locus-tag	class	description
I9192_00010	COG0592	DNA-directed DNA polymerase activity
I9192_00020	COG0187	DNA topoisomerase II activity
I9192_00030	COG0488	(ABC) transporter
I9192_00040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I9192_00045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I9192_00050	COG0596	Alpha beta hydrolase
I9192_00070	COG0657	acetylesterase activity
I9192_00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I9192_00215	COG1309	transcriptional regulator
I9192_00220	COG1116	anion transmembrane transporter activity
I9192_00225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9192_00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_00235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_00240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_00245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I9192_00245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I9192_00270	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_00275	COG0546	phosphoglycolate phosphatase activity
I9192_00280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I9192_00295	COG1309	transcriptional regulator
I9192_00315	COG2207	Transcriptional regulator
I9192_00325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I9192_00355	COG3023	N-Acetylmuramoyl-L-alanine amidase
I9192_00385	COG1596	polysaccharide export
I9192_00410	COG2244	polysaccharide biosynthetic process
I9192_00440	COG1216	Glycosyl transferase, family 2
I9192_00445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I9192_00450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I9192_00465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9192_00470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9192_00505	COG1454	alcohol dehydrogenase
I9192_00525	COG0235	Class ii aldolase
I9192_00545	COG0271	Belongs to the BolA IbaG family
I9192_00555	COG1192	Involved in chromosome partitioning
I9192_00565	COG0586	Pfam SNARE associated Golgi protein
I9192_00570	COG2259	Doxx family
I9192_00580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9192_00580	COG0519	Catalyzes the synthesis of GMP from XMP
I9192_00610	COG1902	pentaerythritol trinitrate reductase activity
I9192_00615	COG1519	Transferase
I9192_00620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9192_00625	COG0668	transmembrane transport
I9192_00635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9192_00655	COG0431	NADPH-dependent FMN reductase
I9192_00665	COG2814	Major facilitator Superfamily
I9192_00690	COG4452	Inner membrane protein CreD
I9192_00695	COG2205	protein histidine kinase activity
I9192_00700	COG0745	RESPONSE REGULATOR receiver
I9192_00730	COG0281	malic enzyme
I9192_00775	COG2837	iron assimilation
I9192_00790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I9192_00795	COG1121	(ABC) transporter
I9192_00815	COG0356	it plays a direct role in the translocation of protons across the membrane
I9192_00835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I9192_00845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I9192_00880	COG3385	transposase activity
I9192_00895	COG0386	Belongs to the glutathione peroxidase family
I9192_00915	COG1309	transcriptional regulator
I9192_00920	COG0697	spore germination
I9192_00925	COG0009	L-threonylcarbamoyladenylate synthase
I9192_00930	COG0758	DNA mediated transformation
I9192_00935	COG1652	LysM domain
I9192_00950	COG4771	TonB-dependent receptor
I9192_00970	COG1309	transcriptional regulator
I9192_01010	COG2133	pyrroloquinoline quinone binding
I9192_01030	COG0784	Response regulator, receiver
I9192_01030	COG2205	protein histidine kinase activity
I9192_01035	COG3162	membrane
I9192_01040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9192_01050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9192_01095	COG1253	flavin adenine dinucleotide binding
I9192_01105	COG2860	membrane
I9192_01115	COG0477	Major facilitator Superfamily
I9192_01130	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_01145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I9192_01185	COG0673	inositol 2-dehydrogenase activity
I9192_01200	COG1929	Belongs to the glycerate kinase type-1 family
I9192_01205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I9192_01210	COG0738	Major facilitator superfamily
I9192_01230	COG1012	belongs to the aldehyde dehydrogenase family
I9192_01235	COG1024	Enoyl-CoA hydratase
I9192_01260	COG0606	chelatase, subunit chli
I9192_01270	COG0347	Belongs to the P(II) protein family
I9192_01275	COG0004	ammonium transporteR
I9192_01285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9192_01285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9192_01300	COG0586	Pfam SNARE associated Golgi protein
I9192_01310	COG0772	Belongs to the SEDS family
I9192_01315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9192_01320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I9192_01325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9192_01350	COG0704	Plays a role in the regulation of phosphate uptake
I9192_01355	COG2873	o-acetylhomoserine
I9192_01365	COG0488	(ABC) transporter
I9192_01380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I9192_01425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I9192_01470	COG0427	acetyl-CoA hydrolase
I9192_01495	COG0789	Transcriptional regulator
I9192_01500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9192_01500	COG3320	Male sterility
I9192_01510	COG0583	DNA-binding transcription factor activity
I9192_01515	COG4221	oxidoreductase activity
I9192_01595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9192_01635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I9192_01640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I9192_01645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I9192_01650	COG2226	methyltransferase
I9192_01700	COG0070	glutamate synthase
I9192_01700	COG0069	glutamate synthase activity
I9192_01700	COG0067	glutamate synthase
I9192_01705	COG0493	'glutamate synthase
I9192_01715	COG0307	riboflavin synthase, alpha
I9192_01720	COG1320	monovalent cation:proton antiporter activity
I9192_01725	COG2212	antiporter activity
I9192_01730	COG1863	multisubunit Na H antiporter MnhE subunit
I9192_01735	COG0651	ATP synthesis coupled electron transport
I9192_01740	COG1006	Multisubunit Na H antiporter MnhC subunit
I9192_01745	COG2111	Na H antiporter
I9192_01745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9192_01770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I9192_01790	COG2826	transposase and inactivated derivatives, IS30 family
I9192_01830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9192_01840	COG2226	methyltransferase
I9192_01860	COG3385	transposase activity
I9192_01870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I9192_01875	COG1074	ATP-dependent DNA helicase activity
I9192_01880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9192_01885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I9192_01900	COG0598	Magnesium transport protein CorA
I9192_01905	COG2841	Protein conserved in bacteria
I9192_01910	COG0789	Transcriptional regulator
I9192_01925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I9192_01950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I9192_01975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9192_01980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I9192_01985	COG4535	Mg2 and Co2 transporter CorC
I9192_01990	COG0425	Belongs to the sulfur carrier protein TusA family
I9192_02010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I9192_02010	COG0644	oxidoreductase
I9192_02020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I9192_02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9192_02075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I9192_02105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I9192_02110	COG0254	rRNA binding
I9192_02115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9192_02125	COG0534	Mate efflux family protein
I9192_02135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9192_02145	COG1960	acyl-CoA dehydrogenase activity
I9192_02165	COG0408	coproporphyrinogen oxidase activity
I9192_02170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9192_02175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9192_02195	COG0513	Belongs to the DEAD box helicase family
I9192_02200	COG1127	ABC transporter
I9192_02205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I9192_02210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9192_02225	COG0598	Magnesium transport protein CorA
I9192_02235	COG0494	nUDIX hydrolase
I9192_02240	COG1040	competence protein
I9192_02245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I9192_02255	COG2937	Belongs to the GPAT DAPAT family
I9192_02260	COG1946	Acyl-CoA thioesterase
I9192_02265	COG1301	dicarboxylic acid transport
I9192_02280	COG1959	2 iron, 2 sulfur cluster binding
I9192_02290	COG1017	nitric oxide dioxygenase activity
I9192_02290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I9192_02295	COG0433	COG0433 Predicted ATPase
I9192_02300	COG0626	cystathionine gamma-synthase activity
I9192_02310	COG0051	transcription antitermination factor activity, RNA binding
I9192_02315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I9192_02320	COG0088	Forms part of the polypeptide exit tunnel
I9192_02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I9192_02365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I9192_02385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I9192_02400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I9192_02425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I9192_02435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I9192_02440	COG0202	RNA polymerase activity
I9192_02445	COG0203	ribosomal protein L17
I9192_02450	COG2072	flavoprotein involved in K transport
I9192_02455	COG1960	acyl-CoA dehydrogenase activity
I9192_02460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I9192_02500	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I9192_02505	COG0339	signal peptide processing
I9192_02520	COG0557	exoribonuclease II activity
I9192_02550	COG0765	amino acid transport
I9192_02555	COG0765	amino acid transport
I9192_02560	COG1126	abc transporter atp-binding protein
I9192_02565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9192_02570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9192_02580	COG2814	Major facilitator Superfamily
I9192_02605	COG0179	Fumarylacetoacetate (FAA) hydrolase
I9192_02635	COG0697	spore germination
I9192_02640	COG1295	ribonuclease BN
I9192_02655	COG1946	Acyl-CoA thioesterase
I9192_02690	COG3781	membrane
I9192_02695	COG2003	Belongs to the UPF0758 family
I9192_02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I9192_02705	COG3783	Cytochrome b(562)
I9192_02740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I9192_02750	COG1162	GTPase activity
I9192_02755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I9192_02780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_02785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_02790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_02805	COG1538	Outer membrane efflux protein
I9192_02810	COG1136	(ABC) transporter
I9192_02810	COG0577	efflux transmembrane transporter activity
I9192_02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_02845	COG1309	transcriptional regulator
I9192_02850	COG0028	Belongs to the TPP enzyme family
I9192_02855	COG0440	acetolactate synthase activity
I9192_02860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I9192_02900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I9192_02905	COG1426	Protein conserved in bacteria
I9192_02940	COG0004	ammonium transporteR
I9192_02950	COG3622	Belongs to the hyi family
I9192_02955	COG2084	Dehydrogenase
I9192_02960	COG1024	Enoyl-CoA hydratase
I9192_02965	COG0784	Response regulator, receiver
I9192_02965	COG5002	protein histidine kinase activity
I9192_02965	COG2205	protein histidine kinase activity
I9192_02985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9192_02995	COG3956	TIGRFAM MazG family protein
I9192_03000	COG1555	photosystem II stabilization
I9192_03010	COG0617	tRNA 3'-terminal CCA addition
I9192_03015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I9192_03025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I9192_03030	COG1660	Displays ATPase and GTPase activities
I9192_03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I9192_03040	COG3028	Belongs to the UPF0307 family
I9192_03050	COG2205	protein histidine kinase activity
I9192_03055	COG0745	RESPONSE REGULATOR receiver
I9192_03060	COG2315	Protein conserved in bacteria
I9192_03070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I9192_03090	COG2096	Adenosyltransferase
I9192_03095	COG4206	TonB-dependent receptor
I9192_03125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_03135	COG3384	dioxygenase
I9192_03170	COG1764	response to oxidative stress
I9192_03175	COG1846	Transcriptional regulator
I9192_03180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9192_03195	COG2853	Lipoprotein
I9192_03235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9192_03235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9192_03270	COG0489	protein tyrosine kinase activity
I9192_03275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I9192_03335	COG0442	prolyl-tRNA aminoacylation
I9192_03360	COG0840	transmembrane signaling receptor activity
I9192_03365	COG2198	Histidine kinase
I9192_03365	COG0784	Response regulator, receiver
I9192_03365	COG0643	Histidine kinase
I9192_03380	COG3539	Fimbrial protein
I9192_03390	COG3121	Chaperone
I9192_03400	COG3539	Fimbrial protein
I9192_03415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I9192_03430	COG0084	hydrolase, TatD family'
I9192_03440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I9192_03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9192_03470	COG0583	DNA-binding transcription factor activity
I9192_03475	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_03480	COG2271	Major facilitator Superfamily
I9192_03485	COG3959	Transketolase, thiamine diphosphate binding domain
I9192_03490	COG3958	Transketolase
I9192_03500	COG2186	Transcriptional regulator
I9192_03505	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_03515	COG4948	Mandelate Racemase Muconate Lactonizing
I9192_03525	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_03535	COG0738	Major facilitator superfamily
I9192_03545	COG2188	Transcriptional regulator
I9192_03560	COG0523	cobalamin synthesis protein
I9192_03570	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_03575	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_03580	COG2814	Major facilitator Superfamily
I9192_03590	COG0154	amidase activity
I9192_03595	COG1609	Transcriptional regulator
I9192_03600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9192_03610	COG0154	amidase activity
I9192_03635	COG2814	Major facilitator Superfamily
I9192_03690	COG1862	Preprotein translocase
I9192_03720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I9192_03730	COG0582	viral genome integration into host DNA
I9192_03740	COG4115	mRNA cleavage
I9192_03825	COG0583	DNA-binding transcription factor activity
I9192_03840	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_03845	COG0583	DNA-binding transcription factor activity
I9192_03850	COG0247	lactate metabolic process
I9192_03850	COG0277	FAD linked oxidase domain protein
I9192_03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9192_03860	COG1012	belongs to the aldehyde dehydrogenase family
I9192_03865	COG5383	Protein conserved in bacteria
I9192_03875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9192_03880	COG5002	protein histidine kinase activity
I9192_03885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I9192_03910	COG0438	transferase activity, transferring glycosyl groups
I9192_03935	COG3306	glycosyltransferase involved in LPS biosynthesis
I9192_04015	COG1960	acyl-CoA dehydrogenase activity
I9192_04020	COG1960	acyl-CoA dehydrogenase activity
I9192_04030	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_04075	COG0625	glutathione transferase activity
I9192_04090	COG1238	metal cluster binding
I9192_04110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I9192_04155	COG0072	phenylalanine-tRNA ligase activity
I9192_04160	COG0776	regulation of translation
I9192_04180	COG0248	Ppx GppA phosphatase
I9192_04190	COG0037	tRNA processing
I9192_04235	COG5290	Psort location Cytoplasmic, score
I9192_04240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I9192_04255	COG0745	RESPONSE REGULATOR receiver
I9192_04260	COG2205	protein histidine kinase activity
I9192_04270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9192_04290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I9192_04300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I9192_04305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9192_04315	COG0713	ATP synthesis coupled electron transport
I9192_04320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9192_04325	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9192_04335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I9192_04350	COG0583	DNA-binding transcription factor activity
I9192_04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9192_04370	COG2050	protein possibly involved in aromatic compounds catabolism
I9192_04375	COG1566	PFAM secretion protein HlyD family protein
I9192_04380	COG2814	Major facilitator Superfamily
I9192_04385	COG1278	Cold shock
I9192_04395	COG3177	Filamentation induced by cAMP protein fic
I9192_04410	COG0306	phosphate transporter
I9192_04485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9192_04500	COG2851	Citrate transporter
I9192_04505	COG1253	flavin adenine dinucleotide binding
I9192_04525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I9192_04530	COG2894	cell division
I9192_04535	COG0850	regulation of cytokinetic process
I9192_04545	COG0204	Acyl-transferase
I9192_04550	COG2885	chlorophyll binding
I9192_04560	COG0756	dUTP diphosphatase activity
I9192_04565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9192_04580	COG0121	glutamine amidotransferase
I9192_04585	COG2703	oxygen carrier activity
I9192_04595	COG2914	Belongs to the UPF0125 (RnfH) family
I9192_04600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9192_04605	COG0735	belongs to the Fur family
I9192_04625	COG1968	undecaprenyl-diphosphatase activity
I9192_04650	COG0420	3'-5' exonuclease activity
I9192_04680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9192_04690	COG0786	glutamate:sodium symporter activity
I9192_04695	COG2059	Chromate
I9192_04700	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9192_04705	COG1607	acyl-coa hydrolase
I9192_04725	COG0523	cobalamin synthesis protein
I9192_04730	COG4681	YaeQ
I9192_04750	COG0726	polysaccharide deacetylase
I9192_04750	COG1649	PFAM Uncharacterised BCR, COG1649
I9192_04755	COG1215	transferase activity, transferring glycosyl groups
I9192_04790	COG1309	transcriptional regulator
I9192_04800	COG1024	Enoyl-CoA hydratase
I9192_04910	COG0305	Participates in initiation and elongation during chromosome replication
I9192_04945	COG0582	viral genome integration into host DNA
I9192_04955	COG1113	amino acid transport
I9192_04960	COG2828	Protein conserved in bacteria
I9192_04970	COG0142	geranyltranstransferase activity
I9192_04975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9192_04990	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9192_05005	COG2194	sulfuric ester hydrolase activity
I9192_05015	COG0642	Histidine kinase
I9192_05030	COG0004	ammonium transporteR
I9192_05055	COG2852	Protein conserved in bacteria
I9192_05060	COG0525	valine-tRNA ligase activity
I9192_05070	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_05090	COG0393	Putative heavy-metal-binding
I9192_05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_05110	COG0671	phosphoesterase, PA-phosphatase related
I9192_05125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I9192_05135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I9192_05145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I9192_05150	COG1648	precorrin-2 dehydrogenase activity
I9192_05150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I9192_05155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I9192_05185	COG0531	amino acid
I9192_05200	COG0321	lipoyl(octanoyl) transferase activity
I9192_05205	COG2921	Belongs to the UPF0250 family
I9192_05230	COG1280	lysine exporter protein (LysE YggA)
I9192_05235	COG0586	Pfam SNARE associated Golgi protein
I9192_05250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9192_05270	COG0193	aminoacyl-tRNA hydrolase activity
I9192_05275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I9192_05280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9192_05310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I9192_05325	COG0358	DNA primase activity
I9192_05335	COG0564	pseudouridine synthase activity
I9192_05360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I9192_05365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I9192_05370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9192_05430	COG0477	Major facilitator Superfamily
I9192_05455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I9192_05460	COG1597	lipid kinase activity
I9192_05465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9192_05475	COG0459	protein refolding
I9192_05485	COG0584	glycerophosphoryl diester phosphodiesterase
I9192_05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_05495	COG2239	Acts as a magnesium transporter
I9192_05525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9192_05530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9192_05535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9192_05555	COG1113	amino acid transport
I9192_05565	COG0019	diaminopimelate decarboxylase activity
I9192_05570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I9192_05590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I9192_05625	COG3328	transposase activity
I9192_05635	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I9192_05650	COG0596	Alpha beta hydrolase
I9192_05655	COG0833	amino acid
I9192_05665	COG0833	amino acid
I9192_05675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9192_05680	COG0418	dihydroorotase activity
I9192_05700	COG0501	Belongs to the peptidase M48B family
I9192_05705	COG0741	lytic transglycosylase activity
I9192_05710	COG0037	tRNA processing
I9192_05720	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I9192_05725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9192_05760	COG3152	Membrane
I9192_05800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9192_05820	COG0582	viral genome integration into host DNA
I9192_05825	COG0668	transmembrane transport
I9192_05830	COG0625	glutathione transferase activity
I9192_05835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_05845	COG0583	DNA-binding transcription factor activity
I9192_05850	COG2610	gluconate transmembrane transporter activity
I9192_05855	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_05875	COG0583	DNA-binding transcription factor activity
I9192_05890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_05940	COG3328	transposase activity
I9192_05980	COG1414	Transcriptional regulator
I9192_05985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9192_05990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_05995	COG0183	Belongs to the thiolase family
I9192_06000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I9192_06005	COG0596	Alpha beta hydrolase
I9192_06010	COG2271	Major facilitator Superfamily
I9192_06015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9192_06020	COG3485	protocatechuate 3,4-dioxygenase
I9192_06025	COG3485	protocatechuate 3,4-dioxygenase
I9192_06030	COG0710	3-dehydroquinate dehydratase activity
I9192_06035	COG3420	alginic acid biosynthetic process
I9192_06040	COG3659	wide pore channel activity
I9192_06045	COG4993	Dehydrogenase
I9192_06055	COG3121	Chaperone
I9192_06060	COG3188	usher protein
I9192_06070	COG0583	DNA-binding transcription factor activity
I9192_06080	COG0583	DNA-binding transcription factor activity
I9192_06095	COG0789	Transcriptional regulator
I9192_06115	COG2217	Heavy metal translocating P-type atpase
I9192_06120	COG2205	protein histidine kinase activity
I9192_06135	COG1923	regulation of RNA biosynthetic process
I9192_06145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I9192_06150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I9192_06160	COG2205	protein histidine kinase activity
I9192_06165	COG0745	RESPONSE REGULATOR receiver
I9192_06180	COG2832	Protein of unknown function (DUF454)
I9192_06190	COG1595	DNA-templated transcription, initiation
I9192_06235	COG1629	transport
I9192_06275	COG0006	proline dipeptidase activity
I9192_06285	COG4771	TonB-dependent receptor
I9192_06290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_06295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_06345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9192_06350	COG1388	LysM domain
I9192_06350	COG0741	lytic transglycosylase activity
I9192_06355	COG4166	transmembrane transport
I9192_06360	COG4174	ABC transporter (Permease)
I9192_06365	COG4239	(ABC) transporter, permease
I9192_06370	COG4172	Belongs to the ABC transporter superfamily
I9192_06390	COG0024	Methionine aminopeptidase
I9192_06395	COG0052	Belongs to the universal ribosomal protein uS2 family
I9192_06400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I9192_06450	COG2951	lytic endotransglycosylase activity
I9192_06455	COG0772	Belongs to the SEDS family
I9192_06470	COG0842	Transport permease protein
I9192_06475	COG1131	(ABC) transporter
I9192_06485	COG0582	viral genome integration into host DNA
I9192_06580	COG0305	Participates in initiation and elongation during chromosome replication
I9192_06660	COG5410	chromosome segregation
I9192_06785	COG3772	lysozyme
I9192_06800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I9192_06865	COG0305	Participates in initiation and elongation during chromosome replication
I9192_06910	COG2826	transposase and inactivated derivatives, IS30 family
I9192_06930	COG0673	inositol 2-dehydrogenase activity
I9192_06935	COG1324	tolerance protein
I9192_06960	COG2826	transposase and inactivated derivatives, IS30 family
I9192_06970	COG3620	sequence-specific DNA binding
I9192_07030	COG5410	chromosome segregation
I9192_07035	COG3567	Phage-associated protein, HI1409 family
I9192_07055	COG3566	protein conserved in bacteria
I9192_07170	COG0582	viral genome integration into host DNA
I9192_07220	COG1476	TRANSCRIPTIONal
I9192_07275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9192_07290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I9192_07300	COG2233	PERMEase
I9192_07310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_07315	COG1823	symporter activity
I9192_07335	COG0612	Peptidase, M16
I9192_07360	COG1720	tRNA m6t6A37 methyltransferase activity
I9192_07365	COG3025	triphosphatase activity
I9192_07380	COG0352	thiamine-phosphate diphosphorylase activity
I9192_07425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I9192_07430	COG3111	PFAM Bacterial OB fold (BOF) protein
I9192_07440	COG0642	Histidine kinase
I9192_07450	COG0494	nUDIX hydrolase
I9192_07460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9192_07465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I9192_07470	COG3139	Protein of unknown function (DUF1315)
I9192_07480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9192_07485	COG1301	dicarboxylic acid transport
I9192_07490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I9192_07500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I9192_07550	COG5377	YqaJ viral recombinase family
I9192_07590	COG4197	protein conserved in bacteria, prophage-related
I9192_07825	COG2318	DinB family
I9192_07830	COG2070	2-Nitropropane dioxygenase
I9192_07860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I9192_07885	COG1643	Atp-dependent helicase
I9192_07925	COG2831	hemolysin activation secretion protein
I9192_07930	COG2188	Transcriptional regulator
I9192_07950	COG1113	amino acid transport
I9192_07960	COG0010	Belongs to the arginase family
I9192_07965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9192_07985	COG2072	flavoprotein involved in K transport
I9192_08010	COG1136	(ABC) transporter
I9192_08015	COG0658	competence protein
I9192_08015	COG2333	competence protein COMEC
I9192_08035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I9192_08045	COG0628	permease
I9192_08085	COG3634	alkyl hydroperoxide reductase activity
I9192_08090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I9192_08095	COG0583	DNA-binding transcription factor activity
I9192_08100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9192_08105	COG0826	peptidase U32
I9192_08115	COG0640	Transcriptional regulator
I9192_08120	COG0798	PFAM Bile acid sodium symporter
I9192_08125	COG0789	Transcriptional regulator
I9192_08170	COG1022	Amp-dependent synthetase and ligase
I9192_08185	COG1309	transcriptional regulator
I9192_08215	COG4772	TonB-dependent receptor
I9192_08225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I9192_08230	COG0076	glutamate decarboxylase activity
I9192_08240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I9192_08275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I9192_08290	COG0642	Histidine kinase
I9192_08295	COG0745	RESPONSE REGULATOR receiver
I9192_08380	COG0583	DNA-binding transcription factor activity
I9192_08395	COG2995	paraquat-inducible protein a
I9192_08400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9192_08400	COG3008	intermembrane lipid transfer
I9192_08430	COG0693	protein deglycase activity
I9192_08450	COG5487	UPF0391 membrane protein
I9192_08460	COG1309	transcriptional regulator
I9192_08465	COG2814	Major facilitator Superfamily
I9192_08480	COG0477	Major facilitator Superfamily
I9192_08485	COG1309	transcriptional regulator
I9192_08490	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_08490	COG0604	alcohol dehydrogenase
I9192_08490	COG3321	synthase
I9192_08510	COG1785	Belongs to the alkaline phosphatase family
I9192_08525	COG1454	alcohol dehydrogenase
I9192_08530	COG2610	gluconate transmembrane transporter activity
I9192_08540	COG2814	Major facilitator Superfamily
I9192_08545	COG2207	Transcriptional regulator
I9192_08545	COG3708	Transcriptional regulator
I9192_08565	COG0154	amidase activity
I9192_08590	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_08600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_08610	COG0583	DNA-binding transcription factor activity
I9192_08625	COG0642	Histidine kinase
I9192_08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_08685	COG2271	Major facilitator Superfamily
I9192_08695	COG2267	carboxylic ester hydrolase activity
I9192_08700	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_08715	COG0028	Belongs to the TPP enzyme family
I9192_08750	COG0477	Major facilitator Superfamily
I9192_08760	COG2223	nitrite transmembrane transporter activity
I9192_08770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_08790	COG0436	Aminotransferase
I9192_08805	COG3300	MHYT domain
I9192_08805	COG5001	Diguanylate cyclase
I9192_08815	COG0556	nucleotide-excision repair
I9192_08825	COG2962	Rard protein
I9192_08860	COG0702	epimerase
I9192_08865	COG1733	regulation of RNA biosynthetic process
I9192_08880	COG2915	High frequency lysogenization protein hflD homolog
I9192_08915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9192_08920	COG1686	Belongs to the peptidase S11 family
I9192_08935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I9192_08940	COG4942	peptidase
I9192_08950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9192_08955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I9192_08960	COG1067	ATP-dependent peptidase activity
I9192_08995	COG1509	lysine 2,3-aminomutase activity
I9192_09000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I9192_09005	COG1966	Carbon starvation protein
I9192_09010	COG2879	small protein
I9192_09020	COG0714	Associated with various cellular activities
I9192_09040	COG0582	viral genome integration into host DNA
I9192_09070	COG4771	TonB-dependent receptor
I9192_09105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_09120	COG2252	PERMEase
I9192_09125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I9192_09135	COG3038	cytochrome b561
I9192_09145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I9192_09155	COG0527	aspartate kinase activity
I9192_09175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I9192_09195	COG1522	sequence-specific DNA binding
I9192_09200	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I9192_09205	COG1522	sequence-specific DNA binding
I9192_09210	COG1335	isochorismatase
I9192_09225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I9192_09245	COG0667	Aldo Keto reductase
I9192_09255	COG1765	OsmC-like protein
I9192_09265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I9192_09270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9192_09280	COG1045	serine acetyltransferase
I9192_09290	COG0542	response to heat
I9192_09330	COG3293	Transposase
I9192_09350	COG0540	Belongs to the ATCase OTCase family
I9192_09380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9192_09390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I9192_09400	COG0583	DNA-binding transcription factor activity
I9192_09420	COG3340	Belongs to the peptidase S51 family
I9192_09445	COG1309	transcriptional regulator
I9192_09450	COG2826	transposase and inactivated derivatives, IS30 family
I9192_09465	COG0204	Acyl-transferase
I9192_09480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I9192_09490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I9192_09510	COG0477	Major facilitator Superfamily
I9192_09515	COG0729	surface antigen
I9192_09535	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_09555	COG4783	chaperone-mediated protein folding
I9192_09570	COG1610	YqeY-like protein
I9192_09600	COG0436	Aminotransferase
I9192_09605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9192_09610	COG0386	Belongs to the glutathione peroxidase family
I9192_09615	COG2207	Transcriptional regulator
I9192_09615	COG1917	Cupin 2, conserved barrel domain protein
I9192_09665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I9192_09685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I9192_09710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9192_09740	COG0012	GTP binding
I9192_09745	COG2011	ABC-type metal ion transport system permease component
I9192_09750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9192_09755	COG1464	Belongs to the NlpA lipoprotein family
I9192_09760	COG1464	Belongs to the NlpA lipoprotein family
I9192_09830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9192_09865	COG2707	UPF0756 membrane protein
I9192_09870	COG1959	2 iron, 2 sulfur cluster binding
I9192_09875	COG0492	ferredoxin-NADP+ reductase activity
I9192_09880	COG1187	pseudouridine synthase activity
I9192_09900	COG0802	atpase or kinase
I9192_09905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I9192_09915	COG1923	regulation of RNA biosynthetic process
I9192_09955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9192_09965	COG3178	'Phosphotransferase
I9192_09970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I9192_09980	COG1192	Involved in chromosome partitioning
I9192_09985	COG1475	DNA binding
I9192_09990	COG0811	peptide transport
I9192_10000	COG1132	(ABC) transporter
I9192_10005	COG1663	tetraacyldisaccharide 4'-kinase activity
I9192_10025	COG0084	hydrolase, TatD family'
I9192_10050	COG3156	type II secretion system protein K
I9192_10060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I9192_10070	COG0590	tRNA wobble adenosine to inosine editing
I9192_10080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I9192_10115	COG0284	orotidine-5'-phosphate decarboxylase activity
I9192_10120	COG2431	L-lysine efflux transmembrane transporter activity
I9192_10135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I9192_10140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I9192_10145	COG0569	domain protein
I9192_10160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9192_10165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I9192_10200	COG3706	GGDEF domain
I9192_10215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I9192_10220	COG0542	response to heat
I9192_10225	COG0657	acetylesterase activity
I9192_10225	COG2755	lipolytic protein G-D-S-L family
I9192_10250	COG0583	DNA-binding transcription factor activity
I9192_10255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9192_10265	COG0583	DNA-binding transcription factor activity
I9192_10270	COG1960	acyl-CoA dehydrogenase activity
I9192_10275	COG2814	Major facilitator Superfamily
I9192_10325	COG0372	Belongs to the citrate synthase family
I9192_10330	COG1535	isochorismatase
I9192_10330	COG3433	isochorismatase activity
I9192_10350	COG0069	glutamate synthase activity
I9192_10365	COG2850	peptidyl-arginine hydroxylation
I9192_10370	COG0424	maF-like protein
I9192_10380	COG0126	phosphoglycerate kinase activity
I9192_10405	COG3196	Protein conserved in bacteria
I9192_10430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I9192_10440	COG0702	epimerase
I9192_10445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I9192_10475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I9192_10505	COG0316	Belongs to the HesB IscA family
I9192_10510	COG0822	iron-sulfur transferase activity
I9192_10520	COG1959	2 iron, 2 sulfur cluster binding
I9192_10535	COG0776	regulation of translation
I9192_10545	COG2207	Transcriptional regulator
I9192_10550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_10580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I9192_10585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9192_10615	COG1733	regulation of RNA biosynthetic process
I9192_10975	COG0583	DNA-binding transcription factor activity
I9192_10980	COG1380	Effector of murein hydrolase LrgA
I9192_10985	COG1346	cytolysis
I9192_10990	COG2814	Major facilitator Superfamily
I9192_11010	COG0596	Alpha beta hydrolase
I9192_11015	COG1448	Aminotransferase
I9192_11020	COG0488	(ABC) transporter
I9192_11055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I9192_11060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9192_11070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9192_11075	COG0697	spore germination
I9192_11125	COG0583	DNA-binding transcription factor activity
I9192_11150	COG3152	Membrane
I9192_11160	COG1294	oxidase, subunit
I9192_11165	COG1271	oxidase subunit
I9192_11175	COG2207	Transcriptional regulator
I9192_11180	COG1960	acyl-CoA dehydrogenase activity
I9192_11215	COG0583	DNA-binding transcription factor activity
I9192_11220	COG2814	Major facilitator Superfamily
I9192_11230	COG4774	siderophore transport
I9192_11240	COG3293	Transposase
I9192_11250	COG2207	Transcriptional regulator
I9192_11255	COG1881	PFAM PEBP family protein
I9192_11270	COG0477	Major facilitator Superfamily
I9192_11280	COG1024	Enoyl-CoA hydratase
I9192_11285	COG1960	acyl-CoA dehydrogenase activity
I9192_11290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9192_11310	COG1944	ATP diphosphatase activity
I9192_11325	COG0583	DNA-binding transcription factor activity
I9192_11330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_11335	COG4266	Belongs to the allantoicase family
I9192_11340	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I9192_11350	COG2351	hydroxyisourate hydrolase activity
I9192_11380	COG0804	urea catabolic process
I9192_11395	COG0829	nickel cation binding
I9192_11405	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I9192_11410	COG0830	nickel cation binding
I9192_11420	COG0589	response to stress
I9192_11470	COG1960	acyl-CoA dehydrogenase activity
I9192_11475	COG1960	acyl-CoA dehydrogenase activity
I9192_11495	COG0509	glycine decarboxylation via glycine cleavage system
I9192_11520	COG3300	MHYT domain
I9192_11520	COG5001	Diguanylate cyclase
I9192_11550	COG0640	Transcriptional regulator
I9192_11565	COG3619	membrane
I9192_11570	COG3122	Protein conserved in bacteria
I9192_11585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I9192_11600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I9192_11640	COG2223	nitrite transmembrane transporter activity
I9192_11680	COG2826	transposase and inactivated derivatives, IS30 family
I9192_11695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9192_11700	COG2267	carboxylic ester hydrolase activity
I9192_11705	COG2453	phosphatase
I9192_11705	COG0671	phosphoesterase, PA-phosphatase related
I9192_11720	COG4589	Belongs to the CDS family
I9192_11775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I9192_11780	COG2937	Belongs to the GPAT DAPAT family
I9192_11785	COG2226	methyltransferase
I9192_11785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9192_11785	COG0596	Alpha beta hydrolase
I9192_11790	COG1309	transcriptional regulator
I9192_11820	COG0667	Aldo Keto reductase
I9192_11825	COG0583	DNA-binding transcription factor activity
I9192_11830	COG3293	Transposase
I9192_11880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9192_11885	COG0772	Belongs to the SEDS family
I9192_11895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I9192_11905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I9192_11940	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_11940	COG1902	pentaerythritol trinitrate reductase activity
I9192_11960	COG2814	Major facilitator Superfamily
I9192_11965	COG0583	DNA-binding transcription factor activity
I9192_11975	COG4638	Rieske (2fe-2S)
I9192_11980	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I9192_11985	COG0633	Ferredoxin
I9192_11985	COG0543	2 iron, 2 sulfur cluster binding
I9192_11990	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_11995	COG3135	benzoate transporter
I9192_12025	COG0477	Major facilitator Superfamily
I9192_12035	COG3293	Transposase
I9192_12050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I9192_12060	COG1027	Aspartate ammonia-lyase
I9192_12065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9192_12120	COG0308	aminopeptidase N
I9192_12135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I9192_12145	COG1846	Transcriptional regulator
I9192_12185	COG0511	ligase activity, forming carbon-carbon bonds
I9192_12190	COG0439	Biotin carboxylase
I9192_12220	COG0730	response to heat
I9192_12225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I9192_12245	COG1218	3'(2'),5'-bisphosphate nucleotidase
I9192_12255	COG1011	Hydrolase
I9192_12260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I9192_12265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I9192_12270	COG4221	oxidoreductase activity
I9192_12275	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_12280	COG2137	regulation of response to DNA damage stimulus
I9192_12300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9192_12310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9192_12320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9192_12335	COG0575	Belongs to the CDS family
I9192_12340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I9192_12345	COG0233	cytoplasmic translational termination
I9192_12360	COG3852	Histidine kinase
I9192_12375	COG3753	Protein conserved in bacteria
I9192_12390	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9192_12395	COG4773	Receptor
I9192_12415	COG1304	FMN binding
I9192_12420	COG1132	(ABC) transporter
I9192_12425	COG1846	Transcriptional regulator
I9192_12440	COG2153	protein acetylation
I9192_12445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I9192_12475	COG1294	oxidase, subunit
I9192_12480	COG4890	Cyd operon protein YbgT
I9192_12535	COG2194	sulfuric ester hydrolase activity
I9192_12540	COG2119	membrane
I9192_12545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9192_12565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I9192_12575	COG3135	benzoate transporter
I9192_12580	COG0024	Methionine aminopeptidase
I9192_12585	COG1114	Component of the transport system for branched-chain amino acids
I9192_12605	COG1253	flavin adenine dinucleotide binding
I9192_12625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I9192_12635	COG0552	protein localization to endoplasmic reticulum
I9192_12640	COG0612	Peptidase, M16
I9192_12670	COG0517	IMP dehydrogenase activity
I9192_12670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9192_12680	COG0133	tryptophan synthase activity
I9192_12690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9192_12710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I9192_12740	COG0537	adenosine 5'-monophosphoramidase activity
I9192_12805	COG1454	alcohol dehydrogenase
I9192_12820	COG0824	Thioesterase
I9192_12865	COG0183	Belongs to the thiolase family
I9192_12875	COG1454	alcohol dehydrogenase
I9192_12890	COG3284	Transcriptional regulator
I9192_12910	COG0583	DNA-binding transcription factor activity
I9192_12930	COG1309	transcriptional regulator
I9192_12935	COG0519	Catalyzes the synthesis of GMP from XMP
I9192_12935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9192_12940	COG3042	response to heat
I9192_12950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9192_12960	COG2353	YceI-like domain
I9192_12975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I9192_12995	COG1280	lysine exporter protein (LysE YggA)
I9192_13025	COG1254	Belongs to the acylphosphatase family
I9192_13030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I9192_13030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I9192_13060	COG0167	dihydroorotate dehydrogenase activity
I9192_13085	COG0778	Nitroreductase
I9192_13095	COG0513	Belongs to the DEAD box helicase family
I9192_13115	COG2363	Small membrane protein
I9192_13145	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I9192_13150	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9192_13160	COG0659	secondary active sulfate transmembrane transporter activity
I9192_13170	COG4585	Histidine kinase
I9192_13180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9192_13185	COG1960	acyl-CoA dehydrogenase activity
I9192_13205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_13210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9192_13215	COG3781	membrane
I9192_13220	COG2890	protein-(glutamine-N5) methyltransferase activity
I9192_13240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_13245	COG4682	membrane
I9192_13275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I9192_13280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I9192_13285	COG1845	cytochrome c oxidase, subunit III
I9192_13290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I9192_13310	COG0360	Binds together with S18 to 16S ribosomal RNA
I9192_13315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I9192_13325	COG0305	Participates in initiation and elongation during chromosome replication
I9192_13335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I9192_13355	COG1305	Transglutaminase-like
I9192_13365	COG2308	Evidence 4 Homologs of previously reported genes of
I9192_13405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I9192_13410	COG0138	bifunctional purine biosynthesis protein purh
I9192_13415	COG0151	Belongs to the GarS family
I9192_13425	COG1464	Belongs to the NlpA lipoprotein family
I9192_13430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9192_13435	COG2011	ABC-type metal ion transport system permease component
I9192_13445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9192_13540	COG3022	response to hydroperoxide
I9192_13550	COG4650	regulator
I9192_13555	COG1234	tRNA 3'-trailer cleavage
I9192_13565	COG1690	Belongs to the RtcB family
I9192_13575	COG0430	RNA-3'-phosphate cyclase activity
I9192_13595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I9192_13605	COG0693	protein deglycase activity
I9192_13615	COG1960	acyl-CoA dehydrogenase activity
I9192_13620	COG0616	signal peptide processing
I9192_13625	COG3293	Transposase
I9192_13630	COG1301	dicarboxylic acid transport
I9192_13635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I9192_13645	COG0573	inorganic phosphate transmembrane transporter activity
I9192_13660	COG4122	O-methyltransferase activity
I9192_13685	COG1137	ATPase activity
I9192_13690	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I9192_13700	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I9192_13705	COG0517	IMP dehydrogenase activity
I9192_13705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9192_13715	COG0427	acetyl-CoA hydrolase
I9192_13720	COG0183	Belongs to the thiolase family
I9192_13725	COG1960	acyl-CoA dehydrogenase activity
I9192_13775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I9192_13800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_13815	COG1301	dicarboxylic acid transport
I9192_13840	COG0047	phosphoribosylformylglycinamidine synthase activity
I9192_13840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I9192_13875	COG4771	TonB-dependent receptor
I9192_13910	COG0824	Thioesterase
I9192_13940	COG0823	Involved in the tonB-independent uptake of proteins
I9192_13965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9192_13985	COG0174	glutamine synthetase
I9192_14055	COG0512	Glutamine amidotransferase of anthranilate synthase
I9192_14060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9192_14080	COG0302	gtp cyclohydrolase
I9192_14110	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_14115	COG1960	acyl-CoA dehydrogenase activity
I9192_14120	COG4302	ethanolamine ammonia-lyase activity
I9192_14125	COG4303	Ethanolamine ammonia lyase large subunit
I9192_14130	COG0531	amino acid
I9192_14150	COG3739	integral membrane protein
I9192_14165	COG1741	Belongs to the pirin family
I9192_14170	COG0235	Class ii aldolase
I9192_14185	COG2233	PERMEase
I9192_14190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_14195	COG0251	oxidation-reduction process
I9192_14200	COG1335	isochorismatase
I9192_14205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_14215	COG0596	Alpha beta hydrolase
I9192_14265	COG0864	Transcriptional regulator
I9192_14270	COG1733	regulation of RNA biosynthetic process
I9192_14275	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9192_14280	COG0439	Biotin carboxylase
I9192_14300	COG0583	DNA-binding transcription factor activity
I9192_14305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I9192_14315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9192_14320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I9192_14325	COG4149	molybdate abc transporter
I9192_14330	COG0725	ABC transporter, periplasmic molybdate-binding protein
I9192_14335	COG0303	'Molybdopterin
I9192_14340	COG0521	Mo-molybdopterin cofactor biosynthetic process
I9192_14340	COG0315	cyclic pyranopterin monophosphate synthase activity
I9192_14345	COG0314	molybdopterin synthase activity
I9192_14355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I9192_14365	COG0243	molybdopterin cofactor binding
I9192_14370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_14375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_14375	COG2146	nitrite reductase [NAD(P)H] activity
I9192_14380	COG2223	nitrite transmembrane transporter activity
I9192_14390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_14390	COG1116	anion transmembrane transporter activity
I9192_14395	COG4774	siderophore transport
I9192_14400	COG1846	Transcriptional regulator
I9192_14445	COG3121	Chaperone
I9192_14450	COG3539	Fimbrial protein
I9192_14470	COG1113	amino acid transport
I9192_14480	COG1012	belongs to the aldehyde dehydrogenase family
I9192_14485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I9192_14570	COG2072	flavoprotein involved in K transport
I9192_14590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I9192_14595	COG1012	belongs to the aldehyde dehydrogenase family
I9192_14645	COG2826	transposase and inactivated derivatives, IS30 family
I9192_14665	COG2826	transposase and inactivated derivatives, IS30 family
I9192_14670	COG3210	domain, Protein
I9192_14670	COG3210	domain, Protein
I9192_14675	COG2831	hemolysin activation secretion protein
I9192_14690	COG0582	viral genome integration into host DNA
I9192_14725	COG1230	cation diffusion facilitator family transporter
I9192_14740	COG2814	Major facilitator Superfamily
I9192_14840	COG1902	pentaerythritol trinitrate reductase activity
I9192_14840	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_14850	COG0277	FAD linked oxidase domain protein
I9192_14860	COG2186	Transcriptional regulator
I9192_14870	COG0697	spore germination
I9192_14875	COG0583	DNA-binding transcription factor activity
I9192_14915	COG1960	acyl-CoA dehydrogenase activity
I9192_14950	COG0154	amidase activity
I9192_14970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I9192_14980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9192_14990	COG0280	phosphate acetyltransferase
I9192_14990	COG0281	malic enzyme
I9192_15025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I9192_15030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9192_15035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9192_15050	COG2351	hydroxyisourate hydrolase activity
I9192_15060	COG1686	Belongs to the peptidase S11 family
I9192_15065	COG1252	NADH dehydrogenase
I9192_15070	COG1047	Peptidyl-prolyl cis-trans
I9192_15075	COG0415	Belongs to the DNA photolyase family
I9192_15090	COG0583	DNA-binding transcription factor activity
I9192_15095	COG0251	oxidation-reduction process
I9192_15105	COG0667	Aldo Keto reductase
I9192_15115	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I9192_15130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I9192_15135	COG0571	ribonuclease III activity
I9192_15160	COG0463	Glycosyl transferase, family 2
I9192_15165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I9192_15170	COG0671	phosphoesterase, PA-phosphatase related
I9192_15180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9192_15220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I9192_15225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I9192_15230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I9192_15240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I9192_15245	COG4208	sulfate ABC transporter
I9192_15250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I9192_15255	COG0583	DNA-binding transcription factor activity
I9192_15275	COG0602	queuosine metabolic process
I9192_15280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I9192_15295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9192_15305	COG0583	DNA-binding transcription factor activity
I9192_15315	COG0625	glutathione transferase activity
I9192_15330	COG1056	cytidyltransferase-related domain
I9192_15330	COG1051	belongs to the nudix hydrolase family
I9192_15335	COG1024	Enoyl-CoA hydratase
I9192_15340	COG0778	Nitroreductase
I9192_15345	COG3323	Protein of unknown function (DUF1653)
I9192_15345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9192_15390	COG1280	lysine exporter protein (LysE YggA)
I9192_15395	COG1522	sequence-specific DNA binding
I9192_15420	COG2234	aminopeptidase activity
I9192_15430	COG3384	dioxygenase
I9192_15445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9192_15450	COG2878	Part of a membrane complex involved in electron transport
I9192_15455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I9192_15485	COG0768	penicillin binding
I9192_15490	COG0742	ribosomal rna small subunit methyltransferase
I9192_15510	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_15515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I9192_15525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9192_15540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I9192_15545	COG1053	succinate dehydrogenase
I9192_15550	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I9192_15555	COG2009	succinate dehydrogenase
I9192_15590	COG2072	flavoprotein involved in K transport
I9192_15595	COG0300	oxidoreductase activity
I9192_15620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9192_15620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I9192_15640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I9192_15645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9192_15650	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I9192_15670	COG0505	Belongs to the CarA family
I9192_15675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I9192_15685	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I9192_15695	COG1113	amino acid transport
I9192_15705	COG0625	glutathione transferase activity
I9192_15720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_15740	COG1024	Enoyl-CoA hydratase
I9192_15765	COG2321	neutral zinc metallopeptidase
I9192_15770	COG2354	Protein conserved in bacteria
I9192_15800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I9192_15805	COG1773	rubredoxin
I9192_15810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_15820	COG0583	DNA-binding transcription factor activity
I9192_15835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9192_15845	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I9192_15850	COG4181	ATPase activity
I9192_15875	COG2357	RelA SpoT domain protein
I9192_15970	COG1783	phage Terminase large subunit
I9192_16015	COG0305	Participates in initiation and elongation during chromosome replication
I9192_16105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I9192_16120	COG0424	maF-like protein
I9192_16125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I9192_16130	COG1792	Involved in formation and maintenance of cell shape
I9192_16135	COG1077	Cell shape determining protein MreB Mrl
I9192_16140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9192_16150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9192_16170	COG2318	DinB family
I9192_16185	COG3590	peptidase
I9192_16190	COG0583	DNA-binding transcription factor activity
I9192_16220	COG0583	DNA-binding transcription factor activity
I9192_16225	COG4948	Mandelate Racemase Muconate Lactonizing
I9192_16230	COG4829	muconolactone delta-isomerase
I9192_16240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9192_16245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_16250	COG0183	Belongs to the thiolase family
I9192_16255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9192_16290	COG2871	sodium ion transport
I9192_16305	COG0789	Transcriptional regulator
I9192_16315	COG4221	oxidoreductase activity
I9192_16320	COG1902	pentaerythritol trinitrate reductase activity
I9192_16320	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_16330	COG0523	cobalamin synthesis protein
I9192_16345	COG3539	Fimbrial protein
I9192_16375	COG3539	Fimbrial protein
I9192_16390	COG3539	Fimbrial protein
I9192_16400	COG3121	Chaperone
I9192_16415	COG3539	Fimbrial protein
I9192_16435	COG1012	belongs to the aldehyde dehydrogenase family
I9192_16440	COG4638	Rieske (2fe-2S)
I9192_16445	COG0657	acetylesterase activity
I9192_16455	COG0473	3-isopropylmalate dehydrogenase activity
I9192_16460	COG0583	DNA-binding transcription factor activity
I9192_16480	COG1063	alcohol dehydrogenase
I9192_16490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9192_16495	COG0508	dehydrogenase complex catalyzes the overall conversion of
I9192_16500	COG0022	dehydrogenase e1 component
I9192_16505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I9192_16510	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9192_16520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9192_16525	COG3135	benzoate transporter
I9192_16535	COG5002	protein histidine kinase activity
I9192_16545	COG0745	RESPONSE REGULATOR receiver
I9192_16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_16555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_16575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I9192_16650	COG0505	Belongs to the CarA family
I9192_16655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9192_16665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I9192_16670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_16675	COG3706	GGDEF domain
I9192_16695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9192_16700	COG1012	belongs to the aldehyde dehydrogenase family
I9192_16710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9192_16715	COG1012	belongs to the aldehyde dehydrogenase family
I9192_16720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_16725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_16730	COG2267	carboxylic ester hydrolase activity
I9192_16750	COG4774	siderophore transport
I9192_16755	COG4607	ABC-type enterochelin transport system periplasmic component
I9192_16760	COG4604	ABC transporter, ATP-binding protein
I9192_16765	COG4605	iron ion homeostasis
I9192_16770	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I9192_16780	COG1132	(ABC) transporter
I9192_16780	COG2375	cellular response to nickel ion
I9192_16795	COG0789	Transcriptional regulator
I9192_16810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_16815	COG2771	luxR family
I9192_16835	COG1733	regulation of RNA biosynthetic process
I9192_16840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_16845	COG1414	Transcriptional regulator
I9192_16860	COG2985	domain, Protein
I9192_16875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9192_16880	COG3328	transposase activity
I9192_16885	COG0431	NADPH-dependent FMN reductase
I9192_16890	COG0798	PFAM Bile acid sodium symporter
I9192_16900	COG0640	Transcriptional regulator
I9192_16925	COG1595	DNA-templated transcription, initiation
I9192_16935	COG3220	belongs to the UPF0276 family
I9192_16960	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I9192_16995	COG4774	siderophore transport
I9192_17005	COG1802	Transcriptional regulator
I9192_17030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9192_17125	COG0582	viral genome integration into host DNA
I9192_17135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I9192_17140	COG0242	peptide deformylase activity
I9192_17145	COG0477	Major facilitator Superfamily
I9192_17150	COG3706	GGDEF domain
I9192_17165	COG1585	Membrane protein implicated in regulation of membrane protease activity
I9192_17170	COG2268	Band 7 protein
I9192_17180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9192_17185	COG1309	transcriptional regulator
I9192_17205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I9192_17210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I9192_17225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I9192_17240	COG4166	transmembrane transport
I9192_17245	COG4166	transmembrane transport
I9192_17275	COG0590	tRNA wobble adenosine to inosine editing
I9192_17280	COG2824	Alkylphosphonate utilization operon protein PhnA
I9192_17310	COG1408	metallophosphoesterase
I9192_17315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9192_17325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I9192_17365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9192_17370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I9192_17375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I9192_17385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I9192_17390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I9192_17400	COG0625	glutathione transferase activity
I9192_17405	COG2969	positive regulation of protein catabolic process
I9192_17430	COG3447	MASE1 domain protein
I9192_17430	COG5001	Diguanylate cyclase
I9192_17430	COG5002	protein histidine kinase activity
I9192_17470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I9192_17475	COG0354	folic acid binding
I9192_17490	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9192_17540	COG1902	pentaerythritol trinitrate reductase activity
I9192_17545	COG4772	TonB-dependent receptor
I9192_17550	COG3659	wide pore channel activity
I9192_17560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9192_17575	COG1970	mechanosensitive ion channel activity
I9192_17580	COG1217	gtp-binding protein TYPA
I9192_17585	COG2233	PERMEase
I9192_17595	COG0833	amino acid
I9192_17600	COG1690	Belongs to the RtcB family
I9192_17625	COG0183	Belongs to the thiolase family
I9192_17680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9192_17685	COG0523	cobalamin synthesis protein
I9192_17700	COG0204	Acyl-transferase
I9192_17715	COG1280	lysine exporter protein (LysE YggA)
I9192_17720	COG0531	amino acid
I9192_17720	COG1674	ftsk spoiiie
I9192_17725	COG0492	ferredoxin-NADP+ reductase activity
I9192_17730	COG0500	methyltransferase
I9192_17735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I9192_17745	COG0456	acetyltransferase
I9192_17770	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I9192_17780	COG0714	Associated with various cellular activities
I9192_17790	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I9192_17800	COG3831	ATPase activity
I9192_17810	COG1981	membrane
I9192_17820	COG1113	amino acid transport
I9192_17825	COG0251	oxidation-reduction process
I9192_17850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9192_17850	COG0351	phosphomethylpyrimidine kinase
I9192_17850	COG0352	thiamine-phosphate diphosphorylase activity
I9192_17865	COG1280	lysine exporter protein (LysE YggA)
I9192_17870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I9192_17880	COG2076	Multidrug Resistance protein
I9192_17895	COG2132	Multicopper oxidase
I9192_17905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I9192_17915	COG4269	membrane
I9192_17995	COG2826	transposase and inactivated derivatives, IS30 family
I9192_18020	COG1968	undecaprenyl-diphosphatase activity
I9192_18025	COG1214	PFAM Peptidase M22, glycoprotease
I9192_18030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9192_18035	COG0494	nUDIX hydrolase
I9192_18090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I9192_18100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I9192_18125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9192_18130	COG0765	amino acid transport
I9192_18135	COG0765	amino acid transport
I9192_18140	COG1126	abc transporter atp-binding protein
I9192_18165	COG4716	Myosin-crossreactive antigen
I9192_18180	COG2226	methyltransferase
I9192_18195	COG1309	transcriptional regulator
I9192_18210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I9192_18215	COG2081	HI0933 family
I9192_18230	COG0668	transmembrane transport
I9192_18245	COG2814	Major facilitator Superfamily
I9192_18250	COG1289	transmembrane transporter activity
I9192_18260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I9192_18315	COG2832	Protein of unknown function (DUF454)
I9192_18335	COG0793	Belongs to the peptidase S41A family
I9192_18360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I9192_18365	COG0280	phosphate acetyltransferase
I9192_18365	COG0857	belongs to the CobB CobQ family
I9192_18410	COG0740	serine-type endopeptidase activity
I9192_18420	COG4774	siderophore transport
I9192_18425	COG4774	siderophore transport
I9192_18430	COG3128	pkhd-type hydroxylase
I9192_18440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I9192_18450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9192_18450	COG2813	Specifically methylates the guanine in position
I9192_18475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I9192_18490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9192_18530	COG3878	Protein conserved in bacteria
I9192_18535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I9192_18595	COG2199	diguanylate cyclase activity
I9192_18630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I9192_18645	COG0450	alkyl hydroperoxide reductase
I9192_18650	COG1652	LysM domain
I9192_18655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9192_18660	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_18675	COG1399	metal-binding, possibly nucleic acid-binding protein
I9192_18680	COG3101	peptidyl-lysine hydroxylation
I9192_18685	COG0009	L-threonylcarbamoyladenylate synthase
I9192_18690	COG3713	MltA-interacting MipA family protein
I9192_18710	COG0285	dihydrofolate synthase activity
I9192_18715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I9192_18755	COG0183	Belongs to the thiolase family
I9192_18765	COG0456	acetyltransferase
I9192_18770	COG0454	-acetyltransferase
I9192_18775	COG2207	Transcriptional regulator
I9192_18780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I9192_18795	COG1051	belongs to the nudix hydrolase family
I9192_18810	COG3422	double-strand break repair
I9192_18825	COG4106	trans-aconitate 2-methyltransferase activity
I9192_18840	COG2267	carboxylic ester hydrolase activity
I9192_18850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9192_18860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I9192_18875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I9192_18885	COG1196	nuclear chromosome segregation
I9192_18895	COG0730	response to heat
I9192_18910	COG0625	glutathione transferase activity
I9192_18915	COG3545	Serine hydrolase
I9192_18920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I9192_18930	COG3293	Transposase
I9192_18935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9192_19040	COG1011	Hydrolase
I9192_19045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9192_19065	COG1272	protein, Hemolysin III
I9192_19070	COG0477	Major facilitator Superfamily
I9192_19075	COG0564	pseudouridine synthase activity
I9192_19080	COG4770	biotin carboxylase activity
I9192_19085	COG1024	Enoyl-CoA hydratase
I9192_19090	COG1960	acyl-CoA dehydrogenase activity
I9192_19095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I9192_19100	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_19120	COG1960	acyl-CoA dehydrogenase activity
I9192_19125	COG1960	acyl-CoA dehydrogenase activity
I9192_19130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9192_19170	COG1183	phosphatidylcholine synthase activity
I9192_19175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I9192_19195	COG0039	L-malate dehydrogenase activity
I9192_19205	COG0739	heme binding
I9192_19205	COG0741	lytic transglycosylase activity
I9192_19205	COG1196	nuclear chromosome segregation
I9192_19210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I9192_19215	COG1702	phosphate starvation-inducible protein PhoH
I9192_19225	COG0613	PHP domain protein
I9192_19235	COG2350	Protein conserved in bacteria
I9192_19250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I9192_19255	COG1666	GTP binding
I9192_19270	COG1607	acyl-coa hydrolase
I9192_19295	COG0402	S-adenosylhomocysteine deaminase activity
I9192_19300	COG2267	carboxylic ester hydrolase activity
I9192_19305	COG0179	Fumarylacetoacetate (FAA) hydrolase
I9192_19340	COG0788	formyltetrahydrofolate deformylase activity
I9192_19365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I9192_19365	COG4651	solute:proton antiporter activity
I9192_19390	COG1929	Belongs to the glycerate kinase type-1 family
I9192_19425	COG1733	regulation of RNA biosynthetic process
I9192_19430	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_19440	COG4770	biotin carboxylase activity
I9192_19460	COG1914	H( )-stimulated, divalent metal cation uptake system
I9192_19465	COG0583	DNA-binding transcription factor activity
I9192_19470	COG2900	Belongs to the SlyX family
I9192_19475	COG0488	(ABC) transporter
I9192_19520	COG1560	Kdo2-lipid A biosynthetic process
I9192_19555	COG0252	asparaginase activity
I9192_19570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I9192_19580	COG0473	3-isopropylmalate dehydrogenase activity
I9192_19595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I9192_19610	COG0583	DNA-binding transcription factor activity
I9192_19625	COG0494	nUDIX hydrolase
I9192_19650	COG1960	acyl-CoA dehydrogenase activity
I9192_19660	COG0753	catalase activity
I9192_19700	COG0583	DNA-binding transcription factor activity
I9192_19715	COG2378	regulation of single-species biofilm formation
I9192_19720	COG0546	phosphoglycolate phosphatase activity
I9192_19730	COG1530	ribonuclease E activity
I9192_19735	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_19765	COG1983	PspC domain protein
I9192_19770	COG0517	IMP dehydrogenase activity
I9192_19785	COG0277	FAD linked oxidase domain protein
I9192_19795	COG0752	glycyl-tRNA synthetase alpha subunit
I9192_19820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I9192_19865	COG2226	methyltransferase
I9192_19880	COG0628	permease
I9192_19885	COG2032	superoxide dismutase activity
I9192_19900	COG1289	transmembrane transporter activity
I9192_19910	COG2814	Major facilitator Superfamily
I9192_19935	COG1181	Belongs to the D-alanine--D-alanine ligase family
I9192_19950	COG0277	FAD linked oxidase domain protein
I9192_19955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I9192_19960	COG5006	permease, DMT superfamily
I9192_19970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9192_19995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I9192_20000	COG5380	lipid catabolic process
I9192_20005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9192_20015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9192_20020	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9192_20025	COG0335	large ribosomal subunit rRNA binding
I9192_20035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I9192_20040	COG0228	four-way junction DNA binding
I9192_20085	COG0194	GDP metabolic process
I9192_20090	COG1758	RNA polymerase activity
I9192_20095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9192_20115	COG3307	-O-antigen
I9192_20145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9192_20150	COG1704	LemA family
I9192_20155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I9192_20160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I9192_20165	COG0195	Participates in both transcription termination and antitermination
I9192_20170	COG0779	Required for maturation of 30S ribosomal subunits
I9192_20220	COG0237	dephospho-CoA kinase activity
I9192_20230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9192_20235	COG3123	guanosine phosphorylase activity
I9192_20240	COG0497	DNA recombination
I9192_20250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I9192_20270	COG1289	transmembrane transporter activity
I9192_20280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9192_20290	COG1132	(ABC) transporter
I9192_20310	COG4974	Belongs to the 'phage' integrase family
I9192_20325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I9192_20330	COG1686	Belongs to the peptidase S11 family
I9192_20335	COG2197	response regulator
I9192_20350	COG0793	Belongs to the peptidase S41A family
I9192_20355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I9192_20360	COG0795	lipopolysaccharide-transporting ATPase activity
I9192_20365	COG0795	lipopolysaccharide-transporting ATPase activity
I9192_20400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9192_20435	COG1024	Enoyl-CoA hydratase
I9192_20435	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9192_20440	COG0183	Belongs to the thiolase family
I9192_20475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I9192_20490	COG0326	Molecular chaperone. Has ATPase activity
I9192_20515	COG2056	Na+-H+ antiporter family
I9192_20545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I9192_20550	COG0085	RNA polymerase activity
I9192_20565	COG0081	regulation of translation
I9192_20580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I9192_20625	COG1716	ATPase activity
I9192_20670	COG0181	hydroxymethylbilane synthase activity
I9192_20680	COG2972	Histidine kinase
I9192_20680	COG0745	RESPONSE REGULATOR receiver
I9192_20685	COG0165	Argininosuccinate lyase
I9192_20705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I9192_20725	COG3158	transport of potassium into the cell
I9192_20775	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I9192_20785	COG1335	isochorismatase
I9192_20790	COG0583	DNA-binding transcription factor activity
I9192_20805	COG2207	Transcriptional regulator
I9192_20805	COG3708	Transcriptional regulator
I9192_20815	COG0629	single-stranded DNA binding
I9192_20820	COG2814	Major facilitator Superfamily
I9192_20830	COG0351	phosphomethylpyrimidine kinase
I9192_20830	COG0352	thiamine-phosphate diphosphorylase activity
I9192_20830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9192_20840	COG2814	Major facilitator Superfamily
I9192_20855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I9192_20860	COG2267	carboxylic ester hydrolase activity
I9192_20905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I9192_20910	COG0259	pyridoxamine-phosphate oxidase activity
I9192_20930	COG0426	domain, Protein
I9192_20930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_20935	COG2119	membrane
I9192_20975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I9192_20985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9192_20995	COG0189	ligase activity
I9192_21000	COG3385	transposase activity
I9192_21010	COG2226	methyltransferase
I9192_21015	COG2720	vancomycin resistance protein
I9192_21030	COG0708	Exodeoxyribonuclease III
I9192_21035	COG1393	Belongs to the ArsC family
I9192_21055	COG3706	GGDEF domain
I9192_21125	COG3150	esterase
I9192_21145	COG2918	glutathione biosynthetic process
I9192_21165	COG2733	membrane
I9192_21195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_21260	COG0436	Aminotransferase
I9192_21265	COG0534	Mate efflux family protein
I9192_21330	COG0560	Phosphoserine phosphatase
I9192_21330	COG3830	Belongs to the UPF0237 family
I9192_21345	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I9192_21355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I9192_21360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I9192_21370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I9192_21375	COG1230	cation diffusion facilitator family transporter
I9192_21380	COG0640	Transcriptional regulator
I9192_21395	COG1683	Conserved Protein
I9192_21400	COG0385	Bile acid
I9192_21405	COG1335	isochorismatase
I9192_21410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I9192_21435	COG0633	Ferredoxin
I9192_21460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I9192_21465	COG2819	hydrolase of the alpha beta superfamily
I9192_21470	COG2983	Belongs to the UPF0260 family
I9192_21475	COG5487	UPF0391 membrane protein
I9192_21490	COG1194	a g-specific adenine glycosylase
I9192_21495	COG0739	heme binding
I9192_21505	COG2818	Glycosylase
I9192_21510	COG1064	alcohol dehydrogenase
I9192_21525	COG0583	DNA-binding transcription factor activity
I9192_21530	COG0656	L-ascorbic acid biosynthetic process
I9192_21535	COG2814	Major facilitator Superfamily
I9192_21575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_21580	COG1309	transcriptional regulator
I9192_21585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I9192_21590	COG2233	PERMEase
I9192_21605	COG0196	riboflavin kinase activity
I9192_21610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I9192_21615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I9192_21620	COG1047	Peptidyl-prolyl cis-trans
I9192_21625	COG1794	racemase activity, acting on amino acids and derivatives
I9192_21640	COG0174	glutamine synthetase
I9192_21660	COG0129	dihydroxy-acid dehydratase activity
I9192_21675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I9192_21690	COG0733	neurotransmitter:sodium symporter activity
I9192_21695	COG3738	Protein conserved in bacteria
I9192_21700	COG1012	belongs to the aldehyde dehydrogenase family
I9192_21745	COG0737	Belongs to the 5'-nucleotidase family
I9192_21750	COG2175	clavaminate synthase activity
I9192_21755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9192_21760	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I9192_21765	COG4521	taurine ABC transporter
I9192_21785	COG0443	Heat shock 70 kDa protein
I9192_21825	COG2951	lytic endotransglycosylase activity
I9192_21830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I9192_21850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9192_21870	COG2388	GCN5-related N-acetyl-transferase
I9192_21875	COG2388	GCN5-related N-acetyl-transferase
I9192_21880	COG2814	Major facilitator Superfamily
I9192_21885	COG1335	isochorismatase
I9192_21890	COG0861	Integral membrane protein TerC family
I9192_21905	COG0754	glutathionylspermidine amidase activity
I9192_21915	COG0402	S-adenosylhomocysteine deaminase activity
I9192_21925	COG2261	transglycosylase associated protein
I9192_21935	COG1230	cation diffusion facilitator family transporter
I9192_21960	COG0706	membrane insertase activity
I9192_21965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I9192_21970	COG0594	ribonuclease P activity
I9192_22000	COG2801	Transposase and inactivated derivatives
I9192_22005	COG3173	Aminoglycoside phosphotransferase
I9192_22010	COG0488	(ABC) transporter
I9192_22015	COG2801	Transposase and inactivated derivatives
I9192_22030	COG2801	Transposase and inactivated derivatives
I9192_22035	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9192_22040	COG3657	addiction module killer protein
I9192_22055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I9192_22130	COG1475	DNA binding
I9192_22135	COG1192	Involved in chromosome partitioning
I9192_22170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I9192_22185	COG1570	exodeoxyribonuclease VII activity