locus-tag class description AXA63_00010 ENOG4107ZXU DSBA oxidoreductase AXA63_00075 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AXA63_00080 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AXA63_00110 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AXA63_00120 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AXA63_00135 ENOG4105C2N RNA methyltransferase TrmH family group 3 AXA63_00145 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AXA63_00160 ENOG4107QHF type ii secretion system protein e AXA63_00170 ENOG4107EJC Preprotein translocase subunit SecG AXA63_00195 ENOG4105CHV Transcription elongation factor NusA AXA63_00210 ENOG4105KJM monovalent cation h antiporter subunit g AXA63_00215 ENOG4105W4C monovalent cation H antiporter subunit F AXA63_00220 ENOG4105SC1 monovalent cation H antiporter subunit E AXA63_00225 ENOG4107R4Z monovalent cation h antiporter subunit d AXA63_00230 ENOG4108ZE9 Monovalent cation H antiporter subunit C AXA63_00235 ENOG4105D65 subunit l AXA63_00250 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AXA63_00255 ENOG41061H0 Monooxygenase AXA63_00270 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AXA63_00280 ENOG4105CSR polyphosphate kinase 2 AXA63_00290 ENOG4105DSY exodeoxyribonuclease V, gamma AXA63_00295 ENOG4107QKA exodeoxyribonuclease V beta AXA63_00300 ENOG4107QYX exodeoxyribonuclease v alpha AXA63_00320 ENOG4107QUT magnesium and cobalt transport protein CorA AXA63_00325 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) AXA63_00330 ENOG4105DVC DnaJ domain protein AXA63_00340 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AXA63_00345 ENOG4105CKD glutathione-regulated potassium-efflux system protein AXA63_00350 ENOG4105C25 Primosomal protein n' AXA63_00355 ENOG4105D7Q type ii secretion system AXA63_00360 ENOG4108VAU general secretion pathway protein G AXA63_00370 ENOG4108Z7R Chaperone CsaA AXA63_00375 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AXA63_00380 ENOG4108JU5 Magnesium and cobalt efflux protein AXA63_00385 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AXA63_00390 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AXA63_00400 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AXA63_00415 ENOG4105C5X domain protein AXA63_00420 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AXA63_00465 ENOG4107T8P acyl-Coa dehydrogenase AXA63_00475 ENOG4107QI1 Mate efflux family protein AXA63_00485 ENOG4105CSA Coproporphyrinogen iii oxidase AXA63_00490 ENOG4105EMU Dehydrogenase AXA63_00495 ENOG4105CBN LysR family transcriptional regulator AXA63_00515 ENOG4105C03 ribonuclease AXA63_00520 ENOG4105EI2 Pseudouridine synthase AXA63_00525 ENOG4107XGZ Hydrolase AXA63_00530 ENOG4105D29 Helix-turn-helix type 11 domain protein AXA63_00545 ENOG4108W5M transcriptional regulator AXA63_00560 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AXA63_00585 ENOG4105DUM transcriptional regulator, lysR family AXA63_00610 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AXA63_00665 ENOG4105CK2 sodium dicarboxylate symporter AXA63_00675 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AXA63_00680 ENOG4105N14 lysine exporter protein LysE YggA AXA63_00685 ENOG4105C5H ABC transporter AXA63_00690 ENOG41069P5 Protein slyX homolog AXA63_00700 ENOG4105KVH Transcriptional regulator AXA63_00710 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AXA63_00725 ENOG4105C4R Atp-dependent dna helicase AXA63_00730 ENOG4105VFU Rna-binding protein AXA63_00750 ENOG4105CKD glutathione-regulated potassium-efflux system protein AXA63_00755 ENOG4105W0E 50S ribosomal protein L33 AXA63_00760 ENOG4105KDC 50s ribosomal protein l28 AXA63_00765 ENOG4107RGH Aldehyde dehydrogenase AXA63_00775 ENOG4105CIY formyltetrahydrofolate deformylase AXA63_00875 ENOG4105DWV Homoserine O-trans-acetylase AXA63_00885 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AXA63_00895 ENOG4108ESX Receptor AXA63_00905 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AXA63_00925 ENOG4107GFK fumarate AXA63_00930 ENOG4108DNC Involved in acetate metabolism (By similarity) AXA63_00935 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AXA63_00940 ENOG4105C01 Dihydroxy-acid dehydratase AXA63_00945 ENOG4108UHU Aldolase AXA63_00950 ENOG4105C6Z Gluconate AXA63_00955 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AXA63_00960 ENOG4105C26 Dehydrogenase AXA63_00970 ENOG4106HB6 Alpha beta hydrolase AXA63_00985 ENOG4105CN1 protease AXA63_01000 ENOG4105WVQ Fe-S assembly protein IscX AXA63_01020 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) AXA63_01040 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AXA63_01060 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AXA63_01075 ENOG4105CEY Amp-dependent synthetase and ligase AXA63_01090 ENOG4105C84 Histidine ammonia-lyase AXA63_01120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AXA63_01130 ENOG4105C2D reductase AXA63_01135 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AXA63_01155 ENOG4105VW4 glutaredoxin 3 AXA63_01165 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AXA63_01170 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AXA63_01180 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AXA63_01185 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AXA63_01190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AXA63_01195 ENOG4105DJY efflux transporter, rnd family, mfp subunit AXA63_01220 ENOG4105C7K acetolactate synthase AXA63_01225 ENOG4108ZP8 Acetolactate synthase small subunit AXA63_01235 ENOG4105BZU Histidine kinase AXA63_01255 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AXA63_01270 ENOG4105F8V Hydrolase, tatD family AXA63_01275 ENOG4107QM5 aconitate hydratase AXA63_01285 ENOG4105CUZ uba thif-type nad fad binding protein AXA63_01290 ENOG4107RSM transcriptional regulator AXA63_01300 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AXA63_01315 ENOG4106UX7 integral membrane protein AXA63_01320 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AXA63_01325 ENOG4105W8H transhydrogenase (subunit alpha AXA63_01330 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AXA63_01345 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AXA63_01350 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AXA63_01355 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase AXA63_01360 ENOG4105BZU Histidine kinase AXA63_01365 ENOG4105C6T cysteine synthase AXA63_01380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AXA63_01390 ENOG4105DXN mazG family AXA63_01395 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AXA63_01400 ENOG4105DJ0 Poly(A) Polymerase AXA63_01405 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AXA63_01425 ENOG41080Z8 PHOSPHOCARRIER protein AXA63_01430 ENOG4105N42 UPF0307 protein AXA63_01435 ENOG4105CEY Amp-dependent synthetase and ligase AXA63_01450 ENOG4105CYM Glutathione S-transferase AXA63_01455 ENOG4105W39 Membrane AXA63_01470 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AXA63_01495 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AXA63_01510 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AXA63_01520 ENOG4105C9X ppx gppa phosphatase AXA63_01530 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AXA63_01535 ENOG4105II7 pyrroline-5-carboxylate reductase AXA63_01540 ENOG4108VIA integral membrane protein AXA63_01545 ENOG4105C2M dna polymerase I AXA63_01565 ENOG4107QHF type ii secretion system protein e AXA63_01570 ENOG4108ZHJ Organic hydroperoxide resistance protein AXA63_01575 ENOG4105K56 Transcriptional regulator AXA63_01645 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AXA63_01650 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AXA63_01655 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AXA63_01665 ENOG4105CRQ synthase (Component I) AXA63_01710 ENOG4108Z0R Transferase AXA63_01715 ENOG41072GX Peptidase M22 Glycoprotease AXA63_01740 ENOG4105DJV ribulose-phosphate 3-epimerase AXA63_01745 ENOG4108HCJ Hydrolase AXA63_01755 ENOG4105E3B Multicopper oxidase AXA63_01760 ENOG4105VR0 copper resistance AXA63_01775 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AXA63_01780 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AXA63_01785 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AXA63_01820 ENOG4105ETT transcriptional Regulator, LysR family AXA63_01825 ENOG4105C1G acyl-Coa dehydrogenase AXA63_01830 ENOG4107RGD Major Facilitator superfamily AXA63_01835 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AXA63_01845 ENOG4107EFR Flavocytochrome c AXA63_01850 ENOG4106P55 Transcriptional regulator AXA63_01865 ENOG4106P55 Transcriptional regulator AXA63_01875 ENOG4105CH2 amidohydrolase AXA63_01905 ENOG4105NX3 Membrane AXA63_01945 ENOG4105ETT transcriptional Regulator, LysR family AXA63_01955 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AXA63_01960 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) AXA63_01975 ENOG4108HWY Beta-lactamase AXA63_01985 ENOG4105F6A helicase AXA63_01995 ENOG4107QJE Chromosome Partitioning Protein AXA63_02000 ENOG4105ECI YeeC-like protein AXA63_02010 ENOG4105F6A helicase AXA63_02025 ENOG4108HWY Beta-lactamase AXA63_02035 ENOG4105F6A helicase AXA63_02045 ENOG4107QJE Chromosome Partitioning Protein AXA63_02050 ENOG4105ECI YeeC-like protein AXA63_02060 ENOG4105F6A helicase AXA63_02095 ENOG4105JAB phenazine biosynthesis protein, phzf family AXA63_02115 ENOG4105DZG Dehydrogenase AXA63_02185 ENOG4105EB3 Histidine kinase AXA63_02195 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AXA63_02205 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AXA63_02215 ENOG4107EXC regulatoR AXA63_02220 ENOG4105E0F Histidine kinase AXA63_02230 ENOG4105BZU Histidine kinase AXA63_02250 ENOG4105GKE subunit e AXA63_02255 ENOG4107QIZ NADH dehydrogenase AXA63_02260 ENOG4108IEH NADH dehydrogenase subunit g AXA63_02275 ENOG4107UFS subunit j AXA63_02285 ENOG4105D65 subunit l AXA63_02290 ENOG4105C8S subunit m AXA63_02310 ENOG4105DUM transcriptional regulator, lysR family AXA63_02315 ENOG4105DP0 ferredoxin-NADP reductase AXA63_02340 ENOG4105CBX hi0933 family AXA63_02345 ENOG4105K6H D-cysteine desulfhydrase AXA63_02375 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AXA63_02385 ENOG4105D1F ATP-binding protein AXA63_02435 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AXA63_02445 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AXA63_02460 ENOG4105HF0 Membrane AXA63_02470 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AXA63_02490 ENOG4106UW1 Major Facilitator superfamily AXA63_02495 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AXA63_02500 ENOG4108K4C ec 3.1.3.12 AXA63_02505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AXA63_02515 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AXA63_02520 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AXA63_02530 ENOG4105FE9 pseudouridine synthase AXA63_02535 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AXA63_02540 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AXA63_02545 ENOG4107RTD sua5 ycio yrdc ywlc family protein AXA63_02550 ENOG4108BPE -transporting atpase AXA63_02555 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AXA63_02565 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AXA63_02570 ENOG4105CHR reductase AXA63_02580 ENOG4109066 lysm domain bon superfamily protein AXA63_02585 ENOG4105DWF phosphomethylpyrimidine kinase AXA63_02595 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AXA63_02625 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AXA63_02655 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AXA63_02670 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AXA63_02675 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AXA63_02680 ENOG4105C34 Pseudouridine synthase AXA63_02685 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AXA63_02705 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AXA63_02725 ENOG4105EJC lysr family transcriptional regulator AXA63_02730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AXA63_02735 ENOG4105C94 Transporter AXA63_02745 ENOG4105DVW rieske (2Fe-2S) AXA63_02750 ENOG4105C26 Dehydrogenase AXA63_02755 ENOG4105E3J oxidoreductase AXA63_02770 ENOG4105C4K Nad synthetase AXA63_02780 ENOG4105EUB pirin domain protein AXA63_02785 ENOG4108YXA Membrane AXA63_02830 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AXA63_02840 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AXA63_02845 ENOG4105C3M thioredoxin reductase AXA63_02850 ENOG4105CNU cell division protein FtsK AXA63_02880 ENOG4107QMS site-determining protein AXA63_02895 ENOG4106HNH Acyl-transferase AXA63_02900 ENOG4108ZG0 Ompa motb domain protein AXA63_02905 ENOG4105C4R Atp-dependent dna helicase AXA63_02915 ENOG4107QKV phosphomannomutase AXA63_02930 ENOG4105E7A Glutamine amidotransferase AXA63_02955 ENOG41090R7 Ferric uptake AXA63_02960 ENOG4105CZX twitching motility protein AXA63_02965 ENOG4105CZX twitching motility protein AXA63_02970 ENOG4105DFA alanine racemase domain protein AXA63_02975 ENOG4105EYH Exonuclease AXA63_02980 ENOG4107RH8 nuclease SbcCD subunit D AXA63_03000 ENOG4105ECP epimerase AXA63_03005 ENOG4105MWK D-amino acid dehydrogenase, small subunit AXA63_03010 ENOG4105D52 delta-aminolevulinic acid dehydratase AXA63_03015 ENOG4108VUY thioesterase Superfamily protein AXA63_03020 ENOG4105CW7 secretion protein, HlyD family AXA63_03025 ENOG4105C0R drug resistance transporter emrb qaca subfamily AXA63_03030 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AXA63_03055 ENOG41083X2 DNA polymerase III, epsilon subunit AXA63_03210 ENOG4105VTN Protein of unknown function (DUF1311) AXA63_03355 ENOG4105K4U addiction module toxin, RelE StbE family AXA63_03395 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AXA63_03475 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AXA63_03530 ENOG4105C54 Major Facilitator superfamily AXA63_03535 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXA63_03545 ENOG4108SF5 RNA Polymerase AXA63_03575 ENOG4108YNN Heme oxygenase AXA63_03600 ENOG4105D5Q Arginine ornithine antiporter AXA63_03605 ENOG4107QK5 Homocysteine s-methyltransferase AXA63_03630 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AXA63_03635 ENOG4105C94 Transporter AXA63_03640 ENOG4105C94 Transporter AXA63_03660 ENOG4105CKI cobalamin synthesis protein AXA63_03670 ENOG4108VWS Yaeq family AXA63_03680 ENOG4107BJW polysaccharide deacetylase AXA63_03685 ENOG4105CND Glycosyl transferase, family 2 AXA63_03695 ENOG4106YT9 Enoyl-CoA hydratase AXA63_03710 ENOG41069M3 Transcriptional regulator AXA63_03730 ENOG4105CHR reductase AXA63_03740 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase AXA63_03745 ENOG4105DJB Major Facilitator Superfamily AXA63_03755 ENOG4108MXF Alpha Beta Hydrolase AXA63_03760 ENOG4105CHR reductase AXA63_03775 ENOG4105C7K acetolactate synthase AXA63_03785 ENOG4105CSH Transporter AXA63_03790 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AXA63_03795 ENOG4105CSV Glutaminase AXA63_03800 ENOG4108R6W Transcriptional regulator, ARAC family AXA63_03805 ENOG4105EU0 Major facilitator Superfamily AXA63_03810 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AXA63_03820 ENOG4108PZW LysR family Transcriptional regulator AXA63_03830 ENOG4105CSP Major Facilitator Superfamily AXA63_03845 ENOG4105C3R Methionine synthase AXA63_03850 ENOG4105CJ3 phosphate transporter AXA63_03870 ENOG4105E6M Sulphatase-modifying factor protein AXA63_03875 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AXA63_03890 ENOG4107RNH Outer membrane receptor FepA AXA63_03910 ENOG4108UJV acyl-CoA thioesterase i AXA63_03915 ENOG4108I0Y (ABC) transporter AXA63_03920 ENOG4105CV6 ABC transporter, permease AXA63_03925 ENOG4107U91 Rhomboid family AXA63_03945 ENOG4105C5Q Transcriptional regulator AXA63_03955 ENOG4107QZF nitrite reductase NADPH large subunit AXA63_03960 ENOG4105VCQ rubredoxin AXA63_03980 ENOG4108MRJ AXA63_03990 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AXA63_04005 ENOG4105D4T Citrate transporter AXA63_04015 ENOG4105C37 (CBS) domain AXA63_04025 ENOG4107RET Isocitrate lyase AXA63_04065 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AXA63_04080 ENOG4106H78 methyltransferase AXA63_04085 ENOG4105CJN penicillin-binding protein AXA63_04105 ENOG4105CSM endonuclease III AXA63_04110 ENOG4108R3D Electron transport complex AXA63_04115 ENOG4105D82 Glutamate dehydrogenase AXA63_04125 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AXA63_04150 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AXA63_04475 ENOG4105DR5 peptidase AXA63_04520 ENOG4105DIJ Phosphoethanolamine transferase AXA63_04555 ENOG4107RAQ aminopeptidase AXA63_04560 ENOG4105D0A hydroxylase AXA63_04565 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AXA63_04585 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AXA63_04590 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AXA63_04600 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AXA63_04610 ENOG4105W4M Transport-associated protein AXA63_04620 ENOG4105E09 nadh pyrophosphatase AXA63_04630 ENOG4107RZZ dna polymerase iii epsilon subunit AXA63_04635 ENOG4105E9H Lytic Murein transglycosylase AXA63_04635 ENOG4105E9H Lytic Murein transglycosylase AXA63_04645 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AXA63_04650 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AXA63_04655 ENOG4108JQ5 ABC transporter AXA63_04675 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AXA63_04695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXA63_04710 ENOG4108M3P Membrane AXA63_04715 ENOG4105D01 (LipO)protein AXA63_04735 ENOG4105CNA YD repeat protein AXA63_04780 ENOG4105C85 amino acid AXA63_04790 ENOG4105CUB amino acid AXA63_04810 ENOG4105C26 Dehydrogenase AXA63_04830 ENOG4105C85 amino acid AXA63_04890 ENOG4105F95 Monooxygenase AXA63_04900 ENOG4105C7N Xanthine uracil vitamin C permease AXA63_04905 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AXA63_04910 ENOG4105CPW cytochrome b561 AXA63_04920 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AXA63_04930 ENOG4105CFH Aspartokinase AXA63_04940 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AXA63_04950 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AXA63_04965 ENOG4105CPC Aldo Keto reductase AXA63_04980 ENOG4107RYR Transcriptional regulator, Crp Fnr family AXA63_04985 ENOG4108UKZ OsmC family AXA63_05000 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AXA63_05030 ENOG4105CD3 dihydroorotase AXA63_05035 ENOG4108ZG0 Ompa motb domain protein AXA63_05045 ENOG4108TGY Glutathione S-transferase AXA63_05050 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AXA63_05060 ENOG4108K3A Glutathione S-transferase AXA63_05070 ENOG4108JU3 Alkyl hydroperoxide reductase AXA63_05080 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AXA63_05090 ENOG4105D3R alkyl hydroperoxide reductase AXA63_05095 ENOG4105CQ7 ATP-dependent helicase AXA63_05110 ENOG4105D2S major facilitator superfamily AXA63_05115 ENOG4105DKK Benzoate AXA63_05120 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase AXA63_05125 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein AXA63_05130 ENOG4108UKV benzoate 1,2-dioxygenase AXA63_05135 ENOG4105FUY alpha subunit AXA63_05140 ENOG4108KB2 LysR family Transcriptional regulator AXA63_05190 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AXA63_05225 ENOG410829K Lysine exporter protein (Lyse ygga) AXA63_05230 ENOG4105VEQ Cold shock protein AXA63_05240 ENOG4105II7 pyrroline-5-carboxylate reductase AXA63_05265 ENOG4107YPT transcriptional regulator AXA63_05300 ENOG4105C2X Arabinose 5-phosphate isomerase AXA63_05305 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AXA63_05315 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AXA63_05320 ENOG4108IUZ ABC transporter AXA63_05325 ENOG4105DFG type I secretion outer membrane protein AXA63_05365 ENOG4108Z4U Ferredoxin AXA63_05385 ENOG4107AQZ Membrane AXA63_05390 ENOG4105BZU Histidine kinase AXA63_05395 ENOG4105D1S lipid A biosynthesis AXA63_05405 ENOG4105D2S major facilitator superfamily AXA63_05425 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AXA63_05455 ENOG4105CNA YD repeat protein AXA63_05470 ENOG4108WAV Transcriptional regulator AXA63_05475 ENOG4105C5A transporter AXA63_05495 ENOG4108JIK carboxylase AXA63_05500 ENOG4107R4J Chloride channel AXA63_05525 ENOG4105R8C Transcriptional regulator AXA63_05535 ENOG4105E2A Dehydrogenase AXA63_05550 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AXA63_05555 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF AXA63_05560 ENOG4105KVH Transcriptional regulator AXA63_05575 ENOG4105MRR Transcriptional regulator (By similarity) AXA63_05585 ENOG4108HW3 (ABC) transporter AXA63_05615 ENOG4108Z4X TRANSCRIPTIONal AXA63_05625 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXA63_05645 ENOG4105MWK D-amino acid dehydrogenase, small subunit AXA63_05670 ENOG4105CZJ Aldehyde dehydrogenase AXA63_05675 ENOG4107QTZ amino acid AXA63_05680 ENOG4105EJQ L-serine dehydratase AXA63_05685 ENOG4105DXM phenylacetic acid degradation protein AXA63_05690 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AXA63_05695 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AXA63_05700 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AXA63_05705 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AXA63_05710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AXA63_05715 ENOG4105E39 Enoyl-CoA hydratase AXA63_05720 ENOG4108UKI Enoyl-CoA hydratase AXA63_05725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AXA63_05730 ENOG4105CHU acetyl-coa acetyltransferase AXA63_05735 ENOG4105DZS Phenylacetate-CoA ligase AXA63_05740 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AXA63_05750 ENOG4107YAU phenylacetic acid degradation protein AXA63_05785 ENOG4107VGR Catalase AXA63_05790 ENOG4105CPW cytochrome b561 AXA63_05810 ENOG4108MXF Alpha Beta Hydrolase AXA63_05815 ENOG4105MXW flavin reductase domain protein, FMN-binding AXA63_05820 ENOG4108M8W Monooxygenase AXA63_05825 ENOG4105C26 Dehydrogenase AXA63_05830 ENOG4105ETS cytosine purines uracil thiamine allantoin AXA63_05840 ENOG4105C26 Dehydrogenase AXA63_05845 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AXA63_05850 ENOG4105HEI LysR family (Transcriptional regulator AXA63_05860 ENOG4107HP6 Transcriptional regulator AXA63_05865 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AXA63_05875 ENOG4105C4Y ABC transporter AXA63_05880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AXA63_05885 ENOG4107RCV ABC transporter, permease AXA63_05895 ENOG4107STF Involved in phosphonate degradation (By similarity) AXA63_05900 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AXA63_05905 ENOG4107RGD Major Facilitator superfamily AXA63_05910 ENOG4105C1G acyl-Coa dehydrogenase AXA63_05925 ENOG4108UKI Enoyl-CoA hydratase AXA63_05930 ENOG4105EA8 2-Nitropropane dioxygenase AXA63_05935 ENOG4105EQ0 Major Facilitator superfamily AXA63_05945 ENOG4105CHU acetyl-coa acetyltransferase AXA63_05950 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AXA63_05955 ENOG4105CHR reductase AXA63_05960 ENOG4105E39 Enoyl-CoA hydratase AXA63_05965 ENOG4105C1G acyl-Coa dehydrogenase AXA63_05970 ENOG4107RGD Major Facilitator superfamily AXA63_05975 ENOG4107QP7 CoA-transferase subunit A AXA63_05980 ENOG4107QNJ CoA-transferase subunit B AXA63_05990 ENOG4105EQ0 Major Facilitator superfamily AXA63_06000 ENOG4105CSU acyl-Coa dehydrogenase AXA63_06015 ENOG4105CC0 LysR family Transcriptional regulator AXA63_06030 ENOG4105E39 Enoyl-CoA hydratase AXA63_06035 ENOG4107QX3 carboxylase AXA63_06040 ENOG4105C1G acyl-Coa dehydrogenase AXA63_06045 ENOG4105R8C Transcriptional regulator AXA63_06050 ENOG4105CEY Amp-dependent synthetase and ligase AXA63_06070 ENOG4105HEI LysR family (Transcriptional regulator AXA63_06120 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AXA63_06140 ENOG4105KT5 UmuD protein AXA63_06150 ENOG4105EW9 transcriptional regulator AsnC family AXA63_06160 ENOG4105BZU Histidine kinase AXA63_06165 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AXA63_06175 ENOG4105EAD ABC transporter AXA63_06180 ENOG4108HW4 amino acid AbC transporter AXA63_06185 ENOG4105CDA abc transporter atp-binding protein AXA63_06190 ENOG4107RP9 extracellular solute-binding protein, family 3 AXA63_06195 ENOG4105CT1 (ABC) transporter AXA63_06200 ENOG4105EXG Transcriptional regulator AXA63_06210 ENOG4105C9B Cysteine desulfurase AXA63_06215 ENOG4105ESN nucleotide-binding protein AXA63_06220 ENOG4105D7W serine acetyltransferase AXA63_06230 ENOG4105CHR reductase AXA63_06235 ENOG4105CBN LysR family transcriptional regulator AXA63_06240 ENOG4105CYM Glutathione S-transferase AXA63_06245 ENOG4108SHQ Glutathione S-transferase AXA63_06250 ENOG4105CMU LysR family (Transcriptional regulator AXA63_06255 ENOG4105VAW lrga family AXA63_06260 ENOG41067MG lrgb family AXA63_06280 ENOG4105DXI Major Facilitator superfamily AXA63_06290 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AXA63_06295 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) AXA63_06310 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase AXA63_06315 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AXA63_06330 ENOG4108K70 Transcriptional regulator AXA63_06335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXA63_06345 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AXA63_06350 ENOG4105C4M (Ubiquinol oxidase) subunit I AXA63_06370 ENOG4105C54 Major Facilitator superfamily AXA63_06380 ENOG4106FTQ Taurine ABC transporter, periplasmic AXA63_06385 ENOG4108IY8 ABC, transporter AXA63_06390 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AXA63_06395 ENOG4105E2B Taurine dioxygenase AXA63_06405 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AXA63_06415 ENOG4105CBN LysR family transcriptional regulator AXA63_06425 ENOG4105CPN adenine deaminase AXA63_06440 ENOG41082YX Transcriptional regulator, arsr family AXA63_06445 ENOG4105D6J arsenicaL-resistance protein AXA63_06450 ENOG4108KB2 LysR family Transcriptional regulator AXA63_06465 ENOG4108JU3 Alkyl hydroperoxide reductase AXA63_06490 ENOG4105C0B DNA polymerase III (alpha subunit) AXA63_06505 ENOG4105CHM Aminotransferase AXA63_06515 ENOG4108V06 Glutathione peroxidase AXA63_06520 ENOG4105E7U AraC family transcriptional regulator AXA63_06550 ENOG4105ZED uncharacterized protein ygaH AXA63_06555 ENOG4108UMN azlc family AXA63_06580 ENOG4105C3G gtp-binding protein AXA63_06585 ENOG4108UMI ABC transporter, permease AXA63_06590 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXA63_06595 ENOG4105D01 (LipO)protein AXA63_06600 ENOG4105D01 (LipO)protein AXA63_06615 ENOG4107T8P acyl-Coa dehydrogenase AXA63_06630 ENOG4105EAD ABC transporter AXA63_06635 ENOG4105DRP amino acid AbC transporter AXA63_06640 ENOG4105CDA abc transporter atp-binding protein AXA63_06650 ENOG4105EW9 transcriptional regulator AsnC family AXA63_06675 ENOG41067SE Tetr family transcriptional regulator AXA63_06705 ENOG4105CC0 LysR family Transcriptional regulator AXA63_06715 ENOG4105ETS cytosine purines uracil thiamine allantoin AXA63_06725 ENOG4108IPJ Membrane AXA63_06750 ENOG4105GQR Chaperone AXA63_06755 ENOG4105X0I Fimbrial AXA63_06775 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AXA63_06780 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AXA63_06800 ENOG4108HWY Beta-lactamase AXA63_06825 ENOG4105CV1 Transketolase (EC 2.2.1.1) AXA63_06835 ENOG4108YYC ycei family AXA63_06845 ENOG4108T58 Mg2 transport protein CorA AXA63_06860 ENOG4105YGK Pfam:UPF0157 AXA63_06865 ENOG4105C26 Dehydrogenase AXA63_06870 ENOG4105EW9 transcriptional regulator AsnC family AXA63_06875 ENOG4105CK7 Sodium proline symporter AXA63_06880 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AXA63_06890 ENOG4108ZX5 transcriptional regulator AXA63_06900 ENOG4105BZ1 (ABC) transporter AXA63_06905 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AXA63_06910 ENOG4105XPP Protein of unknown function (DUF1275) AXA63_06920 ENOG41080HT Transcriptional regulator, arsr family AXA63_06930 ENOG4105EZE Cupin 4 family protein AXA63_06935 ENOG4108UHJ MAF-like protein AXA63_06955 ENOG4105D2N Aldolase AXA63_06960 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AXA63_06965 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AXA63_06970 ENOG4105EHM Aminoglycoside phosphotransferase AXA63_06975 ENOG4108S0S Nucleotidyl transferase AXA63_06985 ENOG4107QJE Chromosome Partitioning Protein AXA63_06990 ENOG4105FA0 parb-like partition protein AXA63_07005 ENOG4105BZ1 (ABC) transporter AXA63_07010 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AXA63_07020 ENOG4107QRG dna polymerase iii AXA63_07030 ENOG4105F8V Hydrolase, tatD family AXA63_07055 ENOG4108RTD type II secretion system protein K AXA63_07075 ENOG4108Z6B deaminase AXA63_07090 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AXA63_07095 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AXA63_07115 ENOG4107RN6 Monooxygenase AXA63_07125 ENOG4105D6Z AFG1 family ATPase AXA63_07130 ENOG4107QP3 malate synthase g AXA63_07140 ENOG4105SG9 biopolymer transport protein, ExbD AXA63_07175 ENOG4105DGW oligopeptidase A AXA63_07185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AXA63_07220 ENOG4105K4T epimerase AXA63_07225 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AXA63_07245 ENOG4108JA2 transcriptioN-repair coupling factor AXA63_07255 ENOG4105F8J Adenylate Guanylate cyclase AXA63_07260 ENOG4108ZIT Ferredoxin, 2FE-2S AXA63_07275 ENOG4108Z4V iron-sulfur cluster assembly AXA63_07280 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AXA63_07290 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AXA63_07305 ENOG4105K70 DNA-binding protein AXA63_07310 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AXA63_07315 ENOG4105E7U AraC family transcriptional regulator AXA63_07320 ENOG4105EEF Alkane 1-monooxygenase AXA63_07325 ENOG4105C1G acyl-Coa dehydrogenase AXA63_07330 ENOG4105C1G acyl-Coa dehydrogenase AXA63_07345 ENOG4108Z66 YbaK ebsC protein AXA63_07365 ENOG4105DUU IucA IucC family protein AXA63_07370 ENOG4105DJU Siderophore biosynthesis protein AXA63_07410 ENOG4107VXZ Hydrolase AXA63_07420 ENOG4108YZT Adenosylcobinamide kinase AXA63_07425 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AXA63_07445 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AXA63_07450 ENOG4107TSN permease AXA63_07470 ENOG4105CNM Receptor AXA63_07475 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AXA63_07490 ENOG4105CJ1 ABC, transporter AXA63_07495 ENOG4107QWP ABC-2 type transporter AXA63_07500 ENOG4107QWP ABC-2 type transporter AXA63_07525 ENOG4105K59 histidine triad (HIT) protein AXA63_07555 ENOG4105F2W methyltransferase AXA63_07565 ENOG4105C28 cystathionine AXA63_07590 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AXA63_07635 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AXA63_07640 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AXA63_07650 ENOG4105BZU Histidine kinase AXA63_07665 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AXA63_07670 ENOG4107R0V Pyruvate dehydrogenase AXA63_07675 ENOG4105CPP Dehydrogenase, E1 component AXA63_07690 ENOG4105CHR reductase AXA63_07700 ENOG4105FFC UPF0187 protein AXA63_07710 ENOG4107QPB Beta-lactamase domain protein AXA63_07720 ENOG4108VCT Sulfite exporter TauE/SafE AXA63_07735 ENOG4105UEI Transcriptional Regulator AraC Family AXA63_07740 ENOG4105KVH Transcriptional regulator AXA63_07745 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AXA63_07755 ENOG4105FDP GntR family transcriptional regulator AXA63_07770 ENOG4106FTQ Taurine ABC transporter, periplasmic AXA63_07775 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AXA63_07795 ENOG4105CSH Transporter AXA63_07805 ENOG4108IJ0 Aspartate ammonia-lyase AXA63_07820 ENOG4107YNJ LysR family Transcriptional regulator AXA63_07830 ENOG4105CHU acetyl-coa acetyltransferase AXA63_07835 ENOG4105CRW Short chain fatty acid transporter AXA63_07840 ENOG4107QNJ CoA-transferase subunit B AXA63_07850 ENOG4108M0I Transcriptional regulator AXA63_07860 ENOG4105CY2 Citrate transporter AXA63_07865 ENOG4105DTD Dehydrogenase AXA63_07880 ENOG4105CF7 AraC family transcriptional regulator AXA63_07885 ENOG4105D2S major facilitator superfamily AXA63_07895 ENOG4105CHR reductase AXA63_07920 ENOG4105F57 Anthranilate dioxygenase reductase AXA63_07925 ENOG4108YS2 small subunit AXA63_07930 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit AXA63_07935 ENOG4105F4R Transcriptional regulator mode AXA63_07940 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AXA63_07945 ENOG4105E0C molybdate abc transporter AXA63_07950 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AXA63_07955 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AXA63_07960 ENOG4105WQI isochorismatase AXA63_07970 ENOG4107T31 5'-nucleotidase AXA63_08000 ENOG4108IGT Dipeptidase AXA63_08020 ENOG4107RZC phospholipase d AXA63_08080 ENOG4105X0I Fimbrial AXA63_08105 ENOG4105CJP fad dependent oxidoreductase AXA63_08125 ENOG4105CT3 Monooxygenase AXA63_08135 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AXA63_08140 ENOG4105BZS acriflavin resistance protein AXA63_08145 ENOG4105C1P efflux transporter, rnd family, mfp subunit AXA63_08150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXA63_08155 ENOG4105E0F Histidine kinase AXA63_08160 ENOG4108821 RND type efflux pump AXA63_08165 ENOG4108R6W Transcriptional regulator, ARAC family AXA63_08180 ENOG4108BAS reductase AXA63_08235 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AXA63_08275 ENOG4108UAJ Transcriptional regulator AXA63_08355 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AXA63_08375 ENOG4105E0A ABC, transporter AXA63_08380 ENOG4105EHG Permease protein AXA63_08390 ENOG4105DQ4 alcohol dehydrogenase AXA63_08405 ENOG4105CF7 AraC family transcriptional regulator AXA63_08410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AXA63_08420 ENOG4105EXW epimerase dehydratase AXA63_08425 ENOG4105DDW LysR family Transcriptional regulator AXA63_08435 ENOG4105C01 Dihydroxy-acid dehydratase AXA63_08440 ENOG4105CZJ Aldehyde dehydrogenase AXA63_08455 ENOG4105CW7 secretion protein, HlyD family AXA63_08475 ENOG4105JSC dimethylmenaquinone methyltransferase AXA63_08480 ENOG4108JQ1 Dehydrogenase AXA63_08505 ENOG4106KR7 LysR family Transcriptional regulator AXA63_08520 ENOG4105FDP GntR family transcriptional regulator AXA63_08550 ENOG4105CKT filamentous hemagglutinin AXA63_08555 ENOG4105D5K Hemolysin activator protein AXA63_08575 ENOG4105CH2 amidohydrolase AXA63_08585 ENOG4105CKD glutathione-regulated potassium-efflux system protein AXA63_08590 ENOG4105D8V Glucose sorbosone dehydrogenase AXA63_08595 ENOG4105EJC lysr family transcriptional regulator AXA63_08600 ENOG4105CHJ isochorismatase hydrolase AXA63_08610 ENOG4107Z3H Transcriptional regulator, TetR family AXA63_08640 ENOG4105NAE bifunctional deaminase-reductase domain protein AXA63_08650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXA63_08655 ENOG4105K56 Transcriptional regulator AXA63_08690 ENOG4105CH6 catalase AXA63_08705 ENOG4107RGH Aldehyde dehydrogenase AXA63_08720 ENOG41062QD Membrane AXA63_08730 ENOG4108JU7 Transcriptional regulator AXA63_08735 ENOG4105CHR reductase AXA63_08740 ENOG4105C1G acyl-Coa dehydrogenase AXA63_08760 ENOG4105CZJ Aldehyde dehydrogenase AXA63_08780 ENOG4107EJG GntR family transcriptional regulator AXA63_08790 ENOG4108KB2 LysR family Transcriptional regulator AXA63_08795 ENOG4105DTQ mandelate racemase muconate lactonizing AXA63_08800 ENOG4105NN7 muconolactone delta-isomerase AXA63_08810 ENOG4107QP7 CoA-transferase subunit A AXA63_08815 ENOG4107QNJ CoA-transferase subunit B AXA63_08820 ENOG4105CHU acetyl-coa acetyltransferase AXA63_08825 ENOG4105F2Z 3-oxoadipate enol-lactonase AXA63_08835 ENOG4105C26 Dehydrogenase AXA63_08845 ENOG4105F11 amine oxidase AXA63_08865 ENOG4105CHR reductase AXA63_08875 ENOG4105FUY alpha subunit AXA63_08895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AXA63_08905 ENOG4105DNH Major Facilitator AXA63_08930 ENOG4105C1G acyl-Coa dehydrogenase AXA63_08935 ENOG4108PTX LysR family Transcriptional regulator AXA63_08940 ENOG4107HP6 Transcriptional regulator AXA63_08955 ENOG4105MD1 YeeE YedE family protein AXA63_08965 ENOG4105DZG Dehydrogenase AXA63_08970 ENOG4105TW1 Carbohydrate-selective porin OprB AXA63_08975 ENOG4106JPM 3-dehydroshikimate dehydratase AXA63_08980 ENOG4105FF2 Type I DHQase AXA63_08985 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha AXA63_08990 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta AXA63_08995 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AXA63_09000 ENOG4105D2S major facilitator superfamily AXA63_09005 ENOG4105F2Z 3-oxoadipate enol-lactonase AXA63_09010 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AXA63_09015 ENOG4105CHU acetyl-coa acetyltransferase AXA63_09020 ENOG4107QNJ CoA-transferase subunit B AXA63_09025 ENOG4107QP7 CoA-transferase subunit A AXA63_09035 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AXA63_09040 ENOG4107VMU Membrane AXA63_09085 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXA63_09100 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AXA63_09110 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AXA63_09115 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AXA63_09145 ENOG4105C7B Threonine dehydratase AXA63_09155 ENOG4105CZN Potassium uptake protein AXA63_09160 ENOG4105HDD phospholipase AXA63_09170 ENOG4105E0K tonB-dependent siderophore receptor AXA63_09185 ENOG4105PV3 Inner membrane protein yqiJ AXA63_09205 ENOG4105C4M (Ubiquinol oxidase) subunit I AXA63_09210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AXA63_09230 ENOG41068P6 UPF0319 protein AXA63_09240 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AXA63_09265 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AXA63_09270 ENOG4105C8Y Acetylornithine aminotransferase AXA63_09275 ENOG4105M2J Glutaredoxin AXA63_09285 ENOG4105CC0 LysR family Transcriptional regulator AXA63_09290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AXA63_09295 ENOG4105CWM branched-chain amino acid transport system II carrier protein AXA63_09320 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AXA63_09325 ENOG4105DE4 1-phosphofructokinase AXA63_09330 ENOG4105DM4 PTS System AXA63_09350 ENOG4105BZU Histidine kinase AXA63_09370 ENOG4105D8V Glucose sorbosone dehydrogenase AXA63_09375 ENOG4108RAV Conserved protein AXA63_09380 ENOG4105CHH sulfate transporter AXA63_09395 ENOG4105C85 amino acid AXA63_09405 ENOG4105F7P transcriptional regulator AsnC family AXA63_09430 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AXA63_09435 ENOG4105VEJ Heat shock protein AXA63_09445 ENOG4105Y3E Modulates RecA activity (By similarity) AXA63_09460 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AXA63_09485 ENOG4105DZP Membrane-associated zinc metalloprotease AXA63_09495 ENOG4105KNE Phosphatidate cytidylyltransferase AXA63_09500 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AXA63_09520 ENOG4105CUX Signal transduction histidine kinase AXA63_09525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AXA63_09580 ENOG4105CMR udp-glucose 4-epimerase AXA63_09585 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AXA63_09605 ENOG4105T38 integral membrane protein AXA63_09610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXA63_09620 ENOG4105CVM Molybdenum cofactor synthesis domain protein AXA63_09625 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AXA63_09640 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AXA63_09660 ENOG4108IFG nitrite reductase, (NAD(P)H) AXA63_09665 ENOG4107QZF nitrite reductase NADPH large subunit AXA63_09675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXA63_09695 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AXA63_09700 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AXA63_09710 ENOG4105D8G Major Facilitator superfamily AXA63_09780 ENOG4105DR5 peptidase AXA63_10060 ENOG4105CBC glutamate synthase AXA63_10090 ENOG4105C0A alcohol dehydrogenase AXA63_10100 ENOG4105HSS phospholipase C AXA63_10105 ENOG4107QMP dna polymerase iii subunits gamma and tau AXA63_10130 ENOG4105CHR reductase AXA63_10135 ENOG4105CHU acetyl-coa acetyltransferase AXA63_10145 ENOG4105C5Q Transcriptional regulator AXA63_10150 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AXA63_10155 ENOG4108NIW Leucine export protein LeuE AXA63_10160 ENOG4105EW9 transcriptional regulator AsnC family AXA63_10165 ENOG4105DKK Benzoate AXA63_10175 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AXA63_10195 ENOG41081QV Universal stress protein AXA63_10200 ENOG4105C5H ABC transporter AXA63_10220 ENOG4105CNM Receptor AXA63_10260 ENOG4105CUY Mechanosensitive ion channel AXA63_10270 ENOG4105R8C Transcriptional regulator AXA63_10280 ENOG4105EW9 transcriptional regulator AsnC family AXA63_10285 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) AXA63_10295 ENOG4105EMU Dehydrogenase AXA63_10305 ENOG4105CD8 aminopeptidase N AXA63_10325 ENOG4105F4I Transcriptional regulator AXA63_10335 ENOG4107QUV Domain protein AXA63_10340 ENOG4105C0A alcohol dehydrogenase AXA63_10350 ENOG4107RR1 TRANSCRIPTIONal AXA63_10360 ENOG4107R55 ethanolamine transporter AXA63_10365 ENOG4105CPD ethanolamine ammonia-lyase AXA63_10370 ENOG4107FQ9 ethanolamine ammonia-lyase AXA63_10375 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AXA63_10390 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AXA63_10400 ENOG4108RCM Nitroreductase AXA63_10405 ENOG4108TZV Membrane AXA63_10410 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AXA63_10420 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AXA63_10425 ENOG4105K8N protein family UPF0079, ATPase AXA63_10460 ENOG4105DZ2 Transcriptional regulator AXA63_10495 ENOG4105K70 DNA-binding protein AXA63_10580 ENOG4105CF2 Mu-like prophage FluMu protein GP28 AXA63_10595 ENOG4105QIB mu-like prophage Flumu protein gp29 AXA63_10600 ENOG4108QUU Morphogenesis Protein AXA63_10605 ENOG4107XYH virion morphogenesis protein AXA63_10620 ENOG4105EFV Major head subunit AXA63_10715 ENOG4105F27 Major Facilitator AXA63_10720 ENOG4105EYW Ion transport protein AXA63_10730 ENOG4107QIJ Aconitate hydratase 2 AXA63_10745 ENOG4105CFU surface antigen AXA63_10750 ENOG4107S74 Lysophospholipid transporter LplT AXA63_10765 ENOG4105CFQ glutamine synthetase AXA63_10770 ENOG4105EEX Two component transcriptional regulator (Winged helix family AXA63_10775 ENOG4105C08 Histidine kinase AXA63_10785 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AXA63_10790 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AXA63_10810 ENOG4105D06 uba thif-type nad fad binding protein AXA63_10815 ENOG4108MEJ flavin reductase domain protein AXA63_10825 ENOG4105C1G acyl-Coa dehydrogenase AXA63_10840 ENOG4105GVF (ABC) transporter AXA63_10845 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AXA63_10850 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AXA63_10865 ENOG4105CC0 LysR family Transcriptional regulator AXA63_10880 ENOG4105DEN Luciferase family AXA63_10895 ENOG4105CND Glycosyl transferase, family 2 AXA63_10900 ENOG4107BJW polysaccharide deacetylase AXA63_10925 ENOG4105E2S oxidase) subunit II AXA63_10930 ENOG4105BZ9 Cytochrome C oxidase, subunit I AXA63_10935 ENOG4105CCU oxidase (Subunit III) AXA63_10940 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AXA63_10965 ENOG4105CDU Replicative dna helicase AXA63_10970 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AXA63_11020 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AXA63_11025 ENOG4105DC1 bifunctional purine biosynthesis protein purh AXA63_11030 ENOG4105C12 Phosphoribosylglycinamide synthetase AXA63_11040 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AXA63_11045 ENOG4108UMI ABC transporter, permease AXA63_11050 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AXA63_11235 ENOG4105DY2 Paraquat-inducible protein b AXA63_11240 ENOG4105F1S paraquat-inducible protein a AXA63_11255 ENOG4105CEB Aspartate aminotransferase AXA63_11275 ENOG4105CSH Transporter AXA63_11340 ENOG4105JXH GntR family transcriptional regulator AXA63_11350 ENOG4105D6U Sodium Glutamate Symporter AXA63_11380 ENOG4105H4F exported protein AXA63_11415 ENOG4105C26 Dehydrogenase AXA63_11420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AXA63_11425 ENOG4105EVZ LysR family transcriptional regulator AXA63_11450 ENOG4105D9P serine threonine protein kinase AXA63_11475 ENOG4105VCC 30S ribosomal protein S21 AXA63_11480 ENOG4105KTH gatB Yqey AXA63_11485 ENOG4105ERG peptidase m48, ste24p AXA63_11490 ENOG4105C5I Dehydrogenase AXA63_11505 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AXA63_11540 ENOG41069NU Nitroreductase AXA63_11550 ENOG4105C1J atp-dependent rna helicase AXA63_11555 ENOG4105VEQ Cold shock protein AXA63_11565 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXA63_11570 ENOG4105M08 Membrane AXA63_11600 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AXA63_11605 ENOG4105CIN aminoacyl-histidine dipeptidase AXA63_11615 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AXA63_11620 ENOG4105CQC Prephenate dehydratase AXA63_11625 ENOG4105NIV Esterase AXA63_11630 ENOG4105C1G acyl-Coa dehydrogenase AXA63_11635 ENOG4105CK2 sodium dicarboxylate symporter AXA63_11640 ENOG4107QYG anthranilate phosphoribosyltransferase AXA63_11645 ENOG4105VUT cytoplasmic protein AXA63_11650 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AXA63_11655 ENOG4105BZ4 penicillin-binding protein AXA63_11665 ENOG4105M6F mutator MutT protein AXA63_11675 ENOG4105DHQ Histidine kinase AXA63_11680 ENOG4105XJC Two component transcriptional regulator (Winged helix family AXA63_11690 ENOG4107QHF type ii secretion system protein e AXA63_11700 ENOG4108R96 Methyltransferase, YaeB family AXA63_11705 ENOG4105DP0 ferredoxin-NADP reductase AXA63_11710 ENOG4105JAB phenazine biosynthesis protein, phzf family AXA63_11715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXA63_11720 ENOG4105CFP Peptidase U32 AXA63_11725 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AXA63_11735 ENOG4108JEH abc transporter atp-binding protein AXA63_11740 ENOG4106YG3 ABC transporter AXA63_11745 ENOG4105DSP amino acid AbC transporter AXA63_11750 ENOG4105E89 ABC transporter AXA63_11760 ENOG4105ENT Efflux transporter rnd family, mfp subunit AXA63_11770 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AXA63_11805 ENOG4105DA5 (ABC) transporter AXA63_11810 ENOG4105E3A (ABC) transporter AXA63_11825 ENOG4105CNI cell division protein FtsW AXA63_11830 ENOG4105CVE Lytic murein transglycosylase AXA63_11870 ENOG4105CE9 30S ribosomal protein S2 AXA63_11875 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AXA63_11885 ENOG4107RNU major facilitator superfamily MFS_1 AXA63_11900 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AXA63_11905 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AXA63_11910 ENOG4107QPN acyl-Coa dehydrogenase AXA63_11925 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AXA63_11930 ENOG4105SYT Methylenetetrahydrofolate reductase AXA63_11935 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AXA63_11940 ENOG4105BZU Histidine kinase AXA63_11945 ENOG4105C6K Malic enzyme AXA63_11955 ENOG4105C0H protease AXA63_11960 ENOG4107QNR UPF0135 protein AXA63_11965 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXA63_12000 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AXA63_12010 ENOG4105C5F glutamine synthetase AXA63_12015 ENOG4105DUX Transporter AXA63_12025 ENOG4105DFP Integrase AXA63_12315 ENOG41067QW Transcriptional regulator AXA63_12380 ENOG4105DDQ anthranilate synthase AXA63_12385 ENOG4105CD8 aminopeptidase N AXA63_12415 ENOG4105C7W Xanthine dehydrogenase AXA63_12425 ENOG4105EUJ GTP cyclohydrolase i AXA63_12455 ENOG4105NX3 Membrane AXA63_12480 ENOG4105E4F Isochorismate synthase AXA63_12500 ENOG4105BZ1 (ABC) transporter AXA63_12515 ENOG4105WQI isochorismatase AXA63_12520 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AXA63_12525 ENOG4105C0W non-ribosomal peptide synthetase AXA63_12545 ENOG4108IPW abc transporter atp-binding protein AXA63_12560 ENOG4105CEY Amp-dependent synthetase and ligase AXA63_12575 ENOG4105WWK YheO domain protein AXA63_12585 ENOG4105C2I pirin domain protein AXA63_12600 ENOG4105J7D transcriptional regulator AXA63_12610 ENOG4107WEA mandelate racemase muconate lactonizing AXA63_12615 ENOG4107QNK )-transporter AXA63_12620 ENOG41060M8 Pfam:PhdYeFM AXA63_12650 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AXA63_12655 ENOG4107QZF nitrite reductase NADPH large subunit AXA63_12660 ENOG4105C26 Dehydrogenase AXA63_12670 ENOG4105C94 Transporter AXA63_12675 ENOG4105C94 Transporter AXA63_12685 ENOG4105ETT transcriptional Regulator, LysR family AXA63_12690 ENOG4105C85 amino acid AXA63_12695 ENOG4105C26 Dehydrogenase AXA63_12710 ENOG4108K8K Transcriptional regulator AXA63_12740 ENOG4105VCD cytoplasmic protein AXA63_12745 ENOG4105D22 carbon starvation protein AXA63_12755 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AXA63_12775 ENOG4105DHU Bile acid AXA63_12790 ENOG4105DAN ATP-dependent protease AXA63_12795 ENOG4105EJC lysr family transcriptional regulator AXA63_12800 ENOG4108K5P (LipO)protein AXA63_12820 ENOG4105DZ1 carboxypeptidase AXA63_12825 ENOG4108Z0R Transferase AXA63_12845 ENOG4107QTF adenylosuccinate lyase AXA63_12860 ENOG4105ERU peptidase AXA63_12865 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AXA63_12875 ENOG4105C8U phosphate abc transporter AXA63_12880 ENOG4105CVA phosphate AXA63_12885 ENOG4105C85 amino acid AXA63_12890 ENOG4107RA9 decarboxylase AXA63_12895 ENOG4105F7P transcriptional regulator AsnC family AXA63_12905 ENOG4105DY8 decarboxylase AXA63_12910 ENOG4108JPW Aminotransferase AXA63_12935 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AXA63_12950 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AXA63_12955 ENOG4105D3G Pseudouridine synthase AXA63_12970 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AXA63_13000 ENOG4105JAB phenazine biosynthesis protein, phzf family AXA63_13005 ENOG4108ETY sodium dicarboxylate symporter AXA63_13010 ENOG4105EGI Transcriptional regulator AXA63_13015 ENOG4105CBP Major Facilitator AXA63_13035 ENOG4108R99 pseudouridine synthase AXA63_13040 ENOG4105E9K Isocitrate dehydrogenase AXA63_13050 ENOG4105DZ1 carboxypeptidase AXA63_13055 ENOG4105CEP NADH dehydrogenase AXA63_13060 ENOG4108YZY peptidylprolyl cis-trans isomerase AXA63_13065 ENOG4105CVP deoxyribo-dipyrimidine photolyase AXA63_13080 ENOG4107R8N Glycosyl transferase, family 2 AXA63_13110 ENOG4105EA8 2-Nitropropane dioxygenase AXA63_13115 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AXA63_13450 ENOG4107QS8 (LipO)protein AXA63_13485 ENOG4105DTR rard protein AXA63_13495 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AXA63_13505 ENOG4105BZU Histidine kinase AXA63_13540 ENOG4105EMU Dehydrogenase AXA63_13545 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AXA63_13550 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AXA63_13555 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AXA63_13565 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AXA63_13580 ENOG4105C3F Signal peptidase i AXA63_13595 ENOG4105C0H protease AXA63_13600 ENOG4108IYU L-aspartate oxidase AXA63_13615 ENOG4105HHA aminodeoxychorismate lyase AXA63_13620 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AXA63_13625 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AXA63_13635 ENOG4108I5D sulfate abc transporter AXA63_13645 ENOG4108IJ6 ABC transporter AXA63_13650 ENOG4107R11 Transcriptional regulator AXA63_13665 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AXA63_13670 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AXA63_13685 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AXA63_13700 ENOG4108UKI Enoyl-CoA hydratase AXA63_13705 ENOG4105EGD dinuclear metal center protein, YbgI family AXA63_13715 ENOG4105C2C drug resistance transporter, Bcr CflA AXA63_13720 ENOG4108ETH Formylglycinamide ribotide synthetase AXA63_13740 ENOG4105CH2 amidohydrolase AXA63_13745 ENOG4107YD3 Thioesterase AXA63_13750 ENOG4105E02 MotA TolQ exbB proton channel AXA63_13755 ENOG4105M8F Biopolymer transport protein exbD tolR AXA63_13765 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AXA63_13770 ENOG4105KCK Peptidoglycan-associated lipoprotein AXA63_13835 ENOG4105C02 permease AXA63_13845 ENOG4108V3E phosphoribosylglycinamide formyltransferase AXA63_13850 ENOG4107R6F Alpha Beta Hydrolase Fold protein AXA63_13855 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AXA63_13865 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AXA63_13870 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AXA63_13875 ENOG4105D60 lipoprotein releasing system transmembrane protein AXA63_13905 ENOG4107KET secretion protein, HlyD family AXA63_13940 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXA63_13945 ENOG4105C10 Electron transfer flavoprotein AXA63_13950 ENOG4105BZJ Electron transfer flavoprotein AXA63_13955 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXA63_13960 ENOG4105N14 lysine exporter protein LysE YggA AXA63_13970 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AXA63_13980 ENOG4105C85 amino acid AXA63_13985 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AXA63_13995 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AXA63_14010 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AXA63_14015 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AXA63_14020 ENOG4105BZW Glycerate kinase AXA63_14060 ENOG4105CEY Amp-dependent synthetase and ligase AXA63_14075 ENOG4108RRZ Transcription elongation factor GreB AXA63_14095 ENOG4105E4C Lytic transglycosylase catalytic AXA63_14110 ENOG4105BZS acriflavin resistance protein AXA63_14115 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AXA63_14125 ENOG41080IJ Diacylglycerol kinase AXA63_14145 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AXA63_14160 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AXA63_14165 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AXA63_14170 ENOG4105CSH Transporter AXA63_14220 ENOG4105EEI dihydropteroate synthase AXA63_14225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AXA63_14235 ENOG4105HBR Rna-binding protein AXA63_14250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AXA63_14255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AXA63_14270 ENOG41080TK Universal stress protein AXA63_14285 ENOG4105PNM synthesis protein AXA63_14305 ENOG4105EEQ Na H antiporter AXA63_14310 ENOG4105CGZ zinc metallopeptidase AXA63_14315 ENOG4105CKW Inner membrane protein yedI AXA63_14325 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AXA63_14335 ENOG4107QN2 dihydrolipoyl dehydrogenase AXA63_14340 ENOG4105C7S Dehydrogenase AXA63_14345 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AXA63_14350 ENOG4105E33 succinate dehydrogenase AXA63_14360 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AXA63_14365 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AXA63_14400 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AXA63_14405 ENOG41084BA UPF0250 protein AXA63_14410 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AXA63_14425 ENOG4105CUB amino acid AXA63_14435 ENOG4105KVH Transcriptional regulator AXA63_14440 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AXA63_14445 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AXA63_14460 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AXA63_14490 ENOG410841Q phosphoesterase PA-phosphatase related protein AXA63_14495 ENOG4105C1P efflux transporter, rnd family, mfp subunit AXA63_14500 ENOG4105BZS acriflavin resistance protein AXA63_14505 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AXA63_14510 ENOG4105K8R UPF0145 protein AXA63_14515 ENOG4105K8R UPF0145 protein AXA63_14535 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AXA63_14555 ENOG4108M0I Transcriptional regulator AXA63_14570 ENOG4105DHQ Histidine kinase AXA63_14575 ENOG4105XJC Two component transcriptional regulator (Winged helix family AXA63_14580 ENOG4105DIJ Phosphoethanolamine transferase AXA63_14600 ENOG4105D78 K07001 NTE family protein AXA63_14615 ENOG4105MSB protein, conserved in bacteria AXA63_14620 ENOG4105CTB Polyprenyl synthetase AXA63_14625 ENOG4105C7F AcnD-accessory protein PrpF AXA63_14630 ENOG4105C85 amino acid AXA63_14650 ENOG4105CF7 AraC family transcriptional regulator AXA63_14675 ENOG4108X0B nad(p)h dehydrogenase (quinone) AXA63_14685 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein AXA63_14695 ENOG4105D8T Acyltransferase AXA63_14705 ENOG4105C03 ribonuclease AXA63_14710 ENOG4108Z03 MAF-like protein AXA63_14715 ENOG4105VQ7 Rod shape-determining protein MreD AXA63_14720 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AXA63_14725 ENOG4105DFF Rod shape-determining protein mreb AXA63_14730 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AXA63_14740 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AXA63_14775 ENOG4105C7B Threonine dehydratase AXA63_14780 ENOG4105D78 K07001 NTE family protein AXA63_14785 ENOG4105BZG amino acid carrier protein AXA63_14800 ENOG4105C2C drug resistance transporter, Bcr CflA AXA63_14805 ENOG4105EM2 membrane AXA63_14815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AXA63_14855 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AXA63_14860 ENOG4105WD1 Membrane AXA63_14870 ENOG4106HKS Entericidin EcnA/B family AXA63_14885 ENOG4105CBS Chea signal transduction histidine kinase AXA63_14890 ENOG4105C8Q Methyl-accepting chemotaxis AXA63_14895 ENOG4108ZGA chew protein AXA63_14900 ENOG4105M3Z response regulator AXA63_14905 ENOG4108UNF response regulator AXA63_14930 ENOG4105KWI UPF0339 protein AXA63_14935 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AXA63_14940 ENOG4105K78 MarR family Transcriptional regulator AXA63_14950 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AXA63_14955 ENOG4105T95 Thiol disulfide interChange protein AXA63_14970 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXA63_14995 ENOG4108VX5 3-methyladenine DNA glycosylase AXA63_15005 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AXA63_15025 ENOG4105C2W permease AXA63_15035 ENOG4108IQI permease AXA63_15040 ENOG4105E0Y RtcB Protein AXA63_15050 ENOG4108WHA ompa motb domain protein AXA63_15060 ENOG4105CHU acetyl-coa acetyltransferase AXA63_15070 ENOG410814C multidrug resistance protein AXA63_15080 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AXA63_15085 ENOG4105DZG Dehydrogenase AXA63_15090 ENOG4105TW1 Carbohydrate-selective porin OprB AXA63_15100 ENOG4108R6W Transcriptional regulator, ARAC family AXA63_15105 ENOG4105CHU acetyl-coa acetyltransferase AXA63_15135 ENOG4108UT2 hemolysin iii AXA63_15140 ENOG4105CSH Transporter AXA63_15155 ENOG4105D3R alkyl hydroperoxide reductase AXA63_15175 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AXA63_15210 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AXA63_15225 ENOG4108WBT adenosyltransferase AXA63_15245 ENOG4105CNG UPF0061 protein AXA63_15250 ENOG4105E3W Two component transcriptional regulator (Winged helix family AXA63_15255 ENOG4105EB3 Histidine kinase AXA63_15265 ENOG4105CSU acyl-Coa dehydrogenase AXA63_15270 ENOG4105CSU acyl-Coa dehydrogenase AXA63_15275 ENOG4108R4R Iron-regulated virulence regulatory protein AXA63_15280 ENOG4108K3A Glutathione S-transferase AXA63_15285 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AXA63_15305 ENOG4105UGU tonB-dependent Receptor AXA63_15345 ENOG4108PQP glycosyl transferase group 1 AXA63_15355 ENOG4107BJW polysaccharide deacetylase AXA63_15370 ENOG4105CM2 brancheD-chain amino acid aminotransferase AXA63_15375 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AXA63_15380 ENOG4105BZU Histidine kinase AXA63_15410 ENOG4105VIE preprotein translocase, subunit YajC AXA63_15415 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AXA63_15420 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AXA63_15425 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AXA63_15435 ENOG4105FFC UPF0187 protein AXA63_15440 ENOG4105DB7 PHP domain protein AXA63_15450 ENOG4105K9H YciI-like protein AXA63_15480 ENOG4105NAU thioesterase Superfamily protein AXA63_15490 ENOG4107U2T alpha beta AXA63_15495 ENOG4107QPB Beta-lactamase domain protein AXA63_15505 ENOG4107QN2 dihydrolipoyl dehydrogenase AXA63_15540 ENOG4108KHX Diguanylate cyclase AXA63_15545 ENOG4105UYK outer membrane protein a AXA63_15555 ENOG4107RZC phospholipase d AXA63_15565 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AXA63_15585 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AXA63_15590 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AXA63_15595 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AXA63_15605 ENOG4108UJD 30S ribosomal protein S9 AXA63_15610 ENOG4107MKT Stringent starvation protein a AXA63_15615 ENOG4105KB2 stringent starvation protein b AXA63_15635 ENOG4105C1G acyl-Coa dehydrogenase AXA63_15640 ENOG4107QX3 carboxylase AXA63_15655 ENOG4108RZE Tetr family transcriptional regulator AXA63_15660 ENOG4105C1G acyl-Coa dehydrogenase AXA63_15705 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AXA63_15710 ENOG4105D6S protein involved in catabolism of external DNA AXA63_15740 ENOG4105E4C Lytic transglycosylase catalytic AXA63_15750 ENOG4105C9A Phoh family AXA63_15780 ENOG4105CS1 NAD(P)H quinone oxidoreductase AXA63_15785 ENOG4107S2Z UPF0761 membrane protein AXA63_15795 ENOG4108K2B transcriptional regulator AXA63_15800 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AXA63_15845 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AXA63_15850 ENOG4105DGW oligopeptidase A AXA63_15855 ENOG4105VKU nucleicacid-binding protein AXA63_15890 ENOG4105C1G acyl-Coa dehydrogenase AXA63_15915 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AXA63_15925 ENOG41067V7 50S ribosomal protein L36 AXA63_15930 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AXA63_16040 ENOG41089BK Glutamine amido-transferase AXA63_16045 ENOG4105C28 cystathionine AXA63_16050 ENOG4105D7A ATP-binding protein AXA63_16060 ENOG4105KPV Transcriptional regulator AXA63_16075 ENOG4105CK2 sodium dicarboxylate symporter AXA63_16080 ENOG4105C29 acyl-CoA thioesterase AXA63_16100 ENOG4105CB5 ATP-dependent DNA helicase recG AXA63_16105 ENOG4105MJ2 Competence protein AXA63_16135 ENOG4105D7N magnesium and cobalt transport protein CorA AXA63_16145 ENOG4105E3I toluene tolerance AXA63_16155 ENOG4105CY3 ABC transporter, permease AXA63_16160 ENOG4105DHJ ABC, transporter AXA63_16170 ENOG4105C1J atp-dependent rna helicase AXA63_16175 ENOG4105ECY inositol monophosphatase AXA63_16190 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AXA63_16205 ENOG4105CSU acyl-Coa dehydrogenase AXA63_16215 ENOG41067S9 phage shock protein C, PspC AXA63_16220 ENOG4105W87 Cbs domain AXA63_16280 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AXA63_16305 ENOG4105C26 Dehydrogenase AXA63_16315 ENOG4105C8Y Acetylornithine aminotransferase AXA63_16320 ENOG4105D82 Glutamate dehydrogenase AXA63_16325 ENOG4108IQI permease AXA63_16355 ENOG4107SKI cobyrinic Acid a,c-diamide synthase AXA63_16360 ENOG4105IPI Membrane AXA63_16365 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AXA63_16370 ENOG4105EM2 membrane AXA63_16375 ENOG4107QF7 multi-drug AXA63_16385 ENOG4105NF4 modulator of drug activity AXA63_16390 ENOG4105VRH Antibiotic biosynthesis monooxygenase AXA63_16400 ENOG4105CQB FAD linked oxidase domain protein AXA63_16405 ENOG4108JQ1 Dehydrogenase AXA63_16430 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AXA63_16435 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) AXA63_16440 ENOG4107IFA Lipase (EC 3.1.1.3) AXA63_16455 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AXA63_16505 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AXA63_16515 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AXA63_16520 ENOG4105KME endoribonuclease L-psp AXA63_16530 ENOG4108UQY Iron-storage protein AXA63_16535 ENOG4108YSG O-Antigen polymerase AXA63_16555 ENOG4105HA9 of methanol dehydrogenase type AXA63_16560 ENOG4108V0P LemA family AXA63_16570 ENOG4105BZ8 glutamate synthase AXA63_16575 ENOG4105CBC glutamate synthase AXA63_16595 ENOG4105E4G Type IV pilus AXA63_16620 ENOG4108JQC penicillin-binding protein 1A AXA63_16625 ENOG4105DHI Methyltransferase AXA63_16640 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AXA63_16645 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AXA63_16650 ENOG4105CJN penicillin-binding protein AXA63_16665 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AXA63_16690 ENOG4108IQI permease AXA63_16770 ENOG4105C5H ABC transporter AXA63_16780 ENOG4105PDP Short chain dehydrogenase AXA63_16785 ENOG4105CHH sulfate transporter AXA63_16795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AXA63_16800 ENOG4105E0F Histidine kinase AXA63_16805 ENOG4105CYC Transferase AXA63_16835 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AXA63_16865 ENOG41061CK Antibiotic biosynthesis monooxygenase AXA63_16880 ENOG4105CUV Homoserine Kinase AXA63_16945 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AXA63_16950 ENOG4105KVH Transcriptional regulator AXA63_16975 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) AXA63_16980 ENOG4105CPC Aldo Keto reductase AXA63_17000 ENOG4106NZI LysR family Transcriptional regulator AXA63_17005 ENOG4105D94 Major Facilitator Superfamily AXA63_17030 ENOG4105EUB pirin domain protein AXA63_17035 ENOG4105CHJ isochorismatase hydrolase AXA63_17045 ENOG4105C26 Dehydrogenase AXA63_17050 ENOG4108JPW Aminotransferase AXA63_17060 ENOG4105C85 amino acid AXA63_17070 ENOG4108UMN azlc family AXA63_17080 ENOG4108UUM single-stranded DNA-binding protein AXA63_17085 ENOG4107RDB Major Facilitator AXA63_17095 ENOG4105DWF phosphomethylpyrimidine kinase AXA63_17100 ENOG4105RA2 Membrane AXA63_17110 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AXA63_17115 ENOG4108WUH Transcriptional regulator, TetR family AXA63_17120 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AXA63_17130 ENOG4105BZU Histidine kinase AXA63_17140 ENOG4105C94 Transporter AXA63_17150 ENOG4107QN1 sodium solute AXA63_17155 ENOG41062QD Membrane AXA63_17160 ENOG4105BZU Histidine kinase AXA63_17175 ENOG4108UZX fmn reductase AXA63_17180 ENOG4105FBW Monooxygenase AXA63_17185 ENOG4105D5G Transposase AXA63_17195 ENOG4108W2Y isochorismatase AXA63_17200 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AXA63_17210 ENOG4105D64 Mechanosensitive ion channel AXA63_17220 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AXA63_17225 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AXA63_17235 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AXA63_17245 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AXA63_17260 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AXA63_17275 ENOG4105E0K tonB-dependent siderophore receptor AXA63_17290 ENOG4107QSN dihydrolipoamide acetyltransferase AXA63_17295 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AXA63_17300 ENOG41063SB peptidase AXA63_17315 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AXA63_17320 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AXA63_17325 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AXA63_17345 ENOG4105D7Z glutathione synthase AXA63_17365 ENOG4105CGK Exodeoxyribonuclease III AXA63_17370 ENOG4105KUZ arsenate reductase AXA63_17385 ENOG4105BZU Histidine kinase AXA63_17390 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AXA63_17420 ENOG41084YZ Hydrolase AXA63_17435 ENOG41061H0 Monooxygenase AXA63_17445 ENOG4108Z2U ureidoglycolate hydrolase AXA63_17450 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AXA63_17455 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXA63_17460 ENOG4105IPS esterase AXA63_17485 ENOG4105CS6 Rhs element vgr protein AXA63_17495 ENOG4105D9M gamma-glutamylcysteine synthetase AXA63_17510 ENOG4106BRA Membrane AXA63_17515 ENOG4105CHM Aminotransferase AXA63_17520 ENOG4107QJQ Mate efflux family protein AXA63_17535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AXA63_17540 ENOG4105BZU Histidine kinase AXA63_17570 ENOG4105KHC sulfurtransferase AXA63_17605 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AXA63_17620 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AXA63_17625 ENOG4108ZAI phosphatidylglycerophosphatase a AXA63_17635 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AXA63_17640 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AXA63_17655 ENOG41088SP formiminoglutamate hydrolase AXA63_17665 ENOG4105C85 amino acid AXA63_17680 ENOG41090B9 response to stress AXA63_17685 ENOG4105CZE histidine utilization repressor AXA63_17695 ENOG4105CKI cobalamin synthesis protein AXA63_17705 ENOG4105C85 amino acid AXA63_17715 ENOG4108RXX maleylacetoacetate isomerase AXA63_17735 ENOG4105EWC Purine nucleoside phosphorylase AXA63_17740 ENOG4107QI1 Mate efflux family protein AXA63_17745 ENOG4105C09 Bile acid AXA63_17750 ENOG4108RWI nicotinamidase AXA63_17755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXA63_17775 ENOG4105S64 Formate nitrite transporter AXA63_17780 ENOG4105D1H recombination factor protein RarA AXA63_17790 ENOG4108ZZ3 UPF0260 protein AXA63_17810 ENOG4105CEN a g-specific adenine glycosylase AXA63_17825 ENOG4108R3E Dna-3-methyladenine glycosylase i AXA63_17830 ENOG4105DQ4 alcohol dehydrogenase AXA63_17845 ENOG4105HEI LysR family (Transcriptional regulator AXA63_17850 ENOG4105CV8 reductase AXA63_17855 ENOG4105F27 Major Facilitator AXA63_17890 ENOG4105DJY efflux transporter, rnd family, mfp subunit AXA63_17895 ENOG4108IG5 Transcriptional regulator AXA63_17905 ENOG4105C2W permease AXA63_17935 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AXA63_18000 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AXA63_18005 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AXA63_18010 ENOG4105D74 hydrolase AXA63_18020 ENOG4108821 RND type efflux pump AXA63_18025 ENOG4108821 RND type efflux pump AXA63_18030 ENOG4108821 RND type efflux pump AXA63_18035 ENOG4105C5H ABC transporter AXA63_18040 ENOG4105DQR SNARE associated Golgi AXA63_18050 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXA63_18060 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AXA63_18070 ENOG4105VG0 50S ribosomal protein l34 AXA63_18085 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AXA63_18100 ENOG4105PGM cation diffusion facilitator family transporter AXA63_18105 ENOG4105T95 Thiol disulfide interChange protein AXA63_18115 ENOG4108UGV hypoxanthine phosphoribosyltransferase AXA63_18125 ENOG4107QUY Guanine deaminase AXA63_18135 ENOG4106032 Glutathionylspermidine synthase AXA63_18145 ENOG4105DU1 integral membrane protein, terc AXA63_18150 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AXA63_18160 ENOG4105DFU Cell wall formation (By similarity) AXA63_18170 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AXA63_18175 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AXA63_18180 ENOG4105CVE Lytic murein transglycosylase AXA63_18235 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AXA63_18275 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AXA63_18285 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AXA63_18290 ENOG4105DTN riboflavin biosynthesis protein ribF AXA63_18300 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AXA63_18305 ENOG4108R86 Transcriptional regulator AXA63_18310 ENOG4108VM9 ABC, transporter AXA63_18315 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AXA63_18320 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AXA63_18325 ENOG4105GVF (ABC) transporter AXA63_18330 ENOG4105GVF (ABC) transporter AXA63_18335 ENOG4107QZM n-acetylglutamate synthase AXA63_18350 ENOG4105UBK short-chain dehydrogenase reductase AXA63_18355 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AXA63_18370 ENOG41062JF Transcriptional regulator AXA63_18405 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AXA63_18410 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AXA63_18415 ENOG4105CJR Integral membrane protein (MviN AXA63_18420 ENOG4108V1T peptidylprolyl cis-trans isomerase AXA63_18425 ENOG4108V1T peptidylprolyl cis-trans isomerase AXA63_18430 ENOG4105D75 Capsular exopolysaccharide family AXA63_18440 ENOG4105DAY polysaccharide export protein AXA63_18445 ENOG4107QQG Dehydrogenase AXA63_18490 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AXA63_18505 ENOG4107UKG Glycosyl transferase, family 4 AXA63_18510 ENOG4105D3Q Sugar transferase AXA63_18515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AXA63_18520 ENOG4105C6Y Udp-glucose 6-dehydrogenase AXA63_18530 ENOG4105CMR udp-glucose 4-epimerase AXA63_18535 ENOG4107QKV phosphomannomutase AXA63_18540 ENOG4105DAA L-lactate AXA63_18545 ENOG41073TP transcriptional regulator AXA63_18555 ENOG4105CXG d-lactate dehydrogenase AXA63_18560 ENOG4105CGF Aromatic amino acid aminotransferase AXA63_18565 ENOG4105DRR Transcriptional regulator, GntR family AXA63_18570 ENOG4105CR4 methylisocitrate lyase AXA63_18575 ENOG4105BZN citrate synthase AXA63_18580 ENOG4108I0Z Aconitate hydratase AXA63_18640 ENOG4105D3G Pseudouridine synthase AXA63_18665 ENOG4105EW9 transcriptional regulator AsnC family AXA63_18680 ENOG4105M4H endoribonuclease L-psp AXA63_18685 ENOG4105C85 amino acid AXA63_18690 ENOG4105C85 amino acid AXA63_18700 ENOG4105C26 Dehydrogenase AXA63_18705 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AXA63_18715 ENOG4105C1G acyl-Coa dehydrogenase AXA63_18720 ENOG4105E39 Enoyl-CoA hydratase AXA63_18725 ENOG4105E39 Enoyl-CoA hydratase AXA63_18730 ENOG4105CSH Transporter AXA63_18760 ENOG4105C1G acyl-Coa dehydrogenase AXA63_18805 ENOG4107PSF BolA-like protein AXA63_18815 ENOG4107QJE Chromosome Partitioning Protein AXA63_18830 ENOG4105DQR SNARE associated Golgi AXA63_18835 ENOG4108VBZ doxx family AXA63_18840 ENOG4106MP8 UPF0754 membrane protein AXA63_18845 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AXA63_18865 ENOG4105EUB pirin domain protein AXA63_18890 ENOG4107R1I NAD-dependent malic enzyme AXA63_18895 ENOG4105EZR dyp-type peroxidase family protein AXA63_18905 ENOG4105FAV ABC, transporter AXA63_18910 ENOG4105FDK ABC transporter AXA63_18935 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AXA63_18975 ENOG4108V06 Glutathione peroxidase AXA63_18985 ENOG4107RTG Major Facilitator superfamily AXA63_18990 ENOG4108IND Tetr family transcriptional regulator AXA63_19005 ENOG4105C79 DNA protecting protein DprA AXA63_19040 ENOG4105Y7M Transcriptional regulator, TetR family AXA63_19075 ENOG4105C6T cysteine synthase AXA63_19085 ENOG4105CS1 NAD(P)H quinone oxidoreductase AXA63_19105 ENOG4105CCT upf0313 protein AXA63_19120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AXA63_19135 ENOG4108URH decarboxylase AXA63_19140 ENOG4105EE5 Membrane protein terC AXA63_19150 ENOG4105EN6 Membrane AXA63_19155 ENOG41079KZ Major Facilitator Superfamily AXA63_19160 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AXA63_19165 ENOG4105CEY Amp-dependent synthetase and ligase AXA63_19180 ENOG4105F0N pyrophosphate phospho-hydrolase AXA63_19185 ENOG4105EPF Outer membrane porin AXA63_19195 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AXA63_19205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AXA63_19245 ENOG4105CHH sulfate transporter AXA63_19270 ENOG4105BZU Histidine kinase AXA63_19280 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AXA63_19320 ENOG4108K5H permease YjgP YjgQ family protein AXA63_19325 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AXA63_19330 ENOG4105CN1 protease AXA63_19335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AXA63_19340 ENOG4107TUY Histidine kinase AXA63_19350 ENOG41061WM D-Alanyl-D-Alanine AXA63_19360 ENOG4105D6E homoserine dehydrogenase AXA63_19365 ENOG4105T95 Thiol disulfide interChange protein AXA63_19370 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AXA63_19380 ENOG4105CE1 Ferrous iron transport protein b AXA63_19395 ENOG4105CNI cell division protein FtsW AXA63_19400 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AXA63_19405 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AXA63_19410 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AXA63_19435 ENOG4108RNG Permease of the drug metabolite transporter AXA63_19440 ENOG4105DFG type I secretion outer membrane protein AXA63_19445 ENOG4108UTW Plays a role in the regulation of phosphate uptake AXA63_19460 ENOG4108HRK Histidine kinase AXA63_19465 ENOG4108NEV two component transcriptional regulator, LytTR family AXA63_19470 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AXA63_19495 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS AXA63_19510 ENOG4105GVR general secretion pathway protein D AXA63_19515 ENOG4105TV9 FHA Domain-Containing protein AXA63_19520 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AXA63_19560 ENOG4105PM1 preprotein translocase subunit SecE AXA63_19565 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AXA63_19615 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AXA63_19620 ENOG4105D3Y Na H antiporter AXA63_19635 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AXA63_19850 ENOG4105K5T PilT protein AXA63_19885 ENOG4105T95 Thiol disulfide interChange protein AXA63_19965 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AXA63_20055 ENOG4105KK6 nuclease AXA63_20060 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS AXA63_20125 ENOG4105FA0 parb-like partition protein