locus-tag	class	description
N7297_00010	COG1183	phosphatidylcholine synthase activity
N7297_00015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N7297_00045	COG0739	heme binding
N7297_00045	COG0741	lytic transglycosylase activity
N7297_00045	COG1196	nuclear chromosome segregation
N7297_00055	COG1702	phosphate starvation-inducible protein PhoH
N7297_00090	COG1295	ribonuclease BN
N7297_00095	COG0697	spore germination
N7297_00100	COG2169	Transcriptional regulator
N7297_00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
N7297_00150	COG0557	exoribonuclease II activity
N7297_00155	COG0339	signal peptide processing
N7297_00160	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N7297_00190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N7297_00195	COG1960	acyl-CoA dehydrogenase activity
N7297_00350	COG0626	cystathionine gamma-synthase activity
N7297_00355	COG0433	COG0433 Predicted ATPase
N7297_00360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N7297_00360	COG1017	nitric oxide dioxygenase activity
N7297_00365	COG1959	2 iron, 2 sulfur cluster binding
N7297_00380	COG1301	dicarboxylic acid transport
N7297_00385	COG1946	Acyl-CoA thioesterase
N7297_00405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N7297_00410	COG1040	competence protein
N7297_00415	COG0494	nUDIX hydrolase
N7297_00425	COG0598	Magnesium transport protein CorA
N7297_00435	COG2854	intermembrane phospholipid transfer
N7297_00445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N7297_00450	COG1127	ABC transporter
N7297_00460	COG0513	Belongs to the DEAD box helicase family
N7297_00480	COG0408	coproporphyrinogen oxidase activity
N7297_00495	COG1960	acyl-CoA dehydrogenase activity
N7297_00505	COG1983	PspC domain protein
N7297_00510	COG0517	IMP dehydrogenase activity
N7297_00555	COG0583	DNA-binding transcription factor activity
N7297_00595	COG1012	belongs to the aldehyde dehydrogenase family
N7297_00605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N7297_00610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N7297_00615	COG0833	amino acid
N7297_00645	COG1192	Involved in chromosome partitioning
N7297_00650	COG0628	permease
N7297_00660	COG1289	transmembrane transporter activity
N7297_00675	COG2249	NAD(P)H dehydrogenase (quinone) activity
N7297_00680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N7297_00690	COG0277	FAD linked oxidase domain protein
N7297_00695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N7297_00720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N7297_00725	COG5380	lipid catabolic process
N7297_00745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N7297_00795	COG0194	GDP metabolic process
N7297_00810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N7297_00830	COG3307	-O-antigen
N7297_00850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
N7297_00855	COG1704	LemA family
N7297_00865	COG0493	'glutamate synthase
N7297_00870	COG0070	glutamate synthase
N7297_00870	COG0069	glutamate synthase activity
N7297_00870	COG0067	glutamate synthase
N7297_00920	COG2226	methyltransferase
N7297_00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N7297_00940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N7297_00985	COG0833	amino acid
N7297_01070	COG0488	(ABC) transporter
N7297_01075	COG2873	o-acetylhomoserine
N7297_01080	COG4221	oxidoreductase activity
N7297_01085	COG0659	secondary active sulfate transmembrane transporter activity
N7297_01110	COG0427	acetyl-CoA hydrolase
N7297_01140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N7297_01170	COG2329	Antibiotic biosynthesis monooxygenase
N7297_01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N7297_01250	COG2249	NAD(P)H dehydrogenase (quinone) activity
N7297_01255	COG1733	regulation of RNA biosynthetic process
N7297_01290	COG0667	Aldo Keto reductase
N7297_01310	COG0583	DNA-binding transcription factor activity
N7297_01315	COG2814	Major facilitator Superfamily
N7297_01345	COG1335	isochorismatase
N7297_01355	COG1012	belongs to the aldehyde dehydrogenase family
N7297_01360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N7297_01370	COG1113	amino acid transport
N7297_01380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N7297_01395	COG2814	Major facilitator Superfamily
N7297_01405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N7297_01405	COG0352	thiamine-phosphate diphosphorylase activity
N7297_01405	COG0351	phosphomethylpyrimidine kinase
N7297_01425	COG1309	transcriptional regulator
N7297_01430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N7297_01450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N7297_01460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N7297_01465	COG3162	membrane
N7297_01470	COG2205	protein histidine kinase activity
N7297_01470	COG0784	Response regulator, receiver
N7297_01470	COG2198	Histidine kinase
N7297_01495	COG3328	transposase activity
N7297_01500	COG1522	sequence-specific DNA binding
N7297_01505	COG1335	isochorismatase
N7297_01510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N7297_01520	COG0668	transmembrane transport
N7297_01525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N7297_01530	COG1519	Transferase
N7297_01535	COG1902	pentaerythritol trinitrate reductase activity
N7297_01555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N7297_01580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N7297_01580	COG0426	domain, Protein
N7297_01585	COG4774	siderophore transport
N7297_01590	COG2119	membrane
N7297_01600	COG0508	dehydrogenase complex catalyzes the overall conversion of
N7297_01610	COG4942	peptidase
N7297_01625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N7297_01635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N7297_01655	COG0189	ligase activity
N7297_01675	COG0708	Exodeoxyribonuclease III
N7297_01680	COG1393	Belongs to the ArsC family
N7297_01695	COG3706	GGDEF domain
N7297_01730	COG2351	hydroxyisourate hydrolase activity
N7297_01735	COG2233	PERMEase
N7297_01745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N7297_01755	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
N7297_01760	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_01770	COG3150	esterase
N7297_01785	COG1388	LysM domain
N7297_01785	COG0791	NLP P60 protein
N7297_01800	COG2918	glutathione biosynthetic process
N7297_01815	COG2733	membrane
N7297_01820	COG0436	Aminotransferase
N7297_01825	COG0534	Mate efflux family protein
N7297_01925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N7297_01930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N7297_01940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N7297_01945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N7297_01960	COG0010	Belongs to the arginase family
N7297_01990	COG2188	Transcriptional regulator
N7297_02000	COG0523	cobalamin synthesis protein
N7297_02010	COG1113	amino acid transport
N7297_02020	COG0625	glutathione transferase activity
N7297_02040	COG1683	Conserved Protein
N7297_02045	COG0534	Mate efflux family protein
N7297_02050	COG0385	Bile acid
N7297_02055	COG1335	isochorismatase
N7297_02060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N7297_02080	COG2116	formate transmembrane transporter activity
N7297_02085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N7297_02090	COG2133	pyrroloquinoline quinone binding
N7297_02095	COG2983	Belongs to the UPF0260 family
N7297_02115	COG1194	a g-specific adenine glycosylase
N7297_02130	COG2818	Glycosylase
N7297_02135	COG1064	alcohol dehydrogenase
N7297_02140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N7297_02155	COG0583	DNA-binding transcription factor activity
N7297_02160	COG0656	L-ascorbic acid biosynthetic process
N7297_02165	COG2814	Major facilitator Superfamily
N7297_02200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7297_02215	COG2233	PERMEase
N7297_02255	COG0733	neurotransmitter:sodium symporter activity
N7297_02295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N7297_02300	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N7297_02305	COG0596	Alpha beta hydrolase
N7297_02330	COG0488	(ABC) transporter
N7297_02335	COG0586	Pfam SNARE associated Golgi protein
N7297_02345	COG0187	DNA topoisomerase II activity
N7297_02355	COG0592	DNA-directed DNA polymerase activity
N7297_02380	COG0706	membrane insertase activity
N7297_02395	COG1230	cation diffusion facilitator family transporter
N7297_02400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7297_02415	COG0402	S-adenosylhomocysteine deaminase activity
N7297_02425	COG0754	glutathionylspermidine amidase activity
N7297_02435	COG0861	Integral membrane protein TerC family
N7297_02440	COG0671	phosphoesterase, PA-phosphatase related
N7297_02450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N7297_02465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N7297_02470	COG2951	lytic endotransglycosylase activity
N7297_02500	COG0583	DNA-binding transcription factor activity
N7297_02520	COG0657	acetylesterase activity
N7297_02525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N7297_02565	COG1047	Peptidyl-prolyl cis-trans
N7297_02575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N7297_02580	COG0196	riboflavin kinase activity
N7297_02590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N7297_02595	COG1309	transcriptional regulator
N7297_02600	COG1116	anion transmembrane transporter activity
N7297_02605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N7297_02610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N7297_02615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N7297_02620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N7297_02640	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_02645	COG0546	phosphoglycolate phosphatase activity
N7297_02705	COG3023	N-Acetylmuramoyl-L-alanine amidase
N7297_02710	COG0728	peptidoglycan biosynthetic process
N7297_02735	COG1596	polysaccharide export
N7297_02740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N7297_02750	COG1216	Glycosyl transferase, family 2
N7297_02750	COG1442	glycosyl transferase family 8
N7297_02760	COG1216	Glycosyl transferase, family 2
N7297_02770	COG1216	Glycosyl transferase, family 2
N7297_02775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N7297_02780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N7297_02795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N7297_02805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N7297_02815	COG2186	Transcriptional regulator
N7297_02825	COG0277	FAD linked oxidase domain protein
N7297_02830	COG1448	Aminotransferase
N7297_02840	COG1802	Transcriptional regulator
N7297_02855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N7297_02915	COG0564	pseudouridine synthase activity
N7297_02955	COG0251	oxidation-reduction process
N7297_02960	COG1113	amino acid transport
N7297_02965	COG1113	amino acid transport
N7297_02985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N7297_02990	COG1960	acyl-CoA dehydrogenase activity
N7297_02995	COG1024	Enoyl-CoA hydratase
N7297_03000	COG1024	Enoyl-CoA hydratase
N7297_03005	COG0477	Major facilitator Superfamily
N7297_03010	COG3916	Acyl-homoserine-lactone synthase
N7297_03020	COG2197	response regulator
N7297_03030	COG1960	acyl-CoA dehydrogenase activity
N7297_03035	COG3321	synthase
N7297_03035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N7297_03035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N7297_03035	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
N7297_03055	COG2267	carboxylic ester hydrolase activity
N7297_03075	COG0271	Belongs to the BolA IbaG family
N7297_03085	COG1192	Involved in chromosome partitioning
N7297_03100	COG0586	Pfam SNARE associated Golgi protein
N7297_03105	COG2259	Doxx family
N7297_03110	COG4399	Belongs to the UPF0754 family
N7297_03115	COG0519	Catalyzes the synthesis of GMP from XMP
N7297_03115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N7297_03160	COG0281	malic enzyme
N7297_03170	COG2837	iron assimilation
N7297_03175	COG1280	lysine exporter protein (LysE YggA)
N7297_03180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N7297_03185	COG1121	(ABC) transporter
N7297_03250	COG0386	Belongs to the glutathione peroxidase family
N7297_03265	COG1309	transcriptional regulator
N7297_03270	COG0697	spore germination
N7297_03280	COG0758	DNA mediated transformation
N7297_03350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N7297_03360	COG0655	NAD(P)H dehydrogenase (quinone) activity
N7297_03400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N7297_03420	COG1253	flavin adenine dinucleotide binding
N7297_03430	COG2860	membrane
N7297_03435	COG0477	Major facilitator Superfamily
N7297_03445	COG0318	PFAM AMP-dependent synthetase and ligase
N7297_03460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N7297_03480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N7297_03525	COG0589	response to stress
N7297_03530	COG0659	secondary active sulfate transmembrane transporter activity
N7297_03540	COG1002	Type II restriction enzyme, methylase subunits
N7297_03545	COG1061	Type III restriction enzyme res subunit
N7297_03620	COG0347	Belongs to the P(II) protein family
N7297_03625	COG0004	ammonium transporteR
N7297_03635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N7297_03635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N7297_03675	COG0795	lipopolysaccharide-transporting ATPase activity
N7297_03680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N7297_03685	COG0793	Belongs to the peptidase S41A family
N7297_03700	COG2197	response regulator
N7297_03710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N7297_03720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7297_03725	COG4974	Belongs to the 'phage' integrase family
N7297_03750	COG0772	Belongs to the SEDS family
N7297_03755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N7297_03760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N7297_03765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N7297_03790	COG0697	spore germination
N7297_03795	COG1538	Outer membrane efflux protein
N7297_03815	COG3275	phosphorelay sensor kinase activity
N7297_03825	COG0181	hydroxymethylbilane synthase activity
N7297_03870	COG1716	ATPase activity
N7297_03875	COG0546	phosphoglycolate phosphatase activity
N7297_03970	COG0596	Alpha beta hydrolase
N7297_03975	COG2056	Na+-H+ antiporter family
N7297_03990	COG0326	Molecular chaperone. Has ATPase activity
N7297_04005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N7297_04070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N7297_04075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N7297_04075	COG2169	Transcriptional regulator
N7297_04105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N7297_04115	COG0497	DNA recombination
N7297_04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N7297_04140	COG0237	dephospho-CoA kinase activity
N7297_04190	COG0195	Participates in both transcription termination and antitermination
N7297_04205	COG1320	monovalent cation:proton antiporter activity
N7297_04210	COG2212	antiporter activity
N7297_04215	COG1863	multisubunit Na H antiporter MnhE subunit
N7297_04220	COG0651	ATP synthesis coupled electron transport
N7297_04225	COG1006	Multisubunit Na H antiporter MnhC subunit
N7297_04230	COG2111	Na H antiporter
N7297_04230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N7297_04245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N7297_04250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N7297_04265	COG2226	methyltransferase
N7297_04285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N7297_04290	COG1074	ATP-dependent DNA helicase activity
N7297_04295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N7297_04300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N7297_04315	COG0598	Magnesium transport protein CorA
N7297_04320	COG0789	Transcriptional regulator
N7297_04325	COG0484	heat shock protein binding
N7297_04335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N7297_04340	COG0475	glutathione-regulated potassium exporter activity
N7297_04340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N7297_04345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N7297_04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N7297_04375	COG4535	Mg2 and Co2 transporter CorC
N7297_04380	COG0425	Belongs to the sulfur carrier protein TusA family
N7297_04385	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
N7297_04385	COG0644	oxidoreductase
N7297_04395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N7297_04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N7297_04415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N7297_04455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N7297_04470	COG0534	Mate efflux family protein
N7297_04480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N7297_04485	COG4221	oxidoreductase activity
N7297_04490	COG0583	DNA-binding transcription factor activity
N7297_04505	COG0318	PFAM AMP-dependent synthetase and ligase
N7297_04510	COG1530	ribonuclease E activity
N7297_04520	COG0546	phosphoglycolate phosphatase activity
N7297_04525	COG2378	regulation of single-species biofilm formation
N7297_04530	COG0625	glutathione transferase activity
N7297_04540	COG0583	DNA-binding transcription factor activity
N7297_04605	COG0473	3-isopropylmalate dehydrogenase activity
N7297_04660	COG1301	dicarboxylic acid transport
N7297_04670	COG1560	Kdo2-lipid A biosynthetic process
N7297_04675	COG1280	lysine exporter protein (LysE YggA)
N7297_04680	COG0488	(ABC) transporter
N7297_04685	COG2900	Belongs to the SlyX family
N7297_04695	COG1733	regulation of RNA biosynthetic process
N7297_04720	COG0210	DNA helicase
N7297_04725	COG0724	RNA recognition motif
N7297_04745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N7297_04745	COG4651	solute:proton antiporter activity
N7297_04770	COG0788	formyltetrahydrofolate deformylase activity
N7297_04870	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N7297_04870	COG2813	Specifically methylates the guanine in position
N7297_04880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N7297_04890	COG4774	siderophore transport
N7297_04900	COG0740	serine-type endopeptidase activity
N7297_04920	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N7297_04920	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N7297_04925	COG0280	phosphate acetyltransferase
N7297_04925	COG0857	belongs to the CobB CobQ family
N7297_04930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N7297_04945	COG0800	Aldolase
N7297_04955	COG3265	gluconokinase activity
N7297_04960	COG1012	belongs to the aldehyde dehydrogenase family
N7297_04970	COG2267	carboxylic ester hydrolase activity
N7297_04985	COG0793	Belongs to the peptidase S41A family
N7297_05020	COG1426	Protein conserved in bacteria
N7297_05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N7297_05075	COG0318	PFAM AMP-dependent synthetase and ligase
N7297_05090	COG2986	histidine ammonia-lyase
N7297_05130	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_05135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N7297_05155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N7297_05165	COG1162	GTPase activity
N7297_05170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N7297_05185	COG1538	Outer membrane efflux protein
N7297_05190	COG0577	efflux transmembrane transporter activity
N7297_05190	COG1136	(ABC) transporter
N7297_05195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7297_05220	COG0028	Belongs to the TPP enzyme family
N7297_05225	COG0440	acetolactate synthase activity
N7297_05255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N7297_05270	COG0084	hydrolase, TatD family'
N7297_05285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N7297_05295	COG0583	DNA-binding transcription factor activity
N7297_05305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N7297_05310	COG2814	Major facilitator Superfamily
N7297_05320	COG0697	spore germination
N7297_05350	COG3622	Belongs to the hyi family
N7297_05355	COG2084	Dehydrogenase
N7297_05360	COG1024	Enoyl-CoA hydratase
N7297_05365	COG0784	Response regulator, receiver
N7297_05365	COG2205	protein histidine kinase activity
N7297_05365	COG5002	protein histidine kinase activity
N7297_05385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N7297_05395	COG3956	TIGRFAM MazG family protein
N7297_05400	COG1555	photosystem II stabilization
N7297_05405	COG0617	tRNA 3'-terminal CCA addition
N7297_05410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N7297_05430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7297_05435	COG3028	Belongs to the UPF0307 family
N7297_05440	COG0318	PFAM AMP-dependent synthetase and ligase
N7297_05455	COG0625	glutathione transferase activity
N7297_05460	COG1238	metal cluster binding
N7297_05505	COG0072	phenylalanine-tRNA ligase activity
N7297_05535	COG0248	Ppx GppA phosphatase
N7297_05545	COG0037	tRNA processing
N7297_05595	COG1764	response to oxidative stress
N7297_05600	COG1846	Transcriptional regulator
N7297_05610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N7297_05670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N7297_05675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N7297_05680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N7297_05690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N7297_05745	COG1214	PFAM Peptidase M22, glycoprotease
N7297_05770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N7297_05775	COG0561	phosphatase activity
N7297_05785	COG2132	Multicopper oxidase
N7297_05790	COG3667	copper resistance
N7297_05805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N7297_05810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N7297_05815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N7297_05845	COG1063	alcohol dehydrogenase
N7297_05850	COG0583	DNA-binding transcription factor activity
N7297_05855	COG1960	acyl-CoA dehydrogenase activity
N7297_05860	COG2814	Major facilitator Superfamily
N7297_05865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N7297_05875	COG1053	succinate dehydrogenase
N7297_05880	COG0583	DNA-binding transcription factor activity
N7297_05895	COG0583	DNA-binding transcription factor activity
N7297_05925	COG0583	DNA-binding transcription factor activity
N7297_05940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N7297_05965	COG0384	phenazine biosynthesis protein PhzF
N7297_05990	COG4993	Dehydrogenase
N7297_06060	COG2205	protein histidine kinase activity
N7297_06070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N7297_06090	COG0745	RESPONSE REGULATOR receiver
N7297_06130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N7297_06160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N7297_06165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N7297_06185	COG0583	DNA-binding transcription factor activity
N7297_06205	COG0668	transmembrane transport
N7297_06215	COG2081	HI0933 family
N7297_06220	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N7297_06250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N7297_06250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N7297_06260	COG0489	protein tyrosine kinase activity
N7297_06310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N7297_06320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N7297_06335	COG0730	response to heat
N7297_06345	COG1196	nuclear chromosome segregation
N7297_06365	COG2223	nitrite transmembrane transporter activity
N7297_06370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N7297_06375	COG1877	trehalose-phosphatase activity
N7297_06380	COG0596	Alpha beta hydrolase
N7297_06380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N7297_06380	COG2226	methyltransferase
N7297_06395	COG4106	trans-aconitate 2-methyltransferase activity
N7297_06410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N7297_06415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N7297_06420	COG0009	L-threonylcarbamoyladenylate synthase
N7297_06425	COG3101	peptidyl-lysine hydroxylation
N7297_06430	COG1399	metal-binding, possibly nucleic acid-binding protein
N7297_06455	COG1652	LysM domain
N7297_06460	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N7297_06460	COG0352	thiamine-phosphate diphosphorylase activity
N7297_06460	COG0351	phosphomethylpyrimidine kinase
N7297_06470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N7297_06500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N7297_06530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N7297_06545	COG0358	DNA primase activity
N7297_06555	COG0564	pseudouridine synthase activity
N7297_06580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N7297_06600	COG0583	DNA-binding transcription factor activity
N7297_06605	COG0473	3-isopropylmalate dehydrogenase activity
N7297_06615	COG0657	acetylesterase activity
N7297_06625	COG1012	belongs to the aldehyde dehydrogenase family
N7297_06645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N7297_06645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N7297_06660	COG1981	membrane
N7297_06705	COG0456	acetyltransferase
N7297_06715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N7297_06720	COG0492	ferredoxin-NADP+ reductase activity
N7297_06725	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N7297_06725	COG1674	ftsk spoiiie
N7297_06730	COG1280	lysine exporter protein (LysE YggA)
N7297_06755	COG2894	cell division
N7297_06770	COG0204	Acyl-transferase
N7297_06775	COG2885	chlorophyll binding
N7297_06780	COG0210	DNA helicase
N7297_06790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N7297_06805	COG0121	glutamine amidotransferase
N7297_06825	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N7297_06830	COG0735	belongs to the Fur family
N7297_06855	COG0420	3'-5' exonuclease activity
N7297_06875	COG1090	epimerase
N7297_06890	COG2050	protein possibly involved in aromatic compounds catabolism
N7297_06900	COG2814	Major facilitator Superfamily
N7297_06905	COG0405	Gamma-glutamyltransferase
N7297_06980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N7297_07070	COG1484	DNA-dependent DNA replication
N7297_07265	COG2026	Addiction module toxin, RelE StbE family
N7297_07305	COG0592	DNA-directed DNA polymerase activity
N7297_07410	COG0582	viral genome integration into host DNA
N7297_07465	COG0629	single-stranded DNA binding
N7297_07500	COG0084	hydrolase, TatD family'
N7297_07520	COG0477	Major facilitator Superfamily
N7297_07525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N7297_07535	COG1595	DNA-templated transcription, initiation
N7297_07590	COG0531	amino acid
N7297_07595	COG2040	homocysteine
N7297_07620	COG1309	transcriptional regulator
N7297_07625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N7297_07630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N7297_07640	COG1607	acyl-coa hydrolase
N7297_07650	COG0523	cobalamin synthesis protein
N7297_07660	COG4681	YaeQ
N7297_07670	COG0726	polysaccharide deacetylase
N7297_07670	COG1649	PFAM Uncharacterised BCR, COG1649
N7297_07675	COG1215	transferase activity, transferring glycosyl groups
N7297_07685	COG1024	Enoyl-CoA hydratase
N7297_07700	COG1414	Transcriptional regulator
N7297_07720	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_07730	COG0446	pyridine nucleotide-disulphide oxidoreductase
N7297_07735	COG2271	Major facilitator Superfamily
N7297_07745	COG2267	carboxylic ester hydrolase activity
N7297_07750	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_07765	COG0028	Belongs to the TPP enzyme family
N7297_07775	COG0477	Major facilitator Superfamily
N7297_07780	COG0242	peptide deformylase activity
N7297_07785	COG2066	Belongs to the glutaminase family
N7297_07790	COG2207	Transcriptional regulator
N7297_07795	COG2223	nitrite transmembrane transporter activity
N7297_07810	COG0583	DNA-binding transcription factor activity
N7297_07815	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_07820	COG2271	Major facilitator Superfamily
N7297_07825	COG3959	Transketolase, thiamine diphosphate binding domain
N7297_07830	COG3958	Transketolase
N7297_07840	COG0306	phosphate transporter
N7297_07860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N7297_07905	COG4181	ATPase activity
N7297_07910	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N7297_07935	COG0583	DNA-binding transcription factor activity
N7297_07945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N7297_07950	COG1773	rubredoxin
N7297_08005	COG2851	Citrate transporter
N7297_08010	COG1253	flavin adenine dinucleotide binding
N7297_08050	COG0804	urea catabolic process
N7297_08060	COG0830	nickel cation binding
N7297_08075	COG0742	ribosomal rna small subunit methyltransferase
N7297_08080	COG0768	penicillin binding
N7297_08105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N7297_08110	COG2878	Part of a membrane complex involved in electron transport
N7297_08115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N7297_08125	COG3384	dioxygenase
N7297_08150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N7297_08480	COG0739	heme binding
N7297_08525	COG2194	sulfuric ester hydrolase activity
N7297_08565	COG0006	proline dipeptidase activity
N7297_08570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N7297_08575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N7297_08595	COG1279	arginine transmembrane transporter activity
N7297_08600	COG0583	DNA-binding transcription factor activity
N7297_08640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N7297_08645	COG0741	lytic transglycosylase activity
N7297_08645	COG1388	LysM domain
N7297_08645	COG0741	lytic transglycosylase activity
N7297_08645	COG1388	LysM domain
N7297_08655	COG4174	ABC transporter (Permease)
N7297_08660	COG4239	(ABC) transporter, permease
N7297_08665	COG4172	Belongs to the ABC transporter superfamily
N7297_08685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N7297_08695	COG2203	Gaf domain
N7297_08695	COG5001	Diguanylate cyclase
N7297_08695	COG3706	GGDEF domain
N7297_08695	COG4251	negative regulation of phosphorylation
N7297_08705	COG1902	pentaerythritol trinitrate reductase activity
N7297_08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
N7297_08725	COG1309	transcriptional regulator
N7297_08730	COG1741	Belongs to the pirin family
N7297_08745	COG2072	flavoprotein involved in K transport
N7297_08755	COG2252	PERMEase
N7297_08760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N7297_08765	COG3038	cytochrome b561
N7297_08775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N7297_08785	COG0527	aspartate kinase activity
N7297_08795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N7297_08805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N7297_08820	COG0667	Aldo Keto reductase
N7297_08840	COG1765	OsmC-like protein
N7297_08855	COG0542	response to heat
N7297_08890	COG2885	chlorophyll binding
N7297_08900	COG0625	glutathione transferase activity
N7297_08905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N7297_08925	COG3634	alkyl hydroperoxide reductase activity
N7297_08935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N7297_08945	COG0450	alkyl hydroperoxide reductase
N7297_08950	COG1643	Atp-dependent helicase
N7297_08965	COG2814	Major facilitator Superfamily
N7297_08970	COG3135	benzoate transporter
N7297_08975	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_08980	COG0543	2 iron, 2 sulfur cluster binding
N7297_08980	COG0633	Ferredoxin
N7297_08985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N7297_08990	COG4638	Rieske (2fe-2S)
N7297_09000	COG0583	DNA-binding transcription factor activity
N7297_09050	COG1570	exodeoxyribonuclease VII activity
N7297_09080	COG1280	lysine exporter protein (LysE YggA)
N7297_09085	COG1278	Cold shock
N7297_09120	COG2814	Major facilitator Superfamily
N7297_09155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N7297_09155	COG0517	IMP dehydrogenase activity
N7297_09160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N7297_09170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N7297_09175	COG1137	ATPase activity
N7297_09180	COG1538	Outer membrane efflux protein
N7297_09210	COG4122	O-methyltransferase activity
N7297_09220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N7297_09235	COG1522	sequence-specific DNA binding
N7297_09240	COG5006	permease, DMT superfamily
N7297_09250	COG1560	Kdo2-lipid A biosynthetic process
N7297_09265	COG2814	Major facilitator Superfamily
N7297_09285	COG1250	3-hydroxyacyl-CoA dehydrogenase
N7297_09335	COG0583	DNA-binding transcription factor activity
N7297_09340	COG1914	H( )-stimulated, divalent metal cation uptake system
N7297_09360	COG4770	biotin carboxylase activity
N7297_09365	COG0038	chloride channel
N7297_09385	COG1309	transcriptional regulator
N7297_09395	COG1063	alcohol dehydrogenase
N7297_09410	COG0439	Biotin carboxylase
N7297_09415	COG2249	NAD(P)H dehydrogenase (quinone) activity
N7297_09435	COG0864	Transcriptional regulator
N7297_09445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N7297_09450	COG1116	anion transmembrane transporter activity
N7297_09570	COG0590	tRNA wobble adenosine to inosine editing
N7297_09575	COG2807	transmembrane transport
N7297_09590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N7297_09605	COG0789	Transcriptional regulator
N7297_09615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N7297_09635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N7297_09645	COG0446	pyridine nucleotide-disulphide oxidoreductase
N7297_09660	COG1012	belongs to the aldehyde dehydrogenase family
N7297_09665	COG0531	amino acid
N7297_09670	COG1760	l-serine dehydratase
N7297_09675	COG2030	dehydratase
N7297_09675	COG1012	belongs to the aldehyde dehydrogenase family
N7297_09680	COG3396	Phenylacetate-CoA oxygenase
N7297_09685	COG3460	Phenylacetate-CoA oxygenase
N7297_09690	COG3396	Phenylacetate-CoA oxygenase
N7297_09695	COG2151	metal-sulfur cluster biosynthetic enzyme
N7297_09700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N7297_09705	COG1024	Enoyl-CoA hydratase
N7297_09710	COG1024	Enoyl-CoA hydratase
N7297_09715	COG1250	3-hydroxyacyl-CoA dehydrogenase
N7297_09720	COG0183	Belongs to the thiolase family
N7297_09725	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
N7297_09730	COG3327	negative regulation of DNA-templated transcription, initiation
N7297_09740	COG2050	protein possibly involved in aromatic compounds catabolism
N7297_09775	COG0753	catalase activity
N7297_09780	COG3038	cytochrome b561
N7297_09800	COG2267	carboxylic ester hydrolase activity
N7297_09805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N7297_09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N7297_09815	COG1012	belongs to the aldehyde dehydrogenase family
N7297_09825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N7297_09835	COG1012	belongs to the aldehyde dehydrogenase family
N7297_09840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N7297_09845	COG0583	DNA-binding transcription factor activity
N7297_09855	COG1414	Transcriptional regulator
N7297_09860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N7297_09870	COG1840	ABC-type Fe3 transport system, periplasmic component
N7297_09875	COG3842	ATPase activity
N7297_09890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N7297_09895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N7297_09900	COG2814	Major facilitator Superfamily
N7297_09905	COG1960	acyl-CoA dehydrogenase activity
N7297_09920	COG1024	Enoyl-CoA hydratase
N7297_09930	COG2814	Major facilitator Superfamily
N7297_09940	COG0183	Belongs to the thiolase family
N7297_09945	COG1250	3-hydroxyacyl-CoA dehydrogenase
N7297_09950	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_09955	COG1024	Enoyl-CoA hydratase
N7297_09960	COG1960	acyl-CoA dehydrogenase activity
N7297_09965	COG2814	Major facilitator Superfamily
N7297_09970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N7297_09975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N7297_09985	COG2814	Major facilitator Superfamily
N7297_09995	COG1960	acyl-CoA dehydrogenase activity
N7297_10010	COG0583	DNA-binding transcription factor activity
N7297_10020	COG4770	biotin carboxylase activity
N7297_10025	COG1024	Enoyl-CoA hydratase
N7297_10030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N7297_10035	COG1960	acyl-CoA dehydrogenase activity
N7297_10040	COG1309	transcriptional regulator
N7297_10045	COG0318	PFAM AMP-dependent synthetase and ligase
N7297_10065	COG0583	DNA-binding transcription factor activity
N7297_10115	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_10135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N7297_10155	COG2205	protein histidine kinase activity
N7297_10155	COG0784	Response regulator, receiver
N7297_10175	COG0765	amino acid transport
N7297_10180	COG0765	amino acid transport
N7297_10185	COG1126	abc transporter atp-binding protein
N7297_10190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N7297_10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N7297_10210	COG1280	lysine exporter protein (LysE YggA)
N7297_10225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N7297_10230	COG1045	serine acetyltransferase
N7297_10245	COG0583	DNA-binding transcription factor activity
N7297_10250	COG0625	glutathione transferase activity
N7297_10255	COG0625	glutathione transferase activity
N7297_10260	COG0583	DNA-binding transcription factor activity
N7297_10270	COG1346	cytolysis
N7297_10290	COG2814	Major facilitator Superfamily
N7297_10300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N7297_10305	COG3052	prosthetic group binding
N7297_10325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N7297_10345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N7297_10355	COG1294	oxidase, subunit
N7297_10360	COG1271	oxidase subunit
N7297_10380	COG0477	Major facilitator Superfamily
N7297_10400	COG4521	taurine ABC transporter
N7297_10405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N7297_10410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N7297_10415	COG2175	clavaminate synthase activity
N7297_10425	COG1953	Uracil, thiamine, allantoin
N7297_10435	COG0583	DNA-binding transcription factor activity
N7297_10445	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
N7297_10460	COG0640	Transcriptional regulator
N7297_10465	COG0798	PFAM Bile acid sodium symporter
N7297_10470	COG0583	DNA-binding transcription factor activity
N7297_10485	COG3634	alkyl hydroperoxide reductase activity
N7297_10525	COG0436	Aminotransferase
N7297_10535	COG0386	Belongs to the glutathione peroxidase family
N7297_10575	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N7297_10600	COG0012	GTP binding
N7297_10605	COG2011	ABC-type metal ion transport system permease component
N7297_10610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N7297_10620	COG1464	Belongs to the NlpA lipoprotein family
N7297_10650	COG0765	amino acid transport
N7297_10655	COG0765	amino acid transport
N7297_10660	COG1126	abc transporter atp-binding protein
N7297_10670	COG1522	sequence-specific DNA binding
N7297_10685	COG1309	transcriptional regulator
N7297_10705	COG0583	DNA-binding transcription factor activity
N7297_10715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N7297_10725	COG0697	spore germination
N7297_10750	COG3121	Chaperone
N7297_10755	COG3539	Fimbrial protein
N7297_10780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N7297_10780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N7297_10825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N7297_10835	COG2353	YceI-like domain
N7297_10845	COG3698	Phosphodiester glycosidase
N7297_10860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N7297_10865	COG0506	proline dehydrogenase activity
N7297_10865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N7297_10865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N7297_10875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N7297_10880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N7297_10900	COG1132	(ABC) transporter
N7297_10905	COG3122	Protein conserved in bacteria
N7297_10910	COG3619	membrane
N7297_10925	COG0640	Transcriptional regulator
N7297_10935	COG2850	peptidyl-arginine hydroxylation
N7297_10940	COG0424	maF-like protein
N7297_10960	COG0191	fructose-bisphosphate aldolase activity
N7297_10965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N7297_10980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N7297_10990	COG1192	Involved in chromosome partitioning
N7297_10995	COG1475	DNA binding
N7297_11000	COG0811	peptide transport
N7297_11010	COG1132	(ABC) transporter
N7297_11015	COG1663	tetraacyldisaccharide 4'-kinase activity
N7297_11035	COG0084	hydrolase, TatD family'
N7297_11100	COG0776	regulation of translation
N7297_11130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N7297_11135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N7297_11185	COG0339	signal peptide processing
N7297_11195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N7297_11230	COG0702	epimerase
N7297_11235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N7297_11255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N7297_11285	COG0316	Belongs to the HesB IscA family
N7297_11290	COG0822	iron-sulfur transferase activity
N7297_11315	COG0776	regulation of translation
N7297_11320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N7297_11325	COG2207	Transcriptional regulator
N7297_11330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N7297_11335	COG1960	acyl-CoA dehydrogenase activity
N7297_11340	COG1960	acyl-CoA dehydrogenase activity
N7297_11355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N7297_11375	COG4264	IucA IucC family
N7297_11380	COG4264	IucA IucC family
N7297_11420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N7297_11435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
N7297_11455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N7297_11460	COG0730	response to heat
N7297_11480	COG4773	Receptor
N7297_11485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N7297_11500	COG1131	(ABC) transporter
N7297_11505	COG0842	Transport permease protein
N7297_11510	COG0842	Transport permease protein
N7297_11565	COG2226	methyltransferase
N7297_11590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N7297_11625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N7297_11635	COG0133	tryptophan synthase activity
N7297_11650	COG3706	GGDEF domain
N7297_11665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N7297_11670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N7297_11675	COG0022	dehydrogenase e1 component
N7297_11680	COG0508	dehydrogenase complex catalyzes the overall conversion of
N7297_11685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N7297_11695	COG1063	alcohol dehydrogenase
N7297_11700	COG3781	membrane
N7297_11710	COG3453	Protein conserved in bacteria
N7297_11710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N7297_11725	COG0730	response to heat
N7297_11740	COG2207	Transcriptional regulator
N7297_11740	COG3708	Transcriptional regulator
N7297_11745	COG1733	regulation of RNA biosynthetic process
N7297_11750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N7297_11760	COG2188	Transcriptional regulator
N7297_11775	COG4521	taurine ABC transporter
N7297_11780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N7297_11800	COG0477	Major facilitator Superfamily
N7297_11810	COG1027	Aspartate ammonia-lyase
N7297_11825	COG0583	DNA-binding transcription factor activity
N7297_11830	COG0583	DNA-binding transcription factor activity
N7297_11835	COG0183	Belongs to the thiolase family
N7297_11840	COG2031	fatty acid transporter
N7297_11845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N7297_11855	COG0583	DNA-binding transcription factor activity
N7297_11865	COG2610	gluconate transmembrane transporter activity
N7297_11870	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_11880	COG2207	Transcriptional regulator
N7297_11895	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_11920	COG0543	2 iron, 2 sulfur cluster binding
N7297_11920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N7297_11925	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N7297_11930	COG4638	Rieske (2fe-2S)
N7297_11940	COG0725	ABC transporter, periplasmic molybdate-binding protein
N7297_11945	COG4149	molybdate abc transporter
N7297_11950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N7297_11955	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_11960	COG3433	isochorismatase activity
N7297_11960	COG1535	isochorismatase
N7297_12020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N7297_12035	COG0753	catalase activity
N7297_12045	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N7297_12075	COG3539	Fimbrial protein
N7297_12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N7297_12115	COG2072	flavoprotein involved in K transport
N7297_12125	COG1538	Outer membrane efflux protein
N7297_12130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N7297_12135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7297_12140	COG0745	RESPONSE REGULATOR receiver
N7297_12145	COG2205	protein histidine kinase activity
N7297_12155	COG2207	Transcriptional regulator
N7297_12170	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_12220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N7297_12340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N7297_12360	COG1120	ATPase activity
N7297_12365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7297_12375	COG1064	alcohol dehydrogenase
N7297_12390	COG2207	Transcriptional regulator
N7297_12395	COG2084	Dehydrogenase
N7297_12405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N7297_12410	COG0583	DNA-binding transcription factor activity
N7297_12420	COG0129	dihydroxy-acid dehydratase activity
N7297_12425	COG1012	belongs to the aldehyde dehydrogenase family
N7297_12440	COG1566	PFAM secretion protein HlyD family protein
N7297_12470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N7297_12500	COG0583	DNA-binding transcription factor activity
N7297_12515	COG2188	Transcriptional regulator
N7297_12545	COG3210	domain, Protein
N7297_12550	COG2831	hemolysin activation secretion protein
N7297_12560	COG1473	amidohydrolase
N7297_12570	COG0475	glutathione-regulated potassium exporter activity
N7297_12570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N7297_12580	COG0583	DNA-binding transcription factor activity
N7297_12585	COG1335	isochorismatase
N7297_12595	COG1309	transcriptional regulator
N7297_12625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N7297_12635	COG0446	pyridine nucleotide-disulphide oxidoreductase
N7297_12635	COG1902	pentaerythritol trinitrate reductase activity
N7297_12640	COG1846	Transcriptional regulator
N7297_12660	COG0753	catalase activity
N7297_12675	COG1012	belongs to the aldehyde dehydrogenase family
N7297_12690	COG3162	membrane
N7297_12700	COG3829	transcription factor binding
N7297_12705	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_12710	COG1960	acyl-CoA dehydrogenase activity
N7297_12730	COG1012	belongs to the aldehyde dehydrogenase family
N7297_12750	COG2186	Transcriptional regulator
N7297_12760	COG0583	DNA-binding transcription factor activity
N7297_12765	COG4948	Mandelate Racemase Muconate Lactonizing
N7297_12770	COG4829	muconolactone delta-isomerase
N7297_12780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N7297_12785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N7297_12790	COG0183	Belongs to the thiolase family
N7297_12795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N7297_12805	COG1012	belongs to the aldehyde dehydrogenase family
N7297_12815	COG3733	amine oxidase
N7297_12825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N7297_12835	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_12845	COG4638	Rieske (2fe-2S)
N7297_12865	COG0154	amidase activity
N7297_12875	COG2814	Major facilitator Superfamily
N7297_12900	COG1960	acyl-CoA dehydrogenase activity
N7297_12905	COG0583	DNA-binding transcription factor activity
N7297_12910	COG1414	Transcriptional regulator
N7297_12925	COG2391	methyltransferase activity
N7297_12935	COG4993	Dehydrogenase
N7297_12940	COG3659	wide pore channel activity
N7297_12945	COG3420	alginic acid biosynthetic process
N7297_12950	COG0710	3-dehydroquinate dehydratase activity
N7297_12955	COG3485	protocatechuate 3,4-dioxygenase
N7297_12960	COG3485	protocatechuate 3,4-dioxygenase
N7297_12965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N7297_12970	COG2271	Major facilitator Superfamily
N7297_12975	COG0596	Alpha beta hydrolase
N7297_12980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N7297_12985	COG0183	Belongs to the thiolase family
N7297_12990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N7297_12995	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N7297_13005	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N7297_13010	COG2323	membrane
N7297_13055	COG1902	pentaerythritol trinitrate reductase activity
N7297_13055	COG0446	pyridine nucleotide-disulphide oxidoreductase
N7297_13080	COG0542	response to heat
N7297_13085	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N7297_13115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N7297_13120	COG0569	domain protein
N7297_13125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N7297_13140	COG4774	siderophore transport
N7297_13145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N7297_13155	COG1585	Membrane protein implicated in regulation of membrane protease activity
N7297_13170	COG1294	oxidase, subunit
N7297_13175	COG4890	Cyd operon protein YbgT
N7297_13190	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N7297_13200	COG0552	protein localization to endoplasmic reticulum
N7297_13225	COG0517	IMP dehydrogenase activity
N7297_13225	COG0516	GMP reductase activity
N7297_13230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N7297_13235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N7297_13245	COG0583	DNA-binding transcription factor activity
N7297_13250	COG0024	Methionine aminopeptidase
N7297_13280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N7297_13280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7297_13285	COG1105	Belongs to the carbohydrate kinase PfkB family
N7297_13290	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N7297_13290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N7297_13290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N7297_13310	COG3300	MHYT domain
N7297_13310	COG5001	Diguanylate cyclase
N7297_13325	COG2135	peptidase activity
N7297_13330	COG0659	secondary active sulfate transmembrane transporter activity
N7297_13350	COG1113	amino acid transport
N7297_13360	COG1522	sequence-specific DNA binding
N7297_13385	COG1011	Hydrolase
N7297_13390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N7297_13400	COG2137	regulation of response to DNA damage stimulus
N7297_13415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N7297_13450	COG0575	Belongs to the CDS family
N7297_13455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N7297_13475	COG3852	Histidine kinase
N7297_13480	COG2204	response regulator
N7297_13535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N7297_13540	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N7297_13560	COG0697	spore germination
N7297_13565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N7297_13575	COG0303	'Molybdopterin
N7297_13580	COG0315	cyclic pyranopterin monophosphate synthase activity
N7297_13580	COG0521	Mo-molybdopterin cofactor biosynthetic process
N7297_13595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N7297_13600	COG0243	molybdopterin cofactor binding
N7297_13610	COG0243	molybdopterin cofactor binding
N7297_13615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N7297_13620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N7297_13620	COG2146	nitrite reductase [NAD(P)H] activity
N7297_13630	COG0745	RESPONSE REGULATOR receiver
N7297_13635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N7297_13635	COG1116	anion transmembrane transporter activity
N7297_13655	COG0511	ligase activity, forming carbon-carbon bonds
N7297_13670	COG2814	Major facilitator Superfamily
N7297_13735	COG0739	heme binding
N7297_13860	COG5410	chromosome segregation
N7297_14025	COG0069	glutamate synthase activity
N7297_14045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N7297_14055	COG1454	alcohol dehydrogenase
N7297_14060	COG0824	Thioesterase
N7297_14070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N7297_14085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N7297_14090	COG2030	dehydratase
N7297_14100	COG0183	Belongs to the thiolase family
N7297_14110	COG0583	DNA-binding transcription factor activity
N7297_14115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N7297_14125	COG1522	sequence-specific DNA binding
N7297_14130	COG3135	benzoate transporter
N7297_14140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N7297_14165	COG0589	response to stress
N7297_14170	COG0488	(ABC) transporter
N7297_14190	COG4773	Receptor
N7297_14225	COG0668	transmembrane transport
N7297_14235	COG1309	transcriptional regulator
N7297_14255	COG1605	Chorismate mutase
N7297_14285	COG0308	aminopeptidase N
N7297_14305	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
N7297_14315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N7297_14320	COG1454	alcohol dehydrogenase
N7297_14340	COG0531	amino acid
N7297_14345	COG4303	Ethanolamine ammonia lyase large subunit
N7297_14350	COG4302	ethanolamine ammonia-lyase activity
N7297_14355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N7297_14355	COG0519	Catalyzes the synthesis of GMP from XMP
N7297_14360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N7297_14370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N7297_14385	COG0697	spore germination
N7297_14390	COG1923	regulation of RNA biosynthetic process
N7297_14400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N7297_14405	COG0802	atpase or kinase
N7297_14425	COG1187	pseudouridine synthase activity
N7297_14440	COG0583	DNA-binding transcription factor activity
N7297_14455	COG2814	Major facilitator Superfamily
N7297_14460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N7297_14485	COG0729	surface antigen
N7297_14505	COG0174	glutamine synthetase
N7297_14510	COG0745	RESPONSE REGULATOR receiver
N7297_14515	COG2205	protein histidine kinase activity
N7297_14525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N7297_14530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N7297_14555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N7297_14560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N7297_14565	COG1960	acyl-CoA dehydrogenase activity
N7297_14580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N7297_14585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N7297_14605	COG0583	DNA-binding transcription factor activity
N7297_14620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N7297_14630	COG3658	cytochrome
N7297_14635	COG1215	transferase activity, transferring glycosyl groups
N7297_14640	COG1649	PFAM Uncharacterised BCR, COG1649
N7297_14640	COG0726	polysaccharide deacetylase
N7297_14665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N7297_14670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N7297_14680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N7297_14705	COG0305	Participates in initiation and elongation during chromosome replication
N7297_14710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N7297_14720	COG1305	Transglutaminase-like
N7297_14730	COG2308	Evidence 4 Homologs of previously reported genes of
N7297_14760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N7297_14765	COG0138	bifunctional purine biosynthesis protein purh
N7297_14770	COG0151	Belongs to the GarS family
N7297_14775	COG1464	Belongs to the NlpA lipoprotein family
N7297_14780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N7297_14785	COG2011	ABC-type metal ion transport system permease component
N7297_14790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N7297_14800	COG1301	dicarboxylic acid transport
N7297_14840	COG2433	Pfam Transposase IS66
N7297_14850	COG3173	Aminoglycoside phosphotransferase
N7297_14855	COG0488	(ABC) transporter
N7297_14885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N7297_14885	COG3008	intermembrane lipid transfer
N7297_14890	COG2995	paraquat-inducible protein a
N7297_14900	COG2985	domain, Protein
N7297_14930	COG0477	Major facilitator Superfamily
N7297_14980	COG2186	Transcriptional regulator
N7297_14990	COG0786	glutamate:sodium symporter activity
N7297_14995	COG3243	poly(R)-hydroxyalkanoic acid synthase
N7297_15020	COG3111	PFAM Bacterial OB fold (BOF) protein
N7297_15120	COG1610	YqeY-like protein
N7297_15125	COG4783	chaperone-mediated protein folding
N7297_15150	COG1286	toxin biosynthetic process
N7297_15180	COG0778	Nitroreductase
N7297_15190	COG0513	Belongs to the DEAD box helicase family
N7297_15215	COG2363	Small membrane protein
N7297_15245	COG1234	tRNA 3'-trailer cleavage
N7297_15250	COG2195	Cleaves the N-terminal amino acid of tripeptides
N7297_15260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N7297_15270	COG2819	hydrolase of the alpha beta superfamily
N7297_15275	COG1960	acyl-CoA dehydrogenase activity
N7297_15280	COG1301	dicarboxylic acid transport
N7297_15285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N7297_15290	COG3139	Protein of unknown function (DUF1315)
N7297_15295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N7297_15300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N7297_15310	COG0494	nUDIX hydrolase
N7297_15320	COG0642	Histidine kinase
N7297_15335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N7297_15345	COG1720	tRNA m6t6A37 methyltransferase activity
N7297_15360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N7297_15365	COG0826	peptidase U32
N7297_15370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N7297_15380	COG4598	ABC transporter
N7297_15385	COG4160	amino acid transport
N7297_15390	COG4215	(ABC) transporter
N7297_15405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7297_15450	COG1131	(ABC) transporter
N7297_15455	COG0842	Transport permease protein
N7297_15470	COG0772	Belongs to the SEDS family
N7297_15475	COG2951	lytic endotransglycosylase activity
N7297_15500	COG2207	Transcriptional regulator
N7297_15515	COG0052	Belongs to the universal ribosomal protein uS2 family
N7297_15520	COG0024	Methionine aminopeptidase
N7297_15530	COG2223	nitrite transmembrane transporter activity
N7297_15540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N7297_15545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N7297_15550	COG1960	acyl-CoA dehydrogenase activity
N7297_15565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N7297_15570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N7297_15575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N7297_15595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N7297_15600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N7297_15605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N7297_15640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N7297_15650	COG0174	glutamine synthetase
N7297_15665	COG0512	Glutamine amidotransferase of anthranilate synthase
N7297_15670	COG0308	aminopeptidase N
N7297_15700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N7297_15710	COG0302	gtp cyclohydrolase
N7297_15735	COG3739	integral membrane protein
N7297_15750	COG1169	isochorismate synthase
N7297_15760	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
N7297_15765	COG1132	(ABC) transporter
N7297_15770	COG1132	(ABC) transporter
N7297_15785	COG3433	isochorismatase activity
N7297_15785	COG1535	isochorismatase
N7297_15790	COG1021	2,3-dihydroxybenzoate-AMP ligase
N7297_15795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N7297_15805	COG4774	siderophore transport
N7297_15810	COG4607	ABC-type enterochelin transport system periplasmic component
N7297_15815	COG4604	ABC transporter, ATP-binding protein
N7297_15820	COG4605	iron ion homeostasis
N7297_15825	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7297_15835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N7297_15850	COG2964	Protein conserved in bacteria
N7297_15860	COG1741	Belongs to the pirin family
N7297_15880	COG1309	transcriptional regulator
N7297_15890	COG4948	Mandelate Racemase Muconate Lactonizing
N7297_15895	COG2814	Major facilitator Superfamily
N7297_15930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N7297_15930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N7297_15935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N7297_15945	COG1012	belongs to the aldehyde dehydrogenase family
N7297_15955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N7297_15960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N7297_15965	COG0583	DNA-binding transcription factor activity
N7297_15970	COG1113	amino acid transport
N7297_15990	COG2508	Transcriptional regulator
N7297_15990	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
N7297_16025	COG2879	small protein
N7297_16030	COG1966	Carbon starvation protein
N7297_16075	COG1067	ATP-dependent peptidase activity
N7297_16080	COG0583	DNA-binding transcription factor activity
N7297_16105	COG1686	Belongs to the peptidase S11 family
N7297_16110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N7297_16140	COG3328	transposase activity
N7297_16155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N7297_16165	COG0573	inorganic phosphate transmembrane transporter activity
N7297_16170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N7297_16175	COG1113	amino acid transport
N7297_16180	COG3961	Belongs to the TPP enzyme family
N7297_16185	COG1522	sequence-specific DNA binding
N7297_16195	COG0076	glutamate decarboxylase activity
N7297_16200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N7297_16210	COG1309	transcriptional regulator
N7297_16225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N7297_16260	COG0352	thiamine-phosphate diphosphorylase activity
N7297_16285	COG0612	Peptidase, M16
N7297_16295	COG1823	symporter activity
N7297_16300	COG0583	DNA-binding transcription factor activity
N7297_16305	COG0477	Major facilitator Superfamily
N7297_16330	COG1187	pseudouridine synthase activity
N7297_16345	COG1686	Belongs to the peptidase S11 family
N7297_16350	COG1252	NADH dehydrogenase
N7297_16360	COG0415	Belongs to the DNA photolyase family
N7297_16375	COG1215	transferase activity, transferring glycosyl groups
N7297_16405	COG2070	2-Nitropropane dioxygenase
N7297_16460	COG0556	nucleotide-excision repair
N7297_16480	COG0436	Aminotransferase
N7297_16510	COG4221	oxidoreductase activity
N7297_16520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N7297_16525	COG1381	Involved in DNA repair and RecF pathway recombination
N7297_16535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N7297_16550	COG0681	Belongs to the peptidase S26 family
N7297_16565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N7297_16585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N7297_16590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N7297_16595	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N7297_16605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N7297_16610	COG4208	sulfate ABC transporter
N7297_16615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N7297_16620	COG0583	DNA-binding transcription factor activity
N7297_16625	COG4625	pathogenesis
N7297_16640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N7297_16655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N7297_16665	COG1051	belongs to the nudix hydrolase family
N7297_16665	COG1056	cytidyltransferase-related domain
N7297_16670	COG1024	Enoyl-CoA hydratase
N7297_16685	COG2814	Major facilitator Superfamily
N7297_16690	COG0047	phosphoribosylformylglycinamidine synthase activity
N7297_16690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N7297_16710	COG1473	amidohydrolase
N7297_16715	COG0824	Thioesterase
N7297_16735	COG0823	Involved in the tonB-independent uptake of proteins
N7297_16755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N7297_16790	COG0628	permease
N7297_16800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N7297_16805	COG0596	Alpha beta hydrolase
N7297_16810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N7297_16810	COG0616	signal peptide processing
N7297_16820	COG2333	competence protein COMEC
N7297_16820	COG0658	competence protein
N7297_16825	COG1136	(ABC) transporter
N7297_16830	COG4591	ABC-type transport system involved in lipoprotein release permease component
N7297_16865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7297_16885	COG0463	Glycosyl transferase, family 2
N7297_16915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N7297_16920	COG1280	lysine exporter protein (LysE YggA)
N7297_16930	COG0019	diaminopimelate decarboxylase activity
N7297_16940	COG1113	amino acid transport
N7297_16955	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N7297_16965	COG3339	Conserved Protein
N7297_16970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N7297_16975	COG0243	molybdopterin cofactor binding
N7297_16980	COG1929	Belongs to the glycerate kinase type-1 family
N7297_16995	COG0778	Nitroreductase
N7297_17025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N7297_17040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N7297_17060	COG0741	lytic transglycosylase activity
N7297_17080	COG0584	glycerophosphoryl diester phosphodiesterase
N7297_17110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N7297_17115	COG1597	lipid kinase activity
N7297_17130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N7297_17135	COG0477	Major facilitator Superfamily
N7297_17185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N7297_17190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N7297_17215	COG0505	Belongs to the CarA family
N7297_17235	COG0589	response to stress
N7297_17250	COG2843	Capsule synthesis protein
N7297_17270	COG2321	neutral zinc metallopeptidase
N7297_17275	COG2354	Protein conserved in bacteria
N7297_17295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N7297_17320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N7297_17325	COG1053	succinate dehydrogenase
N7297_17330	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N7297_17335	COG2009	succinate dehydrogenase
N7297_17375	COG2921	Belongs to the UPF0250 family
N7297_17380	COG0321	lipoyl(octanoyl) transferase activity
N7297_17395	COG0531	amino acid
N7297_17405	COG1733	regulation of RNA biosynthetic process
N7297_17410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N7297_17415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N7297_17415	COG1648	precorrin-2 dehydrogenase activity
N7297_17430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N7297_17460	COG0671	phosphoesterase, PA-phosphatase related
N7297_17465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7297_17475	COG1538	Outer membrane efflux protein
N7297_17480	COG0393	Putative heavy-metal-binding
N7297_17485	COG0393	Putative heavy-metal-binding
N7297_17495	COG1028	Short-chain dehydrogenase reductase Sdr
N7297_17505	COG0525	valine-tRNA ligase activity
N7297_17525	COG0583	DNA-binding transcription factor activity
N7297_17530	COG0004	ammonium transporteR
N7297_17540	COG0642	Histidine kinase
N7297_17545	COG0745	RESPONSE REGULATOR receiver
N7297_17550	COG2194	sulfuric ester hydrolase activity
N7297_17570	COG1752	Esterase of the alpha-beta hydrolase superfamily
N7297_17585	COG2315	Protein conserved in bacteria
N7297_17590	COG0142	geranyltranstransferase activity
N7297_17595	COG2828	Protein conserved in bacteria
N7297_17600	COG1113	amino acid transport
N7297_17620	COG2207	Transcriptional regulator
N7297_17645	COG2249	NAD(P)H dehydrogenase (quinone) activity
N7297_17655	COG0560	Phosphoserine phosphatase
N7297_17665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N7297_17675	COG1530	ribonuclease E activity
N7297_17680	COG0424	maF-like protein
N7297_17685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N7297_17690	COG1792	Involved in formation and maintenance of cell shape
N7297_17695	COG1077	Cell shape determining protein MreB Mrl
N7297_17700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N7297_17710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N7297_17750	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
N7297_17755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N7297_17760	COG1752	Esterase of the alpha-beta hydrolase superfamily
N7297_17765	COG1115	amino acid carrier protein
N7297_17785	COG2814	Major facilitator Superfamily
N7297_17790	COG1289	transmembrane transporter activity
N7297_17800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N7297_17840	COG1376	ErfK ybiS ycfS ynhG family protein
N7297_17845	COG2832	Protein of unknown function (DUF454)
N7297_17855	COG5510	response to toxic substance
N7297_17875	COG0840	transmembrane signaling receptor activity
N7297_17915	COG3422	double-strand break repair
N7297_17920	COG2824	Alkylphosphonate utilization operon protein PhnA
N7297_17925	COG3189	MarR family transcriptional regulator
N7297_17935	COG0354	folic acid binding
N7297_17940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7297_17950	COG0679	Auxin Efflux Carrier
N7297_17955	COG1902	pentaerythritol trinitrate reductase activity
N7297_17975	COG2094	Belongs to the DNA glycosylase MPG family
N7297_18000	COG1217	gtp-binding protein TYPA
N7297_18005	COG2233	PERMEase
N7297_18015	COG0833	amino acid
N7297_18020	COG1690	Belongs to the RtcB family
N7297_18030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N7297_18030	COG2885	chlorophyll binding
N7297_18040	COG0183	Belongs to the thiolase family
N7297_18060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N7297_18080	COG2207	Transcriptional regulator
N7297_18085	COG0183	Belongs to the thiolase family
N7297_18115	COG1272	protein, Hemolysin III
N7297_18120	COG0477	Major facilitator Superfamily
N7297_18135	COG0450	alkyl hydroperoxide reductase
N7297_18155	COG0285	dihydrofolate synthase activity
N7297_18205	COG2096	Adenosyltransferase
N7297_18225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N7297_18230	COG0745	RESPONSE REGULATOR receiver
N7297_18235	COG2205	protein histidine kinase activity
N7297_18245	COG1960	acyl-CoA dehydrogenase activity
N7297_18250	COG1960	acyl-CoA dehydrogenase activity
N7297_18255	COG0583	DNA-binding transcription factor activity
N7297_18260	COG0625	glutathione transferase activity
N7297_18325	COG0438	transferase activity, transferring glycosyl groups
N7297_18330	COG0463	Glycosyl transferase, family 2
N7297_18335	COG0726	polysaccharide deacetylase
N7297_18355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N7297_18360	COG2205	protein histidine kinase activity
N7297_18390	COG1862	Preprotein translocase
N7297_18400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N7297_18405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N7297_18415	COG3781	membrane
N7297_18420	COG0613	PHP domain protein
N7297_18430	COG2350	Protein conserved in bacteria
N7297_18460	COG1607	acyl-coa hydrolase
N7297_18520	COG2199	diguanylate cyclase activity
N7297_18530	COG1408	metallophosphoesterase
N7297_18535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N7297_18545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N7297_18565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N7297_18570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N7297_18585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N7297_18595	COG2969	positive regulation of protein catabolic process
N7297_18615	COG1960	acyl-CoA dehydrogenase activity
N7297_18620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N7297_18635	COG1309	transcriptional regulator
N7297_18640	COG1960	acyl-CoA dehydrogenase activity
N7297_18695	COG0741	lytic transglycosylase activity
N7297_18730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7297_18900	COG1525	nuclease
N7297_18965	COG1475	DNA binding
N7297_18980	COG3853	Toxic anion resistance protein (TelA)
N7297_19075	COG0484	heat shock protein binding