locus-tag	class	description
FK537_00095	COG2801	Transposase and inactivated derivatives
FK537_00100	COG0154	amidase activity
FK537_00105	COG2801	Transposase and inactivated derivatives
FK537_00155	COG3451	type IV secretory pathway VirB4
FK537_00175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FK537_00230	COG1192	Involved in chromosome partitioning
FK537_00265	COG4974	Belongs to the 'phage' integrase family
FK537_00300	COG3421	Type III restriction
FK537_00305	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FK537_00435	COG2801	Transposase and inactivated derivatives
FK537_00530	COG0596	Alpha beta hydrolase
FK537_00565	COG0511	ligase activity, forming carbon-carbon bonds
FK537_00585	COG2814	Major facilitator Superfamily
FK537_00620	COG1546	Belongs to the CinA family
FK537_00620	COG1058	Belongs to the CinA family
FK537_00630	COG0372	Belongs to the citrate synthase family
FK537_00650	COG0477	Major facilitator Superfamily
FK537_00665	COG0542	response to heat
FK537_00670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FK537_00690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FK537_00700	COG0569	domain protein
FK537_00705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FK537_00725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK537_00735	COG1585	Membrane protein implicated in regulation of membrane protease activity
FK537_00750	COG1294	oxidase, subunit
FK537_00755	COG4890	Cyd operon protein YbgT
FK537_00790	COG1960	acyl-CoA dehydrogenase activity
FK537_00795	COG1960	acyl-CoA dehydrogenase activity
FK537_00805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK537_00810	COG2207	Transcriptional regulator
FK537_00815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK537_00820	COG0730	response to heat
FK537_00825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK537_00855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK537_00890	COG0575	Belongs to the CDS family
FK537_00895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK537_00900	COG0233	cytoplasmic translational termination
FK537_00915	COG3852	Histidine kinase
FK537_00920	COG2204	response regulator
FK537_00930	COG0583	DNA-binding transcription factor activity
FK537_00960	COG3385	transposase activity
FK537_00965	COG1253	flavin adenine dinucleotide binding
FK537_00985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FK537_00990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FK537_01005	COG2431	L-lysine efflux transmembrane transporter activity
FK537_01010	COG0284	orotidine-5'-phosphate decarboxylase activity
FK537_01020	COG0776	regulation of translation
FK537_01050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FK537_01085	COG0084	hydrolase, TatD family'
FK537_01105	COG1663	tetraacyldisaccharide 4'-kinase activity
FK537_01110	COG1132	(ABC) transporter
FK537_01120	COG0811	peptide transport
FK537_01125	COG1475	DNA binding
FK537_01130	COG1192	Involved in chromosome partitioning
FK537_01140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FK537_01145	COG3178	'Phosphotransferase
FK537_01155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK537_01160	COG1923	regulation of RNA biosynthetic process
FK537_01170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FK537_01175	COG0802	atpase or kinase
FK537_01200	COG2707	UPF0756 membrane protein
FK537_01210	COG0583	DNA-binding transcription factor activity
FK537_01215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK537_01245	COG0519	Catalyzes the synthesis of GMP from XMP
FK537_01245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK537_01250	COG2353	YceI-like domain
FK537_01260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FK537_01265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FK537_01305	COG1254	Belongs to the acylphosphatase family
FK537_01310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FK537_01310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FK537_01315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FK537_01335	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_01345	COG3327	negative regulation of DNA-templated transcription, initiation
FK537_01350	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FK537_01355	COG0183	Belongs to the thiolase family
FK537_01360	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK537_01365	COG1024	Enoyl-CoA hydratase
FK537_01370	COG1024	Enoyl-CoA hydratase
FK537_01375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK537_01380	COG2151	metal-sulfur cluster biosynthetic enzyme
FK537_01385	COG3396	Phenylacetate-CoA oxygenase
FK537_01390	COG3460	Phenylacetate-CoA oxygenase
FK537_01395	COG3396	Phenylacetate-CoA oxygenase
FK537_01400	COG1012	belongs to the aldehyde dehydrogenase family
FK537_01400	COG2030	dehydratase
FK537_01405	COG2814	Major facilitator Superfamily
FK537_01410	COG0783	Belongs to the Dps family
FK537_01425	COG5002	protein histidine kinase activity
FK537_01425	COG5001	Diguanylate cyclase
FK537_01435	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
FK537_01455	COG4773	Receptor
FK537_01490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FK537_01525	COG0642	Histidine kinase
FK537_01540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FK537_01565	COG2816	NAD+ diphosphatase activity
FK537_01570	COG3046	protein related to deoxyribodipyrimidine photolyase
FK537_01585	COG2351	hydroxyisourate hydrolase activity
FK537_01620	COG1136	(ABC) transporter
FK537_01630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_01650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK537_01655	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_01695	COG2986	histidine ammonia-lyase
FK537_01710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK537_01720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK537_01725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK537_01835	COG0582	viral genome integration into host DNA
FK537_01875	COG1136	(ABC) transporter
FK537_01895	COG4245	von Willebrand factor, type A
FK537_01940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FK537_02075	COG0204	Acyl-transferase
FK537_02100	COG0012	GTP binding
FK537_02110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FK537_02125	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FK537_02135	COG0386	Belongs to the glutathione peroxidase family
FK537_02140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK537_02145	COG0436	Aminotransferase
FK537_02150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FK537_02150	COG2755	lipolytic protein G-D-S-L family
FK537_02190	COG2815	serine threonine protein kinase
FK537_02190	COG0515	serine threonine protein kinase
FK537_02230	COG1610	YqeY-like protein
FK537_02245	COG4783	chaperone-mediated protein folding
FK537_02310	COG0513	Belongs to the DEAD box helicase family
FK537_02330	COG2363	Small membrane protein
FK537_02350	COG0659	secondary active sulfate transmembrane transporter activity
FK537_02360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK537_02380	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_02385	COG1309	transcriptional regulator
FK537_02390	COG1960	acyl-CoA dehydrogenase activity
FK537_02395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK537_02400	COG1024	Enoyl-CoA hydratase
FK537_02405	COG4770	biotin carboxylase activity
FK537_02420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK537_02435	COG0540	Belongs to the ATCase OTCase family
FK537_02460	COG1765	OsmC-like protein
FK537_02470	COG0667	Aldo Keto reductase
FK537_02485	COG0501	Belongs to the peptidase M48B family
FK537_02490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FK537_02505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FK537_02515	COG0527	aspartate kinase activity
FK537_02525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FK537_02535	COG1215	transferase activity, transferring glycosyl groups
FK537_02545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FK537_02550	COG2252	PERMEase
FK537_02580	COG0714	Associated with various cellular activities
FK537_02585	COG2879	small protein
FK537_02590	COG1966	Carbon starvation protein
FK537_02595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FK537_02600	COG1509	lysine 2,3-aminomutase activity
FK537_02635	COG1067	ATP-dependent peptidase activity
FK537_02640	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FK537_02645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK537_02650	COG0583	DNA-binding transcription factor activity
FK537_02660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FK537_02675	COG1686	Belongs to the peptidase S11 family
FK537_02680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK537_02735	COG0616	signal peptide processing
FK537_02740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FK537_02750	COG0573	inorganic phosphate transmembrane transporter activity
FK537_02760	COG0076	glutamate decarboxylase activity
FK537_02765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FK537_02775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FK537_02785	COG2814	Major facilitator Superfamily
FK537_02790	COG1733	regulation of RNA biosynthetic process
FK537_02795	COG0702	epimerase
FK537_02825	COG0556	nucleotide-excision repair
FK537_02845	COG0436	Aminotransferase
FK537_02870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK537_02875	COG1381	Involved in DNA repair and RecF pathway recombination
FK537_02885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FK537_02890	COG0571	ribonuclease III activity
FK537_02900	COG0681	Belongs to the peptidase S26 family
FK537_02915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK537_02925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK537_02940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FK537_02950	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK537_02965	COG4208	sulfate ABC transporter
FK537_02970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FK537_02975	COG0583	DNA-binding transcription factor activity
FK537_02995	COG0602	queuosine metabolic process
FK537_03000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FK537_03010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK537_03015	COG2353	YceI-like domain
FK537_03020	COG1056	cytidyltransferase-related domain
FK537_03020	COG1051	belongs to the nudix hydrolase family
FK537_03025	COG1024	Enoyl-CoA hydratase
FK537_03030	COG0778	Nitroreductase
FK537_03045	COG0047	phosphoribosylformylglycinamidine synthase activity
FK537_03045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FK537_03070	COG2310	stress, protein
FK537_03100	COG1358	cellular component organization or biogenesis
FK537_03130	COG2255	four-way junction helicase activity
FK537_03140	COG0824	Thioesterase
FK537_03160	COG0823	Involved in the tonB-independent uptake of proteins
FK537_03180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK537_03210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK537_03215	COG0628	permease
FK537_03220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FK537_03225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FK537_03245	COG2333	competence protein COMEC
FK537_03245	COG0658	competence protein
FK537_03250	COG1136	(ABC) transporter
FK537_03255	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK537_03270	COG1671	Belongs to the UPF0178 family
FK537_03315	COG1280	lysine exporter protein (LysE YggA)
FK537_03320	COG1522	sequence-specific DNA binding
FK537_03330	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FK537_03345	COG0019	diaminopimelate decarboxylase activity
FK537_03355	COG1113	amino acid transport
FK537_03360	COG1115	amino acid carrier protein
FK537_03380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FK537_03385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FK537_03420	COG0583	DNA-binding transcription factor activity
FK537_03430	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FK537_03440	COG0174	glutamine synthetase
FK537_03445	COG0512	Glutamine amidotransferase of anthranilate synthase
FK537_03475	COG3706	GGDEF domain
FK537_03490	COG3739	integral membrane protein
FK537_03495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FK537_03505	COG1741	Belongs to the pirin family
FK537_03510	COG3842	ATPase activity
FK537_03515	COG1840	ABC-type Fe3 transport system, periplasmic component
FK537_03535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK537_03540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FK537_03550	COG0037	tRNA processing
FK537_03555	COG0739	heme binding
FK537_03555	COG0741	lytic transglycosylase activity
FK537_03555	COG1196	nuclear chromosome segregation
FK537_03560	COG0501	Belongs to the peptidase M48B family
FK537_03570	COG2239	Acts as a magnesium transporter
FK537_03605	COG1597	lipid kinase activity
FK537_03625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FK537_03660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK537_03670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK537_03680	COG1534	Rna-binding protein
FK537_03695	COG0505	Belongs to the CarA family
FK537_03710	COG1309	transcriptional regulator
FK537_03715	COG0251	oxidation-reduction process
FK537_03720	COG0110	maltose O-acetyltransferase activity
FK537_03725	COG0589	response to stress
FK537_03735	COG2321	neutral zinc metallopeptidase
FK537_03740	COG2354	Protein conserved in bacteria
FK537_03755	COG2268	Band 7 protein
FK537_03760	COG3658	cytochrome
FK537_03765	COG1215	transferase activity, transferring glycosyl groups
FK537_03770	COG0726	polysaccharide deacetylase
FK537_03770	COG1649	PFAM Uncharacterised BCR, COG1649
FK537_03780	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK537_03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK537_03805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK537_03810	COG1053	succinate dehydrogenase
FK537_03815	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FK537_03845	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FK537_03860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK537_03860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FK537_03890	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK537_03900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FK537_03930	COG0564	pseudouridine synthase activity
FK537_03940	COG0358	DNA primase activity
FK537_03955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FK537_03985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK537_04025	COG0586	Pfam SNARE associated Golgi protein
FK537_04060	COG0321	lipoyl(octanoyl) transferase activity
FK537_04080	COG0531	amino acid
FK537_04085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FK537_04090	COG1648	precorrin-2 dehydrogenase activity
FK537_04090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FK537_04095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FK537_04105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FK537_04130	COG0671	phosphoesterase, PA-phosphatase related
FK537_04135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_04145	COG1538	Outer membrane efflux protein
FK537_04150	COG0393	Putative heavy-metal-binding
FK537_04155	COG0393	Putative heavy-metal-binding
FK537_04170	COG0525	valine-tRNA ligase activity
FK537_04180	COG2852	Protein conserved in bacteria
FK537_04215	COG3328	transposase activity
FK537_04225	COG2323	membrane
FK537_04240	COG0765	amino acid transport
FK537_04245	COG0765	amino acid transport
FK537_04250	COG1126	abc transporter atp-binding protein
FK537_04255	COG3338	carbonate dehydratase activity
FK537_04270	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK537_04285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK537_04290	COG2205	protein histidine kinase activity
FK537_04295	COG0745	RESPONSE REGULATOR receiver
FK537_04310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK537_04315	COG1652	LysM domain
FK537_04325	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_04340	COG1399	metal-binding, possibly nucleic acid-binding protein
FK537_04345	COG3101	peptidyl-lysine hydroxylation
FK537_04350	COG0009	L-threonylcarbamoyladenylate synthase
FK537_04360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FK537_04365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FK537_04380	COG4106	trans-aconitate 2-methyltransferase activity
FK537_04395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_04395	COG0596	Alpha beta hydrolase
FK537_04395	COG2226	methyltransferase
FK537_04400	COG2193	ferroxidase activity
FK537_04405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK537_04410	COG3115	cell septum assembly
FK537_04415	COG1196	nuclear chromosome segregation
FK537_04425	COG0730	response to heat
FK537_04445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK537_04465	COG2801	Transposase and inactivated derivatives
FK537_04505	COG0628	permease
FK537_04515	COG2824	Alkylphosphonate utilization operon protein PhnA
FK537_04520	COG3189	MarR family transcriptional regulator
FK537_04535	COG0564	pseudouridine synthase activity
FK537_04570	COG0354	folic acid binding
FK537_04600	COG0363	glucosamine-6-phosphate deaminase activity
FK537_04610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FK537_04615	COG1877	trehalose-phosphatase activity
FK537_04625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK537_04630	COG1970	mechanosensitive ion channel activity
FK537_04640	COG2233	PERMEase
FK537_04650	COG0833	amino acid
FK537_04670	COG0183	Belongs to the thiolase family
FK537_04685	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_04695	COG2207	Transcriptional regulator
FK537_04700	COG0183	Belongs to the thiolase family
FK537_04705	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK537_04705	COG1024	Enoyl-CoA hydratase
FK537_04725	COG1272	protein, Hemolysin III
FK537_04730	COG0477	Major facilitator Superfamily
FK537_04740	COG1408	metallophosphoesterase
FK537_04745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK537_04755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FK537_04785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FK537_04790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK537_04795	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FK537_04805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FK537_04810	COG0625	glutathione transferase activity
FK537_04815	COG2969	positive regulation of protein catabolic process
FK537_04870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK537_04915	COG0037	tRNA processing
FK537_04925	COG0248	Ppx GppA phosphatase
FK537_04950	COG0072	phenylalanine-tRNA ligase activity
FK537_04985	COG1238	metal cluster binding
FK537_04990	COG0625	glutathione transferase activity
FK537_05000	COG0675	Transposase, IS605 OrfB family
FK537_05020	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_05025	COG3028	Belongs to the UPF0307 family
FK537_05035	COG1660	Displays ATPase and GTPase activities
FK537_05050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FK537_05055	COG0617	tRNA 3'-terminal CCA addition
FK537_05060	COG1555	photosystem II stabilization
FK537_05065	COG3956	TIGRFAM MazG family protein
FK537_05080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK537_05090	COG0124	histidyl-tRNA synthetase
FK537_05120	COG2975	iron-sulfur cluster assembly
FK537_05160	COG0440	acetolactate synthase activity
FK537_05165	COG0028	Belongs to the TPP enzyme family
FK537_05190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_05195	COG0577	efflux transmembrane transporter activity
FK537_05195	COG1136	(ABC) transporter
FK537_05265	COG4372	Transposase
FK537_05315	COG4372	Transposase
FK537_05340	COG3501	Rhs element vgr protein
FK537_05355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FK537_05360	COG1162	GTPase activity
FK537_05370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FK537_05380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FK537_05390	COG3781	membrane
FK537_05395	COG0613	PHP domain protein
FK537_05405	COG2350	Protein conserved in bacteria
FK537_05425	COG1666	GTP binding
FK537_05435	COG1607	acyl-coa hydrolase
FK537_05500	COG1183	phosphatidylcholine synthase activity
FK537_05505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FK537_05545	COG1196	nuclear chromosome segregation
FK537_05545	COG0741	lytic transglycosylase activity
FK537_05545	COG0739	heme binding
FK537_05555	COG1702	phosphate starvation-inducible protein PhoH
FK537_05615	COG1295	ribonuclease BN
FK537_05630	COG4372	Transposase
FK537_05660	COG0788	formyltetrahydrofolate deformylase activity
FK537_05685	COG4651	solute:proton antiporter activity
FK537_05685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK537_05700	COG0724	RNA recognition motif
FK537_05705	COG0210	DNA helicase
FK537_05715	COG1929	Belongs to the glycerate kinase type-1 family
FK537_05745	COG2900	Belongs to the SlyX family
FK537_05755	COG1560	Kdo2-lipid A biosynthetic process
FK537_05810	COG0473	3-isopropylmalate dehydrogenase activity
FK537_05825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FK537_05840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK537_05855	COG0494	nUDIX hydrolase
FK537_05875	COG1960	acyl-CoA dehydrogenase activity
FK537_05885	COG0753	catalase activity
FK537_05900	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK537_05905	COG3384	dioxygenase
FK537_05910	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_05925	COG4638	Rieske (2fe-2S)
FK537_05930	COG0583	DNA-binding transcription factor activity
FK537_05955	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FK537_05960	COG3971	2-oxopent-4-enoate hydratase activity
FK537_05965	COG0546	phosphoglycolate phosphatase activity
FK537_05980	COG1530	ribonuclease E activity
FK537_05985	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_06020	COG1983	PspC domain protein
FK537_06025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK537_06025	COG0617	tRNA 3'-terminal CCA addition
FK537_06025	COG0517	IMP dehydrogenase activity
FK537_06035	COG0751	glycine-tRNA ligase activity
FK537_06060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK537_06085	COG0493	'glutamate synthase
FK537_06085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK537_06095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FK537_06105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK537_06120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK537_06130	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FK537_06130	COG0644	oxidoreductase
FK537_06365	COG3501	Rhs element vgr protein
FK537_06370	COG0425	Belongs to the sulfur carrier protein TusA family
FK537_06375	COG4535	Mg2 and Co2 transporter CorC
FK537_06380	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FK537_06400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FK537_06410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FK537_06420	COG0789	Transcriptional regulator
FK537_06425	COG2841	Protein conserved in bacteria
FK537_06440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FK537_06450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK537_06455	COG1074	ATP-dependent DNA helicase activity
FK537_06460	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FK537_06490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK537_06500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FK537_06515	COG2111	Na H antiporter
FK537_06515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK537_06520	COG1006	Multisubunit Na H antiporter MnhC subunit
FK537_06525	COG0651	ATP synthesis coupled electron transport
FK537_06535	COG2212	antiporter activity
FK537_06545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FK537_06555	COG0195	Participates in both transcription termination and antitermination
FK537_06560	COG0779	Required for maturation of 30S ribosomal subunits
FK537_06610	COG0237	dephospho-CoA kinase activity
FK537_06620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK537_06625	COG3123	guanosine phosphorylase activity
FK537_06630	COG0497	DNA recombination
FK537_06640	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FK537_06655	COG1132	(ABC) transporter
FK537_06660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FK537_06690	COG1024	Enoyl-CoA hydratase
FK537_06690	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK537_06700	COG2233	PERMEase
FK537_06710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FK537_06735	COG0326	Molecular chaperone. Has ATPase activity
FK537_06755	COG2056	Na+-H+ antiporter family
FK537_06775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FK537_06780	COG0085	RNA polymerase activity
FK537_06795	COG0081	regulation of translation
FK537_06880	COG0824	Thioesterase
FK537_06900	COG0181	hydroxymethylbilane synthase activity
FK537_06910	COG3275	phosphorelay sensor kinase activity
FK537_06945	COG0494	nUDIX hydrolase
FK537_06950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FK537_06955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FK537_06960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK537_06970	COG0772	Belongs to the SEDS family
FK537_06995	COG4974	Belongs to the 'phage' integrase family
FK537_07010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FK537_07020	COG2197	response regulator
FK537_07035	COG0793	Belongs to the peptidase S41A family
FK537_07040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK537_07045	COG0795	lipopolysaccharide-transporting ATPase activity
FK537_07050	COG0795	lipopolysaccharide-transporting ATPase activity
FK537_07075	COG0586	Pfam SNARE associated Golgi protein
FK537_07090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK537_07090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK537_07100	COG0004	ammonium transporteR
FK537_07105	COG0347	Belongs to the P(II) protein family
FK537_07115	COG0606	chelatase, subunit chli
FK537_07130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK537_07145	COG0318	PFAM AMP-dependent synthetase and ligase
FK537_07155	COG0477	Major facilitator Superfamily
FK537_07160	COG2860	membrane
FK537_07170	COG1253	flavin adenine dinucleotide binding
FK537_07190	COG2814	Major facilitator Superfamily
FK537_07205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK537_07230	COG2814	Major facilitator Superfamily
FK537_07280	COG0758	DNA mediated transformation
FK537_07295	COG0697	spore germination
FK537_07300	COG0386	Belongs to the glutathione peroxidase family
FK537_07325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FK537_07375	COG1121	(ABC) transporter
FK537_07380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FK537_07390	COG2837	iron assimilation
FK537_07445	COG3501	Rhs element vgr protein
FK537_07450	COG0281	malic enzyme
FK537_07490	COG1715	Restriction endonuclease
FK537_07495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK537_07495	COG0519	Catalyzes the synthesis of GMP from XMP
FK537_07500	COG2259	Doxx family
FK537_07505	COG0586	Pfam SNARE associated Golgi protein
FK537_07520	COG1192	Involved in chromosome partitioning
FK537_07530	COG0271	Belongs to the BolA IbaG family
FK537_07565	COG3756	Protein conserved in bacteria
FK537_07645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FK537_07650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK537_07665	COG1570	exodeoxyribonuclease VII activity
FK537_07750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FK537_07765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FK537_07775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FK537_07785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK537_07800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FK537_07810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK537_07820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FK537_07840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FK537_07845	COG1215	transferase activity, transferring glycosyl groups
FK537_07850	COG0463	Glycosyl transferase, family 2
FK537_07855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FK537_07860	COG2244	polysaccharide biosynthetic process
FK537_07890	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FK537_07950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_07955	COG1309	transcriptional regulator
FK537_07965	COG2233	PERMEase
FK537_07990	COG0129	dihydroxy-acid dehydratase activity
FK537_08010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FK537_08020	COG0733	neurotransmitter:sodium symporter activity
FK537_08025	COG1012	belongs to the aldehyde dehydrogenase family
FK537_08035	COG2814	Major facilitator Superfamily
FK537_08065	COG0737	Belongs to the 5'-nucleotidase family
FK537_08090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FK537_08095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FK537_08120	COG0488	(ABC) transporter
FK537_08125	COG1063	alcohol dehydrogenase
FK537_08130	COG0187	DNA topoisomerase II activity
FK537_08140	COG0592	DNA-directed DNA polymerase activity
FK537_08145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK537_08155	COG0594	ribonuclease P activity
FK537_08160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FK537_08165	COG0706	membrane insertase activity
FK537_08200	COG1230	cation diffusion facilitator family transporter
FK537_08205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FK537_08220	COG0402	S-adenosylhomocysteine deaminase activity
FK537_08225	COG0861	Integral membrane protein TerC family
FK537_08235	COG2388	GCN5-related N-acetyl-transferase
FK537_08245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK537_08265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FK537_08275	COG2951	lytic endotransglycosylase activity
FK537_08320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK537_08350	COG2814	Major facilitator Superfamily
FK537_08355	COG2133	pyrroloquinoline quinone binding
FK537_08365	COG1047	Peptidyl-prolyl cis-trans
FK537_08370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK537_08375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FK537_08380	COG0196	riboflavin kinase activity
FK537_08390	COG1309	transcriptional regulator
FK537_08405	COG1116	anion transmembrane transporter activity
FK537_08410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FK537_08415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK537_08420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK537_08425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK537_08450	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_08455	COG0546	phosphoglycolate phosphatase activity
FK537_08460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK537_08470	COG1309	transcriptional regulator
FK537_08475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FK537_08485	COG3023	N-Acetylmuramoyl-L-alanine amidase
FK537_08505	COG1064	alcohol dehydrogenase
FK537_08510	COG2818	Glycosylase
FK537_08520	COG0739	heme binding
FK537_08525	COG1194	a g-specific adenine glycosylase
FK537_08540	COG5487	UPF0391 membrane protein
FK537_08545	COG2983	Belongs to the UPF0260 family
FK537_08550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FK537_08555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FK537_08565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FK537_08570	COG2814	Major facilitator Superfamily
FK537_08575	COG1335	isochorismatase
FK537_08580	COG0385	Bile acid
FK537_08595	COG3830	Belongs to the UPF0237 family
FK537_08595	COG0560	Phosphoserine phosphatase
FK537_08615	COG0753	catalase activity
FK537_08670	COG2175	clavaminate synthase activity
FK537_08675	COG0534	Mate efflux family protein
FK537_08680	COG0436	Aminotransferase
FK537_08685	COG2733	membrane
FK537_08700	COG2918	glutathione biosynthetic process
FK537_08705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FK537_08715	COG3150	esterase
FK537_08755	COG0471	metal ion transport
FK537_08770	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FK537_08775	COG4266	Belongs to the allantoicase family
FK537_08780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK537_08785	COG1247	-acetyltransferase
FK537_08825	COG0625	glutathione transferase activity
FK537_08830	COG3706	GGDEF domain
FK537_08835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FK537_08850	COG1393	Belongs to the ArsC family
FK537_08855	COG0708	Exodeoxyribonuclease III
FK537_08900	COG4115	mRNA cleavage
FK537_08910	COG0189	ligase activity
FK537_08915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK537_08920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK537_08930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FK537_08940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FK537_08970	COG2119	membrane
FK537_08975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK537_08975	COG0426	domain, Protein
FK537_09000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FK537_09020	COG1902	pentaerythritol trinitrate reductase activity
FK537_09025	COG1519	Transferase
FK537_09030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK537_09035	COG0668	transmembrane transport
FK537_09040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK537_09055	COG0431	NADPH-dependent FMN reductase
FK537_09070	COG0784	Response regulator, receiver
FK537_09070	COG2205	protein histidine kinase activity
FK537_09075	COG3162	membrane
FK537_09080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK537_09100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK537_09110	COG3706	GGDEF domain
FK537_09115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK537_09120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK537_09130	COG2814	Major facilitator Superfamily
FK537_09135	COG0629	single-stranded DNA binding
FK537_09150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FK537_09175	COG3158	transport of potassium into the cell
FK537_09215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FK537_09230	COG0697	spore germination
FK537_09255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FK537_09285	COG0427	acetyl-CoA hydrolase
FK537_09290	COG2205	protein histidine kinase activity
FK537_09295	COG0745	RESPONSE REGULATOR receiver
FK537_09310	COG4221	oxidoreductase activity
FK537_09320	COG0488	(ABC) transporter
FK537_09340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK537_09350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK537_09355	COG0275	rRNA processing
FK537_09370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK537_09375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FK537_09385	COG2226	methyltransferase
FK537_09435	COG0069	glutamate synthase activity
FK537_09435	COG0067	glutamate synthase
FK537_09435	COG0070	glutamate synthase
FK537_09440	COG0493	'glutamate synthase
FK537_09450	COG1704	LemA family
FK537_09455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK537_09475	COG3307	-O-antigen
FK537_09495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK537_09500	COG1758	RNA polymerase activity
FK537_09505	COG0194	GDP metabolic process
FK537_09550	COG0228	four-way junction DNA binding
FK537_09555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FK537_09565	COG0335	large ribosomal subunit rRNA binding
FK537_09575	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FK537_09580	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FK537_09585	COG5380	lipid catabolic process
FK537_09590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FK537_09615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FK537_09620	COG0277	FAD linked oxidase domain protein
FK537_09635	COG2814	Major facilitator Superfamily
FK537_09645	COG0628	permease
FK537_09650	COG1192	Involved in chromosome partitioning
FK537_09665	COG2226	methyltransferase
FK537_09685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FK537_09690	COG0254	rRNA binding
FK537_09695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK537_09700	COG0534	Mate efflux family protein
FK537_09710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK537_09715	COG1960	acyl-CoA dehydrogenase activity
FK537_09735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK537_09760	COG1127	ABC transporter
FK537_09765	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK537_09770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FK537_09775	COG2854	intermembrane phospholipid transfer
FK537_09785	COG0598	Magnesium transport protein CorA
FK537_09800	COG1040	competence protein
FK537_09805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK537_09815	COG2937	Belongs to the GPAT DAPAT family
FK537_09820	COG1946	Acyl-CoA thioesterase
FK537_09825	COG1301	dicarboxylic acid transport
FK537_09855	COG1959	2 iron, 2 sulfur cluster binding
FK537_09865	COG0433	COG0433 Predicted ATPase
FK537_09895	COG0088	Forms part of the polypeptide exit tunnel
FK537_09925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FK537_09960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FK537_09965	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FK537_09975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FK537_10010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FK537_10015	COG0202	RNA polymerase activity
FK537_10025	COG2072	flavoprotein involved in K transport
FK537_10030	COG1960	acyl-CoA dehydrogenase activity
FK537_10035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FK537_10055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FK537_10060	COG0697	spore germination
FK537_10070	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FK537_10075	COG0339	signal peptide processing
FK537_10080	COG0557	exoribonuclease II activity
FK537_10115	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK537_10145	COG3040	lipid binding
FK537_10205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_10205	COG2813	Specifically methylates the guanine in position
FK537_10210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_10215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FK537_10225	COG3128	pkhd-type hydroxylase
FK537_10230	COG4774	siderophore transport
FK537_10235	COG4771	TonB-dependent receptor
FK537_10245	COG0740	serine-type endopeptidase activity
FK537_10275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FK537_10275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FK537_10300	COG0857	belongs to the CobB CobQ family
FK537_10300	COG0280	phosphate acetyltransferase
FK537_10305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FK537_10335	COG0793	Belongs to the peptidase S41A family
FK537_10385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FK537_10400	COG0084	hydrolase, TatD family'
FK537_10405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FK537_10410	COG3385	transposase activity
FK537_10415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK537_10435	COG1546	Belongs to the CinA family
FK537_10435	COG1058	Belongs to the CinA family
FK537_10455	COG2814	Major facilitator Superfamily
FK537_10460	COG0697	spore germination
FK537_10485	COG3622	Belongs to the hyi family
FK537_10495	COG1024	Enoyl-CoA hydratase
FK537_10500	COG2205	protein histidine kinase activity
FK537_10500	COG5002	protein histidine kinase activity
FK537_10500	COG0784	Response regulator, receiver
FK537_10505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK537_10520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK537_10540	COG1862	Preprotein translocase
FK537_10555	COG1704	LemA family
FK537_10565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FK537_10580	COG3385	transposase activity
FK537_10585	COG5002	protein histidine kinase activity
FK537_10590	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FK537_10645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FK537_10695	COG3385	transposase activity
FK537_10705	COG1960	acyl-CoA dehydrogenase activity
FK537_10710	COG1960	acyl-CoA dehydrogenase activity
FK537_10720	COG2205	protein histidine kinase activity
FK537_10725	COG0745	RESPONSE REGULATOR receiver
FK537_10735	COG2315	Protein conserved in bacteria
FK537_10740	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FK537_10745	COG3385	transposase activity
FK537_10765	COG2096	Adenosyltransferase
FK537_10770	COG4206	TonB-dependent receptor
FK537_10815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FK537_10820	COG0285	dihydrofolate synthase activity
FK537_10835	COG0450	alkyl hydroperoxide reductase
FK537_10855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FK537_10860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FK537_10890	COG2199	diguanylate cyclase activity
FK537_10950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FK537_10955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FK537_11005	COG0494	nUDIX hydrolase
FK537_11015	COG1214	PFAM Peptidase M22, glycoprotease
FK537_11020	COG1968	undecaprenyl-diphosphatase activity
FK537_11040	COG4269	membrane
FK537_11055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK537_11065	COG2132	Multicopper oxidase
FK537_11075	COG2076	Multidrug Resistance protein
FK537_11080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FK537_11095	COG0351	phosphomethylpyrimidine kinase
FK537_11095	COG0352	thiamine-phosphate diphosphorylase activity
FK537_11095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK537_11120	COG0251	oxidation-reduction process
FK537_11125	COG1113	amino acid transport
FK537_11145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FK537_11170	COG0456	acetyltransferase
FK537_11180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FK537_11185	COG0492	ferredoxin-NADP+ reductase activity
FK537_11190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK537_11190	COG1674	ftsk spoiiie
FK537_11205	COG2894	cell division
FK537_11210	COG0850	regulation of cytokinetic process
FK537_11220	COG0204	Acyl-transferase
FK537_11225	COG2885	chlorophyll binding
FK537_11230	COG0210	DNA helicase
FK537_11240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK537_11255	COG0121	glutamine amidotransferase
FK537_11270	COG2914	Belongs to the UPF0125 (RnfH) family
FK537_11275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK537_11280	COG0735	belongs to the Fur family
FK537_11310	COG0420	3'-5' exonuclease activity
FK537_11330	COG2050	protein possibly involved in aromatic compounds catabolism
FK537_11335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FK537_11345	COG0582	viral genome integration into host DNA
FK537_11465	COG3177	Filamentation induced by cAMP protein fic
FK537_11520	COG0726	polysaccharide deacetylase
FK537_11520	COG1649	PFAM Uncharacterised BCR, COG1649
FK537_11525	COG1215	transferase activity, transferring glycosyl groups
FK537_11540	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FK537_11570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK537_11580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK537_11585	COG1077	Cell shape determining protein MreB Mrl
FK537_11590	COG1792	Involved in formation and maintenance of cell shape
FK537_11595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FK537_11600	COG0424	maF-like protein
FK537_11605	COG1530	ribonuclease E activity
FK537_11610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FK537_11650	COG0625	glutathione transferase activity
FK537_11675	COG1113	amino acid transport
FK537_11680	COG2828	Protein conserved in bacteria
FK537_11685	COG0142	geranyltranstransferase activity
FK537_11695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK537_11715	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FK537_11725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FK537_11730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK537_11735	COG0839	Belongs to the complex I subunit 6 family
FK537_11740	COG0713	ATP synthesis coupled electron transport
FK537_11745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK537_11750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK537_11765	COG1278	Cold shock
FK537_11770	COG1278	Cold shock
FK537_11775	COG0583	DNA-binding transcription factor activity
FK537_11800	COG0668	transmembrane transport
FK537_11810	COG2081	HI0933 family
FK537_11825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FK537_11840	COG0004	ammonium transporteR
FK537_11855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK537_11855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK537_11860	COG0489	protein tyrosine kinase activity
FK537_11875	COG2358	TRAP transporter, solute receptor (TAXI family
FK537_11910	COG0442	prolyl-tRNA aminoacylation
FK537_11945	COG0840	transmembrane signaling receptor activity
FK537_11950	COG2198	Histidine kinase
FK537_11950	COG0784	Response regulator, receiver
FK537_11950	COG0643	Histidine kinase
FK537_11965	COG5510	response to toxic substance
FK537_11975	COG2832	Protein of unknown function (DUF454)
FK537_11980	COG1376	ErfK ybiS ycfS ynhG family protein
FK537_12035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FK537_12045	COG1289	transmembrane transporter activity
FK537_12050	COG2814	Major facilitator Superfamily
FK537_12065	COG0786	glutamate:sodium symporter activity
FK537_12070	COG1115	amino acid carrier protein
FK537_12075	COG2059	Chromate
FK537_12080	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK537_12090	COG1607	acyl-coa hydrolase
FK537_12100	COG2814	Major facilitator Superfamily
FK537_12105	COG0583	DNA-binding transcription factor activity
FK537_12125	COG0523	cobalamin synthesis protein
FK537_12130	COG4681	YaeQ
FK537_12140	COG2199	diguanylate cyclase activity
FK537_12140	COG2203	Gaf domain
FK537_12170	COG0477	Major facilitator Superfamily
FK537_12180	COG2066	Belongs to the glutaminase family
FK537_12185	COG2376	Dihydroxyacetone kinase
FK537_12210	COG0306	phosphate transporter
FK537_12235	COG4771	TonB-dependent receptor
FK537_12260	COG4181	ATPase activity
FK537_12265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FK537_12275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK537_12285	COG0583	DNA-binding transcription factor activity
FK537_12295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_12300	COG1773	rubredoxin
FK537_12305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FK537_12340	COG3118	belongs to the thioredoxin family
FK537_12360	COG1253	flavin adenine dinucleotide binding
FK537_12380	COG3015	lipoprotein NlpE involved in copper resistance
FK537_12395	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_12415	COG0804	urea catabolic process
FK537_12430	COG0830	nickel cation binding
FK537_12435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FK537_12445	COG0742	ribosomal rna small subunit methyltransferase
FK537_12450	COG0768	penicillin binding
FK537_12475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FK537_12480	COG2878	Part of a membrane complex involved in electron transport
FK537_12485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FK537_12495	COG3384	dioxygenase
FK537_12505	COG2234	aminopeptidase activity
FK537_12515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FK537_12535	COG2186	Transcriptional regulator
FK537_12545	COG0277	FAD linked oxidase domain protein
FK537_12575	COG3079	Belongs to the UPF0149 family
FK537_12580	COG0006	proline dipeptidase activity
FK537_12590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK537_12595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK537_12630	COG2816	NAD+ diphosphatase activity
FK537_12645	COG1388	LysM domain
FK537_12645	COG0741	lytic transglycosylase activity
FK537_12650	COG4166	transmembrane transport
FK537_12655	COG4174	ABC transporter (Permease)
FK537_12660	COG4239	(ABC) transporter, permease
FK537_12665	COG4172	Belongs to the ABC transporter superfamily
FK537_12695	COG0833	amino acid
FK537_12715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK537_12720	COG0418	dihydroorotase activity
FK537_12725	COG5001	Diguanylate cyclase
FK537_12725	COG4251	negative regulation of phosphorylation
FK537_12725	COG3706	GGDEF domain
FK537_12725	COG2203	Gaf domain
FK537_12740	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK537_12740	COG1902	pentaerythritol trinitrate reductase activity
FK537_12760	COG2871	sodium ion transport
FK537_12790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FK537_12810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK537_12815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FK537_12820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FK537_12860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FK537_12870	COG2175	clavaminate synthase activity
FK537_12890	COG0052	Belongs to the universal ribosomal protein uS2 family
FK537_12915	COG2951	lytic endotransglycosylase activity
FK537_12930	COG0842	Transport permease protein
FK537_12935	COG1131	(ABC) transporter
FK537_12995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK537_13015	COG3634	alkyl hydroperoxide reductase activity
FK537_13020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK537_13035	COG0640	Transcriptional regulator
FK537_13045	COG0798	PFAM Bile acid sodium symporter
FK537_13050	COG0431	NADPH-dependent FMN reductase
FK537_13055	COG0789	Transcriptional regulator
FK537_13070	COG1720	tRNA m6t6A37 methyltransferase activity
FK537_13080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FK537_13090	COG0745	RESPONSE REGULATOR receiver
FK537_13095	COG0642	Histidine kinase
FK537_13115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK537_13120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FK537_13125	COG3139	Protein of unknown function (DUF1315)
FK537_13135	COG1301	dicarboxylic acid transport
FK537_13140	COG1960	acyl-CoA dehydrogenase activity
FK537_13145	COG0693	protein deglycase activity
FK537_13155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FK537_13160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FK537_13185	COG1047	Peptidyl-prolyl cis-trans
FK537_13190	COG1252	NADH dehydrogenase
FK537_13195	COG1686	Belongs to the peptidase S11 family
FK537_13210	COG1187	pseudouridine synthase activity
FK537_13220	COG0739	heme binding
FK537_13235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK537_13245	COG0612	Peptidase, M16
FK537_13280	COG0352	thiamine-phosphate diphosphorylase activity
FK537_13320	COG0596	Alpha beta hydrolase
FK537_13325	COG1309	transcriptional regulator
FK537_13345	COG2885	chlorophyll binding
FK537_13345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FK537_13385	COG0110	maltose O-acetyltransferase activity
FK537_13405	COG0438	transferase activity, transferring glycosyl groups
FK537_13440	COG1278	Cold shock
FK537_13455	COG2070	2-Nitropropane dioxygenase
FK537_13480	COG2391	methyltransferase activity
FK537_13490	COG3634	alkyl hydroperoxide reductase activity
FK537_13520	COG1643	Atp-dependent helicase
FK537_13545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK537_13545	COG0517	IMP dehydrogenase activity
FK537_13550	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FK537_13560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FK537_13565	COG1137	ATPase activity
FK537_13575	COG2274	protein secretion by the type I secretion system
FK537_13600	COG4122	O-methyltransferase activity
FK537_13610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FK537_13620	COG1454	alcohol dehydrogenase
FK537_13650	COG2011	ABC-type metal ion transport system permease component
FK537_13655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FK537_13675	COG0138	bifunctional purine biosynthesis protein purh
FK537_13680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FK537_13725	COG2308	Evidence 4 Homologs of previously reported genes of
FK537_13735	COG1305	Transglutaminase-like
FK537_13750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK537_13765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FK537_13770	COG0360	Binds together with S18 to 16S ribosomal RNA
FK537_13780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FK537_13785	COG1845	cytochrome c oxidase, subunit III
FK537_13790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK537_13795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FK537_13820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK537_13835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK537_13845	COG3781	membrane
FK537_13865	COG1960	acyl-CoA dehydrogenase activity
FK537_13870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK537_13880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FK537_13890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FK537_13910	COG0477	Major facilitator Superfamily
FK537_13955	COG0786	glutamate:sodium symporter activity
FK537_13985	COG0308	aminopeptidase N
FK537_13995	COG0589	response to stress
FK537_14000	COG0589	response to stress
FK537_14010	COG3135	benzoate transporter
FK537_14020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK537_14035	COG0183	Belongs to the thiolase family
FK537_14045	COG2030	dehydratase
FK537_14065	COG0824	Thioesterase
FK537_14070	COG1454	alcohol dehydrogenase
FK537_14075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FK537_14095	COG0069	glutamate synthase activity
FK537_14105	COG4585	Histidine kinase
FK537_14110	COG2850	peptidyl-arginine hydroxylation
FK537_14115	COG0424	maF-like protein
FK537_14140	COG0697	spore germination
FK537_14180	COG3698	Phosphodiester glycosidase
FK537_14200	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK537_14200	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK537_14200	COG0506	proline dehydrogenase activity
FK537_14210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK537_14215	COG1027	Aspartate ammonia-lyase
FK537_14220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FK537_14225	COG0583	DNA-binding transcription factor activity
FK537_14230	COG1960	acyl-CoA dehydrogenase activity
FK537_14250	COG1902	pentaerythritol trinitrate reductase activity
FK537_14250	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK537_14265	COG3385	transposase activity
FK537_14270	COG2814	Major facilitator Superfamily
FK537_14280	COG0583	DNA-binding transcription factor activity
FK537_14300	COG0148	phosphopyruvate hydratase activity
FK537_14315	COG0772	Belongs to the SEDS family
FK537_14330	COG2137	regulation of response to DNA damage stimulus
FK537_14340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FK537_14345	COG1011	Hydrolase
FK537_14365	COG0268	Binds directly to 16S ribosomal RNA
FK537_14370	COG0702	epimerase
FK537_14375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FK537_14390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FK537_14420	COG0316	Belongs to the HesB IscA family
FK537_14425	COG0822	iron-sulfur transferase activity
FK537_14455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK537_14510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FK537_14530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK537_14540	COG0133	tryptophan synthase activity
FK537_14545	COG3385	transposase activity
FK537_14550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK537_14550	COG0517	IMP dehydrogenase activity
FK537_14550	COG0617	tRNA 3'-terminal CCA addition
FK537_14580	COG0612	Peptidase, M16
FK537_14585	COG0552	protein localization to endoplasmic reticulum
FK537_14630	COG0693	protein deglycase activity
FK537_14640	COG1283	sodium-dependent phosphate transmembrane transporter activity
FK537_14650	COG1346	cytolysis
FK537_14660	COG0583	DNA-binding transcription factor activity
FK537_14680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FK537_14685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK537_14710	COG1960	acyl-CoA dehydrogenase activity
FK537_14715	COG1917	Cupin 2, conserved barrel domain protein
FK537_14715	COG2207	Transcriptional regulator
FK537_14720	COG2814	Major facilitator Superfamily
FK537_14730	COG1271	oxidase subunit
FK537_14735	COG1294	oxidase, subunit
FK537_14745	COG1525	nuclease
FK537_14795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK537_14800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FK537_14815	COG1113	amino acid transport
FK537_14825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK537_14835	COG2814	Major facilitator Superfamily
FK537_14855	COG1132	(ABC) transporter
FK537_14865	COG0668	transmembrane transport
FK537_14870	COG3122	Protein conserved in bacteria
FK537_14890	COG0640	Transcriptional regulator
FK537_14895	COG2937	Belongs to the GPAT DAPAT family
FK537_14900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK537_14905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK537_14905	COG1116	anion transmembrane transporter activity
FK537_14915	COG2223	nitrite transmembrane transporter activity
FK537_14920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_14925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK537_14930	COG0243	molybdopterin cofactor binding
FK537_14940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FK537_14955	COG0315	cyclic pyranopterin monophosphate synthase activity
FK537_14955	COG0521	Mo-molybdopterin cofactor biosynthetic process
FK537_14960	COG0303	'Molybdopterin
FK537_14970	COG4149	molybdate abc transporter
FK537_14975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FK537_14980	COG0583	DNA-binding transcription factor activity
FK537_15000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK537_15005	COG0183	Belongs to the thiolase family
FK537_15010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK537_15015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FK537_15020	COG3135	benzoate transporter
FK537_15025	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_15030	COG0543	2 iron, 2 sulfur cluster binding
FK537_15030	COG0633	Ferredoxin
FK537_15035	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FK537_15040	COG4638	Rieske (2fe-2S)
FK537_15050	COG4829	muconolactone delta-isomerase
FK537_15055	COG4948	Mandelate Racemase Muconate Lactonizing
FK537_15060	COG0583	DNA-binding transcription factor activity
FK537_15065	COG2814	Major facilitator Superfamily
FK537_15095	COG1028	Short-chain dehydrogenase reductase Sdr
FK537_15105	COG2223	nitrite transmembrane transporter activity
FK537_15115	COG0675	Transposase, IS605 OrfB family
FK537_15120	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
FK537_15125	COG2116	formate transmembrane transporter activity
FK537_15130	COG0515	serine threonine protein kinase
FK537_15145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK537_15180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK537_15185	COG1309	transcriptional regulator
FK537_15190	COG1012	belongs to the aldehyde dehydrogenase family
FK537_15210	COG0745	RESPONSE REGULATOR receiver
FK537_15220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK537_15245	COG2885	chlorophyll binding
FK537_15255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FK537_15260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK537_15265	COG0730	response to heat
FK537_15285	COG1309	transcriptional regulator
FK537_15305	COG3501	Rhs element vgr protein