional regulator
D8O08_013610	COG1605	Chorismate mutase
D8O08_013620	COG4221	oxidoreductase activity
D8O08_013630	COG0308	aminopeptidase N
D8O08_013650	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D8O08_013665	COG1454	alcohol dehydrogenase
D8O08_013690	COG4303	Ethanolamine ammonia lyase large subunit
D8O08_013695	COG4302	ethanolamine ammonia-lyase activity
D8O08_013700	COG0519	Catalyzes the synthesis of GMP from XMP
D8O08_013700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8O08_013715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8O08_013730	COG0697	spore germination
D8O08_013735	COG1923	regulation of RNA biosynthetic process
D8O08_013745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D8O08_013750	COG0802	atpase or kinase
D8O08_013770	COG1187	pseudouridine synthase activity
D8O08_013785	COG0583	DNA-binding transcription factor activity
D8O08_013805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8O08_013835	COG0729	surface antigen
D8O08_013855	COG0174	glutamine synthetase
D8O08_013860	COG0745	RESPONSE REGULATOR receiver
D8O08_013865	COG2205	protein histidine kinase activity
D8O08_013875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D8O08_013880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D8O08_013905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8O08_013910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8O08_013915	COG1960	acyl-CoA dehydrogenase activity
D8O08_013930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8O08_013935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8O08_013960	COG0583	DNA-binding transcription factor activity
D8O08_013980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8O08_013990	COG3658	cytochrome
D8O08_013995	COG1215	transferase activity, transferring glycosyl groups
D8O08_014000	COG0726	polysaccharide deacetylase
D8O08_014000	COG1649	PFAM Uncharacterised BCR, COG1649
D8O08_014025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D8O08_014030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8O08_014040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D8O08_014070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8O08_014080	COG1305	Transglutaminase-like
D8O08_014090	COG2308	Evidence 4 Homologs of previously reported genes of
D8O08_014120	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D8O08_014125	COG0138	bifunctional purine biosynthesis protein purh
D8O08_014130	COG0151	Belongs to the GarS family
D8O08_014135	COG1464	Belongs to the NlpA lipoprotein family
D8O08_014140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D8O08_014145	COG2011	ABC-type metal ion transport system permease component
D8O08_014150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8O08_014160	COG1301	dicarboxylic acid transport
D8O08_014180	COG3316	Transposase and inactivated derivatives
D8O08_014205	COG2433	Pfam Transposase IS66
D8O08_014215	COG3173	Aminoglycoside phosphotransferase
D8O08_014235	COG0482	sulfurtransferase activity
D8O08_014315	COG3501	Rhs element vgr protein
D8O08_014335	COG4269	membrane
D8O08_014350	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8O08_014350	COG1902	pentaerythritol trinitrate reductase activity
D8O08_014370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8O08_014390	COG4172	Belongs to the ABC transporter superfamily
D8O08_014395	COG4239	(ABC) transporter, permease
D8O08_014400	COG4174	ABC transporter (Permease)
D8O08_014410	COG0741	lytic transglycosylase activity
D8O08_014410	COG0741	lytic transglycosylase activity
D8O08_014410	COG1388	LysM domain
D8O08_014410	COG1388	LysM domain
D8O08_014415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8O08_014455	COG0583	DNA-binding transcription factor activity
D8O08_014460	COG1279	arginine transmembrane transporter activity
D8O08_014480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8O08_014485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8O08_014490	COG0006	proline dipeptidase activity
D8O08_014525	COG2194	sulfuric ester hydrolase activity
D8O08_014570	COG0739	heme binding
D8O08_015025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8O08_015090	COG1061	Type III restriction enzyme res subunit
D8O08_015160	COG3316	Transposase and inactivated derivatives
D8O08_015175	COG3173	Aminoglycoside phosphotransferase
D8O08_015195	COG0482	sulfurtransferase activity
D8O08_015255	COG3316	Transposase and inactivated derivatives
D8O08_015320	COG1192	Involved in chromosome partitioning
D8O08_015340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8O08_015375	COG0606	chelatase, subunit chli
D8O08_015385	COG0347	Belongs to the P(II) protein family
D8O08_015390	COG0004	ammonium transporteR
D8O08_015400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8O08_015400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8O08_015440	COG0795	lipopolysaccharide-transporting ATPase activity
D8O08_015445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D8O08_015450	COG0793	Belongs to the peptidase S41A family
D8O08_015465	COG2197	response regulator
D8O08_015475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D8O08_015485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8O08_015490	COG4974	Belongs to the 'phage' integrase family
D8O08_015515	COG0772	Belongs to the SEDS family
D8O08_015520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8O08_015525	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D8O08_015530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8O08_015555	COG0697	spore germination
D8O08_015560	COG1538	Outer membrane efflux protein
D8O08_015580	COG3275	phosphorelay sensor kinase activity
D8O08_015590	COG0181	hydroxymethylbilane synthase activity
D8O08_015635	COG1716	ATPase activity
D8O08_015640	COG0546	phosphoglycolate phosphatase activity
D8O08_015735	COG0596	Alpha beta hydrolase
D8O08_015740	COG2056	Na+-H+ antiporter family
D8O08_015755	COG0326	Molecular chaperone. Has ATPase activity
D8O08_015770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D8O08_015840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D8O08_015845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8O08_015845	COG2169	Transcriptional regulator
D8O08_015875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D8O08_015885	COG0497	DNA recombination
D8O08_015900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8O08_015910	COG0237	dephospho-CoA kinase activity
D8O08_015960	COG0195	Participates in both transcription termination and antitermination
D8O08_015980	COG2212	antiporter activity
D8O08_015990	COG0651	ATP synthesis coupled electron transport
D8O08_015995	COG1006	Multisubunit Na H antiporter MnhC subunit
D8O08_016000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8O08_016000	COG2111	Na H antiporter
D8O08_016020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8O08_016035	COG2226	methyltransferase
D8O08_016055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D8O08_016060	COG1074	ATP-dependent DNA helicase activity
D8O08_016065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D8O08_016085	COG0598	Magnesium transport protein CorA
D8O08_016090	COG0789	Transcriptional regulator
D8O08_016095	COG0484	heat shock protein binding
D8O08_016105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D8O08_016110	COG0475	glutathione-regulated potassium exporter activity
D8O08_016110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8O08_016115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8O08_016135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8O08_016145	COG4535	Mg2 and Co2 transporter CorC
D8O08_016150	COG0425	Belongs to the sulfur carrier protein TusA family
D8O08_016155	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
D8O08_016155	COG0644	oxidoreductase
D8O08_016165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D8O08_016180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8O08_016185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D8O08_016225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D8O08_016240	COG0534	Mate efflux family protein
D8O08_016250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8O08_016255	COG4221	oxidoreductase activity
D8O08_016260	COG0583	DNA-binding transcription factor activity
D8O08_016280	COG1530	ribonuclease E activity
D8O08_016295	COG0546	phosphoglycolate phosphatase activity
D8O08_016300	COG2378	regulation of single-species biofilm formation
D8O08_016305	COG0625	glutathione transferase activity
D8O08_016315	COG0583	DNA-binding transcription factor activity
D8O08_016380	COG0473	3-isopropylmalate dehydrogenase activity
D8O08_016435	COG1301	dicarboxylic acid transport
D8O08_016445	COG1560	Kdo2-lipid A biosynthetic process
D8O08_016450	COG1280	lysine exporter protein (LysE YggA)
D8O08_016470	COG1733	regulation of RNA biosynthetic process
D8O08_016495	COG0210	DNA helicase
D8O08_016500	COG0724	RNA recognition motif
D8O08_016520	COG4651	solute:proton antiporter activity
D8O08_016520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8O08_016525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D8O08_016530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D8O08_016545	COG0788	formyltetrahydrofolate deformylase activity
D8O08_016645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8O08_016645	COG2813	Specifically methylates the guanine in position
D8O08_016655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8O08_016675	COG0740	serine-type endopeptidase activity
D8O08_016695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D8O08_016695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D8O08_016700	COG0280	phosphate acetyltransferase
D8O08_016700	COG0857	belongs to the CobB CobQ family
D8O08_016705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D8O08_016715	COG0800	Aldolase
D8O08_016725	COG3265	gluconokinase activity
D8O08_016730	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_016740	COG2267	carboxylic ester hydrolase activity
D8O08_016755	COG0793	Belongs to the peptidase S41A family
D8O08_016790	COG1426	Protein conserved in bacteria
D8O08_016830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8O08_016835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8O08_016845	COG0318	PFAM AMP-dependent synthetase and ligase
D8O08_016860	COG2986	histidine ammonia-lyase
D8O08_016900	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_016905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8O08_016925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D8O08_016935	COG1162	GTPase activity
D8O08_016940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D8O08_016955	COG1538	Outer membrane efflux protein
D8O08_016960	COG1136	(ABC) transporter
D8O08_016960	COG0577	efflux transmembrane transporter activity
D8O08_016965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8O08_016990	COG0028	Belongs to the TPP enzyme family
D8O08_016995	COG0440	acetolactate synthase activity
D8O08_017030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D8O08_017045	COG0084	hydrolase, TatD family'
D8O08_017060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8O08_017070	COG0583	DNA-binding transcription factor activity
D8O08_017080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D8O08_017085	COG2814	Major facilitator Superfamily
D8O08_017095	COG0697	spore germination
D8O08_017100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D8O08_017105	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D8O08_017110	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D8O08_017125	COG3622	Belongs to the hyi family
D8O08_017130	COG2084	Dehydrogenase
D8O08_017135	COG1024	Enoyl-CoA hydratase
D8O08_017140	COG0784	Response regulator, receiver
D8O08_017140	COG2205	protein histidine kinase activity
D8O08_017140	COG5002	protein histidine kinase activity
D8O08_017160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8O08_017170	COG3956	TIGRFAM MazG family protein
D8O08_017175	COG1555	photosystem II stabilization
D8O08_017180	COG0617	tRNA 3'-terminal CCA addition
D8O08_017185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D8O08_017205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8O08_017210	COG3028	Belongs to the UPF0307 family
D8O08_017215	COG0318	PFAM AMP-dependent synthetase and ligase
D8O08_017235	COG0625	glutathione transferase activity
D8O08_017240	COG1238	metal cluster binding
D8O08_017255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D8O08_017280	COG0072	phenylalanine-tRNA ligase activity
D8O08_017310	COG0248	Ppx GppA phosphatase
D8O08_017320	COG0037	tRNA processing
D8O08_017360	COG1764	response to oxidative stress
D8O08_017365	COG1846	Transcriptional regulator
D8O08_017375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D8O08_017435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D8O08_017440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D8O08_017445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D8O08_017505	COG1214	PFAM Peptidase M22, glycoprotease
D8O08_017530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D8O08_017535	COG0561	phosphatase activity
D8O08_017545	COG2132	Multicopper oxidase
D8O08_017550	COG3667	copper resistance
D8O08_017565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8O08_017570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D8O08_017575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D8O08_017605	COG1063	alcohol dehydrogenase
D8O08_017615	COG1960	acyl-CoA dehydrogenase activity
D8O08_017620	COG2814	Major facilitator Superfamily
D8O08_017625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8O08_017640	COG0583	DNA-binding transcription factor activity
D8O08_017660	COG0583	DNA-binding transcription factor activity
D8O08_017670	COG1473	amidohydrolase
D8O08_017690	COG0583	DNA-binding transcription factor activity
D8O08_017700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D8O08_017705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8O08_017735	COG0384	phenazine biosynthesis protein PhzF
D8O08_017755	COG4993	Dehydrogenase
D8O08_017835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8O08_017855	COG0745	RESPONSE REGULATOR receiver
D8O08_017860	COG2205	protein histidine kinase activity
D8O08_017895	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D8O08_017930	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8O08_017950	COG0583	DNA-binding transcription factor activity
D8O08_017980	COG2081	HI0933 family
D8O08_017985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D8O08_018015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8O08_018015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8O08_018025	COG0489	protein tyrosine kinase activity
D8O08_018085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D8O08_018095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8O08_018110	COG0730	response to heat
D8O08_018120	COG1196	nuclear chromosome segregation
D8O08_018140	COG2223	nitrite transmembrane transporter activity
D8O08_018145	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D8O08_018150	COG1877	trehalose-phosphatase activity
D8O08_018170	COG4106	trans-aconitate 2-methyltransferase activity
D8O08_018185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D8O08_018190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D8O08_018195	COG0009	L-threonylcarbamoyladenylate synthase
D8O08_018200	COG3101	peptidyl-lysine hydroxylation
D8O08_018205	COG1399	metal-binding, possibly nucleic acid-binding protein
D8O08_018230	COG1652	LysM domain
D8O08_018235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D8O08_018235	COG0352	thiamine-phosphate diphosphorylase activity
D8O08_018235	COG0351	phosphomethylpyrimidine kinase
D8O08_018275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D8O08_018305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D8O08_018320	COG0358	DNA primase activity
D8O08_018330	COG0564	pseudouridine synthase activity
D8O08_018355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8O08_018375	COG0583	DNA-binding transcription factor activity
D8O08_018380	COG0473	3-isopropylmalate dehydrogenase activity
D8O08_018400	COG1012	belongs to the aldehyde dehydrogenase family
D8O08_018420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D8O08_018420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D8O08_018480	COG0456	acetyltransferase
D8O08_018490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D8O08_018495	COG0492	ferredoxin-NADP+ reductase activity
D8O08_018500	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D8O08_018500	COG1674	ftsk spoiiie
D8O08_018505	COG1280	lysine exporter protein (LysE YggA)
D8O08_018525	COG2894	cell division
D8O08_018540	COG0204	Acyl-transferase
D8O08_018545	COG2885	chlorophyll binding
D8O08_018550	COG0210	DNA helicase
D8O08_018560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8O08_018575	COG0121	glutamine amidotransferase
D8O08_018600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8O08_018605	COG0735	belongs to the Fur family
D8O08_018630	COG0420	3'-5' exonuclease activity
D8O08_018650	COG1090	epimerase
D8O08_018665	COG2050	protein possibly involved in aromatic compounds catabolism
D8O08_018675	COG2814	Major facilitator Superfamily
D8O08_018680	COG0405	Gamma-glutamyltransferase
D8O08_018745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8O08_018835	COG1484	DNA-dependent DNA replication
D8O08_018885	COG3755	Protein conserved in bacteria
D8O08_019035	COG2026	Addiction module toxin, RelE StbE family
D8O08_019075	COG0592	DNA-directed DNA polymerase activity
D8O08_019175	COG0084	hydrolase, TatD family'
D8O08_019195	COG0477	Major facilitator Superfamily
D8O08_019200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8O08_019210	COG1595	DNA-templated transcription, initiation
D8O08_019265	COG0531	amino acid
D8O08_019270	COG2040	homocysteine
D8O08_019295	COG1309	transcriptional regulator
D8O08_019300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8O08_019305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8O08_019315	COG1607	acyl-coa hydrolase
D8O08_019325	COG0523	cobalamin synthesis protein
D8O08_019335	COG4681	YaeQ
D8O08_019345	COG1649	PFAM Uncharacterised BCR, COG1649
D8O08_019345	COG0726	polysaccharide deacetylase
D8O08_019350	COG1215	transferase activity, transferring glycosyl groups
D8O08_019360	COG1024	Enoyl-CoA hydratase
D8O08_019375	COG1414	Transcriptional regulator
D8O08_019395	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_019405	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8O08_019410	COG2271	Major facilitator Superfamily
D8O08_019420	COG2267	carboxylic ester hydrolase activity
D8O08_019425	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_019440	COG0028	Belongs to the TPP enzyme family
D8O08_019450	COG0477	Major facilitator Superfamily
D8O08_019455	COG0242	peptide deformylase activity
D8O08_019460	COG2066	Belongs to the glutaminase family
D8O08_019465	COG2207	Transcriptional regulator
D8O08_019470	COG2223	nitrite transmembrane transporter activity
D8O08_019490	COG0583	DNA-binding transcription factor activity
D8O08_019495	COG1028	Short-chain dehydrogenase reductase Sdr
D8O08_019500	COG2271	Major facilitator Superfamily
D8O08_019505	COG3959	Transketolase, thiamine diphosphate binding domain
D8O08_019510	COG3958	Transketolase
D8O08_019520	COG0306	phosphate transporter
D8O08_019540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D8O08_019585	COG4181	ATPase activity
D8O08_019590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D8O08_019615	COG0583	DNA-binding transcription factor activity
D8O08_019625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8O08_019630	COG1773	rubredoxin
D8O08_019690	COG1253	flavin adenine dinucleotide binding
D8O08_019740	COG0830	nickel cation binding
D8O08_019755	COG0742	ribosomal rna small subunit methyltransferase
D8O08_019760	COG0768	penicillin binding
D8O08_019785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D8O08_019790	COG2878	Part of a membrane complex involved in electron transport
D8O08_019795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8O08_019805	COG3384	dioxygenase
D8O08_019830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D8O08_020060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D8O08_020170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8O08_020300	COG4683	PFAM Phage derived protein Gp49-like (DUF891)