locus-tag	class	description
WP4W18E11_00020	COG0592	DNA-directed DNA polymerase activity
WP4W18E11_00040	COG0187	DNA topoisomerase II activity
WP4W18E11_00060	COG0586	Pfam SNARE associated Golgi protein
WP4W18E11_00070	COG0488	(ABC) transporter
WP4W18E11_00130	COG0596	Alpha beta hydrolase
WP4W18E11_00140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP4W18E11_00150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP4W18E11_00180	COG1047	Peptidyl-prolyl cis-trans
WP4W18E11_00200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP4W18E11_00210	COG0196	riboflavin kinase activity
WP4W18E11_00230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP4W18E11_00240	COG1309	transcriptional regulator
WP4W18E11_00250	COG1116	anion transmembrane transporter activity
WP4W18E11_00260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP4W18E11_00270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP4W18E11_00280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP4W18E11_00290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP4W18E11_00330	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_00340	COG0546	phosphoglycolate phosphatase activity
WP4W18E11_00450	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP4W18E11_00460	COG0728	peptidoglycan biosynthetic process
WP4W18E11_00510	COG1596	polysaccharide export
WP4W18E11_00520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WP4W18E11_00540	COG1216	Glycosyl transferase, family 2
WP4W18E11_00540	COG1442	glycosyl transferase family 8
WP4W18E11_00550	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WP4W18E11_00550	COG1215	transferase activity, transferring glycosyl groups
WP4W18E11_00580	COG1216	Glycosyl transferase, family 2
WP4W18E11_00590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP4W18E11_00600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP4W18E11_00630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP4W18E11_00650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP4W18E11_00670	COG2186	Transcriptional regulator
WP4W18E11_00690	COG0277	FAD linked oxidase domain protein
WP4W18E11_00700	COG1448	Aminotransferase
WP4W18E11_00710	COG1802	Transcriptional regulator
WP4W18E11_00740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WP4W18E11_00800	COG0564	pseudouridine synthase activity
WP4W18E11_00880	COG0251	oxidation-reduction process
WP4W18E11_00890	COG1113	amino acid transport
WP4W18E11_00900	COG1113	amino acid transport
WP4W18E11_00940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP4W18E11_00950	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_00960	COG1024	Enoyl-CoA hydratase
WP4W18E11_00970	COG1024	Enoyl-CoA hydratase
WP4W18E11_00980	COG0477	Major facilitator Superfamily
WP4W18E11_00990	COG3916	Acyl-homoserine-lactone synthase
WP4W18E11_01010	COG2197	response regulator
WP4W18E11_01030	COG2267	carboxylic ester hydrolase activity
WP4W18E11_01050	COG0271	Belongs to the BolA IbaG family
WP4W18E11_01070	COG1192	Involved in chromosome partitioning
WP4W18E11_01100	COG0586	Pfam SNARE associated Golgi protein
WP4W18E11_01110	COG2259	Doxx family
WP4W18E11_01120	COG4399	Belongs to the UPF0754 family
WP4W18E11_01130	COG0519	Catalyzes the synthesis of GMP from XMP
WP4W18E11_01130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP4W18E11_01220	COG0281	malic enzyme
WP4W18E11_01230	COG2837	iron assimilation
WP4W18E11_01240	COG1280	lysine exporter protein (LysE YggA)
WP4W18E11_01250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP4W18E11_01260	COG1121	(ABC) transporter
WP4W18E11_01390	COG0386	Belongs to the glutathione peroxidase family
WP4W18E11_01420	COG1309	transcriptional regulator
WP4W18E11_01430	COG0697	spore germination
WP4W18E11_01450	COG0758	DNA mediated transformation
WP4W18E11_01520	COG1309	transcriptional regulator
WP4W18E11_01540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP4W18E11_01560	COG0655	NAD(P)H dehydrogenase (quinone) activity
WP4W18E11_01640	COG4452	Inner membrane protein CreD
WP4W18E11_01650	COG2205	protein histidine kinase activity
WP4W18E11_01660	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_01670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP4W18E11_01690	COG0477	Major facilitator Superfamily
WP4W18E11_01710	COG1253	flavin adenine dinucleotide binding
WP4W18E11_01730	COG2860	membrane
WP4W18E11_01740	COG0477	Major facilitator Superfamily
WP4W18E11_01760	COG0318	PFAM AMP-dependent synthetase and ligase
WP4W18E11_01790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP4W18E11_01820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP4W18E11_01840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP4W18E11_01850	COG0606	chelatase, subunit chli
WP4W18E11_01870	COG0347	Belongs to the P(II) protein family
WP4W18E11_01880	COG0004	ammonium transporteR
WP4W18E11_01900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP4W18E11_01900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP4W18E11_01980	COG0795	lipopolysaccharide-transporting ATPase activity
WP4W18E11_01990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP4W18E11_02000	COG0793	Belongs to the peptidase S41A family
WP4W18E11_02030	COG2197	response regulator
WP4W18E11_02050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP4W18E11_02070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP4W18E11_02080	COG4974	Belongs to the 'phage' integrase family
WP4W18E11_02130	COG0772	Belongs to the SEDS family
WP4W18E11_02140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP4W18E11_02150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP4W18E11_02160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WP4W18E11_02210	COG0697	spore germination
WP4W18E11_02220	COG1538	Outer membrane efflux protein
WP4W18E11_02260	COG3275	phosphorelay sensor kinase activity
WP4W18E11_02280	COG0181	hydroxymethylbilane synthase activity
WP4W18E11_02370	COG1716	ATPase activity
WP4W18E11_02380	COG0546	phosphoglycolate phosphatase activity
WP4W18E11_02530	COG0596	Alpha beta hydrolase
WP4W18E11_02540	COG2056	Na+-H+ antiporter family
WP4W18E11_02570	COG0326	Molecular chaperone. Has ATPase activity
WP4W18E11_02600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WP4W18E11_02730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP4W18E11_02740	COG2169	Transcriptional regulator
WP4W18E11_02740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP4W18E11_02800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP4W18E11_02820	COG0497	DNA recombination
WP4W18E11_02850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP4W18E11_02870	COG0237	dephospho-CoA kinase activity
WP4W18E11_02940	COG0195	Participates in both transcription termination and antitermination
WP4W18E11_02980	COG2212	antiporter activity
WP4W18E11_03000	COG0651	ATP synthesis coupled electron transport
WP4W18E11_03010	COG1006	Multisubunit Na H antiporter MnhC subunit
WP4W18E11_03020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WP4W18E11_03020	COG2111	Na H antiporter
WP4W18E11_03050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP4W18E11_03080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP4W18E11_03110	COG2226	methyltransferase
WP4W18E11_03150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP4W18E11_03160	COG1074	ATP-dependent DNA helicase activity
WP4W18E11_03170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP4W18E11_03210	COG0598	Magnesium transport protein CorA
WP4W18E11_03220	COG0789	Transcriptional regulator
WP4W18E11_03230	COG0484	heat shock protein binding
WP4W18E11_03260	COG0475	glutathione-regulated potassium exporter activity
WP4W18E11_03260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP4W18E11_03270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP4W18E11_03310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP4W18E11_03330	COG4535	Mg2 and Co2 transporter CorC
WP4W18E11_03340	COG0425	Belongs to the sulfur carrier protein TusA family
WP4W18E11_03360	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
WP4W18E11_03360	COG0644	oxidoreductase
WP4W18E11_03380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WP4W18E11_03410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP4W18E11_03420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP4W18E11_03570	COG3328	transposase activity
WP4W18E11_03590	COG2801	Transposase and inactivated derivatives
WP4W18E11_03640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP4W18E11_03670	COG0534	Mate efflux family protein
WP4W18E11_03690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP4W18E11_03700	COG4221	oxidoreductase activity
WP4W18E11_03710	COG0583	DNA-binding transcription factor activity
WP4W18E11_03720	COG0318	PFAM AMP-dependent synthetase and ligase
WP4W18E11_03730	COG1530	ribonuclease E activity
WP4W18E11_03750	COG0546	phosphoglycolate phosphatase activity
WP4W18E11_03760	COG2378	regulation of single-species biofilm formation
WP4W18E11_03770	COG0625	glutathione transferase activity
WP4W18E11_03790	COG0583	DNA-binding transcription factor activity
WP4W18E11_03800	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_03920	COG0473	3-isopropylmalate dehydrogenase activity
WP4W18E11_04030	COG1301	dicarboxylic acid transport
WP4W18E11_04050	COG1560	Kdo2-lipid A biosynthetic process
WP4W18E11_04060	COG1280	lysine exporter protein (LysE YggA)
WP4W18E11_04090	COG2900	Belongs to the SlyX family
WP4W18E11_04110	COG1733	regulation of RNA biosynthetic process
WP4W18E11_04160	COG0210	DNA helicase
WP4W18E11_04170	COG0724	RNA recognition motif
WP4W18E11_04210	COG4651	solute:proton antiporter activity
WP4W18E11_04210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP4W18E11_04260	COG0788	formyltetrahydrofolate deformylase activity
WP4W18E11_04470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP4W18E11_04470	COG2813	Specifically methylates the guanine in position
WP4W18E11_04490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP4W18E11_04510	COG4774	siderophore transport
WP4W18E11_04530	COG0740	serine-type endopeptidase activity
WP4W18E11_04570	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WP4W18E11_04570	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
WP4W18E11_04580	COG3328	transposase activity
WP4W18E11_04590	COG0857	belongs to the CobB CobQ family
WP4W18E11_04590	COG0280	phosphate acetyltransferase
WP4W18E11_04600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP4W18E11_04620	COG0800	Aldolase
WP4W18E11_04640	COG3265	gluconokinase activity
WP4W18E11_04650	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_04670	COG2267	carboxylic ester hydrolase activity
WP4W18E11_04700	COG0793	Belongs to the peptidase S41A family
WP4W18E11_04770	COG1426	Protein conserved in bacteria
WP4W18E11_04850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP4W18E11_04870	COG1162	GTPase activity
WP4W18E11_04880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP4W18E11_04910	COG1538	Outer membrane efflux protein
WP4W18E11_04920	COG0577	efflux transmembrane transporter activity
WP4W18E11_04920	COG1136	(ABC) transporter
WP4W18E11_04930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP4W18E11_04980	COG0028	Belongs to the TPP enzyme family
WP4W18E11_04990	COG0440	acetolactate synthase activity
WP4W18E11_05050	COG3501	Rhs element vgr protein
WP4W18E11_05120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP4W18E11_05210	COG4221	oxidoreductase activity
WP4W18E11_05220	COG0583	DNA-binding transcription factor activity
WP4W18E11_05250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WP4W18E11_05270	COG1979	alcohol dehydrogenase
WP4W18E11_05290	COG1902	pentaerythritol trinitrate reductase activity
WP4W18E11_05310	COG1309	transcriptional regulator
WP4W18E11_05320	COG2130	NADP-dependent
WP4W18E11_05350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WP4W18E11_05380	COG0084	hydrolase, TatD family'
WP4W18E11_05410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP4W18E11_05430	COG0583	DNA-binding transcription factor activity
WP4W18E11_05450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP4W18E11_05480	COG3328	transposase activity
WP4W18E11_05550	COG2205	protein histidine kinase activity
WP4W18E11_05580	COG2132	Multicopper oxidase
WP4W18E11_05620	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP4W18E11_05700	COG2814	Major facilitator Superfamily
WP4W18E11_05720	COG0697	spore germination
WP4W18E11_05780	COG3622	Belongs to the hyi family
WP4W18E11_05790	COG2084	Dehydrogenase
WP4W18E11_05800	COG1024	Enoyl-CoA hydratase
WP4W18E11_05810	COG5002	protein histidine kinase activity
WP4W18E11_05810	COG2205	protein histidine kinase activity
WP4W18E11_05810	COG0784	Response regulator, receiver
WP4W18E11_05850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP4W18E11_05870	COG3956	TIGRFAM MazG family protein
WP4W18E11_05880	COG1555	photosystem II stabilization
WP4W18E11_05890	COG0617	tRNA 3'-terminal CCA addition
WP4W18E11_05900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP4W18E11_05940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP4W18E11_05950	COG3028	Belongs to the UPF0307 family
WP4W18E11_05960	COG0318	PFAM AMP-dependent synthetase and ligase
WP4W18E11_05990	COG0625	glutathione transferase activity
WP4W18E11_06000	COG1238	metal cluster binding
WP4W18E11_06060	COG3328	transposase activity
WP4W18E11_06090	COG0072	phenylalanine-tRNA ligase activity
WP4W18E11_06140	COG0248	Ppx GppA phosphatase
WP4W18E11_06160	COG0037	tRNA processing
WP4W18E11_06240	COG1764	response to oxidative stress
WP4W18E11_06250	COG1846	Transcriptional regulator
WP4W18E11_06270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP4W18E11_06340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP4W18E11_06350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP4W18E11_06360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP4W18E11_06380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP4W18E11_06480	COG1214	PFAM Peptidase M22, glycoprotease
WP4W18E11_06510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WP4W18E11_06530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP4W18E11_06540	COG0561	phosphatase activity
WP4W18E11_06560	COG2132	Multicopper oxidase
WP4W18E11_06570	COG2132	Multicopper oxidase
WP4W18E11_06610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP4W18E11_06620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
WP4W18E11_06630	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP4W18E11_06640	COG2814	Major facilitator Superfamily
WP4W18E11_06650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WP4W18E11_06660	COG2801	Transposase and inactivated derivatives
WP4W18E11_06690	COG1053	succinate dehydrogenase
WP4W18E11_06700	COG0583	DNA-binding transcription factor activity
WP4W18E11_06730	COG0583	DNA-binding transcription factor activity
WP4W18E11_06750	COG1473	amidohydrolase
WP4W18E11_06790	COG0583	DNA-binding transcription factor activity
WP4W18E11_06820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP4W18E11_06860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP4W18E11_06890	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_06900	COG2205	protein histidine kinase activity
WP4W18E11_06970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WP4W18E11_07030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WP4W18E11_07040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP4W18E11_07080	COG0583	DNA-binding transcription factor activity
WP4W18E11_07120	COG0668	transmembrane transport
WP4W18E11_07140	COG2081	HI0933 family
WP4W18E11_07150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WP4W18E11_07210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP4W18E11_07210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP4W18E11_07230	COG0489	protein tyrosine kinase activity
WP4W18E11_07260	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_07350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP4W18E11_07370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP4W18E11_07400	COG0730	response to heat
WP4W18E11_07420	COG1196	nuclear chromosome segregation
WP4W18E11_07450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP4W18E11_07460	COG1002	Type II restriction enzyme, methylase subunits
WP4W18E11_07470	COG1061	Type III restriction enzyme res subunit
WP4W18E11_07490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WP4W18E11_07530	COG3621	Patatin-like phospholipase
WP4W18E11_07640	COG2223	nitrite transmembrane transporter activity
WP4W18E11_07650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WP4W18E11_07660	COG1877	trehalose-phosphatase activity
WP4W18E11_07670	COG0596	Alpha beta hydrolase
WP4W18E11_07670	COG2226	methyltransferase
WP4W18E11_07670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP4W18E11_07700	COG4106	trans-aconitate 2-methyltransferase activity
WP4W18E11_07730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP4W18E11_07740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WP4W18E11_07750	COG0009	L-threonylcarbamoyladenylate synthase
WP4W18E11_07760	COG3101	peptidyl-lysine hydroxylation
WP4W18E11_07770	COG1399	metal-binding, possibly nucleic acid-binding protein
WP4W18E11_07820	COG1652	LysM domain
WP4W18E11_07830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WP4W18E11_07830	COG0351	phosphomethylpyrimidine kinase
WP4W18E11_07830	COG0352	thiamine-phosphate diphosphorylase activity
WP4W18E11_07850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP4W18E11_07910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP4W18E11_07930	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP4W18E11_07960	COG0358	DNA primase activity
WP4W18E11_07980	COG0564	pseudouridine synthase activity
WP4W18E11_08390	COG0582	viral genome integration into host DNA
WP4W18E11_08410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP4W18E11_08430	COG0583	DNA-binding transcription factor activity
WP4W18E11_08440	COG0473	3-isopropylmalate dehydrogenase activity
WP4W18E11_08480	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_08510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP4W18E11_08510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP4W18E11_08630	COG0456	acetyltransferase
WP4W18E11_08650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP4W18E11_08660	COG0492	ferredoxin-NADP+ reductase activity
WP4W18E11_08670	COG1674	ftsk spoiiie
WP4W18E11_08680	COG1280	lysine exporter protein (LysE YggA)
WP4W18E11_08720	COG2894	cell division
WP4W18E11_08750	COG0204	Acyl-transferase
WP4W18E11_08760	COG2885	chlorophyll binding
WP4W18E11_08780	COG0210	DNA helicase
WP4W18E11_08800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP4W18E11_08830	COG0121	glutamine amidotransferase
WP4W18E11_08840	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_08880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP4W18E11_08890	COG0735	belongs to the Fur family
WP4W18E11_08940	COG0420	3'-5' exonuclease activity
WP4W18E11_08980	COG1090	epimerase
WP4W18E11_09010	COG2050	protein possibly involved in aromatic compounds catabolism
WP4W18E11_09030	COG2814	Major facilitator Superfamily
WP4W18E11_09040	COG0405	Gamma-glutamyltransferase
WP4W18E11_09050	COG0582	viral genome integration into host DNA
WP4W18E11_09160	COG0500	methyltransferase
WP4W18E11_09160	COG3615	Tellurite resistance protein tehB
WP4W18E11_09200	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP4W18E11_09220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP4W18E11_09250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP4W18E11_09280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP4W18E11_09310	COG1360	Flagellar Motor Protein
WP4W18E11_09330	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_09350	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_09530	COG2814	Major facilitator Superfamily
WP4W18E11_09560	COG1230	cation diffusion facilitator family transporter
WP4W18E11_09590	COG0582	viral genome integration into host DNA
WP4W18E11_09620	COG3177	Filamentation induced by cAMP protein fic
WP4W18E11_09630	COG0582	viral genome integration into host DNA
WP4W18E11_09740	COG0477	Major facilitator Superfamily
WP4W18E11_09750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP4W18E11_09770	COG1595	DNA-templated transcription, initiation
WP4W18E11_09880	COG0531	amino acid
WP4W18E11_09890	COG2040	homocysteine
WP4W18E11_09940	COG1309	transcriptional regulator
WP4W18E11_09950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP4W18E11_09960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP4W18E11_09980	COG1607	acyl-coa hydrolase
WP4W18E11_10000	COG0523	cobalamin synthesis protein
WP4W18E11_10020	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_10030	COG1301	dicarboxylic acid transport
WP4W18E11_10040	COG4681	YaeQ
WP4W18E11_10060	COG1649	PFAM Uncharacterised BCR, COG1649
WP4W18E11_10060	COG0726	polysaccharide deacetylase
WP4W18E11_10070	COG1215	transferase activity, transferring glycosyl groups
WP4W18E11_10090	COG1024	Enoyl-CoA hydratase
WP4W18E11_10120	COG1414	Transcriptional regulator
WP4W18E11_10160	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_10190	COG2271	Major facilitator Superfamily
WP4W18E11_10210	COG2267	carboxylic ester hydrolase activity
WP4W18E11_10220	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_10250	COG0028	Belongs to the TPP enzyme family
WP4W18E11_10270	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_10290	COG0477	Major facilitator Superfamily
WP4W18E11_10300	COG0242	peptide deformylase activity
WP4W18E11_10310	COG2066	Belongs to the glutaminase family
WP4W18E11_10320	COG2207	Transcriptional regulator
WP4W18E11_10330	COG2223	nitrite transmembrane transporter activity
WP4W18E11_10360	COG0583	DNA-binding transcription factor activity
WP4W18E11_10370	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_10380	COG2271	Major facilitator Superfamily
WP4W18E11_10390	COG3959	Transketolase, thiamine diphosphate binding domain
WP4W18E11_10400	COG3958	Transketolase
WP4W18E11_10410	COG3958	Transketolase
WP4W18E11_10430	COG0306	phosphate transporter
WP4W18E11_10470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP4W18E11_10560	COG4181	ATPase activity
WP4W18E11_10570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP4W18E11_10620	COG0583	DNA-binding transcription factor activity
WP4W18E11_10640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP4W18E11_10650	COG1773	rubredoxin
WP4W18E11_10750	COG2851	Citrate transporter
WP4W18E11_10760	COG1253	flavin adenine dinucleotide binding
WP4W18E11_10840	COG0804	urea catabolic process
WP4W18E11_10860	COG0830	nickel cation binding
WP4W18E11_10890	COG0742	ribosomal rna small subunit methyltransferase
WP4W18E11_10900	COG0768	penicillin binding
WP4W18E11_10940	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP4W18E11_10950	COG2878	Part of a membrane complex involved in electron transport
WP4W18E11_10960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP4W18E11_10980	COG3384	dioxygenase
WP4W18E11_11010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP4W18E11_11080	COG0006	proline dipeptidase activity
WP4W18E11_11090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP4W18E11_11100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP4W18E11_11140	COG1279	arginine transmembrane transporter activity
WP4W18E11_11150	COG0583	DNA-binding transcription factor activity
WP4W18E11_11230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP4W18E11_11240	COG1388	LysM domain
WP4W18E11_11240	COG0741	lytic transglycosylase activity
WP4W18E11_11240	COG1388	LysM domain
WP4W18E11_11240	COG0741	lytic transglycosylase activity
WP4W18E11_11260	COG4174	ABC transporter (Permease)
WP4W18E11_11270	COG4239	(ABC) transporter, permease
WP4W18E11_11280	COG4172	Belongs to the ABC transporter superfamily
WP4W18E11_11310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP4W18E11_11330	COG4251	negative regulation of phosphorylation
WP4W18E11_11330	COG3706	GGDEF domain
WP4W18E11_11330	COG2203	Gaf domain
WP4W18E11_11330	COG5001	Diguanylate cyclase
WP4W18E11_11360	COG1902	pentaerythritol trinitrate reductase activity
WP4W18E11_11360	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP4W18E11_11400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP4W18E11_11410	COG3328	transposase activity
WP4W18E11_11430	COG0583	DNA-binding transcription factor activity
WP4W18E11_11440	COG2814	Major facilitator Superfamily
WP4W18E11_11470	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_11480	COG1454	alcohol dehydrogenase
WP4W18E11_11490	COG3485	protocatechuate 3,4-dioxygenase
WP4W18E11_11520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP4W18E11_11530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP4W18E11_11540	COG0183	Belongs to the thiolase family
WP4W18E11_11610	COG1113	amino acid transport
WP4W18E11_11630	COG0531	amino acid
WP4W18E11_11670	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_11710	COG1113	amino acid transport
WP4W18E11_11740	COG0697	spore germination
WP4W18E11_11750	COG2721	sulfolactate sulfo-lyase activity
WP4W18E11_11760	COG2271	Major facilitator Superfamily
WP4W18E11_11770	COG4948	Mandelate Racemase Muconate Lactonizing
WP4W18E11_11790	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_11800	COG2186	Transcriptional regulator
WP4W18E11_11850	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_11870	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_11880	COG1024	Enoyl-CoA hydratase
WP4W18E11_11890	COG2814	Major facilitator Superfamily
WP4W18E11_11920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP4W18E11_11950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP4W18E11_12040	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
WP4W18E11_12070	COG0583	DNA-binding transcription factor activity
WP4W18E11_12080	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
WP4W18E11_12090	COG2072	flavoprotein involved in K transport
WP4W18E11_12100	COG0300	oxidoreductase activity
WP4W18E11_12120	COG1309	transcriptional regulator
WP4W18E11_12130	COG1741	Belongs to the pirin family
WP4W18E11_12160	COG2072	flavoprotein involved in K transport
WP4W18E11_12180	COG2252	PERMEase
WP4W18E11_12190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP4W18E11_12200	COG2801	Transposase and inactivated derivatives
WP4W18E11_12220	COG3038	cytochrome b561
WP4W18E11_12240	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP4W18E11_12260	COG0527	aspartate kinase activity
WP4W18E11_12280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP4W18E11_12300	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WP4W18E11_12330	COG0667	Aldo Keto reductase
WP4W18E11_12350	COG1765	OsmC-like protein
WP4W18E11_12370	COG3328	transposase activity
WP4W18E11_12390	COG0542	response to heat
WP4W18E11_12460	COG2885	chlorophyll binding
WP4W18E11_12480	COG0625	glutathione transferase activity
WP4W18E11_12490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP4W18E11_12530	COG3634	alkyl hydroperoxide reductase activity
WP4W18E11_12550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP4W18E11_12570	COG0450	alkyl hydroperoxide reductase
WP4W18E11_12580	COG1643	Atp-dependent helicase
WP4W18E11_12610	COG2814	Major facilitator Superfamily
WP4W18E11_12620	COG3135	benzoate transporter
WP4W18E11_12630	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_12640	COG0633	Ferredoxin
WP4W18E11_12640	COG0543	2 iron, 2 sulfur cluster binding
WP4W18E11_12650	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
WP4W18E11_12660	COG4638	Rieske (2fe-2S)
WP4W18E11_12670	COG0583	DNA-binding transcription factor activity
WP4W18E11_12690	COG2871	sodium ion transport
WP4W18E11_12860	COG1570	exodeoxyribonuclease VII activity
WP4W18E11_12920	COG1280	lysine exporter protein (LysE YggA)
WP4W18E11_12930	COG1278	Cold shock
WP4W18E11_13000	COG2814	Major facilitator Superfamily
WP4W18E11_13070	COG0517	IMP dehydrogenase activity
WP4W18E11_13070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP4W18E11_13080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP4W18E11_13100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP4W18E11_13110	COG1137	ATPase activity
WP4W18E11_13120	COG1538	Outer membrane efflux protein
WP4W18E11_13180	COG4122	O-methyltransferase activity
WP4W18E11_13200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP4W18E11_13230	COG1522	sequence-specific DNA binding
WP4W18E11_13240	COG5006	permease, DMT superfamily
WP4W18E11_13260	COG1560	Kdo2-lipid A biosynthetic process
WP4W18E11_13280	COG2801	Transposase and inactivated derivatives
WP4W18E11_13310	COG2814	Major facilitator Superfamily
WP4W18E11_13350	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP4W18E11_13390	COG0583	DNA-binding transcription factor activity
WP4W18E11_13400	COG1914	H( )-stimulated, divalent metal cation uptake system
WP4W18E11_13440	COG4770	biotin carboxylase activity
WP4W18E11_13450	COG0038	chloride channel
WP4W18E11_13470	COG1309	transcriptional regulator
WP4W18E11_13490	COG1063	alcohol dehydrogenase
WP4W18E11_13520	COG0439	Biotin carboxylase
WP4W18E11_13530	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP4W18E11_13540	COG1733	regulation of RNA biosynthetic process
WP4W18E11_13560	COG0864	Transcriptional regulator
WP4W18E11_13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP4W18E11_13590	COG1116	anion transmembrane transporter activity
WP4W18E11_13610	COG3328	transposase activity
WP4W18E11_13650	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WP4W18E11_13670	COG0789	Transcriptional regulator
WP4W18E11_13700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP4W18E11_13740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP4W18E11_13790	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_13800	COG0531	amino acid
WP4W18E11_13810	COG1760	l-serine dehydratase
WP4W18E11_13820	COG2030	dehydratase
WP4W18E11_13820	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_13830	COG3396	Phenylacetate-CoA oxygenase
WP4W18E11_13840	COG3460	Phenylacetate-CoA oxygenase
WP4W18E11_13850	COG3396	Phenylacetate-CoA oxygenase
WP4W18E11_13860	COG2151	metal-sulfur cluster biosynthetic enzyme
WP4W18E11_13870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP4W18E11_13880	COG1024	Enoyl-CoA hydratase
WP4W18E11_13890	COG1024	Enoyl-CoA hydratase
WP4W18E11_13900	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP4W18E11_13910	COG0183	Belongs to the thiolase family
WP4W18E11_13920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
WP4W18E11_13930	COG3327	negative regulation of DNA-templated transcription, initiation
WP4W18E11_13950	COG2050	protein possibly involved in aromatic compounds catabolism
WP4W18E11_13980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP4W18E11_13990	COG2271	Major facilitator Superfamily
WP4W18E11_14000	COG0753	catalase activity
WP4W18E11_14010	COG3038	cytochrome b561
WP4W18E11_14050	COG2267	carboxylic ester hydrolase activity
WP4W18E11_14060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP4W18E11_14070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP4W18E11_14080	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_14090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP4W18E11_14110	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_14120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP4W18E11_14130	COG0583	DNA-binding transcription factor activity
WP4W18E11_14150	COG1414	Transcriptional regulator
WP4W18E11_14160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP4W18E11_14180	COG1840	ABC-type Fe3 transport system, periplasmic component
WP4W18E11_14190	COG3842	ATPase activity
WP4W18E11_14220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WP4W18E11_14230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP4W18E11_14240	COG2814	Major facilitator Superfamily
WP4W18E11_14250	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_14260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WP4W18E11_14280	COG1024	Enoyl-CoA hydratase
WP4W18E11_14300	COG2814	Major facilitator Superfamily
WP4W18E11_14320	COG0183	Belongs to the thiolase family
WP4W18E11_14330	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP4W18E11_14340	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_14350	COG1024	Enoyl-CoA hydratase
WP4W18E11_14360	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_14370	COG2814	Major facilitator Superfamily
WP4W18E11_14380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP4W18E11_14390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP4W18E11_14410	COG2814	Major facilitator Superfamily
WP4W18E11_14430	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_14460	COG0583	DNA-binding transcription factor activity
WP4W18E11_14480	COG4770	biotin carboxylase activity
WP4W18E11_14490	COG1024	Enoyl-CoA hydratase
WP4W18E11_14500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP4W18E11_14510	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_14520	COG1309	transcriptional regulator
WP4W18E11_14530	COG0318	PFAM AMP-dependent synthetase and ligase
WP4W18E11_14570	COG0583	DNA-binding transcription factor activity
WP4W18E11_14610	COG2801	Transposase and inactivated derivatives
WP4W18E11_14700	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_14740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP4W18E11_14780	COG2205	protein histidine kinase activity
WP4W18E11_14780	COG0784	Response regulator, receiver
WP4W18E11_14850	COG0765	amino acid transport
WP4W18E11_14860	COG0765	amino acid transport
WP4W18E11_14880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP4W18E11_14890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP4W18E11_14910	COG1280	lysine exporter protein (LysE YggA)
WP4W18E11_14920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP4W18E11_14930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP4W18E11_14940	COG1045	serine acetyltransferase
WP4W18E11_14970	COG0583	DNA-binding transcription factor activity
WP4W18E11_14980	COG0625	glutathione transferase activity
WP4W18E11_14990	COG0625	glutathione transferase activity
WP4W18E11_15000	COG0583	DNA-binding transcription factor activity
WP4W18E11_15020	COG1346	cytolysis
WP4W18E11_15070	COG0300	oxidoreductase activity
WP4W18E11_15100	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
WP4W18E11_15110	COG3052	prosthetic group binding
WP4W18E11_15150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WP4W18E11_15190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP4W18E11_15210	COG1294	oxidase, subunit
WP4W18E11_15220	COG1271	oxidase subunit
WP4W18E11_15260	COG0477	Major facilitator Superfamily
WP4W18E11_15280	COG4521	taurine ABC transporter
WP4W18E11_15290	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WP4W18E11_15300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP4W18E11_15310	COG2175	clavaminate synthase activity
WP4W18E11_15330	COG1953	Uracil, thiamine, allantoin
WP4W18E11_15350	COG0583	DNA-binding transcription factor activity
WP4W18E11_15370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WP4W18E11_15400	COG0640	Transcriptional regulator
WP4W18E11_15410	COG0798	PFAM Bile acid sodium symporter
WP4W18E11_15420	COG0583	DNA-binding transcription factor activity
WP4W18E11_15450	COG3634	alkyl hydroperoxide reductase activity
WP4W18E11_15520	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_15530	COG1301	dicarboxylic acid transport
WP4W18E11_15540	COG3328	transposase activity
WP4W18E11_15550	COG1301	dicarboxylic acid transport
WP4W18E11_15560	COG0436	Aminotransferase
WP4W18E11_15580	COG0386	Belongs to the glutathione peroxidase family
WP4W18E11_15660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WP4W18E11_15720	COG0012	GTP binding
WP4W18E11_15730	COG2011	ABC-type metal ion transport system permease component
WP4W18E11_15740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP4W18E11_15750	COG1464	Belongs to the NlpA lipoprotein family
WP4W18E11_15760	COG1464	Belongs to the NlpA lipoprotein family
WP4W18E11_15820	COG0765	amino acid transport
WP4W18E11_15830	COG0765	amino acid transport
WP4W18E11_15840	COG1126	abc transporter atp-binding protein
WP4W18E11_15870	COG1522	sequence-specific DNA binding
WP4W18E11_15900	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_15910	COG1309	transcriptional regulator
WP4W18E11_15960	COG0583	DNA-binding transcription factor activity
WP4W18E11_15980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP4W18E11_16000	COG0697	spore germination
WP4W18E11_16080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP4W18E11_16080	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP4W18E11_16170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP4W18E11_16190	COG2353	YceI-like domain
WP4W18E11_16210	COG3698	Phosphodiester glycosidase
WP4W18E11_16240	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
WP4W18E11_16250	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP4W18E11_16250	COG0506	proline dehydrogenase activity
WP4W18E11_16250	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP4W18E11_16270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP4W18E11_16280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WP4W18E11_16320	COG1132	(ABC) transporter
WP4W18E11_16330	COG3122	Protein conserved in bacteria
WP4W18E11_16340	COG3619	membrane
WP4W18E11_16360	COG0640	Transcriptional regulator
WP4W18E11_16380	COG2850	peptidyl-arginine hydroxylation
WP4W18E11_16390	COG0424	maF-like protein
WP4W18E11_16430	COG0191	fructose-bisphosphate aldolase activity
WP4W18E11_16440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP4W18E11_16470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP4W18E11_16490	COG1192	Involved in chromosome partitioning
WP4W18E11_16500	COG1475	DNA binding
WP4W18E11_16510	COG0811	peptide transport
WP4W18E11_16530	COG1132	(ABC) transporter
WP4W18E11_16540	COG1663	tetraacyldisaccharide 4'-kinase activity
WP4W18E11_16580	COG0084	hydrolase, TatD family'
WP4W18E11_16670	COG0590	tRNA wobble adenosine to inosine editing
WP4W18E11_16710	COG0776	regulation of translation
WP4W18E11_16770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP4W18E11_16780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP4W18E11_16870	COG0339	signal peptide processing
WP4W18E11_16890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP4W18E11_16960	COG0702	epimerase
WP4W18E11_16970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP4W18E11_17010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP4W18E11_17070	COG0316	Belongs to the HesB IscA family
WP4W18E11_17080	COG0822	iron-sulfur transferase activity
WP4W18E11_17130	COG0776	regulation of translation
WP4W18E11_17140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP4W18E11_17150	COG2207	Transcriptional regulator
WP4W18E11_17160	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP4W18E11_17170	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_17180	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_17210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP4W18E11_17240	COG2814	Major facilitator Superfamily
WP4W18E11_17250	COG4264	IucA IucC family
WP4W18E11_17260	COG4264	IucA IucC family
WP4W18E11_17280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP4W18E11_17340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP4W18E11_17370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
WP4W18E11_17380	COG0406	alpha-ribazole phosphatase activity
WP4W18E11_17410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP4W18E11_17420	COG0730	response to heat
WP4W18E11_17460	COG4773	Receptor
WP4W18E11_17470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP4W18E11_17500	COG1131	(ABC) transporter
WP4W18E11_17510	COG0842	Transport permease protein
WP4W18E11_17520	COG0842	Transport permease protein
WP4W18E11_17630	COG2226	methyltransferase
WP4W18E11_17680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP4W18E11_17750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP4W18E11_17770	COG0133	tryptophan synthase activity
WP4W18E11_17800	COG3706	GGDEF domain
WP4W18E11_17830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP4W18E11_17840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WP4W18E11_17850	COG0022	dehydrogenase e1 component
WP4W18E11_17860	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP4W18E11_17870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP4W18E11_17890	COG1063	alcohol dehydrogenase
WP4W18E11_17900	COG3781	membrane
WP4W18E11_17920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP4W18E11_17920	COG3453	Protein conserved in bacteria
WP4W18E11_17940	COG0730	response to heat
WP4W18E11_17970	COG2207	Transcriptional regulator
WP4W18E11_17970	COG3708	Transcriptional regulator
WP4W18E11_17980	COG1733	regulation of RNA biosynthetic process
WP4W18E11_17990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP4W18E11_18010	COG2188	Transcriptional regulator
WP4W18E11_18040	COG4521	taurine ABC transporter
WP4W18E11_18050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP4W18E11_18090	COG0477	Major facilitator Superfamily
WP4W18E11_18110	COG1027	Aspartate ammonia-lyase
WP4W18E11_18140	COG0583	DNA-binding transcription factor activity
WP4W18E11_18150	COG0583	DNA-binding transcription factor activity
WP4W18E11_18160	COG0183	Belongs to the thiolase family
WP4W18E11_18170	COG2031	fatty acid transporter
WP4W18E11_18200	COG0583	DNA-binding transcription factor activity
WP4W18E11_18240	COG1309	transcriptional regulator
WP4W18E11_18260	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_18270	COG2610	gluconate transmembrane transporter activity
WP4W18E11_18280	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_18310	COG2207	Transcriptional regulator
WP4W18E11_18340	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_18360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP4W18E11_18390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP4W18E11_18390	COG0543	2 iron, 2 sulfur cluster binding
WP4W18E11_18400	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
WP4W18E11_18410	COG4638	Rieske (2fe-2S)
WP4W18E11_18430	COG0725	ABC transporter, periplasmic molybdate-binding protein
WP4W18E11_18440	COG4149	molybdate abc transporter
WP4W18E11_18450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP4W18E11_18460	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_18470	COG3433	isochorismatase activity
WP4W18E11_18470	COG1535	isochorismatase
WP4W18E11_18590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP4W18E11_18620	COG0753	catalase activity
WP4W18E11_18650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WP4W18E11_18860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP4W18E11_18900	COG2072	flavoprotein involved in K transport
WP4W18E11_18950	COG3328	transposase activity
WP4W18E11_18960	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_19000	COG2801	Transposase and inactivated derivatives
WP4W18E11_19050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP4W18E11_19110	COG3220	belongs to the UPF0276 family
WP4W18E11_19140	COG1595	DNA-templated transcription, initiation
WP4W18E11_19250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP4W18E11_19290	COG1120	ATPase activity
WP4W18E11_19350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP4W18E11_19360	COG0583	DNA-binding transcription factor activity
WP4W18E11_19380	COG0129	dihydroxy-acid dehydratase activity
WP4W18E11_19410	COG2186	Transcriptional regulator
WP4W18E11_19430	COG0583	DNA-binding transcription factor activity
WP4W18E11_19440	COG4948	Mandelate Racemase Muconate Lactonizing
WP4W18E11_19450	COG4829	muconolactone delta-isomerase
WP4W18E11_19470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP4W18E11_19480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP4W18E11_19490	COG0183	Belongs to the thiolase family
WP4W18E11_19500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP4W18E11_19510	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_19530	COG3733	amine oxidase
WP4W18E11_19550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP4W18E11_19570	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_19590	COG4638	Rieske (2fe-2S)
WP4W18E11_19630	COG0154	amidase activity
WP4W18E11_19650	COG2814	Major facilitator Superfamily
WP4W18E11_19700	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_19710	COG0583	DNA-binding transcription factor activity
WP4W18E11_19720	COG1414	Transcriptional regulator
WP4W18E11_19750	COG2391	methyltransferase activity
WP4W18E11_19770	COG4993	Dehydrogenase
WP4W18E11_19780	COG3659	wide pore channel activity
WP4W18E11_19790	COG3420	alginic acid biosynthetic process
WP4W18E11_19800	COG0710	3-dehydroquinate dehydratase activity
WP4W18E11_19810	COG3485	protocatechuate 3,4-dioxygenase
WP4W18E11_19820	COG3485	protocatechuate 3,4-dioxygenase
WP4W18E11_19830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP4W18E11_19840	COG2271	Major facilitator Superfamily
WP4W18E11_19850	COG0596	Alpha beta hydrolase
WP4W18E11_19860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP4W18E11_19870	COG0183	Belongs to the thiolase family
WP4W18E11_19880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WP4W18E11_19890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WP4W18E11_19910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP4W18E11_19920	COG2323	membrane
WP4W18E11_20010	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP4W18E11_20010	COG1902	pentaerythritol trinitrate reductase activity
WP4W18E11_20060	COG0542	response to heat
WP4W18E11_20070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP4W18E11_20130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP4W18E11_20140	COG0569	domain protein
WP4W18E11_20150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP4W18E11_20190	COG4774	siderophore transport
WP4W18E11_20200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP4W18E11_20220	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP4W18E11_20250	COG1294	oxidase, subunit
WP4W18E11_20260	COG4890	Cyd operon protein YbgT
WP4W18E11_20280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP4W18E11_20300	COG0552	protein localization to endoplasmic reticulum
WP4W18E11_20350	COG0516	GMP reductase activity
WP4W18E11_20350	COG0517	IMP dehydrogenase activity
WP4W18E11_20360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP4W18E11_20370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP4W18E11_20390	COG0583	DNA-binding transcription factor activity
WP4W18E11_20400	COG0024	Methionine aminopeptidase
WP4W18E11_20460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP4W18E11_20460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP4W18E11_20470	COG1105	Belongs to the carbohydrate kinase PfkB family
WP4W18E11_20480	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP4W18E11_20480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP4W18E11_20480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP4W18E11_20510	COG3300	MHYT domain
WP4W18E11_20510	COG5001	Diguanylate cyclase
WP4W18E11_20540	COG2135	peptidase activity
WP4W18E11_20550	COG3328	transposase activity
WP4W18E11_20570	COG0659	secondary active sulfate transmembrane transporter activity
WP4W18E11_20600	COG0833	amino acid
WP4W18E11_20610	COG3328	transposase activity
WP4W18E11_20620	COG3328	transposase activity
WP4W18E11_20650	COG1522	sequence-specific DNA binding
WP4W18E11_20700	COG1011	Hydrolase
WP4W18E11_20710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WP4W18E11_20730	COG2137	regulation of response to DNA damage stimulus
WP4W18E11_20750	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP4W18E11_20820	COG0575	Belongs to the CDS family
WP4W18E11_20830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP4W18E11_20870	COG3852	Histidine kinase
WP4W18E11_20880	COG2204	response regulator
WP4W18E11_20990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP4W18E11_21000	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP4W18E11_21040	COG0697	spore germination
WP4W18E11_21050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP4W18E11_21080	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP4W18E11_21080	COG0315	cyclic pyranopterin monophosphate synthase activity
WP4W18E11_21110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP4W18E11_21120	COG0243	molybdopterin cofactor binding
WP4W18E11_21140	COG0243	molybdopterin cofactor binding
WP4W18E11_21150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP4W18E11_21160	COG2146	nitrite reductase [NAD(P)H] activity
WP4W18E11_21160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP4W18E11_21180	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_21190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP4W18E11_21190	COG1116	anion transmembrane transporter activity
WP4W18E11_21210	COG1196	nuclear chromosome segregation
WP4W18E11_21260	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_21310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP4W18E11_21330	COG0511	ligase activity, forming carbon-carbon bonds
WP4W18E11_21360	COG2814	Major facilitator Superfamily
WP4W18E11_21410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP4W18E11_21480	COG3328	transposase activity
WP4W18E11_21740	COG1484	DNA-dependent DNA replication
WP4W18E11_21920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP4W18E11_22040	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_22060	COG0069	glutamate synthase activity
WP4W18E11_22100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WP4W18E11_22120	COG1454	alcohol dehydrogenase
WP4W18E11_22130	COG0824	Thioesterase
WP4W18E11_22140	COG3511	phospholipase C
WP4W18E11_22160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WP4W18E11_22220	COG2030	dehydratase
WP4W18E11_22240	COG0183	Belongs to the thiolase family
WP4W18E11_22260	COG0583	DNA-binding transcription factor activity
WP4W18E11_22270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP4W18E11_22290	COG1522	sequence-specific DNA binding
WP4W18E11_22300	COG3135	benzoate transporter
WP4W18E11_22320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WP4W18E11_22380	COG0589	response to stress
WP4W18E11_22390	COG0488	(ABC) transporter
WP4W18E11_22410	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_22440	COG0668	transmembrane transport
WP4W18E11_22510	COG0583	DNA-binding transcription factor activity
WP4W18E11_22520	COG2814	Major facilitator Superfamily
WP4W18E11_22530	COG2814	Major facilitator Superfamily
WP4W18E11_22540	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_22550	COG2814	Major facilitator Superfamily
WP4W18E11_22580	COG0583	DNA-binding transcription factor activity
WP4W18E11_22620	COG4569	acetaldehyde dehydrogenase (acetylating) activity
WP4W18E11_22630	COG3971	2-oxopent-4-enoate hydratase activity
WP4W18E11_22650	COG2271	Major facilitator Superfamily
WP4W18E11_22660	COG1234	tRNA 3'-trailer cleavage
WP4W18E11_22710	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_22770	COG2801	Transposase and inactivated derivatives
WP4W18E11_22790	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_22810	COG1605	Chorismate mutase
WP4W18E11_22860	COG0308	aminopeptidase N
WP4W18E11_22900	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
WP4W18E11_22910	COG2207	Transcriptional regulator
WP4W18E11_22910	COG3708	Transcriptional regulator
WP4W18E11_22930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP4W18E11_22940	COG1454	alcohol dehydrogenase
WP4W18E11_22980	COG0531	amino acid
WP4W18E11_22990	COG4303	Ethanolamine ammonia lyase large subunit
WP4W18E11_23000	COG4302	ethanolamine ammonia-lyase activity
WP4W18E11_23010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP4W18E11_23010	COG0519	Catalyzes the synthesis of GMP from XMP
WP4W18E11_23020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP4W18E11_23070	COG0697	spore germination
WP4W18E11_23080	COG1923	regulation of RNA biosynthetic process
WP4W18E11_23100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP4W18E11_23110	COG0802	atpase or kinase
WP4W18E11_23150	COG1187	pseudouridine synthase activity
WP4W18E11_23180	COG0583	DNA-binding transcription factor activity
WP4W18E11_23210	COG2814	Major facilitator Superfamily
WP4W18E11_23220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP4W18E11_23270	COG0729	surface antigen
WP4W18E11_23310	COG0174	glutamine synthetase
WP4W18E11_23320	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_23330	COG2205	protein histidine kinase activity
WP4W18E11_23360	COG1595	DNA-templated transcription, initiation
WP4W18E11_23400	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WP4W18E11_23410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WP4W18E11_23470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP4W18E11_23480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP4W18E11_23490	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_23550	COG0583	DNA-binding transcription factor activity
WP4W18E11_23580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP4W18E11_23600	COG3658	cytochrome
WP4W18E11_23610	COG1215	transferase activity, transferring glycosyl groups
WP4W18E11_23620	COG0726	polysaccharide deacetylase
WP4W18E11_23620	COG1649	PFAM Uncharacterised BCR, COG1649
WP4W18E11_23680	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP4W18E11_23690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP4W18E11_23710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP4W18E11_23760	COG0305	Participates in initiation and elongation during chromosome replication
WP4W18E11_23770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP4W18E11_23790	COG1305	Transglutaminase-like
WP4W18E11_23810	COG2308	Evidence 4 Homologs of previously reported genes of
WP4W18E11_23870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP4W18E11_23880	COG0138	bifunctional purine biosynthesis protein purh
WP4W18E11_23890	COG0151	Belongs to the GarS family
WP4W18E11_23900	COG1464	Belongs to the NlpA lipoprotein family
WP4W18E11_23910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP4W18E11_23920	COG2011	ABC-type metal ion transport system permease component
WP4W18E11_23930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP4W18E11_23950	COG1301	dicarboxylic acid transport
WP4W18E11_23960	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_24020	COG1794	racemase activity, acting on amino acids and derivatives
WP4W18E11_24040	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_24080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP4W18E11_24080	COG3008	intermembrane lipid transfer
WP4W18E11_24090	COG2995	paraquat-inducible protein a
WP4W18E11_24120	COG3328	transposase activity
WP4W18E11_24230	COG2186	Transcriptional regulator
WP4W18E11_24250	COG0786	glutamate:sodium symporter activity
WP4W18E11_24260	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP4W18E11_24310	COG3111	PFAM Bacterial OB fold (BOF) protein
WP4W18E11_24490	COG3210	domain, Protein
WP4W18E11_24500	COG2831	hemolysin activation secretion protein
WP4W18E11_24510	COG2815	serine threonine protein kinase
WP4W18E11_24510	COG0515	serine threonine protein kinase
WP4W18E11_24580	COG1610	YqeY-like protein
WP4W18E11_24590	COG4783	chaperone-mediated protein folding
WP4W18E11_24640	COG1286	toxin biosynthetic process
WP4W18E11_25310	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_25370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP4W18E11_25460	COG0778	Nitroreductase
WP4W18E11_25480	COG0513	Belongs to the DEAD box helicase family
WP4W18E11_25520	COG2363	Small membrane protein
WP4W18E11_25580	COG4650	regulator
WP4W18E11_25590	COG1234	tRNA 3'-trailer cleavage
WP4W18E11_25600	COG1690	Belongs to the RtcB family
WP4W18E11_25640	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP4W18E11_25660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP4W18E11_25680	COG2819	hydrolase of the alpha beta superfamily
WP4W18E11_25690	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_25700	COG1301	dicarboxylic acid transport
WP4W18E11_25720	COG3139	Protein of unknown function (DUF1315)
WP4W18E11_25730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP4W18E11_25740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP4W18E11_25760	COG0494	nUDIX hydrolase
WP4W18E11_25780	COG0642	Histidine kinase
WP4W18E11_25790	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_25830	COG1720	tRNA m6t6A37 methyltransferase activity
WP4W18E11_25860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP4W18E11_25880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP4W18E11_25900	COG4598	ABC transporter
WP4W18E11_25910	COG4160	amino acid transport
WP4W18E11_25920	COG4215	(ABC) transporter
WP4W18E11_25950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP4W18E11_26210	COG0582	viral genome integration into host DNA
WP4W18E11_26220	COG1131	(ABC) transporter
WP4W18E11_26230	COG0842	Transport permease protein
WP4W18E11_26260	COG0772	Belongs to the SEDS family
WP4W18E11_26270	COG2951	lytic endotransglycosylase activity
WP4W18E11_26330	COG3328	transposase activity
WP4W18E11_26350	COG2207	Transcriptional regulator
WP4W18E11_26380	COG0052	Belongs to the universal ribosomal protein uS2 family
WP4W18E11_26390	COG0024	Methionine aminopeptidase
WP4W18E11_26410	COG2223	nitrite transmembrane transporter activity
WP4W18E11_26440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP4W18E11_26450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP4W18E11_26460	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_26490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP4W18E11_26500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WP4W18E11_26510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP4W18E11_26550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP4W18E11_26560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP4W18E11_26570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP4W18E11_26610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP4W18E11_26630	COG0174	glutamine synthetase
WP4W18E11_26640	COG3104	oligopeptide transport
WP4W18E11_26660	COG0512	Glutamine amidotransferase of anthranilate synthase
WP4W18E11_26670	COG0308	aminopeptidase N
WP4W18E11_26710	COG2840	Smr protein MutS2
WP4W18E11_26730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP4W18E11_26790	COG3739	integral membrane protein
WP4W18E11_26820	COG1169	isochorismate synthase
WP4W18E11_26840	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
WP4W18E11_26850	COG5265	(ABC) transporter
WP4W18E11_26860	COG1132	(ABC) transporter
WP4W18E11_26890	COG1535	isochorismatase
WP4W18E11_26890	COG3433	isochorismatase activity
WP4W18E11_26900	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP4W18E11_26910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP4W18E11_26930	COG4774	siderophore transport
WP4W18E11_26940	COG4607	ABC-type enterochelin transport system periplasmic component
WP4W18E11_26950	COG4604	ABC transporter, ATP-binding protein
WP4W18E11_26960	COG4605	iron ion homeostasis
WP4W18E11_26970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP4W18E11_26990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP4W18E11_27030	COG1741	Belongs to the pirin family
WP4W18E11_27050	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_27070	COG0582	viral genome integration into host DNA
WP4W18E11_27080	COG2879	small protein
WP4W18E11_27090	COG1966	Carbon starvation protein
WP4W18E11_27130	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WP4W18E11_27170	COG2211	Major facilitator Superfamily
WP4W18E11_27180	COG1067	ATP-dependent peptidase activity
WP4W18E11_27190	COG0583	DNA-binding transcription factor activity
WP4W18E11_27240	COG1686	Belongs to the peptidase S11 family
WP4W18E11_27250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP4W18E11_27320	COG0616	signal peptide processing
WP4W18E11_27330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WP4W18E11_27350	COG0573	inorganic phosphate transmembrane transporter activity
WP4W18E11_27360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WP4W18E11_27370	COG1113	amino acid transport
WP4W18E11_27380	COG3961	Belongs to the TPP enzyme family
WP4W18E11_27390	COG1522	sequence-specific DNA binding
WP4W18E11_27400	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_27420	COG0076	glutamate decarboxylase activity
WP4W18E11_27430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WP4W18E11_27460	COG2801	Transposase and inactivated derivatives
WP4W18E11_27470	COG1309	transcriptional regulator
WP4W18E11_27500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP4W18E11_27570	COG0352	thiamine-phosphate diphosphorylase activity
WP4W18E11_27630	COG1203	CRISPR-associated helicase, Cas3
WP4W18E11_27690	COG0612	Peptidase, M16
WP4W18E11_27720	COG0583	DNA-binding transcription factor activity
WP4W18E11_27730	COG0477	Major facilitator Superfamily
WP4W18E11_27780	COG1187	pseudouridine synthase activity
WP4W18E11_27810	COG1686	Belongs to the peptidase S11 family
WP4W18E11_27820	COG1252	NADH dehydrogenase
WP4W18E11_27840	COG0415	Belongs to the DNA photolyase family
WP4W18E11_27870	COG1215	transferase activity, transferring glycosyl groups
WP4W18E11_27930	COG2070	2-Nitropropane dioxygenase
WP4W18E11_28040	COG0556	nucleotide-excision repair
WP4W18E11_28080	COG0436	Aminotransferase
WP4W18E11_28120	COG4221	oxidoreductase activity
WP4W18E11_28140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP4W18E11_28150	COG1381	Involved in DNA repair and RecF pathway recombination
WP4W18E11_28170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WP4W18E11_28200	COG0681	Belongs to the peptidase S26 family
WP4W18E11_28230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP4W18E11_28270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP4W18E11_28280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP4W18E11_28290	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP4W18E11_28310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP4W18E11_28320	COG4208	sulfate ABC transporter
WP4W18E11_28330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP4W18E11_28340	COG0583	DNA-binding transcription factor activity
WP4W18E11_28350	COG4625	pathogenesis
WP4W18E11_28380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP4W18E11_28410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP4W18E11_28430	COG1056	cytidyltransferase-related domain
WP4W18E11_28430	COG1051	belongs to the nudix hydrolase family
WP4W18E11_28440	COG1024	Enoyl-CoA hydratase
WP4W18E11_28470	COG2814	Major facilitator Superfamily
WP4W18E11_28480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP4W18E11_28480	COG0047	phosphoribosylformylglycinamidine synthase activity
WP4W18E11_28520	COG1473	amidohydrolase
WP4W18E11_28530	COG0824	Thioesterase
WP4W18E11_28570	COG0823	Involved in the tonB-independent uptake of proteins
WP4W18E11_28610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP4W18E11_28680	COG0628	permease
WP4W18E11_28700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP4W18E11_28710	COG0596	Alpha beta hydrolase
WP4W18E11_28720	COG0616	signal peptide processing
WP4W18E11_28720	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP4W18E11_28740	COG0658	competence protein
WP4W18E11_28740	COG2333	competence protein COMEC
WP4W18E11_28750	COG1136	(ABC) transporter
WP4W18E11_28760	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP4W18E11_28830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP4W18E11_28870	COG0463	Glycosyl transferase, family 2
WP4W18E11_28930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WP4W18E11_28940	COG1280	lysine exporter protein (LysE YggA)
WP4W18E11_28960	COG0019	diaminopimelate decarboxylase activity
WP4W18E11_28980	COG1113	amino acid transport
WP4W18E11_29030	COG3339	Conserved Protein
WP4W18E11_29040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP4W18E11_29050	COG0243	molybdopterin cofactor binding
WP4W18E11_29060	COG1929	Belongs to the glycerate kinase type-1 family
WP4W18E11_29090	COG0778	Nitroreductase
WP4W18E11_29140	COG3328	transposase activity
WP4W18E11_29150	COG2801	Transposase and inactivated derivatives
WP4W18E11_29190	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_29200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP4W18E11_29210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP4W18E11_29230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP4W18E11_29270	COG0741	lytic transglycosylase activity
WP4W18E11_29310	COG0584	glycerophosphoryl diester phosphodiesterase
WP4W18E11_29320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP4W18E11_29360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WP4W18E11_29370	COG1597	lipid kinase activity
WP4W18E11_29410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP4W18E11_29420	COG0477	Major facilitator Superfamily
WP4W18E11_29490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP4W18E11_29500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP4W18E11_29550	COG0505	Belongs to the CarA family
WP4W18E11_29590	COG0589	response to stress
WP4W18E11_29620	COG2843	Capsule synthesis protein
WP4W18E11_29640	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_29750	COG2321	neutral zinc metallopeptidase
WP4W18E11_29760	COG2354	Protein conserved in bacteria
WP4W18E11_29800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP4W18E11_29830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP4W18E11_29840	COG1053	succinate dehydrogenase
WP4W18E11_29850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP4W18E11_29860	COG2009	succinate dehydrogenase
WP4W18E11_29930	COG2921	Belongs to the UPF0250 family
WP4W18E11_29940	COG0321	lipoyl(octanoyl) transferase activity
WP4W18E11_29970	COG0531	amino acid
WP4W18E11_29990	COG1733	regulation of RNA biosynthetic process
WP4W18E11_30000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP4W18E11_30010	COG1648	precorrin-2 dehydrogenase activity
WP4W18E11_30010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP4W18E11_30040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP4W18E11_30090	COG0671	phosphoesterase, PA-phosphatase related
WP4W18E11_30100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP4W18E11_30120	COG1538	Outer membrane efflux protein
WP4W18E11_30130	COG0393	Putative heavy-metal-binding
WP4W18E11_30140	COG0393	Putative heavy-metal-binding
WP4W18E11_30160	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_30180	COG0525	valine-tRNA ligase activity
WP4W18E11_30220	COG0583	DNA-binding transcription factor activity
WP4W18E11_30230	COG0004	ammonium transporteR
WP4W18E11_30250	COG0642	Histidine kinase
WP4W18E11_30260	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_30270	COG2194	sulfuric ester hydrolase activity
WP4W18E11_30310	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP4W18E11_30340	COG2315	Protein conserved in bacteria
WP4W18E11_30350	COG0142	geranyltranstransferase activity
WP4W18E11_30360	COG2828	Protein conserved in bacteria
WP4W18E11_30370	COG1113	amino acid transport
WP4W18E11_30380	COG0582	viral genome integration into host DNA
WP4W18E11_30410	COG0582	viral genome integration into host DNA
WP4W18E11_30450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP4W18E11_30460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP4W18E11_30470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP4W18E11_30480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP4W18E11_30490	COG3706	GGDEF domain
WP4W18E11_30540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP4W18E11_30580	COG2207	Transcriptional regulator
WP4W18E11_30630	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP4W18E11_30650	COG0560	Phosphoserine phosphatase
WP4W18E11_30670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP4W18E11_30690	COG1530	ribonuclease E activity
WP4W18E11_30700	COG0424	maF-like protein
WP4W18E11_30710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP4W18E11_30720	COG1792	Involved in formation and maintenance of cell shape
WP4W18E11_30730	COG1077	Cell shape determining protein MreB Mrl
WP4W18E11_30740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WP4W18E11_30760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WP4W18E11_30800	COG3590	peptidase
WP4W18E11_30810	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
WP4W18E11_30820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP4W18E11_30830	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP4W18E11_30840	COG1115	amino acid carrier protein
WP4W18E11_30870	COG2814	Major facilitator Superfamily
WP4W18E11_30880	COG1289	transmembrane transporter activity
WP4W18E11_30900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP4W18E11_30920	COG1376	ErfK ybiS ycfS ynhG family protein
WP4W18E11_30930	COG2832	Protein of unknown function (DUF454)
WP4W18E11_30950	COG5510	response to toxic substance
WP4W18E11_30990	COG0840	transmembrane signaling receptor activity
WP4W18E11_31070	COG3422	double-strand break repair
WP4W18E11_31080	COG2824	Alkylphosphonate utilization operon protein PhnA
WP4W18E11_31110	COG0354	folic acid binding
WP4W18E11_31120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP4W18E11_31150	COG1902	pentaerythritol trinitrate reductase activity
WP4W18E11_31160	COG4772	TonB-dependent receptor
WP4W18E11_31170	COG2094	Belongs to the DNA glycosylase MPG family
WP4W18E11_31230	COG2233	PERMEase
WP4W18E11_31250	COG0833	amino acid
WP4W18E11_31260	COG1690	Belongs to the RtcB family
WP4W18E11_31280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WP4W18E11_31280	COG2885	chlorophyll binding
WP4W18E11_31300	COG0183	Belongs to the thiolase family
WP4W18E11_31320	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_31350	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP4W18E11_31390	COG2207	Transcriptional regulator
WP4W18E11_31400	COG0183	Belongs to the thiolase family
WP4W18E11_31460	COG1272	protein, Hemolysin III
WP4W18E11_31470	COG0477	Major facilitator Superfamily
WP4W18E11_31500	COG0450	alkyl hydroperoxide reductase
WP4W18E11_31540	COG0285	dihydrofolate synthase activity
WP4W18E11_31640	COG2096	Adenosyltransferase
WP4W18E11_31680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP4W18E11_31690	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_31700	COG2205	protein histidine kinase activity
WP4W18E11_31720	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_31730	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_31830	COG1215	transferase activity, transferring glycosyl groups
WP4W18E11_31860	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP4W18E11_31900	COG0726	polysaccharide deacetylase
WP4W18E11_31930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP4W18E11_31940	COG2205	protein histidine kinase activity
WP4W18E11_31990	COG1862	Preprotein translocase
WP4W18E11_32010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP4W18E11_32020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP4W18E11_32040	COG3781	membrane
WP4W18E11_32050	COG0613	PHP domain protein
WP4W18E11_32070	COG2350	Protein conserved in bacteria
WP4W18E11_32130	COG1607	acyl-coa hydrolase
WP4W18E11_32200	COG2199	diguanylate cyclase activity
WP4W18E11_32220	COG1408	metallophosphoesterase
WP4W18E11_32230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP4W18E11_32250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP4W18E11_32290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP4W18E11_32300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP4W18E11_32330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP4W18E11_32350	COG2969	positive regulation of protein catabolic process
WP4W18E11_32390	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_32400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP4W18E11_32430	COG1309	transcriptional regulator
WP4W18E11_32440	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_32480	COG1183	phosphatidylcholine synthase activity
WP4W18E11_32490	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP4W18E11_32550	COG0739	heme binding
WP4W18E11_32550	COG1196	nuclear chromosome segregation
WP4W18E11_32550	COG0741	lytic transglycosylase activity
WP4W18E11_32570	COG1702	phosphate starvation-inducible protein PhoH
WP4W18E11_32640	COG1295	ribonuclease BN
WP4W18E11_32650	COG0697	spore germination
WP4W18E11_32660	COG2169	Transcriptional regulator
WP4W18E11_32670	COG0179	Fumarylacetoacetate (FAA) hydrolase
WP4W18E11_32720	COG0557	exoribonuclease II activity
WP4W18E11_32730	COG0339	signal peptide processing
WP4W18E11_32740	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP4W18E11_32810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP4W18E11_32820	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_33130	COG0626	cystathionine gamma-synthase activity
WP4W18E11_33140	COG0433	COG0433 Predicted ATPase
WP4W18E11_33150	COG1017	nitric oxide dioxygenase activity
WP4W18E11_33150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP4W18E11_33160	COG1959	2 iron, 2 sulfur cluster binding
WP4W18E11_33190	COG1301	dicarboxylic acid transport
WP4W18E11_33200	COG1946	Acyl-CoA thioesterase
WP4W18E11_33240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP4W18E11_33250	COG1040	competence protein
WP4W18E11_33260	COG0494	nUDIX hydrolase
WP4W18E11_33280	COG0598	Magnesium transport protein CorA
WP4W18E11_33300	COG2854	intermembrane phospholipid transfer
WP4W18E11_33320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP4W18E11_33330	COG1127	ABC transporter
WP4W18E11_33340	COG0513	Belongs to the DEAD box helicase family
WP4W18E11_33380	COG0408	coproporphyrinogen oxidase activity
WP4W18E11_33410	COG1960	acyl-CoA dehydrogenase activity
WP4W18E11_33430	COG1983	PspC domain protein
WP4W18E11_33440	COG0517	IMP dehydrogenase activity
WP4W18E11_33510	COG1106	Psort location Cytoplasmic, score
WP4W18E11_33550	COG0583	DNA-binding transcription factor activity
WP4W18E11_33630	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_33650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP4W18E11_33660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP4W18E11_33670	COG0833	amino acid
WP4W18E11_33750	COG0628	permease
WP4W18E11_33770	COG1289	transmembrane transporter activity
WP4W18E11_33800	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP4W18E11_33810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
WP4W18E11_33830	COG0277	FAD linked oxidase domain protein
WP4W18E11_33840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP4W18E11_33870	COG5006	permease, DMT superfamily
WP4W18E11_33900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP4W18E11_33910	COG5380	lipid catabolic process
WP4W18E11_33950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP4W18E11_34050	COG0194	GDP metabolic process
WP4W18E11_34070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP4W18E11_34110	COG3307	-O-antigen
WP4W18E11_34150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP4W18E11_34160	COG1704	LemA family
WP4W18E11_34180	COG0493	'glutamate synthase
WP4W18E11_34190	COG0067	glutamate synthase
WP4W18E11_34190	COG0069	glutamate synthase activity
WP4W18E11_34190	COG0070	glutamate synthase
WP4W18E11_34290	COG2226	methyltransferase
WP4W18E11_34320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP4W18E11_34330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP4W18E11_34400	COG0833	amino acid
WP4W18E11_34540	COG0488	(ABC) transporter
WP4W18E11_34550	COG2873	o-acetylhomoserine
WP4W18E11_34560	COG4221	oxidoreductase activity
WP4W18E11_34570	COG0659	secondary active sulfate transmembrane transporter activity
WP4W18E11_34590	COG0745	RESPONSE REGULATOR receiver
WP4W18E11_34610	COG0427	acetyl-CoA hydrolase
WP4W18E11_34650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP4W18E11_34710	COG2329	Antibiotic biosynthesis monooxygenase
WP4W18E11_34740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP4W18E11_34840	COG2207	Transcriptional regulator
WP4W18E11_34850	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP4W18E11_34870	COG0667	Aldo Keto reductase
WP4W18E11_34910	COG0583	DNA-binding transcription factor activity
WP4W18E11_34920	COG2814	Major facilitator Superfamily
WP4W18E11_34980	COG1335	isochorismatase
WP4W18E11_35000	COG1012	belongs to the aldehyde dehydrogenase family
WP4W18E11_35010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WP4W18E11_35030	COG1113	amino acid transport
WP4W18E11_35050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WP4W18E11_35080	COG2814	Major facilitator Superfamily
WP4W18E11_35100	COG0351	phosphomethylpyrimidine kinase
WP4W18E11_35100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WP4W18E11_35100	COG0352	thiamine-phosphate diphosphorylase activity
WP4W18E11_35140	COG1309	transcriptional regulator
WP4W18E11_35150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP4W18E11_35160	COG3706	GGDEF domain
WP4W18E11_35180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP4W18E11_35200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP4W18E11_35210	COG3162	membrane
WP4W18E11_35220	COG2198	Histidine kinase
WP4W18E11_35220	COG2205	protein histidine kinase activity
WP4W18E11_35220	COG0784	Response regulator, receiver
WP4W18E11_35270	COG1522	sequence-specific DNA binding
WP4W18E11_35280	COG1335	isochorismatase
WP4W18E11_35290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP4W18E11_35310	COG0668	transmembrane transport
WP4W18E11_35320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP4W18E11_35330	COG1519	Transferase
WP4W18E11_35340	COG1902	pentaerythritol trinitrate reductase activity
WP4W18E11_35390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WP4W18E11_35440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WP4W18E11_35440	COG0426	domain, Protein
WP4W18E11_35450	COG4774	siderophore transport
WP4W18E11_35460	COG2119	membrane
WP4W18E11_35480	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP4W18E11_35500	COG4942	peptidase
WP4W18E11_35530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP4W18E11_35550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP4W18E11_35590	COG0189	ligase activity
WP4W18E11_35640	COG0708	Exodeoxyribonuclease III
WP4W18E11_35650	COG1393	Belongs to the ArsC family
WP4W18E11_35680	COG3706	GGDEF domain
WP4W18E11_35750	COG2351	hydroxyisourate hydrolase activity
WP4W18E11_35760	COG2233	PERMEase
WP4W18E11_35780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP4W18E11_35800	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
WP4W18E11_35810	COG1028	Short-chain dehydrogenase reductase Sdr
WP4W18E11_35830	COG3150	esterase
WP4W18E11_35950	COG2918	glutathione biosynthetic process
WP4W18E11_35980	COG2733	membrane
WP4W18E11_35990	COG0436	Aminotransferase
WP4W18E11_36000	COG0534	Mate efflux family protein
WP4W18E11_36170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP4W18E11_36180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP4W18E11_36200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP4W18E11_36290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WP4W18E11_36300	COG0546	phosphoglycolate phosphatase activity
WP4W18E11_36320	COG0010	Belongs to the arginase family
WP4W18E11_36380	COG2188	Transcriptional regulator
WP4W18E11_36390	COG2826	transposase and inactivated derivatives, IS30 family
WP4W18E11_36410	COG0523	cobalamin synthesis protein
WP4W18E11_36430	COG1113	amino acid transport
WP4W18E11_36450	COG0625	glutathione transferase activity
WP4W18E11_36490	COG1683	Conserved Protein
WP4W18E11_36500	COG0534	Mate efflux family protein
WP4W18E11_36510	COG0385	Bile acid
WP4W18E11_36520	COG1335	isochorismatase
WP4W18E11_36530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP4W18E11_36570	COG2116	formate transmembrane transporter activity
WP4W18E11_36580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP4W18E11_36590	COG2133	pyrroloquinoline quinone binding
WP4W18E11_36600	COG2983	Belongs to the UPF0260 family
WP4W18E11_36640	COG1194	a g-specific adenine glycosylase
WP4W18E11_36670	COG2818	Glycosylase
WP4W18E11_36680	COG1064	alcohol dehydrogenase
WP4W18E11_36690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP4W18E11_36710	COG0583	DNA-binding transcription factor activity
WP4W18E11_36720	COG0656	L-ascorbic acid biosynthetic process
WP4W18E11_36730	COG2814	Major facilitator Superfamily
WP4W18E11_36800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP4W18E11_36830	COG2233	PERMEase
WP4W18E11_36840	COG0583	DNA-binding transcription factor activity
WP4W18E11_36910	COG0733	neurotransmitter:sodium symporter activity
WP4W18E11_36940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP4W18E11_36990	COG0583	DNA-binding transcription factor activity
WP4W18E11_37020	COG2801	Transposase and inactivated derivatives
WP4W18E11_37070	COG2951	lytic endotransglycosylase activity
WP4W18E11_37090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP4W18E11_37120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP4W18E11_37140	COG0671	phosphoesterase, PA-phosphatase related
WP4W18E11_37150	COG0861	Integral membrane protein TerC family
WP4W18E11_37170	COG0754	glutathionylspermidine amidase activity
WP4W18E11_37190	COG0402	S-adenosylhomocysteine deaminase activity
WP4W18E11_37230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP4W18E11_37240	COG1230	cation diffusion facilitator family transporter
WP4W18E11_37270	COG0706	membrane insertase activity