locus-tag class description FHP22_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FHP22_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FHP22_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHP22_00040 ENOG4105E2A Dehydrogenase FHP22_00045 ENOG4105C5H ABC transporter FHP22_00050 ENOG4108821 RND type efflux pump FHP22_00060 ENOG4108821 RND type efflux pump FHP22_00070 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FHP22_00075 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FHP22_00085 ENOG4108RS6 transposase FHP22_00100 ENOG4105CGH 5'-nucleotidase FHP22_00130 ENOG4105D2S major facilitator superfamily FHP22_00145 ENOG4108RS6 transposase FHP22_00155 ENOG4105C26 Dehydrogenase FHP22_00170 ENOG4105C8J )-transporter FHP22_00180 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FHP22_00200 ENOG4105C01 Dihydroxy-acid dehydratase FHP22_00215 ENOG4105C2W permease FHP22_00225 ENOG4105J7D transcriptional regulator FHP22_00230 ENOG4105DJY efflux transporter, rnd family, mfp subunit FHP22_00265 ENOG4108MRJ FHP22_00270 ENOG4105D75 Capsular exopolysaccharide family FHP22_00280 ENOG4105DAY polysaccharide export protein FHP22_00290 ENOG4105C6Y Udp-glucose 6-dehydrogenase FHP22_00300 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FHP22_00310 ENOG4105D3Q Sugar transferase FHP22_00320 ENOG4105D3Q Sugar transferase FHP22_00325 ENOG4107WZ3 Transferase FHP22_00330 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FHP22_00340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FHP22_00345 ENOG4105C6Y Udp-glucose 6-dehydrogenase FHP22_00355 ENOG4105CMR udp-glucose 4-epimerase FHP22_00360 ENOG4107QKV phosphomannomutase FHP22_00405 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FHP22_00415 ENOG4108ZAI phosphatidylglycerophosphatase a FHP22_00420 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FHP22_00430 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FHP22_00435 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FHP22_00475 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FHP22_00495 ENOG4105CHH sulfate transporter FHP22_00510 ENOG4107Z6W Protein CrcB homolog FHP22_00540 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FHP22_00555 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FHP22_00560 ENOG4105KT5 UmuD protein FHP22_00565 ENOG4105DIJ Phosphoethanolamine transferase FHP22_00570 ENOG4105XJC Two component transcriptional regulator (Winged helix family FHP22_00575 ENOG4105DHQ Histidine kinase FHP22_00585 ENOG41080IJ Diacylglycerol kinase FHP22_00655 ENOG4108HFV FHP22_00675 ENOG4105ZTP Protein of unknown function (DUF1376) FHP22_00710 ENOG4105M85 Bola protein FHP22_00720 ENOG4107QJE Chromosome Partitioning Protein FHP22_00735 ENOG4105DQR SNARE associated Golgi FHP22_00740 ENOG4108VBZ doxx family FHP22_00745 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FHP22_00750 ENOG4105BZU Histidine kinase FHP22_00755 ENOG4105EUB pirin domain protein FHP22_00785 ENOG4107R1I NAD-dependent malic enzyme FHP22_00790 ENOG4105CS6 Rhs element vgr protein FHP22_00795 ENOG4105NVB glycoside hydrolase, family 19 FHP22_00835 ENOG4105EZR dyp-type peroxidase family protein FHP22_00840 ENOG410829K Lysine exporter protein (Lyse ygga) FHP22_00845 ENOG4105FAV ABC, transporter FHP22_00850 ENOG4105FDK ABC transporter FHP22_00875 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FHP22_00890 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FHP22_00900 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FHP22_00910 ENOG41090VV Protein of unknown function (DUF2846) FHP22_00915 ENOG4105EUB pirin domain protein FHP22_00925 ENOG4108V06 Glutathione peroxidase FHP22_00945 ENOG4105C79 DNA protecting protein DprA FHP22_00995 ENOG4105D94 Major Facilitator Superfamily FHP22_01000 ENOG4105CCT upf0313 protein FHP22_01020 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FHP22_01035 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHP22_01050 ENOG4108URH decarboxylase FHP22_01055 ENOG4105EE5 Membrane protein terC FHP22_01060 ENOG4105K5B UPF0225 protein FHP22_01065 ENOG4105EN6 Membrane FHP22_01070 ENOG41079KZ Major Facilitator Superfamily FHP22_01075 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHP22_01080 ENOG4105CEY Amp-dependent synthetase and ligase FHP22_01095 ENOG4105F0N pyrophosphate phospho-hydrolase FHP22_01110 ENOG4105C0P Mg chelatase subunit ChlI FHP22_01125 ENOG4105BZU Histidine kinase FHP22_01135 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FHP22_01150 ENOG4105DQR SNARE associated Golgi FHP22_01175 ENOG4108M8S permease YjgP YjgQ family protein FHP22_01180 ENOG4108K5H permease YjgP YjgQ family protein FHP22_01185 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FHP22_01195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FHP22_01200 ENOG4107TUY Histidine kinase FHP22_01210 ENOG41061WM D-Alanyl-D-Alanine FHP22_01220 ENOG4105D6E homoserine dehydrogenase FHP22_01225 ENOG4105T95 Thiol disulfide interChange protein FHP22_01230 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHP22_01240 ENOG4105CE1 Ferrous iron transport protein b FHP22_01255 ENOG4105CNI cell division protein FtsW FHP22_01265 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FHP22_01270 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FHP22_01275 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FHP22_01280 ENOG41087AY ADP-Ribose pyrophosphatase FHP22_01300 ENOG4108UTW Plays a role in the regulation of phosphate uptake FHP22_01305 ENOG4108RS6 transposase FHP22_01325 ENOG4108HRK Histidine kinase FHP22_01330 ENOG4108NEV two component transcriptional regulator, LytTR family FHP22_01335 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FHP22_01360 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FHP22_01375 ENOG4105GVR general secretion pathway protein D FHP22_01385 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FHP22_01425 ENOG4105PM1 preprotein translocase subunit SecE FHP22_01430 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FHP22_01440 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FHP22_01455 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHP22_01460 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHP22_01480 ENOG4105D3Y Na H antiporter FHP22_01500 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FHP22_01520 ENOG4105DQ6 Transposase FHP22_01550 ENOG4107ZXU DSBA oxidoreductase FHP22_01560 ENOG4105C2W permease FHP22_01570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHP22_01585 ENOG4106H31 ATP-dependent protease ATP-binding subunit-like protein FHP22_01590 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FHP22_01600 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FHP22_01605 ENOG4105BZ1 (ABC) transporter FHP22_01620 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FHP22_01630 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FHP22_01635 ENOG4105NBK UPF0345 protein FHP22_01640 ENOG4105C2N RNA methyltransferase TrmH family group 3 FHP22_01650 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FHP22_01665 ENOG4107QHF type ii secretion system protein e FHP22_01675 ENOG4107EJC Preprotein translocase subunit SecG FHP22_01700 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FHP22_01705 ENOG4105CHV Transcription elongation factor NusA FHP22_01715 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FHP22_01720 ENOG4105KJM monovalent cation h antiporter subunit g FHP22_01725 ENOG4105W4C monovalent cation H antiporter subunit F FHP22_01730 ENOG4105SC1 monovalent cation H antiporter subunit E FHP22_01735 ENOG4107R4Z monovalent cation h antiporter subunit d FHP22_01740 ENOG4108ZE9 Monovalent cation H antiporter subunit C FHP22_01745 ENOG4105D65 subunit l FHP22_01760 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FHP22_01770 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FHP22_01780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FHP22_01790 ENOG4105CSR polyphosphate kinase 2 FHP22_01800 ENOG4105DSY exodeoxyribonuclease V, gamma FHP22_01805 ENOG4107QKA exodeoxyribonuclease V beta FHP22_01810 ENOG4107QYX exodeoxyribonuclease v alpha FHP22_01815 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FHP22_01830 ENOG4105Z2P Protein of unknown function (DUF465) FHP22_01835 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) FHP22_01845 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FHP22_01855 ENOG4105C25 Primosomal protein n' FHP22_01860 ENOG4105D7Q type ii secretion system FHP22_01865 ENOG4108VAU general secretion pathway protein G FHP22_01875 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FHP22_01880 ENOG4108JU5 Magnesium and cobalt efflux protein FHP22_01885 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FHP22_01890 ENOG4105CS6 Rhs element vgr protein FHP22_01955 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FHP22_01965 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FHP22_01980 ENOG4105C5X domain protein FHP22_01990 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FHP22_02000 ENOG4105BZ8 glutamate synthase FHP22_02010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FHP22_02025 ENOG4105C5I Dehydrogenase FHP22_02055 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FHP22_02070 ENOG41067S9 phage shock protein C, PspC FHP22_02100 ENOG4105C03 ribonuclease FHP22_02110 ENOG4105EI2 Pseudouridine synthase FHP22_02115 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FHP22_02120 ENOG4105IKQ hydratase FHP22_02125 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FHP22_02130 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) FHP22_02135 ENOG4105EPF Outer membrane porin FHP22_02170 ENOG4108W5M transcriptional regulator FHP22_02175 ENOG4105FUY alpha subunit FHP22_02190 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase FHP22_02195 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FHP22_02200 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FHP22_02215 ENOG4105CH6 catalase FHP22_02225 ENOG4105CSU acyl-Coa dehydrogenase FHP22_02240 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FHP22_02245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FHP22_02265 ENOG4105DUM transcriptional regulator, lysR family FHP22_02275 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FHP22_02290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FHP22_02340 ENOG4105D1S lipid A biosynthesis FHP22_02345 ENOG4105C5H ABC transporter FHP22_02350 ENOG41069P5 Protein slyX homolog FHP22_02365 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FHP22_02380 ENOG4105BZW Glycerate kinase FHP22_02390 ENOG4105C4R Atp-dependent dna helicase FHP22_02410 ENOG4105CKD glutathione-regulated potassium-efflux system protein FHP22_02415 ENOG4105W0E 50S ribosomal protein L33 FHP22_02420 ENOG4105KDC 50s ribosomal protein l28 FHP22_02425 ENOG4107RGH Aldehyde dehydrogenase FHP22_02430 ENOG41062JF Transcriptional regulator FHP22_02435 ENOG4105CIY formyltetrahydrofolate deformylase FHP22_02465 ENOG4107S2Z UPF0761 membrane protein FHP22_02470 ENOG4105CS1 NAD(P)H quinone oxidoreductase FHP22_02525 ENOG4105C9A Phoh family FHP22_02530 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FHP22_02535 ENOG4105E4C Lytic transglycosylase catalytic FHP22_02575 ENOG4105D6S protein involved in catabolism of external DNA FHP22_02580 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FHP22_02630 ENOG4107QPB Beta-lactamase domain protein FHP22_02645 ENOG4105NAU thioesterase Superfamily protein FHP22_02655 ENOG4108VPT UPF0234 protein FHP22_02675 ENOG4105K9H YciI-like protein FHP22_02685 ENOG4105DB7 PHP domain protein FHP22_02690 ENOG4105FFC UPF0187 protein FHP22_02700 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FHP22_02710 ENOG4105VW4 glutaredoxin 3 FHP22_02720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FHP22_02725 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FHP22_02740 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FHP22_02745 ENOG4105CS6 Rhs element vgr protein FHP22_02755 ENOG41068JE domain protein FHP22_02780 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FHP22_02785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FHP22_02790 ENOG4105DJY efflux transporter, rnd family, mfp subunit FHP22_02815 ENOG4105C7K acetolactate synthase FHP22_02820 ENOG4108ZP8 Acetolactate synthase small subunit FHP22_02870 ENOG4105WVQ Fe-S assembly protein IscX FHP22_02890 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FHP22_02900 ENOG4105CUT histidyl-tRNA synthetase FHP22_02910 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FHP22_02925 ENOG4105DXN mazG family FHP22_02930 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FHP22_02935 ENOG4105DJ0 Poly(A) Polymerase FHP22_02940 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FHP22_02955 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FHP22_02965 ENOG4105N42 UPF0307 protein FHP22_02970 ENOG4105CEY Amp-dependent synthetase and ligase FHP22_02985 ENOG4105CYM Glutathione S-transferase FHP22_02990 ENOG4105W39 Membrane FHP22_03005 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FHP22_03025 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FHP22_03040 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FHP22_03050 ENOG4105C9X ppx gppa phosphatase FHP22_03060 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FHP22_03065 ENOG4105II7 pyrroline-5-carboxylate reductase FHP22_03070 ENOG4108VIA integral membrane protein FHP22_03075 ENOG4105C2M dna polymerase I FHP22_03095 ENOG4107QHF type ii secretion system protein e FHP22_03160 ENOG4105KB2 stringent starvation protein b FHP22_03165 ENOG4107MKT Stringent starvation protein a FHP22_03170 ENOG4108UJD 30S ribosomal protein S9 FHP22_03180 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FHP22_03185 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FHP22_03190 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FHP22_03220 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FHP22_03230 ENOG4107RZC phospholipase d FHP22_03235 ENOG4105DIN metallophosphoesterase FHP22_03245 ENOG4105CSH Transporter FHP22_03250 ENOG4108UT2 hemolysin iii FHP22_03260 ENOG41082BV acetyltransferase FHP22_03275 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHP22_03280 ENOG4105CHU acetyl-coa acetyltransferase FHP22_03285 ENOG4108R6W Transcriptional regulator, ARAC family FHP22_03295 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FHP22_03310 ENOG4105CHU acetyl-coa acetyltransferase FHP22_03320 ENOG4108WHA ompa motb domain protein FHP22_03330 ENOG4108IQI permease FHP22_03340 ENOG4105C2W permease FHP22_03350 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FHP22_03355 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHP22_03365 ENOG4108K4C ec 3.1.3.12 FHP22_03370 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FHP22_03380 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FHP22_03395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHP22_03410 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FHP22_03415 ENOG4108I0Z Aconitate hydratase FHP22_03440 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FHP22_03445 ENOG4105D3G Pseudouridine synthase FHP22_03460 ENOG4105K78 MarR family Transcriptional regulator FHP22_03465 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FHP22_03475 ENOG4105DSF transport protein FHP22_03515 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium FHP22_03535 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FHP22_03555 ENOG4105HF0 Membrane FHP22_03565 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FHP22_03570 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FHP22_03575 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FHP22_03580 ENOG4108UWD Iron-storage protein FHP22_03585 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHP22_03595 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FHP22_03600 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHP22_03610 ENOG4105FE9 pseudouridine synthase FHP22_03615 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FHP22_03620 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FHP22_03630 ENOG4107RTD sua5 ycio yrdc ywlc family protein FHP22_03635 ENOG4108BPE -transporting atpase FHP22_03640 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FHP22_03645 ENOG4105VGS 50s ribosomal protein l32 FHP22_03650 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FHP22_03655 ENOG4105CHR reductase FHP22_03665 ENOG4109066 lysm domain bon superfamily protein FHP22_03670 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FHP22_03680 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FHP22_03685 ENOG4107EXC regulatoR FHP22_03690 ENOG4105JJR Histidine kinase FHP22_03695 ENOG4105CK7 Sodium proline symporter FHP22_03710 ENOG4105D78 K07001 NTE family protein FHP22_03725 ENOG4108UHE carbonic anhydrase FHP22_03730 ENOG4105CDA abc transporter atp-binding protein FHP22_03735 ENOG4105DRP amino acid AbC transporter FHP22_03740 ENOG4105EAD ABC transporter FHP22_03745 ENOG4107RP9 extracellular solute-binding protein, family 3 FHP22_03750 ENOG4107VMU Membrane FHP22_03770 ENOG4105D5G Transposase FHP22_03785 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FHP22_03795 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FHP22_03800 ENOG4105K8R UPF0145 protein FHP22_03805 ENOG4105K8R UPF0145 protein FHP22_03815 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FHP22_03820 ENOG4105BZS acriflavin resistance protein FHP22_03825 ENOG4105C1P efflux transporter, rnd family, mfp subunit FHP22_03830 ENOG410841Q phosphoesterase PA-phosphatase related protein FHP22_03855 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FHP22_03865 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FHP22_03870 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FHP22_03875 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FHP22_03880 ENOG4105CUB amino acid FHP22_03900 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FHP22_03935 ENOG4107T5V SNARE associated Golgi FHP22_03975 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FHP22_04005 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FHP22_04020 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FHP22_04030 ENOG4108RS6 transposase FHP22_04035 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FHP22_04040 ENOG4105C34 Pseudouridine synthase FHP22_04045 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FHP22_04055 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FHP22_04065 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FHP22_04095 ENOG4105C4K Nad synthetase FHP22_04110 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FHP22_04125 ENOG4105F95 Monooxygenase FHP22_04135 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FHP22_04140 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FHP22_04150 ENOG4105E33 succinate dehydrogenase FHP22_04155 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FHP22_04160 ENOG4105C7S Dehydrogenase FHP22_04165 ENOG4107QN2 dihydrolipoyl dehydrogenase FHP22_04175 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FHP22_04185 ENOG4107BJW polysaccharide deacetylase FHP22_04190 ENOG4105CND Glycosyl transferase, family 2 FHP22_04200 ENOG4107S78 Band 7 protein FHP22_04215 ENOG4105CKW Inner membrane protein yedI FHP22_04220 ENOG4105CGZ zinc metallopeptidase FHP22_04230 ENOG4108YV4 Universal stress protein FHP22_04235 ENOG4105EQK -acetyltransferase FHP22_04240 ENOG4105CVP deoxyribo-dipyrimidine photolyase FHP22_04250 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FHP22_04255 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FHP22_04270 ENOG4105HBR Rna-binding protein FHP22_04280 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FHP22_04290 ENOG4105EEI dihydropteroate synthase FHP22_04325 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FHP22_04375 ENOG4105BZS acriflavin resistance protein FHP22_04380 ENOG4105CJW magnesium transporter FHP22_04390 ENOG4105D0M Protease HtpX homolog FHP22_04395 ENOG4105E4C Lytic transglycosylase catalytic FHP22_04400 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FHP22_04410 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FHP22_04415 ENOG4108RRZ Transcription elongation factor GreB FHP22_04435 ENOG4107QKW extracellular solute-binding protein family 1 FHP22_04440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FHP22_04445 ENOG4105C2I pirin domain protein FHP22_04460 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FHP22_04465 ENOG4105NX3 Membrane FHP22_04480 ENOG4105BZU Histidine kinase FHP22_04490 ENOG4105EUJ GTP cyclohydrolase i FHP22_04510 ENOG4105DDQ anthranilate synthase FHP22_04515 ENOG4105C5F glutamine synthetase FHP22_04525 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FHP22_04535 ENOG4108W5M transcriptional regulator FHP22_04570 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHP22_04575 ENOG4107QNR UPF0135 protein FHP22_04580 ENOG4105C0H protease FHP22_04590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FHP22_04595 ENOG4105BZG amino acid carrier protein FHP22_04600 ENOG4105C85 amino acid FHP22_04610 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FHP22_04625 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHP22_04635 ENOG4108YXU transcriptional regulator AsnC family FHP22_04640 ENOG4105N14 lysine exporter protein LysE YggA FHP22_04645 ENOG4105BZJ Electron transfer flavoprotein FHP22_04650 ENOG4105C10 Electron transfer flavoprotein FHP22_04660 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHP22_04680 ENOG4108UPT UPF0178 protein FHP22_04695 ENOG4105D60 lipoprotein releasing system transmembrane protein FHP22_04700 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FHP22_04705 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FHP22_04725 ENOG4108V3E phosphoribosylglycinamide formyltransferase FHP22_04730 ENOG4105CXB phosphoribosylaminoimidazole synthetase FHP22_04735 ENOG4105C02 permease FHP22_04740 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FHP22_04785 ENOG4105KCK Peptidoglycan-associated lipoprotein FHP22_04790 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FHP22_04800 ENOG4105M8F Biopolymer transport protein exbD tolR FHP22_04805 ENOG4105E02 MotA TolQ exbB proton channel FHP22_04810 ENOG4107YD3 Thioesterase FHP22_04820 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FHP22_04850 ENOG4105DAX Pfam:DUF2983 FHP22_04900 ENOG4108ETH Formylglycinamide ribotide synthetase FHP22_04920 ENOG4105CGU Enoyl-CoA hydratase FHP22_04930 ENOG4108YYC ycei family FHP22_04935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHP22_04945 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FHP22_04950 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FHP22_04970 ENOG4107R11 Transcriptional regulator FHP22_04975 ENOG4108IJ6 ABC transporter FHP22_04985 ENOG4108I5D sulfate abc transporter FHP22_04995 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FHP22_05005 ENOG4105HHA aminodeoxychorismate lyase FHP22_05020 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FHP22_05025 ENOG4108IYU L-aspartate oxidase FHP22_05030 ENOG4105C0H protease FHP22_05045 ENOG4105C3F Signal peptidase i FHP22_05055 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FHP22_05060 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FHP22_05070 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FHP22_05075 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FHP22_05080 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FHP22_05100 ENOG4105CHM Aminotransferase FHP22_05135 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FHP22_05145 ENOG4105DTR rard protein FHP22_05165 ENOG4105ECR NmrA family FHP22_05170 ENOG4105KVH Transcriptional regulator FHP22_05175 ENOG4105EQ0 Major Facilitator superfamily FHP22_05185 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FHP22_05265 ENOG4108JPW Aminotransferase FHP22_05270 ENOG4105DY8 decarboxylase FHP22_05280 ENOG4105C8U phosphate abc transporter FHP22_05290 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FHP22_05295 ENOG4105ERU peptidase FHP22_05305 ENOG4107QTF adenylosuccinate lyase FHP22_05330 ENOG4108Z0R Transferase FHP22_05335 ENOG4105DZ1 carboxypeptidase FHP22_05350 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FHP22_05355 ENOG4108K5P (LipO)protein FHP22_05360 ENOG4105EJC lysr family transcriptional regulator FHP22_05365 ENOG4105C8Y Acetylornithine aminotransferase FHP22_05370 ENOG4105M2J Glutaredoxin FHP22_05375 ENOG4105DAN ATP-dependent protease FHP22_05390 ENOG4105DHU Bile acid FHP22_05410 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FHP22_05415 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FHP22_05420 ENOG4105D22 carbon starvation protein FHP22_05425 ENOG4105VCD cytoplasmic protein FHP22_05430 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FHP22_05440 ENOG4105F8C transglutaminase domain-containing protein FHP22_05455 ENOG4105N82 Endonuclease FHP22_05530 ENOG4105RDA repressor FHP22_05580 ENOG4105EFC phage portal protein HK97 family FHP22_05750 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FHP22_05750 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FHP22_05765 ENOG4108R1E Serine threonine protein phosphatase 1 FHP22_05785 ENOG4105C7N Xanthine uracil vitamin C permease FHP22_05790 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FHP22_05800 ENOG4105C3Q Glycosyl transferase, family 2 FHP22_05810 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FHP22_05820 ENOG4105CFH Aspartokinase FHP22_05830 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FHP22_05845 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FHP22_05850 ENOG4108K0D peptidase, M48 FHP22_05865 ENOG4105CPC Aldo Keto reductase FHP22_05870 ENOG4107RYR Transcriptional regulator, Crp Fnr family FHP22_05875 ENOG4108UKZ OsmC family FHP22_05880 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FHP22_05895 ENOG4105CXT aspartate transcarbamylase FHP22_05900 ENOG4105CD3 dihydroorotase FHP22_05905 ENOG4105CDV Ompa motb domain protein FHP22_05910 ENOG4107QNJ CoA-transferase subunit B FHP22_05920 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FHP22_05930 ENOG4105E39 Enoyl-CoA hydratase FHP22_05935 ENOG4107QX3 carboxylase FHP22_05940 ENOG4105C1G acyl-Coa dehydrogenase FHP22_05945 ENOG4108SGK Tetr family transcriptional regulator FHP22_05950 ENOG4105CEY Amp-dependent synthetase and ligase FHP22_05970 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FHP22_05980 ENOG4105CHH sulfate transporter FHP22_05985 ENOG4108K3A Glutathione S-transferase FHP22_06000 ENOG4105M08 Membrane FHP22_06005 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHP22_06015 ENOG4105VEQ Cold shock protein FHP22_06020 ENOG4105C1J atp-dependent rna helicase FHP22_06065 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FHP22_06085 ENOG4105ERG peptidase m48, ste24p FHP22_06100 ENOG4105KTH gatB Yqey FHP22_06105 ENOG4105VCC 30S ribosomal protein S21 FHP22_06130 ENOG4105D9P serine threonine protein kinase FHP22_06170 ENOG4105EXC Acyl-transferase FHP22_06175 ENOG4105CHM Aminotransferase FHP22_06180 ENOG4105E0X reductase FHP22_06185 ENOG4108V06 Glutathione peroxidase FHP22_06195 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FHP22_06205 ENOG4105ZED uncharacterized protein ygaH FHP22_06210 ENOG4108UMN azlc family FHP22_06220 ENOG4105C3G gtp-binding protein FHP22_06245 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FHP22_06285 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FHP22_06290 ENOG4107R0V Pyruvate dehydrogenase FHP22_06295 ENOG4105CPP Dehydrogenase, E1 component FHP22_06300 ENOG4105C7S Dehydrogenase FHP22_06310 ENOG4105CHR reductase FHP22_06325 ENOG4105D5G Transposase FHP22_06345 ENOG4108UKI Enoyl-CoA hydratase FHP22_06350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHP22_06355 ENOG4105CHU acetyl-coa acetyltransferase FHP22_06360 ENOG4105DZS Phenylacetate-CoA ligase FHP22_06365 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FHP22_06370 ENOG4108Z0R Transferase FHP22_06375 ENOG4105CEY Amp-dependent synthetase and ligase FHP22_06395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FHP22_06400 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FHP22_06405 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FHP22_06425 ENOG4105CCF Lysine exporter protein (Lyse ygga) FHP22_06440 ENOG4105N0V mono-oxygenase ydhR FHP22_06445 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FHP22_06450 ENOG4105CV1 Transketolase (EC 2.2.1.1) FHP22_06460 ENOG4108YYC ycei family FHP22_06470 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FHP22_06480 ENOG4107RR1 TRANSCRIPTIONal FHP22_06490 ENOG4105C0A alcohol dehydrogenase FHP22_06500 ENOG4107QUV Domain protein FHP22_06505 ENOG4105DZ2 Transcriptional regulator FHP22_06515 ENOG4108VMM UPF0756 membrane protein FHP22_06520 ENOG4105I08 Pseudouridine synthase FHP22_06540 ENOG4105K8N protein family UPF0079, ATPase FHP22_06545 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FHP22_06555 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FHP22_06560 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FHP22_06565 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FHP22_06570 ENOG4105EHM Aminoglycoside phosphotransferase FHP22_06575 ENOG4108S0S Nucleotidyl transferase FHP22_06585 ENOG4107QJE Chromosome Partitioning Protein FHP22_06590 ENOG4105FA0 parb-like partition protein FHP22_06605 ENOG4105BZ1 (ABC) transporter FHP22_06610 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FHP22_06620 ENOG4107QRG dna polymerase iii FHP22_06630 ENOG4105F8V Hydrolase, tatD family FHP22_06655 ENOG4108RTD type II secretion system protein K FHP22_06665 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FHP22_06675 ENOG4108Z6B deaminase FHP22_06690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FHP22_06695 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FHP22_06705 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FHP22_06710 ENOG4105DWU Membrane FHP22_06715 ENOG4107RN6 Monooxygenase FHP22_06725 ENOG4105D6Z AFG1 family ATPase FHP22_06735 ENOG4107QP3 malate synthase g FHP22_06760 ENOG4105EE5 Membrane protein terC FHP22_06765 ENOG4105VNT transposase (IS4 family) protein FHP22_06785 ENOG4105CWM branched-chain amino acid transport system II carrier protein FHP22_06790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FHP22_06795 ENOG4105CC0 LysR family Transcriptional regulator FHP22_06805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FHP22_06810 ENOG4105CUX Signal transduction histidine kinase FHP22_06825 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FHP22_06830 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FHP22_06835 ENOG4105KNE Phosphatidate cytidylyltransferase FHP22_06845 ENOG4105DZP Membrane-associated zinc metalloprotease FHP22_06850 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FHP22_06870 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FHP22_06900 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FHP22_06905 ENOG4107TSN permease FHP22_06910 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FHP22_06915 ENOG4105E7U AraC family transcriptional regulator FHP22_06920 ENOG4105EEF Alkane 1-monooxygenase FHP22_06925 ENOG4108MJ3 acetyltransferase FHP22_06930 ENOG4105C1G acyl-Coa dehydrogenase FHP22_06935 ENOG4105C1G acyl-Coa dehydrogenase FHP22_06955 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FHP22_06975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FHP22_06980 ENOG4105C4M (Ubiquinol oxidase) subunit I FHP22_06990 ENOG4105PV3 Inner membrane protein yqiJ FHP22_07015 ENOG4105HDD phospholipase FHP22_07020 ENOG4105CZN Potassium uptake protein FHP22_07030 ENOG4105C7B Threonine dehydratase FHP22_07035 ENOG4105E66 phosphoriboisomerase A FHP22_07055 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FHP22_07060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FHP22_07090 ENOG4105CR4 methylisocitrate lyase FHP22_07095 ENOG4105BZN citrate synthase FHP22_07105 ENOG4105CEV competence damage-inducible protein FHP22_07140 ENOG4105D8G Major Facilitator superfamily FHP22_07155 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FHP22_07160 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FHP22_07195 ENOG4105EV9 Alpha Beta Hydrolase FHP22_07225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FHP22_07420 ENOG4105HF0 Membrane FHP22_07425 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FHP22_07440 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 FHP22_07460 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FHP22_07465 ENOG4107QX9 Thiol disulfide interChange protein FHP22_07470 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FHP22_07480 ENOG4105DHQ Histidine kinase FHP22_07495 ENOG4105C26 Dehydrogenase FHP22_07500 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FHP22_07505 ENOG4105C94 Transporter FHP22_07540 ENOG4107KET secretion protein, HlyD family FHP22_07570 ENOG4105CEY Amp-dependent synthetase and ligase FHP22_07580 ENOG4108IPT Naphthoate synthase FHP22_07590 ENOG4108U05 Transcriptional regulator FHP22_07595 ENOG4107RGD Major Facilitator superfamily FHP22_07610 ENOG4105CEY Amp-dependent synthetase and ligase FHP22_07620 ENOG4107RN6 Monooxygenase FHP22_07625 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHP22_07630 ENOG4105CSU acyl-Coa dehydrogenase FHP22_07635 ENOG4105EA8 2-Nitropropane dioxygenase FHP22_07640 ENOG4108UKI Enoyl-CoA hydratase FHP22_07645 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FHP22_07650 ENOG4105MP9 class II Aldolase FHP22_07660 ENOG4105CHU acetyl-coa acetyltransferase FHP22_07665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHP22_07670 ENOG4105E39 Enoyl-CoA hydratase FHP22_07675 ENOG4107RGD Major Facilitator superfamily FHP22_07690 ENOG4107QNJ CoA-transferase subunit B FHP22_07695 ENOG4107QP7 CoA-transferase subunit A FHP22_07700 ENOG4107RGD Major Facilitator superfamily FHP22_07705 ENOG4105C1G acyl-Coa dehydrogenase FHP22_07710 ENOG4105C1G acyl-Coa dehydrogenase FHP22_07720 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FHP22_07730 ENOG4105TMB Formate nitrite transporter FHP22_07735 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FHP22_07750 ENOG4106UW1 Major Facilitator superfamily FHP22_07790 ENOG4105D2S major facilitator superfamily FHP22_07795 ENOG4108KB2 LysR family Transcriptional regulator FHP22_07800 ENOG4105DTQ mandelate racemase muconate lactonizing FHP22_07805 ENOG4105NN7 muconolactone delta-isomerase FHP22_07815 ENOG4105FUY alpha subunit FHP22_07820 ENOG4108UKV benzoate 1,2-dioxygenase FHP22_07825 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FHP22_07830 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase FHP22_07835 ENOG4105DKK Benzoate FHP22_07840 ENOG4107QP7 CoA-transferase subunit A FHP22_07845 ENOG4107QNJ CoA-transferase subunit B FHP22_07850 ENOG4105CHU acetyl-coa acetyltransferase FHP22_07855 ENOG4105F2Z 3-oxoadipate enol-lactonase FHP22_07880 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FHP22_07885 ENOG4105E0C molybdate abc transporter FHP22_07890 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FHP22_07895 ENOG4105CVM Molybdenum cofactor synthesis domain protein FHP22_07900 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FHP22_07930 ENOG4108IFG nitrite reductase, (NAD(P)H) FHP22_07935 ENOG4107QZF nitrite reductase NADPH large subunit FHP22_07940 ENOG4107RNU major facilitator superfamily MFS_1 FHP22_07955 ENOG4105C6T cysteine synthase FHP22_07965 ENOG41080HT Transcriptional regulator, arsr family FHP22_07985 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FHP22_07990 ENOG4105CUY Mechanosensitive ion channel FHP22_08000 ENOG4105BZ1 (ABC) transporter FHP22_08010 ENOG4108ZX5 transcriptional regulator FHP22_08020 ENOG4105CZM Major Facilitator FHP22_08045 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FHP22_08055 ENOG4105C85 amino acid FHP22_08060 ENOG4105CGF Aromatic amino acid aminotransferase FHP22_08065 ENOG4105BZU Histidine kinase FHP22_08075 ENOG4107RZC phospholipase d FHP22_08115 ENOG4105C1G acyl-Coa dehydrogenase FHP22_08125 ENOG4105KK6 nuclease FHP22_08135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FHP22_08140 ENOG4105C4M (Ubiquinol oxidase) subunit I FHP22_08150 ENOG4105CZM Major Facilitator FHP22_08155 ENOG4105CF7 AraC family transcriptional regulator FHP22_08160 ENOG4105CSU acyl-Coa dehydrogenase FHP22_08170 ENOG4105X58 receptor FHP22_08185 ENOG4105CMR udp-glucose 4-epimerase FHP22_08190 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FHP22_08210 ENOG4105CMU LysR family (Transcriptional regulator FHP22_08215 ENOG4105VAW lrga family FHP22_08220 ENOG41067MG lrgb family FHP22_08225 ENOG4108Z66 YbaK ebsC protein FHP22_08240 ENOG4107RKG DJ-1/PfpI family FHP22_08285 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FHP22_08320 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FHP22_08325 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FHP22_08355 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FHP22_08365 ENOG4105C28 cystathionine FHP22_08385 ENOG4105K59 histidine triad (HIT) protein FHP22_08410 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHP22_08415 ENOG4105K70 DNA-binding protein FHP22_08430 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FHP22_08440 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FHP22_08445 ENOG4108Z4V iron-sulfur cluster assembly FHP22_08460 ENOG4108ZIT Ferredoxin, 2FE-2S FHP22_08465 ENOG4105F8J Adenylate Guanylate cyclase FHP22_08475 ENOG4108JA2 transcriptioN-repair coupling factor FHP22_08490 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FHP22_08495 ENOG4105K4T epimerase FHP22_08500 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FHP22_08515 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FHP22_08520 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FHP22_08525 ENOG4105VEJ Heat shock protein FHP22_08535 ENOG4105Y3E Modulates RecA activity (By similarity) FHP22_08550 ENOG4105CNI cell division protein FtsW FHP22_08560 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FHP22_08565 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FHP22_08595 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHP22_08610 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FHP22_08615 ENOG4107RGD Major Facilitator superfamily FHP22_08620 ENOG4105C1G acyl-Coa dehydrogenase FHP22_08625 ENOG4105W8I Transcriptional regulator FHP22_08630 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FHP22_08635 ENOG4108IJ0 Aspartate ammonia-lyase FHP22_08645 ENOG4105EW9 transcriptional regulator AsnC family FHP22_08650 ENOG4105C26 Dehydrogenase FHP22_08670 ENOG4108T58 Mg2 transport protein CorA FHP22_08695 ENOG4105CNV Aldolase FHP22_08700 ENOG4108RCM Nitroreductase FHP22_08710 ENOG4108TZV Membrane FHP22_08715 ENOG4105D2N Aldolase FHP22_08735 ENOG4108UHJ MAF-like protein FHP22_08740 ENOG4105EZE Cupin 4 family protein FHP22_08745 ENOG4105BZU Histidine kinase FHP22_08755 ENOG4105CBC glutamate synthase FHP22_08775 ENOG4105KJF protein tyrosine phosphatase FHP22_08780 ENOG4105C0A alcohol dehydrogenase FHP22_08790 ENOG4107QMP dna polymerase iii subunits gamma and tau FHP22_08810 ENOG4105CHR reductase FHP22_08815 ENOG4105CHU acetyl-coa acetyltransferase FHP22_08825 ENOG4105EVZ LysR family transcriptional regulator FHP22_08830 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FHP22_08835 ENOG4108NIW Leucine export protein LeuE FHP22_08840 ENOG4105DKK Benzoate FHP22_08850 ENOG41081QV Universal stress protein FHP22_08865 ENOG4105CD8 aminopeptidase N FHP22_08895 ENOG4105D6U Sodium Glutamate Symporter FHP22_08925 ENOG4107QIJ Aconitate hydratase 2 FHP22_08950 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FHP22_08955 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) FHP22_08965 ENOG4105KRF dihydroneopterin aldolase FHP22_08975 ENOG4105D06 uba thif-type nad fad binding protein FHP22_08990 ENOG4105C1G acyl-Coa dehydrogenase FHP22_09010 ENOG4105FFC UPF0187 protein FHP22_09015 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FHP22_09020 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FHP22_09040 ENOG4105DEN Luciferase family FHP22_09065 ENOG4105E2S oxidase) subunit II FHP22_09070 ENOG4105BZ9 Cytochrome C oxidase, subunit I FHP22_09075 ENOG4105CCU oxidase (Subunit III) FHP22_09080 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FHP22_09095 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FHP22_09105 ENOG4105CDU Replicative dna helicase FHP22_09110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FHP22_09175 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FHP22_09180 ENOG4105DC1 bifunctional purine biosynthesis protein purh FHP22_09185 ENOG4105C12 Phosphoribosylglycinamide synthetase FHP22_09195 ENOG4105D01 (LipO)protein FHP22_09200 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FHP22_09205 ENOG4108UMI ABC transporter, permease FHP22_09210 ENOG4105C0B DNA polymerase III (alpha subunit) FHP22_09245 ENOG4108Z4U Ferredoxin FHP22_09255 ENOG4107ZBN O-methyltransferase FHP22_09275 ENOG4107QZV Type I secretion membrane fusion protein FHP22_09280 ENOG4108JJA ABC, transporter FHP22_09290 ENOG4108IUZ ABC transporter FHP22_09295 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FHP22_09305 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FHP22_09310 ENOG4105C2X Arabinose 5-phosphate isomerase FHP22_09335 ENOG4105CQ7 ATP-dependent helicase FHP22_09340 ENOG4105D3R alkyl hydroperoxide reductase FHP22_09365 ENOG4108JU3 Alkyl hydroperoxide reductase FHP22_09375 ENOG41066VF YeeE YedE family protein FHP22_09400 ENOG4105EA8 2-Nitropropane dioxygenase FHP22_09435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FHP22_09440 ENOG4105VEQ Cold shock protein FHP22_09470 ENOG4107QS8 (LipO)protein FHP22_09515 ENOG4105EJ2 Transcriptional regulator FHP22_09520 ENOG4107R6F Alpha Beta Hydrolase Fold protein FHP22_09530 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FHP22_09535 ENOG4105D3G Pseudouridine synthase FHP22_09550 ENOG4105D5G Transposase FHP22_09590 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FHP22_09630 ENOG4105JAB phenazine biosynthesis protein, phzf family FHP22_09635 ENOG4108MEJ flavin reductase domain protein FHP22_09645 ENOG4105FAA peptidase M23 FHP22_09655 ENOG4108R99 pseudouridine synthase FHP22_09670 ENOG4105DZ1 carboxypeptidase FHP22_09675 ENOG4105CEP NADH dehydrogenase FHP22_09680 ENOG4108YZY peptidylprolyl cis-trans isomerase FHP22_09705 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FHP22_09710 ENOG4105CIH Imidazole acetol-phosphate transaminase FHP22_09715 ENOG4105CQC Prephenate dehydratase FHP22_09720 ENOG4107R7Y intracellular protease Pfpi family FHP22_09725 ENOG4105C1G acyl-Coa dehydrogenase FHP22_09730 ENOG4105CK2 sodium dicarboxylate symporter FHP22_09745 ENOG4105VUT cytoplasmic protein FHP22_09750 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FHP22_09755 ENOG4105BZ4 penicillin-binding protein FHP22_09775 ENOG4105DHQ Histidine kinase FHP22_09780 ENOG4105XJC Two component transcriptional regulator (Winged helix family FHP22_09790 ENOG4107QHF type ii secretion system protein e FHP22_09800 ENOG4108R96 Methyltransferase, YaeB family FHP22_09805 ENOG4105DP0 ferredoxin-NADP reductase FHP22_09825 ENOG4105CAU Arsenical resistance protein, ArsH FHP22_09830 ENOG4105D6J arsenicaL-resistance protein FHP22_09840 ENOG41082YX Transcriptional regulator, arsr family FHP22_09850 ENOG4105CFP Peptidase U32 FHP22_09855 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FHP22_09860 ENOG4108JU3 Alkyl hydroperoxide reductase FHP22_09880 ENOG4105NXH GreA GreB family elongation factor FHP22_09940 ENOG4105DA5 (ABC) transporter FHP22_09945 ENOG4105E3A (ABC) transporter FHP22_09960 ENOG4105CVE Lytic murein transglycosylase FHP22_09985 ENOG4105CE9 30S ribosomal protein S2 FHP22_09990 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FHP22_10010 ENOG4105E2B Taurine dioxygenase FHP22_10020 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FHP22_10025 ENOG4107QPN acyl-Coa dehydrogenase FHP22_10050 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FHP22_10055 ENOG4105SYT Methylenetetrahydrofolate reductase FHP22_10060 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FHP22_10065 ENOG4105BZU Histidine kinase FHP22_10070 ENOG4105C6K Malic enzyme FHP22_10080 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FHP22_10180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHP22_10200 ENOG4105EKE dihydroorotase FHP22_10205 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FHP22_10225 ENOG4108IQI permease FHP22_10255 ENOG4108JQ5 ABC transporter FHP22_10260 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FHP22_10265 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FHP22_10270 ENOG4105E43 Extracellular solute-binding protein, family 5 FHP22_10275 ENOG4105E9H Lytic Murein transglycosylase FHP22_10280 ENOG4107RZZ dna polymerase iii epsilon subunit FHP22_10290 ENOG4105E09 nadh pyrophosphatase FHP22_10295 ENOG4105EBR Carboxylesterase FHP22_10300 ENOG4105W4M Transport-associated protein FHP22_10310 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FHP22_10315 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FHP22_10325 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FHP22_10330 ENOG4105D0A hydroxylase FHP22_10340 ENOG4107RAQ aminopeptidase FHP22_10345 ENOG4105E07 UPF0149 protein FHP22_10375 ENOG4105CXG d-lactate dehydrogenase FHP22_10385 ENOG41073TP transcriptional regulator FHP22_10390 ENOG4105DAA L-lactate FHP22_10400 ENOG4105D5G Transposase FHP22_10415 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FHP22_10430 ENOG4107VAM peptidase, m28 FHP22_10440 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FHP22_10450 ENOG4105D82 Glutamate dehydrogenase FHP22_10455 ENOG4108R3D Electron transport complex FHP22_10460 ENOG4105CSM endonuclease III FHP22_10485 ENOG4105CJN penicillin-binding protein FHP22_10490 ENOG4106H78 methyltransferase FHP22_10505 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FHP22_10525 ENOG4105CQM Urea amidohydrolase subunit alpha FHP22_10545 ENOG4105CHR reductase FHP22_10555 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FHP22_10560 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FHP22_10570 ENOG4107RET Isocitrate lyase FHP22_10580 ENOG4105C37 (CBS) domain FHP22_10605 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FHP22_10610 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FHP22_10630 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FHP22_10635 ENOG4105VCQ rubredoxin FHP22_10640 ENOG4107QZF nitrite reductase NADPH large subunit FHP22_10650 ENOG4105C5Q Transcriptional regulator FHP22_10660 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FHP22_10665 ENOG4107U91 Rhomboid family FHP22_10670 ENOG4105CV6 ABC transporter, permease FHP22_10675 ENOG4108I0Y (ABC) transporter FHP22_10680 ENOG4108UJV acyl-CoA thioesterase i FHP22_10700 ENOG4105D05 Receptor FHP22_10740 ENOG4105CJ3 phosphate transporter FHP22_10745 ENOG4105C3R Methionine synthase FHP22_10750 ENOG4105CSV Glutaminase FHP22_10760 ENOG4105CSH Transporter FHP22_10790 ENOG4105BZU Histidine kinase FHP22_10800 ENOG4108VWS Yaeq family FHP22_10805 ENOG4105CKI cobalamin synthesis protein FHP22_10835 ENOG4108W5M transcriptional regulator FHP22_10840 ENOG4105CZM Major Facilitator FHP22_10845 ENOG4105YIP Tetr family transcriptional regulator FHP22_10860 ENOG4105D78 K07001 NTE family protein FHP22_10865 ENOG4105FGV Chromate FHP22_10870 ENOG4105BZG amino acid carrier protein FHP22_10875 ENOG4105D6U Sodium Glutamate Symporter FHP22_10890 ENOG4105C2C drug resistance transporter, Bcr CflA FHP22_10895 ENOG4105EM2 membrane FHP22_10905 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FHP22_10960 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein FHP22_10965 ENOG4105WD1 Membrane FHP22_10975 ENOG4106BSU Entericidin B FHP22_10990 ENOG4105CBS Chea signal transduction histidine kinase FHP22_10995 ENOG4105C8Q Methyl-accepting chemotaxis FHP22_11000 ENOG4108ZGA chew protein FHP22_11005 ENOG4105M3Z response regulator FHP22_11010 ENOG4108UNF response regulator FHP22_11030 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FHP22_11080 ENOG4105D1F ATP-binding protein FHP22_11085 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FHP22_11125 ENOG4105K6H D-cysteine desulfhydrase FHP22_11140 ENOG4105CBX hi0933 family FHP22_11170 ENOG4105DP0 ferredoxin-NADP reductase FHP22_11175 ENOG4105DUM transcriptional regulator, lysR family FHP22_11180 ENOG4105VEQ Cold shock protein FHP22_11195 ENOG4105C8S subunit m FHP22_11200 ENOG4105D65 subunit l FHP22_11205 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FHP22_11210 ENOG4107UFS subunit j FHP22_11215 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FHP22_11220 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FHP22_11225 ENOG4108IEH NADH dehydrogenase subunit g FHP22_11230 ENOG4107QIZ NADH dehydrogenase FHP22_11235 ENOG4105GKE subunit e FHP22_11250 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FHP22_11260 ENOG4105CTB Polyprenyl synthetase FHP22_11265 ENOG4105C7F AcnD-accessory protein PrpF FHP22_11270 ENOG4105C85 amino acid FHP22_11290 ENOG4108RXX maleylacetoacetate isomerase FHP22_11320 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein FHP22_11330 ENOG4105D8T Acyltransferase FHP22_11335 ENOG4105C03 ribonuclease FHP22_11340 ENOG4108Z03 MAF-like protein FHP22_11345 ENOG4105VQ7 Rod shape-determining protein MreD FHP22_11350 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FHP22_11355 ENOG4105DFF Rod shape-determining protein mreb FHP22_11360 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FHP22_11370 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FHP22_11415 ENOG4105CND Glycosyl transferase, family 2 FHP22_11420 ENOG4107BJW polysaccharide deacetylase FHP22_11450 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FHP22_11455 ENOG4108VUY thioesterase Superfamily protein FHP22_11460 ENOG4105D52 delta-aminolevulinic acid dehydratase FHP22_11465 ENOG4105MWK D-amino acid dehydrogenase, small subunit FHP22_11475 ENOG4107RH8 nuclease SbcCD subunit D FHP22_11480 ENOG4105EYH Exonuclease FHP22_11490 ENOG4105DFA alanine racemase domain protein FHP22_11495 ENOG4105CZX twitching motility protein FHP22_11500 ENOG4105CZX twitching motility protein FHP22_11505 ENOG41090R7 Ferric uptake FHP22_11515 ENOG4105VDB UPF0125 protein FHP22_11565 ENOG4107QKV phosphomannomutase FHP22_11570 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FHP22_11575 ENOG4105C4R Atp-dependent dna helicase FHP22_11580 ENOG4108ZG0 Ompa motb domain protein FHP22_11585 ENOG4106HNH Acyl-transferase FHP22_11595 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FHP22_11600 ENOG4107QMS site-determining protein FHP22_11615 ENOG4105CNU cell division protein FtsK FHP22_11620 ENOG4105C3M thioredoxin reductase FHP22_11625 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FHP22_11635 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FHP22_11660 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FHP22_11675 ENOG4108YXA Membrane FHP22_11685 ENOG4105M4H endoribonuclease L-psp FHP22_11700 ENOG4105EW9 transcriptional regulator AsnC family FHP22_11705 ENOG4107XGZ Hydrolase FHP22_11710 ENOG4105DWF phosphomethylpyrimidine kinase FHP22_11725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FHP22_11730 ENOG4105KPY Small multidrug resistance protein FHP22_11740 ENOG4105E3B Multicopper oxidase FHP22_11750 ENOG4105DJV ribulose-phosphate 3-epimerase FHP22_11765 ENOG4108M3P Membrane FHP22_11785 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FHP22_11790 ENOG41072GX Peptidase M22 Glycoprotease FHP22_11795 ENOG4108Z0R Transferase FHP22_11800 ENOG4105P8F nudix hydrolase FHP22_11815 ENOG4105CRQ synthase (Component I) FHP22_11825 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FHP22_11830 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FHP22_11890 ENOG4108KHX Diguanylate cyclase FHP22_11920 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FHP22_11925 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FHP22_11945 ENOG4105D3R alkyl hydroperoxide reductase FHP22_11960 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FHP22_11965 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FHP22_12000 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FHP22_12010 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FHP22_12015 ENOG4108WBT adenosyltransferase FHP22_12035 ENOG4105CNG UPF0061 protein FHP22_12040 ENOG4105UNS Pfam:DUF419 FHP22_12050 ENOG4105C85 amino acid FHP22_12060 ENOG4105E3W Two component transcriptional regulator (Winged helix family FHP22_12065 ENOG4105EB3 Histidine kinase FHP22_12075 ENOG4105CSU acyl-Coa dehydrogenase FHP22_12080 ENOG4105CSU acyl-Coa dehydrogenase FHP22_12115 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FHP22_12125 ENOG4105D7V transposase FHP22_12140 ENOG4105UGU tonB-dependent Receptor FHP22_12150 ENOG4105C9M aspartyl-trna synthetase FHP22_12165 ENOG4107QRS glycosyltransferase group 2 family protein FHP22_12170 ENOG4107XU6 Glycosyl transferase (Group 1 FHP22_12190 ENOG4105C6Y Udp-glucose 6-dehydrogenase FHP22_12195 ENOG4105CM2 brancheD-chain amino acid aminotransferase FHP22_12200 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FHP22_12205 ENOG4105BZU Histidine kinase FHP22_12210 ENOG4105E9K Isocitrate dehydrogenase FHP22_12215 ENOG4105DZR Type I site-specific deoxyribonuclease FHP22_12235 ENOG4105CVR type I restriction-modification system FHP22_12250 ENOG4105KT5 UmuD protein FHP22_12295 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FHP22_12305 ENOG4108V0P LemA family FHP22_12320 ENOG4105VIE preprotein translocase, subunit YajC FHP22_12325 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FHP22_12330 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FHP22_12345 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FHP22_12360 ENOG4105C6T cysteine synthase FHP22_12365 ENOG4105BZU Histidine kinase FHP22_12370 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase FHP22_12380 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FHP22_12390 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FHP22_12395 ENOG4105W8H transhydrogenase (subunit alpha FHP22_12400 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FHP22_12405 ENOG4106UX7 integral membrane protein FHP22_12450 ENOG4105CB5 ATP-dependent DNA helicase recG FHP22_12455 ENOG4105CVR type I restriction-modification system FHP22_12505 ENOG4105M8F Biopolymer transport protein exbD tolR FHP22_12510 ENOG4105E02 MotA TolQ exbB proton channel FHP22_12525 ENOG4105BZU Histidine kinase FHP22_12530 ENOG4108ZX5 transcriptional regulator FHP22_12540 ENOG4105G6Z alkaline phosphatase FHP22_12545 ENOG4105G6Z alkaline phosphatase FHP22_12555 ENOG4105D5G Transposase FHP22_12580 ENOG4105D5G Transposase FHP22_12615 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FHP22_12620 ENOG4105VNT transposase (IS4 family) protein FHP22_12625 ENOG4105CUZ uba thif-type nad fad binding protein FHP22_12630 ENOG4105F8V Hydrolase, tatD family FHP22_12645 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FHP22_12655 ENOG4105BZU Histidine kinase FHP22_12660 ENOG4105CN1 protease FHP22_12690 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FHP22_12695 ENOG4108DNC Involved in acetate metabolism (By similarity) FHP22_12720 ENOG4107GFK fumarate FHP22_12735 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FHP22_12745 ENOG4105D05 Receptor FHP22_12750 ENOG4108IU3 tonb-dependent siderophore receptor FHP22_12755 ENOG4107E2E PKHD-type hydroxylase FHP22_12765 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FHP22_12770 ENOG4105DWV Homoserine O-trans-acetylase FHP22_12775 ENOG4105DWV Homoserine O-trans-acetylase FHP22_12840 ENOG4105QNF Outer membrane lipoprotein FHP22_12870 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FHP22_12905 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FHP22_12910 ENOG4105DGW oligopeptidase A FHP22_12915 ENOG4105VKU nucleicacid-binding protein FHP22_12925 ENOG4105D7V transposase FHP22_12975 ENOG4105C1G acyl-Coa dehydrogenase FHP22_12980 ENOG4105CT3 Monooxygenase FHP22_12990 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHP22_12995 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FHP22_13000 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FHP22_13010 ENOG41067V7 50S ribosomal protein L36 FHP22_13015 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FHP22_13030 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FHP22_13040 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FHP22_13045 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FHP22_13055 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FHP22_13080 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FHP22_13110 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FHP22_13125 ENOG41089BK Glutamine amido-transferase FHP22_13140 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FHP22_13145 ENOG4105KPV Transcriptional regulator FHP22_13165 ENOG4105CK2 sodium dicarboxylate symporter FHP22_13170 ENOG4105C29 acyl-CoA thioesterase FHP22_13175 ENOG4105E55 glycerol-3-phosphate acyltransferase FHP22_13185 ENOG4105CB5 ATP-dependent DNA helicase recG FHP22_13190 ENOG4105MJ2 Competence protein FHP22_13200 ENOG4108URH decarboxylase FHP22_13205 ENOG4107QUT magnesium and cobalt transport protein CorA FHP22_13220 ENOG4105E3I toluene tolerance FHP22_13225 ENOG4107PE3 Mammalian cell entry related domain protein FHP22_13230 ENOG4105CY3 ABC transporter, permease FHP22_13235 ENOG4105DHJ ABC, transporter FHP22_13240 ENOG4105C1J atp-dependent rna helicase FHP22_13245 ENOG4105ECY inositol monophosphatase FHP22_13260 ENOG4105D4P Coproporphyrinogen iii oxidase FHP22_13265 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FHP22_13280 ENOG4105CSU acyl-Coa dehydrogenase FHP22_13285 ENOG4105CSA Coproporphyrinogen iii oxidase FHP22_13295 ENOG4107QI1 Mate efflux family protein FHP22_13305 ENOG4105NRA 50s ribosomal protein l31 type b FHP22_13310 ENOG4105WMR Protein CrcB homolog FHP22_13330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FHP22_13340 ENOG4108RS6 transposase FHP22_13355 ENOG4107SKI cobyrinic Acid a,c-diamide synthase FHP22_13360 ENOG4105IPI Membrane FHP22_13365 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHP22_13370 ENOG4105VCH membrane FHP22_13375 ENOG4107QF7 multi-drug FHP22_13385 ENOG4105CQB FAD linked oxidase domain protein FHP22_13395 ENOG4108JQ1 Dehydrogenase FHP22_13420 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FHP22_13425 ENOG4105D7V transposase FHP22_13430 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) FHP22_13435 ENOG4107IFA Lipase (EC 3.1.1.3) FHP22_13440 ENOG4107IFA Lipase (EC 3.1.1.3) FHP22_13455 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FHP22_13465 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FHP22_13470 ENOG4105K5M 30s ribosomal protein S16 FHP22_13495 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FHP22_13500 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FHP22_13505 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FHP22_13510 ENOG4105KME endoribonuclease L-psp FHP22_13515 ENOG4105W53 bacterioferritin-associated ferredoxin FHP22_13520 ENOG4108UQY Iron-storage protein FHP22_13525 ENOG4108YSG O-Antigen polymerase FHP22_13535 ENOG4105X0D Fimbrial protein FHP22_13545 ENOG4105HA9 of methanol dehydrogenase type FHP22_13550 ENOG4108V0P LemA family FHP22_13560 ENOG4105BZ8 glutamate synthase FHP22_13565 ENOG4105CBC glutamate synthase FHP22_13585 ENOG4105E4G Type IV pilus FHP22_13615 ENOG4108JQC penicillin-binding protein 1A FHP22_13620 ENOG4105VNT transposase (IS4 family) protein FHP22_13625 ENOG4105DHI Methyltransferase FHP22_13635 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FHP22_13640 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FHP22_13645 ENOG4105CJN penicillin-binding protein FHP22_13655 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FHP22_13660 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FHP22_13670 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FHP22_13690 ENOG4105C5H ABC transporter FHP22_13700 ENOG4105PDP Short chain dehydrogenase FHP22_13715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHP22_13720 ENOG4105E0F Histidine kinase FHP22_13725 ENOG4105CYC Transferase FHP22_13755 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FHP22_13775 ENOG4108Q5Y Membrane FHP22_13790 ENOG4105CUV Homoserine Kinase FHP22_13830 ENOG4105DFH Transport of potassium into the cell (By similarity) FHP22_13860 ENOG4105EUB pirin domain protein FHP22_13865 ENOG4105D3R alkyl hydroperoxide reductase FHP22_13875 ENOG4105F9F transposase FHP22_13885 ENOG4105F9F transposase FHP22_13910 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FHP22_13915 ENOG4105VF7 tolerance protein FHP22_13920 ENOG4105EPC oxidoreductase FHP22_13925 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FHP22_13940 ENOG4105F9F transposase FHP22_13975 ENOG4108UUM single-stranded DNA-binding protein FHP22_13980 ENOG4107RDB Major Facilitator FHP22_13990 ENOG4105ETU transcriptional activator (TenA FHP22_14005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FHP22_14010 ENOG4105BZU Histidine kinase FHP22_14040 ENOG4107QN1 sodium solute FHP22_14045 ENOG41062QD Membrane FHP22_14050 ENOG4105BZU Histidine kinase FHP22_14070 ENOG4108UZX fmn reductase FHP22_14080 ENOG4107T8P acyl-Coa dehydrogenase FHP22_14085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FHP22_14090 ENOG4105D64 Mechanosensitive ion channel FHP22_14100 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FHP22_14105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHP22_14130 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FHP22_14145 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FHP22_14165 ENOG4107QSN dihydrolipoamide acetyltransferase FHP22_14170 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FHP22_14190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FHP22_14195 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FHP22_14200 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FHP22_14210 ENOG4105DFU Cell wall formation (By similarity) FHP22_14215 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FHP22_14220 ENOG4105D7Z glutathione synthase FHP22_14230 ENOG4105D5G Transposase FHP22_14280 ENOG4105CGK Exodeoxyribonuclease III FHP22_14285 ENOG4105KUZ arsenate reductase FHP22_14300 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FHP22_14305 ENOG4105BZU Histidine kinase FHP22_14310 ENOG4108K3A Glutathione S-transferase FHP22_14355 ENOG4108Z7F N-acetyltransferase FHP22_14360 ENOG41061H0 Monooxygenase FHP22_14365 ENOG4105DHG Allantoate amidinohydrolase FHP22_14370 ENOG4108Z2U ureidoglycolate hydrolase FHP22_14385 ENOG4105C8P )-transporter FHP22_14395 ENOG4108IV0 ABC, transporter FHP22_14400 ENOG4105C0Z ABC transporter FHP22_14410 ENOG4105C32 Amino acid ABC transporter (Permease) FHP22_14415 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FHP22_14420 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHP22_14425 ENOG4105IPS esterase FHP22_14435 ENOG4105D9M gamma-glutamylcysteine synthetase FHP22_14450 ENOG4106BRA Membrane FHP22_14455 ENOG4105CHM Aminotransferase FHP22_14460 ENOG4107QJQ Mate efflux family protein FHP22_14470 ENOG4108RS6 transposase FHP22_14485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHP22_14490 ENOG4105BZU Histidine kinase FHP22_14500 ENOG4105KHC sulfurtransferase FHP22_14535 ENOG4105EAC phosphoserine phosphatase FHP22_14550 ENOG4105C09 Bile acid FHP22_14555 ENOG4108RWI nicotinamidase FHP22_14560 ENOG4108SC4 )-transporter FHP22_14565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FHP22_14575 ENOG4105C8V SAICAR synthetase FHP22_14580 ENOG4105D1H recombination factor protein RarA FHP22_14585 ENOG4108ZZ3 UPF0260 protein FHP22_14605 ENOG4105CEN a g-specific adenine glycosylase FHP22_14610 ENOG4105FAA peptidase M23 FHP22_14620 ENOG4108R3E Dna-3-methyladenine glycosylase i FHP22_14625 ENOG4105DQ4 alcohol dehydrogenase FHP22_14630 ENOG4108V1T peptidylprolyl cis-trans isomerase FHP22_14635 ENOG4108V1T peptidylprolyl cis-trans isomerase FHP22_14640 ENOG4105CJR Integral membrane protein (MviN FHP22_14645 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FHP22_14650 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FHP22_14655 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FHP22_14660 ENOG4105EJ2 Transcriptional regulator FHP22_14670 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FHP22_14675 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FHP22_14680 ENOG4105UBK short-chain dehydrogenase reductase FHP22_14700 ENOG4107QZM n-acetylglutamate synthase FHP22_14705 ENOG4105GVF (ABC) transporter FHP22_14710 ENOG4105GVF (ABC) transporter FHP22_14715 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FHP22_14720 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FHP22_14725 ENOG4108VM9 ABC, transporter FHP22_14740 ENOG4108R86 Transcriptional regulator FHP22_14750 ENOG4105DTN riboflavin biosynthesis protein ribF FHP22_14755 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FHP22_14760 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FHP22_14765 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FHP22_14780 ENOG4105D2S major facilitator superfamily FHP22_14810 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FHP22_14855 ENOG4105CVE Lytic murein transglycosylase FHP22_14865 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FHP22_14870 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FHP22_14885 ENOG4105DFU Cell wall formation (By similarity) FHP22_14890 ENOG4108RS6 transposase FHP22_14905 ENOG410830R acetyltransferase FHP22_14915 ENOG4105DU1 integral membrane protein, terc FHP22_14920 ENOG4107QUY Guanine deaminase FHP22_14925 ENOG4108UGV hypoxanthine phosphoribosyltransferase FHP22_14935 ENOG4105T95 Thiol disulfide interChange protein FHP22_14940 ENOG4105PGM cation diffusion facilitator family transporter FHP22_14975 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FHP22_14980 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FHP22_14985 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FHP22_14990 ENOG4105VG0 50S ribosomal protein l34 FHP22_15000 ENOG4105K4U addiction module toxin, RelE StbE family FHP22_15040 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FHP22_15095 ENOG4105I1F Resistance protein FHP22_15110 ENOG4108HWY Beta-lactamase FHP22_15120 ENOG4105C5H ABC transporter FHP22_15130 ENOG4105C5H ABC transporter FHP22_15135 ENOG4105C5H ABC transporter FHP22_15215 ENOG4105E4P ATPase (AAA FHP22_15235 ENOG4108R0M Aminoglycoside FHP22_15280 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FHP22_15330 ENOG4105D5G Transposase FHP22_15360 ENOG4107QJE Chromosome Partitioning Protein FHP22_15380 ENOG4105IYK transposase FHP22_15400 ENOG4107HP6 Transcriptional regulator FHP22_15405 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FHP22_15410 ENOG4107HP6 Transcriptional regulator FHP22_15415 ENOG4107QP7 CoA-transferase subunit A FHP22_15420 ENOG4107QNJ CoA-transferase subunit B FHP22_15425 ENOG4105CHU acetyl-coa acetyltransferase FHP22_15430 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FHP22_15435 ENOG4105F2Z 3-oxoadipate enol-lactonase FHP22_15440 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FHP22_15445 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FHP22_15450 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FHP22_15500 ENOG4105E3J oxidoreductase FHP22_15510 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) FHP22_15515 ENOG4108SC4 )-transporter FHP22_15520 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase FHP22_15535 ENOG4105C1G acyl-Coa dehydrogenase FHP22_15540 ENOG4105EPF Outer membrane porin FHP22_15545 ENOG4105NI3 Protein of unknown function (DUF3237) FHP22_15575 ENOG4105KT5 UmuD protein FHP22_15750 ENOG4105EZN Cobyrinic acid ac-diamide synthase FHP22_15795 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system