locus-tag class description C5B74_00050 ENOG4105CHH sulfate transporter C5B74_00080 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C5B74_00095 ENOG4105DND Transcriptional regulator C5B74_00130 ENOG4108HWY Beta-lactamase C5B74_00170 ENOG4107QJE Chromosome Partitioning Protein C5B74_00195 ENOG4105DZR Type I site-specific deoxyribonuclease C5B74_00300 ENOG4105YES addiction module antidote protein C5B74_00305 ENOG4105VUH addiction module killer protein C5B74_00340 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C5B74_00350 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5B74_00360 ENOG4105DQR SNARE associated Golgi C5B74_00365 ENOG4105C5H ABC transporter C5B74_00370 ENOG4108821 RND type efflux pump C5B74_00375 ENOG4108821 RND type efflux pump C5B74_00380 ENOG4108821 RND type efflux pump C5B74_00390 ENOG4105D74 hydrolase C5B74_00395 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C5B74_00400 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C5B74_00445 ENOG4105C8J )-transporter C5B74_00455 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C5B74_00485 ENOG4105C2W permease C5B74_00495 ENOG4108IG5 Transcriptional regulator C5B74_00500 ENOG4105DJY efflux transporter, rnd family, mfp subunit C5B74_00535 ENOG4105F27 Major Facilitator C5B74_00540 ENOG4105CV8 reductase C5B74_00545 ENOG4105HEI LysR family (Transcriptional regulator C5B74_00565 ENOG4105DQ4 alcohol dehydrogenase C5B74_00570 ENOG4108R3E Dna-3-methyladenine glycosylase i C5B74_00585 ENOG4105CEN a g-specific adenine glycosylase C5B74_00605 ENOG4108ZZ3 UPF0260 protein C5B74_00615 ENOG4105D1H recombination factor protein RarA C5B74_00620 ENOG4105S64 Formate nitrite transporter C5B74_00640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5B74_00645 ENOG4108RWI nicotinamidase C5B74_00650 ENOG4105C09 Bile acid C5B74_00655 ENOG4107QI1 Mate efflux family protein C5B74_00660 ENOG4105EWC Purine nucleoside phosphorylase C5B74_00680 ENOG4108RXX maleylacetoacetate isomerase C5B74_00690 ENOG4105C85 amino acid C5B74_00700 ENOG4105CKI cobalamin synthesis protein C5B74_00710 ENOG4105CZE histidine utilization repressor C5B74_00715 ENOG41090B9 response to stress C5B74_00730 ENOG4105C85 amino acid C5B74_00740 ENOG41088SP formiminoglutamate hydrolase C5B74_00760 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C5B74_00765 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C5B74_00775 ENOG4108ZAI phosphatidylglycerophosphatase a C5B74_00780 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C5B74_00795 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5B74_00835 ENOG4105KHC sulfurtransferase C5B74_00865 ENOG4105BZU Histidine kinase C5B74_00870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5B74_00885 ENOG4107QJQ Mate efflux family protein C5B74_00890 ENOG4105CHM Aminotransferase C5B74_00895 ENOG4106BRA Membrane C5B74_00910 ENOG4105D9M gamma-glutamylcysteine synthetase C5B74_00920 ENOG4105CS6 Rhs element vgr protein C5B74_00945 ENOG4105IPS esterase C5B74_00950 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5B74_00955 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C5B74_00960 ENOG4108Z2U ureidoglycolate hydrolase C5B74_00970 ENOG41061H0 Monooxygenase C5B74_00985 ENOG41084YZ Hydrolase C5B74_01015 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C5B74_01020 ENOG4105BZU Histidine kinase C5B74_01035 ENOG4105KUZ arsenate reductase C5B74_01040 ENOG4105CGK Exodeoxyribonuclease III C5B74_01060 ENOG4105D7Z glutathione synthase C5B74_01080 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) C5B74_01085 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C5B74_01090 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C5B74_01105 ENOG41063SB peptidase C5B74_01110 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C5B74_01115 ENOG4107QSN dihydrolipoamide acetyltransferase C5B74_01130 ENOG4105E0K tonB-dependent siderophore receptor C5B74_01145 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C5B74_01160 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C5B74_01180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5B74_01185 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C5B74_01195 ENOG4105D64 Mechanosensitive ion channel C5B74_01205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C5B74_01210 ENOG4108W2Y isochorismatase C5B74_01220 ENOG4105D5G Transposase C5B74_01225 ENOG4105FBW Monooxygenase C5B74_01230 ENOG4108UZX fmn reductase C5B74_01245 ENOG4105BZU Histidine kinase C5B74_01250 ENOG41062QD Membrane C5B74_01255 ENOG4107QN1 sodium solute C5B74_01265 ENOG4105C94 Transporter C5B74_01275 ENOG4105BZU Histidine kinase C5B74_01285 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C5B74_01290 ENOG4108WUH Transcriptional regulator, TetR family C5B74_01295 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C5B74_01305 ENOG4105RA2 Membrane C5B74_01310 ENOG4105DWF phosphomethylpyrimidine kinase C5B74_01320 ENOG4107RDB Major Facilitator C5B74_01325 ENOG4108UUM single-stranded DNA-binding protein C5B74_01335 ENOG4108UMN azlc family C5B74_01345 ENOG4105C85 amino acid C5B74_01355 ENOG4108JPW Aminotransferase C5B74_01360 ENOG4105C26 Dehydrogenase C5B74_01370 ENOG4105CHJ isochorismatase hydrolase C5B74_01375 ENOG4105EUB pirin domain protein C5B74_01400 ENOG4105D94 Major Facilitator Superfamily C5B74_01405 ENOG4106NZI LysR family Transcriptional regulator C5B74_01425 ENOG4105CPC Aldo Keto reductase C5B74_01430 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) C5B74_01460 ENOG4105KVH Transcriptional regulator C5B74_01470 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C5B74_01535 ENOG4105CUV Homoserine Kinase C5B74_01550 ENOG41061CK Antibiotic biosynthesis monooxygenase C5B74_01580 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C5B74_01610 ENOG4105CYC Transferase C5B74_01620 ENOG4105E0F Histidine kinase C5B74_01625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5B74_01635 ENOG4105CHH sulfate transporter C5B74_01640 ENOG4105PDP Short chain dehydrogenase C5B74_01650 ENOG4105C5H ABC transporter C5B74_01735 ENOG4108IQI permease C5B74_01760 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C5B74_01775 ENOG4105CJN penicillin-binding protein C5B74_01780 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C5B74_01785 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) C5B74_01800 ENOG4105DHI Methyltransferase C5B74_01805 ENOG4108JQC penicillin-binding protein 1A C5B74_01830 ENOG4105E4G Type IV pilus C5B74_01850 ENOG4105CBC glutamate synthase C5B74_01855 ENOG4105BZ8 glutamate synthase C5B74_01865 ENOG4108V0P LemA family C5B74_01870 ENOG4105HA9 of methanol dehydrogenase type C5B74_01885 ENOG4108YSG O-Antigen polymerase C5B74_01890 ENOG4108UQY Iron-storage protein C5B74_01900 ENOG4105KME endoribonuclease L-psp C5B74_01905 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C5B74_01920 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C5B74_01970 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C5B74_01985 ENOG4107IFA Lipase (EC 3.1.1.3) C5B74_01990 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) C5B74_01995 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C5B74_02020 ENOG4108JQ1 Dehydrogenase C5B74_02025 ENOG4105CQB FAD linked oxidase domain protein C5B74_02035 ENOG4105VRH Antibiotic biosynthesis monooxygenase C5B74_02040 ENOG4105NF4 modulator of drug activity C5B74_02050 ENOG4107QF7 multi-drug C5B74_02055 ENOG4105EM2 membrane C5B74_02060 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C5B74_02065 ENOG4105IPI Membrane C5B74_02070 ENOG4107SKI cobyrinic Acid a,c-diamide synthase C5B74_02100 ENOG4108IQI permease C5B74_02105 ENOG4105D82 Glutamate dehydrogenase C5B74_02110 ENOG4105C8Y Acetylornithine aminotransferase C5B74_02120 ENOG4105C26 Dehydrogenase C5B74_02145 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5B74_02205 ENOG4105W87 Cbs domain C5B74_02210 ENOG41067S9 phage shock protein C, PspC C5B74_02220 ENOG4105CSU acyl-Coa dehydrogenase C5B74_02235 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) C5B74_02250 ENOG4105ECY inositol monophosphatase C5B74_02255 ENOG4105C1J atp-dependent rna helicase C5B74_02260 ENOG4105DHJ ABC, transporter C5B74_02265 ENOG4105CY3 ABC transporter, permease C5B74_02275 ENOG4105E3I toluene tolerance C5B74_02285 ENOG4105D7N magnesium and cobalt transport protein CorA C5B74_02290 ENOG4108URH decarboxylase C5B74_02300 ENOG4105MJ2 Competence protein C5B74_02305 ENOG4105CB5 ATP-dependent DNA helicase recG C5B74_02325 ENOG4105C29 acyl-CoA thioesterase C5B74_02330 ENOG4105CK2 sodium dicarboxylate symporter C5B74_02345 ENOG4105KPV Transcriptional regulator C5B74_02355 ENOG4105D7A ATP-binding protein C5B74_02360 ENOG4105C28 cystathionine C5B74_02365 ENOG41089BK Glutamine amido-transferase C5B74_02475 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C5B74_02480 ENOG41067V7 50S ribosomal protein L36 C5B74_02490 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C5B74_02515 ENOG4105C1G acyl-Coa dehydrogenase C5B74_02550 ENOG4105VKU nucleicacid-binding protein C5B74_02555 ENOG4105DGW oligopeptidase A C5B74_02560 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C5B74_02605 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase C5B74_02610 ENOG4108K2B transcriptional regulator C5B74_02620 ENOG4107S2Z UPF0761 membrane protein C5B74_02625 ENOG4105CS1 NAD(P)H quinone oxidoreductase C5B74_02655 ENOG4105C9A Phoh family C5B74_02665 ENOG4105E4C Lytic transglycosylase catalytic C5B74_02695 ENOG4105D6S protein involved in catabolism of external DNA C5B74_02700 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C5B74_02745 ENOG4105C1G acyl-Coa dehydrogenase C5B74_02750 ENOG4108RZE Tetr family transcriptional regulator C5B74_02765 ENOG4107QX3 carboxylase C5B74_02770 ENOG4105C1G acyl-Coa dehydrogenase C5B74_02790 ENOG4105KB2 stringent starvation protein b C5B74_02795 ENOG4107MKT Stringent starvation protein a C5B74_02800 ENOG4108UJD 30S ribosomal protein S9 C5B74_02810 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C5B74_02815 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C5B74_02820 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C5B74_02840 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C5B74_02850 ENOG4107RZC phospholipase d C5B74_02860 ENOG4105UYK outer membrane protein a C5B74_02865 ENOG4108KHX Diguanylate cyclase C5B74_02900 ENOG4107QN2 dihydrolipoyl dehydrogenase C5B74_02910 ENOG4107QPB Beta-lactamase domain protein C5B74_02915 ENOG4107U2T alpha beta C5B74_02925 ENOG4105NAU thioesterase Superfamily protein C5B74_02955 ENOG4105K9H YciI-like protein C5B74_02965 ENOG4105DB7 PHP domain protein C5B74_02970 ENOG4105FFC UPF0187 protein C5B74_02980 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C5B74_02985 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C5B74_02990 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C5B74_02995 ENOG4105VIE preprotein translocase, subunit YajC C5B74_03045 ENOG4105BZU Histidine kinase C5B74_03050 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C5B74_03055 ENOG4105CM2 brancheD-chain amino acid aminotransferase C5B74_03070 ENOG4107BJW polysaccharide deacetylase C5B74_03080 ENOG4108PQP glycosyl transferase group 1 C5B74_03120 ENOG4105UGU tonB-dependent Receptor C5B74_03140 ENOG4108VY7 phosphate-starvation-inducible protein PsiE C5B74_03145 ENOG4108K3A Glutathione S-transferase C5B74_03150 ENOG4108R4R Iron-regulated virulence regulatory protein C5B74_03155 ENOG4105CSU acyl-Coa dehydrogenase C5B74_03160 ENOG4105CSU acyl-Coa dehydrogenase C5B74_03170 ENOG4105EB3 Histidine kinase C5B74_03175 ENOG4105E3W Two component transcriptional regulator (Winged helix family C5B74_03180 ENOG4105CNG UPF0061 protein C5B74_03200 ENOG4108WBT adenosyltransferase C5B74_03215 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C5B74_03250 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C5B74_03270 ENOG4105D3R alkyl hydroperoxide reductase C5B74_03285 ENOG4105CSH Transporter C5B74_03290 ENOG4108UT2 hemolysin iii C5B74_03320 ENOG4105CHU acetyl-coa acetyltransferase C5B74_03325 ENOG4108R6W Transcriptional regulator, ARAC family C5B74_03335 ENOG4105TW1 Carbohydrate-selective porin OprB C5B74_03340 ENOG4105DZG Dehydrogenase C5B74_03345 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C5B74_03355 ENOG410814C multidrug resistance protein C5B74_03365 ENOG4105CHU acetyl-coa acetyltransferase C5B74_03375 ENOG4108WHA ompa motb domain protein C5B74_03385 ENOG4105E0Y RtcB Protein C5B74_03390 ENOG4108IQI permease C5B74_03400 ENOG4105C2W permease C5B74_03420 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C5B74_03430 ENOG4108VX5 3-methyladenine DNA glycosylase C5B74_03435 ENOG4105CHB tonB-dependent Receptor C5B74_03440 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5B74_03445 ENOG4108N2Y auxin Efflux C5B74_03455 ENOG4105T95 Thiol disulfide interChange protein C5B74_03460 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) C5B74_03470 ENOG4105K78 MarR family Transcriptional regulator C5B74_03475 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C5B74_03480 ENOG4105KWI UPF0339 protein C5B74_03505 ENOG4108UNF response regulator C5B74_03510 ENOG4105M3Z response regulator C5B74_03515 ENOG4108ZGA chew protein C5B74_03520 ENOG4105C8Q Methyl-accepting chemotaxis C5B74_03525 ENOG4105CBS Chea signal transduction histidine kinase C5B74_03540 ENOG4106HKS Entericidin EcnA/B family C5B74_03550 ENOG4105WD1 Membrane C5B74_03555 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C5B74_03595 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C5B74_03605 ENOG4105EM2 membrane C5B74_03610 ENOG4105C2C drug resistance transporter, Bcr CflA C5B74_03630 ENOG4105BZG amino acid carrier protein C5B74_03635 ENOG4105D78 K07001 NTE family protein C5B74_03640 ENOG4105C7B Threonine dehydratase C5B74_03675 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5B74_03685 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5B74_03690 ENOG4105DFF Rod shape-determining protein mreb C5B74_03695 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C5B74_03700 ENOG4105VQ7 Rod shape-determining protein MreD C5B74_03705 ENOG4108Z03 MAF-like protein C5B74_03710 ENOG4105C03 ribonuclease C5B74_03720 ENOG4105D8T Acyltransferase C5B74_03730 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein C5B74_03740 ENOG4108X0B nad(p)h dehydrogenase (quinone) C5B74_03765 ENOG4105CF7 AraC family transcriptional regulator C5B74_03785 ENOG4105C85 amino acid C5B74_03790 ENOG4105C7F AcnD-accessory protein PrpF C5B74_03795 ENOG4105CTB Polyprenyl synthetase C5B74_03800 ENOG4105MSB protein, conserved in bacteria C5B74_03815 ENOG4105D78 K07001 NTE family protein C5B74_03840 ENOG4105DIJ Phosphoethanolamine transferase C5B74_03845 ENOG4105XJC Two component transcriptional regulator (Winged helix family C5B74_03850 ENOG4105DHQ Histidine kinase C5B74_03870 ENOG4108M0I Transcriptional regulator C5B74_03890 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C5B74_03910 ENOG4105K8R UPF0145 protein C5B74_03915 ENOG4105K8R UPF0145 protein C5B74_03920 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C5B74_03925 ENOG4105BZS acriflavin resistance protein C5B74_03930 ENOG4105C1P efflux transporter, rnd family, mfp subunit C5B74_03935 ENOG410841Q phosphoesterase PA-phosphatase related protein C5B74_03965 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) C5B74_03980 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C5B74_03985 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C5B74_03990 ENOG4105KVH Transcriptional regulator C5B74_04000 ENOG4105CUB amino acid C5B74_04015 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C5B74_04020 ENOG41084BA UPF0250 protein C5B74_04025 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5B74_04060 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit C5B74_04065 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein C5B74_04075 ENOG4105E33 succinate dehydrogenase C5B74_04090 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C5B74_04095 ENOG4105C7S Dehydrogenase C5B74_04100 ENOG4107QN2 dihydrolipoyl dehydrogenase C5B74_04110 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C5B74_04120 ENOG4105CKW Inner membrane protein yedI C5B74_04125 ENOG4105CGZ zinc metallopeptidase C5B74_04130 ENOG4105EEQ Na H antiporter C5B74_04160 ENOG4105PNM synthesis protein C5B74_04175 ENOG41080TK Universal stress protein C5B74_04190 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C5B74_04195 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C5B74_04210 ENOG4105HBR Rna-binding protein C5B74_04220 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C5B74_04225 ENOG4105EEI dihydropteroate synthase C5B74_04275 ENOG4105CSH Transporter C5B74_04280 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C5B74_04285 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C5B74_04300 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C5B74_04335 ENOG41080IJ Diacylglycerol kinase C5B74_04345 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase C5B74_04350 ENOG4105BZS acriflavin resistance protein C5B74_04365 ENOG4105E4C Lytic transglycosylase catalytic C5B74_04390 ENOG4108RRZ Transcription elongation factor GreB C5B74_04405 ENOG4105CEY Amp-dependent synthetase and ligase C5B74_04450 ENOG4105BZW Glycerate kinase C5B74_04455 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit C5B74_04460 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C5B74_04475 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) C5B74_04485 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C5B74_04490 ENOG4105C85 amino acid C5B74_04500 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C5B74_04510 ENOG4105N14 lysine exporter protein LysE YggA C5B74_04515 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5B74_04520 ENOG4105BZJ Electron transfer flavoprotein C5B74_04525 ENOG4105C10 Electron transfer flavoprotein C5B74_04530 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5B74_04565 ENOG4107KET secretion protein, HlyD family C5B74_04595 ENOG4105D60 lipoprotein releasing system transmembrane protein C5B74_04600 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C5B74_04605 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C5B74_04615 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) C5B74_04620 ENOG4107R6F Alpha Beta Hydrolase Fold protein C5B74_04625 ENOG4108V3E phosphoribosylglycinamide formyltransferase C5B74_04635 ENOG4105C02 permease C5B74_04685 ENOG4105KCK Peptidoglycan-associated lipoprotein C5B74_04690 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) C5B74_04700 ENOG4105M8F Biopolymer transport protein exbD tolR C5B74_04705 ENOG4105E02 MotA TolQ exbB proton channel C5B74_04710 ENOG4107YD3 Thioesterase C5B74_04715 ENOG4105CH2 amidohydrolase C5B74_04735 ENOG4108ETH Formylglycinamide ribotide synthetase C5B74_04740 ENOG4105C2C drug resistance transporter, Bcr CflA C5B74_04745 ENOG4105EGD dinuclear metal center protein, YbgI family C5B74_04750 ENOG4108UKI Enoyl-CoA hydratase C5B74_04765 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5B74_04780 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C5B74_04785 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C5B74_04800 ENOG4107R11 Transcriptional regulator C5B74_04805 ENOG4108IJ6 ABC transporter C5B74_04815 ENOG4108I5D sulfate abc transporter C5B74_04825 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C5B74_04830 ENOG4105YAZ 4-amino-4-deoxychorismate lyase C5B74_04835 ENOG4105HHA aminodeoxychorismate lyase C5B74_04850 ENOG4108IYU L-aspartate oxidase C5B74_04855 ENOG4105C0H protease C5B74_04870 ENOG4105C3F Signal peptidase i C5B74_04885 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C5B74_04895 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) C5B74_04900 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C5B74_04905 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase C5B74_04910 ENOG4105EMU Dehydrogenase C5B74_04950 ENOG4105BZU Histidine kinase C5B74_04960 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C5B74_04970 ENOG4105DTR rard protein C5B74_05005 ENOG4107QS8 (LipO)protein C5B74_05340 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C5B74_05345 ENOG4105EA8 2-Nitropropane dioxygenase C5B74_05375 ENOG4107R8N Glycosyl transferase, family 2 C5B74_05390 ENOG4105CVP deoxyribo-dipyrimidine photolyase C5B74_05395 ENOG4108YZY peptidylprolyl cis-trans isomerase C5B74_05400 ENOG4105CEP NADH dehydrogenase C5B74_05405 ENOG4105DZ1 carboxypeptidase C5B74_05415 ENOG4105E9K Isocitrate dehydrogenase C5B74_05420 ENOG4108R99 pseudouridine synthase C5B74_05445 ENOG4105CBP Major Facilitator C5B74_05450 ENOG4105EGI Transcriptional regulator C5B74_05455 ENOG4108ETY sodium dicarboxylate symporter C5B74_05460 ENOG4105JAB phenazine biosynthesis protein, phzf family C5B74_05490 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C5B74_05505 ENOG4105D3G Pseudouridine synthase C5B74_05510 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) C5B74_05525 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C5B74_05550 ENOG4108JPW Aminotransferase C5B74_05555 ENOG4105DY8 decarboxylase C5B74_05565 ENOG4105F7P transcriptional regulator AsnC family C5B74_05570 ENOG4107RA9 decarboxylase C5B74_05575 ENOG4105C85 amino acid C5B74_05580 ENOG4105CVA phosphate C5B74_05585 ENOG4105C8U phosphate abc transporter C5B74_05595 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C5B74_05600 ENOG4105ERU peptidase C5B74_05615 ENOG4107QTF adenylosuccinate lyase C5B74_05635 ENOG4108Z0R Transferase C5B74_05640 ENOG4105DZ1 carboxypeptidase C5B74_05660 ENOG4108K5P (LipO)protein C5B74_05665 ENOG4105EJC lysr family transcriptional regulator C5B74_05670 ENOG4105DAN ATP-dependent protease C5B74_05685 ENOG4105DHU Bile acid C5B74_05705 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C5B74_05715 ENOG4105D22 carbon starvation protein C5B74_05720 ENOG4105VCD cytoplasmic protein C5B74_05755 ENOG4108K8K Transcriptional regulator C5B74_05770 ENOG4105C26 Dehydrogenase C5B74_05775 ENOG4105C85 amino acid C5B74_05780 ENOG4105ETT transcriptional Regulator, LysR family C5B74_05785 ENOG4105C94 Transporter C5B74_05790 ENOG4105C94 Transporter C5B74_05800 ENOG4105C26 Dehydrogenase C5B74_05805 ENOG4107QZF nitrite reductase NADPH large subunit C5B74_05810 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) C5B74_05840 ENOG41060M8 Pfam:PhdYeFM C5B74_05845 ENOG4107QNK )-transporter C5B74_05850 ENOG4107WEA mandelate racemase muconate lactonizing C5B74_05860 ENOG4105J7D transcriptional regulator C5B74_05880 ENOG4105C2I pirin domain protein C5B74_05890 ENOG4105WWK YheO domain protein C5B74_05905 ENOG4105CEY Amp-dependent synthetase and ligase C5B74_05920 ENOG4108IPW abc transporter atp-binding protein C5B74_05940 ENOG4105C0W non-ribosomal peptide synthetase C5B74_05945 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C5B74_05950 ENOG4105WQI isochorismatase C5B74_05965 ENOG4105BZ1 (ABC) transporter C5B74_05985 ENOG4105E4F Isochorismate synthase C5B74_06000 ENOG4105NX3 Membrane C5B74_06020 ENOG4105EUJ GTP cyclohydrolase i C5B74_06030 ENOG4105C7W Xanthine dehydrogenase C5B74_06060 ENOG4105CD8 aminopeptidase N C5B74_06065 ENOG4105DDQ anthranilate synthase C5B74_06075 ENOG4105DUX Transporter C5B74_06080 ENOG4105C5F glutamine synthetase C5B74_06090 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) C5B74_06125 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C5B74_06130 ENOG4107QNR UPF0135 protein C5B74_06135 ENOG4105C0H protease C5B74_06145 ENOG4105C6K Malic enzyme C5B74_06150 ENOG4105BZU Histidine kinase C5B74_06155 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C5B74_06160 ENOG4105SYT Methylenetetrahydrofolate reductase C5B74_06165 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C5B74_06180 ENOG4107QPN acyl-Coa dehydrogenase C5B74_06185 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C5B74_06190 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) C5B74_06200 ENOG4107RNU major facilitator superfamily MFS_1 C5B74_06210 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C5B74_06215 ENOG4105CE9 30S ribosomal protein S2 C5B74_06255 ENOG4105CVE Lytic murein transglycosylase C5B74_06260 ENOG4105CNI cell division protein FtsW C5B74_06275 ENOG4105E3A (ABC) transporter C5B74_06280 ENOG4105DA5 (ABC) transporter C5B74_06315 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C5B74_06325 ENOG4105ENT Efflux transporter rnd family, mfp subunit C5B74_06350 ENOG4105DSP amino acid AbC transporter C5B74_06355 ENOG4106YG3 ABC transporter C5B74_06360 ENOG4108JEH abc transporter atp-binding protein C5B74_06370 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C5B74_06375 ENOG4105CFP Peptidase U32 C5B74_06380 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5B74_06385 ENOG4105JAB phenazine biosynthesis protein, phzf family C5B74_06390 ENOG4105DP0 ferredoxin-NADP reductase C5B74_06395 ENOG4108R96 Methyltransferase, YaeB family C5B74_06405 ENOG4107QHF type ii secretion system protein e C5B74_06415 ENOG4105XJC Two component transcriptional regulator (Winged helix family C5B74_06420 ENOG4105DHQ Histidine kinase C5B74_06430 ENOG4105M6F mutator MutT protein C5B74_06440 ENOG4105BZ4 penicillin-binding protein C5B74_06445 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C5B74_06450 ENOG4105VUT cytoplasmic protein C5B74_06455 ENOG4107QYG anthranilate phosphoribosyltransferase C5B74_06465 ENOG4105CK2 sodium dicarboxylate symporter C5B74_06470 ENOG4105C1G acyl-Coa dehydrogenase C5B74_06475 ENOG4105NIV Esterase C5B74_06480 ENOG4105CQC Prephenate dehydratase C5B74_06485 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C5B74_06495 ENOG4105CIN aminoacyl-histidine dipeptidase C5B74_06500 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C5B74_06530 ENOG4105M08 Membrane C5B74_06535 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5B74_06545 ENOG4105VEQ Cold shock protein C5B74_06550 ENOG4105C1J atp-dependent rna helicase C5B74_06560 ENOG41069NU Nitroreductase C5B74_06595 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C5B74_06610 ENOG4105C5I Dehydrogenase C5B74_06615 ENOG4105ERG peptidase m48, ste24p C5B74_06620 ENOG4105KTH gatB Yqey C5B74_06625 ENOG4105VCC 30S ribosomal protein S21 C5B74_06650 ENOG4105D9P serine threonine protein kinase C5B74_06675 ENOG4105EVZ LysR family transcriptional regulator C5B74_06680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C5B74_06685 ENOG4105C26 Dehydrogenase C5B74_06720 ENOG4105H4F exported protein C5B74_06750 ENOG4105D6U Sodium Glutamate Symporter C5B74_06760 ENOG4105JXH GntR family transcriptional regulator C5B74_06810 ENOG4105CSH Transporter C5B74_06835 ENOG4105CEB Aspartate aminotransferase C5B74_06850 ENOG4105F1S paraquat-inducible protein a C5B74_06855 ENOG4105DY2 Paraquat-inducible protein b C5B74_06895 ENOG4105CK2 sodium dicarboxylate symporter C5B74_06905 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C5B74_06910 ENOG4108UMI ABC transporter, permease C5B74_06915 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C5B74_06925 ENOG4105C12 Phosphoribosylglycinamide synthetase C5B74_06930 ENOG4105DC1 bifunctional purine biosynthesis protein purh C5B74_06935 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) C5B74_06985 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C5B74_06990 ENOG4105CDU Replicative dna helicase C5B74_07015 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) C5B74_07020 ENOG4105CCU oxidase (Subunit III) C5B74_07025 ENOG4105BZ9 Cytochrome C oxidase, subunit I C5B74_07030 ENOG4105E2S oxidase) subunit II C5B74_07055 ENOG4107BJW polysaccharide deacetylase C5B74_07060 ENOG4105CND Glycosyl transferase, family 2 C5B74_07065 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD C5B74_07075 ENOG4105DEN Luciferase family C5B74_07095 ENOG4105CC0 LysR family Transcriptional regulator C5B74_07110 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C5B74_07115 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C5B74_07120 ENOG4105GVF (ABC) transporter C5B74_07135 ENOG4105C1G acyl-Coa dehydrogenase C5B74_07145 ENOG4108MEJ flavin reductase domain protein C5B74_07150 ENOG4105D06 uba thif-type nad fad binding protein C5B74_07170 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C5B74_07175 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C5B74_07185 ENOG4105C08 Histidine kinase C5B74_07190 ENOG4105EEX Two component transcriptional regulator (Winged helix family C5B74_07195 ENOG4105CFQ glutamine synthetase C5B74_07210 ENOG4107S74 Lysophospholipid transporter LplT C5B74_07215 ENOG4105CFU surface antigen C5B74_07235 ENOG4107QIJ Aconitate hydratase 2 C5B74_07245 ENOG4105EYW Ion transport protein C5B74_07250 ENOG4105F27 Major Facilitator C5B74_07265 ENOG4105DZ2 Transcriptional regulator C5B74_07300 ENOG4105K8N protein family UPF0079, ATPase C5B74_07305 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C5B74_07315 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C5B74_07320 ENOG4108TZV Membrane C5B74_07325 ENOG4108RCM Nitroreductase C5B74_07335 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) C5B74_07350 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C5B74_07355 ENOG4107FQ9 ethanolamine ammonia-lyase C5B74_07360 ENOG4105CPD ethanolamine ammonia-lyase C5B74_07365 ENOG4107R55 ethanolamine transporter C5B74_07375 ENOG4107RR1 TRANSCRIPTIONal C5B74_07385 ENOG4105C0A alcohol dehydrogenase C5B74_07390 ENOG4107QUV Domain protein C5B74_07400 ENOG4105F4I Transcriptional regulator C5B74_07420 ENOG4105CD8 aminopeptidase N C5B74_07430 ENOG4105EMU Dehydrogenase C5B74_07440 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) C5B74_07445 ENOG4105EW9 transcriptional regulator AsnC family C5B74_07460 ENOG4105R8C Transcriptional regulator C5B74_07470 ENOG4105CUY Mechanosensitive ion channel C5B74_07500 ENOG4105CNM Receptor C5B74_07520 ENOG4105C5H ABC transporter C5B74_07525 ENOG41081QV Universal stress protein C5B74_07540 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C5B74_07550 ENOG4105DKK Benzoate C5B74_07555 ENOG4105EW9 transcriptional regulator AsnC family C5B74_07560 ENOG4108NIW Leucine export protein LeuE C5B74_07565 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C5B74_07570 ENOG4105C5Q Transcriptional regulator C5B74_07580 ENOG4105CHU acetyl-coa acetyltransferase C5B74_07585 ENOG4105CHR reductase C5B74_07610 ENOG4107QMP dna polymerase iii subunits gamma and tau C5B74_07615 ENOG4105HSS phospholipase C C5B74_07625 ENOG4105C0A alcohol dehydrogenase C5B74_07655 ENOG4105CBC glutamate synthase C5B74_07675 ENOG4105D8G Major Facilitator superfamily C5B74_07685 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5B74_07690 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C5B74_07715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5B74_07725 ENOG4107QZF nitrite reductase NADPH large subunit C5B74_07730 ENOG4108IFG nitrite reductase, (NAD(P)H) C5B74_07750 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C5B74_07765 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C5B74_07770 ENOG4105CVM Molybdenum cofactor synthesis domain protein C5B74_07780 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5B74_07785 ENOG4105T38 integral membrane protein C5B74_07805 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) C5B74_07810 ENOG4105CMR udp-glucose 4-epimerase C5B74_07870 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C5B74_07875 ENOG4105CUX Signal transduction histidine kinase C5B74_07900 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C5B74_07905 ENOG4105KNE Phosphatidate cytidylyltransferase C5B74_07915 ENOG4105DZP Membrane-associated zinc metalloprotease C5B74_07940 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5B74_07955 ENOG4105Y3E Modulates RecA activity (By similarity) C5B74_07965 ENOG4105VEJ Heat shock protein C5B74_07970 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 C5B74_07995 ENOG4105F7P transcriptional regulator AsnC family C5B74_08005 ENOG4105C85 amino acid C5B74_08020 ENOG4105CHH sulfate transporter C5B74_08065 ENOG4105BZ1 (ABC) transporter C5B74_08120 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C5B74_08185 ENOG4105D8V Glucose sorbosone dehydrogenase C5B74_08195 ENOG4105BZU Histidine kinase C5B74_08215 ENOG4105DM4 PTS System C5B74_08220 ENOG4105DE4 1-phosphofructokinase C5B74_08225 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C5B74_08250 ENOG4105CWM branched-chain amino acid transport system II carrier protein C5B74_08255 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C5B74_08260 ENOG4105CC0 LysR family Transcriptional regulator C5B74_08270 ENOG4105M2J Glutaredoxin C5B74_08275 ENOG4105C8Y Acetylornithine aminotransferase C5B74_08280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C5B74_08305 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C5B74_08315 ENOG41068P6 UPF0319 protein C5B74_08335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C5B74_08340 ENOG4105C4M (Ubiquinol oxidase) subunit I C5B74_08350 ENOG4105PV3 Inner membrane protein yqiJ C5B74_08365 ENOG4105E0K tonB-dependent siderophore receptor C5B74_08375 ENOG4105HDD phospholipase C5B74_08380 ENOG4105CZN Potassium uptake protein C5B74_08390 ENOG4105C7B Threonine dehydratase C5B74_08420 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C5B74_08425 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C5B74_08435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C5B74_08450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5B74_08495 ENOG4107VMU Membrane C5B74_08500 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C5B74_08510 ENOG4107QP7 CoA-transferase subunit A C5B74_08515 ENOG4107QNJ CoA-transferase subunit B C5B74_08520 ENOG4105CHU acetyl-coa acetyltransferase C5B74_08525 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase C5B74_08530 ENOG4105F2Z 3-oxoadipate enol-lactonase C5B74_08535 ENOG4105D2S major facilitator superfamily C5B74_08540 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C5B74_08545 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta C5B74_08550 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha C5B74_08555 ENOG4105FF2 Type I DHQase C5B74_08560 ENOG4106JPM 3-dehydroshikimate dehydratase C5B74_08565 ENOG4105TW1 Carbohydrate-selective porin OprB C5B74_08570 ENOG4105DZG Dehydrogenase C5B74_08580 ENOG4105MD1 YeeE YedE family protein C5B74_08595 ENOG4107HP6 Transcriptional regulator C5B74_08600 ENOG4108PTX LysR family Transcriptional regulator C5B74_08605 ENOG4105C1G acyl-Coa dehydrogenase C5B74_08630 ENOG4105DNH Major Facilitator C5B74_08640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C5B74_08660 ENOG4105FUY alpha subunit C5B74_08670 ENOG4105CHR reductase C5B74_08690 ENOG4105F11 amine oxidase C5B74_08700 ENOG4105C26 Dehydrogenase C5B74_08710 ENOG4105F2Z 3-oxoadipate enol-lactonase C5B74_08715 ENOG4105CHU acetyl-coa acetyltransferase C5B74_08720 ENOG4107QNJ CoA-transferase subunit B C5B74_08725 ENOG4107QP7 CoA-transferase subunit A C5B74_08735 ENOG4105NN7 muconolactone delta-isomerase C5B74_08740 ENOG4105DTQ mandelate racemase muconate lactonizing C5B74_08745 ENOG4108KB2 LysR family Transcriptional regulator C5B74_08755 ENOG4107EJG GntR family transcriptional regulator C5B74_08775 ENOG4105CZJ Aldehyde dehydrogenase C5B74_08795 ENOG4105C1G acyl-Coa dehydrogenase C5B74_08800 ENOG4105CHR reductase C5B74_08805 ENOG4108JU7 Transcriptional regulator C5B74_08815 ENOG41062QD Membrane C5B74_08830 ENOG4107RGH Aldehyde dehydrogenase C5B74_08845 ENOG4105CH6 catalase C5B74_08870 ENOG4105K56 Transcriptional regulator C5B74_08875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5B74_08885 ENOG4105NAE bifunctional deaminase-reductase domain protein C5B74_08915 ENOG4107Z3H Transcriptional regulator, TetR family C5B74_08925 ENOG4105CHJ isochorismatase hydrolase C5B74_08930 ENOG4105EJC lysr family transcriptional regulator C5B74_08935 ENOG4105D8V Glucose sorbosone dehydrogenase C5B74_08940 ENOG4105CKD glutathione-regulated potassium-efflux system protein C5B74_08950 ENOG4105CH2 amidohydrolase C5B74_08965 ENOG4105D5K Hemolysin activator protein C5B74_08970 ENOG4105CKT filamentous hemagglutinin C5B74_09000 ENOG4105FDP GntR family transcriptional regulator C5B74_09015 ENOG4106KR7 LysR family Transcriptional regulator C5B74_09040 ENOG4108JQ1 Dehydrogenase C5B74_09045 ENOG4105JSC dimethylmenaquinone methyltransferase C5B74_09065 ENOG4105CW7 secretion protein, HlyD family C5B74_09080 ENOG4105CZJ Aldehyde dehydrogenase C5B74_09085 ENOG4105C01 Dihydroxy-acid dehydratase C5B74_09095 ENOG4105DDW LysR family Transcriptional regulator C5B74_09100 ENOG4105EXW epimerase dehydratase C5B74_09110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C5B74_09115 ENOG4105CF7 AraC family transcriptional regulator C5B74_09130 ENOG4105DQ4 alcohol dehydrogenase C5B74_09140 ENOG4105EHG Permease protein C5B74_09145 ENOG4105E0A ABC, transporter C5B74_09165 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C5B74_09245 ENOG4108UAJ Transcriptional regulator C5B74_09285 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C5B74_09340 ENOG4108BAS reductase C5B74_09355 ENOG4108R6W Transcriptional regulator, ARAC family C5B74_09360 ENOG4108821 RND type efflux pump C5B74_09365 ENOG4105E0F Histidine kinase C5B74_09370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5B74_09375 ENOG4105C1P efflux transporter, rnd family, mfp subunit C5B74_09380 ENOG4105BZS acriflavin resistance protein C5B74_09385 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C5B74_09395 ENOG4105CT3 Monooxygenase C5B74_09415 ENOG4105CJP fad dependent oxidoreductase C5B74_09435 ENOG4105X0I Fimbrial C5B74_09490 ENOG4107RZC phospholipase d C5B74_09510 ENOG4108IGT Dipeptidase C5B74_09545 ENOG4107T31 5'-nucleotidase C5B74_09555 ENOG4105WQI isochorismatase C5B74_09560 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C5B74_09565 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C5B74_09570 ENOG4105E0C molybdate abc transporter C5B74_09575 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C5B74_09580 ENOG4105F4R Transcriptional regulator mode C5B74_09585 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit C5B74_09590 ENOG4108YS2 small subunit C5B74_09595 ENOG4105F57 Anthranilate dioxygenase reductase C5B74_09620 ENOG4105CHR reductase C5B74_09630 ENOG4105D2S major facilitator superfamily C5B74_09635 ENOG4105CF7 AraC family transcriptional regulator C5B74_09645 ENOG4105DTD Dehydrogenase C5B74_09650 ENOG4105CY2 Citrate transporter C5B74_09660 ENOG4108M0I Transcriptional regulator C5B74_09670 ENOG4107QNJ CoA-transferase subunit B C5B74_09675 ENOG4105CRW Short chain fatty acid transporter C5B74_09680 ENOG4105CHU acetyl-coa acetyltransferase C5B74_09690 ENOG4107YNJ LysR family Transcriptional regulator C5B74_09705 ENOG4108IJ0 Aspartate ammonia-lyase C5B74_09715 ENOG4105CSH Transporter C5B74_09735 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C5B74_09740 ENOG4106FTQ Taurine ABC transporter, periplasmic C5B74_09755 ENOG4105FDP GntR family transcriptional regulator C5B74_09765 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5B74_09770 ENOG4105KVH Transcriptional regulator C5B74_09775 ENOG4105UEI Transcriptional Regulator AraC Family C5B74_09790 ENOG4108VCT Sulfite exporter TauE/SafE C5B74_09800 ENOG4107QPB Beta-lactamase domain protein C5B74_09810 ENOG4105FFC UPF0187 protein C5B74_09820 ENOG4105CHR reductase C5B74_09835 ENOG4105CPP Dehydrogenase, E1 component C5B74_09840 ENOG4107R0V Pyruvate dehydrogenase C5B74_09845 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C5B74_09860 ENOG4105BZU Histidine kinase C5B74_09870 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) C5B74_09875 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C5B74_09920 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C5B74_09935 ENOG4105C28 cystathionine C5B74_09945 ENOG4105F2W methyltransferase C5B74_09975 ENOG4105K59 histidine triad (HIT) protein C5B74_10000 ENOG4107QWP ABC-2 type transporter C5B74_10005 ENOG4107QWP ABC-2 type transporter C5B74_10010 ENOG4105CJ1 ABC, transporter C5B74_10025 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C5B74_10030 ENOG4105CNM Receptor C5B74_10050 ENOG4107TSN permease C5B74_10055 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C5B74_10075 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) C5B74_10080 ENOG4108YZT Adenosylcobinamide kinase C5B74_10135 ENOG4105DJU Siderophore biosynthesis protein C5B74_10140 ENOG4105DUU IucA IucC family protein C5B74_10160 ENOG4108Z66 YbaK ebsC protein C5B74_10175 ENOG4105C1G acyl-Coa dehydrogenase C5B74_10180 ENOG4105C1G acyl-Coa dehydrogenase C5B74_10185 ENOG4105EEF Alkane 1-monooxygenase C5B74_10190 ENOG4105E7U AraC family transcriptional regulator C5B74_10195 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C5B74_10200 ENOG4105K70 DNA-binding protein C5B74_10215 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C5B74_10225 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins C5B74_10230 ENOG4108Z4V iron-sulfur cluster assembly C5B74_10245 ENOG4108ZIT Ferredoxin, 2FE-2S C5B74_10250 ENOG4105F8J Adenylate Guanylate cyclase C5B74_10260 ENOG4108JA2 transcriptioN-repair coupling factor C5B74_10280 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) C5B74_10285 ENOG4105K4T epimerase C5B74_10300 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C5B74_10320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5B74_10330 ENOG4105DGW oligopeptidase A C5B74_10370 ENOG4105SG9 biopolymer transport protein, ExbD C5B74_10380 ENOG4107QP3 malate synthase g C5B74_10385 ENOG4105D6Z AFG1 family ATPase C5B74_10395 ENOG4107RN6 Monooxygenase C5B74_10415 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C5B74_10420 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C5B74_10435 ENOG4108Z6B deaminase C5B74_10455 ENOG4108RTD type II secretion system protein K C5B74_10480 ENOG4105F8V Hydrolase, tatD family C5B74_10490 ENOG4107QRG dna polymerase iii C5B74_10500 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C5B74_10505 ENOG4105BZ1 (ABC) transporter C5B74_10520 ENOG4105FA0 parb-like partition protein C5B74_10525 ENOG4107QJE Chromosome Partitioning Protein C5B74_10535 ENOG4108S0S Nucleotidyl transferase C5B74_10540 ENOG4105EHM Aminoglycoside phosphotransferase C5B74_10545 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) C5B74_10550 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C5B74_10555 ENOG4105D2N Aldolase C5B74_10575 ENOG4108UHJ MAF-like protein C5B74_10580 ENOG4105EZE Cupin 4 family protein C5B74_10590 ENOG41080HT Transcriptional regulator, arsr family C5B74_10600 ENOG4105XPP Protein of unknown function (DUF1275) C5B74_10605 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme C5B74_10610 ENOG4105BZ1 (ABC) transporter C5B74_10620 ENOG4108ZX5 transcriptional regulator C5B74_10630 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C5B74_10635 ENOG4105CK7 Sodium proline symporter C5B74_10640 ENOG4105EW9 transcriptional regulator AsnC family C5B74_10645 ENOG4105C26 Dehydrogenase C5B74_10650 ENOG4105YGK Pfam:UPF0157 C5B74_10665 ENOG4108T58 Mg2 transport protein CorA C5B74_10675 ENOG4108YYC ycei family C5B74_10685 ENOG4105CV1 Transketolase (EC 2.2.1.1) C5B74_10710 ENOG4108HWY Beta-lactamase C5B74_10730 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C5B74_10735 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C5B74_10755 ENOG4105X0I Fimbrial C5B74_10760 ENOG4105GQR Chaperone C5B74_10790 ENOG4108IPJ Membrane C5B74_10800 ENOG4105ETS cytosine purines uracil thiamine allantoin C5B74_10810 ENOG4105CC0 LysR family Transcriptional regulator C5B74_10830 ENOG41067SE Tetr family transcriptional regulator C5B74_10845 ENOG4105EW9 transcriptional regulator AsnC family C5B74_10855 ENOG4105CDA abc transporter atp-binding protein C5B74_10860 ENOG4105DRP amino acid AbC transporter C5B74_10865 ENOG4105EAD ABC transporter C5B74_10880 ENOG4107T8P acyl-Coa dehydrogenase C5B74_10895 ENOG4105D01 (LipO)protein C5B74_10900 ENOG4105D01 (LipO)protein C5B74_10905 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C5B74_10910 ENOG4108UMI ABC transporter, permease C5B74_10915 ENOG4105C3G gtp-binding protein C5B74_10940 ENOG4108UMN azlc family C5B74_10945 ENOG4105ZED uncharacterized protein ygaH C5B74_10975 ENOG4105E7U AraC family transcriptional regulator C5B74_10980 ENOG4108V06 Glutathione peroxidase C5B74_10990 ENOG4105CHM Aminotransferase C5B74_11005 ENOG4105C0B DNA polymerase III (alpha subunit) C5B74_11030 ENOG4108JU3 Alkyl hydroperoxide reductase C5B74_11045 ENOG4108KB2 LysR family Transcriptional regulator C5B74_11050 ENOG4105D6J arsenicaL-resistance protein C5B74_11055 ENOG41082YX Transcriptional regulator, arsr family C5B74_11070 ENOG4105CPN adenine deaminase C5B74_11080 ENOG4105CBN LysR family transcriptional regulator C5B74_11090 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C5B74_11100 ENOG4105E2B Taurine dioxygenase C5B74_11105 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C5B74_11110 ENOG4108IY8 ABC, transporter C5B74_11115 ENOG4106FTQ Taurine ABC transporter, periplasmic C5B74_11125 ENOG4105C54 Major Facilitator superfamily C5B74_11150 ENOG4105C4M (Ubiquinol oxidase) subunit I C5B74_11155 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C5B74_11165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5B74_11170 ENOG4108K70 Transcriptional regulator C5B74_11185 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5B74_11190 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase C5B74_11205 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) C5B74_11210 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase C5B74_11220 ENOG4105DXI Major Facilitator superfamily C5B74_11240 ENOG41067MG lrgb family C5B74_11245 ENOG4105VAW lrga family C5B74_11250 ENOG4105CMU LysR family (Transcriptional regulator C5B74_11255 ENOG4108SHQ Glutathione S-transferase C5B74_11260 ENOG4105CYM Glutathione S-transferase C5B74_11265 ENOG4105CBN LysR family transcriptional regulator C5B74_11270 ENOG4105CHR reductase C5B74_11280 ENOG4105D7W serine acetyltransferase C5B74_11285 ENOG4105ESN nucleotide-binding protein C5B74_11290 ENOG4105C9B Cysteine desulfurase C5B74_11305 ENOG4105EXG Transcriptional regulator C5B74_11315 ENOG4105CT1 (ABC) transporter C5B74_11320 ENOG4107RP9 extracellular solute-binding protein, family 3 C5B74_11325 ENOG4105CDA abc transporter atp-binding protein C5B74_11330 ENOG4108HW4 amino acid AbC transporter C5B74_11335 ENOG4105EAD ABC transporter C5B74_11350 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C5B74_11355 ENOG4105BZU Histidine kinase C5B74_11365 ENOG4105EW9 transcriptional regulator AsnC family C5B74_11375 ENOG4105KT5 UmuD protein C5B74_11395 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5B74_11440 ENOG4105HEI LysR family (Transcriptional regulator C5B74_11460 ENOG4105CEY Amp-dependent synthetase and ligase C5B74_11465 ENOG4105R8C Transcriptional regulator C5B74_11470 ENOG4105C1G acyl-Coa dehydrogenase C5B74_11475 ENOG4107QX3 carboxylase C5B74_11480 ENOG4105E39 Enoyl-CoA hydratase C5B74_11495 ENOG4105CC0 LysR family Transcriptional regulator C5B74_11510 ENOG4105CSU acyl-Coa dehydrogenase C5B74_11520 ENOG4105EQ0 Major Facilitator superfamily C5B74_11530 ENOG4107QNJ CoA-transferase subunit B C5B74_11535 ENOG4107QP7 CoA-transferase subunit A C5B74_11540 ENOG4107RGD Major Facilitator superfamily C5B74_11545 ENOG4105C1G acyl-Coa dehydrogenase C5B74_11550 ENOG4105E39 Enoyl-CoA hydratase C5B74_11555 ENOG4105CHR reductase C5B74_11560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C5B74_11565 ENOG4105CHU acetyl-coa acetyltransferase C5B74_11575 ENOG4105EQ0 Major Facilitator superfamily C5B74_11580 ENOG4105EA8 2-Nitropropane dioxygenase C5B74_11585 ENOG4108UKI Enoyl-CoA hydratase C5B74_11600 ENOG4105C1G acyl-Coa dehydrogenase C5B74_11605 ENOG4107RGD Major Facilitator superfamily C5B74_11610 ENOG4108KAZ Involved in phosphonate degradation (By similarity) C5B74_11615 ENOG4107STF Involved in phosphonate degradation (By similarity) C5B74_11625 ENOG4107RCV ABC transporter, permease C5B74_11630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C5B74_11635 ENOG4105C4Y ABC transporter C5B74_11645 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase C5B74_11650 ENOG4107HP6 Transcriptional regulator C5B74_11660 ENOG4105HEI LysR family (Transcriptional regulator C5B74_11665 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C5B74_11670 ENOG4105C26 Dehydrogenase C5B74_11680 ENOG4105ETS cytosine purines uracil thiamine allantoin C5B74_11690 ENOG4105C26 Dehydrogenase C5B74_11695 ENOG4108M8W Monooxygenase C5B74_11700 ENOG4105MXW flavin reductase domain protein, FMN-binding C5B74_11705 ENOG4108MXF Alpha Beta Hydrolase C5B74_11725 ENOG4105CPW cytochrome b561 C5B74_11730 ENOG4107VGR Catalase C5B74_11770 ENOG4107YAU phenylacetic acid degradation protein C5B74_11780 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein C5B74_11785 ENOG4105DZS Phenylacetate-CoA ligase C5B74_11790 ENOG4105CHU acetyl-coa acetyltransferase C5B74_11795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C5B74_11800 ENOG4108UKI Enoyl-CoA hydratase C5B74_11805 ENOG4105E39 Enoyl-CoA hydratase C5B74_11810 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C5B74_11815 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit C5B74_11820 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit C5B74_11825 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit C5B74_11830 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit C5B74_11835 ENOG4105DXM phenylacetic acid degradation protein C5B74_11840 ENOG4105EJQ L-serine dehydratase C5B74_11845 ENOG4107QTZ amino acid C5B74_11850 ENOG4105CZJ Aldehyde dehydrogenase C5B74_11875 ENOG4105MWK D-amino acid dehydrogenase, small subunit C5B74_11895 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5B74_11910 ENOG4108Z4X TRANSCRIPTIONal C5B74_11925 ENOG4105WPN DNA integration recombination invertion protein C5B74_11940 ENOG4105DJ2 Major Facilitator Superfamily C5B74_11945 ENOG4107Y2X deaminase C5B74_11955 ENOG4105EMY transcriptional regulator C5B74_11985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C5B74_11995 ENOG4105UYK outer membrane protein a C5B74_12070 ENOG4108HW3 (ABC) transporter C5B74_12080 ENOG4105MRR Transcriptional regulator (By similarity) C5B74_12100 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF C5B74_12105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5B74_12120 ENOG4105E2A Dehydrogenase C5B74_12130 ENOG4105R8C Transcriptional regulator C5B74_12155 ENOG4107R4J Chloride channel C5B74_12160 ENOG4108JIK carboxylase C5B74_12180 ENOG4105C5A transporter C5B74_12185 ENOG4108WAV Transcriptional regulator C5B74_12200 ENOG4105CNA YD repeat protein C5B74_12240 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) C5B74_12260 ENOG4105D2S major facilitator superfamily C5B74_12270 ENOG4105D1S lipid A biosynthesis C5B74_12275 ENOG4105BZU Histidine kinase C5B74_12280 ENOG4107AQZ Membrane C5B74_12300 ENOG4108Z4U Ferredoxin C5B74_12340 ENOG4105DFG type I secretion outer membrane protein C5B74_12345 ENOG4108IUZ ABC transporter C5B74_12350 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA C5B74_12360 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase C5B74_12365 ENOG4105C2X Arabinose 5-phosphate isomerase C5B74_12400 ENOG4107YPT transcriptional regulator C5B74_12435 ENOG4105II7 pyrroline-5-carboxylate reductase C5B74_12445 ENOG4105VEQ Cold shock protein C5B74_12450 ENOG410829K Lysine exporter protein (Lyse ygga) C5B74_12485 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5B74_12540 ENOG4108KB2 LysR family Transcriptional regulator C5B74_12545 ENOG4105FUY alpha subunit C5B74_12550 ENOG4108UKV benzoate 1,2-dioxygenase C5B74_12555 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein C5B74_12560 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase C5B74_12565 ENOG4105DKK Benzoate C5B74_12570 ENOG4105D2S major facilitator superfamily C5B74_12585 ENOG4105CQ7 ATP-dependent helicase C5B74_12590 ENOG4105D3R alkyl hydroperoxide reductase C5B74_12600 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C5B74_12610 ENOG4108JU3 Alkyl hydroperoxide reductase C5B74_12620 ENOG4108K3A Glutathione S-transferase C5B74_12630 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C5B74_12635 ENOG4108TGY Glutathione S-transferase C5B74_12645 ENOG4108ZG0 Ompa motb domain protein C5B74_12650 ENOG4105CD3 dihydroorotase C5B74_12680 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C5B74_12695 ENOG4108UKZ OsmC family C5B74_12700 ENOG4107RYR Transcriptional regulator, Crp Fnr family C5B74_12705 ENOG4105CPC Aldo Keto reductase C5B74_12720 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C5B74_12730 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C5B74_12740 ENOG4105CFH Aspartokinase C5B74_12750 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5B74_12760 ENOG4105CPW cytochrome b561 C5B74_12765 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C5B74_12770 ENOG4105C7N Xanthine uracil vitamin C permease C5B74_12780 ENOG4105F95 Monooxygenase C5B74_12945 ENOG4108C33 Resolvase C5B74_12985 ENOG4105C85 amino acid C5B74_13005 ENOG4105C26 Dehydrogenase C5B74_13025 ENOG4105CUB amino acid C5B74_13035 ENOG4105C85 amino acid C5B74_13080 ENOG4105CNA YD repeat protein C5B74_13100 ENOG4105D01 (LipO)protein C5B74_13105 ENOG4108M3P Membrane C5B74_13120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5B74_13140 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) C5B74_13160 ENOG4108JQ5 ABC transporter C5B74_13165 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component C5B74_13170 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component C5B74_13180 ENOG4105E9H Lytic Murein transglycosylase C5B74_13180 ENOG4105E9H Lytic Murein transglycosylase C5B74_13185 ENOG4107RZZ dna polymerase iii epsilon subunit C5B74_13195 ENOG4105E09 nadh pyrophosphatase C5B74_13205 ENOG4105W4M Transport-associated protein C5B74_13215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C5B74_13225 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) C5B74_13230 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C5B74_13250 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C5B74_13255 ENOG4105D0A hydroxylase C5B74_13260 ENOG4107RAQ aminopeptidase C5B74_13295 ENOG4105DIJ Phosphoethanolamine transferase C5B74_13340 ENOG4105DR5 peptidase C5B74_13665 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C5B74_13690 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C5B74_13700 ENOG4105D82 Glutamate dehydrogenase C5B74_13705 ENOG4108R3D Electron transport complex C5B74_13710 ENOG4105CSM endonuclease III C5B74_13735 ENOG4105CJN penicillin-binding protein C5B74_13740 ENOG4106H78 methyltransferase C5B74_13755 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) C5B74_13765 ENOG4105CQM Urea amidohydrolase subunit alpha C5B74_13795 ENOG4107RET Isocitrate lyase C5B74_13805 ENOG4105C37 (CBS) domain C5B74_13815 ENOG4105D4T Citrate transporter C5B74_13830 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) C5B74_13845 ENOG4108MRJ C5B74_13865 ENOG4105VCQ rubredoxin C5B74_13870 ENOG4107QZF nitrite reductase NADPH large subunit C5B74_13880 ENOG4105C5Q Transcriptional regulator C5B74_13900 ENOG4107U91 Rhomboid family C5B74_13905 ENOG4105CV6 ABC transporter, permease C5B74_13910 ENOG4108I0Y (ABC) transporter C5B74_13915 ENOG4108UJV acyl-CoA thioesterase i C5B74_13935 ENOG4107RNH Outer membrane receptor FepA C5B74_13950 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) C5B74_13955 ENOG4105E6M Sulphatase-modifying factor protein C5B74_13975 ENOG4105CJ3 phosphate transporter C5B74_13980 ENOG4105C3R Methionine synthase C5B74_13995 ENOG4105CSP Major Facilitator Superfamily C5B74_14005 ENOG4108PZW LysR family Transcriptional regulator C5B74_14020 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C5B74_14025 ENOG4105EU0 Major facilitator Superfamily C5B74_14030 ENOG4108R6W Transcriptional regulator, ARAC family C5B74_14035 ENOG4105CSV Glutaminase C5B74_14040 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C5B74_14045 ENOG4105CSH Transporter C5B74_14055 ENOG4105C7K acetolactate synthase C5B74_14070 ENOG4105CHR reductase C5B74_14075 ENOG4108MXF Alpha Beta Hydrolase C5B74_14085 ENOG4105DJB Major Facilitator Superfamily C5B74_14090 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase C5B74_14100 ENOG4105CHR reductase C5B74_14120 ENOG41069M3 Transcriptional regulator C5B74_14135 ENOG4106YT9 Enoyl-CoA hydratase C5B74_14145 ENOG4105CND Glycosyl transferase, family 2 C5B74_14150 ENOG4107BJW polysaccharide deacetylase C5B74_14160 ENOG4108VWS Yaeq family C5B74_14170 ENOG4105CKI cobalamin synthesis protein C5B74_14190 ENOG4105C94 Transporter C5B74_14195 ENOG4105C94 Transporter C5B74_14200 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) C5B74_14225 ENOG4107QK5 Homocysteine s-methyltransferase C5B74_14230 ENOG4105D5Q Arginine ornithine antiporter C5B74_14255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5B74_14260 ENOG4105C54 Major Facilitator superfamily C5B74_14320 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C5B74_14325 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5B74_14330 ENOG4105CW7 secretion protein, HlyD family C5B74_14335 ENOG4108VUY thioesterase Superfamily protein C5B74_14340 ENOG4105D52 delta-aminolevulinic acid dehydratase C5B74_14345 ENOG4105MWK D-amino acid dehydrogenase, small subunit C5B74_14350 ENOG4105ECP epimerase C5B74_14370 ENOG4107RH8 nuclease SbcCD subunit D C5B74_14375 ENOG4105EYH Exonuclease C5B74_14380 ENOG4105DFA alanine racemase domain protein C5B74_14385 ENOG4105CZX twitching motility protein C5B74_14390 ENOG4105CZX twitching motility protein C5B74_14395 ENOG41090R7 Ferric uptake C5B74_14425 ENOG4105E7A Glutamine amidotransferase C5B74_14440 ENOG4107QKV phosphomannomutase C5B74_14450 ENOG4105C4R Atp-dependent dna helicase C5B74_14455 ENOG4108ZG0 Ompa motb domain protein C5B74_14460 ENOG4106HNH Acyl-transferase C5B74_14475 ENOG4107QMS site-determining protein C5B74_14500 ENOG4105CNU cell division protein FtsK C5B74_14505 ENOG4105C3M thioredoxin reductase C5B74_14510 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) C5B74_14520 ENOG4105KEG ribosomal-protein-alanine acetyltransferase C5B74_14565 ENOG4108YXA Membrane C5B74_14570 ENOG4105EUB pirin domain protein C5B74_14580 ENOG4105C4K Nad synthetase C5B74_14595 ENOG4105E3J oxidoreductase C5B74_14600 ENOG4105C26 Dehydrogenase C5B74_14605 ENOG4105DVW rieske (2Fe-2S) C5B74_14615 ENOG4105C94 Transporter C5B74_14620 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5B74_14625 ENOG4105EJC lysr family transcriptional regulator C5B74_14645 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C5B74_14665 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C5B74_14670 ENOG4105C34 Pseudouridine synthase C5B74_14675 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C5B74_14680 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C5B74_14695 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) C5B74_14725 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C5B74_14755 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5B74_14765 ENOG4105DWF phosphomethylpyrimidine kinase C5B74_14770 ENOG4109066 lysm domain bon superfamily protein C5B74_14780 ENOG4105CHR reductase C5B74_14785 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5B74_14795 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein C5B74_14800 ENOG4108BPE -transporting atpase C5B74_14805 ENOG4107RTD sua5 ycio yrdc ywlc family protein C5B74_14810 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C5B74_14815 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C5B74_14820 ENOG4105FE9 pseudouridine synthase C5B74_14830 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C5B74_14835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C5B74_14845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C5B74_14850 ENOG4108K4C ec 3.1.3.12 C5B74_14855 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase C5B74_14860 ENOG4106UW1 Major Facilitator superfamily C5B74_14880 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C5B74_14890 ENOG4105HF0 Membrane C5B74_14905 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY C5B74_14915 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) C5B74_14975 ENOG4105D1F ATP-binding protein C5B74_14985 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C5B74_15015 ENOG4105K6H D-cysteine desulfhydrase C5B74_15020 ENOG4105CBX hi0933 family C5B74_15045 ENOG4105DP0 ferredoxin-NADP reductase C5B74_15050 ENOG4105DUM transcriptional regulator, lysR family C5B74_15070 ENOG4105C8S subunit m C5B74_15075 ENOG4105D65 subunit l C5B74_15085 ENOG4107UFS subunit j C5B74_15100 ENOG4108IEH NADH dehydrogenase subunit g C5B74_15105 ENOG4107QIZ NADH dehydrogenase C5B74_15110 ENOG4105GKE subunit e C5B74_15130 ENOG4105BZU Histidine kinase C5B74_15140 ENOG4105E0F Histidine kinase C5B74_15145 ENOG4107EXC regulatoR C5B74_15155 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C5B74_15165 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C5B74_15175 ENOG4105EB3 Histidine kinase C5B74_15255 ENOG4105DZG Dehydrogenase C5B74_15275 ENOG4105JAB phenazine biosynthesis protein, phzf family C5B74_15305 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) C5B74_15310 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C5B74_15320 ENOG4105ETT transcriptional Regulator, LysR family C5B74_15340 ENOG4105CH2 amidohydrolase C5B74_15350 ENOG4106P55 Transcriptional regulator C5B74_15370 ENOG4106P55 Transcriptional regulator C5B74_15375 ENOG4107EFR Flavocytochrome c C5B74_15385 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C5B74_15390 ENOG4107RGD Major Facilitator superfamily C5B74_15395 ENOG4105C1G acyl-Coa dehydrogenase C5B74_15400 ENOG4105ETT transcriptional Regulator, LysR family C5B74_15435 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C5B74_15440 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C5B74_15445 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5B74_15460 ENOG4105VR0 copper resistance C5B74_15465 ENOG4105E3B Multicopper oxidase C5B74_15475 ENOG4108HCJ Hydrolase C5B74_15480 ENOG4105DJV ribulose-phosphate 3-epimerase C5B74_15505 ENOG41072GX Peptidase M22 Glycoprotease C5B74_15510 ENOG4108Z0R Transferase C5B74_15555 ENOG4105CRQ synthase (Component I) C5B74_15565 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C5B74_15570 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C5B74_15575 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C5B74_15645 ENOG4105K56 Transcriptional regulator C5B74_15650 ENOG4108ZHJ Organic hydroperoxide resistance protein C5B74_15655 ENOG4107QHF type ii secretion system protein e C5B74_15675 ENOG4105C2M dna polymerase I C5B74_15680 ENOG4108VIA integral membrane protein C5B74_15685 ENOG4105II7 pyrroline-5-carboxylate reductase C5B74_15690 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C5B74_15700 ENOG4105C9X ppx gppa phosphatase C5B74_15710 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C5B74_15730 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C5B74_15755 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C5B74_15770 ENOG4105W39 Membrane C5B74_15775 ENOG4105CYM Glutathione S-transferase C5B74_15795 ENOG4105CEY Amp-dependent synthetase and ligase C5B74_15800 ENOG4105N42 UPF0307 protein C5B74_15805 ENOG41080Z8 PHOSPHOCARRIER protein C5B74_15825 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C5B74_15830 ENOG4105DJ0 Poly(A) Polymerase C5B74_15835 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein C5B74_15840 ENOG4105DXN mazG family C5B74_15850 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C5B74_15865 ENOG4105C6T cysteine synthase C5B74_15870 ENOG4105BZU Histidine kinase C5B74_15875 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase C5B74_15880 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C5B74_15885 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C5B74_15900 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C5B74_15905 ENOG4105W8H transhydrogenase (subunit alpha C5B74_15910 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C5B74_15915 ENOG4106UX7 integral membrane protein C5B74_15930 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C5B74_15940 ENOG4107RSM transcriptional regulator C5B74_15950 ENOG4105CUZ uba thif-type nad fad binding protein C5B74_15960 ENOG4107QM5 aconitate hydratase C5B74_15965 ENOG4105F8V Hydrolase, tatD family C5B74_15980 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) C5B74_16005 ENOG4105BZU Histidine kinase C5B74_16015 ENOG4108ZP8 Acetolactate synthase small subunit C5B74_16020 ENOG4105C7K acetolactate synthase C5B74_16045 ENOG4105DJY efflux transporter, rnd family, mfp subunit C5B74_16050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C5B74_16055 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C5B74_16060 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C5B74_16070 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C5B74_16075 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C5B74_16085 ENOG4105VW4 glutaredoxin 3 C5B74_16105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5B74_16110 ENOG4105C2D reductase C5B74_16120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5B74_16150 ENOG4105C84 Histidine ammonia-lyase C5B74_16165 ENOG4105CEY Amp-dependent synthetase and ligase C5B74_16180 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C5B74_16200 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C5B74_16220 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) C5B74_16240 ENOG4105WVQ Fe-S assembly protein IscX C5B74_16255 ENOG4105CN1 protease C5B74_16270 ENOG4106HB6 Alpha beta hydrolase C5B74_16280 ENOG4105C26 Dehydrogenase C5B74_16285 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family C5B74_16290 ENOG4105C6Z Gluconate C5B74_16295 ENOG4108UHU Aldolase C5B74_16300 ENOG4105C01 Dihydroxy-acid dehydratase C5B74_16305 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C5B74_16310 ENOG4108DNC Involved in acetate metabolism (By similarity) C5B74_16315 ENOG4107GFK fumarate C5B74_16335 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C5B74_16345 ENOG4108ESX Receptor C5B74_16355 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C5B74_16365 ENOG4105DWV Homoserine O-trans-acetylase C5B74_16465 ENOG4105CIY formyltetrahydrofolate deformylase C5B74_16475 ENOG4107RGH Aldehyde dehydrogenase C5B74_16480 ENOG4105KDC 50s ribosomal protein l28 C5B74_16485 ENOG4105W0E 50S ribosomal protein L33 C5B74_16490 ENOG4105CKD glutathione-regulated potassium-efflux system protein C5B74_16510 ENOG4105VFU Rna-binding protein C5B74_16515 ENOG4105C4R Atp-dependent dna helicase C5B74_16530 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C5B74_16540 ENOG4105KVH Transcriptional regulator C5B74_16550 ENOG41069P5 Protein slyX homolog C5B74_16555 ENOG4105C5H ABC transporter C5B74_16560 ENOG4105N14 lysine exporter protein LysE YggA C5B74_16565 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase C5B74_16575 ENOG4105CK2 sodium dicarboxylate symporter C5B74_16630 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5B74_16655 ENOG4105DUM transcriptional regulator, lysR family C5B74_16680 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase C5B74_16695 ENOG4108W5M transcriptional regulator C5B74_16710 ENOG4105D29 Helix-turn-helix type 11 domain protein C5B74_16715 ENOG4107XGZ Hydrolase C5B74_16720 ENOG4105EI2 Pseudouridine synthase C5B74_16730 ENOG4105C03 ribonuclease C5B74_16750 ENOG4105CBN LysR family transcriptional regulator C5B74_16755 ENOG4105EMU Dehydrogenase C5B74_16760 ENOG4105CSA Coproporphyrinogen iii oxidase C5B74_16770 ENOG4107QI1 Mate efflux family protein C5B74_16780 ENOG4107T8P acyl-Coa dehydrogenase C5B74_16825 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) C5B74_16830 ENOG4105C5X domain protein C5B74_16845 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C5B74_16855 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase C5B74_16860 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C5B74_16865 ENOG4108JU5 Magnesium and cobalt efflux protein C5B74_16870 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C5B74_16875 ENOG4108Z7R Chaperone CsaA C5B74_16885 ENOG4108VAU general secretion pathway protein G C5B74_16890 ENOG4105D7Q type ii secretion system C5B74_16895 ENOG4105C25 Primosomal protein n' C5B74_16900 ENOG4105CKD glutathione-regulated potassium-efflux system protein C5B74_16905 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C5B74_16915 ENOG4105DVC DnaJ domain protein C5B74_16920 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) C5B74_16925 ENOG4107QUT magnesium and cobalt transport protein CorA C5B74_16945 ENOG4107QYX exodeoxyribonuclease v alpha C5B74_16950 ENOG4107QKA exodeoxyribonuclease V beta C5B74_16955 ENOG4105DSY exodeoxyribonuclease V, gamma C5B74_16965 ENOG4105CSR polyphosphate kinase 2 C5B74_16985 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C5B74_17000 ENOG41061H0 Monooxygenase C5B74_17005 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C5B74_17020 ENOG4105D65 subunit l C5B74_17025 ENOG4108ZE9 Monovalent cation H antiporter subunit C C5B74_17030 ENOG4107R4Z monovalent cation h antiporter subunit d C5B74_17035 ENOG4105SC1 monovalent cation H antiporter subunit E C5B74_17040 ENOG4105W4C monovalent cation H antiporter subunit F C5B74_17045 ENOG4105KJM monovalent cation h antiporter subunit g C5B74_17060 ENOG4105CHV Transcription elongation factor NusA C5B74_17085 ENOG4107EJC Preprotein translocase subunit SecG C5B74_17095 ENOG4107QHF type ii secretion system protein e C5B74_17110 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C5B74_17120 ENOG4105C2N RNA methyltransferase TrmH family group 3 C5B74_17135 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C5B74_17145 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C5B74_17175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5B74_17180 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C5B74_17250 ENOG4107ZXU DSBA oxidoreductase C5B74_17265 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C5B74_17280 ENOG4105D3Y Na H antiporter C5B74_17285 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C5B74_17335 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C5B74_17340 ENOG4105PM1 preprotein translocase subunit SecE C5B74_17380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C5B74_17385 ENOG4105TV9 FHA Domain-Containing protein C5B74_17390 ENOG4105GVR general secretion pathway protein D C5B74_17405 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS C5B74_17430 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C5B74_17435 ENOG4108NEV two component transcriptional regulator, LytTR family C5B74_17440 ENOG4108HRK Histidine kinase C5B74_17455 ENOG4108UTW Plays a role in the regulation of phosphate uptake C5B74_17460 ENOG4105DFG type I secretion outer membrane protein C5B74_17465 ENOG4108RNG Permease of the drug metabolite transporter C5B74_17490 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C5B74_17495 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C5B74_17500 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) C5B74_17505 ENOG4105CNI cell division protein FtsW C5B74_17520 ENOG4105CE1 Ferrous iron transport protein b C5B74_17530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5B74_17535 ENOG4105T95 Thiol disulfide interChange protein C5B74_17540 ENOG4105D6E homoserine dehydrogenase C5B74_17550 ENOG41061WM D-Alanyl-D-Alanine C5B74_17560 ENOG4107TUY Histidine kinase C5B74_17565 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C5B74_17570 ENOG4105CN1 protease C5B74_17575 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C5B74_17580 ENOG4108K5H permease YjgP YjgQ family protein C5B74_17620 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C5B74_17630 ENOG4105BZU Histidine kinase C5B74_17645 ENOG4105C0P Mg chelatase subunit ChlI C5B74_17655 ENOG4108R0M Aminoglycoside C5B74_17700 ENOG4105CHH sulfate transporter C5B74_17755 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C5B74_17810 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5B74_17840 ENOG4105CHH sulfate transporter C5B74_17875 ENOG4105C0P Mg chelatase subunit ChlI C5B74_17880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5B74_17890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5B74_17900 ENOG4105EPF Outer membrane porin C5B74_17905 ENOG4105F0N pyrophosphate phospho-hydrolase C5B74_17920 ENOG4105CEY Amp-dependent synthetase and ligase C5B74_17925 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5B74_17930 ENOG41079KZ Major Facilitator Superfamily C5B74_17935 ENOG4105EN6 Membrane C5B74_17945 ENOG4105EE5 Membrane protein terC C5B74_17950 ENOG4108URH decarboxylase C5B74_17965 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5B74_17980 ENOG4105CCT upf0313 protein C5B74_18000 ENOG4105CS1 NAD(P)H quinone oxidoreductase C5B74_18010 ENOG4105C6T cysteine synthase C5B74_18045 ENOG4105Y7M Transcriptional regulator, TetR family C5B74_18080 ENOG4105C79 DNA protecting protein DprA C5B74_18095 ENOG4108IND Tetr family transcriptional regulator C5B74_18100 ENOG4107RTG Major Facilitator superfamily C5B74_18110 ENOG4108V06 Glutathione peroxidase C5B74_18150 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C5B74_18175 ENOG4105FDK ABC transporter C5B74_18180 ENOG4105FAV ABC, transporter C5B74_18190 ENOG4105EZR dyp-type peroxidase family protein C5B74_18200 ENOG4107R1I NAD-dependent malic enzyme C5B74_18225 ENOG4105EUB pirin domain protein C5B74_18245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C5B74_18250 ENOG4106MP8 UPF0754 membrane protein C5B74_18255 ENOG4108VBZ doxx family C5B74_18260 ENOG4105DQR SNARE associated Golgi C5B74_18275 ENOG4107QJE Chromosome Partitioning Protein C5B74_18285 ENOG4107PSF BolA-like protein C5B74_18305 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C5B74_18330 ENOG4105C1G acyl-Coa dehydrogenase C5B74_18355 ENOG4105CSH Transporter C5B74_18360 ENOG4105E39 Enoyl-CoA hydratase C5B74_18365 ENOG4105E39 Enoyl-CoA hydratase C5B74_18370 ENOG4105C1G acyl-Coa dehydrogenase C5B74_18380 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C5B74_18385 ENOG4105C26 Dehydrogenase C5B74_18395 ENOG4105C85 amino acid C5B74_18400 ENOG4105C85 amino acid C5B74_18405 ENOG4105M4H endoribonuclease L-psp C5B74_18420 ENOG4105EW9 transcriptional regulator AsnC family C5B74_18445 ENOG4105D3G Pseudouridine synthase C5B74_18460 ENOG4108IG5 Transcriptional regulator C5B74_18510 ENOG4108I0Z Aconitate hydratase C5B74_18515 ENOG4105BZN citrate synthase C5B74_18520 ENOG4105CR4 methylisocitrate lyase C5B74_18525 ENOG4105DRR Transcriptional regulator, GntR family C5B74_18535 ENOG4105CGF Aromatic amino acid aminotransferase C5B74_18540 ENOG4105CXG d-lactate dehydrogenase C5B74_18550 ENOG41073TP transcriptional regulator C5B74_18555 ENOG4105DAA L-lactate C5B74_18560 ENOG4107QKV phosphomannomutase C5B74_18565 ENOG4105CMR udp-glucose 4-epimerase C5B74_18575 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5B74_18580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C5B74_18590 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5B74_18595 ENOG4107WZ3 Transferase C5B74_18600 ENOG4105D3Q Sugar transferase C5B74_18610 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5B74_18625 ENOG4105K64 Glycosyl transferase, family 2 C5B74_18630 ENOG4108ZPC Polysaccharide pyruvyl transferase C5B74_18640 ENOG4107QQG Dehydrogenase C5B74_18645 ENOG4105DAY polysaccharide export protein C5B74_18655 ENOG4105D75 Capsular exopolysaccharide family C5B74_18660 ENOG4108V1T peptidylprolyl cis-trans isomerase C5B74_18665 ENOG4108V1T peptidylprolyl cis-trans isomerase C5B74_18670 ENOG4105CJR Integral membrane protein (MviN C5B74_18675 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase C5B74_18680 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C5B74_18690 ENOG4105HSS phospholipase C C5B74_18720 ENOG41062JF Transcriptional regulator C5B74_18735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C5B74_18740 ENOG4105UBK short-chain dehydrogenase reductase C5B74_18755 ENOG4107QZM n-acetylglutamate synthase C5B74_18760 ENOG4105GVF (ABC) transporter C5B74_18765 ENOG4105GVF (ABC) transporter C5B74_18770 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C5B74_18775 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C5B74_18780 ENOG4108VM9 ABC, transporter C5B74_18785 ENOG4108R86 Transcriptional regulator C5B74_18790 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C5B74_18800 ENOG4105DTN riboflavin biosynthesis protein ribF C5B74_18805 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C5B74_18815 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase C5B74_18855 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C5B74_18910 ENOG4105CVE Lytic murein transglycosylase C5B74_18915 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C5B74_18920 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C5B74_18935 ENOG4105DFU Cell wall formation (By similarity) C5B74_18945 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C5B74_18950 ENOG4105DU1 integral membrane protein, terc C5B74_18960 ENOG4106032 Glutathionylspermidine synthase C5B74_18970 ENOG4107QUY Guanine deaminase C5B74_18975 ENOG4108UGV hypoxanthine phosphoribosyltransferase C5B74_18985 ENOG4105T95 Thiol disulfide interChange protein C5B74_18990 ENOG4105PGM cation diffusion facilitator family transporter C5B74_19005 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C5B74_19020 ENOG4105VG0 50S ribosomal protein l34