locus-tag	class	description
N5P16_00015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N5P16_00025	COG0534	Mate efflux family protein
N5P16_00040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N5P16_00045	COG0254	rRNA binding
N5P16_00060	COG0493	'glutamate synthase
N5P16_00060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N5P16_00070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N5P16_00075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N5P16_00080	COG0425	Belongs to the sulfur carrier protein TusA family
N5P16_00085	COG4535	Mg2 and Co2 transporter CorC
N5P16_00090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N5P16_00110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N5P16_00120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N5P16_00130	COG0789	Transcriptional regulator
N5P16_00135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N5P16_00140	COG0598	Magnesium transport protein CorA
N5P16_00145	COG1185	polyribonucleotide nucleotidyltransferase activity
N5P16_00150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N5P16_00155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N5P16_00160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N5P16_00165	COG1074	ATP-dependent DNA helicase activity
N5P16_00170	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N5P16_00195	COG3188	usher protein
N5P16_00200	COG3121	Chaperone
N5P16_00215	COG2226	methyltransferase
N5P16_00225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N5P16_00235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N5P16_00245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N5P16_00250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N5P16_00250	COG2111	Na H antiporter
N5P16_00255	COG1006	Multisubunit Na H antiporter MnhC subunit
N5P16_00260	COG0651	ATP synthesis coupled electron transport
N5P16_00265	COG1863	multisubunit Na H antiporter MnhE subunit
N5P16_00270	COG2212	antiporter activity
N5P16_00275	COG1320	monovalent cation:proton antiporter activity
N5P16_00280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N5P16_00285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N5P16_00290	COG0195	Participates in both transcription termination and antitermination
N5P16_00295	COG0779	Required for maturation of 30S ribosomal subunits
N5P16_00320	COG0149	triose-phosphate isomerase activity
N5P16_00340	COG0237	dephospho-CoA kinase activity
N5P16_00350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N5P16_00355	COG3123	guanosine phosphorylase activity
N5P16_00365	COG0497	DNA recombination
N5P16_00370	COG1678	Uncharacterized ACR, COG1678
N5P16_00375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N5P16_00380	COG1566	PFAM secretion protein HlyD family protein
N5P16_00405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N5P16_00405	COG2169	Transcriptional regulator
N5P16_00410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N5P16_00420	COG0322	excinuclease ABC activity
N5P16_00440	COG1024	Enoyl-CoA hydratase
N5P16_00440	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5P16_00445	COG0183	Belongs to the thiolase family
N5P16_00460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N5P16_00480	COG0583	DNA-binding transcription factor activity
N5P16_00490	COG1301	dicarboxylic acid transport
N5P16_00495	COG1794	racemase activity, acting on amino acids and derivatives
N5P16_00505	COG0326	Molecular chaperone. Has ATPase activity
N5P16_00520	COG2056	Na+-H+ antiporter family
N5P16_00540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N5P16_00545	COG0085	RNA polymerase activity
N5P16_00550	COG0222	ribosome binding
N5P16_00555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N5P16_00560	COG0081	regulation of translation
N5P16_00565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N5P16_00585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N5P16_00650	COG0824	Thioesterase
N5P16_00670	COG0181	hydroxymethylbilane synthase activity
N5P16_00680	COG3275	phosphorelay sensor kinase activity
N5P16_00685	COG0165	Argininosuccinate lyase
N5P16_00690	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N5P16_00700	COG1538	Outer membrane efflux protein
N5P16_00705	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N5P16_00710	COG0494	nUDIX hydrolase
N5P16_00720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N5P16_00725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5P16_00730	COG0772	Belongs to the SEDS family
N5P16_00735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N5P16_00755	COG4974	Belongs to the 'phage' integrase family
N5P16_00770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N5P16_00780	COG2197	response regulator
N5P16_00795	COG0793	Belongs to the peptidase S41A family
N5P16_00800	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N5P16_00805	COG0795	lipopolysaccharide-transporting ATPase activity
N5P16_00815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N5P16_00845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5P16_00845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N5P16_00850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N5P16_00855	COG0004	ammonium transporteR
N5P16_00860	COG0347	Belongs to the P(II) protein family
N5P16_00870	COG0606	chelatase, subunit chli
N5P16_00885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N5P16_00900	COG0318	PFAM AMP-dependent synthetase and ligase
N5P16_00910	COG0477	Major facilitator Superfamily
N5P16_00915	COG2860	membrane
N5P16_00925	COG1253	flavin adenine dinucleotide binding
N5P16_00940	COG3757	hydrolase, family 25
N5P16_00945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N5P16_00950	COG0477	Major facilitator Superfamily
N5P16_01000	COG1309	transcriptional regulator
N5P16_01030	COG1652	LysM domain
N5P16_01035	COG0758	DNA mediated transformation
N5P16_01040	COG0009	L-threonylcarbamoyladenylate synthase
N5P16_01045	COG1079	Belongs to the binding-protein-dependent transport system permease family
N5P16_01050	COG4603	Belongs to the binding-protein-dependent transport system permease family
N5P16_01055	COG3845	ABC transporter
N5P16_01095	COG0697	spore germination
N5P16_01100	COG1309	transcriptional regulator
N5P16_01115	COG0386	Belongs to the glutathione peroxidase family
N5P16_01140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N5P16_01145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N5P16_01150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N5P16_01155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N5P16_01160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N5P16_01165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N5P16_01175	COG0356	it plays a direct role in the translocation of protons across the membrane
N5P16_01195	COG1121	(ABC) transporter
N5P16_01200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N5P16_01205	COG1280	lysine exporter protein (LysE YggA)
N5P16_01210	COG2837	iron assimilation
N5P16_01220	COG3409	Peptidoglycan-binding domain 1 protein
N5P16_01220	COG5632	N-Acetylmuramoyl-L-alanine amidase
N5P16_01220	COG1388	LysM domain
N5P16_01230	COG0281	malic enzyme
N5P16_01240	COG0018	arginyl-trna synthetase
N5P16_01300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N5P16_01300	COG0519	Catalyzes the synthesis of GMP from XMP
N5P16_01305	COG3111	PFAM Bacterial OB fold (BOF) protein
N5P16_01310	COG2259	Doxx family
N5P16_01315	COG0586	Pfam SNARE associated Golgi protein
N5P16_01330	COG1192	Involved in chromosome partitioning
N5P16_01340	COG0271	Belongs to the BolA IbaG family
N5P16_01365	COG0402	S-adenosylhomocysteine deaminase activity
N5P16_01370	COG2233	PERMEase
N5P16_01375	COG1609	Transcriptional regulator
N5P16_01380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5P16_01385	COG2186	Transcriptional regulator
N5P16_01390	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_01395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N5P16_01400	COG4948	Mandelate Racemase Muconate Lactonizing
N5P16_01405	COG2271	Major facilitator Superfamily
N5P16_01410	COG2721	sulfolactate sulfo-lyase activity
N5P16_01425	COG3121	Chaperone
N5P16_01435	COG3188	usher protein
N5P16_01440	COG3121	Chaperone
N5P16_01450	COG1113	amino acid transport
N5P16_01455	COG0251	oxidation-reduction process
N5P16_01465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5P16_01480	COG1448	Aminotransferase
N5P16_01495	COG0277	FAD linked oxidase domain protein
N5P16_01500	COG1304	FMN binding
N5P16_01505	COG2186	Transcriptional regulator
N5P16_01510	COG1620	l-lactate permease
N5P16_01515	COG0583	DNA-binding transcription factor activity
N5P16_01520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N5P16_01525	COG3307	-O-antigen
N5P16_01530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N5P16_01535	COG0166	Belongs to the GPI family
N5P16_01545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N5P16_01560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N5P16_01570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N5P16_01575	COG0438	transferase activity, transferring glycosyl groups
N5P16_01580	COG0438	transferase activity, transferring glycosyl groups
N5P16_01595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N5P16_01600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N5P16_01630	COG0438	transferase activity, transferring glycosyl groups
N5P16_01645	COG1091	dTDP-4-dehydrorhamnose reductase activity
N5P16_01650	COG1088	dTDP-glucose 4,6-dehydratase activity
N5P16_01670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N5P16_01705	COG3023	N-Acetylmuramoyl-L-alanine amidase
N5P16_01745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N5P16_01755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N5P16_01755	COG1017	nitric oxide dioxygenase activity
N5P16_01775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N5P16_01780	COG0546	phosphoglycolate phosphatase activity
N5P16_01785	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_01800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N5P16_01800	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N5P16_01805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5P16_01810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5P16_01815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_01820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5P16_01825	COG1116	anion transmembrane transporter activity
N5P16_01835	COG2233	PERMEase
N5P16_01840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5P16_01845	COG0251	oxidation-reduction process
N5P16_01850	COG1335	isochorismatase
N5P16_01855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_01860	COG1309	transcriptional regulator
N5P16_01865	COG0596	Alpha beta hydrolase
N5P16_01875	COG0196	riboflavin kinase activity
N5P16_01880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N5P16_01885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N5P16_01890	COG1047	Peptidyl-prolyl cis-trans
N5P16_01935	COG0737	Belongs to the 5'-nucleotidase family
N5P16_01945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N5P16_01950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N5P16_01955	COG0316	Belongs to the HesB IscA family
N5P16_01970	COG0488	(ABC) transporter
N5P16_01980	COG0187	DNA topoisomerase II activity
N5P16_01985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N5P16_01990	COG0592	DNA-directed DNA polymerase activity
N5P16_01995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N5P16_02005	COG0594	ribonuclease P activity
N5P16_02010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N5P16_02015	COG0706	membrane insertase activity
N5P16_02020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N5P16_02070	COG0402	S-adenosylhomocysteine deaminase activity
N5P16_02080	COG0861	Integral membrane protein TerC family
N5P16_02085	COG0671	phosphoesterase, PA-phosphatase related
N5P16_02090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N5P16_02110	COG2951	lytic endotransglycosylase activity
N5P16_02125	COG0443	Heat shock 70 kDa protein
N5P16_02130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N5P16_02135	COG0583	DNA-binding transcription factor activity
N5P16_02150	COG0657	acetylesterase activity
N5P16_02155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N5P16_02185	COG0693	protein deglycase activity
N5P16_02200	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_02205	COG0733	neurotransmitter:sodium symporter activity
N5P16_02215	COG0428	transporter
N5P16_02220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N5P16_02225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N5P16_02230	COG0129	dihydroxy-acid dehydratase activity
N5P16_02240	COG1252	NADH dehydrogenase
N5P16_02250	COG0583	DNA-binding transcription factor activity
N5P16_02255	COG2233	PERMEase
N5P16_02260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N5P16_02285	COG0484	heat shock protein binding
N5P16_02290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N5P16_02300	COG2814	Major facilitator Superfamily
N5P16_02305	COG0656	L-ascorbic acid biosynthetic process
N5P16_02310	COG0583	DNA-binding transcription factor activity
N5P16_02320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N5P16_02325	COG1064	alcohol dehydrogenase
N5P16_02330	COG2818	Glycosylase
N5P16_02350	COG1194	a g-specific adenine glycosylase
N5P16_02360	COG0412	Dienelactone hydrolase
N5P16_02365	COG5487	UPF0391 membrane protein
N5P16_02370	COG2983	Belongs to the UPF0260 family
N5P16_02385	COG2133	pyrroloquinoline quinone binding
N5P16_02395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N5P16_02405	COG2116	formate transmembrane transporter activity
N5P16_02410	COG1126	abc transporter atp-binding protein
N5P16_02415	COG0765	amino acid transport
N5P16_02420	COG0765	amino acid transport
N5P16_02430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N5P16_02440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N5P16_02445	COG1335	isochorismatase
N5P16_02450	COG0385	Bile acid
N5P16_02455	COG1683	Conserved Protein
N5P16_02460	COG2388	GCN5-related N-acetyl-transferase
N5P16_02475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N5P16_02480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N5P16_02485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N5P16_02490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N5P16_02495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N5P16_02500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N5P16_02515	COG3830	Belongs to the UPF0237 family
N5P16_02515	COG0560	Phosphoserine phosphatase
N5P16_02530	COG1490	D-aminoacyl-tRNA deacylase activity
N5P16_02535	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
N5P16_02545	COG0688	phosphatidylethanolamine metabolic process
N5P16_02575	COG0534	Mate efflux family protein
N5P16_02580	COG0436	Aminotransferase
N5P16_02585	COG2733	membrane
N5P16_02600	COG2918	glutathione biosynthetic process
N5P16_02605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N5P16_02615	COG3150	esterase
N5P16_02635	COG4266	Belongs to the allantoicase family
N5P16_02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_02685	COG3706	GGDEF domain
N5P16_02700	COG1393	Belongs to the ArsC family
N5P16_02705	COG0708	Exodeoxyribonuclease III
N5P16_02710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N5P16_02725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5P16_02740	COG0189	ligase activity
N5P16_02745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N5P16_02750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N5P16_02755	COG1181	Belongs to the D-alanine--D-alanine ligase family
N5P16_02760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N5P16_02770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N5P16_02775	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N5P16_02785	COG4942	peptidase
N5P16_02795	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5P16_02800	COG2119	membrane
N5P16_02815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N5P16_02820	COG0259	pyridoxamine-phosphate oxidase activity
N5P16_02825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N5P16_02845	COG1902	pentaerythritol trinitrate reductase activity
N5P16_02875	COG1126	abc transporter atp-binding protein
N5P16_02895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N5P16_02910	COG2072	flavoprotein involved in K transport
N5P16_02915	COG1519	Transferase
N5P16_02925	COG0668	transmembrane transport
N5P16_02930	COG3152	Membrane
N5P16_02935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N5P16_02945	COG1335	isochorismatase
N5P16_02955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_02960	COG0431	NADPH-dependent FMN reductase
N5P16_02980	COG3162	membrane
N5P16_02985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N5P16_03000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N5P16_03030	COG3136	membrane protein required for alginate biosynthesis
N5P16_03035	COG0351	phosphomethylpyrimidine kinase
N5P16_03035	COG0352	thiamine-phosphate diphosphorylase activity
N5P16_03035	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N5P16_03045	COG2814	Major facilitator Superfamily
N5P16_03050	COG0629	single-stranded DNA binding
N5P16_03065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N5P16_03070	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_03080	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
N5P16_03095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N5P16_03095	COG0475	glutathione-regulated potassium exporter activity
N5P16_03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5P16_03205	COG3158	transport of potassium into the cell
N5P16_03235	COG0107	imidazoleglycerol-phosphate synthase activity
N5P16_03240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N5P16_03255	COG1132	(ABC) transporter
N5P16_03260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5P16_03265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N5P16_03270	COG3152	Membrane
N5P16_03275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N5P16_03280	COG0131	Imidazoleglycerol-phosphate dehydratase
N5P16_03315	COG0427	acetyl-CoA hydrolase
N5P16_03340	COG4221	oxidoreductase activity
N5P16_03345	COG2873	o-acetylhomoserine
N5P16_03350	COG0028	Belongs to the TPP enzyme family
N5P16_03355	COG0488	(ABC) transporter
N5P16_03400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5P16_03415	COG0275	rRNA processing
N5P16_03430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N5P16_03435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N5P16_03440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N5P16_03445	COG2226	methyltransferase
N5P16_03480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N5P16_03485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N5P16_03495	COG0069	glutamate synthase activity
N5P16_03495	COG0067	glutamate synthase
N5P16_03495	COG0070	glutamate synthase
N5P16_03500	COG0493	'glutamate synthase
N5P16_03510	COG1704	LemA family
N5P16_03515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
N5P16_03530	COG1181	Belongs to the D-alanine--D-alanine ligase family
N5P16_03540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5P16_03550	COG4969	Belongs to the N-Me-Phe pilin family
N5P16_03555	COG3307	-O-antigen
N5P16_03600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N5P16_03605	COG1758	RNA polymerase activity
N5P16_03610	COG0194	GDP metabolic process
N5P16_03615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N5P16_03655	COG0228	four-way junction DNA binding
N5P16_03660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N5P16_03665	COG0336	Belongs to the RNA methyltransferase TrmD family
N5P16_03670	COG0335	large ribosomal subunit rRNA binding
N5P16_03675	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N5P16_03680	COG5380	lipid catabolic process
N5P16_03685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N5P16_03710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N5P16_03715	COG0277	FAD linked oxidase domain protein
N5P16_03725	COG4221	oxidoreductase activity
N5P16_03730	COG2131	deaminase
N5P16_03735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N5P16_03740	COG2249	NAD(P)H dehydrogenase (quinone) activity
N5P16_03750	COG1289	transmembrane transporter activity
N5P16_03760	COG0628	permease
N5P16_03765	COG1192	Involved in chromosome partitioning
N5P16_03805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5P16_03820	COG0583	DNA-binding transcription factor activity
N5P16_03840	COG0751	glycine-tRNA ligase activity
N5P16_03845	COG0752	glycyl-tRNA synthetase alpha subunit
N5P16_03855	COG0517	IMP dehydrogenase activity
N5P16_03855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
N5P16_03855	COG0617	tRNA 3'-terminal CCA addition
N5P16_03860	COG1983	PspC domain protein
N5P16_03870	COG1960	acyl-CoA dehydrogenase activity
N5P16_03880	COG0644	oxidoreductase
N5P16_03880	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
N5P16_03890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N5P16_03900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N5P16_03905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N5P16_03915	COG0408	coproporphyrinogen oxidase activity
N5P16_03920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5P16_03925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N5P16_03935	COG0513	Belongs to the DEAD box helicase family
N5P16_03940	COG1127	ABC transporter
N5P16_03945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N5P16_03965	COG0598	Magnesium transport protein CorA
N5P16_03975	COG0494	nUDIX hydrolase
N5P16_03980	COG1040	competence protein
N5P16_03985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N5P16_04000	COG2937	Belongs to the GPAT DAPAT family
N5P16_04005	COG1946	Acyl-CoA thioesterase
N5P16_04010	COG1301	dicarboxylic acid transport
N5P16_04020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N5P16_04025	COG1959	2 iron, 2 sulfur cluster binding
N5P16_04030	COG1017	nitric oxide dioxygenase activity
N5P16_04030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N5P16_04045	COG0433	COG0433 Predicted ATPase
N5P16_04050	COG0626	cystathionine gamma-synthase activity
N5P16_04060	COG0051	transcription antitermination factor activity, RNA binding
N5P16_04065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N5P16_04070	COG0088	Forms part of the polypeptide exit tunnel
N5P16_04075	COG0089	rRNA binding
N5P16_04080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N5P16_04085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N5P16_04090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N5P16_04100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N5P16_04105	COG0255	Belongs to the universal ribosomal protein uL29 family
N5P16_04110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N5P16_04115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N5P16_04120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N5P16_04125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N5P16_04130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N5P16_04135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N5P16_04140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N5P16_04145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N5P16_04150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N5P16_04155	COG1841	ribosomal large subunit assembly
N5P16_04160	COG0200	Binds to the 23S rRNA
N5P16_04175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N5P16_04185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N5P16_04190	COG0202	RNA polymerase activity
N5P16_04195	COG0203	ribosomal protein L17
N5P16_04200	COG2072	flavoprotein involved in K transport
N5P16_04205	COG1960	acyl-CoA dehydrogenase activity
N5P16_04210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N5P16_04235	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
N5P16_04240	COG0339	signal peptide processing
N5P16_04245	COG0557	exoribonuclease II activity
N5P16_04270	COG2205	protein histidine kinase activity
N5P16_04295	COG0179	Fumarylacetoacetate (FAA) hydrolase
N5P16_04305	COG2814	Major facilitator Superfamily
N5P16_04310	COG0583	DNA-binding transcription factor activity
N5P16_04315	COG1295	ribonuclease BN
N5P16_04335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N5P16_04350	COG4773	Receptor
N5P16_04355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N5P16_04360	COG1702	phosphate starvation-inducible protein PhoH
N5P16_04365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5P16_04380	COG0039	L-malate dehydrogenase activity
N5P16_04400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N5P16_04405	COG1183	phosphatidylcholine synthase activity
N5P16_04450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5P16_04480	COG1607	acyl-coa hydrolase
N5P16_04490	COG1666	GTP binding
N5P16_04500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N5P16_04500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5P16_04510	COG2350	Protein conserved in bacteria
N5P16_04530	COG0583	DNA-binding transcription factor activity
N5P16_04535	COG0667	Aldo Keto reductase
N5P16_04540	COG3781	membrane
N5P16_04545	COG2003	Belongs to the UPF0758 family
N5P16_04550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N5P16_04555	COG3783	Cytochrome b(562)
N5P16_04560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N5P16_04565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N5P16_04575	COG1162	GTPase activity
N5P16_04580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N5P16_04605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N5P16_04610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N5P16_04615	COG1538	Outer membrane efflux protein
N5P16_04620	COG0577	efflux transmembrane transporter activity
N5P16_04620	COG1136	(ABC) transporter
N5P16_04625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5P16_04640	COG0495	leucyl-tRNA aminoacylation
N5P16_04650	COG0028	Belongs to the TPP enzyme family
N5P16_04660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N5P16_04670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N5P16_04685	COG0084	hydrolase, TatD family'
N5P16_04700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N5P16_04710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N5P16_04715	COG2814	Major facilitator Superfamily
N5P16_04725	COG0789	Transcriptional regulator
N5P16_04730	COG0697	spore germination
N5P16_04760	COG3622	Belongs to the hyi family
N5P16_04765	COG2084	Dehydrogenase
N5P16_04770	COG1024	Enoyl-CoA hydratase
N5P16_04775	COG5002	protein histidine kinase activity
N5P16_04775	COG0784	Response regulator, receiver
N5P16_04775	COG2205	protein histidine kinase activity
N5P16_04790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N5P16_04795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N5P16_04805	COG3956	TIGRFAM MazG family protein
N5P16_04810	COG1596	polysaccharide export
N5P16_04810	COG1555	photosystem II stabilization
N5P16_04815	COG0617	tRNA 3'-terminal CCA addition
N5P16_04820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N5P16_04825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N5P16_04830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N5P16_04835	COG1660	Displays ATPase and GTPase activities
N5P16_04840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N5P16_04845	COG3028	Belongs to the UPF0307 family
N5P16_04850	COG0318	PFAM AMP-dependent synthetase and ligase
N5P16_04855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N5P16_04860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N5P16_04870	COG0625	glutathione transferase activity
N5P16_04875	COG1238	metal cluster binding
N5P16_04890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N5P16_04915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N5P16_04920	COG0072	phenylalanine-tRNA ligase activity
N5P16_04925	COG0776	regulation of translation
N5P16_04945	COG0248	Ppx GppA phosphatase
N5P16_04955	COG0037	tRNA processing
N5P16_04995	COG1764	response to oxidative stress
N5P16_05000	COG1846	Transcriptional regulator
N5P16_05005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5P16_05055	COG2969	positive regulation of protein catabolic process
N5P16_05060	COG0625	glutathione transferase activity
N5P16_05065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N5P16_05070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N5P16_05075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N5P16_05080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N5P16_05085	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N5P16_05100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N5P16_05115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5P16_05120	COG1408	metallophosphoesterase
N5P16_05130	COG0477	Major facilitator Superfamily
N5P16_05135	COG1272	protein, Hemolysin III
N5P16_05160	COG4667	esterase of the alpha-beta hydrolase superfamily
N5P16_05175	COG0183	Belongs to the thiolase family
N5P16_05185	COG2207	Transcriptional regulator
N5P16_05190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N5P16_05205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5P16_05225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N5P16_05230	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N5P16_05240	COG2205	protein histidine kinase activity
N5P16_05245	COG0745	RESPONSE REGULATOR receiver
N5P16_05265	COG1113	amino acid transport
N5P16_05270	COG0142	geranyltranstransferase activity
N5P16_05285	COG1752	Esterase of the alpha-beta hydrolase superfamily
N5P16_05295	COG2814	Major facilitator Superfamily
N5P16_05300	COG0745	RESPONSE REGULATOR receiver
N5P16_05305	COG0642	Histidine kinase
N5P16_05315	COG0004	ammonium transporteR
N5P16_05350	COG0525	valine-tRNA ligase activity
N5P16_05360	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_05365	COG0393	Putative heavy-metal-binding
N5P16_05370	COG0393	Putative heavy-metal-binding
N5P16_05375	COG1538	Outer membrane efflux protein
N5P16_05385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5P16_05390	COG0671	phosphoesterase, PA-phosphatase related
N5P16_05405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N5P16_05410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N5P16_05415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N5P16_05425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N5P16_05430	COG1648	precorrin-2 dehydrogenase activity
N5P16_05430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N5P16_05435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N5P16_05440	COG1733	regulation of RNA biosynthetic process
N5P16_05450	COG0531	amino acid
N5P16_05465	COG0321	lipoyl(octanoyl) transferase activity
N5P16_05490	COG0500	methyltransferase
N5P16_05505	COG0586	Pfam SNARE associated Golgi protein
N5P16_05515	COG1054	Belongs to the UPF0176 family
N5P16_05530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N5P16_05535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N5P16_05540	COG0193	aminoacyl-tRNA hydrolase activity
N5P16_05545	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N5P16_05550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N5P16_05575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N5P16_05580	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N5P16_05590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N5P16_05595	COG0358	DNA primase activity
N5P16_05605	COG0564	pseudouridine synthase activity
N5P16_05620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N5P16_05625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N5P16_05630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N5P16_05660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N5P16_05660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N5P16_05675	COG2009	succinate dehydrogenase
N5P16_05680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N5P16_05685	COG1053	succinate dehydrogenase
N5P16_05690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N5P16_05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5P16_05710	COG0045	succinate-CoA ligase (ADP-forming) activity
N5P16_05725	COG2354	Protein conserved in bacteria
N5P16_05730	COG2321	neutral zinc metallopeptidase
N5P16_05750	COG0589	response to stress
N5P16_05760	COG0589	response to stress
N5P16_05770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N5P16_05775	COG0505	Belongs to the CarA family
N5P16_05795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N5P16_05800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N5P16_05805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N5P16_05820	COG1929	Belongs to the glycerate kinase type-1 family
N5P16_05835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N5P16_05840	COG2264	protein methyltransferase activity
N5P16_05860	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N5P16_05865	COG1597	lipid kinase activity
N5P16_05875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N5P16_05880	COG0459	protein refolding
N5P16_05895	COG2239	Acts as a magnesium transporter
N5P16_05905	COG0501	Belongs to the peptidase M48B family
N5P16_05910	COG1196	nuclear chromosome segregation
N5P16_05910	COG0739	heme binding
N5P16_05910	COG0741	lytic transglycosylase activity
N5P16_05915	COG0037	tRNA processing
N5P16_05925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N5P16_05945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N5P16_05950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N5P16_05960	COG2851	Citrate transporter
N5P16_05965	COG1414	Transcriptional regulator
N5P16_05975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N5P16_05995	COG3152	Membrane
N5P16_06050	COG2072	flavoprotein involved in K transport
N5P16_06060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N5P16_06080	COG2831	hemolysin activation secretion protein
N5P16_06085	COG3210	domain, Protein
N5P16_06105	COG1169	isochorismate synthase
N5P16_06115	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_06120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5P16_06135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5P16_06140	COG1021	2,3-dihydroxybenzoate-AMP ligase
N5P16_06145	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N5P16_06150	COG0019	diaminopimelate decarboxylase activity
N5P16_06165	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
N5P16_06170	COG4774	siderophore transport
N5P16_06185	COG0534	Mate efflux family protein
N5P16_06190	COG1802	Transcriptional regulator
N5P16_06240	COG2267	carboxylic ester hydrolase activity
N5P16_06255	COG1280	lysine exporter protein (LysE YggA)
N5P16_06270	COG1309	transcriptional regulator
N5P16_06295	COG2995	paraquat-inducible protein a
N5P16_06300	COG3008	intermembrane lipid transfer
N5P16_06300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N5P16_06330	COG0583	DNA-binding transcription factor activity
N5P16_06340	COG1902	pentaerythritol trinitrate reductase activity
N5P16_06350	COG1335	isochorismatase
N5P16_06355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_06415	COG2828	Protein conserved in bacteria
N5P16_06510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N5P16_06525	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_06535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5P16_06550	COG0543	2 iron, 2 sulfur cluster binding
N5P16_06550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N5P16_06555	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N5P16_06560	COG4638	Rieske (2fe-2S)
N5P16_06570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N5P16_06575	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N5P16_06590	COG1113	amino acid transport
N5P16_06605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N5P16_06615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N5P16_06650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N5P16_06660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N5P16_06675	COG1671	Belongs to the UPF0178 family
N5P16_06685	COG4591	ABC-type transport system involved in lipoprotein release permease component
N5P16_06690	COG1136	(ABC) transporter
N5P16_06695	COG0658	competence protein
N5P16_06695	COG2333	competence protein COMEC
N5P16_06710	COG0596	Alpha beta hydrolase
N5P16_06715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N5P16_06720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N5P16_06725	COG0628	permease
N5P16_06760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N5P16_06765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N5P16_06780	COG0823	Involved in the tonB-independent uptake of proteins
N5P16_06800	COG0824	Thioesterase
N5P16_06810	COG2255	four-way junction helicase activity
N5P16_06815	COG0632	four-way junction helicase activity
N5P16_06825	COG0047	phosphoribosylformylglycinamidine synthase activity
N5P16_06825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N5P16_06840	COG3323	Protein of unknown function (DUF1653)
N5P16_06840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N5P16_06845	COG0778	Nitroreductase
N5P16_06850	COG1024	Enoyl-CoA hydratase
N5P16_06855	COG1051	belongs to the nudix hydrolase family
N5P16_06855	COG1056	cytidyltransferase-related domain
N5P16_06860	COG2353	YceI-like domain
N5P16_06865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N5P16_06875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N5P16_06880	COG0602	queuosine metabolic process
N5P16_06885	COG2171	N-acyltransferase activity
N5P16_06890	COG4625	pathogenesis
N5P16_06895	COG0583	DNA-binding transcription factor activity
N5P16_06900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
N5P16_06905	COG4208	sulfate ABC transporter
N5P16_06920	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N5P16_06925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N5P16_06930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N5P16_06935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N5P16_06945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5P16_06955	COG0481	GTPase activity
N5P16_06970	COG0571	ribonuclease III activity
N5P16_06975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N5P16_06985	COG1381	Involved in DNA repair and RecF pathway recombination
N5P16_06990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N5P16_07010	COG0436	Aminotransferase
N5P16_07020	COG2199	diguanylate cyclase activity
N5P16_07035	COG0556	nucleotide-excision repair
N5P16_07045	COG2962	Rard protein
N5P16_07065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N5P16_07070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N5P16_07105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N5P16_07120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N5P16_07120	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5P16_07135	COG1802	Transcriptional regulator
N5P16_07145	COG2267	carboxylic ester hydrolase activity
N5P16_07150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5P16_07155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_07160	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_07165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N5P16_07175	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_07180	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N5P16_07195	COG0477	Major facilitator Superfamily
N5P16_07200	COG0004	ammonium transporteR
N5P16_07205	COG0583	DNA-binding transcription factor activity
N5P16_07225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N5P16_07230	COG2218	PFAM glutamate synthase alpha subunit domain protein
N5P16_07235	COG0069	glutamate synthase activity
N5P16_07250	COG0583	DNA-binding transcription factor activity
N5P16_07255	COG1914	H( )-stimulated, divalent metal cation uptake system
N5P16_07260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N5P16_07265	COG4336	lyase activity
N5P16_07275	COG4770	biotin carboxylase activity
N5P16_07280	COG0183	Belongs to the thiolase family
N5P16_07285	COG2031	fatty acid transporter
N5P16_07300	COG0583	DNA-binding transcription factor activity
N5P16_07305	COG2610	gluconate transmembrane transporter activity
N5P16_07310	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_07320	COG0535	radical SAM domain protein
N5P16_07330	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
N5P16_07335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N5P16_07390	COG1741	Belongs to the pirin family
N5P16_07400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N5P16_07405	COG3739	integral membrane protein
N5P16_07415	COG0586	Pfam SNARE associated Golgi protein
N5P16_07420	COG0302	gtp cyclohydrolase
N5P16_07430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N5P16_07435	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N5P16_07435	COG3608	succinylglutamate desuccinylase aspartoacylase
N5P16_07450	COG0134	indole-3-glycerol-phosphate synthase activity
N5P16_07455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N5P16_07460	COG0512	Glutamine amidotransferase of anthranilate synthase
N5P16_07470	COG0174	glutamine synthetase
N5P16_07480	COG3161	chorismate lyase activity
N5P16_07485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N5P16_07500	COG2011	ABC-type metal ion transport system permease component
N5P16_07505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N5P16_07515	COG0151	Belongs to the GarS family
N5P16_07520	COG0138	bifunctional purine biosynthesis protein purh
N5P16_07525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N5P16_07535	COG2264	protein methyltransferase activity
N5P16_07545	COG0445	tRNA wobble uridine modification
N5P16_07555	COG2308	Evidence 4 Homologs of previously reported genes of
N5P16_07565	COG1305	Transglutaminase-like
N5P16_07575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N5P16_07580	COG0305	Participates in initiation and elongation during chromosome replication
N5P16_07585	COG0359	binds to the 23S rRNA
N5P16_07590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N5P16_07595	COG0360	Binds together with S18 to 16S ribosomal RNA
N5P16_07600	COG0109	protoheme IX farnesyltransferase activity
N5P16_07605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N5P16_07610	COG1845	cytochrome c oxidase, subunit III
N5P16_07615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N5P16_07620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N5P16_07635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
N5P16_07640	COG3300	MHYT domain
N5P16_07640	COG5001	Diguanylate cyclase
N5P16_07645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_07655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N5P16_07660	COG2890	protein-(glutamine-N5) methyltransferase activity
N5P16_07670	COG0392	lysyltransferase activity
N5P16_07675	COG0443	Heat shock 70 kDa protein
N5P16_07685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N5P16_07695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N5P16_07710	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
N5P16_07715	COG0477	Major facilitator Superfamily
N5P16_07720	COG0729	surface antigen
N5P16_07730	COG2217	Heavy metal translocating P-type atpase
N5P16_07740	COG1937	Protein conserved in bacteria
N5P16_07770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5P16_07780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N5P16_07785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N5P16_07795	COG1957	nucleoside hydrolase
N5P16_07800	COG2814	Major facilitator Superfamily
N5P16_07805	COG0583	DNA-binding transcription factor activity
N5P16_07810	COG2707	UPF0756 membrane protein
N5P16_07815	COG1187	pseudouridine synthase activity
N5P16_07830	COG0564	pseudouridine synthase activity
N5P16_07835	COG0802	atpase or kinase
N5P16_07840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N5P16_07845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N5P16_07850	COG1923	regulation of RNA biosynthetic process
N5P16_07855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5P16_07860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N5P16_07870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N5P16_07875	COG0357	Ribosomal RNA small subunit methyltransferase G
N5P16_07880	COG1192	Involved in chromosome partitioning
N5P16_07885	COG1475	DNA binding
N5P16_07890	COG1132	(ABC) transporter
N5P16_07895	COG1663	tetraacyldisaccharide 4'-kinase activity
N5P16_07900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N5P16_07915	COG0084	hydrolase, TatD family'
N5P16_07925	COG2165	general secretion pathway protein
N5P16_07940	COG3156	type II secretion system protein K
N5P16_07950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N5P16_07970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N5P16_07980	COG0776	regulation of translation
N5P16_07995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N5P16_08005	COG0284	orotidine-5'-phosphate decarboxylase activity
N5P16_08025	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N5P16_08045	COG1253	flavin adenine dinucleotide binding
N5P16_08050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N5P16_08055	COG0730	response to heat
N5P16_08075	COG4773	Receptor
N5P16_08080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5P16_08135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N5P16_08145	COG3100	YcgL domain-containing protein
N5P16_08155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N5P16_08165	COG4109	DRTGG domain
N5P16_08195	COG0612	Peptidase, M16
N5P16_08200	COG0552	protein localization to endoplasmic reticulum
N5P16_08225	COG4890	Cyd operon protein YbgT
N5P16_08230	COG1294	oxidase, subunit
N5P16_08245	COG0617	tRNA 3'-terminal CCA addition
N5P16_08255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N5P16_08265	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N5P16_08275	COG0477	Major facilitator Superfamily
N5P16_08280	COG3706	GGDEF domain
N5P16_08290	COG1960	acyl-CoA dehydrogenase activity
N5P16_08295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N5P16_08300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5P16_08310	COG0024	Methionine aminopeptidase
N5P16_08315	COG0052	Belongs to the universal ribosomal protein uS2 family
N5P16_08320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N5P16_08340	COG2951	lytic endotransglycosylase activity
N5P16_08345	COG0772	Belongs to the SEDS family
N5P16_08355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N5P16_08355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N5P16_08360	COG0842	Transport permease protein
N5P16_08365	COG1131	(ABC) transporter
N5P16_08385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N5P16_08405	COG3634	alkyl hydroperoxide reductase activity
N5P16_08410	COG3384	dioxygenase
N5P16_08420	COG1953	Uracil, thiamine, allantoin
N5P16_08440	COG1720	tRNA m6t6A37 methyltransferase activity
N5P16_08445	COG2199	diguanylate cyclase activity
N5P16_08445	COG2203	Gaf domain
N5P16_08465	COG0642	Histidine kinase
N5P16_08485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N5P16_08490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N5P16_08495	COG3139	Protein of unknown function (DUF1315)
N5P16_08500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N5P16_08505	COG1301	dicarboxylic acid transport
N5P16_08510	COG1960	acyl-CoA dehydrogenase activity
N5P16_08515	COG0693	protein deglycase activity
N5P16_08530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N5P16_08540	COG2195	Cleaves the N-terminal amino acid of tripeptides
N5P16_08550	COG3022	response to hydroperoxide
N5P16_08560	COG1067	ATP-dependent peptidase activity
N5P16_08580	COG0254	rRNA binding
N5P16_08595	COG1509	lysine 2,3-aminomutase activity
N5P16_08600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N5P16_08605	COG1966	Carbon starvation protein
N5P16_08610	COG2879	small protein
N5P16_08615	COG0714	Associated with various cellular activities
N5P16_08725	COG3093	addiction module antidote protein HigA
N5P16_08750	COG5410	chromosome segregation
N5P16_08755	COG3567	Phage-associated protein, HI1409 family
N5P16_08775	COG3561	AntA/AntB antirepressor
N5P16_08995	COG4264	IucA IucC family
N5P16_09075	COG0450	alkyl hydroperoxide reductase
N5P16_09080	COG1643	Atp-dependent helicase
N5P16_09090	COG2223	nitrite transmembrane transporter activity
N5P16_09095	COG0596	Alpha beta hydrolase
N5P16_09100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N5P16_09110	COG3706	GGDEF domain
N5P16_09130	COG1045	serine acetyltransferase
N5P16_09150	COG0436	Aminotransferase
N5P16_09155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N5P16_09160	COG0386	Belongs to the glutathione peroxidase family
N5P16_09190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N5P16_09195	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N5P16_09220	COG0012	GTP binding
N5P16_09225	COG2011	ABC-type metal ion transport system permease component
N5P16_09230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N5P16_09235	COG1464	Belongs to the NlpA lipoprotein family
N5P16_09270	COG0765	amino acid transport
N5P16_09275	COG1126	abc transporter atp-binding protein
N5P16_09290	COG0217	transcriptional regulatory protein
N5P16_09305	COG2193	ferroxidase activity
N5P16_09320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N5P16_09330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N5P16_09330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N5P16_09335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N5P16_09355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N5P16_09360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N5P16_09365	COG2353	YceI-like domain
N5P16_09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N5P16_09390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N5P16_09430	COG0505	Belongs to the CarA family
N5P16_09450	COG1454	alcohol dehydrogenase
N5P16_09455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N5P16_09465	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
N5P16_09470	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
N5P16_09485	COG0308	aminopeptidase N
N5P16_09500	COG0589	response to stress
N5P16_09510	COG0504	CTP synthase activity
N5P16_09515	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N5P16_09520	COG0148	phosphopyruvate hydratase activity
N5P16_09530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N5P16_09545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N5P16_09555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N5P16_09555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N5P16_09555	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N5P16_09560	COG1105	Belongs to the carbohydrate kinase PfkB family
N5P16_09565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N5P16_09565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N5P16_09580	COG0024	Methionine aminopeptidase
N5P16_09585	COG1714	RDD family
N5P16_09595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N5P16_09605	COG3135	benzoate transporter
N5P16_09615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N5P16_09620	COG0583	DNA-binding transcription factor activity
N5P16_09645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N5P16_09650	COG1309	transcriptional regulator
N5P16_09665	COG4245	von Willebrand factor, type A
N5P16_09710	COG1358	cellular component organization or biogenesis
N5P16_09755	COG0824	Thioesterase
N5P16_09760	COG1454	alcohol dehydrogenase
N5P16_09765	COG1278	Cold shock
N5P16_09770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N5P16_09775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N5P16_09825	COG3829	transcription factor binding
N5P16_09830	COG0069	glutamate synthase activity
N5P16_09835	COG2850	peptidyl-arginine hydroxylation
N5P16_09840	COG2851	Citrate transporter
N5P16_09845	COG0424	maF-like protein
N5P16_09855	COG0126	phosphoglycerate kinase activity
N5P16_09865	COG0191	fructose-bisphosphate aldolase activity
N5P16_09870	COG0697	spore germination
N5P16_09875	COG0778	Nitroreductase
N5P16_09890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N5P16_09905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N5P16_09910	COG0243	molybdopterin cofactor binding
N5P16_09915	COG1116	anion transmembrane transporter activity
N5P16_09915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5P16_09925	COG2223	nitrite transmembrane transporter activity
N5P16_09930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5P16_09935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5P16_09940	COG0243	molybdopterin cofactor binding
N5P16_09965	COG0315	cyclic pyranopterin monophosphate synthase activity
N5P16_09965	COG0521	Mo-molybdopterin cofactor biosynthetic process
N5P16_09970	COG0303	'Molybdopterin
N5P16_09975	COG0725	ABC transporter, periplasmic molybdate-binding protein
N5P16_09980	COG4149	molybdate abc transporter
N5P16_09985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N5P16_09995	COG0436	Aminotransferase
N5P16_10000	COG0697	spore germination
N5P16_10025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N5P16_10050	COG1960	acyl-CoA dehydrogenase activity
N5P16_10075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N5P16_10085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N5P16_10090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N5P16_10095	COG0509	glycine decarboxylation via glycine cleavage system
N5P16_10110	COG1132	(ABC) transporter
N5P16_10120	COG0668	transmembrane transport
N5P16_10125	COG3122	Protein conserved in bacteria
N5P16_10135	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N5P16_10140	COG0640	Transcriptional regulator
N5P16_10255	COG2207	Transcriptional regulator
N5P16_10260	COG1902	pentaerythritol trinitrate reductase activity
N5P16_10265	COG1073	alpha beta
N5P16_10270	COG2207	Transcriptional regulator
N5P16_10275	COG4628	conserved protein (DUF2132)
N5P16_10285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_10290	COG1024	Enoyl-CoA hydratase
N5P16_10295	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_10300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5P16_10315	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_10325	COG1960	acyl-CoA dehydrogenase activity
N5P16_10330	COG1024	Enoyl-CoA hydratase
N5P16_10350	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N5P16_10355	COG2814	Major facilitator Superfamily
N5P16_10370	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N5P16_10385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_10425	COG2116	formate transmembrane transporter activity
N5P16_10435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N5P16_10435	COG2755	lipolytic protein G-D-S-L family
N5P16_10530	COG1595	DNA-templated transcription, initiation
N5P16_10545	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
N5P16_10550	COG2223	nitrite transmembrane transporter activity
N5P16_10595	COG4774	siderophore transport
N5P16_10600	COG1045	serine acetyltransferase
N5P16_10640	COG3052	prosthetic group binding
N5P16_10645	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N5P16_10660	COG1271	oxidase subunit
N5P16_10665	COG1294	oxidase, subunit
N5P16_10685	COG0583	DNA-binding transcription factor activity
N5P16_10690	COG1027	Aspartate ammonia-lyase
N5P16_10695	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_10695	COG0604	alcohol dehydrogenase
N5P16_10695	COG3321	synthase
N5P16_10705	COG0523	cobalamin synthesis protein
N5P16_10710	COG1469	GTP cyclohydrolase I activity
N5P16_10715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N5P16_10725	COG0439	Biotin carboxylase
N5P16_10735	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N5P16_10740	COG2072	flavoprotein involved in K transport
N5P16_10755	COG1309	transcriptional regulator
N5P16_10765	COG2814	Major facilitator Superfamily
N5P16_10770	COG1024	Enoyl-CoA hydratase
N5P16_10785	COG1960	acyl-CoA dehydrogenase activity
N5P16_10805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_10810	COG1414	Transcriptional regulator
N5P16_10820	COG4993	Dehydrogenase
N5P16_10825	COG3659	wide pore channel activity
N5P16_10830	COG3420	alginic acid biosynthetic process
N5P16_10835	COG0710	3-dehydroquinate dehydratase activity
N5P16_10840	COG3485	protocatechuate 3,4-dioxygenase
N5P16_10845	COG3485	protocatechuate 3,4-dioxygenase
N5P16_10850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N5P16_10855	COG2271	Major facilitator Superfamily
N5P16_10860	COG0596	Alpha beta hydrolase
N5P16_10865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N5P16_10870	COG0183	Belongs to the thiolase family
N5P16_10875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5P16_10880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N5P16_10885	COG1414	Transcriptional regulator
N5P16_10890	COG1024	Enoyl-CoA hydratase
N5P16_10895	COG1960	acyl-CoA dehydrogenase activity
N5P16_10905	COG2814	Major facilitator Superfamily
N5P16_10915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5P16_10925	COG2814	Major facilitator Superfamily
N5P16_10930	COG1960	acyl-CoA dehydrogenase activity
N5P16_10935	COG1024	Enoyl-CoA hydratase
N5P16_10940	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_10945	COG1250	3-hydroxyacyl-CoA dehydrogenase
N5P16_10950	COG0183	Belongs to the thiolase family
N5P16_10965	COG2814	Major facilitator Superfamily
N5P16_10980	COG2814	Major facilitator Superfamily
N5P16_10985	COG0644	oxidoreductase
N5P16_10985	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
N5P16_11010	COG0583	DNA-binding transcription factor activity
N5P16_11015	COG1380	Effector of murein hydrolase LrgA
N5P16_11025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N5P16_11040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N5P16_11045	COG2267	carboxylic ester hydrolase activity
N5P16_11050	COG0671	phosphoesterase, PA-phosphatase related
N5P16_11050	COG2453	phosphatase
N5P16_11065	COG4589	Belongs to the CDS family
N5P16_11075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N5P16_11110	COG1960	acyl-CoA dehydrogenase activity
N5P16_11115	COG0583	DNA-binding transcription factor activity
N5P16_11125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N5P16_11130	COG0583	DNA-binding transcription factor activity
N5P16_11140	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5P16_11140	COG1902	pentaerythritol trinitrate reductase activity
N5P16_11150	COG0596	Alpha beta hydrolase
N5P16_11155	COG0477	Major facilitator Superfamily
N5P16_11160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N5P16_11165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N5P16_11175	COG0506	proline dehydrogenase activity
N5P16_11175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N5P16_11175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N5P16_11180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N5P16_11195	COG1968	undecaprenyl-diphosphatase activity
N5P16_11215	COG1396	sequence-specific DNA binding
N5P16_11240	COG0642	Histidine kinase
N5P16_11245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N5P16_11255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N5P16_11280	COG0730	response to heat
N5P16_11325	COG1960	acyl-CoA dehydrogenase activity
N5P16_11330	COG0183	Belongs to the thiolase family
N5P16_11335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N5P16_11350	COG1024	Enoyl-CoA hydratase
N5P16_11355	COG1960	acyl-CoA dehydrogenase activity
N5P16_11360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N5P16_11375	COG0583	DNA-binding transcription factor activity
N5P16_11385	COG2175	clavaminate synthase activity
N5P16_11390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N5P16_11405	COG0667	Aldo Keto reductase
N5P16_11410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_11425	COG2175	clavaminate synthase activity
N5P16_11455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5P16_11465	COG1045	serine acetyltransferase
N5P16_11470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N5P16_11475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N5P16_11500	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_11520	COG0318	PFAM AMP-dependent synthetase and ligase
N5P16_11525	COG1024	Enoyl-CoA hydratase
N5P16_11535	COG0183	Belongs to the thiolase family
N5P16_11540	COG1024	Enoyl-CoA hydratase
N5P16_11570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N5P16_11575	COG1960	acyl-CoA dehydrogenase activity
N5P16_11580	COG1846	Transcriptional regulator
N5P16_11655	COG0583	DNA-binding transcription factor activity
N5P16_11660	COG1053	succinate dehydrogenase
N5P16_11670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_11685	COG0747	negative chemotaxis
N5P16_11705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_11710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5P16_11715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5P16_11720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5P16_11735	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N5P16_11750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N5P16_11760	COG4206	TonB-dependent receptor
N5P16_11770	COG1132	(ABC) transporter
N5P16_11775	COG1132	(ABC) transporter
N5P16_11795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N5P16_11800	COG0601	transmembrane transport
N5P16_11830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N5P16_11840	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N5P16_11850	COG4122	O-methyltransferase activity
N5P16_11880	COG2274	protein secretion by the type I secretion system
N5P16_11890	COG1137	ATPase activity
N5P16_11895	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N5P16_11905	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N5P16_11910	COG0517	IMP dehydrogenase activity
N5P16_11910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N5P16_11915	COG0215	cysteine-tRNA ligase activity
N5P16_11965	COG1595	DNA-templated transcription, initiation
N5P16_11975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N5P16_11980	COG1116	anion transmembrane transporter activity
N5P16_11985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N5P16_11990	COG2186	Transcriptional regulator
N5P16_11995	COG3781	membrane
N5P16_12010	COG0531	amino acid
N5P16_12030	COG0604	alcohol dehydrogenase
N5P16_12035	COG1733	regulation of RNA biosynthetic process
N5P16_12040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N5P16_12045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5P16_12050	COG0183	Belongs to the thiolase family
N5P16_12055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N5P16_12060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N5P16_12065	COG4829	muconolactone delta-isomerase
N5P16_12070	COG4948	Mandelate Racemase Muconate Lactonizing
N5P16_12075	COG0583	DNA-binding transcription factor activity
N5P16_12080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
N5P16_12085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N5P16_12090	COG3485	protocatechuate 3,4-dioxygenase
N5P16_12095	COG3135	benzoate transporter
N5P16_12100	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_12105	COG0543	2 iron, 2 sulfur cluster binding
N5P16_12105	COG0633	Ferredoxin
N5P16_12110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N5P16_12115	COG4638	Rieske (2fe-2S)
N5P16_12120	COG0583	DNA-binding transcription factor activity
N5P16_12125	COG2814	Major facilitator Superfamily
N5P16_12135	COG3284	Transcriptional regulator
N5P16_12150	COG0657	acetylesterase activity
N5P16_12175	COG2194	sulfuric ester hydrolase activity
N5P16_12180	COG0745	RESPONSE REGULATOR receiver
N5P16_12185	COG0642	Histidine kinase
N5P16_12195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N5P16_12200	COG2040	homocysteine
N5P16_12205	COG0531	amino acid
N5P16_12230	COG1960	acyl-CoA dehydrogenase activity
N5P16_12235	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N5P16_12240	COG2207	Transcriptional regulator
N5P16_12245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5P16_12250	COG0776	regulation of translation
N5P16_12275	COG0822	iron-sulfur transferase activity
N5P16_12280	COG0316	Belongs to the HesB IscA family
N5P16_12285	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N5P16_12290	COG0443	Heat shock 70 kDa protein
N5P16_12295	COG0633	Ferredoxin
N5P16_12310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N5P16_12330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N5P16_12340	COG0268	Binds directly to 16S ribosomal RNA
N5P16_12360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N5P16_12365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N5P16_12370	COG2137	regulation of response to DNA damage stimulus
N5P16_12385	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5P16_12390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N5P16_12395	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N5P16_12405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5P16_12415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N5P16_12420	COG0575	Belongs to the CDS family
N5P16_12425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N5P16_12430	COG0233	cytoplasmic translational termination
N5P16_12435	COG0528	UMP kinase activity
N5P16_12440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N5P16_12445	COG3852	Histidine kinase
N5P16_12460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N5P16_12465	COG2755	lipolytic protein G-D-S-L family
N5P16_12465	COG0657	acetylesterase activity
N5P16_12470	COG1742	UPF0060 membrane protein
N5P16_12475	COG0542	response to heat
N5P16_12480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N5P16_12490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N5P16_12500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N5P16_12505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N5P16_12510	COG0569	domain protein
N5P16_12515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N5P16_12530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N5P16_12540	COG1585	Membrane protein implicated in regulation of membrane protease activity
N5P16_12545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N5P16_12550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N5P16_12555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N5P16_12575	COG1522	sequence-specific DNA binding
N5P16_12580	COG1113	amino acid transport
N5P16_12600	COG1301	dicarboxylic acid transport
N5P16_12620	COG2815	serine threonine protein kinase
N5P16_12620	COG0515	serine threonine protein kinase
N5P16_12640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N5P16_12660	COG4783	chaperone-mediated protein folding
N5P16_12690	COG0167	dihydroorotate dehydrogenase activity
N5P16_12710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N5P16_12725	COG0513	Belongs to the DEAD box helicase family
N5P16_12745	COG2363	Small membrane protein
N5P16_12755	COG2022	thiamine diphosphate biosynthetic process
N5P16_12775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N5P16_12780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N5P16_12795	COG1126	abc transporter atp-binding protein
N5P16_12800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N5P16_12820	COG0235	Class ii aldolase
N5P16_12835	COG2988	succinylglutamate desuccinylase activity
N5P16_12840	COG3724	N-succinylarginine dihydrolase activity
N5P16_12845	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_12850	COG3138	arginine N-succinyltransferase
N5P16_12855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N5P16_12880	COG0189	ligase activity
N5P16_12880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N5P16_12890	COG0531	amino acid
N5P16_12895	COG4106	trans-aconitate 2-methyltransferase activity
N5P16_12915	COG0540	Belongs to the ATCase OTCase family
N5P16_12920	COG0116	Belongs to the methyltransferase superfamily
N5P16_12920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N5P16_12930	COG0129	dihydroxy-acid dehydratase activity
N5P16_12945	COG1765	OsmC-like protein
N5P16_12955	COG0667	Aldo Keto reductase
N5P16_12970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N5P16_12975	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N5P16_12985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N5P16_12990	COG0527	aspartate kinase activity
N5P16_12995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N5P16_13010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N5P16_13020	COG3038	cytochrome b561
N5P16_13025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N5P16_13030	COG2252	PERMEase
N5P16_13040	COG0659	secondary active sulfate transmembrane transporter activity
N5P16_13055	COG0589	response to stress
N5P16_13075	COG3634	alkyl hydroperoxide reductase activity
N5P16_13090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N5P16_13095	COG0583	DNA-binding transcription factor activity
N5P16_13105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N5P16_13115	COG1686	Belongs to the peptidase S11 family
N5P16_13120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N5P16_13135	COG0482	sulfurtransferase activity
N5P16_13140	COG2915	High frequency lysogenization protein hflD homolog
N5P16_13155	COG0616	signal peptide processing
N5P16_13160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N5P16_13170	COG0573	inorganic phosphate transmembrane transporter activity
N5P16_13175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N5P16_13180	COG0076	glutamate decarboxylase activity
N5P16_13185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N5P16_13200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N5P16_13210	COG0783	Belongs to the Dps family
N5P16_13225	COG3193	protein, possibly involved in utilization of glycolate and propanediol
N5P16_13230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N5P16_13265	COG0612	Peptidase, M16
N5P16_13270	COG0038	chloride channel
N5P16_13280	COG1823	symporter activity
N5P16_13295	COG2351	hydroxyisourate hydrolase activity
N5P16_13310	COG1686	Belongs to the peptidase S11 family
N5P16_13320	COG0415	Belongs to the DNA photolyase family
N5P16_13335	COG1215	transferase activity, transferring glycosyl groups
N5P16_13385	COG1113	amino acid transport
N5P16_13400	COG2771	luxR family
N5P16_13410	COG4774	siderophore transport
N5P16_13420	COG1595	DNA-templated transcription, initiation
N5P16_13425	COG1538	Outer membrane efflux protein
N5P16_13450	COG1902	pentaerythritol trinitrate reductase activity
N5P16_13450	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5P16_13455	COG0697	spore germination
N5P16_13460	COG0583	DNA-binding transcription factor activity
N5P16_13470	COG0418	dihydroorotase activity
N5P16_13475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N5P16_13490	COG0833	amino acid
N5P16_13520	COG4172	Belongs to the ABC transporter superfamily
N5P16_13525	COG4239	(ABC) transporter, permease
N5P16_13530	COG4174	ABC transporter (Permease)
N5P16_13535	COG4166	transmembrane transport
N5P16_13540	COG0741	lytic transglycosylase activity
N5P16_13540	COG0741	lytic transglycosylase activity
N5P16_13540	COG1388	LysM domain
N5P16_13540	COG1388	LysM domain
N5P16_13570	COG0792	nuclease activity
N5P16_13590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_13595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_13600	COG0006	proline dipeptidase activity
N5P16_13640	COG0463	Glycosyl transferase, family 2
N5P16_13655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N5P16_13665	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N5P16_13670	COG3384	dioxygenase
N5P16_13680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N5P16_13685	COG2878	Part of a membrane complex involved in electron transport
N5P16_13690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N5P16_13700	COG0563	adenylate kinase activity
N5P16_13715	COG0768	penicillin binding
N5P16_13720	COG0742	ribosomal rna small subunit methyltransferase
N5P16_13740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N5P16_13745	COG0830	nickel cation binding
N5P16_13750	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
N5P16_13760	COG0804	urea catabolic process
N5P16_13765	COG0832	Belongs to the urease beta subunit family
N5P16_13770	COG0831	urea catabolic process
N5P16_13775	COG0829	nickel cation binding
N5P16_13800	COG1253	flavin adenine dinucleotide binding
N5P16_13830	COG2851	Citrate transporter
N5P16_13840	COG0175	sulfate reduction
N5P16_13845	COG1492	cobalamin metabolic process
N5P16_13850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N5P16_13855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N5P16_13865	COG1773	rubredoxin
N5P16_13870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N5P16_13880	COG0583	DNA-binding transcription factor activity
N5P16_13890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N5P16_13895	COG0705	Rhomboid family
N5P16_13895	COG0457	Tetratricopeptide repeat
N5P16_13900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N5P16_13905	COG4181	ATPase activity
N5P16_13915	COG0288	reversible hydration of carbon dioxide
N5P16_13925	COG4771	TonB-dependent receptor
N5P16_13935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
N5P16_13950	COG3048	D-serine ammonia-lyase activity
N5P16_13955	COG0306	phosphate transporter
N5P16_13970	COG2223	nitrite transmembrane transporter activity
N5P16_13980	COG2066	Belongs to the glutaminase family
N5P16_13985	COG0242	peptide deformylase activity
N5P16_13990	COG0561	phosphatase activity
N5P16_14005	COG0400	carboxylic ester hydrolase activity
N5P16_14030	COG1215	transferase activity, transferring glycosyl groups
N5P16_14035	COG1649	PFAM Uncharacterised BCR, COG1649
N5P16_14035	COG0726	polysaccharide deacetylase
N5P16_14045	COG4681	YaeQ
N5P16_14055	COG0523	cobalamin synthesis protein
N5P16_14065	COG1607	acyl-coa hydrolase
N5P16_14075	COG1063	alcohol dehydrogenase
N5P16_14080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N5P16_14085	COG0508	dehydrogenase complex catalyzes the overall conversion of
N5P16_14090	COG0022	dehydrogenase e1 component
N5P16_14095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N5P16_14100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N5P16_14115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N5P16_14120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N5P16_14125	COG1309	transcriptional regulator
N5P16_14130	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_14135	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
N5P16_14140	COG0579	oxidoreductase
N5P16_14180	COG0028	Belongs to the TPP enzyme family
N5P16_14185	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_14190	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
N5P16_14195	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_14200	COG2267	carboxylic ester hydrolase activity
N5P16_14210	COG2271	Major facilitator Superfamily
N5P16_14215	COG0446	pyridine nucleotide-disulphide oxidoreductase
N5P16_14240	COG2146	nitrite reductase [NAD(P)H] activity
N5P16_14245	COG1414	Transcriptional regulator
N5P16_14250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N5P16_14270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N5P16_14300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N5P16_14305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N5P16_14310	COG1120	ATPase activity
N5P16_14320	COG0583	DNA-binding transcription factor activity
N5P16_14335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N5P16_14355	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_14435	COG3210	domain, Protein
N5P16_14440	COG2831	hemolysin activation secretion protein
N5P16_14455	COG1595	DNA-templated transcription, initiation
N5P16_14465	COG3220	belongs to the UPF0276 family
N5P16_14485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N5P16_14490	COG0405	Gamma-glutamyltransferase
N5P16_14495	COG2814	Major facilitator Superfamily
N5P16_14500	COG1566	PFAM secretion protein HlyD family protein
N5P16_14505	COG2050	protein possibly involved in aromatic compounds catabolism
N5P16_14520	COG1090	epimerase
N5P16_14540	COG0420	3'-5' exonuclease activity
N5P16_14555	COG1968	undecaprenyl-diphosphatase activity
N5P16_14575	COG0735	belongs to the Fur family
N5P16_14580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N5P16_14585	COG2914	Belongs to the UPF0125 (RnfH) family
N5P16_14595	COG0121	glutamine amidotransferase
N5P16_14605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N5P16_14615	COG0756	dUTP diphosphatase activity
N5P16_14620	COG0210	DNA helicase
N5P16_14625	COG2885	chlorophyll binding
N5P16_14630	COG0204	Acyl-transferase
N5P16_14640	COG0850	regulation of cytokinetic process
N5P16_14650	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N5P16_14660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N5P16_14660	COG1674	ftsk spoiiie
N5P16_14665	COG0492	ferredoxin-NADP+ reductase activity
N5P16_14670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N5P16_14675	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N5P16_14690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N5P16_14695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N5P16_14700	COG0049	tRNA binding
N5P16_14705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N5P16_14720	COG1981	membrane
N5P16_14725	COG2755	lipolytic protein G-D-S-L family
N5P16_14725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N5P16_14735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N5P16_14735	COG0352	thiamine-phosphate diphosphorylase activity
N5P16_14735	COG0351	phosphomethylpyrimidine kinase
N5P16_14745	COG1652	LysM domain
N5P16_14750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5P16_14755	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_14765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N5P16_14770	COG1399	metal-binding, possibly nucleic acid-binding protein
N5P16_14775	COG3101	peptidyl-lysine hydroxylation
N5P16_14780	COG0009	L-threonylcarbamoyladenylate synthase
N5P16_14790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N5P16_14795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N5P16_14815	COG4106	trans-aconitate 2-methyltransferase activity
N5P16_14830	COG2226	methyltransferase
N5P16_14830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5P16_14830	COG0596	Alpha beta hydrolase
N5P16_14835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N5P16_14860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N5P16_14870	COG1196	nuclear chromosome segregation
N5P16_14880	COG0730	response to heat
N5P16_14890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N5P16_14895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N5P16_14905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N5P16_14915	COG0560	Phosphoserine phosphatase
N5P16_14925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
N5P16_14935	COG1530	ribonuclease E activity
N5P16_14940	COG0424	maF-like protein
N5P16_14945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N5P16_14950	COG1792	Involved in formation and maintenance of cell shape
N5P16_14955	COG1077	Cell shape determining protein MreB Mrl
N5P16_14960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5P16_14965	COG0154	amidase activity
N5P16_14970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N5P16_15030	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
N5P16_15035	COG0693	protein deglycase activity
N5P16_15045	COG1752	Esterase of the alpha-beta hydrolase superfamily
N5P16_15050	COG1115	amino acid carrier protein
N5P16_15055	COG0786	glutamate:sodium symporter activity
N5P16_15065	COG2814	Major facilitator Superfamily
N5P16_15070	COG1289	transmembrane transporter activity
N5P16_15080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N5P16_15125	COG1376	ErfK ybiS ycfS ynhG family protein
N5P16_15130	COG2832	Protein of unknown function (DUF454)
N5P16_15145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N5P16_15150	COG0643	Histidine kinase
N5P16_15150	COG2198	Histidine kinase
N5P16_15155	COG0840	transmembrane signaling receptor activity
N5P16_15190	COG0442	prolyl-tRNA aminoacylation
N5P16_15220	COG0717	Belongs to the dCTP deaminase family
N5P16_15235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N5P16_15240	COG0489	protein tyrosine kinase activity
N5P16_15255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5P16_15255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N5P16_15280	COG2233	PERMEase
N5P16_15300	COG2226	methyltransferase
N5P16_15325	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N5P16_15330	COG2081	HI0933 family
N5P16_15340	COG0668	transmembrane transport
N5P16_15360	COG0583	DNA-binding transcription factor activity
N5P16_15370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N5P16_15380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5P16_15385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N5P16_15390	COG0713	ATP synthesis coupled electron transport
N5P16_15400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5P16_15405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N5P16_15415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
N5P16_15425	COG0649	NAD binding
N5P16_15425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5P16_15430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5P16_15435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N5P16_15445	COG2205	protein histidine kinase activity
N5P16_15450	COG0745	RESPONSE REGULATOR receiver
N5P16_15465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N5P16_15470	COG3422	double-strand break repair
N5P16_15480	COG2824	Alkylphosphonate utilization operon protein PhnA
N5P16_15500	COG0564	pseudouridine synthase activity
N5P16_15525	COG1902	pentaerythritol trinitrate reductase activity
N5P16_15530	COG4772	TonB-dependent receptor
N5P16_15535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N5P16_15540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N5P16_15550	COG1970	mechanosensitive ion channel activity
N5P16_15555	COG1217	gtp-binding protein TYPA
N5P16_15560	COG2233	PERMEase
N5P16_15565	COG2813	Specifically methylates the guanine in position
N5P16_15570	COG0833	amino acid
N5P16_15590	COG0183	Belongs to the thiolase family
N5P16_15600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N5P16_15620	COG2132	Multicopper oxidase
N5P16_15630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N5P16_15650	COG0742	ribosomal rna small subunit methyltransferase
N5P16_15655	COG1968	undecaprenyl-diphosphatase activity
N5P16_15660	COG1214	PFAM Peptidase M22, glycoprotease
N5P16_15670	COG0494	nUDIX hydrolase
N5P16_15715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N5P16_15720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N5P16_15725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N5P16_15730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N5P16_15780	COG2199	diguanylate cyclase activity
N5P16_15810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N5P16_15815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N5P16_15825	COG0653	protein targeting
N5P16_15830	COG0450	alkyl hydroperoxide reductase
N5P16_15845	COG0285	dihydrofolate synthase activity
N5P16_15850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N5P16_15855	COG0159	tryptophan synthase activity
N5P16_15890	COG4206	TonB-dependent receptor
N5P16_15895	COG2096	Adenosyltransferase
N5P16_15920	COG2315	Protein conserved in bacteria
N5P16_15925	COG0745	RESPONSE REGULATOR receiver
N5P16_15930	COG2205	protein histidine kinase activity
N5P16_15940	COG1960	acyl-CoA dehydrogenase activity
N5P16_15945	COG1960	acyl-CoA dehydrogenase activity
N5P16_16000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N5P16_16035	COG0438	transferase activity, transferring glycosyl groups
N5P16_16040	COG0463	Glycosyl transferase, family 2
N5P16_16045	COG0726	polysaccharide deacetylase
N5P16_16065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N5P16_16070	COG5002	protein histidine kinase activity
N5P16_16085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N5P16_16090	COG0343	queuine tRNA-ribosyltransferase activity
N5P16_16095	COG1862	Preprotein translocase
N5P16_16125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5P16_16130	COG1028	Short-chain dehydrogenase reductase Sdr
N5P16_16140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N5P16_16170	COG2986	histidine ammonia-lyase
N5P16_16185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N5P16_16195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N5P16_16230	COG0124	histidyl-tRNA synthetase
N5P16_16235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N5P16_16240	COG1426	Protein conserved in bacteria
N5P16_16250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N5P16_16255	COG0105	UTP biosynthetic process
N5P16_16275	COG0793	Belongs to the peptidase S41A family
N5P16_16290	COG2267	carboxylic ester hydrolase activity
N5P16_16295	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N5P16_16300	COG1012	belongs to the aldehyde dehydrogenase family
N5P16_16305	COG3265	gluconokinase activity
N5P16_16315	COG0800	Aldolase
N5P16_16325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N5P16_16330	COG0280	phosphate acetyltransferase
N5P16_16330	COG0857	belongs to the CobB CobQ family
N5P16_16340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N5P16_16340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N5P16_16355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N5P16_16360	COG0740	serine-type endopeptidase activity
N5P16_16365	COG0544	peptidyl-prolyl cis-trans isomerase activity
N5P16_16370	COG4774	siderophore transport
N5P16_16375	COG3128	pkhd-type hydroxylase
N5P16_16380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N5P16_16385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5P16_16390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N5P16_16390	COG2813	Specifically methylates the guanine in position
N5P16_16400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N5P16_16415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N5P16_16435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N5P16_16450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N5P16_16490	COG0788	formyltetrahydrofolate deformylase activity
N5P16_16515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N5P16_16515	COG4651	solute:proton antiporter activity
N5P16_16540	COG0210	DNA helicase
N5P16_16565	COG2900	Belongs to the SlyX family
N5P16_16570	COG0488	(ABC) transporter
N5P16_16575	COG1280	lysine exporter protein (LysE YggA)
N5P16_16580	COG0405	Gamma-glutamyltransferase
N5P16_16585	COG1560	Kdo2-lipid A biosynthetic process
N5P16_16595	COG1301	dicarboxylic acid transport
N5P16_16620	COG0101	tRNA pseudouridine synthase activity
N5P16_16630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N5P16_16640	COG0473	3-isopropylmalate dehydrogenase activity
N5P16_16650	COG0066	3-isopropylmalate dehydratase activity
N5P16_16660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N5P16_16670	COG0583	DNA-binding transcription factor activity
N5P16_16695	COG0494	nUDIX hydrolase
N5P16_16705	COG1960	acyl-CoA dehydrogenase activity
N5P16_16710	COG0753	catalase activity
N5P16_16725	COG0583	DNA-binding transcription factor activity
N5P16_16735	COG0625	glutathione transferase activity
N5P16_16745	COG0546	phosphoglycolate phosphatase activity
N5P16_16755	COG1530	ribonuclease E activity
N5P16_16760	COG0318	PFAM AMP-dependent synthetase and ligase
N5P16_16775	COG0450	alkyl hydroperoxide reductase
N5P16_16785	COG4974	Belongs to the 'phage' integrase family