locus-tag	class	description
I9190_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I9190_00010	COG0592	DNA-directed DNA polymerase activity
I9190_00020	COG0187	DNA topoisomerase II activity
I9190_00030	COG0488	(ABC) transporter
I9190_00040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I9190_00045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I9190_00050	COG0596	Alpha beta hydrolase
I9190_00070	COG0657	acetylesterase activity
I9190_00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I9190_00115	COG1012	belongs to the aldehyde dehydrogenase family
I9190_00120	COG3738	Protein conserved in bacteria
I9190_00125	COG0733	neurotransmitter:sodium symporter activity
I9190_00140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I9190_00155	COG0129	dihydroxy-acid dehydratase activity
I9190_00175	COG0174	glutamine synthetase
I9190_00190	COG1794	racemase activity, acting on amino acids and derivatives
I9190_00210	COG1047	Peptidyl-prolyl cis-trans
I9190_00215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I9190_00220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I9190_00225	COG0196	riboflavin kinase activity
I9190_00240	COG2233	PERMEase
I9190_00245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I9190_00250	COG1309	transcriptional regulator
I9190_00255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_00295	COG2814	Major facilitator Superfamily
I9190_00300	COG0656	L-ascorbic acid biosynthetic process
I9190_00305	COG0583	DNA-binding transcription factor activity
I9190_00320	COG1064	alcohol dehydrogenase
I9190_00325	COG2818	Glycosylase
I9190_00335	COG0739	heme binding
I9190_00340	COG1194	a g-specific adenine glycosylase
I9190_00355	COG5487	UPF0391 membrane protein
I9190_00360	COG2983	Belongs to the UPF0260 family
I9190_00365	COG2819	hydrolase of the alpha beta superfamily
I9190_00370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I9190_00395	COG0633	Ferredoxin
I9190_00420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I9190_00425	COG1335	isochorismatase
I9190_00430	COG0385	Bile acid
I9190_00435	COG1683	Conserved Protein
I9190_00450	COG0640	Transcriptional regulator
I9190_00455	COG1230	cation diffusion facilitator family transporter
I9190_00565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I9190_00575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I9190_00580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I9190_00590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I9190_00605	COG0560	Phosphoserine phosphatase
I9190_00605	COG3830	Belongs to the UPF0237 family
I9190_00670	COG0534	Mate efflux family protein
I9190_00675	COG0436	Aminotransferase
I9190_00730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_00760	COG2733	membrane
I9190_00780	COG2918	glutathione biosynthetic process
I9190_00800	COG3150	esterase
I9190_00875	COG3706	GGDEF domain
I9190_00895	COG1393	Belongs to the ArsC family
I9190_00900	COG0708	Exodeoxyribonuclease III
I9190_00915	COG2720	vancomycin resistance protein
I9190_00920	COG2226	methyltransferase
I9190_00930	COG0189	ligase activity
I9190_00940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9190_00950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I9190_00990	COG2119	membrane
I9190_00995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_00995	COG0426	domain, Protein
I9190_01015	COG0259	pyridoxamine-phosphate oxidase activity
I9190_01020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I9190_01065	COG2267	carboxylic ester hydrolase activity
I9190_01070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I9190_01085	COG2814	Major facilitator Superfamily
I9190_01095	COG0351	phosphomethylpyrimidine kinase
I9190_01095	COG0352	thiamine-phosphate diphosphorylase activity
I9190_01095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9190_01105	COG2814	Major facilitator Superfamily
I9190_01110	COG0629	single-stranded DNA binding
I9190_01115	COG0697	spore germination
I9190_01140	COG2271	Major facilitator Superfamily
I9190_01155	COG0583	DNA-binding transcription factor activity
I9190_01160	COG1335	isochorismatase
I9190_01170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I9190_01340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_01360	COG0582	viral genome integration into host DNA
I9190_01370	COG3158	transport of potassium into the cell
I9190_01390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I9190_01410	COG0165	Argininosuccinate lyase
I9190_01415	COG0745	RESPONSE REGULATOR receiver
I9190_01415	COG2972	Histidine kinase
I9190_01425	COG0181	hydroxymethylbilane synthase activity
I9190_01515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I9190_01530	COG0081	regulation of translation
I9190_01545	COG0085	RNA polymerase activity
I9190_01550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I9190_01580	COG2056	Na+-H+ antiporter family
I9190_01595	COG0326	Molecular chaperone. Has ATPase activity
I9190_01610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I9190_01685	COG0183	Belongs to the thiolase family
I9190_01690	COG1024	Enoyl-CoA hydratase
I9190_01690	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9190_01725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9190_01760	COG0795	lipopolysaccharide-transporting ATPase activity
I9190_01765	COG0795	lipopolysaccharide-transporting ATPase activity
I9190_01770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I9190_01775	COG0793	Belongs to the peptidase S41A family
I9190_01790	COG2197	response regulator
I9190_01795	COG1686	Belongs to the peptidase S11 family
I9190_01810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I9190_01825	COG4974	Belongs to the 'phage' integrase family
I9190_01845	COG1132	(ABC) transporter
I9190_01855	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_01865	COG1289	transmembrane transporter activity
I9190_01885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I9190_01895	COG0497	DNA recombination
I9190_01900	COG3123	guanosine phosphorylase activity
I9190_01905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9190_01915	COG0237	dephospho-CoA kinase activity
I9190_01965	COG0779	Required for maturation of 30S ribosomal subunits
I9190_01970	COG0195	Participates in both transcription termination and antitermination
I9190_01975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I9190_01980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I9190_01985	COG1704	LemA family
I9190_01990	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9190_02080	COG3307	-O-antigen
I9190_02095	COG3307	-O-antigen
I9190_02115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9190_02120	COG1758	RNA polymerase activity
I9190_02125	COG0194	GDP metabolic process
I9190_02135	COG4969	Belongs to the N-Me-Phe pilin family
I9190_02170	COG4969	Belongs to the N-Me-Phe pilin family
I9190_02205	COG0228	four-way junction DNA binding
I9190_02210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I9190_02220	COG0335	large ribosomal subunit rRNA binding
I9190_02230	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9190_02245	COG5380	lipid catabolic process
I9190_02250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I9190_02275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9190_02285	COG5006	permease, DMT superfamily
I9190_02290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I9190_02295	COG0277	FAD linked oxidase domain protein
I9190_02335	COG2814	Major facilitator Superfamily
I9190_02345	COG1289	transmembrane transporter activity
I9190_02360	COG2032	superoxide dismutase activity
I9190_02365	COG0628	permease
I9190_02380	COG2226	methyltransferase
I9190_02425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I9190_02450	COG0752	glycyl-tRNA synthetase alpha subunit
I9190_02460	COG0277	FAD linked oxidase domain protein
I9190_02475	COG0517	IMP dehydrogenase activity
I9190_02480	COG1983	PspC domain protein
I9190_02510	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_02515	COG1530	ribonuclease E activity
I9190_02525	COG0546	phosphoglycolate phosphatase activity
I9190_02530	COG2378	regulation of single-species biofilm formation
I9190_02545	COG0583	DNA-binding transcription factor activity
I9190_02585	COG0753	catalase activity
I9190_02595	COG1960	acyl-CoA dehydrogenase activity
I9190_02620	COG0494	nUDIX hydrolase
I9190_02635	COG0583	DNA-binding transcription factor activity
I9190_02650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I9190_02665	COG0473	3-isopropylmalate dehydrogenase activity
I9190_02675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I9190_02690	COG0252	asparaginase activity
I9190_02725	COG1560	Kdo2-lipid A biosynthetic process
I9190_02765	COG0488	(ABC) transporter
I9190_02770	COG2900	Belongs to the SlyX family
I9190_02775	COG0583	DNA-binding transcription factor activity
I9190_02780	COG1914	H( )-stimulated, divalent metal cation uptake system
I9190_02800	COG4770	biotin carboxylase activity
I9190_02810	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_02815	COG1733	regulation of RNA biosynthetic process
I9190_02845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_02850	COG1929	Belongs to the glycerate kinase type-1 family
I9190_02875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I9190_02875	COG4651	solute:proton antiporter activity
I9190_02900	COG0788	formyltetrahydrofolate deformylase activity
I9190_02945	COG1607	acyl-coa hydrolase
I9190_02960	COG1666	GTP binding
I9190_02965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I9190_02980	COG2350	Protein conserved in bacteria
I9190_02990	COG0613	PHP domain protein
I9190_03000	COG1702	phosphate starvation-inducible protein PhoH
I9190_03005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I9190_03010	COG1196	nuclear chromosome segregation
I9190_03010	COG0739	heme binding
I9190_03010	COG0741	lytic transglycosylase activity
I9190_03020	COG0039	L-malate dehydrogenase activity
I9190_03040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I9190_03045	COG1183	phosphatidylcholine synthase activity
I9190_03085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9190_03090	COG1960	acyl-CoA dehydrogenase activity
I9190_03095	COG1960	acyl-CoA dehydrogenase activity
I9190_03115	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_03120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I9190_03125	COG1960	acyl-CoA dehydrogenase activity
I9190_03130	COG1024	Enoyl-CoA hydratase
I9190_03135	COG4770	biotin carboxylase activity
I9190_03140	COG0564	pseudouridine synthase activity
I9190_03145	COG0477	Major facilitator Superfamily
I9190_03150	COG1272	protein, Hemolysin III
I9190_03170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9190_03175	COG1011	Hydrolase
I9190_03270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9190_03295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I9190_03300	COG3545	Serine hydrolase
I9190_03320	COG0730	response to heat
I9190_03330	COG1196	nuclear chromosome segregation
I9190_03340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I9190_03355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I9190_03365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9190_03375	COG2267	carboxylic ester hydrolase activity
I9190_03390	COG4106	trans-aconitate 2-methyltransferase activity
I9190_03405	COG3422	double-strand break repair
I9190_03420	COG1051	belongs to the nudix hydrolase family
I9190_03435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I9190_03440	COG2207	Transcriptional regulator
I9190_03445	COG0454	-acetyltransferase
I9190_03450	COG0456	acetyltransferase
I9190_03460	COG0183	Belongs to the thiolase family
I9190_03500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I9190_03505	COG0285	dihydrofolate synthase activity
I9190_03525	COG3713	MltA-interacting MipA family protein
I9190_03530	COG0009	L-threonylcarbamoyladenylate synthase
I9190_03535	COG3101	peptidyl-lysine hydroxylation
I9190_03540	COG1399	metal-binding, possibly nucleic acid-binding protein
I9190_03555	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_03560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9190_03565	COG1652	LysM domain
I9190_03570	COG0450	alkyl hydroperoxide reductase
I9190_03585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I9190_03590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I9190_03620	COG2199	diguanylate cyclase activity
I9190_03680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I9190_03685	COG3878	Protein conserved in bacteria
I9190_03720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9190_03735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I9190_03760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9190_03760	COG2813	Specifically methylates the guanine in position
I9190_03770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I9190_03780	COG3128	pkhd-type hydroxylase
I9190_03785	COG4774	siderophore transport
I9190_03790	COG4774	siderophore transport
I9190_03800	COG0740	serine-type endopeptidase activity
I9190_03845	COG0280	phosphate acetyltransferase
I9190_03845	COG0857	belongs to the CobB CobQ family
I9190_03850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I9190_03895	COG2832	Protein of unknown function (DUF454)
I9190_03950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I9190_03960	COG1289	transmembrane transporter activity
I9190_03965	COG2814	Major facilitator Superfamily
I9190_03980	COG0668	transmembrane transport
I9190_03995	COG2081	HI0933 family
I9190_04000	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I9190_04015	COG1309	transcriptional regulator
I9190_04030	COG2226	methyltransferase
I9190_04050	COG4716	Myosin-crossreactive antigen
I9190_04075	COG1126	abc transporter atp-binding protein
I9190_04080	COG0765	amino acid transport
I9190_04085	COG0765	amino acid transport
I9190_04090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9190_04115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I9190_04125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I9190_04180	COG0494	nUDIX hydrolase
I9190_04185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9190_04190	COG1214	PFAM Peptidase M22, glycoprotease
I9190_04195	COG1968	undecaprenyl-diphosphatase activity
I9190_04210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I9190_04215	COG4269	membrane
I9190_04225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I9190_04235	COG2132	Multicopper oxidase
I9190_04260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I9190_04265	COG1280	lysine exporter protein (LysE YggA)
I9190_04280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9190_04280	COG0352	thiamine-phosphate diphosphorylase activity
I9190_04280	COG0351	phosphomethylpyrimidine kinase
I9190_04305	COG0251	oxidation-reduction process
I9190_04310	COG1113	amino acid transport
I9190_04345	COG1981	membrane
I9190_04355	COG3831	ATPase activity
I9190_04365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I9190_04375	COG0714	Associated with various cellular activities
I9190_04385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I9190_04410	COG0456	acetyltransferase
I9190_04420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I9190_04425	COG0500	methyltransferase
I9190_04430	COG0492	ferredoxin-NADP+ reductase activity
I9190_04435	COG0531	amino acid
I9190_04435	COG1674	ftsk spoiiie
I9190_04445	COG1280	lysine exporter protein (LysE YggA)
I9190_04475	COG0523	cobalamin synthesis protein
I9190_04480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9190_04535	COG0183	Belongs to the thiolase family
I9190_04560	COG1690	Belongs to the RtcB family
I9190_04565	COG0833	amino acid
I9190_04575	COG2233	PERMEase
I9190_04580	COG1217	gtp-binding protein TYPA
I9190_04585	COG1970	mechanosensitive ion channel activity
I9190_04600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9190_04610	COG3659	wide pore channel activity
I9190_04615	COG4772	TonB-dependent receptor
I9190_04620	COG1902	pentaerythritol trinitrate reductase activity
I9190_04670	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9190_04690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I9190_04730	COG5001	Diguanylate cyclase
I9190_04730	COG3447	MASE1 domain protein
I9190_04730	COG5002	protein histidine kinase activity
I9190_04755	COG2969	positive regulation of protein catabolic process
I9190_04760	COG0625	glutathione transferase activity
I9190_04770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I9190_04775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I9190_04790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I9190_04795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9190_04835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I9190_04845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9190_04850	COG1408	metallophosphoesterase
I9190_04880	COG2824	Alkylphosphonate utilization operon protein PhnA
I9190_04885	COG0590	tRNA wobble adenosine to inosine editing
I9190_04915	COG4166	transmembrane transport
I9190_04920	COG4166	transmembrane transport
I9190_04930	COG0601	transmembrane transport
I9190_04935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I9190_04950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I9190_04955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I9190_04975	COG1309	transcriptional regulator
I9190_04980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9190_04990	COG2268	Band 7 protein
I9190_04995	COG1585	Membrane protein implicated in regulation of membrane protease activity
I9190_05010	COG3706	GGDEF domain
I9190_05015	COG0477	Major facilitator Superfamily
I9190_05020	COG0242	peptide deformylase activity
I9190_05025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I9190_05035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9190_05045	COG2271	Major facilitator Superfamily
I9190_05065	COG0477	Major facilitator Superfamily
I9190_05070	COG2030	dehydratase
I9190_05070	COG1012	belongs to the aldehyde dehydrogenase family
I9190_05075	COG3396	Phenylacetate-CoA oxygenase
I9190_05080	COG3460	Phenylacetate-CoA oxygenase
I9190_05085	COG3396	Phenylacetate-CoA oxygenase
I9190_05090	COG2151	metal-sulfur cluster biosynthetic enzyme
I9190_05095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I9190_05100	COG1024	Enoyl-CoA hydratase
I9190_05105	COG1024	Enoyl-CoA hydratase
I9190_05110	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9190_05115	COG0183	Belongs to the thiolase family
I9190_05120	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I9190_05125	COG3327	negative regulation of DNA-templated transcription, initiation
I9190_05145	COG2985	domain, Protein
I9190_05160	COG1414	Transcriptional regulator
I9190_05165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_05210	COG1733	regulation of RNA biosynthetic process
I9190_05230	COG2771	luxR family
I9190_05235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_05250	COG0789	Transcriptional regulator
I9190_05265	COG2375	cellular response to nickel ion
I9190_05265	COG1132	(ABC) transporter
I9190_05275	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I9190_05280	COG4605	iron ion homeostasis
I9190_05285	COG4604	ABC transporter, ATP-binding protein
I9190_05290	COG4607	ABC-type enterochelin transport system periplasmic component
I9190_05295	COG4774	siderophore transport
I9190_05315	COG2267	carboxylic ester hydrolase activity
I9190_05320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_05325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_05330	COG1012	belongs to the aldehyde dehydrogenase family
I9190_05335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9190_05345	COG1012	belongs to the aldehyde dehydrogenase family
I9190_05350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_05370	COG3706	GGDEF domain
I9190_05375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_05380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I9190_05390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9190_05395	COG0505	Belongs to the CarA family
I9190_05410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I9190_05430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_05435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_05440	COG0745	RESPONSE REGULATOR receiver
I9190_05450	COG5002	protein histidine kinase activity
I9190_05460	COG3135	benzoate transporter
I9190_05465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9190_05475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9190_05480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I9190_05485	COG0022	dehydrogenase e1 component
I9190_05490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I9190_05495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_05505	COG1063	alcohol dehydrogenase
I9190_05525	COG0583	DNA-binding transcription factor activity
I9190_05530	COG0473	3-isopropylmalate dehydrogenase activity
I9190_05540	COG0657	acetylesterase activity
I9190_05545	COG4638	Rieske (2fe-2S)
I9190_05550	COG1012	belongs to the aldehyde dehydrogenase family
I9190_05570	COG3539	Fimbrial protein
I9190_05585	COG3121	Chaperone
I9190_05595	COG3539	Fimbrial protein
I9190_05615	COG3539	Fimbrial protein
I9190_05635	COG3121	Chaperone
I9190_05645	COG3539	Fimbrial protein
I9190_05660	COG0523	cobalamin synthesis protein
I9190_05670	COG1902	pentaerythritol trinitrate reductase activity
I9190_05670	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9190_05680	COG0789	Transcriptional regulator
I9190_05695	COG2871	sodium ion transport
I9190_05730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9190_05735	COG0183	Belongs to the thiolase family
I9190_05740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_05745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9190_05755	COG4829	muconolactone delta-isomerase
I9190_05760	COG4948	Mandelate Racemase Muconate Lactonizing
I9190_05765	COG0583	DNA-binding transcription factor activity
I9190_05795	COG0583	DNA-binding transcription factor activity
I9190_05800	COG3590	peptidase
I9190_05815	COG2318	DinB family
I9190_05835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9190_05845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9190_05850	COG1077	Cell shape determining protein MreB Mrl
I9190_05855	COG1792	Involved in formation and maintenance of cell shape
I9190_05860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I9190_05865	COG0424	maF-like protein
I9190_05880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I9190_05895	COG0560	Phosphoserine phosphatase
I9190_05920	COG4181	ATPase activity
I9190_05925	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I9190_05935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9190_05950	COG0583	DNA-binding transcription factor activity
I9190_05960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_05965	COG1773	rubredoxin
I9190_05970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I9190_06000	COG2354	Protein conserved in bacteria
I9190_06005	COG2321	neutral zinc metallopeptidase
I9190_06030	COG1024	Enoyl-CoA hydratase
I9190_06050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_06065	COG0625	glutathione transferase activity
I9190_06075	COG1113	amino acid transport
I9190_06085	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I9190_06095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I9190_06100	COG0505	Belongs to the CarA family
I9190_06120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I9190_06125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9190_06130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I9190_06150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I9190_06150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9190_06175	COG0300	oxidoreductase activity
I9190_06180	COG2072	flavoprotein involved in K transport
I9190_06215	COG2009	succinate dehydrogenase
I9190_06220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I9190_06225	COG1053	succinate dehydrogenase
I9190_06230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I9190_06245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_06255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I9190_06260	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_06280	COG0742	ribosomal rna small subunit methyltransferase
I9190_06285	COG0768	penicillin binding
I9190_06315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I9190_06320	COG2878	Part of a membrane complex involved in electron transport
I9190_06325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9190_06340	COG3384	dioxygenase
I9190_06350	COG2234	aminopeptidase activity
I9190_06395	COG1280	lysine exporter protein (LysE YggA)
I9190_06440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9190_06440	COG3323	Protein of unknown function (DUF1653)
I9190_06445	COG0778	Nitroreductase
I9190_06450	COG1024	Enoyl-CoA hydratase
I9190_06455	COG1056	cytidyltransferase-related domain
I9190_06455	COG1051	belongs to the nudix hydrolase family
I9190_06470	COG0625	glutathione transferase activity
I9190_06480	COG0583	DNA-binding transcription factor activity
I9190_06490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9190_06505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I9190_06510	COG0602	queuosine metabolic process
I9190_06530	COG0583	DNA-binding transcription factor activity
I9190_06535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I9190_06540	COG4208	sulfate ABC transporter
I9190_06545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I9190_06555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I9190_06560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I9190_06565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I9190_06605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9190_06615	COG0671	phosphoesterase, PA-phosphatase related
I9190_06620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I9190_06625	COG0463	Glycosyl transferase, family 2
I9190_06650	COG0571	ribonuclease III activity
I9190_06655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I9190_06670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I9190_06680	COG0667	Aldo Keto reductase
I9190_06690	COG0251	oxidation-reduction process
I9190_06695	COG0583	DNA-binding transcription factor activity
I9190_06710	COG0415	Belongs to the DNA photolyase family
I9190_06715	COG1047	Peptidyl-prolyl cis-trans
I9190_06720	COG1252	NADH dehydrogenase
I9190_06725	COG1686	Belongs to the peptidase S11 family
I9190_06735	COG2351	hydroxyisourate hydrolase activity
I9190_06750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9190_06755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_06760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I9190_06795	COG0280	phosphate acetyltransferase
I9190_06795	COG0281	malic enzyme
I9190_06805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9190_06810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I9190_06815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I9190_06835	COG0154	amidase activity
I9190_06870	COG1960	acyl-CoA dehydrogenase activity
I9190_06920	COG0583	DNA-binding transcription factor activity
I9190_06925	COG0697	spore germination
I9190_06935	COG2186	Transcriptional regulator
I9190_06945	COG0277	FAD linked oxidase domain protein
I9190_06955	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9190_06955	COG1902	pentaerythritol trinitrate reductase activity
I9190_06965	COG0582	viral genome integration into host DNA
I9190_06985	COG2831	hemolysin activation secretion protein
I9190_07025	COG1012	belongs to the aldehyde dehydrogenase family
I9190_07050	COG2072	flavoprotein involved in K transport
I9190_07140	COG1012	belongs to the aldehyde dehydrogenase family
I9190_07145	COG0531	amino acid
I9190_07150	COG2957	Belongs to the agmatine deiminase family
I9190_07155	COG1116	anion transmembrane transporter activity
I9190_07155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_07165	COG2223	nitrite transmembrane transporter activity
I9190_07170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_07170	COG2146	nitrite reductase [NAD(P)H] activity
I9190_07175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_07180	COG0243	molybdopterin cofactor binding
I9190_07190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I9190_07200	COG0314	molybdopterin synthase activity
I9190_07205	COG0521	Mo-molybdopterin cofactor biosynthetic process
I9190_07205	COG0315	cyclic pyranopterin monophosphate synthase activity
I9190_07210	COG0303	'Molybdopterin
I9190_07215	COG0725	ABC transporter, periplasmic molybdate-binding protein
I9190_07220	COG4149	molybdate abc transporter
I9190_07225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I9190_07230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_07240	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I9190_07245	COG0583	DNA-binding transcription factor activity
I9190_07265	COG0439	Biotin carboxylase
I9190_07270	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_07275	COG1733	regulation of RNA biosynthetic process
I9190_07280	COG0864	Transcriptional regulator
I9190_07310	COG1116	anion transmembrane transporter activity
I9190_07330	COG0596	Alpha beta hydrolase
I9190_07340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_07345	COG1335	isochorismatase
I9190_07350	COG0251	oxidation-reduction process
I9190_07355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_07360	COG2233	PERMEase
I9190_07375	COG0235	Class ii aldolase
I9190_07380	COG1741	Belongs to the pirin family
I9190_07395	COG3739	integral membrane protein
I9190_07415	COG0531	amino acid
I9190_07420	COG4303	Ethanolamine ammonia lyase large subunit
I9190_07425	COG4302	ethanolamine ammonia-lyase activity
I9190_07430	COG1960	acyl-CoA dehydrogenase activity
I9190_07435	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_07465	COG0302	gtp cyclohydrolase
I9190_07485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9190_07490	COG0512	Glutamine amidotransferase of anthranilate synthase
I9190_07545	COG0174	glutamine synthetase
I9190_07565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9190_07590	COG0823	Involved in the tonB-independent uptake of proteins
I9190_07620	COG0824	Thioesterase
I9190_07650	COG4771	TonB-dependent receptor
I9190_07685	COG0047	phosphoribosylformylglycinamidine synthase activity
I9190_07685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I9190_07700	COG1301	dicarboxylic acid transport
I9190_07715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_07740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I9190_07790	COG1960	acyl-CoA dehydrogenase activity
I9190_07795	COG0183	Belongs to the thiolase family
I9190_07800	COG0427	acetyl-CoA hydrolase
I9190_07810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9190_07810	COG0517	IMP dehydrogenase activity
I9190_07815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I9190_07825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I9190_07830	COG1137	ATPase activity
I9190_07855	COG4122	O-methyltransferase activity
I9190_07870	COG0573	inorganic phosphate transmembrane transporter activity
I9190_07880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I9190_07885	COG1301	dicarboxylic acid transport
I9190_07890	COG0616	signal peptide processing
I9190_07895	COG1960	acyl-CoA dehydrogenase activity
I9190_07905	COG0693	protein deglycase activity
I9190_07915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I9190_07935	COG0430	RNA-3'-phosphate cyclase activity
I9190_07960	COG1690	Belongs to the RtcB family
I9190_07975	COG1234	tRNA 3'-trailer cleavage
I9190_07980	COG4650	regulator
I9190_07990	COG3022	response to hydroperoxide
I9190_08085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9190_08095	COG2011	ABC-type metal ion transport system permease component
I9190_08100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9190_08105	COG1464	Belongs to the NlpA lipoprotein family
I9190_08115	COG0151	Belongs to the GarS family
I9190_08120	COG0138	bifunctional purine biosynthesis protein purh
I9190_08125	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I9190_08165	COG2308	Evidence 4 Homologs of previously reported genes of
I9190_08175	COG1305	Transglutaminase-like
I9190_08195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I9190_08205	COG0305	Participates in initiation and elongation during chromosome replication
I9190_08215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I9190_08220	COG0360	Binds together with S18 to 16S ribosomal RNA
I9190_08240	COG0109	protoheme IX farnesyltransferase activity
I9190_08245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I9190_08250	COG1845	cytochrome c oxidase, subunit III
I9190_08255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I9190_08260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I9190_08290	COG4682	membrane
I9190_08295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_08315	COG2890	protein-(glutamine-N5) methyltransferase activity
I9190_08320	COG3781	membrane
I9190_08325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9190_08330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_08350	COG1960	acyl-CoA dehydrogenase activity
I9190_08355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9190_08365	COG4585	Histidine kinase
I9190_08375	COG0659	secondary active sulfate transmembrane transporter activity
I9190_08385	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_08390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I9190_08420	COG2363	Small membrane protein
I9190_08440	COG0513	Belongs to the DEAD box helicase family
I9190_08450	COG0778	Nitroreductase
I9190_08475	COG0167	dihydroorotate dehydrogenase activity
I9190_08505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I9190_08505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I9190_08510	COG1254	Belongs to the acylphosphatase family
I9190_08540	COG1280	lysine exporter protein (LysE YggA)
I9190_08575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I9190_08590	COG2353	YceI-like domain
I9190_08600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9190_08610	COG3042	response to heat
I9190_08615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9190_08615	COG0519	Catalyzes the synthesis of GMP from XMP
I9190_08620	COG1309	transcriptional regulator
I9190_08640	COG0583	DNA-binding transcription factor activity
I9190_08660	COG3284	Transcriptional regulator
I9190_08675	COG1454	alcohol dehydrogenase
I9190_08685	COG0183	Belongs to the thiolase family
I9190_08730	COG0824	Thioesterase
I9190_08740	COG1454	alcohol dehydrogenase
I9190_08805	COG0537	adenosine 5'-monophosphoramidase activity
I9190_08835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I9190_08855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9190_08865	COG0133	tryptophan synthase activity
I9190_08875	COG0517	IMP dehydrogenase activity
I9190_08875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9190_08905	COG0612	Peptidase, M16
I9190_08910	COG0552	protein localization to endoplasmic reticulum
I9190_08920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I9190_08940	COG1253	flavin adenine dinucleotide binding
I9190_08960	COG1114	Component of the transport system for branched-chain amino acids
I9190_08965	COG0024	Methionine aminopeptidase
I9190_08970	COG3135	benzoate transporter
I9190_08980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I9190_09000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_09005	COG2119	membrane
I9190_09010	COG2194	sulfuric ester hydrolase activity
I9190_09065	COG4890	Cyd operon protein YbgT
I9190_09070	COG1294	oxidase, subunit
I9190_09085	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I9190_09105	COG2153	protein acetylation
I9190_09120	COG1846	Transcriptional regulator
I9190_09125	COG1132	(ABC) transporter
I9190_09130	COG1304	FMN binding
I9190_09145	COG4773	Receptor
I9190_09150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9190_09165	COG3753	Protein conserved in bacteria
I9190_09180	COG3852	Histidine kinase
I9190_09195	COG0233	cytoplasmic translational termination
I9190_09200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I9190_09205	COG0575	Belongs to the CDS family
I9190_09220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9190_09230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9190_09240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9190_09260	COG2137	regulation of response to DNA damage stimulus
I9190_09265	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_09270	COG4221	oxidoreductase activity
I9190_09275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I9190_09280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I9190_09285	COG1011	Hydrolase
I9190_09315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I9190_09320	COG0730	response to heat
I9190_09340	COG0439	Biotin carboxylase
I9190_09345	COG0511	ligase activity, forming carbon-carbon bonds
I9190_09385	COG1846	Transcriptional regulator
I9190_09395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I9190_09410	COG0308	aminopeptidase N
I9190_09445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I9190_09445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I9190_09445	COG0506	proline dehydrogenase activity
I9190_09455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9190_09470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I9190_09490	COG0477	Major facilitator Superfamily
I9190_09500	COG3179	chitinase
I9190_09520	COG3135	benzoate transporter
I9190_09525	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_09530	COG0633	Ferredoxin
I9190_09530	COG0543	2 iron, 2 sulfur cluster binding
I9190_09535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I9190_09540	COG4638	Rieske (2fe-2S)
I9190_09550	COG0583	DNA-binding transcription factor activity
I9190_09555	COG2814	Major facilitator Superfamily
I9190_09575	COG1902	pentaerythritol trinitrate reductase activity
I9190_09575	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9190_09600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I9190_09610	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I9190_09620	COG0772	Belongs to the SEDS family
I9190_09625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9190_09675	COG0583	DNA-binding transcription factor activity
I9190_09680	COG0667	Aldo Keto reductase
I9190_09710	COG1309	transcriptional regulator
I9190_09715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9190_09715	COG0596	Alpha beta hydrolase
I9190_09715	COG2226	methyltransferase
I9190_09720	COG2937	Belongs to the GPAT DAPAT family
I9190_09725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I9190_09785	COG4589	Belongs to the CDS family
I9190_09800	COG0671	phosphoesterase, PA-phosphatase related
I9190_09800	COG2453	phosphatase
I9190_09805	COG2267	carboxylic ester hydrolase activity
I9190_09810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9190_09860	COG2223	nitrite transmembrane transporter activity
I9190_09880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I9190_09895	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I9190_09915	COG0640	Transcriptional regulator
I9190_09925	COG3122	Protein conserved in bacteria
I9190_09930	COG3619	membrane
I9190_09945	COG0640	Transcriptional regulator
I9190_09975	COG5001	Diguanylate cyclase
I9190_09975	COG3300	MHYT domain
I9190_09980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I9190_09985	COG0509	glycine decarboxylation via glycine cleavage system
I9190_10005	COG1960	acyl-CoA dehydrogenase activity
I9190_10010	COG1960	acyl-CoA dehydrogenase activity
I9190_10060	COG0589	response to stress
I9190_10070	COG0830	nickel cation binding
I9190_10085	COG0829	nickel cation binding
I9190_10105	COG0804	urea catabolic process
I9190_10140	COG2351	hydroxyisourate hydrolase activity
I9190_10150	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I9190_10155	COG4266	Belongs to the allantoicase family
I9190_10160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_10165	COG0583	DNA-binding transcription factor activity
I9190_10180	COG1944	ATP diphosphatase activity
I9190_10200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9190_10205	COG1960	acyl-CoA dehydrogenase activity
I9190_10210	COG1024	Enoyl-CoA hydratase
I9190_10220	COG0477	Major facilitator Superfamily
I9190_10235	COG1881	PFAM PEBP family protein
I9190_10240	COG2207	Transcriptional regulator
I9190_10250	COG4774	siderophore transport
I9190_10260	COG2814	Major facilitator Superfamily
I9190_10390	COG0583	DNA-binding transcription factor activity
I9190_10395	COG1380	Effector of murein hydrolase LrgA
I9190_10400	COG1346	cytolysis
I9190_10405	COG2814	Major facilitator Superfamily
I9190_10420	COG0697	spore germination
I9190_10425	COG0596	Alpha beta hydrolase
I9190_10430	COG1448	Aminotransferase
I9190_10435	COG0488	(ABC) transporter
I9190_10470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I9190_10475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9190_10485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9190_10490	COG0697	spore germination
I9190_10545	COG0583	DNA-binding transcription factor activity
I9190_10550	COG3152	Membrane
I9190_10560	COG1294	oxidase, subunit
I9190_10565	COG1271	oxidase subunit
I9190_10575	COG2207	Transcriptional regulator
I9190_10580	COG1960	acyl-CoA dehydrogenase activity
I9190_10600	COG1733	regulation of RNA biosynthetic process
I9190_10630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9190_10640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I9190_10775	COG4387	Mu-like prophage protein GP36
I9190_10920	COG2203	Gaf domain
I9190_10920	COG2199	diguanylate cyclase activity
I9190_10970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I9190_11000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_11005	COG2207	Transcriptional regulator
I9190_11015	COG0776	regulation of translation
I9190_11030	COG1959	2 iron, 2 sulfur cluster binding
I9190_11040	COG0822	iron-sulfur transferase activity
I9190_11045	COG0316	Belongs to the HesB IscA family
I9190_11075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I9190_11105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I9190_11110	COG0702	epimerase
I9190_11120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I9190_11145	COG3196	Protein conserved in bacteria
I9190_11170	COG0126	phosphoglycerate kinase activity
I9190_11180	COG0424	maF-like protein
I9190_11185	COG2850	peptidyl-arginine hydroxylation
I9190_11195	COG0069	glutamate synthase activity
I9190_11215	COG3433	isochorismatase activity
I9190_11215	COG1535	isochorismatase
I9190_11220	COG0372	Belongs to the citrate synthase family
I9190_11260	COG2814	Major facilitator Superfamily
I9190_11265	COG1960	acyl-CoA dehydrogenase activity
I9190_11270	COG0583	DNA-binding transcription factor activity
I9190_11280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9190_11285	COG0583	DNA-binding transcription factor activity
I9190_11310	COG2755	lipolytic protein G-D-S-L family
I9190_11310	COG0657	acetylesterase activity
I9190_11315	COG0542	response to heat
I9190_11320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I9190_11335	COG3706	GGDEF domain
I9190_11370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I9190_11375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9190_11390	COG0569	domain protein
I9190_11395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I9190_11400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I9190_11415	COG2431	L-lysine efflux transmembrane transporter activity
I9190_11420	COG0284	orotidine-5'-phosphate decarboxylase activity
I9190_11455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I9190_11465	COG0590	tRNA wobble adenosine to inosine editing
I9190_11475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I9190_11485	COG3156	type II secretion system protein K
I9190_11510	COG0084	hydrolase, TatD family'
I9190_11530	COG1663	tetraacyldisaccharide 4'-kinase activity
I9190_11535	COG1132	(ABC) transporter
I9190_11545	COG0811	peptide transport
I9190_11550	COG1475	DNA binding
I9190_11555	COG1192	Involved in chromosome partitioning
I9190_11565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I9190_11570	COG3178	'Phosphotransferase
I9190_11580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9190_11615	COG1923	regulation of RNA biosynthetic process
I9190_11625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I9190_11630	COG0802	atpase or kinase
I9190_11650	COG1187	pseudouridine synthase activity
I9190_11655	COG0492	ferredoxin-NADP+ reductase activity
I9190_11660	COG1959	2 iron, 2 sulfur cluster binding
I9190_11665	COG2707	UPF0756 membrane protein
I9190_11690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9190_11800	COG4397	Mu-like prophage major head subunit gpT
I9190_11815	COG5005	Phage virion morphogenesis
I9190_11825	COG4383	Mu-like prophage protein gp29
I9190_11840	COG4373	Mu-like prophage FluMu protein gp28
I9190_11875	COG0681	Belongs to the peptidase S26 family
I9190_11955	COG4382	Mu-like prophage protein Gp16
I9190_12020	COG1464	Belongs to the NlpA lipoprotein family
I9190_12025	COG1464	Belongs to the NlpA lipoprotein family
I9190_12030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9190_12035	COG2011	ABC-type metal ion transport system permease component
I9190_12040	COG0012	GTP binding
I9190_12065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9190_12090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I9190_12110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I9190_12160	COG2207	Transcriptional regulator
I9190_12160	COG1917	Cupin 2, conserved barrel domain protein
I9190_12165	COG0386	Belongs to the glutathione peroxidase family
I9190_12170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_12175	COG0436	Aminotransferase
I9190_12205	COG1610	YqeY-like protein
I9190_12215	COG4783	chaperone-mediated protein folding
I9190_12235	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_12255	COG0729	surface antigen
I9190_12260	COG0477	Major facilitator Superfamily
I9190_12280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I9190_12290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I9190_12305	COG0204	Acyl-transferase
I9190_12320	COG1309	transcriptional regulator
I9190_12370	COG3340	Belongs to the peptidase S51 family
I9190_12390	COG0583	DNA-binding transcription factor activity
I9190_12395	COG3040	lipid binding
I9190_12400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I9190_12410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9190_12435	COG0540	Belongs to the ATCase OTCase family
I9190_12510	COG0542	response to heat
I9190_12520	COG1045	serine acetyltransferase
I9190_12530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9190_12535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I9190_12545	COG1765	OsmC-like protein
I9190_12555	COG0667	Aldo Keto reductase
I9190_12575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I9190_12590	COG1335	isochorismatase
I9190_12595	COG1522	sequence-specific DNA binding
I9190_12600	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I9190_12605	COG1522	sequence-specific DNA binding
I9190_12625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I9190_12645	COG0527	aspartate kinase activity
I9190_12655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I9190_12740	COG3038	cytochrome b561
I9190_12750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I9190_12755	COG2252	PERMEase
I9190_12770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_12805	COG4771	TonB-dependent receptor
I9190_12825	COG0714	Associated with various cellular activities
I9190_12835	COG2879	small protein
I9190_12840	COG1966	Carbon starvation protein
I9190_12845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I9190_12850	COG1509	lysine 2,3-aminomutase activity
I9190_12885	COG1067	ATP-dependent peptidase activity
I9190_12890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I9190_12895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9190_12905	COG4942	peptidase
I9190_12910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I9190_12925	COG1686	Belongs to the peptidase S11 family
I9190_12930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9190_12965	COG2915	High frequency lysogenization protein hflD homolog
I9190_12980	COG1733	regulation of RNA biosynthetic process
I9190_12985	COG0702	epimerase
I9190_13020	COG2962	Rard protein
I9190_13030	COG0556	nucleotide-excision repair
I9190_13040	COG3300	MHYT domain
I9190_13040	COG5001	Diguanylate cyclase
I9190_13055	COG0436	Aminotransferase
I9190_13075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_13085	COG2223	nitrite transmembrane transporter activity
I9190_13095	COG0477	Major facilitator Superfamily
I9190_13130	COG0028	Belongs to the TPP enzyme family
I9190_13145	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_13150	COG2267	carboxylic ester hydrolase activity
I9190_13160	COG2271	Major facilitator Superfamily
I9190_13235	COG0583	DNA-binding transcription factor activity
I9190_13280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_13290	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_13315	COG0154	amidase activity
I9190_13325	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9190_13335	COG3708	Transcriptional regulator
I9190_13335	COG2207	Transcriptional regulator
I9190_13340	COG2814	Major facilitator Superfamily
I9190_13350	COG2610	gluconate transmembrane transporter activity
I9190_13355	COG1454	alcohol dehydrogenase
I9190_13380	COG2271	Major facilitator Superfamily
I9190_13385	COG0697	spore germination
I9190_13395	COG1012	belongs to the aldehyde dehydrogenase family
I9190_13400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I9190_13405	COG2271	Major facilitator Superfamily
I9190_13415	COG2186	Transcriptional regulator
I9190_13420	COG1785	Belongs to the alkaline phosphatase family
I9190_13440	COG3321	synthase
I9190_13440	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_13440	COG0604	alcohol dehydrogenase
I9190_13445	COG1309	transcriptional regulator
I9190_13450	COG0477	Major facilitator Superfamily
I9190_13465	COG2814	Major facilitator Superfamily
I9190_13470	COG1309	transcriptional regulator
I9190_13480	COG5487	UPF0391 membrane protein
I9190_13500	COG0693	protein deglycase activity
I9190_13530	COG3008	intermembrane lipid transfer
I9190_13530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9190_13535	COG2995	paraquat-inducible protein a
I9190_13560	COG0745	RESPONSE REGULATOR receiver
I9190_13565	COG0642	Histidine kinase
I9190_13580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I9190_13615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I9190_13625	COG0076	glutamate decarboxylase activity
I9190_13630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I9190_13640	COG4772	TonB-dependent receptor
I9190_13670	COG1309	transcriptional regulator
I9190_13685	COG1022	Amp-dependent synthetase and ligase
I9190_13730	COG0789	Transcriptional regulator
I9190_13735	COG0798	PFAM Bile acid sodium symporter
I9190_13740	COG0640	Transcriptional regulator
I9190_13750	COG0826	peptidase U32
I9190_13755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9190_13760	COG0583	DNA-binding transcription factor activity
I9190_13765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I9190_13770	COG3634	alkyl hydroperoxide reductase activity
I9190_13810	COG0628	permease
I9190_13820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I9190_13840	COG2333	competence protein COMEC
I9190_13840	COG0658	competence protein
I9190_13845	COG1136	(ABC) transporter
I9190_13870	COG2072	flavoprotein involved in K transport
I9190_13890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9190_13895	COG0010	Belongs to the arginase family
I9190_13905	COG1113	amino acid transport
I9190_13925	COG2188	Transcriptional regulator
I9190_13930	COG2831	hemolysin activation secretion protein
I9190_13935	COG3210	domain, Protein
I9190_13970	COG1643	Atp-dependent helicase
I9190_13995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I9190_14020	COG2070	2-Nitropropane dioxygenase
I9190_14025	COG2318	DinB family
I9190_14065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I9190_14075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I9190_14080	COG1301	dicarboxylic acid transport
I9190_14085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9190_14095	COG3139	Protein of unknown function (DUF1315)
I9190_14100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I9190_14105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9190_14115	COG0494	nUDIX hydrolase
I9190_14125	COG0642	Histidine kinase
I9190_14135	COG3111	PFAM Bacterial OB fold (BOF) protein
I9190_14140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I9190_14185	COG0352	thiamine-phosphate diphosphorylase activity
I9190_14200	COG3025	triphosphatase activity
I9190_14205	COG1720	tRNA m6t6A37 methyltransferase activity
I9190_14220	COG0612	Peptidase, M16
I9190_14240	COG1823	symporter activity
I9190_14245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_14255	COG2233	PERMEase
I9190_14265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I9190_14280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9190_14340	COG1131	(ABC) transporter
I9190_14345	COG0842	Transport permease protein
I9190_14360	COG0772	Belongs to the SEDS family
I9190_14365	COG2951	lytic endotransglycosylase activity
I9190_14415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I9190_14420	COG0052	Belongs to the universal ribosomal protein uS2 family
I9190_14425	COG0024	Methionine aminopeptidase
I9190_14445	COG4172	Belongs to the ABC transporter superfamily
I9190_14450	COG4239	(ABC) transporter, permease
I9190_14455	COG4174	ABC transporter (Permease)
I9190_14460	COG4166	transmembrane transport
I9190_14465	COG0741	lytic transglycosylase activity
I9190_14465	COG1388	LysM domain
I9190_14470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9190_14520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_14525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_14530	COG0006	proline dipeptidase activity
I9190_14570	COG1629	transport
I9190_14615	COG1595	DNA-templated transcription, initiation
I9190_14625	COG2832	Protein of unknown function (DUF454)
I9190_14640	COG0745	RESPONSE REGULATOR receiver
I9190_14645	COG2205	protein histidine kinase activity
I9190_14655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I9190_14660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I9190_14665	COG1968	undecaprenyl-diphosphatase activity
I9190_14670	COG1923	regulation of RNA biosynthetic process
I9190_14685	COG2205	protein histidine kinase activity
I9190_14690	COG2217	Heavy metal translocating P-type atpase
I9190_14710	COG0789	Transcriptional regulator
I9190_14725	COG0583	DNA-binding transcription factor activity
I9190_14735	COG0583	DNA-binding transcription factor activity
I9190_14750	COG3188	usher protein
I9190_14765	COG4993	Dehydrogenase
I9190_14770	COG3659	wide pore channel activity
I9190_14775	COG3420	alginic acid biosynthetic process
I9190_14780	COG0710	3-dehydroquinate dehydratase activity
I9190_14785	COG3485	protocatechuate 3,4-dioxygenase
I9190_14790	COG3485	protocatechuate 3,4-dioxygenase
I9190_14795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_14800	COG2271	Major facilitator Superfamily
I9190_14805	COG0596	Alpha beta hydrolase
I9190_14810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I9190_14815	COG0183	Belongs to the thiolase family
I9190_14820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_14825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9190_14830	COG1414	Transcriptional regulator
I9190_14900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_14920	COG3712	iron ion homeostasis
I9190_14925	COG1595	DNA-templated transcription, initiation
I9190_14940	COG0583	DNA-binding transcription factor activity
I9190_14960	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_14965	COG2610	gluconate transmembrane transporter activity
I9190_14970	COG0583	DNA-binding transcription factor activity
I9190_14980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_14985	COG0625	glutathione transferase activity
I9190_14990	COG0668	transmembrane transport
I9190_14995	COG0582	viral genome integration into host DNA
I9190_15030	COG1230	cation diffusion facilitator family transporter
I9190_15045	COG2814	Major facilitator Superfamily
I9190_15145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9190_15170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_15195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I9190_15240	COG0582	viral genome integration into host DNA
I9190_15250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9190_15255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I9190_15265	COG0037	tRNA processing
I9190_15270	COG0741	lytic transglycosylase activity
I9190_15275	COG0501	Belongs to the peptidase M48B family
I9190_15295	COG0418	dihydroorotase activity
I9190_15300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9190_15310	COG0833	amino acid
I9190_15320	COG0833	amino acid
I9190_15325	COG0596	Alpha beta hydrolase
I9190_15340	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I9190_15350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I9190_15370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I9190_15375	COG0019	diaminopimelate decarboxylase activity
I9190_15385	COG1113	amino acid transport
I9190_15405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9190_15410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9190_15415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9190_15445	COG2239	Acts as a magnesium transporter
I9190_15450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_15455	COG0584	glycerophosphoryl diester phosphodiesterase
I9190_15465	COG0459	protein refolding
I9190_15475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9190_15480	COG1597	lipid kinase activity
I9190_15485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I9190_15510	COG0477	Major facilitator Superfamily
I9190_15570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9190_15575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I9190_15580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I9190_15605	COG0564	pseudouridine synthase activity
I9190_15615	COG0358	DNA primase activity
I9190_15660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9190_15665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I9190_15670	COG0193	aminoacyl-tRNA hydrolase activity
I9190_15690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9190_15705	COG0586	Pfam SNARE associated Golgi protein
I9190_15710	COG1280	lysine exporter protein (LysE YggA)
I9190_15735	COG2921	Belongs to the UPF0250 family
I9190_15740	COG0321	lipoyl(octanoyl) transferase activity
I9190_15755	COG0531	amino acid
I9190_15780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I9190_15785	COG1648	precorrin-2 dehydrogenase activity
I9190_15785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I9190_15790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I9190_15800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I9190_15810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I9190_15825	COG0671	phosphoesterase, PA-phosphatase related
I9190_15830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_15845	COG0393	Putative heavy-metal-binding
I9190_15865	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_15875	COG0525	valine-tRNA ligase activity
I9190_15880	COG2852	Protein conserved in bacteria
I9190_15885	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_15905	COG0004	ammonium transporteR
I9190_15920	COG0642	Histidine kinase
I9190_15930	COG2194	sulfuric ester hydrolase activity
I9190_15945	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9190_15960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9190_15965	COG0142	geranyltranstransferase activity
I9190_15975	COG2828	Protein conserved in bacteria
I9190_15980	COG1113	amino acid transport
I9190_16015	COG4771	TonB-dependent receptor
I9190_16030	COG1024	Enoyl-CoA hydratase
I9190_16040	COG1309	transcriptional regulator
I9190_16075	COG1215	transferase activity, transferring glycosyl groups
I9190_16080	COG0726	polysaccharide deacetylase
I9190_16080	COG1649	PFAM Uncharacterised BCR, COG1649
I9190_16100	COG4681	YaeQ
I9190_16105	COG0523	cobalamin synthesis protein
I9190_16125	COG1607	acyl-coa hydrolase
I9190_16130	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9190_16135	COG2059	Chromate
I9190_16140	COG0786	glutamate:sodium symporter activity
I9190_16150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9190_16185	COG0420	3'-5' exonuclease activity
I9190_16210	COG1968	undecaprenyl-diphosphatase activity
I9190_16230	COG0735	belongs to the Fur family
I9190_16235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9190_16250	COG2703	oxygen carrier activity
I9190_16255	COG0121	glutamine amidotransferase
I9190_16270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9190_16275	COG0756	dUTP diphosphatase activity
I9190_16285	COG2885	chlorophyll binding
I9190_16290	COG0204	Acyl-transferase
I9190_16300	COG0850	regulation of cytokinetic process
I9190_16305	COG2894	cell division
I9190_16310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I9190_16330	COG1253	flavin adenine dinucleotide binding
I9190_16335	COG2851	Citrate transporter
I9190_16350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9190_16410	COG0306	phosphate transporter
I9190_16425	COG2852	Protein conserved in bacteria
I9190_16435	COG2814	Major facilitator Superfamily
I9190_16440	COG1566	PFAM secretion protein HlyD family protein
I9190_16445	COG2050	protein possibly involved in aromatic compounds catabolism
I9190_16455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9190_16465	COG0583	DNA-binding transcription factor activity
I9190_16480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I9190_16490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9190_16495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9190_16500	COG0713	ATP synthesis coupled electron transport
I9190_16510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9190_16515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I9190_16525	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I9190_16545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9190_16555	COG2205	protein histidine kinase activity
I9190_16560	COG0745	RESPONSE REGULATOR receiver
I9190_16575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I9190_16580	COG0431	NADPH-dependent FMN reductase
I9190_16585	COG0798	PFAM Bile acid sodium symporter
I9190_16595	COG0640	Transcriptional regulator
I9190_16655	COG0037	tRNA processing
I9190_16665	COG0248	Ppx GppA phosphatase
I9190_16685	COG0776	regulation of translation
I9190_16690	COG0072	phenylalanine-tRNA ligase activity
I9190_16735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I9190_16755	COG1238	metal cluster binding
I9190_16770	COG0625	glutathione transferase activity
I9190_16815	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_16825	COG1960	acyl-CoA dehydrogenase activity
I9190_16830	COG1960	acyl-CoA dehydrogenase activity
I9190_16905	COG3306	glycosyltransferase involved in LPS biosynthesis
I9190_16930	COG0438	transferase activity, transferring glycosyl groups
I9190_16955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I9190_16960	COG5002	protein histidine kinase activity
I9190_16965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9190_16975	COG5383	Protein conserved in bacteria
I9190_16980	COG1012	belongs to the aldehyde dehydrogenase family
I9190_16985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9190_16990	COG0277	FAD linked oxidase domain protein
I9190_16990	COG0247	lactate metabolic process
I9190_16995	COG0583	DNA-binding transcription factor activity
I9190_17000	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_17015	COG0583	DNA-binding transcription factor activity
I9190_17040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I9190_17070	COG1862	Preprotein translocase
I9190_17125	COG2814	Major facilitator Superfamily
I9190_17155	COG2814	Major facilitator Superfamily
I9190_17165	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_17175	COG0523	cobalamin synthesis protein
I9190_17190	COG2188	Transcriptional regulator
I9190_17200	COG0738	Major facilitator superfamily
I9190_17210	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_17220	COG4948	Mandelate Racemase Muconate Lactonizing
I9190_17230	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_17235	COG2186	Transcriptional regulator
I9190_17245	COG3958	Transketolase
I9190_17250	COG3959	Transketolase, thiamine diphosphate binding domain
I9190_17255	COG2271	Major facilitator Superfamily
I9190_17260	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_17265	COG0583	DNA-binding transcription factor activity
I9190_17285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_17290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I9190_17295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_17310	COG0183	Belongs to the thiolase family
I9190_17315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_17345	COG1484	DNA-dependent DNA replication
I9190_17350	COG1074	ATP-dependent DNA helicase activity
I9190_17365	COG2009	succinate dehydrogenase
I9190_17375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I9190_17385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I9190_17420	COG0625	glutathione transferase activity
I9190_17425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_17450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_17465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_17475	COG0732	type I restriction modification DNA specificity domain
I9190_17485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I9190_17565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9190_17590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I9190_17600	COG0084	hydrolase, TatD family'
I9190_17615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I9190_17640	COG2130	NADP-dependent
I9190_17645	COG1309	transcriptional regulator
I9190_17670	COG1979	alcohol dehydrogenase
I9190_17680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I9190_17695	COG0604	alcohol dehydrogenase
I9190_17695	COG3321	synthase
I9190_17700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I9190_17705	COG0583	DNA-binding transcription factor activity
I9190_17710	COG4221	oxidoreductase activity
I9190_17845	COG3539	Fimbrial protein
I9190_17855	COG3121	Chaperone
I9190_17865	COG3539	Fimbrial protein
I9190_17880	COG2198	Histidine kinase
I9190_17880	COG0784	Response regulator, receiver
I9190_17880	COG0643	Histidine kinase
I9190_17885	COG0840	transmembrane signaling receptor activity
I9190_17910	COG0442	prolyl-tRNA aminoacylation
I9190_17970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I9190_17975	COG0489	protein tyrosine kinase activity
I9190_18010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9190_18010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9190_18050	COG2853	Lipoprotein
I9190_18065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9190_18070	COG1846	Transcriptional regulator
I9190_18075	COG1764	response to oxidative stress
I9190_18110	COG3384	dioxygenase
I9190_18120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_18150	COG4206	TonB-dependent receptor
I9190_18155	COG2096	Adenosyltransferase
I9190_18175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I9190_18185	COG2315	Protein conserved in bacteria
I9190_18190	COG0745	RESPONSE REGULATOR receiver
I9190_18195	COG2205	protein histidine kinase activity
I9190_18205	COG3028	Belongs to the UPF0307 family
I9190_18210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I9190_18215	COG1660	Displays ATPase and GTPase activities
I9190_18220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I9190_18230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I9190_18235	COG0617	tRNA 3'-terminal CCA addition
I9190_18240	COG1555	photosystem II stabilization
I9190_18245	COG3956	TIGRFAM MazG family protein
I9190_18260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9190_18280	COG0784	Response regulator, receiver
I9190_18280	COG5002	protein histidine kinase activity
I9190_18280	COG2205	protein histidine kinase activity
I9190_18285	COG1024	Enoyl-CoA hydratase
I9190_18290	COG2084	Dehydrogenase
I9190_18295	COG3622	Belongs to the hyi family
I9190_18305	COG0004	ammonium transporteR
I9190_18340	COG1426	Protein conserved in bacteria
I9190_18345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I9190_18385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I9190_18390	COG0440	acetolactate synthase activity
I9190_18395	COG0028	Belongs to the TPP enzyme family
I9190_18400	COG1309	transcriptional regulator
I9190_18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_18435	COG1136	(ABC) transporter
I9190_18435	COG0577	efflux transmembrane transporter activity
I9190_18440	COG1538	Outer membrane efflux protein
I9190_18465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_18470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_18475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_18500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I9190_18505	COG1162	GTPase activity
I9190_18515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I9190_18550	COG3783	Cytochrome b(562)
I9190_18555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I9190_18560	COG2003	Belongs to the UPF0758 family
I9190_18565	COG3781	membrane
I9190_18600	COG1946	Acyl-CoA thioesterase
I9190_18620	COG1295	ribonuclease BN
I9190_18625	COG0697	spore germination
I9190_18655	COG0179	Fumarylacetoacetate (FAA) hydrolase
I9190_18680	COG2814	Major facilitator Superfamily
I9190_18690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9190_18695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9190_18705	COG0765	amino acid transport
I9190_18710	COG0765	amino acid transport
I9190_18740	COG0557	exoribonuclease II activity
I9190_18755	COG0339	signal peptide processing
I9190_18760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I9190_18805	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I9190_18810	COG1960	acyl-CoA dehydrogenase activity
I9190_18815	COG2072	flavoprotein involved in K transport
I9190_18820	COG0203	ribosomal protein L17
I9190_18825	COG0202	RNA polymerase activity
I9190_18830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I9190_18840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I9190_18865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I9190_18880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I9190_18900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I9190_18930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I9190_18945	COG0088	Forms part of the polypeptide exit tunnel
I9190_18950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I9190_18955	COG0051	transcription antitermination factor activity, RNA binding
I9190_18965	COG0626	cystathionine gamma-synthase activity
I9190_18970	COG0433	COG0433 Predicted ATPase
I9190_18975	COG1017	nitric oxide dioxygenase activity
I9190_18975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I9190_18985	COG1959	2 iron, 2 sulfur cluster binding
I9190_19000	COG1301	dicarboxylic acid transport
I9190_19005	COG1946	Acyl-CoA thioesterase
I9190_19010	COG2937	Belongs to the GPAT DAPAT family
I9190_19020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I9190_19025	COG1040	competence protein
I9190_19030	COG0494	nUDIX hydrolase
I9190_19040	COG0598	Magnesium transport protein CorA
I9190_19055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9190_19060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I9190_19065	COG1127	ABC transporter
I9190_19070	COG0513	Belongs to the DEAD box helicase family
I9190_19085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9190_19090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9190_19095	COG0408	coproporphyrinogen oxidase activity
I9190_19115	COG1960	acyl-CoA dehydrogenase activity
I9190_19125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9190_19135	COG0534	Mate efflux family protein
I9190_19145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9190_19150	COG0254	rRNA binding
I9190_19155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I9190_19185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I9190_19225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9190_19240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I9190_19250	COG0644	oxidoreductase
I9190_19250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I9190_19270	COG0425	Belongs to the sulfur carrier protein TusA family
I9190_19275	COG4535	Mg2 and Co2 transporter CorC
I9190_19280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I9190_19285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9190_19310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I9190_19320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I9190_19335	COG0789	Transcriptional regulator
I9190_19340	COG2841	Protein conserved in bacteria
I9190_19345	COG0598	Magnesium transport protein CorA
I9190_19360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I9190_19365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_19370	COG1074	ATP-dependent DNA helicase activity
I9190_19375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I9190_19400	COG2226	methyltransferase
I9190_19410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9190_19425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I9190_19445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9190_19445	COG2111	Na H antiporter
I9190_19450	COG1006	Multisubunit Na H antiporter MnhC subunit
I9190_19455	COG0651	ATP synthesis coupled electron transport
I9190_19460	COG1863	multisubunit Na H antiporter MnhE subunit
I9190_19465	COG2212	antiporter activity
I9190_19470	COG1320	monovalent cation:proton antiporter activity
I9190_19475	COG0307	riboflavin synthase, alpha
I9190_19485	COG0493	'glutamate synthase
I9190_19490	COG0067	glutamate synthase
I9190_19490	COG0069	glutamate synthase activity
I9190_19490	COG0070	glutamate synthase
I9190_19540	COG2226	methyltransferase
I9190_19545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I9190_19550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I9190_19555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I9190_19595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9190_19675	COG4221	oxidoreductase activity
I9190_19680	COG0583	DNA-binding transcription factor activity
I9190_19690	COG3320	Male sterility
I9190_19690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9190_19695	COG0789	Transcriptional regulator
I9190_19720	COG0427	acetyl-CoA hydrolase
I9190_19765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I9190_19800	COG0697	spore germination
I9190_19815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I9190_19830	COG0488	(ABC) transporter
I9190_19845	COG0704	Plays a role in the regulation of phosphate uptake
I9190_19870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9190_19875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I9190_19880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9190_19885	COG0772	Belongs to the SEDS family
I9190_19895	COG0586	Pfam SNARE associated Golgi protein
I9190_19910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9190_19910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9190_19920	COG0004	ammonium transporteR
I9190_19925	COG0347	Belongs to the P(II) protein family
I9190_19935	COG0606	chelatase, subunit chli
I9190_19990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I9190_20005	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_20020	COG0477	Major facilitator Superfamily
I9190_20030	COG2860	membrane
I9190_20040	COG1253	flavin adenine dinucleotide binding
I9190_20085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9190_20095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9190_20100	COG3162	membrane
I9190_20105	COG2205	protein histidine kinase activity
I9190_20105	COG0784	Response regulator, receiver
I9190_20125	COG2133	pyrroloquinoline quinone binding
I9190_20165	COG1309	transcriptional regulator
I9190_20185	COG4771	TonB-dependent receptor
I9190_20200	COG1652	LysM domain
I9190_20205	COG0758	DNA mediated transformation
I9190_20210	COG0009	L-threonylcarbamoyladenylate synthase
I9190_20215	COG0697	spore germination
I9190_20220	COG1309	transcriptional regulator
I9190_20240	COG0386	Belongs to the glutathione peroxidase family
I9190_20275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I9190_20285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I9190_20305	COG0356	it plays a direct role in the translocation of protons across the membrane
I9190_20325	COG1121	(ABC) transporter
I9190_20330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I9190_20345	COG2837	iron assimilation
I9190_20385	COG0281	malic enzyme
I9190_20415	COG0745	RESPONSE REGULATOR receiver
I9190_20420	COG2205	protein histidine kinase activity
I9190_20425	COG4452	Inner membrane protein CreD
I9190_20450	COG2814	Major facilitator Superfamily
I9190_20460	COG0431	NADPH-dependent FMN reductase
I9190_20480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9190_20490	COG0668	transmembrane transport
I9190_20495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9190_20500	COG1519	Transferase
I9190_20505	COG1902	pentaerythritol trinitrate reductase activity
I9190_20525	COG1715	Restriction endonuclease
I9190_20530	COG0519	Catalyzes the synthesis of GMP from XMP
I9190_20530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9190_20540	COG2259	Doxx family
I9190_20545	COG0586	Pfam SNARE associated Golgi protein
I9190_20555	COG1192	Involved in chromosome partitioning
I9190_20565	COG0271	Belongs to the BolA IbaG family
I9190_20585	COG0235	Class ii aldolase
I9190_20590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I9190_20605	COG1454	alcohol dehydrogenase
I9190_20640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9190_20645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9190_20660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I9190_20665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I9190_20670	COG1216	Glycosyl transferase, family 2
I9190_20700	COG2244	polysaccharide biosynthetic process
I9190_20725	COG1596	polysaccharide export
I9190_20755	COG3023	N-Acetylmuramoyl-L-alanine amidase
I9190_20845	COG1196	nuclear chromosome segregation
I9190_20845	COG0739	heme binding
I9190_20845	COG0741	lytic transglycosylase activity
I9190_21005	COG0582	viral genome integration into host DNA
I9190_21010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I9190_21020	COG2207	Transcriptional regulator
I9190_21040	COG1309	transcriptional regulator
I9190_21055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I9190_21060	COG0546	phosphoglycolate phosphatase activity
I9190_21065	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_21090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I9190_21090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I9190_21095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_21100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_21105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_21110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9190_21115	COG1116	anion transmembrane transporter activity
I9190_21120	COG1309	transcriptional regulator
I9190_21260	COG0737	Belongs to the 5'-nucleotidase family
I9190_21265	COG2175	clavaminate synthase activity
I9190_21270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9190_21275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I9190_21280	COG4521	taurine ABC transporter
I9190_21300	COG0443	Heat shock 70 kDa protein
I9190_21340	COG2951	lytic endotransglycosylase activity
I9190_21345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I9190_21370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9190_21380	COG2388	GCN5-related N-acetyl-transferase
I9190_21385	COG2388	GCN5-related N-acetyl-transferase
I9190_21390	COG2814	Major facilitator Superfamily
I9190_21395	COG1335	isochorismatase
I9190_21400	COG0861	Integral membrane protein TerC family
I9190_21415	COG0754	glutathionylspermidine amidase activity
I9190_21425	COG0402	S-adenosylhomocysteine deaminase activity
I9190_21435	COG2261	transglycosylase associated protein
I9190_21445	COG1230	cation diffusion facilitator family transporter
I9190_21470	COG0629	single-stranded DNA binding
I9190_21520	COG0706	membrane insertase activity
I9190_21525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I9190_21530	COG0594	ribonuclease P activity
I9190_21595	COG1373	ATPase (AAA superfamily
I9190_21640	COG1192	Involved in chromosome partitioning
I9190_21655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_21665	COG0732	type I restriction modification DNA specificity domain
I9190_21670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I9190_21675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I9190_21725	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I9190_21735	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I9190_21755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9190_21815	COG1538	Outer membrane efflux protein
I9190_21820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_21830	COG0745	RESPONSE REGULATOR receiver
I9190_21835	COG2205	protein histidine kinase activity
I9190_21850	COG3173	Aminoglycoside phosphotransferase
I9190_21855	COG0488	(ABC) transporter
I9190_21860	COG2801	Transposase and inactivated derivatives
I9190_21880	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_21885	COG3657	addiction module killer protein
I9190_21940	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_21945	COG3657	addiction module killer protein
I9190_21955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I9190_21995	COG0210	DNA helicase
I9190_22015	COG0210	DNA helicase
I9190_22070	COG0582	viral genome integration into host DNA
I9190_22075	COG2369	cell adhesion
I9190_22120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair