locus-tag class description AYR67_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AYR67_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AYR67_00030 ENOG4105DQR SNARE associated Golgi AYR67_00035 ENOG4105C5H ABC transporter AYR67_00040 ENOG4108821 RND type efflux pump AYR67_00045 ENOG4108821 RND type efflux pump AYR67_00050 ENOG4108821 RND type efflux pump AYR67_00060 ENOG4105D74 hydrolase AYR67_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AYR67_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AYR67_00110 ENOG4105C8J )-transporter AYR67_00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AYR67_00145 ENOG4108W5M transcriptional regulator AYR67_00150 ENOG4105C2W permease AYR67_00160 ENOG4108IG5 Transcriptional regulator AYR67_00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit AYR67_00200 ENOG4105F27 Major Facilitator AYR67_00205 ENOG4105CV8 reductase AYR67_00210 ENOG4105HEI LysR family (Transcriptional regulator AYR67_00225 ENOG4105DQ4 alcohol dehydrogenase AYR67_00230 ENOG4108R3E Dna-3-methyladenine glycosylase i AYR67_00245 ENOG4105CEN a g-specific adenine glycosylase AYR67_00265 ENOG4108ZZ3 UPF0260 protein AYR67_00275 ENOG4105D1H recombination factor protein RarA AYR67_00280 ENOG4105S64 Formate nitrite transporter AYR67_00300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AYR67_00305 ENOG4108RWI nicotinamidase AYR67_00310 ENOG4105C09 Bile acid AYR67_00315 ENOG4107QI1 Mate efflux family protein AYR67_00320 ENOG4105EWC Purine nucleoside phosphorylase AYR67_00340 ENOG4108RXX maleylacetoacetate isomerase AYR67_00350 ENOG4105C85 amino acid AYR67_00360 ENOG4105CKI cobalamin synthesis protein AYR67_00370 ENOG4105CZE histidine utilization repressor AYR67_00375 ENOG41090B9 response to stress AYR67_00390 ENOG4105C85 amino acid AYR67_00400 ENOG41088SP formiminoglutamate hydrolase AYR67_00410 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AYR67_00415 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AYR67_00420 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AYR67_00430 ENOG4108ZAI phosphatidylglycerophosphatase a AYR67_00435 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AYR67_00450 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AYR67_00485 ENOG4105KHC sulfurtransferase AYR67_00500 ENOG4105BZU Histidine kinase AYR67_00505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AYR67_00520 ENOG4107QJQ Mate efflux family protein AYR67_00525 ENOG4105CHM Aminotransferase AYR67_00530 ENOG4106BRA Membrane AYR67_00545 ENOG4105D9M gamma-glutamylcysteine synthetase AYR67_00570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AYR67_00575 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AYR67_00580 ENOG4108Z2U ureidoglycolate hydrolase AYR67_00590 ENOG41061H0 Monooxygenase AYR67_00605 ENOG41084YZ Hydrolase AYR67_00635 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AYR67_00640 ENOG4105BZU Histidine kinase AYR67_00655 ENOG4105KUZ arsenate reductase AYR67_00660 ENOG4105CGK Exodeoxyribonuclease III AYR67_00680 ENOG4105D7Z glutathione synthase AYR67_00700 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AYR67_00705 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AYR67_00710 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AYR67_00725 ENOG41063SB peptidase AYR67_00730 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AYR67_00735 ENOG4107QSN dihydrolipoamide acetyltransferase AYR67_00750 ENOG4105E0K tonB-dependent siderophore receptor AYR67_00765 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AYR67_00780 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AYR67_00790 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AYR67_00800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AYR67_00805 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AYR67_00815 ENOG4105D64 Mechanosensitive ion channel AYR67_00825 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AYR67_00830 ENOG4108W2Y isochorismatase AYR67_00840 ENOG4105FBW Monooxygenase AYR67_00845 ENOG4108UZX fmn reductase AYR67_00860 ENOG4105BZU Histidine kinase AYR67_00865 ENOG41062QD Membrane AYR67_00870 ENOG4107QN1 sodium solute AYR67_00880 ENOG4105C94 Transporter AYR67_00890 ENOG4105BZU Histidine kinase AYR67_00895 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AYR67_00900 ENOG4108WUH Transcriptional regulator, TetR family AYR67_00915 ENOG4105RA2 Membrane AYR67_00920 ENOG4105DWF phosphomethylpyrimidine kinase AYR67_00930 ENOG4107RDB Major Facilitator AYR67_00935 ENOG4108UUM single-stranded DNA-binding protein AYR67_00945 ENOG4108UMN azlc family AYR67_00955 ENOG4105C85 amino acid AYR67_00965 ENOG4108JPW Aminotransferase AYR67_00970 ENOG4105C26 Dehydrogenase AYR67_00980 ENOG4105CHJ isochorismatase hydrolase AYR67_00985 ENOG4105EUB pirin domain protein AYR67_01010 ENOG4105D94 Major Facilitator Superfamily AYR67_01015 ENOG4106NZI LysR family Transcriptional regulator AYR67_01035 ENOG4105CPC Aldo Keto reductase AYR67_01040 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) AYR67_01065 ENOG4105KVH Transcriptional regulator AYR67_01070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AYR67_01135 ENOG4105CUV Homoserine Kinase AYR67_01150 ENOG41061CK Antibiotic biosynthesis monooxygenase AYR67_01180 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AYR67_01210 ENOG4105CYC Transferase AYR67_01215 ENOG4105E0F Histidine kinase AYR67_01220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AYR67_01230 ENOG4105CHH sulfate transporter AYR67_01235 ENOG4105PDP Short chain dehydrogenase AYR67_01245 ENOG4105C5H ABC transporter AYR67_01325 ENOG4108IQI permease AYR67_01350 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AYR67_01365 ENOG4105CJN penicillin-binding protein AYR67_01370 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AYR67_01375 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AYR67_01390 ENOG4105DHI Methyltransferase AYR67_01395 ENOG4108JQC penicillin-binding protein 1A AYR67_01420 ENOG4105E4G Type IV pilus AYR67_01440 ENOG4105CBC glutamate synthase AYR67_01445 ENOG4105BZ8 glutamate synthase AYR67_01455 ENOG4108V0P LemA family AYR67_01460 ENOG4105HA9 of methanol dehydrogenase type AYR67_01480 ENOG4108YSG O-Antigen polymerase AYR67_01485 ENOG4108UQY Iron-storage protein AYR67_01495 ENOG4105KME endoribonuclease L-psp AYR67_01500 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AYR67_01510 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AYR67_01560 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AYR67_01575 ENOG4107IFA Lipase (EC 3.1.1.3) AYR67_01580 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) AYR67_01585 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AYR67_01610 ENOG4108JQ1 Dehydrogenase AYR67_01615 ENOG4105CQB FAD linked oxidase domain protein AYR67_01625 ENOG4105VRH Antibiotic biosynthesis monooxygenase AYR67_01630 ENOG4105NF4 modulator of drug activity AYR67_01640 ENOG4107QF7 multi-drug AYR67_01645 ENOG4105EM2 membrane AYR67_01650 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AYR67_01655 ENOG4105IPI Membrane AYR67_01660 ENOG4107SKI cobyrinic Acid a,c-diamide synthase AYR67_01690 ENOG4108IQI permease AYR67_01695 ENOG4105D82 Glutamate dehydrogenase AYR67_01700 ENOG4105C8Y Acetylornithine aminotransferase AYR67_01710 ENOG4105C26 Dehydrogenase AYR67_01735 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AYR67_01795 ENOG4105W87 Cbs domain AYR67_01800 ENOG41067S9 phage shock protein C, PspC AYR67_01810 ENOG4105CSU acyl-Coa dehydrogenase AYR67_01825 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AYR67_01840 ENOG4105ECY inositol monophosphatase AYR67_01845 ENOG4105C1J atp-dependent rna helicase AYR67_01855 ENOG4105DHJ ABC, transporter AYR67_01860 ENOG4105CY3 ABC transporter, permease AYR67_01870 ENOG4105E3I toluene tolerance AYR67_01880 ENOG4105D7N magnesium and cobalt transport protein CorA AYR67_01885 ENOG4108URH decarboxylase AYR67_01895 ENOG4105MJ2 Competence protein AYR67_01900 ENOG4105CB5 ATP-dependent DNA helicase recG AYR67_01920 ENOG4105C29 acyl-CoA thioesterase AYR67_01925 ENOG4105CK2 sodium dicarboxylate symporter AYR67_01940 ENOG4105KPV Transcriptional regulator AYR67_01950 ENOG4105D7A ATP-binding protein AYR67_01955 ENOG4105C28 cystathionine AYR67_01960 ENOG41089BK Glutamine amido-transferase AYR67_02070 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AYR67_02075 ENOG41067V7 50S ribosomal protein L36 AYR67_02085 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AYR67_02110 ENOG4105C1G acyl-Coa dehydrogenase AYR67_02145 ENOG4105VKU nucleicacid-binding protein AYR67_02150 ENOG4105DGW oligopeptidase A AYR67_02155 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AYR67_02200 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AYR67_02205 ENOG4108K2B transcriptional regulator AYR67_02215 ENOG4107S2Z UPF0761 membrane protein AYR67_02220 ENOG4105CS1 NAD(P)H quinone oxidoreductase AYR67_02250 ENOG4105C9A Phoh family AYR67_02260 ENOG4105E4C Lytic transglycosylase catalytic AYR67_02290 ENOG4105D6S protein involved in catabolism of external DNA AYR67_02295 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AYR67_02340 ENOG4105C1G acyl-Coa dehydrogenase AYR67_02345 ENOG4108RZE Tetr family transcriptional regulator AYR67_02360 ENOG4107QX3 carboxylase AYR67_02365 ENOG4105C1G acyl-Coa dehydrogenase AYR67_02385 ENOG4105KB2 stringent starvation protein b AYR67_02390 ENOG4107MKT Stringent starvation protein a AYR67_02395 ENOG4108UJD 30S ribosomal protein S9 AYR67_02405 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AYR67_02410 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AYR67_02415 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AYR67_02435 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AYR67_02445 ENOG4107RZC phospholipase d AYR67_02455 ENOG4105UYK outer membrane protein a AYR67_02460 ENOG4108KHX Diguanylate cyclase AYR67_02495 ENOG4107QN2 dihydrolipoyl dehydrogenase AYR67_02505 ENOG4107QPB Beta-lactamase domain protein AYR67_02510 ENOG4107U2T alpha beta AYR67_02520 ENOG4105NAU thioesterase Superfamily protein AYR67_02550 ENOG4105K9H YciI-like protein AYR67_02560 ENOG4105DB7 PHP domain protein AYR67_02565 ENOG4105FFC UPF0187 protein AYR67_02575 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AYR67_02580 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AYR67_02585 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AYR67_02590 ENOG4105VIE preprotein translocase, subunit YajC AYR67_02620 ENOG4105BZU Histidine kinase AYR67_02625 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AYR67_02630 ENOG4105CM2 brancheD-chain amino acid aminotransferase AYR67_02645 ENOG4107BJW polysaccharide deacetylase AYR67_02655 ENOG4108PQP glycosyl transferase group 1 AYR67_02695 ENOG4105UGU tonB-dependent Receptor AYR67_02715 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AYR67_02720 ENOG4108K3A Glutathione S-transferase AYR67_02725 ENOG4108R4R Iron-regulated virulence regulatory protein AYR67_02730 ENOG4105CSU acyl-Coa dehydrogenase AYR67_02735 ENOG4105CSU acyl-Coa dehydrogenase AYR67_02745 ENOG4105EB3 Histidine kinase AYR67_02750 ENOG4105E3W Two component transcriptional regulator (Winged helix family AYR67_02755 ENOG4105CNG UPF0061 protein AYR67_02775 ENOG4108WBT adenosyltransferase AYR67_02790 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AYR67_02825 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AYR67_02845 ENOG4105D3R alkyl hydroperoxide reductase AYR67_02860 ENOG4105CSH Transporter AYR67_02865 ENOG4108UT2 hemolysin iii AYR67_02895 ENOG4105CHU acetyl-coa acetyltransferase AYR67_02900 ENOG4108R6W Transcriptional regulator, ARAC family AYR67_02910 ENOG4105TW1 Carbohydrate-selective porin OprB AYR67_02915 ENOG4105DZG Dehydrogenase AYR67_02920 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AYR67_02930 ENOG410814C multidrug resistance protein AYR67_02940 ENOG4105CHU acetyl-coa acetyltransferase AYR67_02950 ENOG4108WHA ompa motb domain protein AYR67_02960 ENOG4105E0Y RtcB Protein AYR67_02965 ENOG4108IQI permease AYR67_02975 ENOG4105C2W permease AYR67_02995 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AYR67_03005 ENOG4108VX5 3-methyladenine DNA glycosylase AYR67_03030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AYR67_03035 ENOG4108N2Y auxin Efflux AYR67_03045 ENOG4105T95 Thiol disulfide interChange protein AYR67_03050 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AYR67_03060 ENOG4105K78 MarR family Transcriptional regulator AYR67_03065 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AYR67_03070 ENOG4105KWI UPF0339 protein AYR67_03095 ENOG4108UNF response regulator AYR67_03100 ENOG4105M3Z response regulator AYR67_03105 ENOG4108ZGA chew protein AYR67_03110 ENOG4105C8Q Methyl-accepting chemotaxis AYR67_03115 ENOG4105CBS Chea signal transduction histidine kinase AYR67_03130 ENOG4106HKS Entericidin EcnA/B family AYR67_03140 ENOG4105WD1 Membrane AYR67_03145 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AYR67_03185 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AYR67_03195 ENOG4105EM2 membrane AYR67_03200 ENOG4105C2C drug resistance transporter, Bcr CflA AYR67_03215 ENOG4105BZG amino acid carrier protein AYR67_03220 ENOG4105D78 K07001 NTE family protein AYR67_03225 ENOG4105C7B Threonine dehydratase AYR67_03270 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AYR67_03280 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AYR67_03285 ENOG4105DFF Rod shape-determining protein mreb AYR67_03290 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AYR67_03295 ENOG4105VQ7 Rod shape-determining protein MreD AYR67_03300 ENOG4108Z03 MAF-like protein AYR67_03305 ENOG4105C03 ribonuclease AYR67_03315 ENOG4105D8T Acyltransferase AYR67_03325 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein AYR67_03335 ENOG4108X0B nad(p)h dehydrogenase (quinone) AYR67_03360 ENOG4105CF7 AraC family transcriptional regulator AYR67_03380 ENOG4105C85 amino acid AYR67_03385 ENOG4105C7F AcnD-accessory protein PrpF AYR67_03390 ENOG4105CTB Polyprenyl synthetase AYR67_03395 ENOG4105MSB protein, conserved in bacteria AYR67_03410 ENOG4105D78 K07001 NTE family protein AYR67_03430 ENOG4105DIJ Phosphoethanolamine transferase AYR67_03435 ENOG4105XJC Two component transcriptional regulator (Winged helix family AYR67_03440 ENOG4105DHQ Histidine kinase AYR67_03455 ENOG4108M0I Transcriptional regulator AYR67_03475 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AYR67_03495 ENOG4105K8R UPF0145 protein AYR67_03500 ENOG4105K8R UPF0145 protein AYR67_03505 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AYR67_03510 ENOG4105BZS acriflavin resistance protein AYR67_03515 ENOG4105C1P efflux transporter, rnd family, mfp subunit AYR67_03520 ENOG410841Q phosphoesterase PA-phosphatase related protein AYR67_03550 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AYR67_03565 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AYR67_03570 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AYR67_03575 ENOG4105KVH Transcriptional regulator AYR67_03585 ENOG4105CUB amino acid AYR67_03600 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AYR67_03605 ENOG41084BA UPF0250 protein AYR67_03610 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AYR67_03645 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AYR67_03650 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AYR67_03660 ENOG4105E33 succinate dehydrogenase AYR67_03665 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AYR67_03670 ENOG4105C7S Dehydrogenase AYR67_03675 ENOG4107QN2 dihydrolipoyl dehydrogenase AYR67_03685 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AYR67_03695 ENOG4105CKW Inner membrane protein yedI AYR67_03700 ENOG4105CGZ zinc metallopeptidase AYR67_03705 ENOG4105EEQ Na H antiporter AYR67_03720 ENOG4105PNM synthesis protein AYR67_03735 ENOG41080TK Universal stress protein AYR67_03750 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AYR67_03755 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AYR67_03770 ENOG4105HBR Rna-binding protein AYR67_03780 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AYR67_03785 ENOG4105EEI dihydropteroate synthase AYR67_03835 ENOG4105CSH Transporter AYR67_03840 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AYR67_03845 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AYR67_03860 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AYR67_03880 ENOG41080IJ Diacylglycerol kinase AYR67_03890 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AYR67_03895 ENOG4105BZS acriflavin resistance protein AYR67_03910 ENOG4105E4C Lytic transglycosylase catalytic AYR67_03930 ENOG4108RRZ Transcription elongation factor GreB AYR67_03945 ENOG4105CEY Amp-dependent synthetase and ligase AYR67_03985 ENOG4105BZW Glycerate kinase AYR67_03990 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AYR67_03995 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AYR67_04010 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AYR67_04020 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AYR67_04025 ENOG4105C85 amino acid AYR67_04035 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AYR67_04045 ENOG4105N14 lysine exporter protein LysE YggA AYR67_04050 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AYR67_04055 ENOG4105BZJ Electron transfer flavoprotein AYR67_04060 ENOG4105C10 Electron transfer flavoprotein AYR67_04065 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AYR67_04100 ENOG4107KET secretion protein, HlyD family AYR67_04130 ENOG4105D60 lipoprotein releasing system transmembrane protein AYR67_04135 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AYR67_04140 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AYR67_04150 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AYR67_04155 ENOG4107R6F Alpha Beta Hydrolase Fold protein AYR67_04160 ENOG4108V3E phosphoribosylglycinamide formyltransferase AYR67_04170 ENOG4105C02 permease AYR67_04220 ENOG4105KCK Peptidoglycan-associated lipoprotein AYR67_04225 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AYR67_04235 ENOG4105M8F Biopolymer transport protein exbD tolR AYR67_04240 ENOG4105E02 MotA TolQ exbB proton channel AYR67_04245 ENOG4107YD3 Thioesterase AYR67_04250 ENOG4105CH2 amidohydrolase AYR67_04270 ENOG4108ETH Formylglycinamide ribotide synthetase AYR67_04275 ENOG4105C2C drug resistance transporter, Bcr CflA AYR67_04285 ENOG4105EGD dinuclear metal center protein, YbgI family AYR67_04290 ENOG4108UKI Enoyl-CoA hydratase AYR67_04305 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AYR67_04320 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AYR67_04325 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AYR67_04340 ENOG4107R11 Transcriptional regulator AYR67_04345 ENOG4108IJ6 ABC transporter AYR67_04355 ENOG4108I5D sulfate abc transporter AYR67_04365 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AYR67_04370 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AYR67_04375 ENOG4105HHA aminodeoxychorismate lyase AYR67_04390 ENOG4108IYU L-aspartate oxidase AYR67_04395 ENOG4105C0H protease AYR67_04410 ENOG4105C3F Signal peptidase i AYR67_04425 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AYR67_04435 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AYR67_04440 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AYR67_04445 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AYR67_04450 ENOG4105EMU Dehydrogenase AYR67_04485 ENOG4105BZU Histidine kinase AYR67_04495 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AYR67_04505 ENOG4105DTR rard protein AYR67_04540 ENOG4107QS8 (LipO)protein AYR67_04545 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AYR67_04550 ENOG4105EA8 2-Nitropropane dioxygenase AYR67_04580 ENOG4107R8N Glycosyl transferase, family 2 AYR67_04595 ENOG4105CVP deoxyribo-dipyrimidine photolyase AYR67_04600 ENOG4108YZY peptidylprolyl cis-trans isomerase AYR67_04605 ENOG4105CEP NADH dehydrogenase AYR67_04610 ENOG4105DZ1 carboxypeptidase AYR67_04620 ENOG4105E9K Isocitrate dehydrogenase AYR67_04625 ENOG4108R99 pseudouridine synthase AYR67_04645 ENOG4105CBP Major Facilitator AYR67_04650 ENOG4105EGI Transcriptional regulator AYR67_04655 ENOG4108ETY sodium dicarboxylate symporter AYR67_04660 ENOG4105JAB phenazine biosynthesis protein, phzf family AYR67_04690 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AYR67_04705 ENOG4105D3G Pseudouridine synthase AYR67_04710 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AYR67_04725 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AYR67_04750 ENOG4108JPW Aminotransferase AYR67_04755 ENOG4105DY8 decarboxylase AYR67_04765 ENOG4105F7P transcriptional regulator AsnC family AYR67_04770 ENOG4107RA9 decarboxylase AYR67_04775 ENOG4105C85 amino acid AYR67_04780 ENOG4105CVA phosphate AYR67_04785 ENOG4105C8U phosphate abc transporter AYR67_04795 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AYR67_04800 ENOG4105ERU peptidase AYR67_04810 ENOG4105D5G Transposase AYR67_04820 ENOG4107QTF adenylosuccinate lyase AYR67_04840 ENOG4108Z0R Transferase AYR67_04845 ENOG4105DZ1 carboxypeptidase AYR67_04865 ENOG4108K5P (LipO)protein AYR67_04870 ENOG4105EJC lysr family transcriptional regulator AYR67_04875 ENOG4105DAN ATP-dependent protease AYR67_04890 ENOG4105DHU Bile acid AYR67_04910 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AYR67_04920 ENOG4105D22 carbon starvation protein AYR67_04925 ENOG4105VCD cytoplasmic protein AYR67_04955 ENOG4108K8K Transcriptional regulator AYR67_04970 ENOG4105C26 Dehydrogenase AYR67_04975 ENOG4105C85 amino acid AYR67_04980 ENOG4105ETT transcriptional Regulator, LysR family AYR67_04985 ENOG4105C94 Transporter AYR67_04990 ENOG4105C94 Transporter AYR67_05000 ENOG4105C26 Dehydrogenase AYR67_05005 ENOG4107QZF nitrite reductase NADPH large subunit AYR67_05010 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AYR67_05040 ENOG41060M8 Pfam:PhdYeFM AYR67_05045 ENOG4107QNK )-transporter AYR67_05050 ENOG4107WEA mandelate racemase muconate lactonizing AYR67_05060 ENOG4105J7D transcriptional regulator AYR67_05075 ENOG4105C2I pirin domain protein AYR67_05085 ENOG4105WWK YheO domain protein AYR67_05100 ENOG4105CEY Amp-dependent synthetase and ligase AYR67_05115 ENOG4108IPW abc transporter atp-binding protein AYR67_05135 ENOG4105C0W non-ribosomal peptide synthetase AYR67_05140 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AYR67_05145 ENOG4105WQI isochorismatase AYR67_05160 ENOG4105BZ1 (ABC) transporter AYR67_05180 ENOG4105E4F Isochorismate synthase AYR67_05195 ENOG4105NX3 Membrane AYR67_05225 ENOG4105EUJ GTP cyclohydrolase i AYR67_05235 ENOG4105C7W Xanthine dehydrogenase AYR67_05265 ENOG4105CD8 aminopeptidase N AYR67_05270 ENOG4105DDQ anthranilate synthase AYR67_05280 ENOG4105DUX Transporter AYR67_05285 ENOG4105C5F glutamine synthetase AYR67_05295 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AYR67_05330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AYR67_05335 ENOG4107QNR UPF0135 protein AYR67_05340 ENOG4105C0H protease AYR67_05350 ENOG4105C6K Malic enzyme AYR67_05355 ENOG4105BZU Histidine kinase AYR67_05360 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AYR67_05365 ENOG4105SYT Methylenetetrahydrofolate reductase AYR67_05370 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AYR67_05385 ENOG4107QPN acyl-Coa dehydrogenase AYR67_05390 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AYR67_05395 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AYR67_05410 ENOG4107RNU major facilitator superfamily MFS_1 AYR67_05420 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AYR67_05425 ENOG4105CE9 30S ribosomal protein S2 AYR67_05465 ENOG4105CVE Lytic murein transglycosylase AYR67_05470 ENOG4105CNI cell division protein FtsW AYR67_05485 ENOG4105E3A (ABC) transporter AYR67_05490 ENOG4105DA5 (ABC) transporter AYR67_05525 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AYR67_05535 ENOG4105ENT Efflux transporter rnd family, mfp subunit AYR67_05545 ENOG4105E89 ABC transporter AYR67_05550 ENOG4105DSP amino acid AbC transporter AYR67_05555 ENOG4106YG3 ABC transporter AYR67_05560 ENOG4108JEH abc transporter atp-binding protein AYR67_05570 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AYR67_05575 ENOG4105CFP Peptidase U32 AYR67_05580 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AYR67_05585 ENOG4105JAB phenazine biosynthesis protein, phzf family AYR67_05590 ENOG4105DP0 ferredoxin-NADP reductase AYR67_05595 ENOG4108R96 Methyltransferase, YaeB family AYR67_05605 ENOG4107QHF type ii secretion system protein e AYR67_05615 ENOG4105XJC Two component transcriptional regulator (Winged helix family AYR67_05620 ENOG4105DHQ Histidine kinase AYR67_05630 ENOG4105M6F mutator MutT protein AYR67_05640 ENOG4105BZ4 penicillin-binding protein AYR67_05645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AYR67_05650 ENOG4105VUT cytoplasmic protein AYR67_05655 ENOG4107QYG anthranilate phosphoribosyltransferase AYR67_05660 ENOG4105CK2 sodium dicarboxylate symporter AYR67_05665 ENOG4105C1G acyl-Coa dehydrogenase AYR67_05670 ENOG4105NIV Esterase AYR67_05675 ENOG4105CQC Prephenate dehydratase AYR67_05680 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AYR67_05690 ENOG4105CIN aminoacyl-histidine dipeptidase AYR67_05695 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AYR67_05725 ENOG4105M08 Membrane AYR67_05730 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AYR67_05740 ENOG4105VEQ Cold shock protein AYR67_05745 ENOG4105C1J atp-dependent rna helicase AYR67_05755 ENOG41069NU Nitroreductase AYR67_05790 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AYR67_05805 ENOG4105C5I Dehydrogenase AYR67_05810 ENOG4105ERG peptidase m48, ste24p AYR67_05815 ENOG4105KTH gatB Yqey AYR67_05820 ENOG4105VCC 30S ribosomal protein S21 AYR67_05845 ENOG4105D9P serine threonine protein kinase AYR67_05870 ENOG4105EVZ LysR family transcriptional regulator AYR67_05875 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AYR67_05880 ENOG4105C26 Dehydrogenase AYR67_05915 ENOG4105H4F exported protein AYR67_05945 ENOG4105D6U Sodium Glutamate Symporter AYR67_05955 ENOG4105JXH GntR family transcriptional regulator AYR67_06005 ENOG4105CSH Transporter AYR67_06025 ENOG4105CEB Aspartate aminotransferase AYR67_06040 ENOG4105F1S paraquat-inducible protein a AYR67_06045 ENOG4105DY2 Paraquat-inducible protein b AYR67_06075 ENOG4105CK2 sodium dicarboxylate symporter AYR67_06085 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AYR67_06090 ENOG4108UMI ABC transporter, permease AYR67_06095 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AYR67_06105 ENOG4105C12 Phosphoribosylglycinamide synthetase AYR67_06110 ENOG4105DC1 bifunctional purine biosynthesis protein purh AYR67_06115 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AYR67_06165 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AYR67_06170 ENOG4105CDU Replicative dna helicase AYR67_06195 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AYR67_06200 ENOG4105CCU oxidase (Subunit III) AYR67_06205 ENOG4105BZ9 Cytochrome C oxidase, subunit I AYR67_06210 ENOG4105E2S oxidase) subunit II AYR67_06235 ENOG4107BJW polysaccharide deacetylase AYR67_06240 ENOG4105CND Glycosyl transferase, family 2 AYR67_06245 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD AYR67_06255 ENOG4105DEN Luciferase family AYR67_06270 ENOG4105CC0 LysR family Transcriptional regulator AYR67_06285 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AYR67_06290 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AYR67_06295 ENOG4105GVF (ABC) transporter AYR67_06310 ENOG4105C1G acyl-Coa dehydrogenase AYR67_06320 ENOG4108MEJ flavin reductase domain protein AYR67_06325 ENOG4105D06 uba thif-type nad fad binding protein AYR67_06345 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AYR67_06350 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AYR67_06360 ENOG4105C08 Histidine kinase AYR67_06365 ENOG4105EEX Two component transcriptional regulator (Winged helix family AYR67_06370 ENOG4105CFQ glutamine synthetase AYR67_06385 ENOG4107S74 Lysophospholipid transporter LplT AYR67_06390 ENOG4105CFU surface antigen AYR67_06405 ENOG4107QIJ Aconitate hydratase 2 AYR67_06415 ENOG4105EYW Ion transport protein AYR67_06420 ENOG4105F27 Major Facilitator AYR67_06435 ENOG4105DZ2 Transcriptional regulator AYR67_06470 ENOG4105K8N protein family UPF0079, ATPase AYR67_06475 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AYR67_06485 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AYR67_06490 ENOG4108TZV Membrane AYR67_06495 ENOG4108RCM Nitroreductase AYR67_06505 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AYR67_06520 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AYR67_06525 ENOG4107FQ9 ethanolamine ammonia-lyase AYR67_06530 ENOG4105CPD ethanolamine ammonia-lyase AYR67_06535 ENOG4107R55 ethanolamine transporter AYR67_06545 ENOG4107RR1 TRANSCRIPTIONal AYR67_06555 ENOG4105C0A alcohol dehydrogenase AYR67_06560 ENOG4107QUV Domain protein AYR67_06570 ENOG4105F4I Transcriptional regulator AYR67_06590 ENOG4105CD8 aminopeptidase N AYR67_06625 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) AYR67_06630 ENOG4105EW9 transcriptional regulator AsnC family AYR67_06640 ENOG4105R8C Transcriptional regulator AYR67_06650 ENOG4105CUY Mechanosensitive ion channel AYR67_06690 ENOG4105CNM Receptor AYR67_06710 ENOG4105C5H ABC transporter AYR67_06715 ENOG41081QV Universal stress protein AYR67_06735 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AYR67_06745 ENOG4105DKK Benzoate AYR67_06750 ENOG4105EW9 transcriptional regulator AsnC family AYR67_06755 ENOG4108NIW Leucine export protein LeuE AYR67_06760 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AYR67_06765 ENOG4105C5Q Transcriptional regulator AYR67_06775 ENOG4105CHU acetyl-coa acetyltransferase AYR67_06780 ENOG4105CHR reductase AYR67_06805 ENOG4107QMP dna polymerase iii subunits gamma and tau AYR67_06810 ENOG4105HSS phospholipase C AYR67_06820 ENOG4105C0A alcohol dehydrogenase AYR67_06850 ENOG4105CBC glutamate synthase AYR67_07035 ENOG4105VTN Protein of unknown function (DUF1311) AYR67_07185 ENOG4105K4U addiction module toxin, RelE StbE family AYR67_07225 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AYR67_07370 ENOG4105D8G Major Facilitator superfamily AYR67_07380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AYR67_07385 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AYR67_07405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AYR67_07415 ENOG4107QZF nitrite reductase NADPH large subunit AYR67_07420 ENOG4108IFG nitrite reductase, (NAD(P)H) AYR67_07440 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AYR67_07455 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AYR67_07460 ENOG4105CVM Molybdenum cofactor synthesis domain protein AYR67_07470 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AYR67_07475 ENOG4105T38 integral membrane protein AYR67_07495 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AYR67_07500 ENOG4105CMR udp-glucose 4-epimerase AYR67_07515 ENOG4108R0M Aminoglycoside AYR67_07575 ENOG4105F6A helicase AYR67_07595 ENOG4105CHH sulfate transporter AYR67_07685 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AYR67_07690 ENOG4105CUX Signal transduction histidine kinase AYR67_07710 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AYR67_07715 ENOG4105KNE Phosphatidate cytidylyltransferase AYR67_07725 ENOG4105DZP Membrane-associated zinc metalloprotease AYR67_07750 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AYR67_07765 ENOG4105Y3E Modulates RecA activity (By similarity) AYR67_07775 ENOG4105VEJ Heat shock protein AYR67_07780 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AYR67_07805 ENOG4105F7P transcriptional regulator AsnC family AYR67_07815 ENOG4105C85 amino acid AYR67_07830 ENOG4105CHH sulfate transporter AYR67_07835 ENOG4108RAV Conserved protein AYR67_07840 ENOG4105D8V Glucose sorbosone dehydrogenase AYR67_07850 ENOG4105BZU Histidine kinase AYR67_07870 ENOG4105DM4 PTS System AYR67_07875 ENOG4105DE4 1-phosphofructokinase AYR67_07880 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AYR67_07905 ENOG4105CWM branched-chain amino acid transport system II carrier protein AYR67_07910 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AYR67_07915 ENOG4105CC0 LysR family Transcriptional regulator AYR67_07925 ENOG4105M2J Glutaredoxin AYR67_07930 ENOG4105C8Y Acetylornithine aminotransferase AYR67_07935 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AYR67_07960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AYR67_07970 ENOG41068P6 UPF0319 protein AYR67_07990 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AYR67_07995 ENOG4105C4M (Ubiquinol oxidase) subunit I AYR67_08005 ENOG4105PV3 Inner membrane protein yqiJ AYR67_08020 ENOG4105E0K tonB-dependent siderophore receptor AYR67_08030 ENOG4105HDD phospholipase AYR67_08035 ENOG4105CZN Potassium uptake protein AYR67_08045 ENOG4105C7B Threonine dehydratase AYR67_08075 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AYR67_08080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AYR67_08090 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AYR67_08105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AYR67_08150 ENOG4107VMU Membrane AYR67_08155 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AYR67_08165 ENOG4107QP7 CoA-transferase subunit A AYR67_08170 ENOG4107QNJ CoA-transferase subunit B AYR67_08175 ENOG4105CHU acetyl-coa acetyltransferase AYR67_08180 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AYR67_08185 ENOG4105F2Z 3-oxoadipate enol-lactonase AYR67_08190 ENOG4105D2S major facilitator superfamily AYR67_08195 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AYR67_08200 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta AYR67_08205 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha AYR67_08210 ENOG4105FF2 Type I DHQase AYR67_08215 ENOG4106JPM 3-dehydroshikimate dehydratase AYR67_08220 ENOG4105TW1 Carbohydrate-selective porin OprB AYR67_08225 ENOG4105DZG Dehydrogenase AYR67_08235 ENOG4105MD1 YeeE YedE family protein AYR67_08250 ENOG4107HP6 Transcriptional regulator AYR67_08255 ENOG4108PTX LysR family Transcriptional regulator AYR67_08260 ENOG4105C1G acyl-Coa dehydrogenase AYR67_08285 ENOG4105DNH Major Facilitator AYR67_08295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AYR67_08315 ENOG4105FUY alpha subunit AYR67_08325 ENOG4105CHR reductase AYR67_08345 ENOG4105F11 amine oxidase AYR67_08355 ENOG4105C26 Dehydrogenase AYR67_08365 ENOG4105F2Z 3-oxoadipate enol-lactonase AYR67_08370 ENOG4105CHU acetyl-coa acetyltransferase AYR67_08375 ENOG4107QNJ CoA-transferase subunit B AYR67_08380 ENOG4107QP7 CoA-transferase subunit A AYR67_08390 ENOG4105NN7 muconolactone delta-isomerase AYR67_08395 ENOG4105DTQ mandelate racemase muconate lactonizing AYR67_08400 ENOG4108KB2 LysR family Transcriptional regulator AYR67_08410 ENOG4107EJG GntR family transcriptional regulator AYR67_08430 ENOG4105CZJ Aldehyde dehydrogenase AYR67_08450 ENOG4105C1G acyl-Coa dehydrogenase AYR67_08455 ENOG4105CHR reductase AYR67_08460 ENOG4108JU7 Transcriptional regulator AYR67_08470 ENOG41062QD Membrane AYR67_08485 ENOG4107RGH Aldehyde dehydrogenase AYR67_08500 ENOG4105CH6 catalase AYR67_08525 ENOG4105K56 Transcriptional regulator AYR67_08530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AYR67_08540 ENOG4105NAE bifunctional deaminase-reductase domain protein AYR67_08570 ENOG4107Z3H Transcriptional regulator, TetR family AYR67_08580 ENOG4105CHJ isochorismatase hydrolase AYR67_08585 ENOG4105EJC lysr family transcriptional regulator AYR67_08590 ENOG4105D8V Glucose sorbosone dehydrogenase AYR67_08595 ENOG4105CKD glutathione-regulated potassium-efflux system protein AYR67_08605 ENOG4105CH2 amidohydrolase AYR67_08615 ENOG4105D5K Hemolysin activator protein AYR67_08620 ENOG4105CKT filamentous hemagglutinin AYR67_08650 ENOG4105FDP GntR family transcriptional regulator AYR67_08670 ENOG4106KR7 LysR family Transcriptional regulator AYR67_08695 ENOG4108JQ1 Dehydrogenase AYR67_08700 ENOG4105JSC dimethylmenaquinone methyltransferase AYR67_08720 ENOG4105CW7 secretion protein, HlyD family AYR67_08735 ENOG4105CZJ Aldehyde dehydrogenase AYR67_08740 ENOG4105C01 Dihydroxy-acid dehydratase AYR67_08750 ENOG4105DDW LysR family Transcriptional regulator AYR67_08755 ENOG4105EXW epimerase dehydratase AYR67_08765 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AYR67_08770 ENOG4105CF7 AraC family transcriptional regulator AYR67_08785 ENOG4105DQ4 alcohol dehydrogenase AYR67_08795 ENOG4105EHG Permease protein AYR67_08800 ENOG4105E0A ABC, transporter AYR67_08820 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AYR67_08895 ENOG4108UAJ Transcriptional regulator AYR67_08935 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AYR67_08985 ENOG4108BAS reductase AYR67_09000 ENOG4108R6W Transcriptional regulator, ARAC family AYR67_09005 ENOG4108821 RND type efflux pump AYR67_09010 ENOG4105E0F Histidine kinase AYR67_09015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AYR67_09020 ENOG4105C1P efflux transporter, rnd family, mfp subunit AYR67_09025 ENOG4105BZS acriflavin resistance protein AYR67_09030 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AYR67_09040 ENOG4105CT3 Monooxygenase AYR67_09060 ENOG4105CJP fad dependent oxidoreductase AYR67_09080 ENOG4105X0I Fimbrial AYR67_09140 ENOG4107RZC phospholipase d AYR67_09160 ENOG4108IGT Dipeptidase AYR67_09190 ENOG4107T31 5'-nucleotidase AYR67_09200 ENOG4105WQI isochorismatase AYR67_09205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AYR67_09210 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AYR67_09215 ENOG4105E0C molybdate abc transporter AYR67_09220 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AYR67_09225 ENOG4105F4R Transcriptional regulator mode AYR67_09230 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit AYR67_09235 ENOG4108YS2 small subunit AYR67_09240 ENOG4105F57 Anthranilate dioxygenase reductase AYR67_09265 ENOG4105CHR reductase AYR67_09280 ENOG4105CF7 AraC family transcriptional regulator AYR67_09295 ENOG4105DTD Dehydrogenase AYR67_09300 ENOG4105CY2 Citrate transporter AYR67_09310 ENOG4108M0I Transcriptional regulator AYR67_09320 ENOG4107QNJ CoA-transferase subunit B AYR67_09325 ENOG4105CRW Short chain fatty acid transporter AYR67_09330 ENOG4105CHU acetyl-coa acetyltransferase AYR67_09340 ENOG4107YNJ LysR family Transcriptional regulator AYR67_09355 ENOG4108IJ0 Aspartate ammonia-lyase AYR67_09365 ENOG4105CSH Transporter AYR67_09385 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AYR67_09390 ENOG4106FTQ Taurine ABC transporter, periplasmic AYR67_09405 ENOG4105FDP GntR family transcriptional regulator AYR67_09415 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AYR67_09420 ENOG4105KVH Transcriptional regulator AYR67_09425 ENOG4105UEI Transcriptional Regulator AraC Family AYR67_09440 ENOG4108VCT Sulfite exporter TauE/SafE AYR67_09450 ENOG4107QPB Beta-lactamase domain protein AYR67_09460 ENOG4105FFC UPF0187 protein AYR67_09470 ENOG4105CHR reductase AYR67_09485 ENOG4105CPP Dehydrogenase, E1 component AYR67_09490 ENOG4107R0V Pyruvate dehydrogenase AYR67_09495 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AYR67_09510 ENOG4105BZU Histidine kinase AYR67_09520 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AYR67_09525 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AYR67_09570 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AYR67_09585 ENOG4105C28 cystathionine AYR67_09595 ENOG4105F2W methyltransferase AYR67_09625 ENOG4105K59 histidine triad (HIT) protein AYR67_09660 ENOG4107QWP ABC-2 type transporter AYR67_09665 ENOG4107QWP ABC-2 type transporter AYR67_09670 ENOG4105CJ1 ABC, transporter AYR67_09685 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AYR67_09690 ENOG4105CNM Receptor AYR67_09710 ENOG4107TSN permease AYR67_09715 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AYR67_09735 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AYR67_09740 ENOG4108YZT Adenosylcobinamide kinase AYR67_09750 ENOG4107VXZ Hydrolase AYR67_09790 ENOG4105DJU Siderophore biosynthesis protein AYR67_09795 ENOG4105DUU IucA IucC family protein AYR67_09815 ENOG4108Z66 YbaK ebsC protein AYR67_09830 ENOG4105C1G acyl-Coa dehydrogenase AYR67_09835 ENOG4105C1G acyl-Coa dehydrogenase AYR67_09840 ENOG4105EEF Alkane 1-monooxygenase AYR67_09845 ENOG4105E7U AraC family transcriptional regulator AYR67_09850 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AYR67_09855 ENOG4105K70 DNA-binding protein AYR67_09870 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AYR67_09880 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AYR67_09885 ENOG4108Z4V iron-sulfur cluster assembly AYR67_09900 ENOG4108ZIT Ferredoxin, 2FE-2S AYR67_09905 ENOG4105F8J Adenylate Guanylate cyclase AYR67_09915 ENOG4108JA2 transcriptioN-repair coupling factor AYR67_09935 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AYR67_09940 ENOG4105K4T epimerase AYR67_09955 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AYR67_09975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AYR67_09985 ENOG4105DGW oligopeptidase A AYR67_10020 ENOG4105SG9 biopolymer transport protein, ExbD AYR67_10030 ENOG4107QP3 malate synthase g AYR67_10035 ENOG4105D6Z AFG1 family ATPase AYR67_10045 ENOG4107RN6 Monooxygenase AYR67_10065 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AYR67_10070 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AYR67_10085 ENOG4108Z6B deaminase AYR67_10105 ENOG4108RTD type II secretion system protein K AYR67_10130 ENOG4105F8V Hydrolase, tatD family AYR67_10140 ENOG4107QRG dna polymerase iii AYR67_10150 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AYR67_10155 ENOG4105BZ1 (ABC) transporter AYR67_10170 ENOG4105FA0 parb-like partition protein AYR67_10175 ENOG4107QJE Chromosome Partitioning Protein AYR67_10185 ENOG4108S0S Nucleotidyl transferase AYR67_10190 ENOG4105EHM Aminoglycoside phosphotransferase AYR67_10195 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AYR67_10200 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AYR67_10205 ENOG4105D2N Aldolase AYR67_10225 ENOG4108UHJ MAF-like protein AYR67_10230 ENOG4105EZE Cupin 4 family protein AYR67_10240 ENOG41080HT Transcriptional regulator, arsr family AYR67_10250 ENOG4105XPP Protein of unknown function (DUF1275) AYR67_10255 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AYR67_10260 ENOG4105BZ1 (ABC) transporter AYR67_10270 ENOG4108ZX5 transcriptional regulator AYR67_10280 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AYR67_10285 ENOG4105CK7 Sodium proline symporter AYR67_10290 ENOG4105EW9 transcriptional regulator AsnC family AYR67_10295 ENOG4105C26 Dehydrogenase AYR67_10300 ENOG4105YGK Pfam:UPF0157 AYR67_10315 ENOG4108T58 Mg2 transport protein CorA AYR67_10325 ENOG4108YYC ycei family AYR67_10335 ENOG4105CV1 Transketolase (EC 2.2.1.1) AYR67_10360 ENOG4108HWY Beta-lactamase AYR67_10380 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AYR67_10385 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AYR67_10405 ENOG4105X0I Fimbrial AYR67_10410 ENOG4105GQR Chaperone AYR67_10435 ENOG4108IPJ Membrane AYR67_10445 ENOG4105ETS cytosine purines uracil thiamine allantoin AYR67_10455 ENOG4105CC0 LysR family Transcriptional regulator AYR67_10475 ENOG41067SE Tetr family transcriptional regulator AYR67_10490 ENOG4105EW9 transcriptional regulator AsnC family AYR67_10500 ENOG4105CDA abc transporter atp-binding protein AYR67_10505 ENOG4105DRP amino acid AbC transporter AYR67_10510 ENOG4105EAD ABC transporter AYR67_10525 ENOG4107T8P acyl-Coa dehydrogenase AYR67_10540 ENOG4105D01 (LipO)protein AYR67_10545 ENOG4105D01 (LipO)protein AYR67_10550 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AYR67_10555 ENOG4108UMI ABC transporter, permease AYR67_10560 ENOG4105C3G gtp-binding protein AYR67_10585 ENOG4108UMN azlc family AYR67_10590 ENOG4105ZED uncharacterized protein ygaH AYR67_10620 ENOG4105E7U AraC family transcriptional regulator AYR67_10625 ENOG4108V06 Glutathione peroxidase AYR67_10635 ENOG4105CHM Aminotransferase AYR67_10650 ENOG4105C0B DNA polymerase III (alpha subunit) AYR67_10675 ENOG4108JU3 Alkyl hydroperoxide reductase AYR67_10690 ENOG4108KB2 LysR family Transcriptional regulator AYR67_10695 ENOG4105D6J arsenicaL-resistance protein AYR67_10700 ENOG41082YX Transcriptional regulator, arsr family AYR67_10715 ENOG4105CPN adenine deaminase AYR67_10725 ENOG4105CBN LysR family transcriptional regulator AYR67_10735 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AYR67_10745 ENOG4105E2B Taurine dioxygenase AYR67_10750 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AYR67_10755 ENOG4108IY8 ABC, transporter AYR67_10760 ENOG4106FTQ Taurine ABC transporter, periplasmic AYR67_10770 ENOG4105C54 Major Facilitator superfamily AYR67_10790 ENOG4105C4M (Ubiquinol oxidase) subunit I AYR67_10795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AYR67_10805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AYR67_10810 ENOG4108K70 Transcriptional regulator AYR67_10825 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AYR67_10830 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase AYR67_10845 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) AYR67_10850 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AYR67_10860 ENOG4105DXI Major Facilitator superfamily AYR67_10880 ENOG41067MG lrgb family AYR67_10885 ENOG4105VAW lrga family AYR67_10890 ENOG4105CMU LysR family (Transcriptional regulator AYR67_10895 ENOG4108SHQ Glutathione S-transferase AYR67_10900 ENOG4105CYM Glutathione S-transferase AYR67_10905 ENOG4105CBN LysR family transcriptional regulator AYR67_10910 ENOG4105CHR reductase AYR67_10920 ENOG4105D7W serine acetyltransferase AYR67_10925 ENOG4105ESN nucleotide-binding protein AYR67_10930 ENOG4105C9B Cysteine desulfurase AYR67_10940 ENOG4105EXG Transcriptional regulator AYR67_10945 ENOG4105CT1 (ABC) transporter AYR67_10950 ENOG4107RP9 extracellular solute-binding protein, family 3 AYR67_10955 ENOG4105CDA abc transporter atp-binding protein AYR67_10960 ENOG4108HW4 amino acid AbC transporter AYR67_10965 ENOG4105EAD ABC transporter AYR67_10975 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AYR67_10980 ENOG4105BZU Histidine kinase AYR67_10990 ENOG4105EW9 transcriptional regulator AsnC family AYR67_11000 ENOG4105KT5 UmuD protein AYR67_11020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AYR67_11070 ENOG4105HEI LysR family (Transcriptional regulator AYR67_11090 ENOG4105CEY Amp-dependent synthetase and ligase AYR67_11095 ENOG4105R8C Transcriptional regulator AYR67_11100 ENOG4105C1G acyl-Coa dehydrogenase AYR67_11105 ENOG4107QX3 carboxylase AYR67_11110 ENOG4105E39 Enoyl-CoA hydratase AYR67_11125 ENOG4105CC0 LysR family Transcriptional regulator AYR67_11140 ENOG4105CSU acyl-Coa dehydrogenase AYR67_11150 ENOG4105EQ0 Major Facilitator superfamily AYR67_11160 ENOG4107QNJ CoA-transferase subunit B AYR67_11165 ENOG4107QP7 CoA-transferase subunit A AYR67_11170 ENOG4107RGD Major Facilitator superfamily AYR67_11175 ENOG4105C1G acyl-Coa dehydrogenase AYR67_11180 ENOG4105E39 Enoyl-CoA hydratase AYR67_11185 ENOG4105CHR reductase AYR67_11190 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AYR67_11195 ENOG4105CHU acetyl-coa acetyltransferase AYR67_11205 ENOG4105EQ0 Major Facilitator superfamily AYR67_11210 ENOG4105EA8 2-Nitropropane dioxygenase AYR67_11215 ENOG4108UKI Enoyl-CoA hydratase AYR67_11230 ENOG4105C1G acyl-Coa dehydrogenase AYR67_11235 ENOG4107RGD Major Facilitator superfamily AYR67_11240 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AYR67_11245 ENOG4107STF Involved in phosphonate degradation (By similarity) AYR67_11255 ENOG4107RCV ABC transporter, permease AYR67_11260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AYR67_11265 ENOG4105C4Y ABC transporter AYR67_11275 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AYR67_11280 ENOG4107HP6 Transcriptional regulator AYR67_11290 ENOG4105HEI LysR family (Transcriptional regulator AYR67_11295 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AYR67_11300 ENOG4105C26 Dehydrogenase AYR67_11310 ENOG4105ETS cytosine purines uracil thiamine allantoin AYR67_11315 ENOG4105C26 Dehydrogenase AYR67_11320 ENOG4108M8W Monooxygenase AYR67_11325 ENOG4105MXW flavin reductase domain protein, FMN-binding AYR67_11330 ENOG4108MXF Alpha Beta Hydrolase AYR67_11350 ENOG4105CPW cytochrome b561 AYR67_11355 ENOG4107VGR Catalase AYR67_11390 ENOG4107YAU phenylacetic acid degradation protein AYR67_11400 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AYR67_11405 ENOG4105DZS Phenylacetate-CoA ligase AYR67_11410 ENOG4105CHU acetyl-coa acetyltransferase AYR67_11415 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AYR67_11420 ENOG4108UKI Enoyl-CoA hydratase AYR67_11425 ENOG4105E39 Enoyl-CoA hydratase AYR67_11430 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AYR67_11435 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AYR67_11440 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AYR67_11445 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AYR67_11450 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AYR67_11455 ENOG4105DXM phenylacetic acid degradation protein AYR67_11460 ENOG4105EJQ L-serine dehydratase AYR67_11465 ENOG4107QTZ amino acid AYR67_11470 ENOG4105CZJ Aldehyde dehydrogenase AYR67_11495 ENOG4105MWK D-amino acid dehydrogenase, small subunit AYR67_11515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AYR67_11525 ENOG4108Z4X TRANSCRIPTIONal AYR67_11545 ENOG4105WPN DNA integration recombination invertion protein AYR67_11560 ENOG4105DJ2 Major Facilitator Superfamily AYR67_11565 ENOG4107Y2X deaminase AYR67_11575 ENOG4105EMY transcriptional regulator AYR67_11605 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AYR67_11620 ENOG4105UYK outer membrane protein a AYR67_11690 ENOG4108HW3 (ABC) transporter AYR67_11700 ENOG4105MRR Transcriptional regulator (By similarity) AYR67_11715 ENOG4105KVH Transcriptional regulator AYR67_11720 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF AYR67_11725 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AYR67_11740 ENOG4105E2A Dehydrogenase AYR67_11750 ENOG4105R8C Transcriptional regulator AYR67_11775 ENOG4107R4J Chloride channel AYR67_11780 ENOG4108JIK carboxylase AYR67_11800 ENOG4105C5A transporter AYR67_11805 ENOG4108WAV Transcriptional regulator AYR67_11820 ENOG4105CNA YD repeat protein AYR67_11850 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AYR67_11870 ENOG4105D2S major facilitator superfamily AYR67_11880 ENOG4105D1S lipid A biosynthesis AYR67_11885 ENOG4105BZU Histidine kinase AYR67_11890 ENOG4107AQZ Membrane AYR67_11910 ENOG4108Z4U Ferredoxin AYR67_11950 ENOG4105DFG type I secretion outer membrane protein AYR67_11955 ENOG4108IUZ ABC transporter AYR67_11960 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AYR67_11970 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AYR67_11975 ENOG4105C2X Arabinose 5-phosphate isomerase AYR67_12010 ENOG4107YPT transcriptional regulator AYR67_12035 ENOG4105II7 pyrroline-5-carboxylate reductase AYR67_12045 ENOG4105VEQ Cold shock protein AYR67_12050 ENOG410829K Lysine exporter protein (Lyse ygga) AYR67_12085 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AYR67_12135 ENOG4108KB2 LysR family Transcriptional regulator AYR67_12140 ENOG4105FUY alpha subunit AYR67_12145 ENOG4108UKV benzoate 1,2-dioxygenase AYR67_12150 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AYR67_12155 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase AYR67_12160 ENOG4105DKK Benzoate AYR67_12165 ENOG4105D2S major facilitator superfamily AYR67_12180 ENOG4105CQ7 ATP-dependent helicase AYR67_12185 ENOG4105D3R alkyl hydroperoxide reductase AYR67_12195 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AYR67_12205 ENOG4108JU3 Alkyl hydroperoxide reductase AYR67_12215 ENOG4108K3A Glutathione S-transferase AYR67_12225 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AYR67_12230 ENOG4108TGY Glutathione S-transferase AYR67_12240 ENOG4108ZG0 Ompa motb domain protein AYR67_12245 ENOG4105CD3 dihydroorotase AYR67_12275 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AYR67_12290 ENOG4108UKZ OsmC family AYR67_12295 ENOG4107RYR Transcriptional regulator, Crp Fnr family AYR67_12310 ENOG4105CPC Aldo Keto reductase AYR67_12325 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AYR67_12335 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AYR67_12345 ENOG4105CFH Aspartokinase AYR67_12355 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AYR67_12365 ENOG4105CPW cytochrome b561 AYR67_12370 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AYR67_12375 ENOG4105C7N Xanthine uracil vitamin C permease AYR67_12385 ENOG4105F95 Monooxygenase AYR67_12430 ENOG4108C33 Resolvase AYR67_12435 ENOG4105D13 transposase AYR67_12470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AYR67_12490 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AYR67_12510 ENOG4108JQ5 ABC transporter AYR67_12515 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AYR67_12520 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AYR67_12530 ENOG4105E9H Lytic Murein transglycosylase AYR67_12530 ENOG4105E9H Lytic Murein transglycosylase AYR67_12535 ENOG4107RZZ dna polymerase iii epsilon subunit AYR67_12545 ENOG4105E09 nadh pyrophosphatase AYR67_12555 ENOG4105W4M Transport-associated protein AYR67_12565 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AYR67_12575 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AYR67_12580 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AYR67_12600 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AYR67_12605 ENOG4105D0A hydroxylase AYR67_12610 ENOG4107RAQ aminopeptidase AYR67_12745 ENOG4105EFC phage portal protein HK97 family AYR67_12835 ENOG4105CDU Replicative dna helicase AYR67_12855 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AYR67_12910 ENOG4105DIJ Phosphoethanolamine transferase AYR67_12955 ENOG4105DR5 peptidase AYR67_13270 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AYR67_13295 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AYR67_13305 ENOG4105D82 Glutamate dehydrogenase AYR67_13310 ENOG4108R3D Electron transport complex AYR67_13315 ENOG4105CSM endonuclease III AYR67_13335 ENOG4105CJN penicillin-binding protein AYR67_13340 ENOG4106H78 methyltransferase AYR67_13355 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AYR67_13365 ENOG4105CQM Urea amidohydrolase subunit alpha AYR67_13395 ENOG4107RET Isocitrate lyase AYR67_13405 ENOG4105C37 (CBS) domain AYR67_13415 ENOG4105D4T Citrate transporter AYR67_13430 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AYR67_13450 ENOG4108MRJ AYR67_13470 ENOG4105VCQ rubredoxin AYR67_13475 ENOG4107QZF nitrite reductase NADPH large subunit AYR67_13485 ENOG4105C5Q Transcriptional regulator AYR67_13505 ENOG4107U91 Rhomboid family AYR67_13510 ENOG4105CV6 ABC transporter, permease AYR67_13515 ENOG4108I0Y (ABC) transporter AYR67_13520 ENOG4108UJV acyl-CoA thioesterase i AYR67_13540 ENOG4107RNH Outer membrane receptor FepA AYR67_13555 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AYR67_13560 ENOG4105E6M Sulphatase-modifying factor protein AYR67_13580 ENOG4105CJ3 phosphate transporter AYR67_13645 ENOG4105DFP Integrase AYR67_13655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AYR67_13660 ENOG4105C0R drug resistance transporter emrb qaca subfamily AYR67_13665 ENOG4105CW7 secretion protein, HlyD family AYR67_13670 ENOG4108VUY thioesterase Superfamily protein AYR67_13675 ENOG4105D52 delta-aminolevulinic acid dehydratase AYR67_13680 ENOG4105MWK D-amino acid dehydrogenase, small subunit AYR67_13685 ENOG4105ECP epimerase AYR67_13705 ENOG4107RH8 nuclease SbcCD subunit D AYR67_13710 ENOG4105EYH Exonuclease AYR67_13715 ENOG4105DFA alanine racemase domain protein AYR67_13720 ENOG4105CZX twitching motility protein AYR67_13725 ENOG4105CZX twitching motility protein AYR67_13730 ENOG41090R7 Ferric uptake AYR67_13760 ENOG4105E7A Glutamine amidotransferase AYR67_13775 ENOG4107QKV phosphomannomutase AYR67_13785 ENOG4105C4R Atp-dependent dna helicase AYR67_13790 ENOG4108ZG0 Ompa motb domain protein AYR67_13795 ENOG4106HNH Acyl-transferase AYR67_13810 ENOG4107QMS site-determining protein AYR67_13835 ENOG4105CNU cell division protein FtsK AYR67_13840 ENOG4105C3M thioredoxin reductase AYR67_13845 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AYR67_13855 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AYR67_13900 ENOG4108YXA Membrane AYR67_13905 ENOG4105EUB pirin domain protein AYR67_13915 ENOG4105C4K Nad synthetase AYR67_13930 ENOG4105E3J oxidoreductase AYR67_13935 ENOG4105C26 Dehydrogenase AYR67_13940 ENOG4105DVW rieske (2Fe-2S) AYR67_13950 ENOG4105C94 Transporter AYR67_13955 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AYR67_13960 ENOG4105EJC lysr family transcriptional regulator AYR67_13980 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AYR67_14000 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AYR67_14005 ENOG4105C34 Pseudouridine synthase AYR67_14010 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AYR67_14015 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AYR67_14030 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AYR67_14060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AYR67_14090 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AYR67_14100 ENOG4105DWF phosphomethylpyrimidine kinase AYR67_14105 ENOG4109066 lysm domain bon superfamily protein AYR67_14115 ENOG4105CHR reductase AYR67_14120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AYR67_14130 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AYR67_14135 ENOG4108BPE -transporting atpase AYR67_14140 ENOG4107RTD sua5 ycio yrdc ywlc family protein AYR67_14145 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AYR67_14150 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AYR67_14155 ENOG4105FE9 pseudouridine synthase AYR67_14165 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AYR67_14170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AYR67_14180 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AYR67_14185 ENOG4108K4C ec 3.1.3.12 AYR67_14190 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AYR67_14195 ENOG4106UW1 Major Facilitator superfamily AYR67_14215 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AYR67_14225 ENOG4105HF0 Membrane AYR67_14240 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AYR67_14250 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AYR67_14300 ENOG4105D1F ATP-binding protein AYR67_14310 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AYR67_14340 ENOG4105K6H D-cysteine desulfhydrase AYR67_14345 ENOG4105CBX hi0933 family AYR67_14370 ENOG4105DP0 ferredoxin-NADP reductase AYR67_14375 ENOG4105DUM transcriptional regulator, lysR family AYR67_14395 ENOG4105C8S subunit m AYR67_14400 ENOG4105D65 subunit l AYR67_14410 ENOG4107UFS subunit j AYR67_14425 ENOG4108IEH NADH dehydrogenase subunit g AYR67_14430 ENOG4107QIZ NADH dehydrogenase AYR67_14435 ENOG4105GKE subunit e AYR67_14455 ENOG4105BZU Histidine kinase AYR67_14465 ENOG4105E0F Histidine kinase AYR67_14470 ENOG4107EXC regulatoR AYR67_14480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AYR67_14490 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AYR67_14500 ENOG4105EB3 Histidine kinase AYR67_14570 ENOG4105DZG Dehydrogenase AYR67_14590 ENOG4105JAB phenazine biosynthesis protein, phzf family AYR67_14615 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) AYR67_14620 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AYR67_14630 ENOG4105ETT transcriptional Regulator, LysR family AYR67_14660 ENOG4105CH2 amidohydrolase AYR67_14670 ENOG4106P55 Transcriptional regulator AYR67_14685 ENOG4106P55 Transcriptional regulator AYR67_14690 ENOG4107EFR Flavocytochrome c AYR67_14700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AYR67_14705 ENOG4107RGD Major Facilitator superfamily AYR67_14710 ENOG4105C1G acyl-Coa dehydrogenase AYR67_14715 ENOG4105ETT transcriptional Regulator, LysR family AYR67_14750 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AYR67_14755 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AYR67_14760 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AYR67_14775 ENOG4105VR0 copper resistance AYR67_14780 ENOG4105E3B Multicopper oxidase AYR67_14790 ENOG4108HCJ Hydrolase AYR67_14795 ENOG4105DJV ribulose-phosphate 3-epimerase AYR67_14820 ENOG41072GX Peptidase M22 Glycoprotease AYR67_14825 ENOG4108Z0R Transferase AYR67_14875 ENOG4105CRQ synthase (Component I) AYR67_14885 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AYR67_14890 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AYR67_14895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AYR67_14965 ENOG4105K56 Transcriptional regulator AYR67_14970 ENOG4108ZHJ Organic hydroperoxide resistance protein AYR67_14975 ENOG4107QHF type ii secretion system protein e AYR67_15010 ENOG4105C2M dna polymerase I AYR67_15015 ENOG4108VIA integral membrane protein AYR67_15020 ENOG4105II7 pyrroline-5-carboxylate reductase AYR67_15025 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AYR67_15035 ENOG4105C9X ppx gppa phosphatase AYR67_15045 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AYR67_15060 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AYR67_15085 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AYR67_15100 ENOG4105W39 Membrane AYR67_15105 ENOG4105CYM Glutathione S-transferase AYR67_15120 ENOG4105CEY Amp-dependent synthetase and ligase AYR67_15125 ENOG4105N42 UPF0307 protein AYR67_15130 ENOG41080Z8 PHOSPHOCARRIER protein AYR67_15150 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AYR67_15155 ENOG4105DJ0 Poly(A) Polymerase AYR67_15160 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AYR67_15165 ENOG4105DXN mazG family AYR67_15175 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AYR67_15190 ENOG4105C6T cysteine synthase AYR67_15195 ENOG4105BZU Histidine kinase AYR67_15200 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase AYR67_15205 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AYR67_15210 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AYR67_15225 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AYR67_15230 ENOG4105W8H transhydrogenase (subunit alpha AYR67_15235 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AYR67_15240 ENOG4106UX7 integral membrane protein AYR67_15255 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AYR67_15265 ENOG4107RSM transcriptional regulator AYR67_15270 ENOG4105CUZ uba thif-type nad fad binding protein AYR67_15280 ENOG4107QM5 aconitate hydratase AYR67_15285 ENOG4105F8V Hydrolase, tatD family AYR67_15300 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AYR67_15320 ENOG4105BZU Histidine kinase AYR67_15330 ENOG4108ZP8 Acetolactate synthase small subunit AYR67_15335 ENOG4105C7K acetolactate synthase AYR67_15360 ENOG4105DJY efflux transporter, rnd family, mfp subunit AYR67_15365 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AYR67_15370 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AYR67_15375 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AYR67_15385 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AYR67_15390 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AYR67_15400 ENOG4105VW4 glutaredoxin 3 AYR67_15420 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AYR67_15425 ENOG4105C2D reductase AYR67_15435 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AYR67_15465 ENOG4105C84 Histidine ammonia-lyase AYR67_15480 ENOG4105CEY Amp-dependent synthetase and ligase AYR67_15495 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AYR67_15515 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AYR67_15535 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) AYR67_15555 ENOG4105WVQ Fe-S assembly protein IscX AYR67_15570 ENOG4105CN1 protease AYR67_15585 ENOG4106HB6 Alpha beta hydrolase AYR67_15595 ENOG4105C26 Dehydrogenase AYR67_15600 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AYR67_15605 ENOG4105C6Z Gluconate AYR67_15610 ENOG4108UHU Aldolase AYR67_15615 ENOG4105C01 Dihydroxy-acid dehydratase AYR67_15630 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AYR67_15635 ENOG4108DNC Involved in acetate metabolism (By similarity) AYR67_15640 ENOG4107GFK fumarate AYR67_15660 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AYR67_15680 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AYR67_15690 ENOG4105DWV Homoserine O-trans-acetylase AYR67_15775 ENOG4105SG9 biopolymer transport protein, ExbD AYR67_15790 ENOG4105CIY formyltetrahydrofolate deformylase AYR67_15800 ENOG4107RGH Aldehyde dehydrogenase AYR67_15805 ENOG4105KDC 50s ribosomal protein l28 AYR67_15810 ENOG4105W0E 50S ribosomal protein L33 AYR67_15815 ENOG4105CKD glutathione-regulated potassium-efflux system protein AYR67_15835 ENOG4105VFU Rna-binding protein AYR67_15840 ENOG4105C4R Atp-dependent dna helicase AYR67_15855 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AYR67_15865 ENOG4105KVH Transcriptional regulator AYR67_15875 ENOG41069P5 Protein slyX homolog AYR67_15880 ENOG4105C5H ABC transporter AYR67_15885 ENOG4105N14 lysine exporter protein LysE YggA AYR67_15890 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AYR67_15900 ENOG4105CK2 sodium dicarboxylate symporter AYR67_15955 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AYR67_15980 ENOG4105DUM transcriptional regulator, lysR family AYR67_16005 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AYR67_16020 ENOG4108W5M transcriptional regulator AYR67_16035 ENOG4105D29 Helix-turn-helix type 11 domain protein AYR67_16040 ENOG4107XGZ Hydrolase AYR67_16045 ENOG4105EI2 Pseudouridine synthase AYR67_16050 ENOG4105C03 ribonuclease AYR67_16070 ENOG4105CBN LysR family transcriptional regulator AYR67_16075 ENOG4105EMU Dehydrogenase AYR67_16080 ENOG4105CSA Coproporphyrinogen iii oxidase AYR67_16090 ENOG4107QI1 Mate efflux family protein AYR67_16100 ENOG4107T8P acyl-Coa dehydrogenase AYR67_16140 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AYR67_16145 ENOG4105C5X domain protein AYR67_16160 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AYR67_16170 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AYR67_16175 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AYR67_16180 ENOG4108JU5 Magnesium and cobalt efflux protein AYR67_16185 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AYR67_16190 ENOG4108Z7R Chaperone CsaA AYR67_16200 ENOG4108VAU general secretion pathway protein G AYR67_16205 ENOG4105D7Q type ii secretion system AYR67_16210 ENOG4105C25 Primosomal protein n' AYR67_16215 ENOG4105CKD glutathione-regulated potassium-efflux system protein AYR67_16220 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AYR67_16230 ENOG4105DVC DnaJ domain protein AYR67_16235 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) AYR67_16240 ENOG4107QUT magnesium and cobalt transport protein CorA AYR67_16260 ENOG4107QYX exodeoxyribonuclease v alpha AYR67_16265 ENOG4107QKA exodeoxyribonuclease V beta AYR67_16270 ENOG4105DSY exodeoxyribonuclease V, gamma AYR67_16280 ENOG4105CSR polyphosphate kinase 2 AYR67_16290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AYR67_16305 ENOG41061H0 Monooxygenase AYR67_16310 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AYR67_16325 ENOG4105D65 subunit l AYR67_16330 ENOG4108ZE9 Monovalent cation H antiporter subunit C AYR67_16335 ENOG4107R4Z monovalent cation h antiporter subunit d AYR67_16340 ENOG4105SC1 monovalent cation H antiporter subunit E AYR67_16345 ENOG4105W4C monovalent cation H antiporter subunit F AYR67_16350 ENOG4105KJM monovalent cation h antiporter subunit g AYR67_16365 ENOG4105CHV Transcription elongation factor NusA AYR67_16390 ENOG4107EJC Preprotein translocase subunit SecG AYR67_16400 ENOG4107QHF type ii secretion system protein e AYR67_16415 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AYR67_16425 ENOG4105C2N RNA methyltransferase TrmH family group 3 AYR67_16440 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AYR67_16450 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AYR67_16480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AYR67_16485 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AYR67_16550 ENOG4107ZXU DSBA oxidoreductase AYR67_16565 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AYR67_16580 ENOG4105D3Y Na H antiporter AYR67_16585 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AYR67_16635 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AYR67_16640 ENOG4105PM1 preprotein translocase subunit SecE AYR67_16680 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AYR67_16685 ENOG4105TV9 FHA Domain-Containing protein AYR67_16690 ENOG4105GVR general secretion pathway protein D AYR67_16705 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS AYR67_16730 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AYR67_16735 ENOG4108NEV two component transcriptional regulator, LytTR family AYR67_16740 ENOG4108HRK Histidine kinase AYR67_16755 ENOG4108UTW Plays a role in the regulation of phosphate uptake AYR67_16760 ENOG4105DFG type I secretion outer membrane protein AYR67_16765 ENOG4108RNG Permease of the drug metabolite transporter AYR67_16790 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AYR67_16795 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AYR67_16800 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AYR67_16805 ENOG4105CNI cell division protein FtsW AYR67_16820 ENOG4105CE1 Ferrous iron transport protein b AYR67_16830 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AYR67_16835 ENOG4105T95 Thiol disulfide interChange protein AYR67_16840 ENOG4105D6E homoserine dehydrogenase AYR67_16850 ENOG41061WM D-Alanyl-D-Alanine AYR67_16860 ENOG4107TUY Histidine kinase AYR67_16865 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AYR67_16870 ENOG4105CN1 protease AYR67_16875 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AYR67_16880 ENOG4108K5H permease YjgP YjgQ family protein AYR67_16920 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AYR67_16930 ENOG4105BZU Histidine kinase AYR67_16955 ENOG4108R0M Aminoglycoside AYR67_17005 ENOG4108HWY Beta-lactamase AYR67_17015 ENOG4105F6A helicase AYR67_17035 ENOG4105CHH sulfate transporter AYR67_17080 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AYR67_17130 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AYR67_17170 ENOG4108HWY Beta-lactamase AYR67_17180 ENOG4105F6A helicase AYR67_17200 ENOG4105CHH sulfate transporter AYR67_17250 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AYR67_17260 ENOG4105EPF Outer membrane porin AYR67_17265 ENOG4105F0N pyrophosphate phospho-hydrolase AYR67_17280 ENOG4105CEY Amp-dependent synthetase and ligase AYR67_17285 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AYR67_17290 ENOG41079KZ Major Facilitator Superfamily AYR67_17295 ENOG4105EN6 Membrane AYR67_17305 ENOG4105EE5 Membrane protein terC AYR67_17310 ENOG4108URH decarboxylase AYR67_17325 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AYR67_17340 ENOG4105CCT upf0313 protein AYR67_17360 ENOG4105CS1 NAD(P)H quinone oxidoreductase AYR67_17370 ENOG4105C6T cysteine synthase AYR67_17405 ENOG4105Y7M Transcriptional regulator, TetR family AYR67_17440 ENOG4105C79 DNA protecting protein DprA AYR67_17455 ENOG4108IND Tetr family transcriptional regulator AYR67_17460 ENOG4107RTG Major Facilitator superfamily AYR67_17470 ENOG4108V06 Glutathione peroxidase AYR67_17480 ENOG41090VV Protein of unknown function (DUF2846) AYR67_17515 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AYR67_17540 ENOG4105FDK ABC transporter AYR67_17545 ENOG4105FAV ABC, transporter AYR67_17555 ENOG4105EZR dyp-type peroxidase family protein AYR67_17560 ENOG4107R1I NAD-dependent malic enzyme AYR67_17590 ENOG4105EUB pirin domain protein AYR67_17610 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AYR67_17615 ENOG4106MP8 UPF0754 membrane protein AYR67_17620 ENOG4108VBZ doxx family AYR67_17625 ENOG4105DQR SNARE associated Golgi AYR67_17640 ENOG4107QJE Chromosome Partitioning Protein AYR67_17650 ENOG4107PSF BolA-like protein AYR67_17680 ENOG4105CSH Transporter AYR67_17685 ENOG4105E39 Enoyl-CoA hydratase AYR67_17690 ENOG4105E39 Enoyl-CoA hydratase AYR67_17695 ENOG4105C1G acyl-Coa dehydrogenase AYR67_17705 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AYR67_17710 ENOG4105C26 Dehydrogenase AYR67_17720 ENOG4105C85 amino acid AYR67_17725 ENOG4105C85 amino acid AYR67_17730 ENOG4105M4H endoribonuclease L-psp AYR67_17745 ENOG4105EW9 transcriptional regulator AsnC family AYR67_17770 ENOG4105D3G Pseudouridine synthase AYR67_17810 ENOG4108I0Z Aconitate hydratase AYR67_17815 ENOG4105BZN citrate synthase AYR67_17820 ENOG4105CR4 methylisocitrate lyase AYR67_17825 ENOG4105DRR Transcriptional regulator, GntR family AYR67_17830 ENOG4105CGF Aromatic amino acid aminotransferase AYR67_17835 ENOG4105CXG d-lactate dehydrogenase AYR67_17845 ENOG41073TP transcriptional regulator AYR67_17850 ENOG4105DAA L-lactate AYR67_17855 ENOG4107QKV phosphomannomutase AYR67_17860 ENOG4105CMR udp-glucose 4-epimerase AYR67_17870 ENOG4105C6Y Udp-glucose 6-dehydrogenase AYR67_17875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AYR67_17880 ENOG4105D3Q Sugar transferase AYR67_17885 ENOG4107UKG Glycosyl transferase, family 4 AYR67_17900 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AYR67_17935 ENOG4105F0R Cytidylyltransferase AYR67_17940 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AYR67_17950 ENOG4105D7W serine acetyltransferase AYR67_17955 ENOG4105D2T synthase AYR67_17960 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase AYR67_17965 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AYR67_17975 ENOG4107QQG Dehydrogenase AYR67_17980 ENOG4105DAY polysaccharide export protein AYR67_17990 ENOG4105D75 Capsular exopolysaccharide family AYR67_17995 ENOG4108V1T peptidylprolyl cis-trans isomerase AYR67_18000 ENOG4108V1T peptidylprolyl cis-trans isomerase AYR67_18005 ENOG4105CJR Integral membrane protein (MviN AYR67_18010 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AYR67_18015 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AYR67_18050 ENOG41062JF Transcriptional regulator AYR67_18065 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AYR67_18070 ENOG4105UBK short-chain dehydrogenase reductase AYR67_18085 ENOG4107QZM n-acetylglutamate synthase AYR67_18090 ENOG4105GVF (ABC) transporter AYR67_18095 ENOG4105GVF (ABC) transporter AYR67_18100 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AYR67_18105 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AYR67_18110 ENOG4108VM9 ABC, transporter AYR67_18115 ENOG4108R86 Transcriptional regulator AYR67_18120 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AYR67_18130 ENOG4105DTN riboflavin biosynthesis protein ribF AYR67_18135 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AYR67_18145 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AYR67_18185 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AYR67_18245 ENOG4105CVE Lytic murein transglycosylase AYR67_18250 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AYR67_18255 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AYR67_18270 ENOG4105DFU Cell wall formation (By similarity) AYR67_18280 ENOG4105D5G Transposase AYR67_18285 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AYR67_18290 ENOG4105DU1 integral membrane protein, terc AYR67_18300 ENOG4106032 Glutathionylspermidine synthase AYR67_18310 ENOG4107QUY Guanine deaminase AYR67_18320 ENOG4108UGV hypoxanthine phosphoribosyltransferase AYR67_18330 ENOG4105T95 Thiol disulfide interChange protein AYR67_18335 ENOG4105PGM cation diffusion facilitator family transporter AYR67_18350 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AYR67_18365 ENOG4105VG0 50S ribosomal protein l34