locus-tag	class	description
AhaeAN4_00010	COG0592	DNA-directed DNA polymerase activity
AhaeAN4_00020	COG0187	DNA topoisomerase II activity
AhaeAN4_00025	COG0586	Pfam SNARE associated Golgi protein
AhaeAN4_00030	COG0488	(ABC) transporter
AhaeAN4_00055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AhaeAN4_00060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AhaeAN4_00100	COG3273	potassium ion transport
AhaeAN4_00100	COG0471	metal ion transport
AhaeAN4_00110	COG1012	belongs to the aldehyde dehydrogenase family
AhaeAN4_00115	COG3738	Protein conserved in bacteria
AhaeAN4_00125	COG0733	neurotransmitter:sodium symporter activity
AhaeAN4_00165	COG2233	PERMEase
AhaeAN4_00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhaeAN4_00195	COG0484	heat shock protein binding
AhaeAN4_00210	COG2814	Major facilitator Superfamily
AhaeAN4_00215	COG0656	L-ascorbic acid biosynthetic process
AhaeAN4_00220	COG0583	DNA-binding transcription factor activity
AhaeAN4_00235	COG1064	alcohol dehydrogenase
AhaeAN4_00240	COG2818	Glycosylase
AhaeAN4_00255	COG1194	a g-specific adenine glycosylase
AhaeAN4_00265	COG5487	UPF0391 membrane protein
AhaeAN4_00270	COG2983	Belongs to the UPF0260 family
AhaeAN4_00275	COG2133	pyrroloquinoline quinone binding
AhaeAN4_00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AhaeAN4_00295	COG1228	amidohydrolase
AhaeAN4_00300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AhaeAN4_00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AhaeAN4_00315	COG1335	isochorismatase
AhaeAN4_00320	COG1522	sequence-specific DNA binding
AhaeAN4_00365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AhaeAN4_00375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AhaeAN4_00380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AhaeAN4_00385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AhaeAN4_00405	COG3830	Belongs to the UPF0237 family
AhaeAN4_00405	COG0560	Phosphoserine phosphatase
AhaeAN4_00450	COG1278	Cold shock
AhaeAN4_00455	COG0583	DNA-binding transcription factor activity
AhaeAN4_00500	COG0436	Aminotransferase
AhaeAN4_00510	COG2733	membrane
AhaeAN4_00525	COG2918	glutathione biosynthetic process
AhaeAN4_00540	COG3150	esterase
AhaeAN4_00585	COG1247	-acetyltransferase
AhaeAN4_00615	COG0625	glutathione transferase activity
AhaeAN4_00635	COG1393	Belongs to the ArsC family
AhaeAN4_00640	COG0708	Exodeoxyribonuclease III
AhaeAN4_00685	COG2801	Transposase and inactivated derivatives
AhaeAN4_00700	COG0386	Belongs to the glutathione peroxidase family
AhaeAN4_00705	COG0189	ligase activity
AhaeAN4_00725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AhaeAN4_00760	COG0508	dehydrogenase complex catalyzes the overall conversion of
AhaeAN4_00770	COG2119	membrane
AhaeAN4_00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AhaeAN4_00790	COG0426	domain, Protein
AhaeAN4_00820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AhaeAN4_00850	COG1902	pentaerythritol trinitrate reductase activity
AhaeAN4_00855	COG1519	Transferase
AhaeAN4_00865	COG0668	transmembrane transport
AhaeAN4_00870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AhaeAN4_00900	COG3706	GGDEF domain
AhaeAN4_00935	COG0352	thiamine-phosphate diphosphorylase activity
AhaeAN4_00935	COG0351	phosphomethylpyrimidine kinase
AhaeAN4_00935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AhaeAN4_00945	COG2814	Major facilitator Superfamily
AhaeAN4_00970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AhaeAN4_00975	COG1012	belongs to the aldehyde dehydrogenase family
AhaeAN4_00985	COG1335	isochorismatase
AhaeAN4_00995	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AhaeAN4_01060	COG0582	viral genome integration into host DNA
AhaeAN4_01070	COG3158	transport of potassium into the cell
AhaeAN4_01085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AhaeAN4_01105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AhaeAN4_01125	COG0659	secondary active sulfate transmembrane transporter activity
AhaeAN4_01140	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_01145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AhaeAN4_01180	COG0427	acetyl-CoA hydrolase
AhaeAN4_01185	COG2205	protein histidine kinase activity
AhaeAN4_01190	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_01215	COG1028	Short-chain dehydrogenase reductase Sdr
AhaeAN4_01220	COG0583	DNA-binding transcription factor activity
AhaeAN4_01230	COG0789	Transcriptional regulator
AhaeAN4_01235	COG3320	Male sterility
AhaeAN4_01235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AhaeAN4_01245	COG4221	oxidoreductase activity
AhaeAN4_01250	COG2873	o-acetylhomoserine
AhaeAN4_01255	COG0488	(ABC) transporter
AhaeAN4_01325	COG0833	amino acid
AhaeAN4_01350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AhaeAN4_01370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AhaeAN4_01375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AhaeAN4_01380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AhaeAN4_01385	COG2226	methyltransferase
AhaeAN4_01435	COG0070	glutamate synthase
AhaeAN4_01435	COG0067	glutamate synthase
AhaeAN4_01435	COG0069	glutamate synthase activity
AhaeAN4_01440	COG0493	'glutamate synthase
AhaeAN4_01450	COG1704	LemA family
AhaeAN4_01455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AhaeAN4_01475	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_01505	COG3307	-O-antigen
AhaeAN4_01525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhaeAN4_01535	COG0194	GDP metabolic process
AhaeAN4_01540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AhaeAN4_01550	COG4969	Belongs to the N-Me-Phe pilin family
AhaeAN4_01635	COG0228	four-way junction DNA binding
AhaeAN4_01640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AhaeAN4_01650	COG0335	large ribosomal subunit rRNA binding
AhaeAN4_01660	COG5380	lipid catabolic process
AhaeAN4_01665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AhaeAN4_01705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AhaeAN4_01710	COG0277	FAD linked oxidase domain protein
AhaeAN4_01725	COG1484	DNA-dependent DNA replication
AhaeAN4_01730	COG2390	Transcriptional regulator
AhaeAN4_01730	COG4584	PFAM Integrase catalytic
AhaeAN4_01775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AhaeAN4_01780	COG2249	NAD(P)H dehydrogenase (quinone) activity
AhaeAN4_01795	COG1289	transmembrane transporter activity
AhaeAN4_01800	COG0628	permease
AhaeAN4_01805	COG1192	Involved in chromosome partitioning
AhaeAN4_01815	COG2226	methyltransferase
AhaeAN4_01850	COG1404	Belongs to the peptidase S8 family
AhaeAN4_01860	COG2072	flavoprotein involved in K transport
AhaeAN4_01920	COG0471	metal ion transport
AhaeAN4_01930	COG4372	Transposase
AhaeAN4_01940	COG2963	transposase activity
AhaeAN4_01955	COG1983	PspC domain protein
AhaeAN4_01965	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_02025	COG1127	ABC transporter
AhaeAN4_02030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AhaeAN4_02035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AhaeAN4_02040	COG2854	intermembrane phospholipid transfer
AhaeAN4_02055	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_02065	COG0598	Magnesium transport protein CorA
AhaeAN4_02080	COG1040	competence protein
AhaeAN4_02085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AhaeAN4_02100	COG2937	Belongs to the GPAT DAPAT family
AhaeAN4_02105	COG1946	Acyl-CoA thioesterase
AhaeAN4_02110	COG1301	dicarboxylic acid transport
AhaeAN4_02130	COG1959	2 iron, 2 sulfur cluster binding
AhaeAN4_02140	COG0433	COG0433 Predicted ATPase
AhaeAN4_02160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AhaeAN4_02180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AhaeAN4_02230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AhaeAN4_02310	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_02315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AhaeAN4_02340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AhaeAN4_02410	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AhaeAN4_02435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AhaeAN4_02460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AhaeAN4_02465	COG0534	Mate efflux family protein
AhaeAN4_02475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AhaeAN4_02490	COG0318	PFAM AMP-dependent synthetase and ligase
AhaeAN4_02495	COG1530	ribonuclease E activity
AhaeAN4_02505	COG0564	pseudouridine synthase activity
AhaeAN4_02525	COG0625	glutathione transferase activity
AhaeAN4_02560	COG0494	nUDIX hydrolase
AhaeAN4_02595	COG0473	3-isopropylmalate dehydrogenase activity
AhaeAN4_02645	COG1560	Kdo2-lipid A biosynthetic process
AhaeAN4_02660	COG2900	Belongs to the SlyX family
AhaeAN4_02670	COG1733	regulation of RNA biosynthetic process
AhaeAN4_02695	COG0210	DNA helicase
AhaeAN4_02715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AhaeAN4_02715	COG4651	solute:proton antiporter activity
AhaeAN4_02740	COG0788	formyltetrahydrofolate deformylase activity
AhaeAN4_02805	COG4773	Receptor
AhaeAN4_02820	COG1702	phosphate starvation-inducible protein PhoH
AhaeAN4_02830	COG0741	lytic transglycosylase activity
AhaeAN4_02830	COG0739	heme binding
AhaeAN4_02830	COG1196	nuclear chromosome segregation
AhaeAN4_02860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AhaeAN4_02865	COG1183	phosphatidylcholine synthase activity
AhaeAN4_02930	COG1607	acyl-coa hydrolase
AhaeAN4_02935	COG1956	GAF domain-containing protein
AhaeAN4_02950	COG1666	GTP binding
AhaeAN4_02985	COG3781	membrane
AhaeAN4_02995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AhaeAN4_03030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AhaeAN4_03040	COG1162	GTPase activity
AhaeAN4_03045	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AhaeAN4_03080	COG1538	Outer membrane efflux protein
AhaeAN4_03085	COG0577	efflux transmembrane transporter activity
AhaeAN4_03085	COG1136	(ABC) transporter
AhaeAN4_03090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhaeAN4_03095	COG1466	dna polymerase III delta subunit
AhaeAN4_03115	COG0028	Belongs to the TPP enzyme family
AhaeAN4_03120	COG0440	acetolactate synthase activity
AhaeAN4_03125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AhaeAN4_03175	COG4372	Transposase
AhaeAN4_03185	COG2963	transposase activity
AhaeAN4_03220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AhaeAN4_03235	COG0084	hydrolase, TatD family'
AhaeAN4_03250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AhaeAN4_03260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AhaeAN4_03310	COG2963	transposase activity
AhaeAN4_03320	COG4372	Transposase
AhaeAN4_03370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AhaeAN4_03380	COG0732	type I restriction modification DNA specificity domain
AhaeAN4_03405	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AhaeAN4_03435	COG0640	Transcriptional regulator
AhaeAN4_03445	COG0798	PFAM Bile acid sodium symporter
AhaeAN4_03450	COG0431	NADPH-dependent FMN reductase
AhaeAN4_03460	COG0456	acetyltransferase
AhaeAN4_03470	COG1917	Cupin 2, conserved barrel domain protein
AhaeAN4_03475	COG5285	phytanoyl-CoA dioxygenase
AhaeAN4_03480	COG2814	Major facilitator Superfamily
AhaeAN4_03525	COG3622	Belongs to the hyi family
AhaeAN4_03530	COG2084	Dehydrogenase
AhaeAN4_03535	COG1024	Enoyl-CoA hydratase
AhaeAN4_03540	COG5002	protein histidine kinase activity
AhaeAN4_03540	COG0784	Response regulator, receiver
AhaeAN4_03540	COG2205	protein histidine kinase activity
AhaeAN4_03560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AhaeAN4_03600	COG3956	TIGRFAM MazG family protein
AhaeAN4_03605	COG1555	photosystem II stabilization
AhaeAN4_03610	COG0617	tRNA 3'-terminal CCA addition
AhaeAN4_03615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AhaeAN4_03640	COG3028	Belongs to the UPF0307 family
AhaeAN4_03645	COG0318	PFAM AMP-dependent synthetase and ligase
AhaeAN4_03665	COG0625	glutathione transferase activity
AhaeAN4_03680	COG1238	metal cluster binding
AhaeAN4_03710	COG0072	phenylalanine-tRNA ligase activity
AhaeAN4_03735	COG0248	Ppx GppA phosphatase
AhaeAN4_03745	COG0037	tRNA processing
AhaeAN4_03760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhaeAN4_03760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AhaeAN4_03785	COG1764	response to oxidative stress
AhaeAN4_03795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AhaeAN4_03860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AhaeAN4_03865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AhaeAN4_03870	COG1595	DNA-templated transcription, initiation
AhaeAN4_03880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AhaeAN4_03920	COG0494	nUDIX hydrolase
AhaeAN4_03930	COG1214	PFAM Peptidase M22, glycoprotease
AhaeAN4_03935	COG1968	undecaprenyl-diphosphatase activity
AhaeAN4_03960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AhaeAN4_03970	COG2132	Multicopper oxidase
AhaeAN4_03990	COG2076	Multidrug Resistance protein
AhaeAN4_03995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AhaeAN4_04000	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AhaeAN4_04005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AhaeAN4_04045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AhaeAN4_04060	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_04065	COG2205	protein histidine kinase activity
AhaeAN4_04090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhaeAN4_04100	COG0649	NAD binding
AhaeAN4_04100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhaeAN4_04110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AhaeAN4_04125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhaeAN4_04140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AhaeAN4_04145	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AhaeAN4_04180	COG0583	DNA-binding transcription factor activity
AhaeAN4_04185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhaeAN4_04200	COG0668	transmembrane transport
AhaeAN4_04205	COG2081	HI0933 family
AhaeAN4_04210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AhaeAN4_04240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhaeAN4_04240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AhaeAN4_04260	COG0489	protein tyrosine kinase activity
AhaeAN4_04280	COG2358	TRAP transporter, solute receptor (TAXI family
AhaeAN4_04330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AhaeAN4_04355	COG0730	response to heat
AhaeAN4_04365	COG1196	nuclear chromosome segregation
AhaeAN4_04375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AhaeAN4_04390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AhaeAN4_04400	COG2226	methyltransferase
AhaeAN4_04400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AhaeAN4_04400	COG0596	Alpha beta hydrolase
AhaeAN4_04420	COG4106	trans-aconitate 2-methyltransferase activity
AhaeAN4_04470	COG0747	negative chemotaxis
AhaeAN4_04500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AhaeAN4_04505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AhaeAN4_04525	COG0009	L-threonylcarbamoyladenylate synthase
AhaeAN4_04530	COG3101	peptidyl-lysine hydroxylation
AhaeAN4_04535	COG1399	metal-binding, possibly nucleic acid-binding protein
AhaeAN4_04540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AhaeAN4_04565	COG1652	LysM domain
AhaeAN4_04575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AhaeAN4_04575	COG0352	thiamine-phosphate diphosphorylase activity
AhaeAN4_04575	COG0351	phosphomethylpyrimidine kinase
AhaeAN4_04585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AhaeAN4_04620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AhaeAN4_04645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AhaeAN4_04675	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_04690	COG0358	DNA primase activity
AhaeAN4_04700	COG0564	pseudouridine synthase activity
AhaeAN4_04830	COG2217	Heavy metal translocating P-type atpase
AhaeAN4_04835	COG2205	protein histidine kinase activity
AhaeAN4_04850	COG2132	Multicopper oxidase
AhaeAN4_04915	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhaeAN4_04930	COG0582	viral genome integration into host DNA
AhaeAN4_04940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AhaeAN4_04965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AhaeAN4_04965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AhaeAN4_05000	COG0049	tRNA binding
AhaeAN4_05010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AhaeAN4_05025	COG0456	acetyltransferase
AhaeAN4_05035	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AhaeAN4_05040	COG0492	ferredoxin-NADP+ reductase activity
AhaeAN4_05045	COG0531	amino acid
AhaeAN4_05045	COG1674	ftsk spoiiie
AhaeAN4_05050	COG1280	lysine exporter protein (LysE YggA)
AhaeAN4_05060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AhaeAN4_05065	COG2894	cell division
AhaeAN4_05070	COG0850	regulation of cytokinetic process
AhaeAN4_05080	COG0204	Acyl-transferase
AhaeAN4_05085	COG2885	chlorophyll binding
AhaeAN4_05090	COG0210	DNA helicase
AhaeAN4_05095	COG0756	dUTP diphosphatase activity
AhaeAN4_05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AhaeAN4_05115	COG0121	glutamine amidotransferase
AhaeAN4_05130	COG2914	Belongs to the UPF0125 (RnfH) family
AhaeAN4_05135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AhaeAN4_05190	COG0420	3'-5' exonuclease activity
AhaeAN4_05210	COG1090	epimerase
AhaeAN4_05215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AhaeAN4_05225	COG2050	protein possibly involved in aromatic compounds catabolism
AhaeAN4_05230	COG1566	PFAM secretion protein HlyD family protein
AhaeAN4_05235	COG2814	Major facilitator Superfamily
AhaeAN4_05250	COG4221	oxidoreductase activity
AhaeAN4_05255	COG4689	acetoacetate decarboxylase
AhaeAN4_05265	COG1902	pentaerythritol trinitrate reductase activity
AhaeAN4_05265	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhaeAN4_05295	COG0625	glutathione transferase activity
AhaeAN4_05320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AhaeAN4_05330	COG1454	alcohol dehydrogenase
AhaeAN4_05335	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_05345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AhaeAN4_05350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AhaeAN4_05360	COG1012	belongs to the aldehyde dehydrogenase family
AhaeAN4_05375	COG0833	amino acid
AhaeAN4_05380	COG0281	malic enzyme
AhaeAN4_05385	COG1414	Transcriptional regulator
AhaeAN4_05390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhaeAN4_05410	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_05420	COG1012	belongs to the aldehyde dehydrogenase family
AhaeAN4_05425	COG1024	Enoyl-CoA hydratase
AhaeAN4_05460	COG1607	acyl-coa hydrolase
AhaeAN4_05470	COG0523	cobalamin synthesis protein
AhaeAN4_05475	COG4681	YaeQ
AhaeAN4_05520	COG2388	GCN5-related N-acetyl-transferase
AhaeAN4_05530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AhaeAN4_05575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AhaeAN4_05595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AhaeAN4_05630	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AhaeAN4_05650	COG4771	TonB-dependent receptor
AhaeAN4_05670	COG0456	acetyltransferase
AhaeAN4_05680	COG4181	ATPase activity
AhaeAN4_05685	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AhaeAN4_05695	COG0705	Rhomboid family
AhaeAN4_05695	COG0457	Tetratricopeptide repeat
AhaeAN4_05715	COG1294	oxidase, subunit
AhaeAN4_05720	COG1271	oxidase subunit
AhaeAN4_05745	COG1215	transferase activity, transferring glycosyl groups
AhaeAN4_05760	COG0415	Belongs to the DNA photolyase family
AhaeAN4_05770	COG1252	NADH dehydrogenase
AhaeAN4_05775	COG1686	Belongs to the peptidase S11 family
AhaeAN4_05825	COG0384	phenazine biosynthesis protein PhzF
AhaeAN4_05830	COG0612	Peptidase, M16
AhaeAN4_05860	COG0352	thiamine-phosphate diphosphorylase activity
AhaeAN4_05880	COG0564	pseudouridine synthase activity
AhaeAN4_05890	COG0783	Belongs to the Dps family
AhaeAN4_05920	COG1309	transcriptional regulator
AhaeAN4_05930	COG4772	TonB-dependent receptor
AhaeAN4_05940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AhaeAN4_05945	COG0076	glutamate decarboxylase activity
AhaeAN4_05960	COG0573	inorganic phosphate transmembrane transporter activity
AhaeAN4_05970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AhaeAN4_05975	COG0616	signal peptide processing
AhaeAN4_06000	COG0742	ribosomal rna small subunit methyltransferase
AhaeAN4_06005	COG0768	penicillin binding
AhaeAN4_06030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AhaeAN4_06035	COG2878	Part of a membrane complex involved in electron transport
AhaeAN4_06040	COG3501	Rhs element vgr protein
AhaeAN4_06070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AhaeAN4_06080	COG3384	dioxygenase
AhaeAN4_06095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AhaeAN4_06105	COG0789	Transcriptional regulator
AhaeAN4_06110	COG4372	Transposase
AhaeAN4_06120	COG2963	transposase activity
AhaeAN4_06125	COG4372	Transposase
AhaeAN4_06135	COG2963	transposase activity
AhaeAN4_06140	COG2217	Heavy metal translocating P-type atpase
AhaeAN4_06505	COG0006	proline dipeptidase activity
AhaeAN4_06510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhaeAN4_06515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhaeAN4_06525	COG1279	arginine transmembrane transporter activity
AhaeAN4_06530	COG0583	DNA-binding transcription factor activity
AhaeAN4_06560	COG2816	NAD+ diphosphatase activity
AhaeAN4_06570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhaeAN4_06575	COG0741	lytic transglycosylase activity
AhaeAN4_06575	COG0741	lytic transglycosylase activity
AhaeAN4_06575	COG1388	LysM domain
AhaeAN4_06575	COG1388	LysM domain
AhaeAN4_06580	COG4166	transmembrane transport
AhaeAN4_06585	COG4174	ABC transporter (Permease)
AhaeAN4_06590	COG4239	(ABC) transporter, permease
AhaeAN4_06595	COG4172	Belongs to the ABC transporter superfamily
AhaeAN4_06610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AhaeAN4_06620	COG4251	negative regulation of phosphorylation
AhaeAN4_06620	COG5001	Diguanylate cyclase
AhaeAN4_06620	COG2203	Gaf domain
AhaeAN4_06620	COG3706	GGDEF domain
AhaeAN4_06635	COG3739	integral membrane protein
AhaeAN4_06655	COG0302	gtp cyclohydrolase
AhaeAN4_06665	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_06690	COG0633	Ferredoxin
AhaeAN4_06690	COG3217	Mosc domain protein beta barrel domain protein
AhaeAN4_06705	COG0512	Glutamine amidotransferase of anthranilate synthase
AhaeAN4_06710	COG0174	glutamine synthetase
AhaeAN4_06715	COG3161	chorismate lyase activity
AhaeAN4_06720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AhaeAN4_06755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AhaeAN4_06760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AhaeAN4_06765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AhaeAN4_06770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AhaeAN4_06780	COG2223	nitrite transmembrane transporter activity
AhaeAN4_06795	COG0024	Methionine aminopeptidase
AhaeAN4_06800	COG0052	Belongs to the universal ribosomal protein uS2 family
AhaeAN4_06825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AhaeAN4_06830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AhaeAN4_06835	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AhaeAN4_06860	COG2011	ABC-type metal ion transport system permease component
AhaeAN4_06865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AhaeAN4_06870	COG1464	Belongs to the NlpA lipoprotein family
AhaeAN4_06875	COG0151	Belongs to the GarS family
AhaeAN4_06880	COG0138	bifunctional purine biosynthesis protein purh
AhaeAN4_06885	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AhaeAN4_06965	COG2252	PERMEase
AhaeAN4_06970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AhaeAN4_06975	COG3038	cytochrome b561
AhaeAN4_06985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AhaeAN4_06995	COG0527	aspartate kinase activity
AhaeAN4_07005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AhaeAN4_07025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AhaeAN4_07040	COG2308	Evidence 4 Homologs of previously reported genes of
AhaeAN4_07050	COG1305	Transglutaminase-like
AhaeAN4_07065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AhaeAN4_07070	COG0305	Participates in initiation and elongation during chromosome replication
AhaeAN4_07075	COG1733	regulation of RNA biosynthetic process
AhaeAN4_07080	COG2249	NAD(P)H dehydrogenase (quinone) activity
AhaeAN4_07105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AhaeAN4_07110	COG1845	cytochrome c oxidase, subunit III
AhaeAN4_07115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AhaeAN4_07120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AhaeAN4_07140	COG3300	MHYT domain
AhaeAN4_07140	COG5001	Diguanylate cyclase
AhaeAN4_07145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AhaeAN4_07175	COG0802	atpase or kinase
AhaeAN4_07180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AhaeAN4_07190	COG1923	regulation of RNA biosynthetic process
AhaeAN4_07195	COG0697	spore germination
AhaeAN4_07205	COG2249	NAD(P)H dehydrogenase (quinone) activity
AhaeAN4_07215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhaeAN4_07225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhaeAN4_07240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AhaeAN4_07255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AhaeAN4_07275	COG3634	alkyl hydroperoxide reductase activity
AhaeAN4_07295	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhaeAN4_07305	COG0450	alkyl hydroperoxide reductase
AhaeAN4_07310	COG1643	Atp-dependent helicase
AhaeAN4_07325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AhaeAN4_07350	COG2951	lytic endotransglycosylase activity
AhaeAN4_07355	COG0772	Belongs to the SEDS family
AhaeAN4_07370	COG0842	Transport permease protein
AhaeAN4_07375	COG1131	(ABC) transporter
AhaeAN4_07380	COG0583	DNA-binding transcription factor activity
AhaeAN4_07390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AhaeAN4_07400	COG3659	wide pore channel activity
AhaeAN4_07500	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_07535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AhaeAN4_07560	COG0729	surface antigen
AhaeAN4_07585	COG0471	metal ion transport
AhaeAN4_07590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhaeAN4_07610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AhaeAN4_07615	COG4605	iron ion homeostasis
AhaeAN4_07620	COG4604	ABC transporter, ATP-binding protein
AhaeAN4_07625	COG4607	ABC-type enterochelin transport system periplasmic component
AhaeAN4_07630	COG2814	Major facilitator Superfamily
AhaeAN4_07640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AhaeAN4_07645	COG0583	DNA-binding transcription factor activity
AhaeAN4_07680	COG1720	tRNA m6t6A37 methyltransferase activity
AhaeAN4_07705	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_07710	COG0642	Histidine kinase
AhaeAN4_07720	COG0494	nUDIX hydrolase
AhaeAN4_07730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AhaeAN4_07740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AhaeAN4_07745	COG3139	Protein of unknown function (DUF1315)
AhaeAN4_07750	COG3501	Rhs element vgr protein
AhaeAN4_07770	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_07775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AhaeAN4_07780	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_07795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AhaeAN4_07855	COG3539	Fimbrial protein
AhaeAN4_07880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AhaeAN4_07880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AhaeAN4_07900	COG1278	Cold shock
AhaeAN4_07910	COG1278	Cold shock
AhaeAN4_07930	COG3042	response to heat
AhaeAN4_07945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AhaeAN4_07950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AhaeAN4_07975	COG2353	YceI-like domain
AhaeAN4_07980	COG3153	acetyltransferase
AhaeAN4_07995	COG3698	Phosphodiester glycosidase
AhaeAN4_08005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AhaeAN4_08015	COG0506	proline dehydrogenase activity
AhaeAN4_08015	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AhaeAN4_08015	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AhaeAN4_08025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhaeAN4_08045	COG1132	(ABC) transporter
AhaeAN4_08095	COG0640	Transcriptional regulator
AhaeAN4_08135	COG2850	peptidyl-arginine hydroxylation
AhaeAN4_08155	COG4372	Transposase
AhaeAN4_08165	COG2963	transposase activity
AhaeAN4_08170	COG1454	alcohol dehydrogenase
AhaeAN4_08175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AhaeAN4_08195	COG0069	glutamate synthase activity
AhaeAN4_08210	COG2814	Major facilitator Superfamily
AhaeAN4_08225	COG0439	Biotin carboxylase
AhaeAN4_08240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhaeAN4_08240	COG1116	anion transmembrane transporter activity
AhaeAN4_08250	COG2223	nitrite transmembrane transporter activity
AhaeAN4_08255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhaeAN4_08255	COG2146	nitrite reductase [NAD(P)H] activity
AhaeAN4_08260	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhaeAN4_08265	COG0243	molybdopterin cofactor binding
AhaeAN4_08295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AhaeAN4_08310	COG0315	cyclic pyranopterin monophosphate synthase activity
AhaeAN4_08310	COG0521	Mo-molybdopterin cofactor biosynthetic process
AhaeAN4_08315	COG0303	'Molybdopterin
AhaeAN4_08335	COG0697	spore germination
AhaeAN4_08355	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AhaeAN4_08405	COG1309	transcriptional regulator
AhaeAN4_08410	COG2204	response regulator
AhaeAN4_08415	COG3852	Histidine kinase
AhaeAN4_08425	COG0528	UMP kinase activity
AhaeAN4_08435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AhaeAN4_08440	COG0575	Belongs to the CDS family
AhaeAN4_08475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhaeAN4_08495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhaeAN4_08500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AhaeAN4_08505	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_08510	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_08555	COG2814	Major facilitator Superfamily
AhaeAN4_08570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AhaeAN4_08585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AhaeAN4_08590	COG0406	alpha-ribazole phosphatase activity
AhaeAN4_08610	COG4771	TonB-dependent receptor
AhaeAN4_08620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhaeAN4_08625	COG0730	response to heat
AhaeAN4_08645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AhaeAN4_08670	COG0537	adenosine 5'-monophosphoramidase activity
AhaeAN4_08715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AhaeAN4_08735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AhaeAN4_08755	COG3706	GGDEF domain
AhaeAN4_08765	COG2249	NAD(P)H dehydrogenase (quinone) activity
AhaeAN4_08825	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_08835	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_08840	COG4774	siderophore transport
AhaeAN4_08850	COG0583	DNA-binding transcription factor activity
AhaeAN4_08870	COG2814	Major facilitator Superfamily
AhaeAN4_08885	COG0318	PFAM AMP-dependent synthetase and ligase
AhaeAN4_08890	COG1309	transcriptional regulator
AhaeAN4_08895	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_08900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AhaeAN4_08905	COG1024	Enoyl-CoA hydratase
AhaeAN4_08910	COG4770	biotin carboxylase activity
AhaeAN4_08920	COG0583	DNA-binding transcription factor activity
AhaeAN4_08980	COG1595	DNA-templated transcription, initiation
AhaeAN4_08985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AhaeAN4_08995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhaeAN4_09000	COG0864	Transcriptional regulator
AhaeAN4_09010	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_09020	COG0439	Biotin carboxylase
AhaeAN4_09035	COG1522	sequence-specific DNA binding
AhaeAN4_09050	COG2963	transposase activity
AhaeAN4_09060	COG4372	Transposase
AhaeAN4_09070	COG1944	ATP diphosphatase activity
AhaeAN4_09090	COG2207	Transcriptional regulator
AhaeAN4_09100	COG1802	Transcriptional regulator
AhaeAN4_09115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AhaeAN4_09125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhaeAN4_09185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AhaeAN4_09190	COG0148	phosphopyruvate hydratase activity
AhaeAN4_09225	COG1902	pentaerythritol trinitrate reductase activity
AhaeAN4_09225	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhaeAN4_09235	COG2267	carboxylic ester hydrolase activity
AhaeAN4_09240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AhaeAN4_09250	COG0542	response to heat
AhaeAN4_09255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AhaeAN4_09265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AhaeAN4_09300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AhaeAN4_09305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AhaeAN4_09310	COG0569	domain protein
AhaeAN4_09315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhaeAN4_09335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AhaeAN4_09360	COG1294	oxidase, subunit
AhaeAN4_09365	COG4890	Cyd operon protein YbgT
AhaeAN4_09395	COG0552	protein localization to endoplasmic reticulum
AhaeAN4_09420	COG0517	IMP dehydrogenase activity
AhaeAN4_09420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AhaeAN4_09425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AhaeAN4_09430	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AhaeAN4_09440	COG0583	DNA-binding transcription factor activity
AhaeAN4_09445	COG0024	Methionine aminopeptidase
AhaeAN4_09485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AhaeAN4_09490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AhaeAN4_09505	COG2431	L-lysine efflux transmembrane transporter activity
AhaeAN4_09520	COG0776	regulation of translation
AhaeAN4_09585	COG0084	hydrolase, TatD family'
AhaeAN4_09610	COG1663	tetraacyldisaccharide 4'-kinase activity
AhaeAN4_09615	COG1132	(ABC) transporter
AhaeAN4_09625	COG0811	peptide transport
AhaeAN4_09630	COG1475	DNA binding
AhaeAN4_09635	COG1192	Involved in chromosome partitioning
AhaeAN4_09645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AhaeAN4_09660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AhaeAN4_09670	COG0513	Belongs to the DEAD box helicase family
AhaeAN4_09690	COG2363	Small membrane protein
AhaeAN4_09735	COG3550	peptidyl-serine autophosphorylation
AhaeAN4_09750	COG2195	Cleaves the N-terminal amino acid of tripeptides
AhaeAN4_09780	COG1464	Belongs to the NlpA lipoprotein family
AhaeAN4_09785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AhaeAN4_09790	COG2011	ABC-type metal ion transport system permease component
AhaeAN4_09795	COG0012	GTP binding
AhaeAN4_09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AhaeAN4_09810	COG1253	flavin adenine dinucleotide binding
AhaeAN4_09835	COG0436	Aminotransferase
AhaeAN4_09845	COG1522	sequence-specific DNA binding
AhaeAN4_09855	COG0386	Belongs to the glutathione peroxidase family
AhaeAN4_09860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AhaeAN4_09865	COG0436	Aminotransferase
AhaeAN4_09905	COG3634	alkyl hydroperoxide reductase activity
AhaeAN4_09960	COG1286	toxin biosynthetic process
AhaeAN4_10015	COG0424	maF-like protein
AhaeAN4_10020	COG0583	DNA-binding transcription factor activity
AhaeAN4_10025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AhaeAN4_10070	COG0183	Belongs to the thiolase family
AhaeAN4_10090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AhaeAN4_10095	COG0702	epimerase
AhaeAN4_10100	COG0268	Binds directly to 16S ribosomal RNA
AhaeAN4_10120	COG1218	3'(2'),5'-bisphosphate nucleotidase
AhaeAN4_10125	COG1011	Hydrolase
AhaeAN4_10130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AhaeAN4_10140	COG2137	regulation of response to DNA damage stimulus
AhaeAN4_10155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AhaeAN4_10160	COG0776	regulation of translation
AhaeAN4_10185	COG0822	iron-sulfur transferase activity
AhaeAN4_10190	COG0316	Belongs to the HesB IscA family
AhaeAN4_10220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AhaeAN4_10240	COG0583	DNA-binding transcription factor activity
AhaeAN4_10245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AhaeAN4_10255	COG3135	benzoate transporter
AhaeAN4_10260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AhaeAN4_10260	COG0475	glutathione-regulated potassium exporter activity
AhaeAN4_10270	COG1714	RDD family
AhaeAN4_10290	COG1760	l-serine dehydratase
AhaeAN4_10295	COG0308	aminopeptidase N
AhaeAN4_10325	COG4133	protoheme IX ABC transporter activity
AhaeAN4_10375	COG1765	OsmC-like protein
AhaeAN4_10385	COG0501	Belongs to the peptidase M48B family
AhaeAN4_10390	COG4770	biotin carboxylase activity
AhaeAN4_10395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AhaeAN4_10400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AhaeAN4_10405	COG1560	Kdo2-lipid A biosynthetic process
AhaeAN4_10410	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AhaeAN4_10415	COG2072	flavoprotein involved in K transport
AhaeAN4_10435	COG1309	transcriptional regulator
AhaeAN4_10455	COG0642	Histidine kinase
AhaeAN4_10460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AhaeAN4_10470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AhaeAN4_10490	COG3040	lipid binding
AhaeAN4_10495	COG5002	protein histidine kinase activity
AhaeAN4_10500	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_10505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhaeAN4_10510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhaeAN4_10515	COG1538	Outer membrane efflux protein
AhaeAN4_10525	COG2837	iron assimilation
AhaeAN4_10530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AhaeAN4_10535	COG0243	molybdopterin cofactor binding
AhaeAN4_10570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AhaeAN4_10575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AhaeAN4_10580	COG0010	Belongs to the arginase family
AhaeAN4_10600	COG2188	Transcriptional regulator
AhaeAN4_10610	COG0583	DNA-binding transcription factor activity
AhaeAN4_10625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AhaeAN4_10635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhaeAN4_10650	COG4266	Belongs to the allantoicase family
AhaeAN4_10660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhaeAN4_10680	COG2233	PERMEase
AhaeAN4_10685	COG2351	hydroxyisourate hydrolase activity
AhaeAN4_10695	COG4993	Dehydrogenase
AhaeAN4_10700	COG3659	wide pore channel activity
AhaeAN4_10705	COG3420	alginic acid biosynthetic process
AhaeAN4_10710	COG0710	3-dehydroquinate dehydratase activity
AhaeAN4_10715	COG3485	protocatechuate 3,4-dioxygenase
AhaeAN4_10720	COG3485	protocatechuate 3,4-dioxygenase
AhaeAN4_10725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AhaeAN4_10730	COG2271	Major facilitator Superfamily
AhaeAN4_10735	COG0596	Alpha beta hydrolase
AhaeAN4_10740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AhaeAN4_10745	COG0183	Belongs to the thiolase family
AhaeAN4_10750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AhaeAN4_10755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AhaeAN4_10760	COG1414	Transcriptional regulator
AhaeAN4_10775	COG1469	GTP cyclohydrolase I activity
AhaeAN4_10780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AhaeAN4_10790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AhaeAN4_10820	COG2161	toxin-antitoxin pair type II binding
AhaeAN4_10825	COG4115	mRNA cleavage
AhaeAN4_10835	COG0582	viral genome integration into host DNA
AhaeAN4_10845	COG0446	pyridine nucleotide-disulphide oxidoreductase
AhaeAN4_10845	COG1902	pentaerythritol trinitrate reductase activity
AhaeAN4_10860	COG1741	Belongs to the pirin family
AhaeAN4_11225	COG0714	Associated with various cellular activities
AhaeAN4_11230	COG2879	small protein
AhaeAN4_11235	COG1966	Carbon starvation protein
AhaeAN4_11240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AhaeAN4_11245	COG1509	lysine 2,3-aminomutase activity
AhaeAN4_11260	COG0254	rRNA binding
AhaeAN4_11290	COG1067	ATP-dependent peptidase activity
AhaeAN4_11295	COG0583	DNA-binding transcription factor activity
AhaeAN4_11305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AhaeAN4_11325	COG1686	Belongs to the peptidase S11 family
AhaeAN4_11330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AhaeAN4_11365	COG0028	Belongs to the TPP enzyme family
AhaeAN4_11440	COG1610	YqeY-like protein
AhaeAN4_11460	COG4783	chaperone-mediated protein folding
AhaeAN4_11490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AhaeAN4_11525	COG0583	DNA-binding transcription factor activity
AhaeAN4_11550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AhaeAN4_11560	COG4122	O-methyltransferase activity
AhaeAN4_11595	COG1137	ATPase activity
AhaeAN4_11600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AhaeAN4_11610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AhaeAN4_11615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AhaeAN4_11615	COG0517	IMP dehydrogenase activity
AhaeAN4_11735	COG3728	DNA packaging
AhaeAN4_11735	COG5484	DNA packaging
AhaeAN4_11830	COG3015	lipoprotein NlpE involved in copper resistance
AhaeAN4_11845	COG1253	flavin adenine dinucleotide binding
AhaeAN4_11850	COG0222	ribosome binding
AhaeAN4_11865	COG0175	sulfate reduction
AhaeAN4_11875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AhaeAN4_11885	COG1773	rubredoxin
AhaeAN4_11890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhaeAN4_11895	COG0596	Alpha beta hydrolase
AhaeAN4_11900	COG0583	DNA-binding transcription factor activity
AhaeAN4_11925	COG1840	ABC-type Fe3 transport system, periplasmic component
AhaeAN4_11970	COG0556	nucleotide-excision repair
AhaeAN4_11995	COG0436	Aminotransferase
AhaeAN4_12020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AhaeAN4_12035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AhaeAN4_12040	COG0571	ribonuclease III activity
AhaeAN4_12055	COG0481	GTPase activity
AhaeAN4_12065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AhaeAN4_12085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AhaeAN4_12090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AhaeAN4_12095	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AhaeAN4_12105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AhaeAN4_12110	COG4208	sulfate ABC transporter
AhaeAN4_12115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AhaeAN4_12120	COG0583	DNA-binding transcription factor activity
AhaeAN4_12135	COG0602	queuosine metabolic process
AhaeAN4_12140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AhaeAN4_12155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AhaeAN4_12175	COG1942	4-Oxalocrotonate Tautomerase
AhaeAN4_12180	COG0583	DNA-binding transcription factor activity
AhaeAN4_12185	COG1051	belongs to the nudix hydrolase family
AhaeAN4_12185	COG1056	cytidyltransferase-related domain
AhaeAN4_12190	COG1024	Enoyl-CoA hydratase
AhaeAN4_12195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AhaeAN4_12195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AhaeAN4_12200	COG1105	Belongs to the carbohydrate kinase PfkB family
AhaeAN4_12205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhaeAN4_12205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AhaeAN4_12205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AhaeAN4_12210	COG0778	Nitroreductase
AhaeAN4_12215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AhaeAN4_12215	COG3323	Protein of unknown function (DUF1653)
AhaeAN4_12235	COG0047	phosphoribosylformylglycinamidine synthase activity
AhaeAN4_12235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AhaeAN4_12250	COG2255	four-way junction helicase activity
AhaeAN4_12260	COG0824	Thioesterase
AhaeAN4_12280	COG0823	Involved in the tonB-independent uptake of proteins
AhaeAN4_12300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AhaeAN4_12345	COG0628	permease
AhaeAN4_12355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AhaeAN4_12365	COG0616	signal peptide processing
AhaeAN4_12365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AhaeAN4_12375	COG0658	competence protein
AhaeAN4_12375	COG2333	competence protein COMEC
AhaeAN4_12380	COG1136	(ABC) transporter
AhaeAN4_12385	COG4591	ABC-type transport system involved in lipoprotein release permease component
AhaeAN4_12400	COG1671	Belongs to the UPF0178 family
AhaeAN4_12430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhaeAN4_12440	COG0842	Transport permease protein
AhaeAN4_12455	COG2318	DinB family
AhaeAN4_12470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AhaeAN4_12475	COG1280	lysine exporter protein (LysE YggA)
AhaeAN4_12485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AhaeAN4_12490	COG0019	diaminopimelate decarboxylase activity
AhaeAN4_12500	COG1115	amino acid carrier protein
AhaeAN4_12530	COG2963	transposase activity
AhaeAN4_12540	COG4372	Transposase
AhaeAN4_12545	COG0306	phosphate transporter
AhaeAN4_12580	COG0242	peptide deformylase activity
AhaeAN4_12595	COG0589	response to stress
AhaeAN4_12625	COG2175	clavaminate synthase activity
AhaeAN4_12630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AhaeAN4_12635	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AhaeAN4_12640	COG4521	taurine ABC transporter
AhaeAN4_12660	COG4149	molybdate abc transporter
AhaeAN4_12665	COG0725	ABC transporter, periplasmic molybdate-binding protein
AhaeAN4_12720	COG0174	glutamine synthetase
AhaeAN4_12725	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_12730	COG2205	protein histidine kinase activity
AhaeAN4_12735	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AhaeAN4_12740	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AhaeAN4_12745	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AhaeAN4_12750	COG0569	domain protein
AhaeAN4_12755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AhaeAN4_12855	COG0582	viral genome integration into host DNA
AhaeAN4_12865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AhaeAN4_12870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AhaeAN4_12885	COG1196	nuclear chromosome segregation
AhaeAN4_12885	COG0741	lytic transglycosylase activity
AhaeAN4_12885	COG0739	heme binding
AhaeAN4_12890	COG0501	Belongs to the peptidase M48B family
AhaeAN4_12900	COG2239	Acts as a magnesium transporter
AhaeAN4_12905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AhaeAN4_12910	COG2194	sulfuric ester hydrolase activity
AhaeAN4_12915	COG0584	glycerophosphoryl diester phosphodiesterase
AhaeAN4_12940	COG2304	oxidoreductase activity
AhaeAN4_12950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AhaeAN4_12975	COG0505	Belongs to the CarA family
AhaeAN4_12990	COG2801	Transposase and inactivated derivatives
AhaeAN4_13000	COG0110	maltose O-acetyltransferase activity
AhaeAN4_13035	COG2321	neutral zinc metallopeptidase
AhaeAN4_13040	COG2354	Protein conserved in bacteria
AhaeAN4_13050	COG1585	Membrane protein implicated in regulation of membrane protease activity
AhaeAN4_13055	COG2268	Band 7 protein
AhaeAN4_13070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AhaeAN4_13090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AhaeAN4_13095	COG1053	succinate dehydrogenase
AhaeAN4_13100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AhaeAN4_13105	COG2009	succinate dehydrogenase
AhaeAN4_13130	COG0586	Pfam SNARE associated Golgi protein
AhaeAN4_13135	COG0500	methyltransferase
AhaeAN4_13145	COG1280	lysine exporter protein (LysE YggA)
AhaeAN4_13180	COG0321	lipoyl(octanoyl) transferase activity
AhaeAN4_13195	COG0531	amino acid
AhaeAN4_13205	COG1733	regulation of RNA biosynthetic process
AhaeAN4_13215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AhaeAN4_13220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AhaeAN4_13220	COG1648	precorrin-2 dehydrogenase activity
AhaeAN4_13235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AhaeAN4_13270	COG0671	phosphoesterase, PA-phosphatase related
AhaeAN4_13275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhaeAN4_13285	COG1538	Outer membrane efflux protein
AhaeAN4_13290	COG0393	Putative heavy-metal-binding
AhaeAN4_13305	COG1028	Short-chain dehydrogenase reductase Sdr
AhaeAN4_13320	COG0525	valine-tRNA ligase activity
AhaeAN4_13335	COG4372	Transposase
AhaeAN4_13345	COG2963	transposase activity
AhaeAN4_13360	COG2852	Protein conserved in bacteria
AhaeAN4_13375	COG0004	ammonium transporteR
AhaeAN4_13385	COG0765	amino acid transport
AhaeAN4_13390	COG0765	amino acid transport
AhaeAN4_13395	COG1126	abc transporter atp-binding protein
AhaeAN4_13405	COG0642	Histidine kinase
AhaeAN4_13410	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_13415	COG2194	sulfuric ester hydrolase activity
AhaeAN4_13445	COG1752	Esterase of the alpha-beta hydrolase superfamily
AhaeAN4_13460	COG0142	geranyltranstransferase activity
AhaeAN4_13470	COG1113	amino acid transport
AhaeAN4_13495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AhaeAN4_13505	COG0671	phosphoesterase, PA-phosphatase related
AhaeAN4_13525	COG0560	Phosphoserine phosphatase
AhaeAN4_13535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AhaeAN4_13545	COG1530	ribonuclease E activity
AhaeAN4_13550	COG0424	maF-like protein
AhaeAN4_13560	COG1792	Involved in formation and maintenance of cell shape
AhaeAN4_13565	COG1077	Cell shape determining protein MreB Mrl
AhaeAN4_13570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AhaeAN4_13580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AhaeAN4_13625	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AhaeAN4_13630	COG1752	Esterase of the alpha-beta hydrolase superfamily
AhaeAN4_13635	COG1115	amino acid carrier protein
AhaeAN4_13640	COG0786	glutamate:sodium symporter activity
AhaeAN4_13655	COG2814	Major facilitator Superfamily
AhaeAN4_13660	COG1289	transmembrane transporter activity
AhaeAN4_13670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AhaeAN4_13715	COG1376	ErfK ybiS ycfS ynhG family protein
AhaeAN4_13720	COG2832	Protein of unknown function (DUF454)
AhaeAN4_13730	COG5510	response to toxic substance
AhaeAN4_13745	COG0643	Histidine kinase
AhaeAN4_13745	COG2198	Histidine kinase
AhaeAN4_13745	COG2198	Histidine kinase
AhaeAN4_13745	COG0643	Histidine kinase
AhaeAN4_13750	COG0840	transmembrane signaling receptor activity
AhaeAN4_13780	COG3422	double-strand break repair
AhaeAN4_13785	COG2824	Alkylphosphonate utilization operon protein PhnA
AhaeAN4_13795	COG0354	folic acid binding
AhaeAN4_13805	COG4772	TonB-dependent receptor
AhaeAN4_13830	COG2801	Transposase and inactivated derivatives
AhaeAN4_13835	COG2963	transposase activity
AhaeAN4_13845	COG4372	Transposase
AhaeAN4_13860	COG2233	PERMEase
AhaeAN4_13870	COG0833	amino acid
AhaeAN4_13875	COG1690	Belongs to the RtcB family
AhaeAN4_13880	COG2885	chlorophyll binding
AhaeAN4_13880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AhaeAN4_13885	COG2885	chlorophyll binding
AhaeAN4_13885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AhaeAN4_13895	COG0183	Belongs to the thiolase family
AhaeAN4_13910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AhaeAN4_13940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AhaeAN4_13945	COG2207	Transcriptional regulator
AhaeAN4_13955	COG0183	Belongs to the thiolase family
AhaeAN4_13960	COG1024	Enoyl-CoA hydratase
AhaeAN4_13960	COG1250	3-hydroxyacyl-CoA dehydrogenase
AhaeAN4_14000	COG1272	protein, Hemolysin III
AhaeAN4_14005	COG0477	Major facilitator Superfamily
AhaeAN4_14025	COG0450	alkyl hydroperoxide reductase
AhaeAN4_14040	COG0285	dihydrofolate synthase activity
AhaeAN4_14090	COG4206	TonB-dependent receptor
AhaeAN4_14095	COG2096	Adenosyltransferase
AhaeAN4_14115	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AhaeAN4_14135	COG0745	RESPONSE REGULATOR receiver
AhaeAN4_14140	COG2205	protein histidine kinase activity
AhaeAN4_14150	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_14155	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_14195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AhaeAN4_14265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AhaeAN4_14275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AhaeAN4_14280	COG0784	Response regulator, receiver
AhaeAN4_14280	COG5002	protein histidine kinase activity
AhaeAN4_14280	COG2205	protein histidine kinase activity
AhaeAN4_14315	COG1862	Preprotein translocase
AhaeAN4_14325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AhaeAN4_14360	COG1426	Protein conserved in bacteria
AhaeAN4_14380	COG2975	iron-sulfur cluster assembly
AhaeAN4_14395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AhaeAN4_14400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AhaeAN4_14405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AhaeAN4_14415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AhaeAN4_14420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AhaeAN4_14425	COG0625	glutathione transferase activity
AhaeAN4_14430	COG2969	positive regulation of protein catabolic process
AhaeAN4_14485	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_14490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AhaeAN4_14505	COG1309	transcriptional regulator
AhaeAN4_14520	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_14560	COG2199	diguanylate cyclase activity
AhaeAN4_14570	COG1408	metallophosphoesterase
AhaeAN4_14575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AhaeAN4_14585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AhaeAN4_14605	COG0793	Belongs to the peptidase S41A family
AhaeAN4_14620	COG2267	carboxylic ester hydrolase activity
AhaeAN4_14630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AhaeAN4_14635	COG0280	phosphate acetyltransferase
AhaeAN4_14635	COG0857	belongs to the CobB CobQ family
AhaeAN4_14670	COG2207	Transcriptional regulator
AhaeAN4_14670	COG1917	Cupin 2, conserved barrel domain protein
AhaeAN4_14675	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AhaeAN4_14675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AhaeAN4_14695	COG0740	serine-type endopeptidase activity
AhaeAN4_14705	COG4771	TonB-dependent receptor
AhaeAN4_14710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AhaeAN4_14720	COG2813	Specifically methylates the guanine in position
AhaeAN4_14720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AhaeAN4_14745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AhaeAN4_14775	COG1295	ribonuclease BN
AhaeAN4_14785	COG2207	Transcriptional regulator
AhaeAN4_14795	COG0179	Fumarylacetoacetate (FAA) hydrolase
AhaeAN4_14830	COG2963	transposase activity
AhaeAN4_14840	COG4372	Transposase
AhaeAN4_14890	COG0557	exoribonuclease II activity
AhaeAN4_14905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AhaeAN4_14920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AhaeAN4_14930	COG0644	oxidoreductase
AhaeAN4_14930	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AhaeAN4_14935	COG0425	Belongs to the sulfur carrier protein TusA family
AhaeAN4_14940	COG4535	Mg2 and Co2 transporter CorC
AhaeAN4_14945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AhaeAN4_14965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AhaeAN4_14975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AhaeAN4_14990	COG0789	Transcriptional regulator
AhaeAN4_14995	COG0598	Magnesium transport protein CorA
AhaeAN4_15000	COG1185	polyribonucleotide nucleotidyltransferase activity
AhaeAN4_15005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AhaeAN4_15015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AhaeAN4_15020	COG1074	ATP-dependent DNA helicase activity
AhaeAN4_15025	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AhaeAN4_15050	COG2226	methyltransferase
AhaeAN4_15065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhaeAN4_15080	COG1116	anion transmembrane transporter activity
AhaeAN4_15085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AhaeAN4_15095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AhaeAN4_15110	COG2111	Na H antiporter
AhaeAN4_15110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AhaeAN4_15115	COG1006	Multisubunit Na H antiporter MnhC subunit
AhaeAN4_15120	COG0651	ATP synthesis coupled electron transport
AhaeAN4_15125	COG1863	multisubunit Na H antiporter MnhE subunit
AhaeAN4_15130	COG2212	antiporter activity
AhaeAN4_15160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AhaeAN4_15170	COG0195	Participates in both transcription termination and antitermination
AhaeAN4_15220	COG0237	dephospho-CoA kinase activity
AhaeAN4_15235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AhaeAN4_15245	COG0497	DNA recombination
AhaeAN4_15255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AhaeAN4_15280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AhaeAN4_15335	COG1132	(ABC) transporter
AhaeAN4_15350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AhaeAN4_15365	COG0326	Molecular chaperone. Has ATPase activity
AhaeAN4_15375	COG2056	Na+-H+ antiporter family
AhaeAN4_15425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AhaeAN4_15435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AhaeAN4_15445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AhaeAN4_15475	COG0546	phosphoglycolate phosphatase activity
AhaeAN4_15525	COG0181	hydroxymethylbilane synthase activity
AhaeAN4_15540	COG3275	phosphorelay sensor kinase activity
AhaeAN4_15565	COG0494	nUDIX hydrolase
AhaeAN4_15575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AhaeAN4_15580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AhaeAN4_15585	COG0772	Belongs to the SEDS family
AhaeAN4_15610	COG4974	Belongs to the 'phage' integrase family
AhaeAN4_15615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhaeAN4_15625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AhaeAN4_15630	COG1686	Belongs to the peptidase S11 family
AhaeAN4_15635	COG2197	response regulator
AhaeAN4_15650	COG0793	Belongs to the peptidase S41A family
AhaeAN4_15655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AhaeAN4_15660	COG0795	lipopolysaccharide-transporting ATPase activity
AhaeAN4_15665	COG0795	lipopolysaccharide-transporting ATPase activity
AhaeAN4_15700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AhaeAN4_15700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AhaeAN4_15705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AhaeAN4_15710	COG0004	ammonium transporteR
AhaeAN4_15715	COG0347	Belongs to the P(II) protein family
AhaeAN4_15805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AhaeAN4_15810	COG1230	cation diffusion facilitator family transporter
AhaeAN4_15820	COG2963	transposase activity
AhaeAN4_15830	COG4372	Transposase
AhaeAN4_15835	COG0640	Transcriptional regulator
AhaeAN4_15845	COG0789	Transcriptional regulator
AhaeAN4_15875	COG2814	Major facilitator Superfamily
AhaeAN4_15920	COG0633	Ferredoxin
AhaeAN4_15975	COG0606	chelatase, subunit chli
AhaeAN4_16010	COG0318	PFAM AMP-dependent synthetase and ligase
AhaeAN4_16025	COG2860	membrane
AhaeAN4_16035	COG1253	flavin adenine dinucleotide binding
AhaeAN4_16055	COG2814	Major facilitator Superfamily
AhaeAN4_16065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AhaeAN4_16090	COG2814	Major facilitator Superfamily
AhaeAN4_16100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AhaeAN4_16105	COG1283	sodium-dependent phosphate transmembrane transporter activity
AhaeAN4_16135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AhaeAN4_16150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AhaeAN4_16155	COG3162	membrane
AhaeAN4_16160	COG2205	protein histidine kinase activity
AhaeAN4_16185	COG1652	LysM domain
AhaeAN4_16190	COG0758	DNA mediated transformation
AhaeAN4_16205	COG1309	transcriptional regulator
AhaeAN4_16215	COG2814	Major facilitator Superfamily
AhaeAN4_16225	COG0386	Belongs to the glutathione peroxidase family
AhaeAN4_16240	COG3328	transposase activity
AhaeAN4_16255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AhaeAN4_16265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AhaeAN4_16305	COG1121	(ABC) transporter
AhaeAN4_16310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AhaeAN4_16315	COG1280	lysine exporter protein (LysE YggA)
AhaeAN4_16320	COG2837	iron assimilation
AhaeAN4_16355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AhaeAN4_16375	COG0519	Catalyzes the synthesis of GMP from XMP
AhaeAN4_16375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AhaeAN4_16380	COG4399	Belongs to the UPF0754 family
AhaeAN4_16390	COG2259	Doxx family
AhaeAN4_16395	COG0586	Pfam SNARE associated Golgi protein
AhaeAN4_16410	COG1192	Involved in chromosome partitioning
AhaeAN4_16420	COG0271	Belongs to the BolA IbaG family
AhaeAN4_16455	COG3756	Protein conserved in bacteria
AhaeAN4_16480	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_16495	COG2304	oxidoreductase activity
AhaeAN4_16570	COG2826	transposase and inactivated derivatives, IS30 family
AhaeAN4_16680	COG0735	belongs to the Fur family
AhaeAN4_16750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AhaeAN4_16760	COG4115	mRNA cleavage
AhaeAN4_16775	COG0477	Major facilitator Superfamily
AhaeAN4_16780	COG1024	Enoyl-CoA hydratase
AhaeAN4_16785	COG1024	Enoyl-CoA hydratase
AhaeAN4_16790	COG1960	acyl-CoA dehydrogenase activity
AhaeAN4_16795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AhaeAN4_16815	COG1113	amino acid transport
AhaeAN4_16820	COG0251	oxidation-reduction process
AhaeAN4_16850	COG0456	acetyltransferase
AhaeAN4_16855	COG0564	pseudouridine synthase activity
AhaeAN4_16860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AhaeAN4_16885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AhaeAN4_16900	COG1802	Transcriptional regulator
AhaeAN4_16910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AhaeAN4_16915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AhaeAN4_16930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AhaeAN4_16940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AhaeAN4_16950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AhaeAN4_16970	COG1045	serine acetyltransferase
AhaeAN4_17000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AhaeAN4_17035	COG3023	N-Acetylmuramoyl-L-alanine amidase
AhaeAN4_17095	COG0546	phosphoglycolate phosphatase activity
AhaeAN4_17100	COG1028	Short-chain dehydrogenase reductase Sdr
AhaeAN4_17110	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AhaeAN4_17110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AhaeAN4_17115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhaeAN4_17120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AhaeAN4_17125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AhaeAN4_17130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AhaeAN4_17135	COG1116	anion transmembrane transporter activity
AhaeAN4_17140	COG1309	transcriptional regulator
AhaeAN4_17165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AhaeAN4_17175	COG0196	riboflavin kinase activity
AhaeAN4_17180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AhaeAN4_17190	COG1047	Peptidyl-prolyl cis-trans
AhaeAN4_17230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AhaeAN4_17255	COG0583	DNA-binding transcription factor activity
AhaeAN4_17265	COG0443	Heat shock 70 kDa protein
AhaeAN4_17270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AhaeAN4_17300	COG2951	lytic endotransglycosylase activity
AhaeAN4_17310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AhaeAN4_17330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AhaeAN4_17360	COG0861	Integral membrane protein TerC family
AhaeAN4_17365	COG0402	S-adenosylhomocysteine deaminase activity
AhaeAN4_17380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AhaeAN4_17390	COG0706	membrane insertase activity
AhaeAN4_17435	COG1063	alcohol dehydrogenase
AhaeAN4_17440	COG4716	Myosin-crossreactive antigen
AhaeAN4_17510	COG2801	Transposase and inactivated derivatives
AhaeAN4_17555	COG0582	viral genome integration into host DNA
AhaeAN4_17655	COG1570	exodeoxyribonuclease VII activity
AhaeAN4_17675	COG1877	trehalose-phosphatase activity
AhaeAN4_17680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AhaeAN4_17685	COG2223	nitrite transmembrane transporter activity
AhaeAN4_17730	COG2323	membrane
AhaeAN4_17745	COG1063	alcohol dehydrogenase
AhaeAN4_17760	COG4680	protein conserved in bacteria
AhaeAN4_17790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AhaeAN4_17795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AhaeAN4_17830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AhaeAN4_17840	COG0402	S-adenosylhomocysteine deaminase activity
AhaeAN4_17870	COG4680	protein conserved in bacteria
AhaeAN4_17875	COG1373	ATPase (AAA superfamily
AhaeAN4_17910	COG0789	Transcriptional regulator
AhaeAN4_18010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AhaeAN4_18055	COG2337	Toxic component of a toxin-antitoxin (TA) module
AhaeAN4_18060	COG2336	PFAM SpoVT AbrB