locus-tag	class	description
E5093_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5093_00015	COG0594	ribonuclease P activity
E5093_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E5093_00025	COG0706	membrane insertase activity
E5093_00050	COG1230	cation diffusion facilitator family transporter
E5093_00055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5093_00070	COG0402	S-adenosylhomocysteine deaminase activity
E5093_00075	COG0861	Integral membrane protein TerC family
E5093_00085	COG2388	GCN5-related N-acetyl-transferase
E5093_00095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5093_00115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5093_00125	COG2951	lytic endotransglycosylase activity
E5093_00175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5093_00205	COG2814	Major facilitator Superfamily
E5093_00215	COG1012	belongs to the aldehyde dehydrogenase family
E5093_00220	COG0733	neurotransmitter:sodium symporter activity
E5093_00230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5093_00245	COG0129	dihydroxy-acid dehydratase activity
E5093_00260	COG2233	PERMEase
E5093_00270	COG1309	transcriptional regulator
E5093_00275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_00330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5093_00375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5093_00385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5093_00395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5093_00410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5093_00420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5093_00430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5093_00445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E5093_00475	COG1518	maintenance of DNA repeat elements
E5093_00520	COG1337	RAMP superfamily
E5093_00645	COG0556	nucleotide-excision repair
E5093_00650	COG1104	cysteine desulfurase activity
E5093_00660	COG3756	Protein conserved in bacteria
E5093_00695	COG0271	Belongs to the BolA IbaG family
E5093_00705	COG1192	Involved in chromosome partitioning
E5093_00720	COG0586	Pfam SNARE associated Golgi protein
E5093_00725	COG2259	Doxx family
E5093_00730	COG0519	Catalyzes the synthesis of GMP from XMP
E5093_00730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5093_00770	COG0281	malic enzyme
E5093_00775	COG3501	Rhs element vgr protein
E5093_00795	COG2837	iron assimilation
E5093_00805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5093_00810	COG1121	(ABC) transporter
E5093_00860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5093_00890	COG0386	Belongs to the glutathione peroxidase family
E5093_00895	COG0697	spore germination
E5093_00910	COG0758	DNA mediated transformation
E5093_00960	COG2814	Major facilitator Superfamily
E5093_00985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5093_01000	COG2814	Major facilitator Superfamily
E5093_01020	COG1253	flavin adenine dinucleotide binding
E5093_01030	COG2860	membrane
E5093_01035	COG0477	Major facilitator Superfamily
E5093_01045	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_01060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5093_01085	COG0347	Belongs to the P(II) protein family
E5093_01090	COG0004	ammonium transporteR
E5093_01100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5093_01100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5093_01115	COG0586	Pfam SNARE associated Golgi protein
E5093_01140	COG0795	lipopolysaccharide-transporting ATPase activity
E5093_01145	COG0795	lipopolysaccharide-transporting ATPase activity
E5093_01150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5093_01155	COG0793	Belongs to the peptidase S41A family
E5093_01170	COG2197	response regulator
E5093_01180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5093_01195	COG4974	Belongs to the 'phage' integrase family
E5093_01220	COG0772	Belongs to the SEDS family
E5093_01230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5093_01235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5093_01240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5093_01245	COG0494	nUDIX hydrolase
E5093_01280	COG3275	phosphorelay sensor kinase activity
E5093_01290	COG0181	hydroxymethylbilane synthase activity
E5093_01310	COG0824	Thioesterase
E5093_01395	COG0081	regulation of translation
E5093_01410	COG0085	RNA polymerase activity
E5093_01415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5093_01435	COG2056	Na+-H+ antiporter family
E5093_01450	COG0326	Molecular chaperone. Has ATPase activity
E5093_01475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5093_01485	COG2233	PERMEase
E5093_01495	COG1024	Enoyl-CoA hydratase
E5093_01495	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_01525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5093_01530	COG1132	(ABC) transporter
E5093_01545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5093_01555	COG0497	DNA recombination
E5093_01560	COG3123	guanosine phosphorylase activity
E5093_01565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5093_01575	COG0237	dephospho-CoA kinase activity
E5093_01625	COG0779	Required for maturation of 30S ribosomal subunits
E5093_01630	COG0195	Participates in both transcription termination and antitermination
E5093_01640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5093_01650	COG2212	antiporter activity
E5093_01660	COG0651	ATP synthesis coupled electron transport
E5093_01665	COG1006	Multisubunit Na H antiporter MnhC subunit
E5093_01670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5093_01670	COG2111	Na H antiporter
E5093_01685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5093_01695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5093_01725	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5093_01730	COG1074	ATP-dependent DNA helicase activity
E5093_01735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5093_01745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5093_01760	COG2841	Protein conserved in bacteria
E5093_01765	COG0789	Transcriptional regulator
E5093_01775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5093_01785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5093_01805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E5093_01810	COG4535	Mg2 and Co2 transporter CorC
E5093_01815	COG0425	Belongs to the sulfur carrier protein TusA family
E5093_01820	COG3501	Rhs element vgr protein
E5093_01845	COG0644	oxidoreductase
E5093_01845	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5093_01855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5093_01870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5093_01880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5093_01890	COG0493	'glutamate synthase
E5093_01890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5093_01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5093_01945	COG0751	glycine-tRNA ligase activity
E5093_01955	COG0517	IMP dehydrogenase activity
E5093_01955	COG0617	tRNA 3'-terminal CCA addition
E5093_01955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5093_01960	COG1983	PspC domain protein
E5093_01985	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_01990	COG1530	ribonuclease E activity
E5093_02005	COG0546	phosphoglycolate phosphatase activity
E5093_02010	COG3971	2-oxopent-4-enoate hydratase activity
E5093_02015	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E5093_02040	COG0583	DNA-binding transcription factor activity
E5093_02045	COG4638	Rieske (2fe-2S)
E5093_02060	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_02065	COG3384	dioxygenase
E5093_02070	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5093_02085	COG0753	catalase activity
E5093_02095	COG1960	acyl-CoA dehydrogenase activity
E5093_02115	COG0494	nUDIX hydrolase
E5093_02130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5093_02145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5093_02160	COG0473	3-isopropylmalate dehydrogenase activity
E5093_02215	COG1560	Kdo2-lipid A biosynthetic process
E5093_02225	COG2900	Belongs to the SlyX family
E5093_02255	COG1929	Belongs to the glycerate kinase type-1 family
E5093_02265	COG0210	DNA helicase
E5093_02270	COG0724	RNA recognition motif
E5093_02285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5093_02285	COG4651	solute:proton antiporter activity
E5093_02310	COG0788	formyltetrahydrofolate deformylase activity
E5093_02340	COG1295	ribonuclease BN
E5093_02390	COG1702	phosphate starvation-inducible protein PhoH
E5093_02400	COG1196	nuclear chromosome segregation
E5093_02400	COG0739	heme binding
E5093_02400	COG0741	lytic transglycosylase activity
E5093_02440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5093_02445	COG1183	phosphatidylcholine synthase activity
E5093_02510	COG1607	acyl-coa hydrolase
E5093_02520	COG1666	GTP binding
E5093_02540	COG2350	Protein conserved in bacteria
E5093_02550	COG0613	PHP domain protein
E5093_02555	COG3781	membrane
E5093_02565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5093_02575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5093_02585	COG1162	GTPase activity
E5093_02590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5093_02605	COG3501	Rhs element vgr protein
E5093_02630	COG0577	efflux transmembrane transporter activity
E5093_02630	COG1136	(ABC) transporter
E5093_02635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_02660	COG0028	Belongs to the TPP enzyme family
E5093_02665	COG0440	acetolactate synthase activity
E5093_02705	COG2975	iron-sulfur cluster assembly
E5093_02735	COG0124	histidyl-tRNA synthetase
E5093_02745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5093_02760	COG3956	TIGRFAM MazG family protein
E5093_02765	COG1555	photosystem II stabilization
E5093_02770	COG0617	tRNA 3'-terminal CCA addition
E5093_02775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5093_02790	COG1660	Displays ATPase and GTPase activities
E5093_02800	COG3028	Belongs to the UPF0307 family
E5093_02805	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_02820	COG0625	glutathione transferase activity
E5093_02825	COG1238	metal cluster binding
E5093_02860	COG0072	phenylalanine-tRNA ligase activity
E5093_02885	COG0248	Ppx GppA phosphatase
E5093_02895	COG0037	tRNA processing
E5093_02940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5093_02995	COG2969	positive regulation of protein catabolic process
E5093_03000	COG0625	glutathione transferase activity
E5093_03005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5093_03015	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E5093_03020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5093_03025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5093_03060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5093_03070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5093_03075	COG1408	metallophosphoesterase
E5093_03085	COG0477	Major facilitator Superfamily
E5093_03090	COG1272	protein, Hemolysin III
E5093_03110	COG1024	Enoyl-CoA hydratase
E5093_03110	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_03115	COG0183	Belongs to the thiolase family
E5093_03120	COG2207	Transcriptional regulator
E5093_03130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_03145	COG0183	Belongs to the thiolase family
E5093_03165	COG0833	amino acid
E5093_03175	COG2233	PERMEase
E5093_03185	COG1970	mechanosensitive ion channel activity
E5093_03190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5093_03200	COG1877	trehalose-phosphatase activity
E5093_03205	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5093_03215	COG0363	glucosamine-6-phosphate deaminase activity
E5093_03245	COG0354	folic acid binding
E5093_03275	COG0346	lactoylglutathione lyase activity
E5093_03280	COG0564	pseudouridine synthase activity
E5093_03295	COG3189	MarR family transcriptional regulator
E5093_03300	COG2824	Alkylphosphonate utilization operon protein PhnA
E5093_03310	COG0628	permease
E5093_03325	COG1764	response to oxidative stress
E5093_03330	COG1846	Transcriptional regulator
E5093_03340	COG2801	Transposase and inactivated derivatives
E5093_03360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5093_03380	COG0730	response to heat
E5093_03390	COG1196	nuclear chromosome segregation
E5093_03395	COG3115	cell septum assembly
E5093_03400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5093_03405	COG2193	ferroxidase activity
E5093_03410	COG0596	Alpha beta hydrolase
E5093_03410	COG2226	methyltransferase
E5093_03410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_03425	COG4106	trans-aconitate 2-methyltransferase activity
E5093_03440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5093_03445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5093_03455	COG0009	L-threonylcarbamoyladenylate synthase
E5093_03460	COG3101	peptidyl-lysine hydroxylation
E5093_03465	COG1399	metal-binding, possibly nucleic acid-binding protein
E5093_03480	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_03490	COG1652	LysM domain
E5093_03500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5093_03515	COG0745	RESPONSE REGULATOR receiver
E5093_03520	COG2205	protein histidine kinase activity
E5093_03525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5093_03540	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5093_03555	COG3338	carbonate dehydratase activity
E5093_03560	COG1126	abc transporter atp-binding protein
E5093_03565	COG0765	amino acid transport
E5093_03570	COG0765	amino acid transport
E5093_03580	COG2323	membrane
E5093_03595	COG2852	Protein conserved in bacteria
E5093_03605	COG0525	valine-tRNA ligase activity
E5093_03620	COG0393	Putative heavy-metal-binding
E5093_03625	COG0393	Putative heavy-metal-binding
E5093_03635	COG1538	Outer membrane efflux protein
E5093_03645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_03650	COG0671	phosphoesterase, PA-phosphatase related
E5093_03675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5093_03685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5093_03690	COG1648	precorrin-2 dehydrogenase activity
E5093_03690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5093_03695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5093_03700	COG0531	amino acid
E5093_03720	COG0321	lipoyl(octanoyl) transferase activity
E5093_03725	COG2921	Belongs to the UPF0250 family
E5093_03755	COG0586	Pfam SNARE associated Golgi protein
E5093_03795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5093_03825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5093_03840	COG0358	DNA primase activity
E5093_03850	COG0564	pseudouridine synthase activity
E5093_03865	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5093_03875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5093_03905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5093_03905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5093_03920	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E5093_03930	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_03935	COG2072	flavoprotein involved in K transport
E5093_03950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5093_03955	COG1053	succinate dehydrogenase
E5093_03960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5093_03975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5093_03985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E5093_03995	COG1649	PFAM Uncharacterised BCR, COG1649
E5093_03995	COG0726	polysaccharide deacetylase
E5093_04000	COG1215	transferase activity, transferring glycosyl groups
E5093_04010	COG2268	Band 7 protein
E5093_04025	COG2354	Protein conserved in bacteria
E5093_04030	COG2321	neutral zinc metallopeptidase
E5093_04040	COG0589	response to stress
E5093_04045	COG0110	maltose O-acetyltransferase activity
E5093_04050	COG0415	Belongs to the DNA photolyase family
E5093_04065	COG0505	Belongs to the CarA family
E5093_04080	COG1534	Rna-binding protein
E5093_04090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5093_04100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5093_04135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5093_04155	COG1597	lipid kinase activity
E5093_04180	COG0584	glycerophosphoryl diester phosphodiesterase
E5093_04190	COG2239	Acts as a magnesium transporter
E5093_04200	COG0501	Belongs to the peptidase M48B family
E5093_04205	COG0741	lytic transglycosylase activity
E5093_04205	COG0739	heme binding
E5093_04205	COG1196	nuclear chromosome segregation
E5093_04210	COG0037	tRNA processing
E5093_04220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E5093_04225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5093_04300	COG1484	DNA-dependent DNA replication
E5093_04305	COG4584	PFAM Integrase catalytic
E5093_04350	COG3621	Patatin-like phospholipase
E5093_04395	COG1840	ABC-type Fe3 transport system, periplasmic component
E5093_04400	COG3842	ATPase activity
E5093_04405	COG1741	Belongs to the pirin family
E5093_04415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5093_04420	COG3739	integral membrane protein
E5093_04435	COG3706	GGDEF domain
E5093_04470	COG0512	Glutamine amidotransferase of anthranilate synthase
E5093_04475	COG0174	glutamine synthetase
E5093_04485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5093_04530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5093_04535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5093_04555	COG1115	amino acid carrier protein
E5093_04560	COG1113	amino acid transport
E5093_04570	COG0019	diaminopimelate decarboxylase activity
E5093_04585	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5093_04595	COG1522	sequence-specific DNA binding
E5093_04600	COG1280	lysine exporter protein (LysE YggA)
E5093_04640	COG1671	Belongs to the UPF0178 family
E5093_04655	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5093_04660	COG1136	(ABC) transporter
E5093_04665	COG0658	competence protein
E5093_04665	COG2333	competence protein COMEC
E5093_04685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5093_04690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5093_04695	COG0628	permease
E5093_04700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5093_04730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5093_04750	COG0823	Involved in the tonB-independent uptake of proteins
E5093_04770	COG0824	Thioesterase
E5093_04780	COG2255	four-way junction helicase activity
E5093_04800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5093_04800	COG0047	phosphoribosylformylglycinamidine synthase activity
E5093_04815	COG0778	Nitroreductase
E5093_04820	COG1024	Enoyl-CoA hydratase
E5093_04825	COG1051	belongs to the nudix hydrolase family
E5093_04825	COG1056	cytidyltransferase-related domain
E5093_04830	COG2353	YceI-like domain
E5093_04835	COG0583	DNA-binding transcription factor activity
E5093_04845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5093_04855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5093_04860	COG0602	queuosine metabolic process
E5093_04880	COG0583	DNA-binding transcription factor activity
E5093_04885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5093_04890	COG4208	sulfate ABC transporter
E5093_04905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5093_04915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5093_04930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5093_04940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5093_04955	COG0681	Belongs to the peptidase S26 family
E5093_04965	COG0571	ribonuclease III activity
E5093_04970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5093_04980	COG1381	Involved in DNA repair and RecF pathway recombination
E5093_04985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5093_05010	COG0436	Aminotransferase
E5093_05030	COG0556	nucleotide-excision repair
E5093_05060	COG0702	epimerase
E5093_05065	COG1733	regulation of RNA biosynthetic process
E5093_05070	COG2814	Major facilitator Superfamily
E5093_05080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5093_05085	COG0582	viral genome integration into host DNA
E5093_05140	COG0642	Histidine kinase
E5093_05145	COG0745	RESPONSE REGULATOR receiver
E5093_05150	COG2194	sulfuric ester hydrolase activity
E5093_05215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5093_05220	COG0076	glutamate decarboxylase activity
E5093_05230	COG0573	inorganic phosphate transmembrane transporter activity
E5093_05240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5093_05245	COG0616	signal peptide processing
E5093_05300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5093_05305	COG1686	Belongs to the peptidase S11 family
E5093_05320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E5093_05330	COG0583	DNA-binding transcription factor activity
E5093_05335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5093_05340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5093_05345	COG1067	ATP-dependent peptidase activity
E5093_05380	COG1509	lysine 2,3-aminomutase activity
E5093_05385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5093_05390	COG1966	Carbon starvation protein
E5093_05395	COG2879	small protein
E5093_05400	COG0714	Associated with various cellular activities
E5093_05430	COG2252	PERMEase
E5093_05435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5093_05445	COG1215	transferase activity, transferring glycosyl groups
E5093_05455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5093_05465	COG0527	aspartate kinase activity
E5093_05475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5093_05490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5093_05495	COG0501	Belongs to the peptidase M48B family
E5093_05510	COG0667	Aldo Keto reductase
E5093_05520	COG1765	OsmC-like protein
E5093_05550	COG0540	Belongs to the ATCase OTCase family
E5093_05565	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_05580	COG4770	biotin carboxylase activity
E5093_05585	COG1024	Enoyl-CoA hydratase
E5093_05590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5093_05595	COG1960	acyl-CoA dehydrogenase activity
E5093_05600	COG1309	transcriptional regulator
E5093_05605	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_05625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5093_05635	COG0659	secondary active sulfate transmembrane transporter activity
E5093_05655	COG2363	Small membrane protein
E5093_05675	COG0513	Belongs to the DEAD box helicase family
E5093_05740	COG4783	chaperone-mediated protein folding
E5093_05755	COG1610	YqeY-like protein
E5093_05785	COG2815	serine threonine protein kinase
E5093_05785	COG0515	serine threonine protein kinase
E5093_05830	COG0436	Aminotransferase
E5093_05835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E5093_05840	COG0386	Belongs to the glutathione peroxidase family
E5093_05850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E5093_05865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5093_05875	COG0012	GTP binding
E5093_05900	COG0204	Acyl-transferase
E5093_05940	COG3706	GGDEF domain
E5093_05955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5093_05970	COG1414	Transcriptional regulator
E5093_05975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5093_05980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_05985	COG0183	Belongs to the thiolase family
E5093_05990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5093_05995	COG0596	Alpha beta hydrolase
E5093_06025	COG2351	hydroxyisourate hydrolase activity
E5093_06040	COG3046	protein related to deoxyribodipyrimidine photolyase
E5093_06045	COG2816	NAD+ diphosphatase activity
E5093_06070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5093_06085	COG0642	Histidine kinase
E5093_06090	COG0745	RESPONSE REGULATOR receiver
E5093_06120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5093_06155	COG4773	Receptor
E5093_06175	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
E5093_06185	COG5002	protein histidine kinase activity
E5093_06185	COG5001	Diguanylate cyclase
E5093_06200	COG0783	Belongs to the Dps family
E5093_06205	COG2814	Major facilitator Superfamily
E5093_06210	COG2030	dehydratase
E5093_06210	COG1012	belongs to the aldehyde dehydrogenase family
E5093_06215	COG3396	Phenylacetate-CoA oxygenase
E5093_06220	COG3460	Phenylacetate-CoA oxygenase
E5093_06225	COG3396	Phenylacetate-CoA oxygenase
E5093_06230	COG2151	metal-sulfur cluster biosynthetic enzyme
E5093_06235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5093_06240	COG1024	Enoyl-CoA hydratase
E5093_06245	COG1024	Enoyl-CoA hydratase
E5093_06250	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_06255	COG0183	Belongs to the thiolase family
E5093_06260	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5093_06265	COG3327	negative regulation of DNA-templated transcription, initiation
E5093_06275	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_06295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E5093_06300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5093_06300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5093_06305	COG1254	Belongs to the acylphosphatase family
E5093_06340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5093_06345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5093_06355	COG2353	YceI-like domain
E5093_06360	COG0519	Catalyzes the synthesis of GMP from XMP
E5093_06360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5093_06390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5093_06395	COG0583	DNA-binding transcription factor activity
E5093_06405	COG2707	UPF0756 membrane protein
E5093_06430	COG0802	atpase or kinase
E5093_06435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5093_06445	COG1923	regulation of RNA biosynthetic process
E5093_06450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5093_06460	COG3178	'Phosphotransferase
E5093_06465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5093_06475	COG1192	Involved in chromosome partitioning
E5093_06480	COG1475	DNA binding
E5093_06485	COG0811	peptide transport
E5093_06495	COG1132	(ABC) transporter
E5093_06500	COG1663	tetraacyldisaccharide 4'-kinase activity
E5093_06520	COG0084	hydrolase, TatD family'
E5093_06555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E5093_06585	COG0776	regulation of translation
E5093_06595	COG0284	orotidine-5'-phosphate decarboxylase activity
E5093_06600	COG2431	L-lysine efflux transmembrane transporter activity
E5093_06615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5093_06620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5093_06640	COG1253	flavin adenine dinucleotide binding
E5093_06670	COG0583	DNA-binding transcription factor activity
E5093_06685	COG3852	Histidine kinase
E5093_06700	COG0233	cytoplasmic translational termination
E5093_06705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5093_06710	COG0575	Belongs to the CDS family
E5093_06745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5093_06775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5093_06785	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5093_06790	COG2207	Transcriptional regulator
E5093_06795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5093_06805	COG1960	acyl-CoA dehydrogenase activity
E5093_06810	COG1960	acyl-CoA dehydrogenase activity
E5093_06845	COG4890	Cyd operon protein YbgT
E5093_06850	COG1294	oxidase, subunit
E5093_06865	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5093_06875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5093_06895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5093_06900	COG0569	domain protein
E5093_06910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5093_06930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5093_06935	COG0542	response to heat
E5093_06970	COG0372	Belongs to the citrate synthase family
E5093_06980	COG1058	Belongs to the CinA family
E5093_06980	COG1546	Belongs to the CinA family
E5093_07015	COG2814	Major facilitator Superfamily
E5093_07030	COG0439	Biotin carboxylase
E5093_07035	COG0511	ligase activity, forming carbon-carbon bonds
E5093_07070	COG0596	Alpha beta hydrolase
E5093_07160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5093_07165	COG1012	belongs to the aldehyde dehydrogenase family
E5093_07175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E5093_07180	COG1012	belongs to the aldehyde dehydrogenase family
E5093_07185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5093_07190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_07195	COG2267	carboxylic ester hydrolase activity
E5093_07220	COG0730	response to heat
E5093_07225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_07230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5093_07245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5093_07255	COG0745	RESPONSE REGULATOR receiver
E5093_07275	COG1012	belongs to the aldehyde dehydrogenase family
E5093_07280	COG1309	transcriptional regulator
E5093_07285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5093_07320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5093_07350	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_07360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E5093_07365	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_07370	COG1846	Transcriptional regulator
E5093_07375	COG2814	Major facilitator Superfamily
E5093_07390	COG0318	PFAM AMP-dependent synthetase and ligase
E5093_07395	COG3293	Transposase
E5093_07405	COG2814	Major facilitator Superfamily
E5093_07410	COG2814	Major facilitator Superfamily
E5093_07420	COG1073	alpha beta
E5093_07420	COG2226	methyltransferase
E5093_07425	COG1960	acyl-CoA dehydrogenase activity
E5093_07435	COG1024	Enoyl-CoA hydratase
E5093_07440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5093_07445	COG0235	Class ii aldolase
E5093_07455	COG0183	Belongs to the thiolase family
E5093_07460	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5093_07465	COG1024	Enoyl-CoA hydratase
E5093_07470	COG2814	Major facilitator Superfamily
E5093_07480	COG2814	Major facilitator Superfamily
E5093_07490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_07495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5093_07500	COG2814	Major facilitator Superfamily
E5093_07505	COG1960	acyl-CoA dehydrogenase activity
E5093_07510	COG1960	acyl-CoA dehydrogenase activity
E5093_07520	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5093_07520	COG0644	oxidoreductase
E5093_07525	COG0515	serine threonine protein kinase
E5093_07530	COG2116	formate transmembrane transporter activity
E5093_07535	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E5093_07545	COG2223	nitrite transmembrane transporter activity
E5093_07555	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_07585	COG2814	Major facilitator Superfamily
E5093_07590	COG0583	DNA-binding transcription factor activity
E5093_07595	COG4948	Mandelate Racemase Muconate Lactonizing
E5093_07600	COG4829	muconolactone delta-isomerase
E5093_07610	COG4638	Rieske (2fe-2S)
E5093_07615	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5093_07620	COG0543	2 iron, 2 sulfur cluster binding
E5093_07620	COG0633	Ferredoxin
E5093_07625	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_07630	COG3135	benzoate transporter
E5093_07635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5093_07640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5093_07645	COG0183	Belongs to the thiolase family
E5093_07650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_07670	COG0583	DNA-binding transcription factor activity
E5093_07675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5093_07680	COG4149	molybdate abc transporter
E5093_07685	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5093_07690	COG0303	'Molybdopterin
E5093_07695	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5093_07695	COG0315	cyclic pyranopterin monophosphate synthase activity
E5093_07710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5093_07720	COG0243	molybdopterin cofactor binding
E5093_07725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_07730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_07735	COG2223	nitrite transmembrane transporter activity
E5093_07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5093_07745	COG1116	anion transmembrane transporter activity
E5093_07750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5093_07755	COG2937	Belongs to the GPAT DAPAT family
E5093_07760	COG0640	Transcriptional regulator
E5093_07780	COG3122	Protein conserved in bacteria
E5093_07785	COG0668	transmembrane transport
E5093_07800	COG1132	(ABC) transporter
E5093_07820	COG2814	Major facilitator Superfamily
E5093_07830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5093_07840	COG1113	amino acid transport
E5093_07855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5093_07860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5093_07910	COG1525	nuclease
E5093_07920	COG1294	oxidase, subunit
E5093_07925	COG1271	oxidase subunit
E5093_07935	COG2814	Major facilitator Superfamily
E5093_07940	COG2207	Transcriptional regulator
E5093_07945	COG1960	acyl-CoA dehydrogenase activity
E5093_07960	COG1629	transport
E5093_07975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5093_07980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E5093_08000	COG0583	DNA-binding transcription factor activity
E5093_08010	COG1346	cytolysis
E5093_08020	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5093_08030	COG0693	protein deglycase activity
E5093_08075	COG0552	protein localization to endoplasmic reticulum
E5093_08080	COG0612	Peptidase, M16
E5093_08110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5093_08110	COG0617	tRNA 3'-terminal CCA addition
E5093_08110	COG0517	IMP dehydrogenase activity
E5093_08115	COG0133	tryptophan synthase activity
E5093_08125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5093_08145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5093_08200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5093_08230	COG0822	iron-sulfur transferase activity
E5093_08235	COG0316	Belongs to the HesB IscA family
E5093_08265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5093_08280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5093_08285	COG0702	epimerase
E5093_08290	COG0268	Binds directly to 16S ribosomal RNA
E5093_08310	COG1011	Hydrolase
E5093_08315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5093_08325	COG2137	regulation of response to DNA damage stimulus
E5093_08340	COG0772	Belongs to the SEDS family
E5093_08355	COG0148	phosphopyruvate hydratase activity
E5093_08385	COG1902	pentaerythritol trinitrate reductase activity
E5093_08385	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5093_08400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5093_08410	COG3293	Transposase
E5093_08415	COG1960	acyl-CoA dehydrogenase activity
E5093_08420	COG0583	DNA-binding transcription factor activity
E5093_08425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5093_08430	COG1027	Aspartate ammonia-lyase
E5093_08435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5093_08445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5093_08445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5093_08445	COG0506	proline dehydrogenase activity
E5093_08465	COG3698	Phosphodiester glycosidase
E5093_08505	COG0697	spore germination
E5093_08530	COG0424	maF-like protein
E5093_08535	COG2850	peptidyl-arginine hydroxylation
E5093_08540	COG4585	Histidine kinase
E5093_08550	COG0069	glutamate synthase activity
E5093_08570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5093_08575	COG1454	alcohol dehydrogenase
E5093_08580	COG0824	Thioesterase
E5093_08585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5093_08600	COG2030	dehydratase
E5093_08610	COG0183	Belongs to the thiolase family
E5093_08625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5093_08635	COG3135	benzoate transporter
E5093_08645	COG0589	response to stress
E5093_08650	COG0589	response to stress
E5093_08660	COG0308	aminopeptidase N
E5093_08690	COG0786	glutamate:sodium symporter activity
E5093_08735	COG0477	Major facilitator Superfamily
E5093_08750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5093_08760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5093_08770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5093_08775	COG1960	acyl-CoA dehydrogenase activity
E5093_08795	COG3781	membrane
E5093_08800	COG2890	protein-(glutamine-N5) methyltransferase activity
E5093_08805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5093_08820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5093_08845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5093_08850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5093_08855	COG1845	cytochrome c oxidase, subunit III
E5093_08860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5093_08870	COG0360	Binds together with S18 to 16S ribosomal RNA
E5093_08875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5093_08890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5093_08905	COG1305	Transglutaminase-like
E5093_08915	COG2308	Evidence 4 Homologs of previously reported genes of
E5093_08955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5093_08960	COG0138	bifunctional purine biosynthesis protein purh
E5093_08980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5093_08985	COG2011	ABC-type metal ion transport system permease component
E5093_09025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5093_09035	COG4122	O-methyltransferase activity
E5093_09060	COG2274	protein secretion by the type I secretion system
E5093_09070	COG1137	ATPase activity
E5093_09075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5093_09085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5093_09090	COG0517	IMP dehydrogenase activity
E5093_09090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5093_09115	COG1643	Atp-dependent helicase
E5093_09145	COG3634	alkyl hydroperoxide reductase activity
E5093_09155	COG2391	methyltransferase activity
E5093_09180	COG2070	2-Nitropropane dioxygenase
E5093_09195	COG1278	Cold shock
E5093_09260	COG1309	transcriptional regulator
E5093_09265	COG0596	Alpha beta hydrolase
E5093_09305	COG0352	thiamine-phosphate diphosphorylase activity
E5093_09340	COG0612	Peptidase, M16
E5093_09350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_09360	COG0739	heme binding
E5093_09370	COG1187	pseudouridine synthase activity
E5093_09385	COG1686	Belongs to the peptidase S11 family
E5093_09390	COG1252	NADH dehydrogenase
E5093_09395	COG1047	Peptidyl-prolyl cis-trans
E5093_09420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5093_09425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5093_09440	COG0693	protein deglycase activity
E5093_09445	COG1960	acyl-CoA dehydrogenase activity
E5093_09450	COG1301	dicarboxylic acid transport
E5093_09460	COG3139	Protein of unknown function (DUF1315)
E5093_09465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5093_09470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5093_09490	COG0642	Histidine kinase
E5093_09495	COG0745	RESPONSE REGULATOR receiver
E5093_09505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E5093_09515	COG1720	tRNA m6t6A37 methyltransferase activity
E5093_09530	COG0789	Transcriptional regulator
E5093_09535	COG0431	NADPH-dependent FMN reductase
E5093_09540	COG0798	PFAM Bile acid sodium symporter
E5093_09550	COG0640	Transcriptional regulator
E5093_09565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5093_09570	COG3634	alkyl hydroperoxide reductase activity
E5093_09590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5093_09595	COG3385	transposase activity
E5093_09765	COG3728	DNA packaging
E5093_09765	COG5484	DNA packaging
E5093_09820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5093_09915	COG1131	(ABC) transporter
E5093_09920	COG0842	Transport permease protein
E5093_09935	COG2951	lytic endotransglycosylase activity
E5093_09960	COG0052	Belongs to the universal ribosomal protein uS2 family
E5093_09980	COG2175	clavaminate synthase activity
E5093_09990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5093_10020	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5093_10025	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5093_10030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5093_10050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E5093_10080	COG2871	sodium ion transport
E5093_10100	COG0582	viral genome integration into host DNA
E5093_10130	COG2223	nitrite transmembrane transporter activity
E5093_10205	COG0798	PFAM Bile acid sodium symporter
E5093_10215	COG0640	Transcriptional regulator
E5093_10240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5093_10315	COG0789	Transcriptional regulator
E5093_10370	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5093_10370	COG1902	pentaerythritol trinitrate reductase activity
E5093_10385	COG5001	Diguanylate cyclase
E5093_10385	COG2203	Gaf domain
E5093_10385	COG3706	GGDEF domain
E5093_10385	COG4251	negative regulation of phosphorylation
E5093_10390	COG0418	dihydroorotase activity
E5093_10395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5093_10415	COG0833	amino acid
E5093_10445	COG4172	Belongs to the ABC transporter superfamily
E5093_10450	COG4239	(ABC) transporter, permease
E5093_10455	COG4174	ABC transporter (Permease)
E5093_10460	COG4166	transmembrane transport
E5093_10465	COG1388	LysM domain
E5093_10465	COG0741	lytic transglycosylase activity
E5093_10480	COG2816	NAD+ diphosphatase activity
E5093_10515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5093_10520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5093_10530	COG0006	proline dipeptidase activity
E5093_10535	COG3079	Belongs to the UPF0149 family
E5093_10570	COG0277	FAD linked oxidase domain protein
E5093_10580	COG2186	Transcriptional regulator
E5093_10600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5093_10610	COG2234	aminopeptidase activity
E5093_10620	COG3384	dioxygenase
E5093_10630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5093_10635	COG2878	Part of a membrane complex involved in electron transport
E5093_10640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5093_10665	COG0768	penicillin binding
E5093_10670	COG0742	ribosomal rna small subunit methyltransferase
E5093_10685	COG0830	nickel cation binding
E5093_10700	COG0804	urea catabolic process
E5093_10720	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_10735	COG3015	lipoprotein NlpE involved in copper resistance
E5093_10755	COG1253	flavin adenine dinucleotide binding
E5093_10775	COG3118	belongs to the thioredoxin family
E5093_10810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5093_10815	COG1773	rubredoxin
E5093_10820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5093_10830	COG0583	DNA-binding transcription factor activity
E5093_10840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5093_10850	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5093_10855	COG4181	ATPase activity
E5093_10880	COG4771	TonB-dependent receptor
E5093_10905	COG0306	phosphate transporter
E5093_10930	COG2852	Protein conserved in bacteria
E5093_10935	COG2066	Belongs to the glutaminase family
E5093_10945	COG0477	Major facilitator Superfamily
E5093_10975	COG2199	diguanylate cyclase activity
E5093_10975	COG2203	Gaf domain
E5093_10985	COG4681	YaeQ
E5093_10990	COG0523	cobalamin synthesis protein
E5093_11010	COG0583	DNA-binding transcription factor activity
E5093_11015	COG2814	Major facilitator Superfamily
E5093_11025	COG1607	acyl-coa hydrolase
E5093_11035	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5093_11040	COG2059	Chromate
E5093_11045	COG1115	amino acid carrier protein
E5093_11050	COG0786	glutamate:sodium symporter activity
E5093_11065	COG2814	Major facilitator Superfamily
E5093_11070	COG1289	transmembrane transporter activity
E5093_11080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E5093_11135	COG1376	ErfK ybiS ycfS ynhG family protein
E5093_11140	COG2832	Protein of unknown function (DUF454)
E5093_11150	COG5510	response to toxic substance
E5093_11165	COG0643	Histidine kinase
E5093_11165	COG0784	Response regulator, receiver
E5093_11165	COG2198	Histidine kinase
E5093_11170	COG0840	transmembrane signaling receptor activity
E5093_11205	COG0442	prolyl-tRNA aminoacylation
E5093_11240	COG2358	TRAP transporter, solute receptor (TAXI family
E5093_11255	COG0489	protein tyrosine kinase activity
E5093_11260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5093_11260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5093_11275	COG0004	ammonium transporteR
E5093_11290	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5093_11305	COG2081	HI0933 family
E5093_11315	COG0668	transmembrane transport
E5093_11340	COG0583	DNA-binding transcription factor activity
E5093_11345	COG1278	Cold shock
E5093_11350	COG1278	Cold shock
E5093_11365	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5093_11370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5093_11375	COG0713	ATP synthesis coupled electron transport
E5093_11380	COG0839	Belongs to the complex I subunit 6 family
E5093_11385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5093_11390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E5093_11400	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5093_11420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5093_11430	COG0142	geranyltranstransferase activity
E5093_11435	COG2828	Protein conserved in bacteria
E5093_11440	COG1113	amino acid transport
E5093_11460	COG0625	glutathione transferase activity
E5093_11500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5093_11510	COG1530	ribonuclease E activity
E5093_11515	COG0424	maF-like protein
E5093_11520	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5093_11525	COG1792	Involved in formation and maintenance of cell shape
E5093_11530	COG1077	Cell shape determining protein MreB Mrl
E5093_11535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5093_11540	COG0154	amidase activity
E5093_11545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5093_11580	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E5093_11595	COG1215	transferase activity, transferring glycosyl groups
E5093_11600	COG0726	polysaccharide deacetylase
E5093_11600	COG1649	PFAM Uncharacterised BCR, COG1649
E5093_11625	COG3177	Filamentation induced by cAMP protein fic
E5093_11640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5093_11645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5093_11670	COG0640	Transcriptional regulator
E5093_11685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E5093_11695	COG0745	RESPONSE REGULATOR receiver
E5093_11700	COG0642	Histidine kinase
E5093_11710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5093_11795	COG0582	viral genome integration into host DNA
E5093_11805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5093_11810	COG2050	protein possibly involved in aromatic compounds catabolism
E5093_11830	COG0420	3'-5' exonuclease activity
E5093_11860	COG0735	belongs to the Fur family
E5093_11865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5093_11870	COG2914	Belongs to the UPF0125 (RnfH) family
E5093_11885	COG0121	glutamine amidotransferase
E5093_11900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5093_11910	COG0210	DNA helicase
E5093_11915	COG2885	chlorophyll binding
E5093_11920	COG0204	Acyl-transferase
E5093_11930	COG0850	regulation of cytokinetic process
E5093_11935	COG2894	cell division
E5093_11950	COG1674	ftsk spoiiie
E5093_11950	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E5093_11955	COG0492	ferredoxin-NADP+ reductase activity
E5093_11960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5093_11970	COG0456	acetyltransferase
E5093_11995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5093_12015	COG1113	amino acid transport
E5093_12020	COG0251	oxidation-reduction process
E5093_12045	COG0351	phosphomethylpyrimidine kinase
E5093_12045	COG0352	thiamine-phosphate diphosphorylase activity
E5093_12045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5093_12060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5093_12075	COG2132	Multicopper oxidase
E5093_12085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5093_12100	COG4269	membrane
E5093_12120	COG1968	undecaprenyl-diphosphatase activity
E5093_12125	COG1214	PFAM Peptidase M22, glycoprotease
E5093_12135	COG0494	nUDIX hydrolase
E5093_12185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5093_12190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5093_12250	COG2199	diguanylate cyclase activity
E5093_12255	COG2885	chlorophyll binding
E5093_12280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5093_12285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5093_12305	COG0450	alkyl hydroperoxide reductase
E5093_12320	COG0285	dihydrofolate synthase activity
E5093_12325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E5093_12370	COG4206	TonB-dependent receptor
E5093_12375	COG2096	Adenosyltransferase
E5093_12395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5093_12400	COG2315	Protein conserved in bacteria
E5093_12410	COG0745	RESPONSE REGULATOR receiver
E5093_12415	COG2205	protein histidine kinase activity
E5093_12425	COG1960	acyl-CoA dehydrogenase activity
E5093_12430	COG1960	acyl-CoA dehydrogenase activity
E5093_12435	COG3223	Belongs to the PsiE family
E5093_12470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5093_12500	COG0463	Glycosyl transferase, family 2
E5093_12520	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5093_12525	COG5002	protein histidine kinase activity
E5093_12535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5093_12545	COG0732	type I restriction modification DNA specificity domain
E5093_12550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5093_12565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5093_12575	COG2026	Addiction module toxin, RelE StbE family
E5093_12585	COG0415	Belongs to the DNA photolyase family
E5093_12620	COG0582	viral genome integration into host DNA
E5093_12630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5093_12640	COG1704	LemA family
E5093_12645	COG4251	negative regulation of phosphorylation
E5093_12645	COG3706	GGDEF domain
E5093_12645	COG2203	Gaf domain
E5093_12645	COG5001	Diguanylate cyclase
E5093_12660	COG1862	Preprotein translocase
E5093_12680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5093_12695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5093_12700	COG0784	Response regulator, receiver
E5093_12700	COG2205	protein histidine kinase activity
E5093_12700	COG5002	protein histidine kinase activity
E5093_12705	COG1024	Enoyl-CoA hydratase
E5093_12715	COG3622	Belongs to the hyi family
E5093_12745	COG0697	spore germination
E5093_12750	COG2814	Major facilitator Superfamily
E5093_12790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E5093_12800	COG0732	type I restriction modification DNA specificity domain
E5093_12810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E5093_12830	COG0174	glutamine synthetase
E5093_12845	COG0745	RESPONSE REGULATOR receiver
E5093_12850	COG2205	protein histidine kinase activity
E5093_12860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5093_12865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5093_12945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5093_12950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5093_12955	COG0084	hydrolase, TatD family'
E5093_12970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5093_12985	COG0793	Belongs to the peptidase S41A family
E5093_13015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5093_13020	COG0857	belongs to the CobB CobQ family
E5093_13020	COG0280	phosphate acetyltransferase
E5093_13045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5093_13045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5093_13060	COG0740	serine-type endopeptidase activity
E5093_13070	COG4771	TonB-dependent receptor
E5093_13075	COG4774	siderophore transport
E5093_13080	COG3128	pkhd-type hydroxylase
E5093_13090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5093_13095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_13100	COG2813	Specifically methylates the guanine in position
E5093_13100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5093_13160	COG3040	lipid binding
E5093_13225	COG3040	lipid binding
E5093_13255	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5093_13295	COG0557	exoribonuclease II activity
E5093_13305	COG0339	signal peptide processing
E5093_13310	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5093_13320	COG0697	spore germination
E5093_13325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5093_13350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5093_13355	COG1960	acyl-CoA dehydrogenase activity
E5093_13360	COG2072	flavoprotein involved in K transport
E5093_13370	COG0202	RNA polymerase activity
E5093_13375	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5093_13410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5093_13420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5093_13425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5093_13460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5093_13490	COG0088	Forms part of the polypeptide exit tunnel
E5093_13515	COG0433	COG0433 Predicted ATPase
E5093_13525	COG1959	2 iron, 2 sulfur cluster binding
E5093_13545	COG1301	dicarboxylic acid transport
E5093_13550	COG1946	Acyl-CoA thioesterase
E5093_13555	COG2937	Belongs to the GPAT DAPAT family
E5093_13565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5093_13570	COG1040	competence protein
E5093_13585	COG0598	Magnesium transport protein CorA
E5093_13595	COG2854	intermembrane phospholipid transfer
E5093_13600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5093_13605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5093_13610	COG1127	ABC transporter
E5093_13635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5093_13655	COG1960	acyl-CoA dehydrogenase activity
E5093_13660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5093_13670	COG0534	Mate efflux family protein
E5093_13675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5093_13680	COG0254	rRNA binding
E5093_13685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E5093_13705	COG2226	methyltransferase
E5093_13720	COG1192	Involved in chromosome partitioning
E5093_13725	COG0628	permease
E5093_13735	COG2814	Major facilitator Superfamily
E5093_13750	COG0277	FAD linked oxidase domain protein
E5093_13755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5093_13780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5093_13785	COG5380	lipid catabolic process
E5093_13805	COG0335	large ribosomal subunit rRNA binding
E5093_13815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5093_13820	COG0228	four-way junction DNA binding
E5093_13855	COG4969	Belongs to the N-Me-Phe pilin family
E5093_13865	COG0194	GDP metabolic process
E5093_13870	COG1758	RNA polymerase activity
E5093_13875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5093_13895	COG3307	-O-antigen
E5093_13910	COG4969	Belongs to the N-Me-Phe pilin family
E5093_13920	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E5093_13925	COG1704	LemA family
E5093_13935	COG0493	'glutamate synthase
E5093_13940	COG0070	glutamate synthase
E5093_13940	COG0067	glutamate synthase
E5093_13940	COG0069	glutamate synthase activity
E5093_14000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5093_14005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5093_14020	COG0275	rRNA processing
E5093_14025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5093_14035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5093_14055	COG0488	(ABC) transporter
E5093_14065	COG4221	oxidoreductase activity
E5093_14090	COG0745	RESPONSE REGULATOR receiver
E5093_14095	COG2205	protein histidine kinase activity
E5093_14100	COG0427	acetyl-CoA hydrolase
E5093_14130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5093_14150	COG0697	spore germination
E5093_14165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5093_14205	COG3158	transport of potassium into the cell
E5093_14230	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E5093_14260	COG3077	Addiction module antitoxin, RelB DinJ family
E5093_14275	COG2132	Multicopper oxidase
E5093_14290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5093_14335	COG2132	Multicopper oxidase
E5093_14350	COG2205	protein histidine kinase activity
E5093_14355	COG3174	membrane
E5093_14360	COG2217	Heavy metal translocating P-type atpase
E5093_14465	COG0629	single-stranded DNA binding
E5093_14470	COG2814	Major facilitator Superfamily
E5093_14480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5093_14485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5093_14490	COG3706	GGDEF domain
E5093_14500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5093_14520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5093_14525	COG3162	membrane
E5093_14530	COG2205	protein histidine kinase activity
E5093_14530	COG0784	Response regulator, receiver
E5093_14545	COG0431	NADPH-dependent FMN reductase
E5093_14560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5093_14565	COG0668	transmembrane transport
E5093_14570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5093_14575	COG1519	Transferase
E5093_14580	COG1902	pentaerythritol trinitrate reductase activity
E5093_14585	COG0640	Transcriptional regulator
E5093_14605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5093_14630	COG0426	domain, Protein
E5093_14630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5093_14635	COG2119	membrane
E5093_14665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5093_14675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5093_14685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5093_14690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5093_14695	COG0189	ligase activity
E5093_14700	COG0386	Belongs to the glutathione peroxidase family
E5093_14705	COG1846	Transcriptional regulator
E5093_14720	COG0708	Exodeoxyribonuclease III
E5093_14725	COG1393	Belongs to the ArsC family
E5093_14740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5093_14745	COG3706	GGDEF domain
E5093_14750	COG0625	glutathione transferase activity
E5093_14790	COG1247	-acetyltransferase
E5093_14795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5093_14805	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E5093_14815	COG0471	metal ion transport
E5093_14855	COG3150	esterase
E5093_14865	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E5093_14870	COG2918	glutathione biosynthetic process
E5093_14885	COG2733	membrane
E5093_14890	COG0436	Aminotransferase
E5093_14895	COG0534	Mate efflux family protein
E5093_14900	COG2175	clavaminate synthase activity
E5093_14945	COG0753	catalase activity
E5093_14965	COG0560	Phosphoserine phosphatase
E5093_14965	COG3830	Belongs to the UPF0237 family
E5093_14980	COG0385	Bile acid
E5093_14985	COG1335	isochorismatase
E5093_14990	COG2814	Major facilitator Superfamily
E5093_14995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5093_15005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5093_15010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5093_15015	COG2983	Belongs to the UPF0260 family
E5093_15020	COG5487	UPF0391 membrane protein
E5093_15035	COG1194	a g-specific adenine glycosylase
E5093_15040	COG0739	heme binding
E5093_15050	COG2818	Glycosylase
E5093_15055	COG1064	alcohol dehydrogenase
E5093_15075	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5093_15085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E5093_15090	COG1309	transcriptional regulator
E5093_15100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5093_15105	COG0546	phosphoglycolate phosphatase activity
E5093_15110	COG1028	Short-chain dehydrogenase reductase Sdr
E5093_15130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5093_15130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E5093_15135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5093_15140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5093_15145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5093_15150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5093_15155	COG1116	anion transmembrane transporter activity
E5093_15160	COG1309	transcriptional regulator
E5093_15170	COG0196	riboflavin kinase activity
E5093_15175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5093_15180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E5093_15185	COG1047	Peptidyl-prolyl cis-trans
E5093_15195	COG2133	pyrroloquinoline quinone binding
E5093_15200	COG2814	Major facilitator Superfamily
E5093_15230	COG0737	Belongs to the 5'-nucleotidase family
E5093_15240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5093_15245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5093_15270	COG0488	(ABC) transporter
E5093_15275	COG1063	alcohol dehydrogenase
E5093_15280	COG0187	DNA topoisomerase II activity
E5093_15290	COG0592	DNA-directed DNA polymerase activity