locus-tag	class	description
HBM78_00010	COG0592	DNA-directed DNA polymerase activity
HBM78_00020	COG0187	DNA topoisomerase II activity
HBM78_00030	COG0586	Pfam SNARE associated Golgi protein
HBM78_00035	COG0488	(ABC) transporter
HBM78_00060	COG0596	Alpha beta hydrolase
HBM78_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HBM78_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HBM78_00115	COG0733	neurotransmitter:sodium symporter activity
HBM78_00155	COG2233	PERMEase
HBM78_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_00205	COG2814	Major facilitator Superfamily
HBM78_00210	COG0656	L-ascorbic acid biosynthetic process
HBM78_00215	COG0583	DNA-binding transcription factor activity
HBM78_00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_00235	COG1064	alcohol dehydrogenase
HBM78_00240	COG2818	Glycosylase
HBM78_00255	COG1194	a g-specific adenine glycosylase
HBM78_00275	COG2983	Belongs to the UPF0260 family
HBM78_00280	COG2133	pyrroloquinoline quinone binding
HBM78_00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBM78_00290	COG2116	formate transmembrane transporter activity
HBM78_00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM78_00315	COG1335	isochorismatase
HBM78_00320	COG0385	Bile acid
HBM78_00325	COG0534	Mate efflux family protein
HBM78_00330	COG1683	Conserved Protein
HBM78_00350	COG0625	glutathione transferase activity
HBM78_00360	COG1113	amino acid transport
HBM78_00370	COG0523	cobalamin synthesis protein
HBM78_00380	COG2188	Transcriptional regulator
HBM78_00410	COG0010	Belongs to the arginase family
HBM78_00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBM78_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HBM78_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBM78_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HBM78_00545	COG0534	Mate efflux family protein
HBM78_00550	COG0436	Aminotransferase
HBM78_00555	COG2733	membrane
HBM78_00570	COG2918	glutathione biosynthetic process
HBM78_00580	COG3501	Rhs element vgr protein
HBM78_00585	COG1388	LysM domain
HBM78_00585	COG0791	NLP P60 protein
HBM78_00600	COG3150	esterase
HBM78_00610	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HBM78_00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_00635	COG2233	PERMEase
HBM78_00640	COG2351	hydroxyisourate hydrolase activity
HBM78_00675	COG3706	GGDEF domain
HBM78_00690	COG1393	Belongs to the ArsC family
HBM78_00695	COG0708	Exodeoxyribonuclease III
HBM78_00715	COG0189	ligase activity
HBM78_00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HBM78_00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBM78_00760	COG4942	peptidase
HBM78_00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBM78_00780	COG2119	membrane
HBM78_00785	COG4774	siderophore transport
HBM78_00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_00790	COG0426	domain, Protein
HBM78_00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HBM78_00835	COG1902	pentaerythritol trinitrate reductase activity
HBM78_00840	COG1519	Transferase
HBM78_00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBM78_00850	COG0668	transmembrane transport
HBM78_00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM78_00865	COG1335	isochorismatase
HBM78_00870	COG1522	sequence-specific DNA binding
HBM78_00875	COG3328	transposase activity
HBM78_00900	COG2198	Histidine kinase
HBM78_00900	COG0784	Response regulator, receiver
HBM78_00900	COG2205	protein histidine kinase activity
HBM78_00905	COG3162	membrane
HBM78_00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBM78_00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_00930	COG3706	GGDEF domain
HBM78_00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HBM78_00945	COG1309	transcriptional regulator
HBM78_00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBM78_00965	COG0352	thiamine-phosphate diphosphorylase activity
HBM78_00965	COG0351	phosphomethylpyrimidine kinase
HBM78_00975	COG2814	Major facilitator Superfamily
HBM78_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBM78_01000	COG1113	amino acid transport
HBM78_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBM78_01015	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_01025	COG1335	isochorismatase
HBM78_01055	COG2814	Major facilitator Superfamily
HBM78_01060	COG0583	DNA-binding transcription factor activity
HBM78_01080	COG0667	Aldo Keto reductase
HBM78_01110	COG1733	regulation of RNA biosynthetic process
HBM78_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HBM78_01195	COG2329	Antibiotic biosynthesis monooxygenase
HBM78_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HBM78_01255	COG0427	acetyl-CoA hydrolase
HBM78_01270	COG0745	RESPONSE REGULATOR receiver
HBM78_01280	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_01285	COG4221	oxidoreductase activity
HBM78_01290	COG2873	o-acetylhomoserine
HBM78_01295	COG0488	(ABC) transporter
HBM78_01380	COG0833	amino acid
HBM78_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBM78_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBM78_01445	COG2226	methyltransferase
HBM78_01495	COG0070	glutamate synthase
HBM78_01495	COG0069	glutamate synthase activity
HBM78_01495	COG0067	glutamate synthase
HBM78_01500	COG0493	'glutamate synthase
HBM78_01510	COG1704	LemA family
HBM78_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HBM78_01535	COG3307	-O-antigen
HBM78_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBM78_01570	COG0194	GDP metabolic process
HBM78_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HBM78_01640	COG5380	lipid catabolic process
HBM78_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HBM78_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBM78_01675	COG0277	FAD linked oxidase domain protein
HBM78_01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HBM78_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_01705	COG1289	transmembrane transporter activity
HBM78_01715	COG0628	permease
HBM78_01720	COG1192	Involved in chromosome partitioning
HBM78_01750	COG0833	amino acid
HBM78_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBM78_01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBM78_01770	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_01810	COG0583	DNA-binding transcription factor activity
HBM78_01855	COG0517	IMP dehydrogenase activity
HBM78_01860	COG1983	PspC domain protein
HBM78_01870	COG1960	acyl-CoA dehydrogenase activity
HBM78_01885	COG0408	coproporphyrinogen oxidase activity
HBM78_01905	COG0513	Belongs to the DEAD box helicase family
HBM78_01915	COG1127	ABC transporter
HBM78_01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBM78_01930	COG2854	intermembrane phospholipid transfer
HBM78_01940	COG0598	Magnesium transport protein CorA
HBM78_01950	COG0494	nUDIX hydrolase
HBM78_01955	COG1040	competence protein
HBM78_01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HBM78_01980	COG1946	Acyl-CoA thioesterase
HBM78_01985	COG1301	dicarboxylic acid transport
HBM78_02000	COG1959	2 iron, 2 sulfur cluster binding
HBM78_02005	COG1017	nitric oxide dioxygenase activity
HBM78_02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM78_02010	COG0433	COG0433 Predicted ATPase
HBM78_02015	COG0626	cystathionine gamma-synthase activity
HBM78_02170	COG1960	acyl-CoA dehydrogenase activity
HBM78_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HBM78_02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HBM78_02210	COG0339	signal peptide processing
HBM78_02215	COG0557	exoribonuclease II activity
HBM78_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
HBM78_02265	COG2169	Transcriptional regulator
HBM78_02270	COG0697	spore germination
HBM78_02275	COG1295	ribonuclease BN
HBM78_02310	COG1702	phosphate starvation-inducible protein PhoH
HBM78_02320	COG1196	nuclear chromosome segregation
HBM78_02320	COG0741	lytic transglycosylase activity
HBM78_02320	COG0739	heme binding
HBM78_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBM78_02355	COG1183	phosphatidylcholine synthase activity
HBM78_02400	COG1960	acyl-CoA dehydrogenase activity
HBM78_02405	COG1309	transcriptional regulator
HBM78_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBM78_02425	COG1960	acyl-CoA dehydrogenase activity
HBM78_02445	COG2969	positive regulation of protein catabolic process
HBM78_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HBM78_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HBM78_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HBM78_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBM78_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBM78_02510	COG1408	metallophosphoesterase
HBM78_02520	COG2199	diguanylate cyclase activity
HBM78_02580	COG1607	acyl-coa hydrolase
HBM78_02610	COG2350	Protein conserved in bacteria
HBM78_02620	COG0613	PHP domain protein
HBM78_02625	COG3781	membrane
HBM78_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBM78_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBM78_02650	COG1862	Preprotein translocase
HBM78_02680	COG2205	protein histidine kinase activity
HBM78_02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HBM78_02705	COG0726	polysaccharide deacetylase
HBM78_02710	COG0463	Glycosyl transferase, family 2
HBM78_02715	COG0438	transferase activity, transferring glycosyl groups
HBM78_02780	COG0625	glutathione transferase activity
HBM78_02785	COG0583	DNA-binding transcription factor activity
HBM78_02790	COG1960	acyl-CoA dehydrogenase activity
HBM78_02795	COG1960	acyl-CoA dehydrogenase activity
HBM78_02805	COG2205	protein histidine kinase activity
HBM78_02810	COG0745	RESPONSE REGULATOR receiver
HBM78_02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HBM78_02835	COG2096	Adenosyltransferase
HBM78_02885	COG0285	dihydrofolate synthase activity
HBM78_02905	COG0450	alkyl hydroperoxide reductase
HBM78_02920	COG0477	Major facilitator Superfamily
HBM78_02925	COG1272	protein, Hemolysin III
HBM78_02960	COG0183	Belongs to the thiolase family
HBM78_02965	COG2207	Transcriptional regulator
HBM78_02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_03005	COG0183	Belongs to the thiolase family
HBM78_03015	COG2885	chlorophyll binding
HBM78_03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBM78_03025	COG1690	Belongs to the RtcB family
HBM78_03030	COG0833	amino acid
HBM78_03040	COG2233	PERMEase
HBM78_03070	COG2094	Belongs to the DNA glycosylase MPG family
HBM78_03075	COG4772	TonB-dependent receptor
HBM78_03090	COG1902	pentaerythritol trinitrate reductase activity
HBM78_03095	COG0679	Auxin Efflux Carrier
HBM78_03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM78_03110	COG0354	folic acid binding
HBM78_03120	COG3189	MarR family transcriptional regulator
HBM78_03125	COG2824	Alkylphosphonate utilization operon protein PhnA
HBM78_03130	COG3422	double-strand break repair
HBM78_03170	COG0840	transmembrane signaling receptor activity
HBM78_03190	COG5510	response to toxic substance
HBM78_03200	COG2832	Protein of unknown function (DUF454)
HBM78_03205	COG1376	ErfK ybiS ycfS ynhG family protein
HBM78_03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HBM78_03255	COG1289	transmembrane transporter activity
HBM78_03260	COG2814	Major facilitator Superfamily
HBM78_03280	COG1115	amino acid carrier protein
HBM78_03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBM78_03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBM78_03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HBM78_03335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBM78_03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBM78_03350	COG1077	Cell shape determining protein MreB Mrl
HBM78_03355	COG1792	Involved in formation and maintenance of cell shape
HBM78_03360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HBM78_03365	COG0424	maF-like protein
HBM78_03370	COG1530	ribonuclease E activity
HBM78_03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_03390	COG0560	Phosphoserine phosphatase
HBM78_03400	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_03425	COG2207	Transcriptional regulator
HBM78_03445	COG1113	amino acid transport
HBM78_03450	COG2828	Protein conserved in bacteria
HBM78_03455	COG0142	geranyltranstransferase activity
HBM78_03460	COG2315	Protein conserved in bacteria
HBM78_03475	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBM78_03495	COG2194	sulfuric ester hydrolase activity
HBM78_03500	COG0745	RESPONSE REGULATOR receiver
HBM78_03505	COG0642	Histidine kinase
HBM78_03515	COG0004	ammonium transporteR
HBM78_03520	COG0583	DNA-binding transcription factor activity
HBM78_03540	COG0525	valine-tRNA ligase activity
HBM78_03550	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_03560	COG0393	Putative heavy-metal-binding
HBM78_03565	COG0393	Putative heavy-metal-binding
HBM78_03570	COG1538	Outer membrane efflux protein
HBM78_03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_03585	COG0671	phosphoesterase, PA-phosphatase related
HBM78_03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HBM78_03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBM78_03630	COG1648	precorrin-2 dehydrogenase activity
HBM78_03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBM78_03640	COG1733	regulation of RNA biosynthetic process
HBM78_03650	COG0531	amino acid
HBM78_03665	COG0321	lipoyl(octanoyl) transferase activity
HBM78_03670	COG2921	Belongs to the UPF0250 family
HBM78_03710	COG2009	succinate dehydrogenase
HBM78_03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HBM78_03720	COG1053	succinate dehydrogenase
HBM78_03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBM78_03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM78_03770	COG2354	Protein conserved in bacteria
HBM78_03775	COG2321	neutral zinc metallopeptidase
HBM78_03810	COG2843	Capsule synthesis protein
HBM78_03825	COG0589	response to stress
HBM78_03845	COG0505	Belongs to the CarA family
HBM78_03870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBM78_03875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBM78_03925	COG0477	Major facilitator Superfamily
HBM78_03930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBM78_03945	COG1597	lipid kinase activity
HBM78_03950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBM78_03980	COG0584	glycerophosphoryl diester phosphodiesterase
HBM78_04000	COG0741	lytic transglycosylase activity
HBM78_04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HBM78_04035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_04060	COG0778	Nitroreductase
HBM78_04075	COG1929	Belongs to the glycerate kinase type-1 family
HBM78_04080	COG0243	molybdopterin cofactor binding
HBM78_04085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HBM78_04090	COG3339	Conserved Protein
HBM78_04100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HBM78_04115	COG1113	amino acid transport
HBM78_04125	COG0019	diaminopimelate decarboxylase activity
HBM78_04135	COG1280	lysine exporter protein (LysE YggA)
HBM78_04140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBM78_04170	COG0463	Glycosyl transferase, family 2
HBM78_04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBM78_04230	COG1136	(ABC) transporter
HBM78_04235	COG0658	competence protein
HBM78_04235	COG2333	competence protein COMEC
HBM78_04245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBM78_04245	COG0616	signal peptide processing
HBM78_04250	COG0596	Alpha beta hydrolase
HBM78_04255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBM78_04265	COG0628	permease
HBM78_04300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBM78_04320	COG0823	Involved in the tonB-independent uptake of proteins
HBM78_04340	COG0824	Thioesterase
HBM78_04345	COG1473	amidohydrolase
HBM78_04365	COG0047	phosphoribosylformylglycinamidine synthase activity
HBM78_04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HBM78_04370	COG2814	Major facilitator Superfamily
HBM78_04380	COG1024	Enoyl-CoA hydratase
HBM78_04385	COG1056	cytidyltransferase-related domain
HBM78_04385	COG1051	belongs to the nudix hydrolase family
HBM78_04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBM78_04410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HBM78_04425	COG4625	pathogenesis
HBM78_04430	COG0583	DNA-binding transcription factor activity
HBM78_04435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HBM78_04440	COG4208	sulfate ABC transporter
HBM78_04445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HBM78_04455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HBM78_04460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBM78_04465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBM78_04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBM78_04500	COG0681	Belongs to the peptidase S26 family
HBM78_04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HBM78_04525	COG1381	Involved in DNA repair and RecF pathway recombination
HBM78_04530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HBM78_04540	COG4221	oxidoreductase activity
HBM78_04570	COG0436	Aminotransferase
HBM78_04590	COG0556	nucleotide-excision repair
HBM78_04645	COG2070	2-Nitropropane dioxygenase
HBM78_04675	COG1215	transferase activity, transferring glycosyl groups
HBM78_04690	COG0415	Belongs to the DNA photolyase family
HBM78_04700	COG1252	NADH dehydrogenase
HBM78_04705	COG1686	Belongs to the peptidase S11 family
HBM78_04720	COG1187	pseudouridine synthase activity
HBM78_04745	COG0477	Major facilitator Superfamily
HBM78_04750	COG0583	DNA-binding transcription factor activity
HBM78_04765	COG0612	Peptidase, M16
HBM78_04790	COG0352	thiamine-phosphate diphosphorylase activity
HBM78_04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM78_04840	COG1309	transcriptional regulator
HBM78_04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBM78_04855	COG0076	glutamate decarboxylase activity
HBM78_04865	COG1522	sequence-specific DNA binding
HBM78_04870	COG3961	Belongs to the TPP enzyme family
HBM78_04875	COG1113	amino acid transport
HBM78_04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HBM78_04885	COG0573	inorganic phosphate transmembrane transporter activity
HBM78_04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HBM78_04900	COG0616	signal peptide processing
HBM78_04910	COG3328	transposase activity
HBM78_04940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HBM78_04945	COG1686	Belongs to the peptidase S11 family
HBM78_04970	COG0583	DNA-binding transcription factor activity
HBM78_04975	COG1067	ATP-dependent peptidase activity
HBM78_05020	COG1966	Carbon starvation protein
HBM78_05025	COG2879	small protein
HBM78_05060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HBM78_05060	COG2508	Transcriptional regulator
HBM78_05080	COG1113	amino acid transport
HBM78_05085	COG0583	DNA-binding transcription factor activity
HBM78_05090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_05095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_05105	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_05110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM78_05115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HBM78_05150	COG2814	Major facilitator Superfamily
HBM78_05155	COG4948	Mandelate Racemase Muconate Lactonizing
HBM78_05165	COG1309	transcriptional regulator
HBM78_05185	COG1741	Belongs to the pirin family
HBM78_05195	COG2964	Protein conserved in bacteria
HBM78_05210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_05215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBM78_05220	COG4605	iron ion homeostasis
HBM78_05225	COG4604	ABC transporter, ATP-binding protein
HBM78_05230	COG4607	ABC-type enterochelin transport system periplasmic component
HBM78_05235	COG4774	siderophore transport
HBM78_05245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_05250	COG1021	2,3-dihydroxybenzoate-AMP ligase
HBM78_05255	COG1535	isochorismatase
HBM78_05255	COG3433	isochorismatase activity
HBM78_05270	COG1132	(ABC) transporter
HBM78_05280	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HBM78_05290	COG1169	isochorismate synthase
HBM78_05305	COG3739	integral membrane protein
HBM78_05340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HBM78_05370	COG0308	aminopeptidase N
HBM78_05375	COG0512	Glutamine amidotransferase of anthranilate synthase
HBM78_05545	COG5410	chromosome segregation
HBM78_05745	COG0582	viral genome integration into host DNA
HBM78_05755	COG3104	oligopeptide transport
HBM78_05760	COG0174	glutamine synthetase
HBM78_05770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBM78_05805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HBM78_05810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HBM78_05815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBM78_05835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBM78_05840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HBM78_05845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBM78_05860	COG1960	acyl-CoA dehydrogenase activity
HBM78_05865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBM78_05870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM78_05880	COG2223	nitrite transmembrane transporter activity
HBM78_05890	COG0024	Methionine aminopeptidase
HBM78_05895	COG0052	Belongs to the universal ribosomal protein uS2 family
HBM78_05910	COG2207	Transcriptional regulator
HBM78_05935	COG2951	lytic endotransglycosylase activity
HBM78_05940	COG0772	Belongs to the SEDS family
HBM78_05955	COG0842	Transport permease protein
HBM78_05960	COG1131	(ABC) transporter
HBM78_06005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_06020	COG4215	(ABC) transporter
HBM78_06025	COG4160	amino acid transport
HBM78_06030	COG4598	ABC transporter
HBM78_06040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBM78_06050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_06065	COG1720	tRNA m6t6A37 methyltransferase activity
HBM78_06085	COG0745	RESPONSE REGULATOR receiver
HBM78_06090	COG0642	Histidine kinase
HBM78_06100	COG0494	nUDIX hydrolase
HBM78_06110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HBM78_06115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HBM78_06120	COG3139	Protein of unknown function (DUF1315)
HBM78_06125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBM78_06130	COG1301	dicarboxylic acid transport
HBM78_06135	COG1960	acyl-CoA dehydrogenase activity
HBM78_06140	COG2819	hydrolase of the alpha beta superfamily
HBM78_06150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HBM78_06160	COG2195	Cleaves the N-terminal amino acid of tripeptides
HBM78_06165	COG1234	tRNA 3'-trailer cleavage
HBM78_06195	COG2363	Small membrane protein
HBM78_06215	COG0513	Belongs to the DEAD box helicase family
HBM78_06225	COG0778	Nitroreductase
HBM78_06255	COG1286	toxin biosynthetic process
HBM78_06280	COG4783	chaperone-mediated protein folding
HBM78_06285	COG1610	YqeY-like protein
HBM78_06385	COG3111	PFAM Bacterial OB fold (BOF) protein
HBM78_06410	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBM78_06415	COG0786	glutamate:sodium symporter activity
HBM78_06425	COG2186	Transcriptional regulator
HBM78_06475	COG0477	Major facilitator Superfamily
HBM78_06500	COG2985	domain, Protein
HBM78_06510	COG2995	paraquat-inducible protein a
HBM78_06515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBM78_06515	COG3008	intermembrane lipid transfer
HBM78_06535	COG0482	sulfurtransferase activity
HBM78_06555	COG3173	Aminoglycoside phosphotransferase
HBM78_06565	COG2433	Pfam Transposase IS66
HBM78_06605	COG1301	dicarboxylic acid transport
HBM78_06615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM78_06620	COG2011	ABC-type metal ion transport system permease component
HBM78_06625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBM78_06630	COG1464	Belongs to the NlpA lipoprotein family
HBM78_06635	COG0151	Belongs to the GarS family
HBM78_06640	COG0138	bifunctional purine biosynthesis protein purh
HBM78_06645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBM78_06675	COG2308	Evidence 4 Homologs of previously reported genes of
HBM78_06685	COG1305	Transglutaminase-like
HBM78_06695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HBM78_06700	COG0305	Participates in initiation and elongation during chromosome replication
HBM78_06725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HBM78_06735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HBM78_06740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HBM78_06765	COG1649	PFAM Uncharacterised BCR, COG1649
HBM78_06765	COG0726	polysaccharide deacetylase
HBM78_06770	COG1215	transferase activity, transferring glycosyl groups
HBM78_06775	COG3658	cytochrome
HBM78_06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM78_06800	COG0583	DNA-binding transcription factor activity
HBM78_06820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_06825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_06840	COG1960	acyl-CoA dehydrogenase activity
HBM78_06845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM78_06850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_06875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HBM78_06880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HBM78_06890	COG2205	protein histidine kinase activity
HBM78_06895	COG0745	RESPONSE REGULATOR receiver
HBM78_06900	COG0174	glutamine synthetase
HBM78_06920	COG0729	surface antigen
HBM78_06945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBM78_06950	COG2814	Major facilitator Superfamily
HBM78_06965	COG0583	DNA-binding transcription factor activity
HBM78_06980	COG1187	pseudouridine synthase activity
HBM78_07000	COG0802	atpase or kinase
HBM78_07005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBM78_07015	COG1923	regulation of RNA biosynthetic process
HBM78_07020	COG0697	spore germination
HBM78_07035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM78_07045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBM78_07050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBM78_07050	COG0519	Catalyzes the synthesis of GMP from XMP
HBM78_07055	COG4302	ethanolamine ammonia-lyase activity
HBM78_07060	COG4303	Ethanolamine ammonia lyase large subunit
HBM78_07065	COG0531	amino acid
HBM78_07085	COG1454	alcohol dehydrogenase
HBM78_07090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBM78_07100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HBM78_07120	COG0308	aminopeptidase N
HBM78_07150	COG1605	Chorismate mutase
HBM78_07165	COG1309	transcriptional regulator
HBM78_07175	COG0668	transmembrane transport
HBM78_07210	COG4773	Receptor
HBM78_07245	COG3135	benzoate transporter
HBM78_07250	COG1522	sequence-specific DNA binding
HBM78_07260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HBM78_07265	COG0583	DNA-binding transcription factor activity
HBM78_07275	COG0183	Belongs to the thiolase family
HBM78_07285	COG2030	dehydratase
HBM78_07305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HBM78_07315	COG0824	Thioesterase
HBM78_07320	COG1454	alcohol dehydrogenase
HBM78_07330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HBM78_07515	COG5410	chromosome segregation
HBM78_07635	COG0739	heme binding
HBM78_07700	COG2814	Major facilitator Superfamily
HBM78_07715	COG0511	ligase activity, forming carbon-carbon bonds
HBM78_07735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_07735	COG1116	anion transmembrane transporter activity
HBM78_07740	COG0745	RESPONSE REGULATOR receiver
HBM78_07750	COG2146	nitrite reductase [NAD(P)H] activity
HBM78_07750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_07755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_07760	COG0243	molybdopterin cofactor binding
HBM78_07770	COG0243	molybdopterin cofactor binding
HBM78_07775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HBM78_07790	COG0315	cyclic pyranopterin monophosphate synthase activity
HBM78_07790	COG0521	Mo-molybdopterin cofactor biosynthetic process
HBM78_07795	COG0303	'Molybdopterin
HBM78_07805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_07810	COG0697	spore germination
HBM78_07830	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HBM78_07835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBM78_07890	COG2204	response regulator
HBM78_07895	COG3852	Histidine kinase
HBM78_07915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HBM78_07920	COG0575	Belongs to the CDS family
HBM78_07955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM78_07970	COG2137	regulation of response to DNA damage stimulus
HBM78_07980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HBM78_07985	COG1011	Hydrolase
HBM78_08010	COG1522	sequence-specific DNA binding
HBM78_08020	COG1113	amino acid transport
HBM78_08035	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_08040	COG2135	peptidase activity
HBM78_08055	COG3300	MHYT domain
HBM78_08055	COG5001	Diguanylate cyclase
HBM78_08075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBM78_08075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBM78_08075	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HBM78_08080	COG1105	Belongs to the carbohydrate kinase PfkB family
HBM78_08085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBM78_08085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBM78_08115	COG0024	Methionine aminopeptidase
HBM78_08120	COG0583	DNA-binding transcription factor activity
HBM78_08130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBM78_08135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBM78_08140	COG0517	IMP dehydrogenase activity
HBM78_08140	COG0516	GMP reductase activity
HBM78_08165	COG0552	protein localization to endoplasmic reticulum
HBM78_08175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HBM78_08190	COG4890	Cyd operon protein YbgT
HBM78_08195	COG1294	oxidase, subunit
HBM78_08210	COG1585	Membrane protein implicated in regulation of membrane protease activity
HBM78_08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBM78_08225	COG4774	siderophore transport
HBM78_08240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBM78_08245	COG0569	domain protein
HBM78_08250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBM78_08280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HBM78_08285	COG0542	response to heat
HBM78_08310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_08310	COG1902	pentaerythritol trinitrate reductase activity
HBM78_08355	COG2323	membrane
HBM78_08360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HBM78_08370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM78_08375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_08380	COG0183	Belongs to the thiolase family
HBM78_08385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HBM78_08390	COG0596	Alpha beta hydrolase
HBM78_08395	COG2271	Major facilitator Superfamily
HBM78_08400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBM78_08405	COG3485	protocatechuate 3,4-dioxygenase
HBM78_08410	COG3485	protocatechuate 3,4-dioxygenase
HBM78_08415	COG0710	3-dehydroquinate dehydratase activity
HBM78_08420	COG3420	alginic acid biosynthetic process
HBM78_08425	COG3659	wide pore channel activity
HBM78_08430	COG4993	Dehydrogenase
HBM78_08440	COG2391	methyltransferase activity
HBM78_08455	COG1414	Transcriptional regulator
HBM78_08460	COG0583	DNA-binding transcription factor activity
HBM78_08465	COG1960	acyl-CoA dehydrogenase activity
HBM78_08490	COG2814	Major facilitator Superfamily
HBM78_08500	COG0154	amidase activity
HBM78_08520	COG4638	Rieske (2fe-2S)
HBM78_08530	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_08540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_08550	COG3733	amine oxidase
HBM78_08560	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_08570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM78_08575	COG0183	Belongs to the thiolase family
HBM78_08580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_08585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM78_08595	COG4829	muconolactone delta-isomerase
HBM78_08600	COG4948	Mandelate Racemase Muconate Lactonizing
HBM78_08605	COG0583	DNA-binding transcription factor activity
HBM78_08615	COG2186	Transcriptional regulator
HBM78_08635	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_08655	COG1960	acyl-CoA dehydrogenase activity
HBM78_08660	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_08665	COG3829	transcription factor binding
HBM78_08675	COG3162	membrane
HBM78_08690	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_08705	COG0753	catalase activity
HBM78_08725	COG1846	Transcriptional regulator
HBM78_08730	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_08730	COG1902	pentaerythritol trinitrate reductase activity
HBM78_08740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBM78_08770	COG1309	transcriptional regulator
HBM78_08780	COG1335	isochorismatase
HBM78_08785	COG0583	DNA-binding transcription factor activity
HBM78_08795	COG0475	glutathione-regulated potassium exporter activity
HBM78_08795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM78_08805	COG1473	amidohydrolase
HBM78_08815	COG2831	hemolysin activation secretion protein
HBM78_08860	COG2188	Transcriptional regulator
HBM78_08875	COG0583	DNA-binding transcription factor activity
HBM78_08905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBM78_08925	COG1566	PFAM secretion protein HlyD family protein
HBM78_08940	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_08945	COG0129	dihydroxy-acid dehydratase activity
HBM78_08955	COG0583	DNA-binding transcription factor activity
HBM78_08960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBM78_08970	COG2084	Dehydrogenase
HBM78_08975	COG2207	Transcriptional regulator
HBM78_08990	COG1064	alcohol dehydrogenase
HBM78_09005	COG1120	ATPase activity
HBM78_09025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBM78_09140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HBM78_09190	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_09205	COG2207	Transcriptional regulator
HBM78_09215	COG2205	protein histidine kinase activity
HBM78_09220	COG0745	RESPONSE REGULATOR receiver
HBM78_09225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_09230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBM78_09235	COG1538	Outer membrane efflux protein
HBM78_09245	COG2072	flavoprotein involved in K transport
HBM78_09265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM78_09285	COG3539	Fimbrial protein
HBM78_09315	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HBM78_09325	COG0753	catalase activity
HBM78_09340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBM78_09405	COG1535	isochorismatase
HBM78_09405	COG3433	isochorismatase activity
HBM78_09410	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_09415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HBM78_09420	COG4149	molybdate abc transporter
HBM78_09425	COG0725	ABC transporter, periplasmic molybdate-binding protein
HBM78_09435	COG4638	Rieske (2fe-2S)
HBM78_09440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBM78_09445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM78_09445	COG0543	2 iron, 2 sulfur cluster binding
HBM78_09470	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_09485	COG2207	Transcriptional regulator
HBM78_09495	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_09500	COG2610	gluconate transmembrane transporter activity
HBM78_09510	COG0583	DNA-binding transcription factor activity
HBM78_09520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_09525	COG2031	fatty acid transporter
HBM78_09530	COG0183	Belongs to the thiolase family
HBM78_09535	COG0583	DNA-binding transcription factor activity
HBM78_09540	COG0583	DNA-binding transcription factor activity
HBM78_09555	COG1027	Aspartate ammonia-lyase
HBM78_09565	COG0477	Major facilitator Superfamily
HBM78_09585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_09590	COG4521	taurine ABC transporter
HBM78_09605	COG2188	Transcriptional regulator
HBM78_09615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HBM78_09620	COG1733	regulation of RNA biosynthetic process
HBM78_09625	COG2207	Transcriptional regulator
HBM78_09625	COG3708	Transcriptional regulator
HBM78_09640	COG0730	response to heat
HBM78_09650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM78_09650	COG3453	Protein conserved in bacteria
HBM78_09660	COG3781	membrane
HBM78_09665	COG1063	alcohol dehydrogenase
HBM78_09675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM78_09680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBM78_09685	COG0022	dehydrogenase e1 component
HBM78_09690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HBM78_09695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBM78_09710	COG3706	GGDEF domain
HBM78_09725	COG0133	tryptophan synthase activity
HBM78_09735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBM78_09770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HBM78_09795	COG2226	methyltransferase
HBM78_09850	COG0842	Transport permease protein
HBM78_09855	COG0842	Transport permease protein
HBM78_09860	COG1131	(ABC) transporter
HBM78_09875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM78_09880	COG4773	Receptor
HBM78_09900	COG0730	response to heat
HBM78_09905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBM78_09925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HBM78_09980	COG4264	IucA IucC family
HBM78_09985	COG4264	IucA IucC family
HBM78_10005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HBM78_10020	COG1960	acyl-CoA dehydrogenase activity
HBM78_10025	COG1960	acyl-CoA dehydrogenase activity
HBM78_10030	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBM78_10035	COG2207	Transcriptional regulator
HBM78_10040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBM78_10045	COG0776	regulation of translation
HBM78_10070	COG0822	iron-sulfur transferase activity
HBM78_10075	COG0316	Belongs to the HesB IscA family
HBM78_10105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBM78_10125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBM78_10130	COG0702	epimerase
HBM78_10165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBM78_10175	COG0339	signal peptide processing
HBM78_10225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HBM78_10230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HBM78_10260	COG0776	regulation of translation
HBM78_10325	COG0084	hydrolase, TatD family'
HBM78_10345	COG1663	tetraacyldisaccharide 4'-kinase activity
HBM78_10350	COG1132	(ABC) transporter
HBM78_10360	COG0811	peptide transport
HBM78_10365	COG1475	DNA binding
HBM78_10370	COG1192	Involved in chromosome partitioning
HBM78_10380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBM78_10395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBM78_10400	COG0191	fructose-bisphosphate aldolase activity
HBM78_10420	COG0424	maF-like protein
HBM78_10425	COG2850	peptidyl-arginine hydroxylation
HBM78_10435	COG0640	Transcriptional regulator
HBM78_10445	COG3619	membrane
HBM78_10450	COG3122	Protein conserved in bacteria
HBM78_10455	COG1132	(ABC) transporter
HBM78_10475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HBM78_10480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBM78_10490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBM78_10490	COG0506	proline dehydrogenase activity
HBM78_10490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBM78_10495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBM78_10510	COG3698	Phosphodiester glycosidase
HBM78_10520	COG2353	YceI-like domain
HBM78_10530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HBM78_10575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HBM78_10575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HBM78_10600	COG3539	Fimbrial protein
HBM78_10605	COG3121	Chaperone
HBM78_10635	COG0697	spore germination
HBM78_10645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBM78_10655	COG0583	DNA-binding transcription factor activity
HBM78_10675	COG1309	transcriptional regulator
HBM78_10690	COG1522	sequence-specific DNA binding
HBM78_10700	COG1126	abc transporter atp-binding protein
HBM78_10705	COG0765	amino acid transport
HBM78_10710	COG0765	amino acid transport
HBM78_10740	COG1464	Belongs to the NlpA lipoprotein family
HBM78_10750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBM78_10755	COG2011	ABC-type metal ion transport system permease component
HBM78_10760	COG0012	GTP binding
HBM78_10785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBM78_10825	COG0386	Belongs to the glutathione peroxidase family
HBM78_10835	COG0436	Aminotransferase
HBM78_10875	COG3634	alkyl hydroperoxide reductase activity
HBM78_10890	COG0583	DNA-binding transcription factor activity
HBM78_10895	COG0798	PFAM Bile acid sodium symporter
HBM78_10900	COG0640	Transcriptional regulator
HBM78_10915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HBM78_10925	COG0583	DNA-binding transcription factor activity
HBM78_10935	COG1953	Uracil, thiamine, allantoin
HBM78_10945	COG2175	clavaminate synthase activity
HBM78_10950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_10955	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HBM78_10960	COG4521	taurine ABC transporter
HBM78_10970	COG0477	Major facilitator Superfamily
HBM78_10990	COG1271	oxidase subunit
HBM78_10995	COG1294	oxidase, subunit
HBM78_11005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_11025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBM78_11045	COG3052	prosthetic group binding
HBM78_11050	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HBM78_11060	COG2814	Major facilitator Superfamily
HBM78_11080	COG1346	cytolysis
HBM78_11090	COG0583	DNA-binding transcription factor activity
HBM78_11095	COG0625	glutathione transferase activity
HBM78_11100	COG0625	glutathione transferase activity
HBM78_11105	COG0583	DNA-binding transcription factor activity
HBM78_11120	COG1045	serine acetyltransferase
HBM78_11125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBM78_11130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBM78_11140	COG1280	lysine exporter protein (LysE YggA)
HBM78_11160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM78_11165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM78_11170	COG1126	abc transporter atp-binding protein
HBM78_11175	COG0765	amino acid transport
HBM78_11180	COG0765	amino acid transport
HBM78_11200	COG0784	Response regulator, receiver
HBM78_11200	COG2205	protein histidine kinase activity
HBM78_11220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBM78_11240	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_11290	COG0583	DNA-binding transcription factor activity
HBM78_11310	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_11315	COG1309	transcriptional regulator
HBM78_11320	COG1960	acyl-CoA dehydrogenase activity
HBM78_11325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBM78_11330	COG1024	Enoyl-CoA hydratase
HBM78_11335	COG4770	biotin carboxylase activity
HBM78_11345	COG0583	DNA-binding transcription factor activity
HBM78_11360	COG1960	acyl-CoA dehydrogenase activity
HBM78_11370	COG2814	Major facilitator Superfamily
HBM78_11380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_11385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM78_11390	COG2814	Major facilitator Superfamily
HBM78_11395	COG1960	acyl-CoA dehydrogenase activity
HBM78_11400	COG1024	Enoyl-CoA hydratase
HBM78_11405	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM78_11415	COG0183	Belongs to the thiolase family
HBM78_11425	COG2814	Major facilitator Superfamily
HBM78_11435	COG1024	Enoyl-CoA hydratase
HBM78_11450	COG1960	acyl-CoA dehydrogenase activity
HBM78_11455	COG2814	Major facilitator Superfamily
HBM78_11460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBM78_11465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HBM78_11480	COG3842	ATPase activity
HBM78_11485	COG1840	ABC-type Fe3 transport system, periplasmic component
HBM78_11495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_11500	COG1414	Transcriptional regulator
HBM78_11510	COG0583	DNA-binding transcription factor activity
HBM78_11515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBM78_11520	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_11530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBM78_11540	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_11545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM78_11550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_11555	COG2267	carboxylic ester hydrolase activity
HBM78_11575	COG3038	cytochrome b561
HBM78_11580	COG0753	catalase activity
HBM78_11615	COG2050	protein possibly involved in aromatic compounds catabolism
HBM78_11640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBM78_11655	COG2807	transmembrane transport
HBM78_11660	COG0590	tRNA wobble adenosine to inosine editing
HBM78_11775	COG1116	anion transmembrane transporter activity
HBM78_11780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM78_11790	COG0864	Transcriptional regulator
HBM78_11810	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_11815	COG0439	Biotin carboxylase
HBM78_11830	COG1063	alcohol dehydrogenase
HBM78_11840	COG1309	transcriptional regulator
HBM78_11860	COG0038	chloride channel
HBM78_11865	COG4770	biotin carboxylase activity
HBM78_11885	COG1914	H( )-stimulated, divalent metal cation uptake system
HBM78_11890	COG0583	DNA-binding transcription factor activity
HBM78_11905	COG3209	COG3209 Rhs family protein
HBM78_11910	COG3501	Rhs element vgr protein
HBM78_11940	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM78_11960	COG2814	Major facilitator Superfamily
HBM78_11970	COG1560	Kdo2-lipid A biosynthetic process
HBM78_11980	COG5006	permease, DMT superfamily
HBM78_11985	COG1522	sequence-specific DNA binding
HBM78_12000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HBM78_12010	COG4122	O-methyltransferase activity
HBM78_12040	COG1538	Outer membrane efflux protein
HBM78_12050	COG1137	ATPase activity
HBM78_12055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HBM78_12065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBM78_12070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HBM78_12070	COG0517	IMP dehydrogenase activity
HBM78_12110	COG2814	Major facilitator Superfamily
HBM78_12145	COG1278	Cold shock
HBM78_12150	COG1280	lysine exporter protein (LysE YggA)
HBM78_12185	COG1570	exodeoxyribonuclease VII activity
HBM78_12235	COG0583	DNA-binding transcription factor activity
HBM78_12240	COG4638	Rieske (2fe-2S)
HBM78_12245	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBM78_12250	COG0633	Ferredoxin
HBM78_12250	COG0543	2 iron, 2 sulfur cluster binding
HBM78_12255	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_12260	COG3135	benzoate transporter
HBM78_12265	COG2814	Major facilitator Superfamily
HBM78_12280	COG1643	Atp-dependent helicase
HBM78_12285	COG0450	alkyl hydroperoxide reductase
HBM78_12295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBM78_12305	COG3634	alkyl hydroperoxide reductase activity
HBM78_12325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HBM78_12330	COG0625	glutathione transferase activity
HBM78_12340	COG2885	chlorophyll binding
HBM78_12375	COG0542	response to heat
HBM78_12390	COG1765	OsmC-like protein
HBM78_12405	COG0667	Aldo Keto reductase
HBM78_12420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HBM78_12430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HBM78_12440	COG0527	aspartate kinase activity
HBM78_12450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HBM78_12460	COG3038	cytochrome b561
HBM78_12465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HBM78_12470	COG2252	PERMEase
HBM78_12480	COG2072	flavoprotein involved in K transport
HBM78_12495	COG1741	Belongs to the pirin family
HBM78_12500	COG1309	transcriptional regulator
HBM78_12525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HBM78_12565	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_12565	COG1902	pentaerythritol trinitrate reductase activity
HBM78_12575	COG2203	Gaf domain
HBM78_12575	COG3706	GGDEF domain
HBM78_12575	COG4251	negative regulation of phosphorylation
HBM78_12575	COG5001	Diguanylate cyclase
HBM78_12585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM78_12605	COG4172	Belongs to the ABC transporter superfamily
HBM78_12610	COG4239	(ABC) transporter, permease
HBM78_12615	COG4174	ABC transporter (Permease)
HBM78_12625	COG0741	lytic transglycosylase activity
HBM78_12625	COG1388	LysM domain
HBM78_12625	COG0741	lytic transglycosylase activity
HBM78_12625	COG1388	LysM domain
HBM78_12630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM78_12670	COG0583	DNA-binding transcription factor activity
HBM78_12675	COG1279	arginine transmembrane transporter activity
HBM78_12695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_12700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_12705	COG0006	proline dipeptidase activity
HBM78_12740	COG2194	sulfuric ester hydrolase activity
HBM78_12785	COG0739	heme binding
HBM78_13215	COG4695	Portal protein
HBM78_13310	COG0305	Participates in initiation and elongation during chromosome replication
HBM78_13325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBM78_13380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HBM78_13405	COG3384	dioxygenase
HBM78_13415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBM78_13420	COG2878	Part of a membrane complex involved in electron transport
HBM78_13425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBM78_13450	COG0768	penicillin binding
HBM78_13455	COG0742	ribosomal rna small subunit methyltransferase
HBM78_13470	COG0830	nickel cation binding
HBM78_13480	COG0804	urea catabolic process
HBM78_13520	COG1253	flavin adenine dinucleotide binding
HBM78_13525	COG2851	Citrate transporter
HBM78_13580	COG1773	rubredoxin
HBM78_13585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_13595	COG0583	DNA-binding transcription factor activity
HBM78_13620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HBM78_13625	COG4181	ATPase activity
HBM78_13670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HBM78_13690	COG0306	phosphate transporter
HBM78_13700	COG3958	Transketolase
HBM78_13705	COG3959	Transketolase, thiamine diphosphate binding domain
HBM78_13710	COG2271	Major facilitator Superfamily
HBM78_13715	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_13720	COG0583	DNA-binding transcription factor activity
HBM78_13735	COG2223	nitrite transmembrane transporter activity
HBM78_13740	COG2207	Transcriptional regulator
HBM78_13745	COG2066	Belongs to the glutaminase family
HBM78_13750	COG0242	peptide deformylase activity
HBM78_13755	COG0477	Major facilitator Superfamily
HBM78_13765	COG0028	Belongs to the TPP enzyme family
HBM78_13780	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_13785	COG2267	carboxylic ester hydrolase activity
HBM78_13795	COG2271	Major facilitator Superfamily
HBM78_13800	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_13810	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_13830	COG1414	Transcriptional regulator
HBM78_13845	COG1024	Enoyl-CoA hydratase
HBM78_13855	COG1215	transferase activity, transferring glycosyl groups
HBM78_13860	COG0726	polysaccharide deacetylase
HBM78_13860	COG1649	PFAM Uncharacterised BCR, COG1649
HBM78_13870	COG4681	YaeQ
HBM78_13880	COG0523	cobalamin synthesis protein
HBM78_13890	COG1607	acyl-coa hydrolase
HBM78_13900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_13905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_13910	COG1309	transcriptional regulator
HBM78_13935	COG2040	homocysteine
HBM78_13940	COG0531	amino acid
HBM78_13995	COG1595	DNA-templated transcription, initiation
HBM78_14005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM78_14010	COG0477	Major facilitator Superfamily
HBM78_14030	COG0084	hydrolase, TatD family'
HBM78_14065	COG0629	single-stranded DNA binding
HBM78_14120	COG0582	viral genome integration into host DNA
HBM78_14130	COG0405	Gamma-glutamyltransferase
HBM78_14135	COG2814	Major facilitator Superfamily
HBM78_14145	COG2050	protein possibly involved in aromatic compounds catabolism
HBM78_14160	COG1090	epimerase
HBM78_14180	COG0420	3'-5' exonuclease activity
HBM78_14205	COG0735	belongs to the Fur family
HBM78_14210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HBM78_14230	COG0121	glutamine amidotransferase
HBM78_14245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM78_14255	COG0210	DNA helicase
HBM78_14260	COG2885	chlorophyll binding
HBM78_14265	COG0204	Acyl-transferase
HBM78_14280	COG2894	cell division
HBM78_14300	COG1280	lysine exporter protein (LysE YggA)
HBM78_14305	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBM78_14305	COG1674	ftsk spoiiie
HBM78_14310	COG0492	ferredoxin-NADP+ reductase activity
HBM78_14315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HBM78_14325	COG0456	acetyltransferase
HBM78_14385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBM78_14385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBM78_14405	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_14425	COG0473	3-isopropylmalate dehydrogenase activity
HBM78_14430	COG0583	DNA-binding transcription factor activity
HBM78_14450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBM78_14475	COG0564	pseudouridine synthase activity
HBM78_14485	COG0358	DNA primase activity
HBM78_14500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HBM78_14530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBM78_14560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBM78_14570	COG0352	thiamine-phosphate diphosphorylase activity
HBM78_14570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBM78_14570	COG0351	phosphomethylpyrimidine kinase
HBM78_14575	COG1652	LysM domain
HBM78_14600	COG1399	metal-binding, possibly nucleic acid-binding protein
HBM78_14605	COG3101	peptidyl-lysine hydroxylation
HBM78_14610	COG0009	L-threonylcarbamoyladenylate synthase
HBM78_14615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HBM78_14620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HBM78_14635	COG4106	trans-aconitate 2-methyltransferase activity
HBM78_14650	COG2226	methyltransferase
HBM78_14650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM78_14650	COG0596	Alpha beta hydrolase
HBM78_14655	COG1877	trehalose-phosphatase activity
HBM78_14660	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HBM78_14665	COG2223	nitrite transmembrane transporter activity
HBM78_14685	COG1196	nuclear chromosome segregation
HBM78_14695	COG0730	response to heat
HBM78_14710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBM78_14720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBM78_14770	COG0489	protein tyrosine kinase activity
HBM78_14780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM78_14780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM78_14810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HBM78_14815	COG2081	HI0933 family
HBM78_14825	COG0668	transmembrane transport
HBM78_14845	COG0583	DNA-binding transcription factor activity
HBM78_14865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBM78_14870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBM78_14900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HBM78_14935	COG2205	protein histidine kinase activity
HBM78_14940	COG0745	RESPONSE REGULATOR receiver
HBM78_14960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBM78_14970	COG2205	protein histidine kinase activity
HBM78_15040	COG4993	Dehydrogenase
HBM78_15060	COG0384	phenazine biosynthesis protein PhzF
HBM78_15080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_15095	COG0583	DNA-binding transcription factor activity
HBM78_15115	COG1473	amidohydrolase
HBM78_15125	COG0583	DNA-binding transcription factor activity
HBM78_15140	COG0583	DNA-binding transcription factor activity
HBM78_15145	COG1053	succinate dehydrogenase
HBM78_15155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HBM78_15160	COG2814	Major facilitator Superfamily
HBM78_15165	COG1960	acyl-CoA dehydrogenase activity
HBM78_15170	COG0583	DNA-binding transcription factor activity
HBM78_15175	COG1063	alcohol dehydrogenase
HBM78_15205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HBM78_15210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HBM78_15215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBM78_15230	COG3667	copper resistance
HBM78_15235	COG2132	Multicopper oxidase
HBM78_15245	COG0561	phosphatase activity
HBM78_15250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBM78_15275	COG1214	PFAM Peptidase M22, glycoprotease
HBM78_15325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBM78_15335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBM78_15340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBM78_15345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HBM78_15405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBM78_15415	COG1846	Transcriptional regulator
HBM78_15420	COG1764	response to oxidative stress
HBM78_15470	COG0037	tRNA processing
HBM78_15480	COG0248	Ppx GppA phosphatase
HBM78_15510	COG0072	phenylalanine-tRNA ligase activity
HBM78_15550	COG1238	metal cluster binding
HBM78_15555	COG0625	glutathione transferase activity
HBM78_15570	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_15575	COG3028	Belongs to the UPF0307 family
HBM78_15580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBM78_15600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBM78_15605	COG0617	tRNA 3'-terminal CCA addition
HBM78_15610	COG1555	photosystem II stabilization
HBM78_15615	COG3956	TIGRFAM MazG family protein
HBM78_15625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBM78_15645	COG0784	Response regulator, receiver
HBM78_15645	COG2205	protein histidine kinase activity
HBM78_15645	COG5002	protein histidine kinase activity
HBM78_15650	COG1024	Enoyl-CoA hydratase
HBM78_15655	COG2084	Dehydrogenase
HBM78_15660	COG3622	Belongs to the hyi family
HBM78_15690	COG0697	spore germination
HBM78_15700	COG2814	Major facilitator Superfamily
HBM78_15705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBM78_15715	COG0583	DNA-binding transcription factor activity
HBM78_15725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HBM78_15740	COG0084	hydrolase, TatD family'
HBM78_15755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HBM78_15785	COG0440	acetolactate synthase activity
HBM78_15790	COG0028	Belongs to the TPP enzyme family
HBM78_15815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_15820	COG0577	efflux transmembrane transporter activity
HBM78_15820	COG1136	(ABC) transporter
HBM78_15825	COG1538	Outer membrane efflux protein
HBM78_15840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HBM78_15845	COG1162	GTPase activity
HBM78_15855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBM78_15875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBM78_15880	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_15920	COG2986	histidine ammonia-lyase
HBM78_15935	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_15945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBM78_15990	COG1426	Protein conserved in bacteria
HBM78_16025	COG0793	Belongs to the peptidase S41A family
HBM78_16040	COG2267	carboxylic ester hydrolase activity
HBM78_16050	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_16055	COG3265	gluconokinase activity
HBM78_16065	COG0800	Aldolase
HBM78_16080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HBM78_16085	COG0857	belongs to the CobB CobQ family
HBM78_16085	COG0280	phosphate acetyltransferase
HBM78_16090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HBM78_16090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HBM78_16110	COG0740	serine-type endopeptidase activity
HBM78_16120	COG4774	siderophore transport
HBM78_16130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HBM78_16140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM78_16140	COG2813	Specifically methylates the guanine in position
HBM78_16240	COG0788	formyltetrahydrofolate deformylase activity
HBM78_16265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM78_16265	COG4651	solute:proton antiporter activity
HBM78_16285	COG0724	RNA recognition motif
HBM78_16290	COG0210	DNA helicase
HBM78_16315	COG1733	regulation of RNA biosynthetic process
HBM78_16325	COG2900	Belongs to the SlyX family
HBM78_16335	COG1280	lysine exporter protein (LysE YggA)
HBM78_16340	COG1560	Kdo2-lipid A biosynthetic process
HBM78_16350	COG1301	dicarboxylic acid transport
HBM78_16405	COG0473	3-isopropylmalate dehydrogenase activity
HBM78_16470	COG0583	DNA-binding transcription factor activity
HBM78_16480	COG0625	glutathione transferase activity
HBM78_16485	COG2378	regulation of single-species biofilm formation
HBM78_16490	COG0546	phosphoglycolate phosphatase activity
HBM78_16505	COG1530	ribonuclease E activity
HBM78_16510	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_16525	COG0583	DNA-binding transcription factor activity
HBM78_16530	COG4221	oxidoreductase activity
HBM78_16535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBM78_16545	COG0534	Mate efflux family protein
HBM78_16560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBM78_16600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HBM78_16605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM78_16620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBM78_16630	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HBM78_16630	COG0644	oxidoreductase
HBM78_16635	COG0425	Belongs to the sulfur carrier protein TusA family
HBM78_16640	COG4535	Mg2 and Co2 transporter CorC
HBM78_16650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM78_16670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBM78_16675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM78_16675	COG0475	glutathione-regulated potassium exporter activity
HBM78_16680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HBM78_16690	COG0484	heat shock protein binding
HBM78_16695	COG0789	Transcriptional regulator
HBM78_16700	COG0598	Magnesium transport protein CorA
HBM78_16720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBM78_16725	COG1074	ATP-dependent DNA helicase activity
HBM78_16730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HBM78_16750	COG2226	methyltransferase
HBM78_16765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_16770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HBM78_16785	COG2111	Na H antiporter
HBM78_16785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBM78_16790	COG1006	Multisubunit Na H antiporter MnhC subunit
HBM78_16795	COG0651	ATP synthesis coupled electron transport
HBM78_16805	COG2212	antiporter activity
HBM78_16825	COG0195	Participates in both transcription termination and antitermination
HBM78_16875	COG0237	dephospho-CoA kinase activity
HBM78_16885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBM78_16900	COG0497	DNA recombination
HBM78_16910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HBM78_16940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBM78_16940	COG2169	Transcriptional regulator
HBM78_16945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBM78_17010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HBM78_17025	COG0326	Molecular chaperone. Has ATPase activity
HBM78_17040	COG2056	Na+-H+ antiporter family
HBM78_17045	COG0596	Alpha beta hydrolase
HBM78_17140	COG0546	phosphoglycolate phosphatase activity
HBM78_17145	COG1716	ATPase activity
HBM78_17190	COG0181	hydroxymethylbilane synthase activity
HBM78_17200	COG3275	phosphorelay sensor kinase activity
HBM78_17220	COG1538	Outer membrane efflux protein
HBM78_17225	COG0697	spore germination
HBM78_17250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBM78_17255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HBM78_17260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBM78_17265	COG0772	Belongs to the SEDS family
HBM78_17290	COG4974	Belongs to the 'phage' integrase family
HBM78_17295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM78_17305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBM78_17315	COG2197	response regulator
HBM78_17330	COG0793	Belongs to the peptidase S41A family
HBM78_17335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HBM78_17340	COG0795	lipopolysaccharide-transporting ATPase activity
HBM78_17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBM78_17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBM78_17390	COG0004	ammonium transporteR
HBM78_17395	COG0347	Belongs to the P(II) protein family
HBM78_17405	COG0606	chelatase, subunit chli
HBM78_17480	COG1061	Type III restriction enzyme res subunit
HBM78_17495	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_17500	COG0589	response to stress
HBM78_17545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM78_17595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBM78_17640	COG1061	Type III restriction enzyme res subunit
HBM78_17655	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_17660	COG0589	response to stress
HBM78_17690	COG0606	chelatase, subunit chli
HBM78_17705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM78_17720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBM78_17735	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_17745	COG0477	Major facilitator Superfamily
HBM78_17750	COG2860	membrane
HBM78_17760	COG1253	flavin adenine dinucleotide binding
HBM78_17780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBM78_17815	COG0655	NAD(P)H dehydrogenase (quinone) activity
HBM78_17825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBM78_17860	COG1309	transcriptional regulator
HBM78_17895	COG0758	DNA mediated transformation
HBM78_17905	COG0697	spore germination
HBM78_17910	COG1309	transcriptional regulator
HBM78_17925	COG0386	Belongs to the glutathione peroxidase family
HBM78_17990	COG1121	(ABC) transporter
HBM78_17995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBM78_18000	COG1280	lysine exporter protein (LysE YggA)
HBM78_18005	COG2837	iron assimilation
HBM78_18015	COG0281	malic enzyme
HBM78_18060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBM78_18060	COG0519	Catalyzes the synthesis of GMP from XMP
HBM78_18065	COG4399	Belongs to the UPF0754 family
HBM78_18070	COG2259	Doxx family
HBM78_18075	COG0586	Pfam SNARE associated Golgi protein
HBM78_18090	COG1192	Involved in chromosome partitioning
HBM78_18100	COG0271	Belongs to the BolA IbaG family
HBM78_18120	COG2267	carboxylic ester hydrolase activity
HBM78_18140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBM78_18140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HBM78_18140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HBM78_18140	COG3321	synthase
HBM78_18145	COG1960	acyl-CoA dehydrogenase activity
HBM78_18155	COG2197	response regulator
HBM78_18165	COG3916	Acyl-homoserine-lactone synthase
HBM78_18170	COG0477	Major facilitator Superfamily
HBM78_18175	COG1024	Enoyl-CoA hydratase
HBM78_18180	COG1024	Enoyl-CoA hydratase
HBM78_18185	COG1960	acyl-CoA dehydrogenase activity
HBM78_18190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM78_18210	COG1113	amino acid transport
HBM78_18215	COG1113	amino acid transport
HBM78_18220	COG0251	oxidation-reduction process
HBM78_18260	COG0564	pseudouridine synthase activity
HBM78_18320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HBM78_18335	COG1802	Transcriptional regulator
HBM78_18345	COG1448	Aminotransferase
HBM78_18350	COG0277	FAD linked oxidase domain protein
HBM78_18360	COG2186	Transcriptional regulator
HBM78_18370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM78_18375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBM78_18390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBM78_18395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HBM78_18400	COG1216	Glycosyl transferase, family 2
HBM78_18430	COG2089	acid synthase
HBM78_18445	COG1083	cytidylyl-transferase
HBM78_18450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HBM78_18455	COG1086	Polysaccharide biosynthesis protein
HBM78_18460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HBM78_18465	COG1596	polysaccharide export
HBM78_18490	COG0728	peptidoglycan biosynthetic process
HBM78_18495	COG3023	N-Acetylmuramoyl-L-alanine amidase
HBM78_18550	COG0546	phosphoglycolate phosphatase activity
HBM78_18555	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_18575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_18580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_18585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM78_18590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_18595	COG1116	anion transmembrane transporter activity
HBM78_18600	COG1309	transcriptional regulator
HBM78_18605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HBM78_18615	COG0196	riboflavin kinase activity
HBM78_18620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HBM78_18630	COG1047	Peptidyl-prolyl cis-trans
HBM78_18670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBM78_18725	COG2951	lytic endotransglycosylase activity
HBM78_18730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBM78_18745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBM78_18755	COG0671	phosphoesterase, PA-phosphatase related
HBM78_18760	COG0861	Integral membrane protein TerC family
HBM78_18770	COG0754	glutathionylspermidine amidase activity
HBM78_18780	COG0402	S-adenosylhomocysteine deaminase activity
HBM78_18795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM78_18800	COG1230	cation diffusion facilitator family transporter
HBM78_18815	COG0706	membrane insertase activity