locus-tag	class	description
AS4_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS4_00020	COG0592	DNA-directed DNA polymerase activity
AS4_00040	COG0187	DNA topoisomerase II activity
AS4_00060	COG0488	(ABC) transporter
AS4_00080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS4_00090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AS4_00170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS4_00210	COG1012	belongs to the aldehyde dehydrogenase family
AS4_00220	COG3738	Protein conserved in bacteria
AS4_00230	COG0733	neurotransmitter:sodium symporter activity
AS4_00250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS4_00250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS4_00260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS4_00280	COG2885	chlorophyll binding
AS4_00280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AS4_00300	COG0129	dihydroxy-acid dehydratase activity
AS4_00340	COG0174	glutamine synthetase
AS4_00370	COG1794	racemase activity, acting on amino acids and derivatives
AS4_00380	COG1047	Peptidyl-prolyl cis-trans
AS4_00390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AS4_00400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS4_00410	COG0196	riboflavin kinase activity
AS4_00440	COG2233	PERMEase
AS4_00450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS4_00460	COG1309	transcriptional regulator
AS4_00550	COG2814	Major facilitator Superfamily
AS4_00560	COG0656	L-ascorbic acid biosynthetic process
AS4_00570	COG0583	DNA-binding transcription factor activity
AS4_00600	COG1064	alcohol dehydrogenase
AS4_00610	COG2818	Glycosylase
AS4_00640	COG1194	a g-specific adenine glycosylase
AS4_00670	COG5487	UPF0391 membrane protein
AS4_00680	COG2983	Belongs to the UPF0260 family
AS4_00700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS4_00790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS4_00800	COG1335	isochorismatase
AS4_00810	COG0385	Bile acid
AS4_00820	COG1683	Conserved Protein
AS4_00840	COG0778	Nitroreductase
AS4_00850	COG1309	transcriptional regulator
AS4_00870	COG0640	Transcriptional regulator
AS4_00890	COG1230	cation diffusion facilitator family transporter
AS4_00900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS4_00920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS4_00930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AS4_00940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS4_00950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS4_00980	COG3830	Belongs to the UPF0237 family
AS4_00980	COG0560	Phosphoserine phosphatase
AS4_01120	COG0534	Mate efflux family protein
AS4_01130	COG0436	Aminotransferase
AS4_01230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS4_01270	COG2733	membrane
AS4_01310	COG2918	glutathione biosynthetic process
AS4_01320	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS4_01350	COG3150	esterase
AS4_01380	COG0559	Belongs to the binding-protein-dependent transport system permease family
AS4_01410	COG0410	ABC transporter
AS4_01500	COG3706	GGDEF domain
AS4_01500	COG0745	RESPONSE REGULATOR receiver
AS4_01510	COG3706	GGDEF domain
AS4_01540	COG1393	Belongs to the ArsC family
AS4_01550	COG0708	Exodeoxyribonuclease III
AS4_01580	COG2720	vancomycin resistance protein
AS4_01590	COG2226	methyltransferase
AS4_01610	COG0189	ligase activity
AS4_01630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS4_01650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS4_01680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AS4_01730	COG2119	membrane
AS4_01740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_01740	COG0426	domain, Protein
AS4_01800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AS4_01900	COG2267	carboxylic ester hydrolase activity
AS4_01910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_01950	COG0351	phosphomethylpyrimidine kinase
AS4_01950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS4_01950	COG0352	thiamine-phosphate diphosphorylase activity
AS4_01970	COG2814	Major facilitator Superfamily
AS4_01980	COG0629	single-stranded DNA binding
AS4_02020	COG0450	alkyl hydroperoxide reductase
AS4_02030	COG0583	DNA-binding transcription factor activity
AS4_02040	COG1335	isochorismatase
AS4_02060	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AS4_02100	COG3177	Filamentation induced by cAMP protein fic
AS4_02190	COG3158	transport of potassium into the cell
AS4_02230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS4_02270	COG0165	Argininosuccinate lyase
AS4_02280	COG3275	phosphorelay sensor kinase activity
AS4_02300	COG0181	hydroxymethylbilane synthase activity
AS4_02430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS4_02460	COG0081	regulation of translation
AS4_02480	COG0222	ribosome binding
AS4_02490	COG0085	RNA polymerase activity
AS4_02500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS4_02550	COG2056	Na+-H+ antiporter family
AS4_02580	COG0326	Molecular chaperone. Has ATPase activity
AS4_02610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS4_02670	COG0183	Belongs to the thiolase family
AS4_02680	COG1024	Enoyl-CoA hydratase
AS4_02680	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_02760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS4_02820	COG0795	lipopolysaccharide-transporting ATPase activity
AS4_02830	COG0795	lipopolysaccharide-transporting ATPase activity
AS4_02840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AS4_02850	COG0793	Belongs to the peptidase S41A family
AS4_02880	COG2197	response regulator
AS4_02890	COG1686	Belongs to the peptidase S11 family
AS4_02920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS4_02950	COG4974	Belongs to the 'phage' integrase family
AS4_02990	COG1132	(ABC) transporter
AS4_03010	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS4_03030	COG1289	transmembrane transporter activity
AS4_03050	COG1566	PFAM secretion protein HlyD family protein
AS4_03070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AS4_03090	COG0497	DNA recombination
AS4_03100	COG3123	guanosine phosphorylase activity
AS4_03110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS4_03130	COG0237	dephospho-CoA kinase activity
AS4_03140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AS4_03190	COG0779	Required for maturation of 30S ribosomal subunits
AS4_03200	COG0195	Participates in both transcription termination and antitermination
AS4_03210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AS4_03220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AS4_03240	COG1704	LemA family
AS4_03250	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AS4_03300	COG3307	-O-antigen
AS4_03340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS4_03350	COG1758	RNA polymerase activity
AS4_03360	COG0194	GDP metabolic process
AS4_03380	COG4968	Prepilin-type N-terminal cleavage methylation domain
AS4_03440	COG4969	Belongs to the N-Me-Phe pilin family
AS4_03450	COG0228	four-way junction DNA binding
AS4_03460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS4_03480	COG0335	large ribosomal subunit rRNA binding
AS4_03510	COG5380	lipid catabolic process
AS4_03520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS4_03570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS4_03590	COG5006	permease, DMT superfamily
AS4_03600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS4_03610	COG0277	FAD linked oxidase domain protein
AS4_03640	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS4_03690	COG2814	Major facilitator Superfamily
AS4_03710	COG1289	transmembrane transporter activity
AS4_03730	COG2032	superoxide dismutase activity
AS4_03740	COG0628	permease
AS4_03860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS4_03940	COG0751	glycine-tRNA ligase activity
AS4_04000	COG0277	FAD linked oxidase domain protein
AS4_04030	COG0517	IMP dehydrogenase activity
AS4_04040	COG1983	PspC domain protein
AS4_04080	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_04090	COG1530	ribonuclease E activity
AS4_04100	COG0564	pseudouridine synthase activity
AS4_04110	COG0546	phosphoglycolate phosphatase activity
AS4_04120	COG2378	regulation of single-species biofilm formation
AS4_04150	COG0583	DNA-binding transcription factor activity
AS4_04230	COG0753	catalase activity
AS4_04310	COG1960	acyl-CoA dehydrogenase activity
AS4_04390	COG0494	nUDIX hydrolase
AS4_04420	COG0583	DNA-binding transcription factor activity
AS4_04450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS4_04480	COG0473	3-isopropylmalate dehydrogenase activity
AS4_04500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS4_04540	COG0252	asparaginase activity
AS4_04610	COG1560	Kdo2-lipid A biosynthetic process
AS4_04670	COG0583	DNA-binding transcription factor activity
AS4_04680	COG1914	H( )-stimulated, divalent metal cation uptake system
AS4_04710	COG1984	allophanate hydrolase subunit 2
AS4_04720	COG4770	biotin carboxylase activity
AS4_04740	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_04750	COG1733	regulation of RNA biosynthetic process
AS4_04820	COG1929	Belongs to the glycerate kinase type-1 family
AS4_04840	COG0210	DNA helicase
AS4_04880	COG4651	solute:proton antiporter activity
AS4_04880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS4_04890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AS4_04900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AS4_04930	COG0788	formyltetrahydrofolate deformylase activity
AS4_04980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS4_04980	COG3453	Protein conserved in bacteria
AS4_05010	COG1607	acyl-coa hydrolase
AS4_05040	COG1666	GTP binding
AS4_05050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS4_05080	COG2350	Protein conserved in bacteria
AS4_05100	COG0613	PHP domain protein
AS4_05120	COG1702	phosphate starvation-inducible protein PhoH
AS4_05130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS4_05140	COG0739	heme binding
AS4_05140	COG0741	lytic transglycosylase activity
AS4_05140	COG1196	nuclear chromosome segregation
AS4_05160	COG0039	L-malate dehydrogenase activity
AS4_05200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AS4_05210	COG1183	phosphatidylcholine synthase activity
AS4_05280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS4_05290	COG3878	Protein conserved in bacteria
AS4_05370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS4_05400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS4_05440	COG2813	Specifically methylates the guanine in position
AS4_05440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS4_05460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS4_05490	COG4774	siderophore transport
AS4_05520	COG0740	serine-type endopeptidase activity
AS4_05600	COG0280	phosphate acetyltransferase
AS4_05600	COG0857	belongs to the CobB CobQ family
AS4_05610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS4_05660	COG0793	Belongs to the peptidase S41A family
AS4_05680	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AS4_05710	COG0084	hydrolase, TatD family'
AS4_05730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS4_05770	COG0583	DNA-binding transcription factor activity
AS4_05780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS4_05820	COG0583	DNA-binding transcription factor activity
AS4_05860	COG1609	Transcriptional regulator
AS4_05870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS4_05890	COG0154	amidase activity
AS4_05930	COG0668	transmembrane transport
AS4_05980	COG2814	Major facilitator Superfamily
AS4_06040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AS4_06050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AS4_06060	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AS4_06100	COG1862	Preprotein translocase
AS4_06150	COG3201	nicotinamide mononucleotide transporter
AS4_06190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AS4_06610	COG4695	Portal protein
AS4_06640	COG2205	protein histidine kinase activity
AS4_06650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AS4_06700	COG0438	transferase activity, transferring glycosyl groups
AS4_06740	COG3306	glycosyltransferase involved in LPS biosynthesis
AS4_06750	COG3306	glycosyltransferase involved in LPS biosynthesis
AS4_06760	COG2755	lipolytic protein G-D-S-L family
AS4_06760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS4_06820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS4_06950	COG1960	acyl-CoA dehydrogenase activity
AS4_06960	COG1960	acyl-CoA dehydrogenase activity
AS4_06980	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_07010	COG0277	FAD linked oxidase domain protein
AS4_07040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AS4_07060	COG0625	glutathione transferase activity
AS4_07090	COG1238	metal cluster binding
AS4_07120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS4_07130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AS4_07200	COG0072	phenylalanine-tRNA ligase activity
AS4_07210	COG0776	regulation of translation
AS4_07250	COG0248	Ppx GppA phosphatase
AS4_07270	COG0037	tRNA processing
AS4_07320	COG0183	Belongs to the thiolase family
AS4_07340	COG2885	chlorophyll binding
AS4_07340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AS4_07370	COG1690	Belongs to the RtcB family
AS4_07390	COG0833	amino acid
AS4_07410	COG2233	PERMEase
AS4_07430	COG1970	mechanosensitive ion channel activity
AS4_07450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS4_07470	COG3659	wide pore channel activity
AS4_07480	COG4772	TonB-dependent receptor
AS4_07490	COG1902	pentaerythritol trinitrate reductase activity
AS4_07520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS4_07580	COG0354	folic acid binding
AS4_07590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS4_07660	COG5001	Diguanylate cyclase
AS4_07660	COG3447	MASE1 domain protein
AS4_07660	COG5002	protein histidine kinase activity
AS4_07700	COG2969	positive regulation of protein catabolic process
AS4_07710	COG0625	glutathione transferase activity
AS4_07730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AS4_07740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS4_07770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AS4_07780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS4_07790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS4_07840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS4_07860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS4_07870	COG1408	metallophosphoesterase
AS4_07930	COG2824	Alkylphosphonate utilization operon protein PhnA
AS4_07940	COG2197	response regulator
AS4_07950	COG0477	Major facilitator Superfamily
AS4_08000	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AS4_08020	COG4166	transmembrane transport
AS4_08030	COG4166	transmembrane transport
AS4_08060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS4_08100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS4_08110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AS4_08130	COG3501	Rhs element vgr protein
AS4_08180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS4_08190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_08220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS4_08270	COG3328	transposase activity
AS4_08290	COG3328	transposase activity
AS4_08420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS4_08440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS4_08440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS4_08450	COG0745	RESPONSE REGULATOR receiver
AS4_08460	COG2205	protein histidine kinase activity
AS4_08510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS4_08550	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AS4_08570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AS4_08580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS4_08600	COG0713	ATP synthesis coupled electron transport
AS4_08610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS4_08620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS4_08640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS4_08670	COG0583	DNA-binding transcription factor activity
AS4_08710	COG2050	protein possibly involved in aromatic compounds catabolism
AS4_08720	COG1566	PFAM secretion protein HlyD family protein
AS4_08730	COG2814	Major facilitator Superfamily
AS4_08750	COG3177	Filamentation induced by cAMP protein fic
AS4_08770	COG5295	Hep Hag repeat protein
AS4_08770	COG5295	Hep Hag repeat protein
AS4_08780	COG0306	phosphate transporter
AS4_08810	COG0175	sulfate reduction
AS4_08880	COG2851	Citrate transporter
AS4_08890	COG1253	flavin adenine dinucleotide binding
AS4_08930	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AS4_08940	COG2894	cell division
AS4_08950	COG0850	regulation of cytokinetic process
AS4_08970	COG0204	Acyl-transferase
AS4_08980	COG2885	chlorophyll binding
AS4_09000	COG0756	dUTP diphosphatase activity
AS4_09010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS4_09020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS4_09040	COG0121	glutamine amidotransferase
AS4_09070	COG2914	Belongs to the UPF0125 (RnfH) family
AS4_09080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS4_09090	COG0735	belongs to the Fur family
AS4_09130	COG1968	undecaprenyl-diphosphatase activity
AS4_09190	COG0420	3'-5' exonuclease activity
AS4_09260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS4_09300	COG0786	glutamate:sodium symporter activity
AS4_09310	COG2059	Chromate
AS4_09320	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS4_09330	COG1607	acyl-coa hydrolase
AS4_09380	COG0523	cobalamin synthesis protein
AS4_09390	COG4681	YaeQ
AS4_09430	COG1649	PFAM Uncharacterised BCR, COG1649
AS4_09430	COG0726	polysaccharide deacetylase
AS4_09440	COG1215	transferase activity, transferring glycosyl groups
AS4_09510	COG1309	transcriptional regulator
AS4_09530	COG1024	Enoyl-CoA hydratase
AS4_09560	COG4771	TonB-dependent receptor
AS4_09620	COG1113	amino acid transport
AS4_09630	COG2828	Protein conserved in bacteria
AS4_09640	COG2199	diguanylate cyclase activity
AS4_09640	COG2203	Gaf domain
AS4_09650	COG0142	geranyltranstransferase activity
AS4_09680	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS4_09700	COG2814	Major facilitator Superfamily
AS4_09710	COG2194	sulfuric ester hydrolase activity
AS4_09730	COG0642	Histidine kinase
AS4_09760	COG0004	ammonium transporteR
AS4_09850	COG0525	valine-tRNA ligase activity
AS4_09870	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_09910	COG0393	Putative heavy-metal-binding
AS4_09920	COG1538	Outer membrane efflux protein
AS4_09940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_09950	COG0671	phosphoesterase, PA-phosphatase related
AS4_09980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AS4_10010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS4_10020	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AS4_10030	COG2072	flavoprotein involved in K transport
AS4_10080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AS4_10090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS4_10090	COG1648	precorrin-2 dehydrogenase activity
AS4_10100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS4_10140	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_10160	COG0531	amino acid
AS4_10190	COG0321	lipoyl(octanoyl) transferase activity
AS4_10200	COG2921	Belongs to the UPF0250 family
AS4_10240	COG1280	lysine exporter protein (LysE YggA)
AS4_10250	COG0586	Pfam SNARE associated Golgi protein
AS4_10280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS4_10330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AS4_10340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS4_10420	COG0564	pseudouridine synthase activity
AS4_10510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS4_10520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS4_10530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS4_10600	COG0477	Major facilitator Superfamily
AS4_10650	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AS4_10660	COG1597	lipid kinase activity
AS4_10690	COG0459	protein refolding
AS4_10720	COG0584	glycerophosphoryl diester phosphodiesterase
AS4_10730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_10740	COG2239	Acts as a magnesium transporter
AS4_10770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS4_10780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS4_10790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS4_10830	COG1113	amino acid transport
AS4_10850	COG0019	diaminopimelate decarboxylase activity
AS4_10900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS4_10920	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
AS4_10940	COG0833	amino acid
AS4_10950	COG0833	amino acid
AS4_10960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS4_10970	COG0418	dihydroorotase activity
AS4_11010	COG0501	Belongs to the peptidase M48B family
AS4_11020	COG0741	lytic transglycosylase activity
AS4_11030	COG0037	tRNA processing
AS4_11050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AS4_11060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS4_11090	COG3220	belongs to the UPF0276 family
AS4_11110	COG1595	DNA-templated transcription, initiation
AS4_11160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AS4_11190	COG0642	Histidine kinase
AS4_11230	COG4771	TonB-dependent receptor
AS4_11250	COG1595	DNA-templated transcription, initiation
AS4_11280	COG0477	Major facilitator Superfamily
AS4_11320	COG1309	transcriptional regulator
AS4_11420	COG3188	usher protein
AS4_11460	COG1598	PFAM Uncharacterised protein family UPF0150
AS4_11470	COG3539	Fimbrial protein
AS4_11560	COG2207	Transcriptional regulator
AS4_11600	COG3121	Chaperone
AS4_11620	COG3539	Fimbrial protein
AS4_11680	COG1116	anion transmembrane transporter activity
AS4_11680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_11700	COG2223	nitrite transmembrane transporter activity
AS4_11710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_11720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_11730	COG0243	molybdopterin cofactor binding
AS4_11760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS4_11780	COG0314	molybdopterin synthase activity
AS4_11790	COG1414	Transcriptional regulator
AS4_11800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS4_11810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_11820	COG0183	Belongs to the thiolase family
AS4_11830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS4_11840	COG0596	Alpha beta hydrolase
AS4_11850	COG2271	Major facilitator Superfamily
AS4_11860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS4_11870	COG3485	protocatechuate 3,4-dioxygenase
AS4_11880	COG3485	protocatechuate 3,4-dioxygenase
AS4_11890	COG0710	3-dehydroquinate dehydratase activity
AS4_11900	COG3420	alginic acid biosynthetic process
AS4_11910	COG3659	wide pore channel activity
AS4_11920	COG4993	Dehydrogenase
AS4_11930	COG0789	Transcriptional regulator
AS4_11940	COG2217	Heavy metal translocating P-type atpase
AS4_11970	COG2205	protein histidine kinase activity
AS4_12000	COG1923	regulation of RNA biosynthetic process
AS4_12020	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AS4_12030	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AS4_12050	COG2205	protein histidine kinase activity
AS4_12060	COG0745	RESPONSE REGULATOR receiver
AS4_12100	COG1073	alpha beta
AS4_12110	COG0583	DNA-binding transcription factor activity
AS4_12170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS4_12240	COG0006	proline dipeptidase activity
AS4_12260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_12270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_12360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS4_12370	COG1388	LysM domain
AS4_12370	COG0741	lytic transglycosylase activity
AS4_12380	COG4166	transmembrane transport
AS4_12390	COG4174	ABC transporter (Permease)
AS4_12400	COG4239	(ABC) transporter, permease
AS4_12410	COG4172	Belongs to the ABC transporter superfamily
AS4_12470	COG0024	Methionine aminopeptidase
AS4_12480	COG0052	Belongs to the universal ribosomal protein uS2 family
AS4_12490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS4_12600	COG2951	lytic endotransglycosylase activity
AS4_12610	COG0772	Belongs to the SEDS family
AS4_12640	COG0842	Transport permease protein
AS4_12650	COG1131	(ABC) transporter
AS4_12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS4_12670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS4_12780	COG1476	TRANSCRIPTIONal
AS4_13010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS4_13040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AS4_13080	COG2233	PERMEase
AS4_13100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_13160	COG0612	Peptidase, M16
AS4_13190	COG1720	tRNA m6t6A37 methyltransferase activity
AS4_13230	COG0352	thiamine-phosphate diphosphorylase activity
AS4_13320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS4_13330	COG3111	PFAM Bacterial OB fold (BOF) protein
AS4_13340	COG0745	RESPONSE REGULATOR receiver
AS4_13350	COG0642	Histidine kinase
AS4_13370	COG0494	nUDIX hydrolase
AS4_13390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS4_13400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS4_13410	COG3139	Protein of unknown function (DUF1315)
AS4_13430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS4_13440	COG1301	dicarboxylic acid transport
AS4_13460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS4_13480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS4_13540	COG2318	DinB family
AS4_13550	COG2070	2-Nitropropane dioxygenase
AS4_13650	COG0450	alkyl hydroperoxide reductase
AS4_13660	COG1643	Atp-dependent helicase
AS4_13730	COG2831	hemolysin activation secretion protein
AS4_13740	COG2188	Transcriptional regulator
AS4_13780	COG1113	amino acid transport
AS4_13810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS4_13850	COG3706	GGDEF domain
AS4_13870	COG2072	flavoprotein involved in K transport
AS4_13880	COG0300	oxidoreductase activity
AS4_13890	COG1280	lysine exporter protein (LysE YggA)
AS4_13920	COG1136	(ABC) transporter
AS4_13930	COG2333	competence protein COMEC
AS4_13930	COG0658	competence protein
AS4_13970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS4_13990	COG0628	permease
AS4_14080	COG3634	alkyl hydroperoxide reductase activity
AS4_14090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS4_14100	COG0583	DNA-binding transcription factor activity
AS4_14110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS4_14140	COG0640	Transcriptional regulator
AS4_14150	COG0798	PFAM Bile acid sodium symporter
AS4_14160	COG0789	Transcriptional regulator
AS4_14250	COG1022	Amp-dependent synthetase and ligase
AS4_14350	COG4772	TonB-dependent receptor
AS4_14370	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS4_14380	COG0076	glutamate decarboxylase activity
AS4_14400	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AS4_14430	COG0582	viral genome integration into host DNA
AS4_14480	COG1012	belongs to the aldehyde dehydrogenase family
AS4_14490	COG3268	Saccharopine dehydrogenase
AS4_14520	COG0753	catalase activity
AS4_14530	COG0113	porphobilinogen synthase activity
AS4_14580	COG0789	Transcriptional regulator
AS4_14600	COG3231	kanamycin kinase activity
AS4_14630	COG1960	acyl-CoA dehydrogenase activity
AS4_14640	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_14650	COG3829	transcription factor binding
AS4_14710	COG1846	Transcriptional regulator
AS4_14750	COG3539	Fimbrial protein
AS4_14780	COG3539	Fimbrial protein
AS4_14800	COG2197	response regulator
AS4_14810	COG0784	Response regulator, receiver
AS4_14810	COG2205	protein histidine kinase activity
AS4_14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_14810	COG2198	Histidine kinase
AS4_14840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS4_14850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS4_14860	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS4_14860	COG0315	cyclic pyranopterin monophosphate synthase activity
AS4_14870	COG0303	'Molybdopterin
AS4_14910	COG0243	molybdopterin cofactor binding
AS4_14920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS4_14930	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS4_14940	COG4149	molybdate abc transporter
AS4_14960	COG0443	Heat shock 70 kDa protein
AS4_14980	COG2831	hemolysin activation secretion protein
AS4_14990	COG2994	toxin metabolic process
AS4_15000	COG3210	domain, Protein
AS4_15010	COG3210	domain, Protein
AS4_15130	COG2801	Transposase and inactivated derivatives
AS4_15140	COG1522	sequence-specific DNA binding
AS4_15170	COG1234	tRNA 3'-trailer cleavage
AS4_15240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_15270	COG0543	2 iron, 2 sulfur cluster binding
AS4_15270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_15280	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AS4_15290	COG4638	Rieske (2fe-2S)
AS4_15320	COG2814	Major facilitator Superfamily
AS4_15350	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_15370	COG0154	amidase activity
AS4_15400	COG4638	Rieske (2fe-2S)
AS4_15420	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_15440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_15460	COG3733	amine oxidase
AS4_15480	COG1012	belongs to the aldehyde dehydrogenase family
AS4_15500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS4_15510	COG0183	Belongs to the thiolase family
AS4_15520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_15530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS4_15540	COG4829	muconolactone delta-isomerase
AS4_15550	COG4948	Mandelate Racemase Muconate Lactonizing
AS4_15560	COG0583	DNA-binding transcription factor activity
AS4_15570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS4_15580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS4_15590	COG3485	protocatechuate 3,4-dioxygenase
AS4_15620	COG1294	oxidase, subunit
AS4_15630	COG1271	oxidase subunit
AS4_15640	COG1380	Effector of murein hydrolase LrgA
AS4_15650	COG1346	cytolysis
AS4_15700	COG1172	Belongs to the binding-protein-dependent transport system permease family
AS4_15740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS4_15760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AS4_15810	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AS4_15810	COG0644	oxidoreductase
AS4_15820	COG2814	Major facilitator Superfamily
AS4_15830	COG1960	acyl-CoA dehydrogenase activity
AS4_15840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS4_15880	COG2814	Major facilitator Superfamily
AS4_15900	COG0183	Belongs to the thiolase family
AS4_15910	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_15930	COG1024	Enoyl-CoA hydratase
AS4_15940	COG1960	acyl-CoA dehydrogenase activity
AS4_15950	COG2814	Major facilitator Superfamily
AS4_15960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS4_15970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_15990	COG2814	Major facilitator Superfamily
AS4_16010	COG1960	acyl-CoA dehydrogenase activity
AS4_16020	COG1024	Enoyl-CoA hydratase
AS4_16040	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_16050	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_16060	COG2610	gluconate transmembrane transporter activity
AS4_16070	COG0583	DNA-binding transcription factor activity
AS4_16090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_16120	COG3836	Belongs to the HpcH HpaI aldolase family
AS4_16130	COG4264	IucA IucC family
AS4_16150	COG4264	IucA IucC family
AS4_16160	COG2423	ornithine cyclodeaminase activity
AS4_16170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS4_16180	COG3501	Rhs element vgr protein
AS4_16190	COG3209	COG3209 Rhs family protein
AS4_16210	COG3209	COG3209 Rhs family protein
AS4_16320	COG0583	DNA-binding transcription factor activity
AS4_16330	COG0473	3-isopropylmalate dehydrogenase activity
AS4_16360	COG4638	Rieske (2fe-2S)
AS4_16370	COG1012	belongs to the aldehyde dehydrogenase family
AS4_16410	COG2871	sodium ion transport
AS4_16490	COG5002	protein histidine kinase activity
AS4_16500	COG0745	RESPONSE REGULATOR receiver
AS4_16510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_16550	COG2832	Protein of unknown function (DUF454)
AS4_16580	COG1595	DNA-templated transcription, initiation
AS4_16690	COG3706	GGDEF domain
AS4_16690	COG0745	RESPONSE REGULATOR receiver
AS4_16700	COG0745	RESPONSE REGULATOR receiver
AS4_16700	COG3706	GGDEF domain
AS4_16720	COG0556	nucleotide-excision repair
AS4_16740	COG2962	Rard protein
AS4_16800	COG0702	epimerase
AS4_16810	COG1733	regulation of RNA biosynthetic process
AS4_16840	COG2915	High frequency lysogenization protein hflD homolog
AS4_16880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS4_16890	COG1686	Belongs to the peptidase S11 family
AS4_16950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS4_16960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AS4_16970	COG1067	ATP-dependent peptidase activity
AS4_17040	COG1509	lysine 2,3-aminomutase activity
AS4_17050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS4_17060	COG1966	Carbon starvation protein
AS4_17070	COG2879	small protein
AS4_17090	COG0714	Associated with various cellular activities
AS4_17590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_17660	COG5487	UPF0391 membrane protein
AS4_17820	COG4771	TonB-dependent receptor
AS4_17900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_17910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_17950	COG2252	PERMEase
AS4_17960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS4_17980	COG3038	cytochrome b561
AS4_18010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AS4_18030	COG0527	aspartate kinase activity
AS4_18070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS4_18120	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AS4_18130	COG1522	sequence-specific DNA binding
AS4_18140	COG1335	isochorismatase
AS4_18170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AS4_18180	COG4783	chaperone-mediated protein folding
AS4_18210	COG0667	Aldo Keto reductase
AS4_18230	COG1765	OsmC-like protein
AS4_18250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS4_18260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS4_18280	COG1045	serine acetyltransferase
AS4_18300	COG0542	response to heat
AS4_18360	COG0540	Belongs to the ATCase OTCase family
AS4_18420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_18440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS4_18450	COG0583	DNA-binding transcription factor activity
AS4_18530	COG0693	protein deglycase activity
AS4_18570	COG1802	Transcriptional regulator
AS4_18640	COG0204	Acyl-transferase
AS4_18680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS4_18700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS4_18720	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS4_18760	COG0477	Major facilitator Superfamily
AS4_18770	COG0729	surface antigen
AS4_18790	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_18820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS4_18830	COG4783	chaperone-mediated protein folding
AS4_18860	COG1610	YqeY-like protein
AS4_18870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AS4_18920	COG0436	Aminotransferase
AS4_18930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS4_18940	COG0386	Belongs to the glutathione peroxidase family
AS4_18950	COG1917	Cupin 2, conserved barrel domain protein
AS4_18950	COG2207	Transcriptional regulator
AS4_18980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_19010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AS4_19060	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AS4_19120	COG0012	GTP binding
AS4_19130	COG2011	ABC-type metal ion transport system permease component
AS4_19140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS4_19150	COG1464	Belongs to the NlpA lipoprotein family
AS4_19160	COG1464	Belongs to the NlpA lipoprotein family
AS4_19300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS4_19320	COG0786	glutamate:sodium symporter activity
AS4_19370	COG2707	UPF0756 membrane protein
AS4_19380	COG1959	2 iron, 2 sulfur cluster binding
AS4_19450	COG0802	atpase or kinase
AS4_19460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AS4_19480	COG1923	regulation of RNA biosynthetic process
AS4_19490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS4_19510	COG3178	'Phosphotransferase
AS4_19520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS4_19540	COG1192	Involved in chromosome partitioning
AS4_19550	COG1475	DNA binding
AS4_19560	COG0811	peptide transport
AS4_19580	COG1132	(ABC) transporter
AS4_19590	COG1663	tetraacyldisaccharide 4'-kinase activity
AS4_19630	COG0084	hydrolase, TatD family'
AS4_19680	COG3156	type II secretion system protein K
AS4_19700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS4_19720	COG0590	tRNA wobble adenosine to inosine editing
AS4_19760	COG0776	regulation of translation
AS4_19800	COG3121	Chaperone
AS4_19810	COG3539	Fimbrial protein
AS4_19850	COG0284	orotidine-5'-phosphate decarboxylase activity
AS4_19860	COG2431	L-lysine efflux transmembrane transporter activity
AS4_19900	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AS4_19910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS4_19920	COG0569	domain protein
AS4_19950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS4_19960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS4_20010	COG3706	GGDEF domain
AS4_20040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AS4_20050	COG0542	response to heat
AS4_20110	COG0583	DNA-binding transcription factor activity
AS4_20120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS4_20140	COG0583	DNA-binding transcription factor activity
AS4_20150	COG1960	acyl-CoA dehydrogenase activity
AS4_20160	COG2814	Major facilitator Superfamily
AS4_20230	COG0372	Belongs to the citrate synthase family
AS4_20260	COG0069	glutamate synthase activity
AS4_20290	COG2850	peptidyl-arginine hydroxylation
AS4_20320	COG0424	maF-like protein
AS4_20340	COG0126	phosphoglycerate kinase activity
AS4_20400	COG3196	Protein conserved in bacteria
AS4_20460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AS4_20480	COG0702	epimerase
AS4_20490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS4_20570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS4_20630	COG0316	Belongs to the HesB IscA family
AS4_20640	COG0822	iron-sulfur transferase activity
AS4_20660	COG1959	2 iron, 2 sulfur cluster binding
AS4_20690	COG0776	regulation of translation
AS4_20710	COG2207	Transcriptional regulator
AS4_20720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_20780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AS4_20860	COG1335	isochorismatase
AS4_20940	COG1271	oxidase subunit
AS4_20950	COG1294	oxidase, subunit
AS4_20960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS4_20980	COG2076	Multidrug Resistance protein
AS4_21000	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AS4_21090	COG0583	DNA-binding transcription factor activity
AS4_21210	COG2814	Major facilitator Superfamily
AS4_21230	COG0583	DNA-binding transcription factor activity
AS4_21240	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_21280	COG0697	spore germination
AS4_21290	COG0436	Aminotransferase
AS4_21310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS4_21350	COG0488	(ABC) transporter
AS4_21380	COG0596	Alpha beta hydrolase
AS4_21390	COG3135	benzoate transporter
AS4_21440	COG2814	Major facilitator Superfamily
AS4_21450	COG1346	cytolysis
AS4_21460	COG1380	Effector of murein hydrolase LrgA
AS4_21470	COG0583	DNA-binding transcription factor activity
AS4_21480	COG4628	conserved protein (DUF2132)
AS4_21500	COG1309	transcriptional regulator
AS4_21540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_21550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_21570	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_21580	COG0583	DNA-binding transcription factor activity
AS4_21600	COG0626	cystathionine gamma-synthase activity
AS4_21610	COG1024	Enoyl-CoA hydratase
AS4_21620	COG1960	acyl-CoA dehydrogenase activity
AS4_21690	COG0183	Belongs to the thiolase family
AS4_21730	COG1773	rubredoxin
AS4_21750	COG1522	sequence-specific DNA binding
AS4_21760	COG0583	DNA-binding transcription factor activity
AS4_21770	COG2814	Major facilitator Superfamily
AS4_21800	COG3119	arylsulfatase activity
AS4_21810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AS4_21830	COG4774	siderophore transport
AS4_21850	COG1846	Transcriptional regulator
AS4_21860	COG1309	transcriptional regulator
AS4_21910	COG1024	Enoyl-CoA hydratase
AS4_21920	COG1960	acyl-CoA dehydrogenase activity
AS4_21930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS4_21960	COG0583	DNA-binding transcription factor activity
AS4_21990	COG3501	Rhs element vgr protein
AS4_22000	COG1944	ATP diphosphatase activity
AS4_22030	COG2304	oxidoreductase activity
AS4_22110	COG1358	cellular component organization or biogenesis
AS4_22180	COG4245	von Willebrand factor, type A
AS4_22220	COG2072	flavoprotein involved in K transport
AS4_22270	COG1012	belongs to the aldehyde dehydrogenase family
AS4_22290	COG0583	DNA-binding transcription factor activity
AS4_22300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_22310	COG4266	Belongs to the allantoicase family
AS4_22320	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AS4_22340	COG2351	hydroxyisourate hydrolase activity
AS4_22400	COG0804	urea catabolic process
AS4_22460	COG0830	nickel cation binding
AS4_22480	COG0589	response to stress
AS4_22590	COG1960	acyl-CoA dehydrogenase activity
AS4_22600	COG1960	acyl-CoA dehydrogenase activity
AS4_22650	COG0509	glycine decarboxylation via glycine cleavage system
AS4_22850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS4_22920	COG0640	Transcriptional regulator
AS4_22960	COG3122	Protein conserved in bacteria
AS4_22990	COG0588	phosphoglycerate mutase activity
AS4_23000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AS4_23030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS4_23070	COG2223	nitrite transmembrane transporter activity
AS4_23130	COG1233	COG1233 Phytoene dehydrogenase and related
AS4_23140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS4_23180	COG1733	regulation of RNA biosynthetic process
AS4_23200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS4_23210	COG2267	carboxylic ester hydrolase activity
AS4_23220	COG2453	phosphatase
AS4_23220	COG0671	phosphoesterase, PA-phosphatase related
AS4_23250	COG4589	Belongs to the CDS family
AS4_23280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS4_23290	COG2937	Belongs to the GPAT DAPAT family
AS4_23300	COG0596	Alpha beta hydrolase
AS4_23300	COG2226	methyltransferase
AS4_23300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS4_23310	COG1309	transcriptional regulator
AS4_23370	COG0667	Aldo Keto reductase
AS4_23380	COG0583	DNA-binding transcription factor activity
AS4_23420	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_23480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS4_23490	COG0772	Belongs to the SEDS family
AS4_23510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AS4_23530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AS4_23560	COG1027	Aspartate ammonia-lyase
AS4_23600	COG1902	pentaerythritol trinitrate reductase activity
AS4_23600	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_23620	COG2267	carboxylic ester hydrolase activity
AS4_23640	COG2814	Major facilitator Superfamily
AS4_23650	COG0583	DNA-binding transcription factor activity
AS4_23670	COG4638	Rieske (2fe-2S)
AS4_23680	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AS4_23690	COG0633	Ferredoxin
AS4_23690	COG0543	2 iron, 2 sulfur cluster binding
AS4_23700	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_23710	COG3135	benzoate transporter
AS4_23760	COG0477	Major facilitator Superfamily
AS4_23790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS4_23810	COG1027	Aspartate ammonia-lyase
AS4_23840	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AS4_23840	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AS4_23840	COG0506	proline dehydrogenase activity
AS4_23950	COG1570	exodeoxyribonuclease VII activity
AS4_23970	COG0308	aminopeptidase N
AS4_24010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS4_24030	COG1846	Transcriptional regulator
AS4_24100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_24120	COG0511	ligase activity, forming carbon-carbon bonds
AS4_24130	COG0439	Biotin carboxylase
AS4_24150	COG3706	GGDEF domain
AS4_24170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS4_24190	COG1477	protein flavinylation
AS4_24210	COG0730	response to heat
AS4_24220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS4_24280	COG1322	Protein conserved in bacteria
AS4_24290	COG1011	Hydrolase
AS4_24300	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AS4_24310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS4_24320	COG2137	regulation of response to DNA damage stimulus
AS4_24340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_24360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_24380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS4_24410	COG0575	Belongs to the CDS family
AS4_24420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS4_24430	COG0233	cytoplasmic translational termination
AS4_24460	COG3852	Histidine kinase
AS4_24470	COG2204	response regulator
AS4_24490	COG3753	Protein conserved in bacteria
AS4_24520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_24530	COG4773	Receptor
AS4_24580	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AS4_24590	COG1132	(ABC) transporter
AS4_24640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS4_24690	COG1294	oxidase, subunit
AS4_24810	COG0659	secondary active sulfate transmembrane transporter activity
AS4_24830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS4_24880	COG0583	DNA-binding transcription factor activity
AS4_24890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS4_24920	COG3135	benzoate transporter
AS4_24930	COG0024	Methionine aminopeptidase
AS4_24980	COG1253	flavin adenine dinucleotide binding
AS4_25020	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS4_25060	COG0552	protein localization to endoplasmic reticulum
AS4_25070	COG0612	Peptidase, M16
AS4_25130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS4_25130	COG0517	IMP dehydrogenase activity
AS4_25140	COG0133	tryptophan synthase activity
AS4_25160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS4_25200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS4_25260	COG0537	adenosine 5'-monophosphoramidase activity
AS4_25340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS4_25350	COG1454	alcohol dehydrogenase
AS4_25370	COG0824	Thioesterase
AS4_25390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS4_25470	COG0183	Belongs to the thiolase family
AS4_25490	COG1454	alcohol dehydrogenase
AS4_25530	COG3284	Transcriptional regulator
AS4_25580	COG0583	DNA-binding transcription factor activity
AS4_25630	COG1309	transcriptional regulator
AS4_25640	COG0519	Catalyzes the synthesis of GMP from XMP
AS4_25640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS4_25650	COG3042	response to heat
AS4_25710	COG0789	Transcriptional regulator
AS4_25710	COG4978	Transcriptional regulator
AS4_25790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AS4_25800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AS4_25830	COG1280	lysine exporter protein (LysE YggA)
AS4_25880	COG1254	Belongs to the acylphosphatase family
AS4_25890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AS4_25890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AS4_25940	COG1286	toxin biosynthetic process
AS4_25950	COG0167	dihydroorotate dehydrogenase activity
AS4_26000	COG0778	Nitroreductase
AS4_26020	COG0513	Belongs to the DEAD box helicase family
AS4_26030	COG1278	Cold shock
AS4_26060	COG2363	Small membrane protein
AS4_26120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AS4_26130	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS4_26150	COG0625	glutathione transferase activity
AS4_26160	COG0659	secondary active sulfate transmembrane transporter activity
AS4_26180	COG4585	Histidine kinase
AS4_26200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS4_26210	COG1960	acyl-CoA dehydrogenase activity
AS4_26250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_26260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_26270	COG3781	membrane
AS4_26280	COG2890	protein-(glutamine-N5) methyltransferase activity
AS4_26290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS4_26320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_26330	COG4682	membrane
AS4_26410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS4_26420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS4_26430	COG1845	cytochrome c oxidase, subunit III
AS4_26440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS4_26490	COG0360	Binds together with S18 to 16S ribosomal RNA
AS4_26500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS4_26520	COG0305	Participates in initiation and elongation during chromosome replication
AS4_26540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS4_26570	COG1305	Transglutaminase-like
AS4_26590	COG2308	Evidence 4 Homologs of previously reported genes of
AS4_26670	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AS4_26680	COG0138	bifunctional purine biosynthesis protein purh
AS4_26690	COG0151	Belongs to the GarS family
AS4_26710	COG1464	Belongs to the NlpA lipoprotein family
AS4_26720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS4_26730	COG2011	ABC-type metal ion transport system permease component
AS4_26920	COG3022	response to hydroperoxide
AS4_26940	COG4650	regulator
AS4_26950	COG1234	tRNA 3'-trailer cleavage
AS4_27000	COG1690	Belongs to the RtcB family
AS4_27040	COG0430	RNA-3'-phosphate cyclase activity
AS4_27080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS4_27100	COG0693	protein deglycase activity
AS4_27120	COG1960	acyl-CoA dehydrogenase activity
AS4_27130	COG0616	signal peptide processing
AS4_27140	COG1301	dicarboxylic acid transport
AS4_27150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS4_27170	COG0573	inorganic phosphate transmembrane transporter activity
AS4_27270	COG1137	ATPase activity
AS4_27280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AS4_27300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AS4_27310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS4_27310	COG0517	IMP dehydrogenase activity
AS4_27420	COG1671	Belongs to the UPF0178 family
AS4_27490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_27520	COG1301	dicarboxylic acid transport
AS4_27540	COG0463	Glycosyl transferase, family 2
AS4_27600	COG0047	phosphoribosylformylglycinamidine synthase activity
AS4_27600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS4_27660	COG2255	four-way junction helicase activity
AS4_27670	COG4771	TonB-dependent receptor
AS4_27680	COG2031	fatty acid transporter
AS4_27730	COG0431	NADPH-dependent FMN reductase
AS4_27740	COG0798	PFAM Bile acid sodium symporter
AS4_27760	COG0640	Transcriptional regulator
AS4_27880	COG3299	homolog of phage Mu protein gp47
AS4_27970	COG4386	tail sheath protein
AS4_28220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS4_28300	COG0824	Thioesterase
AS4_28360	COG0823	Involved in the tonB-independent uptake of proteins
AS4_28410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS4_28510	COG0582	viral genome integration into host DNA
AS4_28540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_28560	COG3772	lysozyme
AS4_29040	COG0512	Glutamine amidotransferase of anthranilate synthase
AS4_29050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS4_29120	COG4302	ethanolamine ammonia-lyase activity
AS4_29130	COG4303	Ethanolamine ammonia lyase large subunit
AS4_29140	COG0531	amino acid
AS4_29180	COG3739	integral membrane protein
AS4_29210	COG1741	Belongs to the pirin family
AS4_29220	COG0235	Class ii aldolase
AS4_29240	COG2233	PERMEase
AS4_29250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_29260	COG0251	oxidation-reduction process
AS4_29270	COG1335	isochorismatase
AS4_29280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_29300	COG0596	Alpha beta hydrolase
AS4_29390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_29410	COG0864	Transcriptional regulator
AS4_29430	COG0439	Biotin carboxylase
AS4_29460	COG0583	DNA-binding transcription factor activity
AS4_29470	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AS4_29490	COG1724	mRNA binding
AS4_29500	COG1598	PFAM Uncharacterised protein family UPF0150
AS4_29510	COG4774	siderophore transport
AS4_29570	COG0583	DNA-binding transcription factor activity
AS4_29600	COG0251	oxidation-reduction process
AS4_29610	COG1012	belongs to the aldehyde dehydrogenase family
AS4_29630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS4_29680	COG1629	transport
AS4_29840	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AS4_29890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS4_29930	COG2267	carboxylic ester hydrolase activity
AS4_29980	COG1012	belongs to the aldehyde dehydrogenase family
AS4_29990	COG0028	Belongs to the TPP enzyme family
AS4_30050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS4_30090	COG1113	amino acid transport
AS4_30100	COG1414	Transcriptional regulator
AS4_30110	COG2610	gluconate transmembrane transporter activity
AS4_30120	COG1454	alcohol dehydrogenase
AS4_30170	COG3188	usher protein
AS4_30270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_30340	COG2855	membrane
AS4_30380	COG3246	L-lysine catabolic process to acetate
AS4_30390	COG2175	clavaminate synthase activity
AS4_30440	COG4251	negative regulation of phosphorylation
AS4_30440	COG2203	Gaf domain
AS4_30440	COG5001	Diguanylate cyclase
AS4_30440	COG3706	GGDEF domain
AS4_30450	COG0659	secondary active sulfate transmembrane transporter activity
AS4_30460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AS4_30470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS4_30510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AS4_30520	COG1840	ABC-type Fe3 transport system, periplasmic component
AS4_30580	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_30580	COG1902	pentaerythritol trinitrate reductase activity
AS4_30600	COG0277	FAD linked oxidase domain protein
AS4_30620	COG2186	Transcriptional regulator
AS4_30640	COG0697	spore germination
AS4_30650	COG0583	DNA-binding transcription factor activity
AS4_30720	COG0477	Major facilitator Superfamily
AS4_30750	COG1960	acyl-CoA dehydrogenase activity
AS4_30840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AS4_30860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS4_30880	COG0280	phosphate acetyltransferase
AS4_30880	COG0281	malic enzyme
AS4_30900	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AS4_30930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS4_30950	COG2351	hydroxyisourate hydrolase activity
AS4_30970	COG1686	Belongs to the peptidase S11 family
AS4_30980	COG1252	NADH dehydrogenase
AS4_30990	COG1047	Peptidyl-prolyl cis-trans
AS4_31000	COG0415	Belongs to the DNA photolyase family
AS4_31050	COG0667	Aldo Keto reductase
AS4_31070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AS4_31080	COG1381	Involved in DNA repair and RecF pathway recombination
AS4_31100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS4_31110	COG0571	ribonuclease III activity
AS4_31180	COG4221	oxidoreductase activity
AS4_31190	COG0625	glutathione transferase activity
AS4_31210	COG0242	peptide deformylase activity
AS4_31250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS4_31290	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AS4_31320	COG2207	Transcriptional regulator
AS4_31390	COG2207	Transcriptional regulator
AS4_31420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS4_31500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS4_31520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AS4_31540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AS4_31550	COG4208	sulfate ABC transporter
AS4_31560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AS4_31570	COG0583	DNA-binding transcription factor activity
AS4_31610	COG0602	queuosine metabolic process
AS4_31620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AS4_31650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS4_31680	COG0625	glutathione transferase activity
AS4_31710	COG2353	YceI-like domain
AS4_31720	COG1051	belongs to the nudix hydrolase family
AS4_31720	COG1056	cytidyltransferase-related domain
AS4_31730	COG1024	Enoyl-CoA hydratase
AS4_31740	COG0778	Nitroreductase
AS4_31750	COG3323	Protein of unknown function (DUF1653)
AS4_31750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS4_31810	COG1280	lysine exporter protein (LysE YggA)
AS4_31820	COG1522	sequence-specific DNA binding
AS4_31870	COG2234	aminopeptidase activity
AS4_31880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AS4_31890	COG3384	dioxygenase
AS4_31920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS4_31940	COG2878	Part of a membrane complex involved in electron transport
AS4_31950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS4_32010	COG0768	penicillin binding
AS4_32020	COG0742	ribosomal rna small subunit methyltransferase
AS4_32060	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_32070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS4_32090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS4_32120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS4_32130	COG1053	succinate dehydrogenase
AS4_32140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AS4_32150	COG2009	succinate dehydrogenase
AS4_32170	COG3104	oligopeptide transport
AS4_32210	COG2072	flavoprotein involved in K transport
AS4_32220	COG0300	oxidoreductase activity
AS4_32300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS4_32310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS4_32330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AS4_32370	COG0505	Belongs to the CarA family
AS4_32380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AS4_32410	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AS4_32420	COG0110	maltose O-acetyltransferase activity
AS4_32430	COG1113	amino acid transport
AS4_32450	COG0625	glutathione transferase activity
AS4_32490	COG1024	Enoyl-CoA hydratase
AS4_32550	COG2321	neutral zinc metallopeptidase
AS4_32560	COG2354	Protein conserved in bacteria
AS4_32620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS4_32630	COG1773	rubredoxin
AS4_32640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_32660	COG0583	DNA-binding transcription factor activity
AS4_32710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AS4_32720	COG4181	ATPase activity
AS4_32760	COG0560	Phosphoserine phosphatase
AS4_32780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS4_32800	COG1530	ribonuclease E activity
AS4_32810	COG0424	maF-like protein
AS4_32820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AS4_32830	COG1792	Involved in formation and maintenance of cell shape
AS4_32840	COG1077	Cell shape determining protein MreB Mrl
AS4_32850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS4_32870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS4_32900	COG2318	DinB family
AS4_32960	COG0583	DNA-binding transcription factor activity
AS4_33030	COG0523	cobalamin synthesis protein
AS4_33050	COG1469	GTP cyclohydrolase I activity
AS4_33070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS4_33080	COG0789	Transcriptional regulator
AS4_33090	COG1902	pentaerythritol trinitrate reductase activity
AS4_33090	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_33110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_33180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_33200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_33210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_33220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_33250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS4_33280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_33320	COG1132	(ABC) transporter
AS4_33330	COG1132	(ABC) transporter
AS4_33370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS4_33380	COG0601	transmembrane transport
AS4_33430	COG4774	siderophore transport
AS4_33440	COG4607	ABC-type enterochelin transport system periplasmic component
AS4_33450	COG4604	ABC transporter, ATP-binding protein
AS4_33460	COG4605	iron ion homeostasis
AS4_33470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS4_33520	COG1063	alcohol dehydrogenase
AS4_33540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS4_33550	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS4_33560	COG0022	dehydrogenase e1 component
AS4_33570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS4_33580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS4_33610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS4_33620	COG1309	transcriptional regulator
AS4_33660	COG1309	transcriptional regulator
AS4_33670	COG2814	Major facilitator Superfamily
AS4_33710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_33730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_33740	COG0235	Class ii aldolase
AS4_33750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS4_33770	COG0028	Belongs to the TPP enzyme family
AS4_33800	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_33830	COG2271	Major facilitator Superfamily
AS4_33840	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_33960	COG1733	regulation of RNA biosynthetic process
AS4_33990	COG3209	COG3209 Rhs family protein
AS4_34000	COG3501	Rhs element vgr protein
AS4_34010	COG0789	Transcriptional regulator
AS4_34030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_34040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_34090	COG1595	DNA-templated transcription, initiation
AS4_34120	COG0583	DNA-binding transcription factor activity
AS4_34130	COG2610	gluconate transmembrane transporter activity
AS4_34150	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_34160	COG0583	DNA-binding transcription factor activity
AS4_34260	COG3008	intermembrane lipid transfer
AS4_34260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AS4_34270	COG2995	paraquat-inducible protein a
AS4_34300	COG0477	Major facilitator Superfamily
AS4_34330	COG2274	protein secretion by the type I secretion system
AS4_34370	COG0583	DNA-binding transcription factor activity
AS4_34380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS4_34390	COG1012	belongs to the aldehyde dehydrogenase family
AS4_34410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS4_34420	COG1012	belongs to the aldehyde dehydrogenase family
AS4_34430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_34440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_34450	COG2267	carboxylic ester hydrolase activity
AS4_34530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_34550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_34560	COG1414	Transcriptional regulator
AS4_34580	COG2819	hydrolase of the alpha beta superfamily
AS4_34590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS4_34610	COG2985	domain, Protein
AS4_34650	COG3327	negative regulation of DNA-templated transcription, initiation
AS4_34660	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AS4_34670	COG0183	Belongs to the thiolase family
AS4_34680	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_34690	COG1024	Enoyl-CoA hydratase
AS4_34700	COG1024	Enoyl-CoA hydratase
AS4_34710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_34720	COG2151	metal-sulfur cluster biosynthetic enzyme
AS4_34730	COG3396	Phenylacetate-CoA oxygenase
AS4_34740	COG3460	Phenylacetate-CoA oxygenase
AS4_34750	COG3396	Phenylacetate-CoA oxygenase
AS4_34760	COG1012	belongs to the aldehyde dehydrogenase family
AS4_34760	COG2030	dehydratase
AS4_34770	COG0477	Major facilitator Superfamily
AS4_34870	COG3177	Filamentation induced by cAMP protein fic
AS4_34900	COG2271	Major facilitator Superfamily
AS4_34930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AS4_34940	COG0242	peptide deformylase activity
AS4_35020	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS4_35030	COG2268	Band 7 protein
AS4_35060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS4_35070	COG0523	cobalamin synthesis protein
AS4_35090	COG0204	Acyl-transferase
AS4_35120	COG1280	lysine exporter protein (LysE YggA)
AS4_35140	COG0531	amino acid
AS4_35140	COG1674	ftsk spoiiie
AS4_35150	COG0492	ferredoxin-NADP+ reductase activity
AS4_35160	COG0500	methyltransferase
AS4_35170	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AS4_35240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AS4_35260	COG0714	Associated with various cellular activities
AS4_35280	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AS4_35300	COG3831	ATPase activity
AS4_35310	COG3831	ATPase activity
AS4_35360	COG1113	amino acid transport
AS4_35420	COG0352	thiamine-phosphate diphosphorylase activity
AS4_35420	COG0351	phosphomethylpyrimidine kinase
AS4_35420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS4_35440	COG2207	Transcriptional regulator
AS4_35460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS4_35510	COG2132	Multicopper oxidase
AS4_35530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS4_35550	COG4269	membrane
AS4_35560	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AS4_35590	COG1968	undecaprenyl-diphosphatase activity
AS4_35600	COG1214	PFAM Peptidase M22, glycoprotease
AS4_35610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS4_35620	COG0494	nUDIX hydrolase
AS4_35720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS4_35740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS4_35800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_35810	COG0765	amino acid transport
AS4_35820	COG0765	amino acid transport
AS4_35830	COG1126	abc transporter atp-binding protein
AS4_35880	COG4716	Myosin-crossreactive antigen
AS4_35910	COG2226	methyltransferase
AS4_35970	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AS4_35980	COG2081	HI0933 family
AS4_36010	COG0668	transmembrane transport
AS4_36040	COG2814	Major facilitator Superfamily
AS4_36050	COG1289	transmembrane transporter activity
AS4_36110	COG2832	Protein of unknown function (DUF454)
AS4_36180	COG0840	transmembrane signaling receptor activity
AS4_36230	COG0442	prolyl-tRNA aminoacylation
AS4_36340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS4_36360	COG0489	protein tyrosine kinase activity
AS4_36430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_36430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_36470	COG2199	diguanylate cyclase activity
AS4_36500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS4_36530	COG0450	alkyl hydroperoxide reductase
AS4_36540	COG1652	LysM domain
AS4_36550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS4_36590	COG1399	metal-binding, possibly nucleic acid-binding protein
AS4_36600	COG3101	peptidyl-lysine hydroxylation
AS4_36610	COG0009	L-threonylcarbamoyladenylate synthase
AS4_36650	COG0285	dihydrofolate synthase activity
AS4_36730	COG3152	Membrane
AS4_36750	COG0183	Belongs to the thiolase family
AS4_36770	COG0454	-acetyltransferase
AS4_36780	COG2207	Transcriptional regulator
AS4_36790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS4_36820	COG0494	nUDIX hydrolase
AS4_36850	COG3422	double-strand break repair
AS4_36880	COG4106	trans-aconitate 2-methyltransferase activity
AS4_36910	COG2267	carboxylic ester hydrolase activity
AS4_36930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS4_36950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS4_36970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AS4_36990	COG1196	nuclear chromosome segregation
AS4_37010	COG0730	response to heat
AS4_37070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS4_37100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS4_37200	COG3501	Rhs element vgr protein
AS4_37300	COG1272	protein, Hemolysin III
AS4_37310	COG0477	Major facilitator Superfamily
AS4_37330	COG0564	pseudouridine synthase activity
AS4_37350	COG1024	Enoyl-CoA hydratase
AS4_37360	COG1960	acyl-CoA dehydrogenase activity
AS4_37370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS4_37380	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_37410	COG1309	transcriptional regulator
AS4_37450	COG1960	acyl-CoA dehydrogenase activity
AS4_37460	COG1960	acyl-CoA dehydrogenase activity
AS4_37470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS4_37520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS4_37530	COG1846	Transcriptional regulator
AS4_37540	COG1764	response to oxidative stress
AS4_37600	COG3384	dioxygenase
AS4_37620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_37670	COG0133	tryptophan synthase activity
AS4_37690	COG4206	TonB-dependent receptor
AS4_37700	COG2096	Adenosyltransferase
AS4_37740	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AS4_37760	COG2315	Protein conserved in bacteria
AS4_37770	COG0745	RESPONSE REGULATOR receiver
AS4_37780	COG2205	protein histidine kinase activity
AS4_37800	COG3028	Belongs to the UPF0307 family
AS4_37810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS4_37820	COG1660	Displays ATPase and GTPase activities
AS4_37830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS4_37850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS4_37860	COG0617	tRNA 3'-terminal CCA addition
AS4_37880	COG3956	TIGRFAM MazG family protein
AS4_37910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS4_37950	COG0784	Response regulator, receiver
AS4_37950	COG5002	protein histidine kinase activity
AS4_37950	COG2205	protein histidine kinase activity
AS4_37960	COG1024	Enoyl-CoA hydratase
AS4_37970	COG2084	Dehydrogenase
AS4_37980	COG3622	Belongs to the hyi family
AS4_38000	COG0004	ammonium transporteR
AS4_38070	COG1426	Protein conserved in bacteria
AS4_38120	COG0671	phosphoesterase, PA-phosphatase related
AS4_38160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AS4_38170	COG0440	acetolactate synthase activity
AS4_38180	COG0028	Belongs to the TPP enzyme family
AS4_38230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_38240	COG0577	efflux transmembrane transporter activity
AS4_38240	COG1136	(ABC) transporter
AS4_38250	COG1538	Outer membrane efflux protein
AS4_38320	COG3501	Rhs element vgr protein
AS4_38350	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AS4_38360	COG1162	GTPase activity
AS4_38380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AS4_38450	COG3783	Cytochrome b(562)
AS4_38460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS4_38470	COG2003	Belongs to the UPF0758 family
AS4_38480	COG3781	membrane
AS4_38550	COG1946	Acyl-CoA thioesterase
AS4_38580	COG1295	ribonuclease BN
AS4_38600	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS4_38650	COG2814	Major facilitator Superfamily
AS4_38660	COG1733	regulation of RNA biosynthetic process
AS4_38670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_38680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_38690	COG1126	abc transporter atp-binding protein
AS4_38700	COG0765	amino acid transport
AS4_38710	COG0765	amino acid transport
AS4_38740	COG0557	exoribonuclease II activity
AS4_38760	COG0339	signal peptide processing
AS4_38770	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AS4_38860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AS4_38880	COG1960	acyl-CoA dehydrogenase activity
AS4_38890	COG2072	flavoprotein involved in K transport
AS4_38900	COG0203	ribosomal protein L17
AS4_38910	COG0202	RNA polymerase activity
AS4_38920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AS4_38930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AS4_38950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AS4_38990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS4_39020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AS4_39040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AS4_39060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS4_39110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AS4_39120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS4_39150	COG0088	Forms part of the polypeptide exit tunnel
AS4_39160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS4_39170	COG0051	transcription antitermination factor activity, RNA binding
AS4_39200	COG0433	COG0433 Predicted ATPase
AS4_39210	COG1017	nitric oxide dioxygenase activity
AS4_39210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_39220	COG1959	2 iron, 2 sulfur cluster binding
AS4_39250	COG1301	dicarboxylic acid transport
AS4_39260	COG1946	Acyl-CoA thioesterase
AS4_39270	COG2937	Belongs to the GPAT DAPAT family
AS4_39300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS4_39320	COG1040	competence protein
AS4_39330	COG0494	nUDIX hydrolase
AS4_39350	COG0598	Magnesium transport protein CorA
AS4_39380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AS4_39390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AS4_39400	COG1127	ABC transporter
AS4_39440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AS4_39450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS4_39460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS4_39510	COG1960	acyl-CoA dehydrogenase activity
AS4_39530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS4_39550	COG0534	Mate efflux family protein
AS4_39570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS4_39580	COG0254	rRNA binding
AS4_39590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS4_39650	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AS4_39670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS4_39700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS4_39720	COG0644	oxidoreductase
AS4_39720	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AS4_39760	COG0425	Belongs to the sulfur carrier protein TusA family
AS4_39770	COG4535	Mg2 and Co2 transporter CorC
AS4_39780	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AS4_39790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_39790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_39840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS4_39880	COG0475	glutathione-regulated potassium exporter activity
AS4_39880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS4_39890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AS4_39910	COG0789	Transcriptional regulator
AS4_39920	COG2841	Protein conserved in bacteria
AS4_39930	COG0598	Magnesium transport protein CorA
AS4_39940	COG1185	polyribonucleotide nucleotidyltransferase activity
AS4_39970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS4_39980	COG1074	ATP-dependent DNA helicase activity
AS4_39990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AS4_40030	COG2271	Major facilitator Superfamily
AS4_40040	COG1335	isochorismatase
AS4_40050	COG3473	Maleate cis-trans isomerase
AS4_40060	COG0596	Alpha beta hydrolase
AS4_40070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_40080	COG2309	aminopeptidase activity
AS4_40090	COG1846	Transcriptional regulator
AS4_40140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS4_40170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS4_40220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS4_40220	COG2111	Na H antiporter
AS4_40230	COG1006	Multisubunit Na H antiporter MnhC subunit
AS4_40240	COG0651	ATP synthesis coupled electron transport
AS4_40260	COG2212	antiporter activity
AS4_40280	COG0307	riboflavin synthase, alpha
AS4_40300	COG1733	regulation of RNA biosynthetic process
AS4_40310	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS4_40320	COG0493	'glutamate synthase
AS4_40330	COG0069	glutamate synthase activity
AS4_40330	COG0070	glutamate synthase
AS4_40330	COG0067	glutamate synthase
AS4_40440	COG2226	methyltransferase
AS4_40450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS4_40460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS4_40470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS4_40490	COG3116	cell division
AS4_40520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AS4_40560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS4_40650	COG4221	oxidoreductase activity
AS4_40710	COG0789	Transcriptional regulator
AS4_40740	COG0745	RESPONSE REGULATOR receiver
AS4_40750	COG2205	protein histidine kinase activity
AS4_40760	COG0427	acetyl-CoA hydrolase
AS4_40830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS4_40890	COG0697	spore germination
AS4_40920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS4_40950	COG0488	(ABC) transporter
AS4_40990	COG0704	Plays a role in the regulation of phosphate uptake
AS4_41040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AS4_41050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS4_41060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS4_41080	COG0772	Belongs to the SEDS family
AS4_41100	COG0586	Pfam SNARE associated Golgi protein
AS4_41130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS4_41130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS4_41150	COG0004	ammonium transporteR
AS4_41160	COG0347	Belongs to the P(II) protein family
AS4_41180	COG0606	chelatase, subunit chli
AS4_41200	COG3153	acetyltransferase
AS4_41250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AS4_41280	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_41310	COG0477	Major facilitator Superfamily
AS4_41330	COG2860	membrane
AS4_41340	COG3012	SEC-C Motif Domain Protein
AS4_41350	COG1253	flavin adenine dinucleotide binding
AS4_41410	COG3706	GGDEF domain
AS4_41440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS4_41460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS4_41470	COG3162	membrane
AS4_41480	COG2205	protein histidine kinase activity
AS4_41480	COG0784	Response regulator, receiver
AS4_41520	COG2133	pyrroloquinoline quinone binding
AS4_41540	COG1309	transcriptional regulator
AS4_41610	COG1652	LysM domain
AS4_41620	COG0758	DNA mediated transformation
AS4_41630	COG0009	L-threonylcarbamoyladenylate synthase
AS4_41640	COG0697	spore germination
AS4_41650	COG1309	transcriptional regulator
AS4_41700	COG0386	Belongs to the glutathione peroxidase family
AS4_41770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS4_41790	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS4_41850	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AS4_41870	COG1121	(ABC) transporter
AS4_41880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS4_41900	COG1280	lysine exporter protein (LysE YggA)
AS4_41910	COG2837	iron assimilation
AS4_41950	COG3501	Rhs element vgr protein
AS4_41960	COG0281	malic enzyme
AS4_42020	COG0745	RESPONSE REGULATOR receiver
AS4_42030	COG2205	protein histidine kinase activity
AS4_42040	COG4452	Inner membrane protein CreD
AS4_42090	COG2814	Major facilitator Superfamily
AS4_42110	COG0431	NADPH-dependent FMN reductase
AS4_42150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS4_42170	COG0668	transmembrane transport
AS4_42180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS4_42190	COG1519	Transferase
AS4_42200	COG1902	pentaerythritol trinitrate reductase activity
AS4_42260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS4_42260	COG0519	Catalyzes the synthesis of GMP from XMP
AS4_42270	COG2259	Doxx family
AS4_42280	COG0586	Pfam SNARE associated Golgi protein
AS4_42300	COG1192	Involved in chromosome partitioning
AS4_42320	COG0271	Belongs to the BolA IbaG family
AS4_42370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS4_42400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS4_42430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS4_42440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS4_42470	COG0110	maltose O-acetyltransferase activity
AS4_42480	COG1215	transferase activity, transferring glycosyl groups
AS4_42550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS4_42620	COG1596	polysaccharide export
AS4_42670	COG0728	peptidoglycan biosynthetic process
AS4_42680	COG3023	N-Acetylmuramoyl-L-alanine amidase
AS4_42740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AS4_42760	COG2207	Transcriptional regulator
AS4_42810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AS4_42820	COG0546	phosphoglycolate phosphatase activity
AS4_42840	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_42890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS4_42890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AS4_42900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_42910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_42920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_42930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_42940	COG1116	anion transmembrane transporter activity
AS4_42950	COG1309	transcriptional regulator
AS4_43200	COG0737	Belongs to the 5'-nucleotidase family
AS4_43210	COG2175	clavaminate synthase activity
AS4_43220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_43230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AS4_43240	COG4521	taurine ABC transporter
AS4_43310	COG0443	Heat shock 70 kDa protein
AS4_43380	COG2951	lytic endotransglycosylase activity
AS4_43400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS4_43450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS4_43480	COG2388	GCN5-related N-acetyl-transferase
AS4_43490	COG2814	Major facilitator Superfamily
AS4_43530	COG0861	Integral membrane protein TerC family
AS4_43550	COG0402	S-adenosylhomocysteine deaminase activity
AS4_43570	COG2261	transglycosylase associated protein
AS4_43580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AS4_43590	COG1230	cation diffusion facilitator family transporter
AS4_43640	COG0706	membrane insertase activity
AS4_43650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AS4_43660	COG0594	ribonuclease P activity
AS4_43670	COG0230	Belongs to the bacterial ribosomal protein bL34 family