locus-tag	class	description
ACIAD0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACIAD0002	COG0592	DNA-directed DNA polymerase activity
ACIAD0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIAD0004	COG0187	DNA topoisomerase II activity
ACIAD0007	COG0488	(ABC) transporter
ACIAD0010	COG0316	Belongs to the HesB IscA family
ACIAD0011	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ACIAD0013	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACIAD0015	COG0737	Belongs to the 5'-nucleotidase family
ACIAD0020	COG1047	Peptidyl-prolyl cis-trans
ACIAD0021	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIAD0022	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACIAD0023	COG0196	riboflavin kinase activity
ACIAD0025	COG0596	Alpha beta hydrolase
ACIAD0026	COG1309	transcriptional regulator
ACIAD0027	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD0028	COG1335	isochorismatase
ACIAD0029	COG0251	oxidation-reduction process
ACIAD0030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD0031	COG2233	PERMEase
ACIAD0034	COG1116	anion transmembrane transporter activity
ACIAD0035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD0036	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD0037	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD0038	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD0039	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIAD0039	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACIAD0042	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD0043	COG0546	phosphoglycolate phosphatase activity
ACIAD0044	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACIAD0048	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD0048	COG1017	nitric oxide dioxygenase activity
ACIAD0050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACIAD0063	COG3023	N-Acetylmuramoyl-L-alanine amidase
ACIAD0072	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACIAD0076	COG1088	dTDP-glucose 4,6-dehydratase activity
ACIAD0078	COG1091	dTDP-4-dehydrorhamnose reductase activity
ACIAD0081	COG0438	transferase activity, transferring glycosyl groups
ACIAD0087	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACIAD0088	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIAD0091	COG0438	transferase activity, transferring glycosyl groups
ACIAD0092	COG0438	transferase activity, transferring glycosyl groups
ACIAD0093	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACIAD0095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACIAD0099	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACIAD0101	COG0166	Belongs to the GPI family
ACIAD0102	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACIAD0103	COG3307	-O-antigen
ACIAD0104	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIAD0105	COG0583	DNA-binding transcription factor activity
ACIAD0106	COG1620	l-lactate permease
ACIAD0107	COG2186	Transcriptional regulator
ACIAD0108	COG1304	FMN binding
ACIAD0109	COG0277	FAD linked oxidase domain protein
ACIAD0112	COG1448	Aminotransferase
ACIAD0114	COG1522	sequence-specific DNA binding
ACIAD0115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIAD0117	COG0251	oxidation-reduction process
ACIAD0118	COG1113	amino acid transport
ACIAD0120	COG3121	Chaperone
ACIAD0121	COG3188	usher protein
ACIAD0123	COG3121	Chaperone
ACIAD0126	COG2721	sulfolactate sulfo-lyase activity
ACIAD0127	COG2271	Major facilitator Superfamily
ACIAD0128	COG4948	Mandelate Racemase Muconate Lactonizing
ACIAD0130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIAD0131	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD0132	COG2186	Transcriptional regulator
ACIAD0133	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIAD0135	COG1609	Transcriptional regulator
ACIAD0136	COG2233	PERMEase
ACIAD0137	COG0402	S-adenosylhomocysteine deaminase activity
ACIAD0142	COG0271	Belongs to the BolA IbaG family
ACIAD0144	COG1192	Involved in chromosome partitioning
ACIAD0148	COG0586	Pfam SNARE associated Golgi protein
ACIAD0149	COG2259	Doxx family
ACIAD0150	COG3111	PFAM Bacterial OB fold (BOF) protein
ACIAD0151	COG0519	Catalyzes the synthesis of GMP from XMP
ACIAD0151	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACIAD0164	COG0018	arginyl-trna synthetase
ACIAD0166	COG0281	malic enzyme
ACIAD0167	COG3501	Rhs element vgr protein
ACIAD0168	COG5632	N-Acetylmuramoyl-L-alanine amidase
ACIAD0168	COG3409	Peptidoglycan-binding domain 1 protein
ACIAD0168	COG1388	LysM domain
ACIAD0172	COG2837	iron assimilation
ACIAD0173	COG1280	lysine exporter protein (LysE YggA)
ACIAD0174	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACIAD0175	COG1121	(ABC) transporter
ACIAD0180	COG0356	it plays a direct role in the translocation of protons across the membrane
ACIAD0183	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACIAD0184	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIAD0185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACIAD0186	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACIAD0187	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACIAD0188	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACIAD0193	COG0386	Belongs to the glutathione peroxidase family
ACIAD0196	COG1309	transcriptional regulator
ACIAD0197	COG0697	spore germination
ACIAD0208	COG0009	L-threonylcarbamoyladenylate synthase
ACIAD0209	COG0758	DNA mediated transformation
ACIAD0210	COG1652	LysM domain
ACIAD0217	COG1309	transcriptional regulator
ACIAD0223	COG0477	Major facilitator Superfamily
ACIAD0225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIAD0226	COG3757	hydrolase, family 25
ACIAD0230	COG1253	flavin adenine dinucleotide binding
ACIAD0232	COG2860	membrane
ACIAD0233	COG0477	Major facilitator Superfamily
ACIAD0235	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD0239	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACIAD0242	COG0606	chelatase, subunit chli
ACIAD0244	COG0347	Belongs to the P(II) protein family
ACIAD0245	COG0004	ammonium transporteR
ACIAD0246	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACIAD0247	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIAD0247	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIAD0253	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACIAD0255	COG0795	lipopolysaccharide-transporting ATPase activity
ACIAD0256	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACIAD0257	COG0793	Belongs to the peptidase S41A family
ACIAD0260	COG2197	response regulator
ACIAD0263	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACIAD0266	COG4974	Belongs to the 'phage' integrase family
ACIAD0270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACIAD0271	COG0772	Belongs to the SEDS family
ACIAD0272	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIAD0273	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACIAD0275	COG0494	nUDIX hydrolase
ACIAD0276	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACIAD0278	COG1538	Outer membrane efflux protein
ACIAD0282	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACIAD0283	COG0165	Argininosuccinate lyase
ACIAD0284	COG3275	phosphorelay sensor kinase activity
ACIAD0286	COG0181	hydroxymethylbilane synthase activity
ACIAD0290	COG0824	Thioesterase
ACIAD0299	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIAD0302	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACIAD0304	COG0081	regulation of translation
ACIAD0305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACIAD0306	COG0222	ribosome binding
ACIAD0307	COG0085	RNA polymerase activity
ACIAD0308	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACIAD0313	COG2056	Na+-H+ antiporter family
ACIAD0316	COG0326	Molecular chaperone. Has ATPase activity
ACIAD0318	COG1794	racemase activity, acting on amino acids and derivatives
ACIAD0319	COG1301	dicarboxylic acid transport
ACIAD0321	COG2801	Transposase and inactivated derivatives
ACIAD0323	COG0583	DNA-binding transcription factor activity
ACIAD0331	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACIAD0334	COG0183	Belongs to the thiolase family
ACIAD0335	COG1024	Enoyl-CoA hydratase
ACIAD0335	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACIAD0340	COG0322	excinuclease ABC activity
ACIAD0342	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIAD0344	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIAD0344	COG2169	Transcriptional regulator
ACIAD0351	COG1566	PFAM secretion protein HlyD family protein
ACIAD0352	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACIAD0353	COG1678	Uncharacterized ACR, COG1678
ACIAD0354	COG0497	DNA recombination
ACIAD0356	COG3123	guanosine phosphorylase activity
ACIAD0357	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIAD0359	COG0237	dephospho-CoA kinase activity
ACIAD0363	COG0149	triose-phosphate isomerase activity
ACIAD0367	COG0779	Required for maturation of 30S ribosomal subunits
ACIAD0368	COG0195	Participates in both transcription termination and antitermination
ACIAD0369	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACIAD0370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACIAD0372	COG2212	antiporter activity
ACIAD0374	COG0651	ATP synthesis coupled electron transport
ACIAD0375	COG1006	Multisubunit Na H antiporter MnhC subunit
ACIAD0376	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIAD0376	COG2111	Na H antiporter
ACIAD0378	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIAD0380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACIAD0382	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACIAD0384	COG2226	methyltransferase
ACIAD0388	COG3121	Chaperone
ACIAD0389	COG3188	usher protein
ACIAD0397	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ACIAD0398	COG1074	ATP-dependent DNA helicase activity
ACIAD0399	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIAD0401	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACIAD0402	COG1185	polyribonucleotide nucleotidyltransferase activity
ACIAD0403	COG0598	Magnesium transport protein CorA
ACIAD0404	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACIAD0405	COG0789	Transcriptional regulator
ACIAD0407	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACIAD0409	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACIAD0415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACIAD0416	COG4535	Mg2 and Co2 transporter CorC
ACIAD0418	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACIAD0419	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACIAD0421	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIAD0421	COG0493	'glutamate synthase
ACIAD0425	COG0254	rRNA binding
ACIAD0426	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACIAD0429	COG0534	Mate efflux family protein
ACIAD0432	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACIAD0434	COG0583	DNA-binding transcription factor activity
ACIAD0436	COG0450	alkyl hydroperoxide reductase
ACIAD0437	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD0438	COG1530	ribonuclease E activity
ACIAD0443	COG0546	phosphoglycolate phosphatase activity
ACIAD0445	COG0625	glutathione transferase activity
ACIAD0448	COG0583	DNA-binding transcription factor activity
ACIAD0451	COG0753	catalase activity
ACIAD0452	COG1960	acyl-CoA dehydrogenase activity
ACIAD0455	COG0494	nUDIX hydrolase
ACIAD0461	COG0583	DNA-binding transcription factor activity
ACIAD0463	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACIAD0466	COG0066	3-isopropylmalate dehydratase activity
ACIAD0469	COG0473	3-isopropylmalate dehydrogenase activity
ACIAD0472	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACIAD0474	COG0101	tRNA pseudouridine synthase activity
ACIAD0481	COG1301	dicarboxylic acid transport
ACIAD0484	COG1560	Kdo2-lipid A biosynthetic process
ACIAD0485	COG0405	Gamma-glutamyltransferase
ACIAD0486	COG1280	lysine exporter protein (LysE YggA)
ACIAD0495	COG0210	DNA helicase
ACIAD0500	COG4651	solute:proton antiporter activity
ACIAD0500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIAD0501	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACIAD0502	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACIAD0505	COG0788	formyltetrahydrofolate deformylase activity
ACIAD0515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACIAD0518	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACIAD0522	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIAD0526	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACIAD0528	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD0528	COG2813	Specifically methylates the guanine in position
ACIAD0529	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD0530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIAD0531	COG3128	pkhd-type hydroxylase
ACIAD0532	COG4774	siderophore transport
ACIAD0533	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACIAD0534	COG0740	serine-type endopeptidase activity
ACIAD0535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACIAD0538	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACIAD0538	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACIAD0540	COG0280	phosphate acetyltransferase
ACIAD0540	COG0857	belongs to the CobB CobQ family
ACIAD0541	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACIAD0543	COG0800	Aldolase
ACIAD0545	COG3265	gluconokinase activity
ACIAD0546	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD0547	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACIAD0552	COG0793	Belongs to the peptidase S41A family
ACIAD0556	COG0105	UTP biosynthetic process
ACIAD0557	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACIAD0560	COG1426	Protein conserved in bacteria
ACIAD0561	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACIAD0562	COG0124	histidyl-tRNA synthetase
ACIAD0568	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIAD0569	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIAD0571	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIAD0574	COG2986	histidine ammonia-lyase
ACIAD0580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIAD0582	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD0583	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIAD0589	COG1862	Preprotein translocase
ACIAD0590	COG0343	queuine tRNA-ribosyltransferase activity
ACIAD0591	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACIAD0595	COG5002	protein histidine kinase activity
ACIAD0596	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACIAD0600	COG0726	polysaccharide deacetylase
ACIAD0601	COG0463	Glycosyl transferase, family 2
ACIAD0602	COG0438	transferase activity, transferring glycosyl groups
ACIAD0609	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACIAD0621	COG3223	Belongs to the PsiE family
ACIAD0623	COG1960	acyl-CoA dehydrogenase activity
ACIAD0624	COG1960	acyl-CoA dehydrogenase activity
ACIAD0626	COG2205	protein histidine kinase activity
ACIAD0627	COG0745	RESPONSE REGULATOR receiver
ACIAD0628	COG2315	Protein conserved in bacteria
ACIAD0633	COG2096	Adenosyltransferase
ACIAD0634	COG4206	TonB-dependent receptor
ACIAD0636	COG0133	tryptophan synthase activity
ACIAD0642	COG0159	tryptophan synthase activity
ACIAD0643	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACIAD0644	COG0285	dihydrofolate synthase activity
ACIAD0647	COG0450	alkyl hydroperoxide reductase
ACIAD0648	COG0653	protein targeting
ACIAD0650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACIAD0651	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACIAD0654	COG2199	diguanylate cyclase activity
ACIAD0660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACIAD0661	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACIAD0663	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACIAD0664	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIAD0674	COG0494	nUDIX hydrolase
ACIAD0677	COG1214	PFAM Peptidase M22, glycoprotease
ACIAD0678	COG1968	undecaprenyl-diphosphatase activity
ACIAD0679	COG0742	ribosomal rna small subunit methyltransferase
ACIAD0685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACIAD0687	COG2132	Multicopper oxidase
ACIAD0692	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIAD0694	COG0183	Belongs to the thiolase family
ACIAD0697	COG2885	chlorophyll binding
ACIAD0697	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ACIAD0700	COG0833	amino acid
ACIAD0701	COG2813	Specifically methylates the guanine in position
ACIAD0702	COG2233	PERMEase
ACIAD0704	COG1970	mechanosensitive ion channel activity
ACIAD0706	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIAD0707	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIAD0708	COG4772	TonB-dependent receptor
ACIAD0709	COG1902	pentaerythritol trinitrate reductase activity
ACIAD0713	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACIAD0714	COG0354	folic acid binding
ACIAD0715	COG0564	pseudouridine synthase activity
ACIAD0719	COG2824	Alkylphosphonate utilization operon protein PhnA
ACIAD0721	COG3422	double-strand break repair
ACIAD0722	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIAD0726	COG0745	RESPONSE REGULATOR receiver
ACIAD0727	COG2205	protein histidine kinase activity
ACIAD0730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD0731	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD0733	COG0649	NAD binding
ACIAD0733	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD0735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACIAD0737	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACIAD0738	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD0740	COG0713	ATP synthesis coupled electron transport
ACIAD0741	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIAD0742	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD0744	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACIAD0746	COG0583	DNA-binding transcription factor activity
ACIAD0750	COG0668	transmembrane transport
ACIAD0752	COG2081	HI0933 family
ACIAD0753	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ACIAD0758	COG2226	methyltransferase
ACIAD0759	COG1280	lysine exporter protein (LysE YggA)
ACIAD0762	COG2233	PERMEase
ACIAD0768	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIAD0768	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIAD0769	COG3248	Nucleoside-binding outer membrane protein
ACIAD0772	COG0489	protein tyrosine kinase activity
ACIAD0773	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACIAD0776	COG0717	Belongs to the dCTP deaminase family
ACIAD0782	COG0442	prolyl-tRNA aminoacylation
ACIAD0789	COG0840	transmembrane signaling receptor activity
ACIAD0790	COG2198	Histidine kinase
ACIAD0790	COG0643	Histidine kinase
ACIAD0791	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACIAD0794	COG2832	Protein of unknown function (DUF454)
ACIAD0795	COG1376	ErfK ybiS ycfS ynhG family protein
ACIAD0801	COG1289	transmembrane transporter activity
ACIAD0802	COG2814	Major facilitator Superfamily
ACIAD0804	COG0786	glutamate:sodium symporter activity
ACIAD0805	COG1115	amino acid carrier protein
ACIAD0806	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIAD0808	COG0693	protein deglycase activity
ACIAD0809	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ACIAD0822	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIAD0823	COG0154	amidase activity
ACIAD0824	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIAD0825	COG1077	Cell shape determining protein MreB Mrl
ACIAD0826	COG1792	Involved in formation and maintenance of cell shape
ACIAD0828	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ACIAD0829	COG0424	maF-like protein
ACIAD0830	COG1530	ribonuclease E activity
ACIAD0832	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD0834	COG0560	Phosphoserine phosphatase
ACIAD0837	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIAD0839	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACIAD0840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACIAD0842	COG0730	response to heat
ACIAD0846	COG1196	nuclear chromosome segregation
ACIAD0848	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIAD0854	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIAD0855	COG2226	methyltransferase
ACIAD0855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD0855	COG0596	Alpha beta hydrolase
ACIAD0858	COG4106	trans-aconitate 2-methyltransferase activity
ACIAD0862	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACIAD0863	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACIAD0865	COG0009	L-threonylcarbamoyladenylate synthase
ACIAD0866	COG3101	peptidyl-lysine hydroxylation
ACIAD0868	COG1399	metal-binding, possibly nucleic acid-binding protein
ACIAD0869	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACIAD0871	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD0872	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIAD0873	COG1652	LysM domain
ACIAD0875	COG0351	phosphomethylpyrimidine kinase
ACIAD0875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACIAD0875	COG0352	thiamine-phosphate diphosphorylase activity
ACIAD0877	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIAD0877	COG2755	lipolytic protein G-D-S-L family
ACIAD0881	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACIAD0883	COG0049	tRNA binding
ACIAD0884	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACIAD0885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIAD0888	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACIAD0889	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACIAD0890	COG0492	ferredoxin-NADP+ reductase activity
ACIAD0891	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACIAD0891	COG1674	ftsk spoiiie
ACIAD0893	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ACIAD0895	COG0850	regulation of cytokinetic process
ACIAD0897	COG0204	Acyl-transferase
ACIAD0898	COG2885	chlorophyll binding
ACIAD0900	COG0210	DNA helicase
ACIAD0901	COG0756	dUTP diphosphatase activity
ACIAD0903	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIAD0905	COG0121	glutamine amidotransferase
ACIAD0908	COG2914	Belongs to the UPF0125 (RnfH) family
ACIAD0909	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIAD0910	COG0735	belongs to the Fur family
ACIAD0914	COG1968	undecaprenyl-diphosphatase activity
ACIAD0917	COG0420	3'-5' exonuclease activity
ACIAD0921	COG1090	epimerase
ACIAD0924	COG2050	protein possibly involved in aromatic compounds catabolism
ACIAD0926	COG1566	PFAM secretion protein HlyD family protein
ACIAD0927	COG2814	Major facilitator Superfamily
ACIAD0929	COG0405	Gamma-glutamyltransferase
ACIAD0930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACIAD0933	COG3220	belongs to the UPF0276 family
ACIAD0935	COG1595	DNA-templated transcription, initiation
ACIAD0939	COG2831	hemolysin activation secretion protein
ACIAD0940	COG3210	domain, Protein
ACIAD0952	COG2801	Transposase and inactivated derivatives
ACIAD0957	COG2801	Transposase and inactivated derivatives
ACIAD0960	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD0964	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIAD0967	COG0583	DNA-binding transcription factor activity
ACIAD0969	COG1120	ATPase activity
ACIAD0970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACIAD0979	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD0984	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD0985	COG1414	Transcriptional regulator
ACIAD0986	COG2146	nitrite reductase [NAD(P)H] activity
ACIAD0989	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD0991	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD0992	COG2271	Major facilitator Superfamily
ACIAD0994	COG2267	carboxylic ester hydrolase activity
ACIAD0995	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD0997	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ACIAD0998	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD0999	COG0028	Belongs to the TPP enzyme family
ACIAD1007	COG0579	oxidoreductase
ACIAD1008	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ACIAD1009	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD1010	COG1309	transcriptional regulator
ACIAD1011	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACIAD1012	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACIAD1015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIAD1017	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACIAD1018	COG0022	dehydrogenase e1 component
ACIAD1019	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIAD1020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD1021	COG1063	alcohol dehydrogenase
ACIAD1023	COG1607	acyl-coa hydrolase
ACIAD1025	COG0523	cobalamin synthesis protein
ACIAD1027	COG4681	YaeQ
ACIAD1029	COG1649	PFAM Uncharacterised BCR, COG1649
ACIAD1029	COG0726	polysaccharide deacetylase
ACIAD1030	COG1215	transferase activity, transferring glycosyl groups
ACIAD1035	COG0400	carboxylic ester hydrolase activity
ACIAD1038	COG0561	phosphatase activity
ACIAD1039	COG0242	peptide deformylase activity
ACIAD1040	COG2066	Belongs to the glutaminase family
ACIAD1042	COG2223	nitrite transmembrane transporter activity
ACIAD1047	COG0306	phosphate transporter
ACIAD1048	COG3048	D-serine ammonia-lyase activity
ACIAD1052	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACIAD1054	COG4771	TonB-dependent receptor
ACIAD1056	COG0288	reversible hydration of carbon dioxide
ACIAD1058	COG4181	ATPase activity
ACIAD1059	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ACIAD1060	COG0705	Rhomboid family
ACIAD1060	COG0457	Tetratricopeptide repeat
ACIAD1061	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACIAD1063	COG0583	DNA-binding transcription factor activity
ACIAD1065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD1066	COG1773	rubredoxin
ACIAD1069	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACIAD1070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIAD1071	COG1492	cobalamin metabolic process
ACIAD1072	COG0175	sulfate reduction
ACIAD1074	COG2851	Citrate transporter
ACIAD1081	COG1253	flavin adenine dinucleotide binding
ACIAD1088	COG0829	nickel cation binding
ACIAD1089	COG0831	urea catabolic process
ACIAD1090	COG0832	Belongs to the urease beta subunit family
ACIAD1091	COG0804	urea catabolic process
ACIAD1093	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ACIAD1094	COG0830	nickel cation binding
ACIAD1095	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACIAD1100	COG0742	ribosomal rna small subunit methyltransferase
ACIAD1101	COG0768	penicillin binding
ACIAD1105	COG0563	adenylate kinase activity
ACIAD1108	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACIAD1109	COG2878	Part of a membrane complex involved in electron transport
ACIAD1110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACIAD1112	COG3384	dioxygenase
ACIAD1113	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACIAD1116	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACIAD1119	COG0463	Glycosyl transferase, family 2
ACIAD1123	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACIAD1126	COG0006	proline dipeptidase activity
ACIAD1127	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD1128	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD1132	COG0792	nuclease activity
ACIAD1137	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACIAD1138	COG1388	LysM domain
ACIAD1138	COG0741	lytic transglycosylase activity
ACIAD1138	COG1388	LysM domain
ACIAD1138	COG0741	lytic transglycosylase activity
ACIAD1139	COG4166	transmembrane transport
ACIAD1140	COG4174	ABC transporter (Permease)
ACIAD1141	COG4239	(ABC) transporter, permease
ACIAD1142	COG4172	Belongs to the ABC transporter superfamily
ACIAD1147	COG0833	amino acid
ACIAD1149	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACIAD1150	COG0418	dihydroorotase activity
ACIAD1152	COG0583	DNA-binding transcription factor activity
ACIAD1154	COG0697	spore germination
ACIAD1155	COG1902	pentaerythritol trinitrate reductase activity
ACIAD1155	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD1160	COG1538	Outer membrane efflux protein
ACIAD1161	COG1595	DNA-templated transcription, initiation
ACIAD1163	COG4774	siderophore transport
ACIAD1165	COG2771	luxR family
ACIAD1168	COG1113	amino acid transport
ACIAD1178	COG1215	transferase activity, transferring glycosyl groups
ACIAD1182	COG0415	Belongs to the DNA photolyase family
ACIAD1184	COG1686	Belongs to the peptidase S11 family
ACIAD1188	COG2351	hydroxyisourate hydrolase activity
ACIAD1193	COG0038	chloride channel
ACIAD1194	COG0612	Peptidase, M16
ACIAD1201	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACIAD1202	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ACIAD1205	COG0783	Belongs to the Dps family
ACIAD1207	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD1210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACIAD1211	COG0076	glutamate decarboxylase activity
ACIAD1212	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIAD1213	COG0573	inorganic phosphate transmembrane transporter activity
ACIAD1215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACIAD1216	COG0616	signal peptide processing
ACIAD1220	COG2915	High frequency lysogenization protein hflD homolog
ACIAD1221	COG0482	sulfurtransferase activity
ACIAD1224	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ACIAD1225	COG1686	Belongs to the peptidase S11 family
ACIAD1227	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACIAD1230	COG0583	DNA-binding transcription factor activity
ACIAD1231	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIAD1234	COG3634	alkyl hydroperoxide reductase activity
ACIAD1238	COG0589	response to stress
ACIAD1241	COG0659	secondary active sulfate transmembrane transporter activity
ACIAD1243	COG2252	PERMEase
ACIAD1245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACIAD1246	COG3038	cytochrome b561
ACIAD1248	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACIAD1249	COG2801	Transposase and inactivated derivatives
ACIAD1251	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACIAD1252	COG0527	aspartate kinase activity
ACIAD1253	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACIAD1257	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACIAD1258	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACIAD1261	COG0667	Aldo Keto reductase
ACIAD1263	COG1765	OsmC-like protein
ACIAD1266	COG0129	dihydroxy-acid dehydratase activity
ACIAD1268	COG0116	Belongs to the methyltransferase superfamily
ACIAD1268	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACIAD1270	COG0540	Belongs to the ATCase OTCase family
ACIAD1274	COG4106	trans-aconitate 2-methyltransferase activity
ACIAD1276	COG0531	amino acid
ACIAD1279	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIAD1279	COG0189	ligase activity
ACIAD1284	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIAD1286	COG3138	arginine N-succinyltransferase
ACIAD1287	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD1288	COG3724	N-succinylarginine dihydrolase activity
ACIAD1289	COG2988	succinylglutamate desuccinylase activity
ACIAD1293	COG0235	Class ii aldolase
ACIAD1297	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACIAD1298	COG1126	abc transporter atp-binding protein
ACIAD1301	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIAD1302	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACIAD1308	COG2022	thiamine diphosphate biosynthetic process
ACIAD1310	COG2363	Small membrane protein
ACIAD1314	COG0513	Belongs to the DEAD box helicase family
ACIAD1317	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACIAD1321	COG0167	dihydroorotate dehydrogenase activity
ACIAD1328	COG4783	chaperone-mediated protein folding
ACIAD1331	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACIAD1332	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACIAD1336	COG0515	serine threonine protein kinase
ACIAD1336	COG2815	serine threonine protein kinase
ACIAD1339	COG1301	dicarboxylic acid transport
ACIAD1343	COG1113	amino acid transport
ACIAD1344	COG1522	sequence-specific DNA binding
ACIAD1346	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIAD1347	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACIAD1348	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIAD1349	COG1585	Membrane protein implicated in regulation of membrane protease activity
ACIAD1351	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIAD1355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACIAD1356	COG0569	domain protein
ACIAD1357	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACIAD1358	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACIAD1360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACIAD1362	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACIAD1363	COG0542	response to heat
ACIAD1364	COG1742	UPF0060 membrane protein
ACIAD1365	COG0657	acetylesterase activity
ACIAD1365	COG2755	lipolytic protein G-D-S-L family
ACIAD1366	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACIAD1369	COG3852	Histidine kinase
ACIAD1371	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIAD1372	COG0528	UMP kinase activity
ACIAD1373	COG0233	cytoplasmic translational termination
ACIAD1374	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIAD1375	COG0575	Belongs to the CDS family
ACIAD1376	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACIAD1378	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIAD1380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIAD1381	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIAD1382	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIAD1384	COG2137	regulation of response to DNA damage stimulus
ACIAD1385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACIAD1386	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACIAD1389	COG0268	Binds directly to 16S ribosomal RNA
ACIAD1391	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACIAD1395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACIAD1398	COG0633	Ferredoxin
ACIAD1399	COG0443	Heat shock 70 kDa protein
ACIAD1400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACIAD1402	COG0316	Belongs to the HesB IscA family
ACIAD1403	COG0822	iron-sulfur transferase activity
ACIAD1408	COG0776	regulation of translation
ACIAD1409	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIAD1410	COG2207	Transcriptional regulator
ACIAD1411	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIAD1412	COG1960	acyl-CoA dehydrogenase activity
ACIAD1417	COG0531	amino acid
ACIAD1418	COG2040	homocysteine
ACIAD1419	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACIAD1421	COG0642	Histidine kinase
ACIAD1422	COG0745	RESPONSE REGULATOR receiver
ACIAD1423	COG2194	sulfuric ester hydrolase activity
ACIAD1431	COG3284	Transcriptional regulator
ACIAD1434	COG2814	Major facilitator Superfamily
ACIAD1435	COG0583	DNA-binding transcription factor activity
ACIAD1436	COG4638	Rieske (2fe-2S)
ACIAD1437	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACIAD1438	COG0633	Ferredoxin
ACIAD1438	COG0543	2 iron, 2 sulfur cluster binding
ACIAD1439	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD1440	COG3135	benzoate transporter
ACIAD1442	COG3485	protocatechuate 3,4-dioxygenase
ACIAD1443	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIAD1444	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACIAD1445	COG0583	DNA-binding transcription factor activity
ACIAD1446	COG4948	Mandelate Racemase Muconate Lactonizing
ACIAD1447	COG4829	muconolactone delta-isomerase
ACIAD1448	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACIAD1449	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACIAD1450	COG0183	Belongs to the thiolase family
ACIAD1451	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD1452	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACIAD1453	COG1733	regulation of RNA biosynthetic process
ACIAD1454	COG0604	alcohol dehydrogenase
ACIAD1458	COG0531	amino acid
ACIAD1461	COG3781	membrane
ACIAD1462	COG2186	Transcriptional regulator
ACIAD1463	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD1464	COG1116	anion transmembrane transporter activity
ACIAD1465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD1469	COG1595	DNA-templated transcription, initiation
ACIAD1481	COG0215	cysteine-tRNA ligase activity
ACIAD1482	COG0517	IMP dehydrogenase activity
ACIAD1482	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACIAD1483	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACIAD1485	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ACIAD1486	COG1137	ATPase activity
ACIAD1488	COG2274	protein secretion by the type I secretion system
ACIAD1498	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACIAD1500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACIAD1507	COG0601	transmembrane transport
ACIAD1508	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACIAD1514	COG1132	(ABC) transporter
ACIAD1515	COG1132	(ABC) transporter
ACIAD1516	COG4206	TonB-dependent receptor
ACIAD1518	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD1521	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIAD1524	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD1525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD1526	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD1527	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD1531	COG0747	negative chemotaxis
ACIAD1535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD1537	COG1053	succinate dehydrogenase
ACIAD1539	COG0583	DNA-binding transcription factor activity
ACIAD1559	COG1846	Transcriptional regulator
ACIAD1561	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD1568	COG1024	Enoyl-CoA hydratase
ACIAD1569	COG0183	Belongs to the thiolase family
ACIAD1571	COG1024	Enoyl-CoA hydratase
ACIAD1572	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD1577	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD1582	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACIAD1583	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIAD1584	COG1045	serine acetyltransferase
ACIAD1586	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD1592	COG2175	clavaminate synthase activity
ACIAD1596	COG0667	Aldo Keto reductase
ACIAD1599	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIAD1600	COG2175	clavaminate synthase activity
ACIAD1602	COG0583	DNA-binding transcription factor activity
ACIAD1606	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIAD1607	COG1960	acyl-CoA dehydrogenase activity
ACIAD1608	COG1024	Enoyl-CoA hydratase
ACIAD1611	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIAD1612	COG0183	Belongs to the thiolase family
ACIAD1613	COG1960	acyl-CoA dehydrogenase activity
ACIAD1624	COG3604	Transcriptional regulator
ACIAD1625	COG0730	response to heat
ACIAD1630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIAD1632	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIAD1633	COG0642	Histidine kinase
ACIAD1638	COG1396	sequence-specific DNA binding
ACIAD1640	COG2885	chlorophyll binding
ACIAD1640	COG3047	cAMP biosynthetic process
ACIAD1642	COG1968	undecaprenyl-diphosphatase activity
ACIAD1645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIAD1646	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACIAD1646	COG0506	proline dehydrogenase activity
ACIAD1646	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACIAD1649	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIAD1650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACIAD1651	COG0477	Major facilitator Superfamily
ACIAD1652	COG0596	Alpha beta hydrolase
ACIAD1654	COG1902	pentaerythritol trinitrate reductase activity
ACIAD1654	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD1656	COG0583	DNA-binding transcription factor activity
ACIAD1657	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIAD1659	COG0583	DNA-binding transcription factor activity
ACIAD1660	COG1960	acyl-CoA dehydrogenase activity
ACIAD1662	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACIAD1664	COG4589	Belongs to the CDS family
ACIAD1667	COG2453	phosphatase
ACIAD1667	COG0671	phosphoesterase, PA-phosphatase related
ACIAD1668	COG2267	carboxylic ester hydrolase activity
ACIAD1669	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIAD1672	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACIAD1674	COG1380	Effector of murein hydrolase LrgA
ACIAD1675	COG0583	DNA-binding transcription factor activity
ACIAD1680	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACIAD1680	COG0644	oxidoreductase
ACIAD1681	COG2814	Major facilitator Superfamily
ACIAD1685	COG2814	Major facilitator Superfamily
ACIAD1689	COG0183	Belongs to the thiolase family
ACIAD1690	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACIAD1691	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD1692	COG1024	Enoyl-CoA hydratase
ACIAD1693	COG1960	acyl-CoA dehydrogenase activity
ACIAD1694	COG2814	Major facilitator Superfamily
ACIAD1696	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACIAD1698	COG2814	Major facilitator Superfamily
ACIAD1700	COG1960	acyl-CoA dehydrogenase activity
ACIAD1701	COG1024	Enoyl-CoA hydratase
ACIAD1702	COG1414	Transcriptional regulator
ACIAD1704	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACIAD1705	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACIAD1706	COG0183	Belongs to the thiolase family
ACIAD1707	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACIAD1708	COG0596	Alpha beta hydrolase
ACIAD1709	COG2271	Major facilitator Superfamily
ACIAD1710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACIAD1711	COG3485	protocatechuate 3,4-dioxygenase
ACIAD1712	COG3485	protocatechuate 3,4-dioxygenase
ACIAD1713	COG0710	3-dehydroquinate dehydratase activity
ACIAD1714	COG3420	alginic acid biosynthetic process
ACIAD1715	COG3659	wide pore channel activity
ACIAD1716	COG4993	Dehydrogenase
ACIAD1718	COG1414	Transcriptional regulator
ACIAD1719	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD1723	COG1960	acyl-CoA dehydrogenase activity
ACIAD1726	COG1024	Enoyl-CoA hydratase
ACIAD1727	COG2814	Major facilitator Superfamily
ACIAD1729	COG1309	transcriptional regulator
ACIAD1733	COG2072	flavoprotein involved in K transport
ACIAD1734	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACIAD1736	COG0439	Biotin carboxylase
ACIAD1738	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACIAD1740	COG1469	GTP cyclohydrolase I activity
ACIAD1741	COG0523	cobalamin synthesis protein
ACIAD1743	COG0604	alcohol dehydrogenase
ACIAD1743	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD1743	COG3321	synthase
ACIAD1744	COG1027	Aspartate ammonia-lyase
ACIAD1745	COG0583	DNA-binding transcription factor activity
ACIAD1749	COG1294	oxidase, subunit
ACIAD1750	COG1271	oxidase subunit
ACIAD1754	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ACIAD1755	COG3052	prosthetic group binding
ACIAD1763	COG1045	serine acetyltransferase
ACIAD1764	COG4774	siderophore transport
ACIAD1769	COG0410	ABC transporter
ACIAD1773	COG2223	nitrite transmembrane transporter activity
ACIAD1774	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACIAD1778	COG1595	DNA-templated transcription, initiation
ACIAD1788	COG3501	Rhs element vgr protein
ACIAD1791	COG2801	Transposase and inactivated derivatives
ACIAD1798	COG2755	lipolytic protein G-D-S-L family
ACIAD1798	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIAD1800	COG2116	formate transmembrane transporter activity
ACIAD1808	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD1812	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACIAD1815	COG2814	Major facilitator Superfamily
ACIAD1816	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACIAD1820	COG1024	Enoyl-CoA hydratase
ACIAD1821	COG1960	acyl-CoA dehydrogenase activity
ACIAD1824	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD1826	COG0045	succinate-CoA ligase (ADP-forming) activity
ACIAD1826	COG1042	CoA-binding domain protein
ACIAD1826	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACIAD1827	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD1828	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD1829	COG1024	Enoyl-CoA hydratase
ACIAD1830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD1832	COG4628	conserved protein (DUF2132)
ACIAD1834	COG2207	Transcriptional regulator
ACIAD1835	COG1073	alpha beta
ACIAD1836	COG1902	pentaerythritol trinitrate reductase activity
ACIAD1838	COG2207	Transcriptional regulator
ACIAD1840	COG2207	Transcriptional regulator
ACIAD1865	COG0640	Transcriptional regulator
ACIAD1866	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACIAD1868	COG3122	Protein conserved in bacteria
ACIAD1869	COG0668	transmembrane transport
ACIAD1873	COG1132	(ABC) transporter
ACIAD1876	COG0509	glycine decarboxylation via glycine cleavage system
ACIAD1878	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACIAD1879	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACIAD1881	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIAD1886	COG1960	acyl-CoA dehydrogenase activity
ACIAD1891	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACIAD1896	COG0697	spore germination
ACIAD1897	COG0436	Aminotransferase
ACIAD1899	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ACIAD1900	COG4149	molybdate abc transporter
ACIAD1901	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACIAD1902	COG0303	'Molybdopterin
ACIAD1903	COG0315	cyclic pyranopterin monophosphate synthase activity
ACIAD1903	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACIAD1908	COG0243	molybdopterin cofactor binding
ACIAD1909	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD1910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD1911	COG2223	nitrite transmembrane transporter activity
ACIAD1914	COG1116	anion transmembrane transporter activity
ACIAD1914	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD1915	COG0243	molybdopterin cofactor binding
ACIAD1916	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACIAD1920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIAD1923	COG0778	Nitroreductase
ACIAD1924	COG0697	spore germination
ACIAD1925	COG0191	fructose-bisphosphate aldolase activity
ACIAD1927	COG0126	phosphoglycerate kinase activity
ACIAD1930	COG0424	maF-like protein
ACIAD1931	COG2851	Citrate transporter
ACIAD1933	COG2850	peptidyl-arginine hydroxylation
ACIAD1934	COG0069	glutamate synthase activity
ACIAD1935	COG3829	transcription factor binding
ACIAD1945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACIAD1946	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIAD1948	COG1278	Cold shock
ACIAD1950	COG1454	alcohol dehydrogenase
ACIAD1951	COG0824	Thioesterase
ACIAD1960	COG1358	cellular component organization or biogenesis
ACIAD1969	COG4245	von Willebrand factor, type A
ACIAD1973	COG1309	transcriptional regulator
ACIAD1982	COG3135	benzoate transporter
ACIAD1984	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACIAD1986	COG1714	RDD family
ACIAD1987	COG0024	Methionine aminopeptidase
ACIAD1990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACIAD1990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACIAD1992	COG1105	Belongs to the carbohydrate kinase PfkB family
ACIAD1993	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ACIAD1993	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACIAD1993	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACIAD1996	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACIAD1999	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACIAD2001	COG0148	phosphopyruvate hydratase activity
ACIAD2002	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACIAD2003	COG0504	CTP synthase activity
ACIAD2005	COG0589	response to stress
ACIAD2008	COG0308	aminopeptidase N
ACIAD2011	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ACIAD2012	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ACIAD2014	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIAD2015	COG1454	alcohol dehydrogenase
ACIAD2019	COG0505	Belongs to the CarA family
ACIAD2028	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACIAD2032	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACIAD2034	COG2353	YceI-like domain
ACIAD2035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACIAD2037	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACIAD2041	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACIAD2042	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACIAD2042	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACIAD2045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACIAD2048	COG2193	ferroxidase activity
ACIAD2052	COG0217	transcriptional regulatory protein
ACIAD2056	COG1126	abc transporter atp-binding protein
ACIAD2058	COG0765	amino acid transport
ACIAD2059	COG0765	amino acid transport
ACIAD2068	COG1464	Belongs to the NlpA lipoprotein family
ACIAD2069	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACIAD2070	COG2011	ABC-type metal ion transport system permease component
ACIAD2071	COG0012	GTP binding
ACIAD2078	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACIAD2079	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACIAD2085	COG0386	Belongs to the glutathione peroxidase family
ACIAD2086	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIAD2087	COG0436	Aminotransferase
ACIAD2091	COG1045	serine acetyltransferase
ACIAD2096	COG3706	GGDEF domain
ACIAD2098	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACIAD2099	COG0596	Alpha beta hydrolase
ACIAD2102	COG1643	Atp-dependent helicase
ACIAD2103	COG0450	alkyl hydroperoxide reductase
ACIAD2120	COG4264	IucA IucC family
ACIAD2121	COG4264	IucA IucC family
ACIAD2124	COG4264	IucA IucC family
ACIAD2170	COG3561	AntA/AntB antirepressor
ACIAD2174	COG3567	Phage-associated protein, HI1409 family
ACIAD2175	COG5410	chromosome segregation
ACIAD2181	COG3093	addiction module antidote protein HigA
ACIAD2203	COG0714	Associated with various cellular activities
ACIAD2204	COG2879	small protein
ACIAD2205	COG1966	Carbon starvation protein
ACIAD2206	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACIAD2207	COG1509	lysine 2,3-aminomutase activity
ACIAD2210	COG0254	rRNA binding
ACIAD2216	COG1067	ATP-dependent peptidase activity
ACIAD2218	COG3022	response to hydroperoxide
ACIAD2220	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACIAD2222	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACIAD2225	COG0693	protein deglycase activity
ACIAD2226	COG1960	acyl-CoA dehydrogenase activity
ACIAD2227	COG1301	dicarboxylic acid transport
ACIAD2229	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIAD2230	COG3139	Protein of unknown function (DUF1315)
ACIAD2231	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACIAD2234	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACIAD2238	COG0642	Histidine kinase
ACIAD2239	COG0745	RESPONSE REGULATOR receiver
ACIAD2242	COG2203	Gaf domain
ACIAD2242	COG2199	diguanylate cyclase activity
ACIAD2243	COG1720	tRNA m6t6A37 methyltransferase activity
ACIAD2247	COG1953	Uracil, thiamine, allantoin
ACIAD2249	COG3384	dioxygenase
ACIAD2250	COG3634	alkyl hydroperoxide reductase activity
ACIAD2255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACIAD2259	COG1131	(ABC) transporter
ACIAD2260	COG0842	Transport permease protein
ACIAD2261	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACIAD2261	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACIAD2263	COG0772	Belongs to the SEDS family
ACIAD2264	COG2951	lytic endotransglycosylase activity
ACIAD2268	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACIAD2269	COG0052	Belongs to the universal ribosomal protein uS2 family
ACIAD2271	COG0024	Methionine aminopeptidase
ACIAD2274	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD2275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIAD2277	COG1960	acyl-CoA dehydrogenase activity
ACIAD2279	COG3706	GGDEF domain
ACIAD2280	COG0477	Major facilitator Superfamily
ACIAD2282	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACIAD2284	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACIAD2288	COG0617	tRNA 3'-terminal CCA addition
ACIAD2291	COG1294	oxidase, subunit
ACIAD2296	COG0552	protein localization to endoplasmic reticulum
ACIAD2298	COG0612	Peptidase, M16
ACIAD2305	COG4109	DRTGG domain
ACIAD2307	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIAD2309	COG3100	YcgL domain-containing protein
ACIAD2312	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACIAD2324	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIAD2325	COG4773	Receptor
ACIAD2329	COG0730	response to heat
ACIAD2330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACIAD2331	COG1253	flavin adenine dinucleotide binding
ACIAD2336	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACIAD2341	COG0284	orotidine-5'-phosphate decarboxylase activity
ACIAD2343	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACIAD2346	COG0776	regulation of translation
ACIAD2348	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACIAD2350	COG0590	tRNA wobble adenosine to inosine editing
ACIAD2352	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACIAD2354	COG3156	type II secretion system protein K
ACIAD2357	COG2165	general secretion pathway protein
ACIAD2359	COG0084	hydrolase, TatD family'
ACIAD2362	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACIAD2363	COG1663	tetraacyldisaccharide 4'-kinase activity
ACIAD2365	COG1132	(ABC) transporter
ACIAD2366	COG1475	DNA binding
ACIAD2367	COG1192	Involved in chromosome partitioning
ACIAD2368	COG0357	Ribosomal RNA small subunit methyltransferase G
ACIAD2369	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACIAD2371	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACIAD2372	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIAD2373	COG1923	regulation of RNA biosynthetic process
ACIAD2374	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACIAD2375	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACIAD2376	COG0802	atpase or kinase
ACIAD2377	COG0564	pseudouridine synthase activity
ACIAD2380	COG1187	pseudouridine synthase activity
ACIAD2383	COG2707	UPF0756 membrane protein
ACIAD2384	COG0583	DNA-binding transcription factor activity
ACIAD2385	COG2814	Major facilitator Superfamily
ACIAD2386	COG1957	nucleoside hydrolase
ACIAD2389	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACIAD2390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIAD2392	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIAD2398	COG1937	Protein conserved in bacteria
ACIAD2401	COG2217	Heavy metal translocating P-type atpase
ACIAD2403	COG0729	surface antigen
ACIAD2404	COG0477	Major facilitator Superfamily
ACIAD2405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ACIAD2408	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACIAD2411	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACIAD2413	COG0443	Heat shock 70 kDa protein
ACIAD2415	COG0392	lysyltransferase activity
ACIAD2417	COG2890	protein-(glutamine-N5) methyltransferase activity
ACIAD2418	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACIAD2420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD2421	COG3300	MHYT domain
ACIAD2421	COG5001	Diguanylate cyclase
ACIAD2422	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACIAD2425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIAD2426	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIAD2427	COG1845	cytochrome c oxidase, subunit III
ACIAD2428	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACIAD2429	COG0109	protoheme IX farnesyltransferase activity
ACIAD2430	COG0360	Binds together with S18 to 16S ribosomal RNA
ACIAD2431	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACIAD2432	COG0359	binds to the 23S rRNA
ACIAD2433	COG0305	Participates in initiation and elongation during chromosome replication
ACIAD2434	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACIAD2436	COG1305	Transglutaminase-like
ACIAD2438	COG2308	Evidence 4 Homologs of previously reported genes of
ACIAD2440	COG0445	tRNA wobble uridine modification
ACIAD2443	COG2264	protein methyltransferase activity
ACIAD2446	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ACIAD2447	COG0138	bifunctional purine biosynthesis protein purh
ACIAD2448	COG0151	Belongs to the GarS family
ACIAD2450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACIAD2451	COG2011	ABC-type metal ion transport system permease component
ACIAD2455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIAD2456	COG3161	chorismate lyase activity
ACIAD2461	COG0512	Glutamine amidotransferase of anthranilate synthase
ACIAD2462	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIAD2463	COG0134	indole-3-glycerol-phosphate synthase activity
ACIAD2466	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACIAD2466	COG3608	succinylglutamate desuccinylase aspartoacylase
ACIAD2467	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACIAD2471	COG0586	Pfam SNARE associated Golgi protein
ACIAD2473	COG3739	integral membrane protein
ACIAD2474	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACIAD2476	COG1741	Belongs to the pirin family
ACIAD2504	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACIAD2505	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACIAD2507	COG0535	radical SAM domain protein
ACIAD2509	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD2510	COG2610	gluconate transmembrane transporter activity
ACIAD2511	COG0583	DNA-binding transcription factor activity
ACIAD2515	COG2031	fatty acid transporter
ACIAD2516	COG0183	Belongs to the thiolase family
ACIAD2517	COG4770	biotin carboxylase activity
ACIAD2519	COG4336	lyase activity
ACIAD2520	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACIAD2521	COG1914	H( )-stimulated, divalent metal cation uptake system
ACIAD2522	COG0583	DNA-binding transcription factor activity
ACIAD2525	COG0069	glutamate synthase activity
ACIAD2526	COG2218	PFAM glutamate synthase alpha subunit domain protein
ACIAD2527	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACIAD2533	COG0583	DNA-binding transcription factor activity
ACIAD2534	COG0004	ammonium transporteR
ACIAD2535	COG0477	Major facilitator Superfamily
ACIAD2538	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACIAD2539	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD2541	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ACIAD2542	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD2543	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD2544	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD2545	COG2267	carboxylic ester hydrolase activity
ACIAD2547	COG1802	Transcriptional regulator
ACIAD2550	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD2550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACIAD2553	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIAD2560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACIAD2561	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACIAD2566	COG2962	Rard protein
ACIAD2569	COG0556	nucleotide-excision repair
ACIAD2577	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACIAD2578	COG1381	Involved in DNA repair and RecF pathway recombination
ACIAD2580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIAD2581	COG0571	ribonuclease III activity
ACIAD2584	COG0481	GTPase activity
ACIAD2586	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIAD2588	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIAD2589	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACIAD2590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACIAD2591	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACIAD2595	COG4208	sulfate ABC transporter
ACIAD2596	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACIAD2597	COG0583	DNA-binding transcription factor activity
ACIAD2598	COG4625	pathogenesis
ACIAD2599	COG2171	N-acyltransferase activity
ACIAD2600	COG0602	queuosine metabolic process
ACIAD2601	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACIAD2603	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIAD2604	COG2353	YceI-like domain
ACIAD2606	COG1051	belongs to the nudix hydrolase family
ACIAD2606	COG1056	cytidyltransferase-related domain
ACIAD2607	COG1024	Enoyl-CoA hydratase
ACIAD2608	COG0778	Nitroreductase
ACIAD2609	COG3323	Protein of unknown function (DUF1653)
ACIAD2609	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACIAD2612	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIAD2612	COG0047	phosphoribosylformylglycinamidine synthase activity
ACIAD2614	COG0632	four-way junction helicase activity
ACIAD2615	COG2255	four-way junction helicase activity
ACIAD2618	COG0824	Thioesterase
ACIAD2622	COG0823	Involved in the tonB-independent uptake of proteins
ACIAD2625	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACIAD2626	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIAD2633	COG0628	permease
ACIAD2634	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACIAD2635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACIAD2636	COG0596	Alpha beta hydrolase
ACIAD2639	COG0658	competence protein
ACIAD2639	COG2333	competence protein COMEC
ACIAD2640	COG1136	(ABC) transporter
ACIAD2641	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACIAD2644	COG1671	Belongs to the UPF0178 family
ACIAD2647	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACIAD2649	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD2657	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACIAD2659	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACIAD2662	COG1113	amino acid transport
ACIAD2666	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ACIAD2667	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACIAD2669	COG4638	Rieske (2fe-2S)
ACIAD2670	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACIAD2671	COG0543	2 iron, 2 sulfur cluster binding
ACIAD2671	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD2674	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD2676	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD2680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACIAD2700	COG2828	Protein conserved in bacteria
ACIAD2721	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD2723	COG1335	isochorismatase
ACIAD2725	COG1902	pentaerythritol trinitrate reductase activity
ACIAD2727	COG0583	DNA-binding transcription factor activity
ACIAD2735	COG3008	intermembrane lipid transfer
ACIAD2735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACIAD2736	COG2995	paraquat-inducible protein a
ACIAD2740	COG1309	transcriptional regulator
ACIAD2743	COG1280	lysine exporter protein (LysE YggA)
ACIAD2748	COG2267	carboxylic ester hydrolase activity
ACIAD2759	COG1802	Transcriptional regulator
ACIAD2761	COG0534	Mate efflux family protein
ACIAD2764	COG4774	siderophore transport
ACIAD2765	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ACIAD2768	COG0019	diaminopimelate decarboxylase activity
ACIAD2769	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ACIAD2770	COG1021	2,3-dihydroxybenzoate-AMP ligase
ACIAD2771	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD2773	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD2774	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD2775	COG3433	isochorismatase activity
ACIAD2775	COG1535	isochorismatase
ACIAD2776	COG1169	isochorismate synthase
ACIAD2784	COG3210	domain, Protein
ACIAD2785	COG2831	hemolysin activation secretion protein
ACIAD2790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIAD2794	COG2072	flavoprotein involved in K transport
ACIAD2809	COG3152	Membrane
ACIAD2814	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACIAD2817	COG1414	Transcriptional regulator
ACIAD2818	COG2851	Citrate transporter
ACIAD2820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIAD2821	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACIAD2827	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACIAD2829	COG0037	tRNA processing
ACIAD2832	COG0739	heme binding
ACIAD2832	COG0741	lytic transglycosylase activity
ACIAD2832	COG1196	nuclear chromosome segregation
ACIAD2833	COG0501	Belongs to the peptidase M48B family
ACIAD2835	COG2239	Acts as a magnesium transporter
ACIAD2838	COG0459	protein refolding
ACIAD2839	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACIAD2841	COG1803	Methylglyoxal synthase
ACIAD2841	COG1597	lipid kinase activity
ACIAD2842	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACIAD2846	COG2264	protein methyltransferase activity
ACIAD2847	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIAD2850	COG1929	Belongs to the glycerate kinase type-1 family
ACIAD2852	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACIAD2853	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIAD2854	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACIAD2860	COG0505	Belongs to the CarA family
ACIAD2861	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACIAD2863	COG0589	response to stress
ACIAD2865	COG0589	response to stress
ACIAD2869	COG2321	neutral zinc metallopeptidase
ACIAD2870	COG2354	Protein conserved in bacteria
ACIAD2873	COG0045	succinate-CoA ligase (ADP-forming) activity
ACIAD2874	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD2879	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACIAD2880	COG1053	succinate dehydrogenase
ACIAD2881	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ACIAD2882	COG2009	succinate dehydrogenase
ACIAD2888	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIAD2888	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACIAD2892	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIAD2893	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACIAD2894	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACIAD2897	COG0564	pseudouridine synthase activity
ACIAD2899	COG0358	DNA primase activity
ACIAD2900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACIAD2902	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACIAD2903	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACIAD2907	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIAD2908	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACIAD2909	COG0193	aminoacyl-tRNA hydrolase activity
ACIAD2911	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACIAD2913	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIAD2919	COG0586	Pfam SNARE associated Golgi protein
ACIAD2922	COG0500	methyltransferase
ACIAD2927	COG0321	lipoyl(octanoyl) transferase activity
ACIAD2930	COG0531	amino acid
ACIAD2932	COG1733	regulation of RNA biosynthetic process
ACIAD2933	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACIAD2934	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIAD2934	COG1648	precorrin-2 dehydrogenase activity
ACIAD2935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACIAD2937	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACIAD2938	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACIAD2939	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACIAD2942	COG0671	phosphoesterase, PA-phosphatase related
ACIAD2943	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD2945	COG1538	Outer membrane efflux protein
ACIAD2946	COG0393	Putative heavy-metal-binding
ACIAD2947	COG0393	Putative heavy-metal-binding
ACIAD2948	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD2950	COG0525	valine-tRNA ligase activity
ACIAD2958	COG0004	ammonium transporteR
ACIAD2960	COG0642	Histidine kinase
ACIAD2961	COG0745	RESPONSE REGULATOR receiver
ACIAD2963	COG2814	Major facilitator Superfamily
ACIAD2965	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIAD2968	COG0142	geranyltranstransferase activity
ACIAD2969	COG1113	amino acid transport
ACIAD2973	COG0745	RESPONSE REGULATOR receiver
ACIAD2975	COG2205	protein histidine kinase activity
ACIAD2977	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACIAD2978	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACIAD2982	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD2986	COG2207	Transcriptional regulator
ACIAD2988	COG0183	Belongs to the thiolase family
ACIAD2991	COG4667	esterase of the alpha-beta hydrolase superfamily
ACIAD2996	COG1272	protein, Hemolysin III
ACIAD2997	COG0477	Major facilitator Superfamily
ACIAD3000	COG1408	metallophosphoesterase
ACIAD3001	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIAD3005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACIAD3008	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACIAD3009	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIAD3012	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACIAD3013	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACIAD3014	COG0625	glutathione transferase activity
ACIAD3015	COG2969	positive regulation of protein catabolic process
ACIAD3021	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIAD3022	COG1846	Transcriptional regulator
ACIAD3023	COG1764	response to oxidative stress
ACIAD3034	COG0037	tRNA processing
ACIAD3040	COG0776	regulation of translation
ACIAD3041	COG0072	phenylalanine-tRNA ligase activity
ACIAD3042	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACIAD3046	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACIAD3047	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACIAD3050	COG1238	metal cluster binding
ACIAD3051	COG0625	glutathione transferase activity
ACIAD3054	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACIAD3055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACIAD3056	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD3058	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACIAD3059	COG1660	Displays ATPase and GTPase activities
ACIAD3060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACIAD3061	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACIAD3062	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACIAD3063	COG0617	tRNA 3'-terminal CCA addition
ACIAD3064	COG1555	photosystem II stabilization
ACIAD3064	COG1596	polysaccharide export
ACIAD3065	COG3956	TIGRFAM MazG family protein
ACIAD3068	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIAD3069	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIAD3072	COG0784	Response regulator, receiver
ACIAD3072	COG2205	protein histidine kinase activity
ACIAD3072	COG5002	protein histidine kinase activity
ACIAD3073	COG1024	Enoyl-CoA hydratase
ACIAD3074	COG2084	Dehydrogenase
ACIAD3075	COG3622	Belongs to the hyi family
ACIAD3078	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACIAD3079	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACIAD3080	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACIAD3081	COG0697	spore germination
ACIAD3082	COG0789	Transcriptional regulator
ACIAD3084	COG2814	Major facilitator Superfamily
ACIAD3085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIAD3088	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACIAD3091	COG0084	hydrolase, TatD family'
ACIAD3095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACIAD3102	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACIAD3103	COG0440	acetolactate synthase activity
ACIAD3104	COG0028	Belongs to the TPP enzyme family
ACIAD3106	COG0495	leucyl-tRNA aminoacylation
ACIAD3109	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD3110	COG1136	(ABC) transporter
ACIAD3110	COG0577	efflux transmembrane transporter activity
ACIAD3111	COG1538	Outer membrane efflux protein
ACIAD3112	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIAD3113	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIAD3115	COG3501	Rhs element vgr protein
ACIAD3118	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACIAD3119	COG1162	GTPase activity
ACIAD3121	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACIAD3122	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACIAD3123	COG3783	Cytochrome b(562)
ACIAD3125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIAD3126	COG2003	Belongs to the UPF0758 family
ACIAD3127	COG3781	membrane
ACIAD3128	COG0667	Aldo Keto reductase
ACIAD3129	COG0583	DNA-binding transcription factor activity
ACIAD3133	COG2350	Protein conserved in bacteria
ACIAD3135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACIAD3135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIAD3137	COG1666	GTP binding
ACIAD3139	COG1607	acyl-coa hydrolase
ACIAD3142	COG3453	Protein conserved in bacteria
ACIAD3142	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIAD3145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD3149	COG1183	phosphatidylcholine synthase activity
ACIAD3150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACIAD3155	COG0039	L-malate dehydrogenase activity
ACIAD3158	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIAD3159	COG1702	phosphate starvation-inducible protein PhoH
ACIAD3160	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACIAD3161	COG4773	Receptor
ACIAD3164	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACIAD3168	COG1295	ribonuclease BN
ACIAD3169	COG0583	DNA-binding transcription factor activity
ACIAD3170	COG2814	Major facilitator Superfamily
ACIAD3172	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACIAD3176	COG2205	protein histidine kinase activity
ACIAD3179	COG0557	exoribonuclease II activity
ACIAD3182	COG0339	signal peptide processing
ACIAD3183	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ACIAD3189	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ACIAD3191	COG1960	acyl-CoA dehydrogenase activity
ACIAD3192	COG2072	flavoprotein involved in K transport
ACIAD3193	COG0203	ribosomal protein L17
ACIAD3194	COG0202	RNA polymerase activity
ACIAD3195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACIAD3196	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACIAD3197	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACIAD3198	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACIAD3200	COG0200	Binds to the 23S rRNA
ACIAD3201	COG1841	ribosomal large subunit assembly
ACIAD3202	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACIAD3203	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACIAD3204	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACIAD3205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACIAD3206	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACIAD3207	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACIAD3208	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACIAD3209	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACIAD3210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACIAD3211	COG0255	Belongs to the universal ribosomal protein uL29 family
ACIAD3212	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACIAD3213	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACIAD3214	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACIAD3215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACIAD3216	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACIAD3217	COG0089	rRNA binding
ACIAD3218	COG0088	Forms part of the polypeptide exit tunnel
ACIAD3219	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACIAD3220	COG0051	transcription antitermination factor activity, RNA binding
ACIAD3222	COG0626	cystathionine gamma-synthase activity
ACIAD3223	COG0433	COG0433 Predicted ATPase
ACIAD3226	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD3226	COG1017	nitric oxide dioxygenase activity
ACIAD3227	COG1959	2 iron, 2 sulfur cluster binding
ACIAD3228	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACIAD3230	COG1301	dicarboxylic acid transport
ACIAD3231	COG1946	Acyl-CoA thioesterase
ACIAD3232	COG2937	Belongs to the GPAT DAPAT family
ACIAD3235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACIAD3236	COG1040	competence protein
ACIAD3237	COG0494	nUDIX hydrolase
ACIAD3239	COG0598	Magnesium transport protein CorA
ACIAD3243	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIAD3244	COG1127	ABC transporter
ACIAD3245	COG0513	Belongs to the DEAD box helicase family
ACIAD3247	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACIAD3249	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIAD3250	COG0408	coproporphyrinogen oxidase activity
ACIAD3254	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIAD3255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACIAD3257	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACIAD3259	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACIAD3259	COG0644	oxidoreductase
ACIAD3262	COG1960	acyl-CoA dehydrogenase activity
ACIAD3264	COG1983	PspC domain protein
ACIAD3268	COG0752	glycyl-tRNA synthetase alpha subunit
ACIAD3269	COG0751	glycine-tRNA ligase activity
ACIAD3274	COG0583	DNA-binding transcription factor activity
ACIAD3278	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIAD3288	COG1192	Involved in chromosome partitioning
ACIAD3289	COG0628	permease
ACIAD3291	COG1289	transmembrane transporter activity
ACIAD3295	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACIAD3296	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ACIAD3297	COG2131	deaminase
ACIAD3298	COG4221	oxidoreductase activity
ACIAD3300	COG0277	FAD linked oxidase domain protein
ACIAD3302	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACIAD3307	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACIAD3308	COG5380	lipid catabolic process
ACIAD3309	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ACIAD3310	COG0335	large ribosomal subunit rRNA binding
ACIAD3311	COG0336	Belongs to the RNA methyltransferase TrmD family
ACIAD3312	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACIAD3313	COG0228	four-way junction DNA binding
ACIAD3322	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACIAD3324	COG0194	GDP metabolic process
ACIAD3325	COG1758	RNA polymerase activity
ACIAD3326	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIAD3328	COG2906	2 iron, 2 sulfur cluster binding
ACIAD3337	COG3307	-O-antigen
ACIAD3338	COG4969	Belongs to the N-Me-Phe pilin family
ACIAD3340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIAD3341	COG1982	Orn Lys Arg decarboxylase major
ACIAD3342	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIAD3345	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACIAD3347	COG1704	LemA family
ACIAD3349	COG0493	'glutamate synthase
ACIAD3350	COG0069	glutamate synthase activity
ACIAD3350	COG0067	glutamate synthase
ACIAD3350	COG0070	glutamate synthase
ACIAD3353	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIAD3354	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACIAD3362	COG2226	methyltransferase
ACIAD3363	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIAD3364	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACIAD3365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIAD3368	COG0275	rRNA processing
ACIAD3371	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIAD3380	COG0488	(ABC) transporter
ACIAD3381	COG0028	Belongs to the TPP enzyme family
ACIAD3383	COG4221	oxidoreductase activity
ACIAD3388	COG0745	RESPONSE REGULATOR receiver
ACIAD3389	COG2205	protein histidine kinase activity
ACIAD3390	COG0427	acetyl-CoA hydrolase
ACIAD3395	COG0131	Imidazoleglycerol-phosphate dehydratase
ACIAD3396	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACIAD3397	COG3152	Membrane
ACIAD3398	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACIAD3399	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD3400	COG1132	(ABC) transporter
ACIAD3403	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACIAD3404	COG0107	imidazoleglycerol-phosphate synthase activity
ACIAD3412	COG3158	transport of potassium into the cell
ACIAD3418	COG3177	Filamentation induced by cAMP protein fic
ACIAD3424	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD3441	COG0475	glutathione-regulated potassium exporter activity
ACIAD3441	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIAD3443	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACIAD3445	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD3446	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACIAD3449	COG0629	single-stranded DNA binding
ACIAD3450	COG2814	Major facilitator Superfamily
ACIAD3452	COG0352	thiamine-phosphate diphosphorylase activity
ACIAD3452	COG0351	phosphomethylpyrimidine kinase
ACIAD3452	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACIAD3453	COG3136	membrane protein required for alginate biosynthesis
ACIAD3457	COG3706	GGDEF domain
ACIAD3460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACIAD3463	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIAD3464	COG3162	membrane
ACIAD3470	COG0431	NADPH-dependent FMN reductase
ACIAD3471	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD3473	COG1335	isochorismatase
ACIAD3475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIAD3476	COG3152	Membrane
ACIAD3477	COG0668	transmembrane transport
ACIAD3479	COG1519	Transferase
ACIAD3481	COG2072	flavoprotein involved in K transport
ACIAD3484	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACIAD3488	COG1126	abc transporter atp-binding protein
ACIAD3496	COG1902	pentaerythritol trinitrate reductase activity
ACIAD3500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIAD3501	COG0259	pyridoxamine-phosphate oxidase activity
ACIAD3502	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIAD3505	COG2119	membrane
ACIAD3506	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIAD3508	COG4942	peptidase
ACIAD3510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACIAD3511	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACIAD3514	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACIAD3515	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIAD3516	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIAD3517	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACIAD3518	COG0189	ligase activity
ACIAD3522	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD3523	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACIAD3525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACIAD3526	COG0708	Exodeoxyribonuclease III
ACIAD3528	COG1393	Belongs to the ArsC family
ACIAD3531	COG3706	GGDEF domain
ACIAD3540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD3541	COG4266	Belongs to the allantoicase family
ACIAD3545	COG3150	esterase
ACIAD3548	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACIAD3549	COG2918	glutathione biosynthetic process
ACIAD3552	COG2733	membrane
ACIAD3553	COG0436	Aminotransferase
ACIAD3554	COG0534	Mate efflux family protein
ACIAD3560	COG0688	phosphatidylethanolamine metabolic process
ACIAD3562	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACIAD3563	COG1490	D-aminoacyl-tRNA deacylase activity
ACIAD3567	COG3830	Belongs to the UPF0237 family
ACIAD3567	COG0560	Phosphoserine phosphatase
ACIAD3571	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACIAD3572	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACIAD3573	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACIAD3574	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACIAD3575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACIAD3576	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIAD3581	COG2388	GCN5-related N-acetyl-transferase
ACIAD3582	COG1683	Conserved Protein
ACIAD3583	COG0385	Bile acid
ACIAD3584	COG1335	isochorismatase
ACIAD3585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIAD3587	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACIAD3589	COG0765	amino acid transport
ACIAD3591	COG0765	amino acid transport
ACIAD3592	COG1126	abc transporter atp-binding protein
ACIAD3593	COG2116	formate transmembrane transporter activity
ACIAD3596	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACIAD3598	COG2133	pyrroloquinoline quinone binding
ACIAD3601	COG2983	Belongs to the UPF0260 family
ACIAD3602	COG5487	UPF0391 membrane protein
ACIAD3603	COG0412	Dienelactone hydrolase
ACIAD3606	COG1194	a g-specific adenine glycosylase
ACIAD3611	COG2818	Glycosylase
ACIAD3612	COG1064	alcohol dehydrogenase
ACIAD3613	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACIAD3615	COG0583	DNA-binding transcription factor activity
ACIAD3616	COG0656	L-ascorbic acid biosynthetic process
ACIAD3617	COG2814	Major facilitator Superfamily
ACIAD3619	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACIAD3621	COG0484	heat shock protein binding
ACIAD3627	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACIAD3628	COG2233	PERMEase
ACIAD3629	COG0583	DNA-binding transcription factor activity
ACIAD3633	COG1252	NADH dehydrogenase
ACIAD3636	COG0129	dihydroxy-acid dehydratase activity
ACIAD3637	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACIAD3638	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACIAD3639	COG0428	transporter
ACIAD3641	COG0733	neurotransmitter:sodium symporter activity
ACIAD3642	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD3646	COG0693	protein deglycase activity
ACIAD3647	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACIAD3651	COG0583	DNA-binding transcription factor activity
ACIAD3652	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACIAD3654	COG0443	Heat shock 70 kDa protein
ACIAD3657	COG2951	lytic endotransglycosylase activity
ACIAD3663	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIAD3665	COG0671	phosphoesterase, PA-phosphatase related
ACIAD3666	COG0861	Integral membrane protein TerC family
ACIAD3668	COG0402	S-adenosylhomocysteine deaminase activity
ACIAD3673	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACIAD3680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACIAD3681	COG0706	membrane insertase activity
ACIAD3682	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACIAD3683	COG0594	ribonuclease P activity
ACIAD3684	COG0230	Belongs to the bacterial ribosomal protein bL34 family