locus-tag	class	description
LCH18_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LCH18_00010	COG0592	DNA-directed DNA polymerase activity
LCH18_00020	COG0187	DNA topoisomerase II activity
LCH18_00030	COG0488	(ABC) transporter
LCH18_00090	COG0657	acetylesterase activity
LCH18_00100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LCH18_00130	COG2814	Major facilitator Superfamily
LCH18_00145	COG0733	neurotransmitter:sodium symporter activity
LCH18_00165	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LCH18_00165	COG3266	domain, Protein
LCH18_00165	COG4932	domain protein
LCH18_00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCH18_00180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCH18_00195	COG0129	dihydroxy-acid dehydratase activity
LCH18_00205	COG4774	siderophore transport
LCH18_00215	COG0583	DNA-binding transcription factor activity
LCH18_00220	COG2233	PERMEase
LCH18_00230	COG1309	transcriptional regulator
LCH18_00260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LCH18_00275	COG0436	Aminotransferase
LCH18_00280	COG1064	alcohol dehydrogenase
LCH18_00285	COG2818	Glycosylase
LCH18_00315	COG5487	UPF0391 membrane protein
LCH18_00320	COG2983	Belongs to the UPF0260 family
LCH18_00325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LCH18_00345	COG4160	amino acid transport
LCH18_00350	COG4215	(ABC) transporter
LCH18_00380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LCH18_00385	COG1335	isochorismatase
LCH18_00390	COG0385	Bile acid
LCH18_00465	COG0534	Mate efflux family protein
LCH18_00470	COG0436	Aminotransferase
LCH18_00475	COG2733	membrane
LCH18_00495	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LCH18_00505	COG3150	esterase
LCH18_00590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LCH18_00605	COG1393	Belongs to the ArsC family
LCH18_00610	COG0708	Exodeoxyribonuclease III
LCH18_00620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LCH18_00635	COG1846	Transcriptional regulator
LCH18_00640	COG0386	Belongs to the glutathione peroxidase family
LCH18_00645	COG0189	ligase activity
LCH18_00655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCH18_00665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LCH18_00675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LCH18_00700	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCH18_00705	COG2119	membrane
LCH18_00710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCH18_00710	COG0426	domain, Protein
LCH18_00735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LCH18_00760	COG1902	pentaerythritol trinitrate reductase activity
LCH18_00765	COG1519	Transferase
LCH18_00770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LCH18_00775	COG0668	transmembrane transport
LCH18_00780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCH18_00785	COG0307	riboflavin synthase, alpha
LCH18_00790	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_00805	COG0431	NADPH-dependent FMN reductase
LCH18_00820	COG0784	Response regulator, receiver
LCH18_00820	COG2205	protein histidine kinase activity
LCH18_00825	COG3162	membrane
LCH18_00830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCH18_00840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LCH18_00850	COG3706	GGDEF domain
LCH18_00870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LCH18_00870	COG0352	thiamine-phosphate diphosphorylase activity
LCH18_00870	COG0351	phosphomethylpyrimidine kinase
LCH18_00880	COG2814	Major facilitator Superfamily
LCH18_00885	COG0629	single-stranded DNA binding
LCH18_00895	COG0583	DNA-binding transcription factor activity
LCH18_00900	COG1301	dicarboxylic acid transport
LCH18_00915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCH18_00940	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
LCH18_00965	COG3158	transport of potassium into the cell
LCH18_00985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LCH18_01010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LCH18_01015	COG1278	Cold shock
LCH18_01030	COG0531	amino acid
LCH18_01035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH18_01065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LCH18_01100	COG0427	acetyl-CoA hydrolase
LCH18_01125	COG4221	oxidoreductase activity
LCH18_01130	COG2873	o-acetylhomoserine
LCH18_01135	COG0488	(ABC) transporter
LCH18_01155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCH18_01170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LCH18_01190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LCH18_01195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LCH18_01205	COG2226	methyltransferase
LCH18_01255	COG0070	glutamate synthase
LCH18_01255	COG0069	glutamate synthase activity
LCH18_01255	COG0067	glutamate synthase
LCH18_01260	COG0493	'glutamate synthase
LCH18_01270	COG1704	LemA family
LCH18_01275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LCH18_01295	COG0463	Glycosyl transferase, family 2
LCH18_01300	COG1132	(ABC) transporter
LCH18_01330	COG0438	transferase activity, transferring glycosyl groups
LCH18_01335	COG0297	glycogen (starch) synthase activity
LCH18_01340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LCH18_01340	COG2755	lipolytic protein G-D-S-L family
LCH18_01370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCH18_01375	COG1758	RNA polymerase activity
LCH18_01380	COG0194	GDP metabolic process
LCH18_01425	COG0228	four-way junction DNA binding
LCH18_01430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LCH18_01440	COG0335	large ribosomal subunit rRNA binding
LCH18_01450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LCH18_01455	COG5380	lipid catabolic process
LCH18_01460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LCH18_01480	COG5006	permease, DMT superfamily
LCH18_01485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LCH18_01490	COG0277	FAD linked oxidase domain protein
LCH18_01500	COG2197	response regulator
LCH18_01505	COG0477	Major facilitator Superfamily
LCH18_01515	COG2814	Major facilitator Superfamily
LCH18_01520	COG1289	transmembrane transporter activity
LCH18_01525	COG2032	superoxide dismutase activity
LCH18_01530	COG0628	permease
LCH18_01535	COG1192	Involved in chromosome partitioning
LCH18_01545	COG2226	methyltransferase
LCH18_01560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LCH18_01565	COG0254	rRNA binding
LCH18_01570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LCH18_01580	COG0534	Mate efflux family protein
LCH18_01590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCH18_01610	COG1910	domain protein
LCH18_01635	COG1960	acyl-CoA dehydrogenase activity
LCH18_01655	COG0408	coproporphyrinogen oxidase activity
LCH18_01660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCH18_01670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LCH18_01680	COG0513	Belongs to the DEAD box helicase family
LCH18_01685	COG1127	ABC transporter
LCH18_01690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LCH18_01695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LCH18_01700	COG2854	intermembrane phospholipid transfer
LCH18_01710	COG0598	Magnesium transport protein CorA
LCH18_01725	COG1040	competence protein
LCH18_01730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LCH18_01750	COG2937	Belongs to the GPAT DAPAT family
LCH18_01755	COG1946	Acyl-CoA thioesterase
LCH18_01760	COG1301	dicarboxylic acid transport
LCH18_01775	COG1959	2 iron, 2 sulfur cluster binding
LCH18_01785	COG0433	COG0433 Predicted ATPase
LCH18_01805	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LCH18_01810	COG0088	Forms part of the polypeptide exit tunnel
LCH18_01825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LCH18_01875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LCH18_01880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LCH18_01890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LCH18_01915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LCH18_01930	COG0202	RNA polymerase activity
LCH18_01935	COG0203	ribosomal protein L17
LCH18_01940	COG2072	flavoprotein involved in K transport
LCH18_01950	COG1960	acyl-CoA dehydrogenase activity
LCH18_01955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LCH18_01985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LCH18_01990	COG0339	signal peptide processing
LCH18_01995	COG2720	vancomycin resistance protein
LCH18_02000	COG0557	exoribonuclease II activity
LCH18_02030	COG0179	Fumarylacetoacetate (FAA) hydrolase
LCH18_02045	COG1295	ribonuclease BN
LCH18_02090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LCH18_02095	COG1702	phosphate starvation-inducible protein PhoH
LCH18_02100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCH18_02105	COG0739	heme binding
LCH18_02105	COG0741	lytic transglycosylase activity
LCH18_02105	COG1196	nuclear chromosome segregation
LCH18_02115	COG0039	L-malate dehydrogenase activity
LCH18_02140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LCH18_02145	COG1183	phosphatidylcholine synthase activity
LCH18_02205	COG1607	acyl-coa hydrolase
LCH18_02220	COG1666	GTP binding
LCH18_02240	COG2350	Protein conserved in bacteria
LCH18_02250	COG0613	PHP domain protein
LCH18_02255	COG3781	membrane
LCH18_02265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LCH18_02290	COG1162	GTPase activity
LCH18_02295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LCH18_02310	COG1538	Outer membrane efflux protein
LCH18_02315	COG0577	efflux transmembrane transporter activity
LCH18_02315	COG1136	(ABC) transporter
LCH18_02320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH18_02345	COG0028	Belongs to the TPP enzyme family
LCH18_02350	COG0440	acetolactate synthase activity
LCH18_02410	COG1426	Protein conserved in bacteria
LCH18_02430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCH18_02455	COG1862	Preprotein translocase
LCH18_02465	COG1704	LemA family
LCH18_02475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LCH18_02485	COG5002	protein histidine kinase activity
LCH18_02490	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LCH18_02520	COG0438	transferase activity, transferring glycosyl groups
LCH18_02565	COG1215	transferase activity, transferring glycosyl groups
LCH18_02580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LCH18_02610	COG3223	Belongs to the PsiE family
LCH18_02615	COG1960	acyl-CoA dehydrogenase activity
LCH18_02620	COG1960	acyl-CoA dehydrogenase activity
LCH18_02630	COG2205	protein histidine kinase activity
LCH18_02635	COG0745	RESPONSE REGULATOR receiver
LCH18_02640	COG1113	amino acid transport
LCH18_02645	COG2315	Protein conserved in bacteria
LCH18_02650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LCH18_02670	COG2096	Adenosyltransferase
LCH18_02675	COG4206	TonB-dependent receptor
LCH18_02725	COG0285	dihydrofolate synthase activity
LCH18_02745	COG0450	alkyl hydroperoxide reductase
LCH18_02765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LCH18_02770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LCH18_02800	COG2199	diguanylate cyclase activity
LCH18_02860	COG2969	positive regulation of protein catabolic process
LCH18_02865	COG0625	glutathione transferase activity
LCH18_02875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LCH18_02880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LCH18_02885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LCH18_02890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LCH18_02895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LCH18_02920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LCH18_02930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCH18_02935	COG1408	metallophosphoesterase
LCH18_02945	COG0477	Major facilitator Superfamily
LCH18_02950	COG1272	protein, Hemolysin III
LCH18_02970	COG1024	Enoyl-CoA hydratase
LCH18_02970	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCH18_02975	COG0183	Belongs to the thiolase family
LCH18_02980	COG2207	Transcriptional regulator
LCH18_02985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LCH18_03000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCH18_03020	COG0183	Belongs to the thiolase family
LCH18_03035	COG0833	amino acid
LCH18_03045	COG2233	PERMEase
LCH18_03050	COG1217	gtp-binding protein TYPA
LCH18_03060	COG1970	mechanosensitive ion channel activity
LCH18_03070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH18_03080	COG3659	wide pore channel activity
LCH18_03085	COG1902	pentaerythritol trinitrate reductase activity
LCH18_03120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LCH18_03165	COG0346	lactoylglutathione lyase activity
LCH18_03170	COG0564	pseudouridine synthase activity
LCH18_03190	COG3189	MarR family transcriptional regulator
LCH18_03195	COG2824	Alkylphosphonate utilization operon protein PhnA
LCH18_03205	COG3422	double-strand break repair
LCH18_03230	COG0488	(ABC) transporter
LCH18_03245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LCH18_03255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LCH18_03265	COG0730	response to heat
LCH18_03275	COG1196	nuclear chromosome segregation
LCH18_03280	COG3115	cell septum assembly
LCH18_03285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LCH18_03290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCH18_03315	COG2193	ferroxidase activity
LCH18_03320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LCH18_03325	COG0596	Alpha beta hydrolase
LCH18_03325	COG2226	methyltransferase
LCH18_03325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LCH18_03340	COG4106	trans-aconitate 2-methyltransferase activity
LCH18_03370	COG4206	TonB-dependent receptor
LCH18_03410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LCH18_03415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LCH18_03425	COG0009	L-threonylcarbamoyladenylate synthase
LCH18_03430	COG3101	peptidyl-lysine hydroxylation
LCH18_03435	COG1399	metal-binding, possibly nucleic acid-binding protein
LCH18_03450	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_03460	COG1652	LysM domain
LCH18_03465	COG1802	Transcriptional regulator
LCH18_03485	COG3209	COG3209 Rhs family protein
LCH18_03495	COG3293	Transposase
LCH18_03550	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCH18_03570	COG0745	RESPONSE REGULATOR receiver
LCH18_03575	COG2205	protein histidine kinase activity
LCH18_03585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH18_03605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LCH18_03620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH18_03630	COG0713	ATP synthesis coupled electron transport
LCH18_03635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LCH18_03640	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCH18_03655	COG1278	Cold shock
LCH18_03660	COG1278	Cold shock
LCH18_03665	COG0583	DNA-binding transcription factor activity
LCH18_03690	COG0525	valine-tRNA ligase activity
LCH18_03700	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_03710	COG0393	Putative heavy-metal-binding
LCH18_03715	COG0393	Putative heavy-metal-binding
LCH18_03720	COG1538	Outer membrane efflux protein
LCH18_03730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH18_03735	COG0671	phosphoesterase, PA-phosphatase related
LCH18_03755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LCH18_03765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LCH18_03775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LCH18_03780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCH18_03780	COG1648	precorrin-2 dehydrogenase activity
LCH18_03785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LCH18_03805	COG0531	amino acid
LCH18_03820	COG0321	lipoyl(octanoyl) transferase activity
LCH18_03825	COG2921	Belongs to the UPF0250 family
LCH18_03845	COG1280	lysine exporter protein (LysE YggA)
LCH18_03850	COG0583	DNA-binding transcription factor activity
LCH18_03860	COG0586	Pfam SNARE associated Golgi protein
LCH18_03920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LCH18_03950	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LCH18_03965	COG0358	DNA primase activity
LCH18_03975	COG0564	pseudouridine synthase activity
LCH18_04000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCH18_04025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LCH18_04025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCH18_04040	COG0300	oxidoreductase activity
LCH18_04055	COG2009	succinate dehydrogenase
LCH18_04060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LCH18_04065	COG1053	succinate dehydrogenase
LCH18_04070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LCH18_04090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCH18_04100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LCH18_04110	COG0726	polysaccharide deacetylase
LCH18_04110	COG1649	PFAM Uncharacterised BCR, COG1649
LCH18_04115	COG1215	transferase activity, transferring glycosyl groups
LCH18_04125	COG1649	PFAM Uncharacterised BCR, COG1649
LCH18_04125	COG0726	polysaccharide deacetylase
LCH18_04135	COG2268	Band 7 protein
LCH18_04140	COG1585	Membrane protein implicated in regulation of membrane protease activity
LCH18_04155	COG2354	Protein conserved in bacteria
LCH18_04160	COG2321	neutral zinc metallopeptidase
LCH18_04200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LCH18_04205	COG0505	Belongs to the CarA family
LCH18_04230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LCH18_04235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LCH18_04275	COG2851	Citrate transporter
LCH18_04280	COG1253	flavin adenine dinucleotide binding
LCH18_04310	COG2239	Acts as a magnesium transporter
LCH18_04325	COG0501	Belongs to the peptidase M48B family
LCH18_04330	COG0741	lytic transglycosylase activity
LCH18_04335	COG0037	tRNA processing
LCH18_04345	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LCH18_04350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LCH18_04370	COG0697	spore germination
LCH18_04380	COG1309	transcriptional regulator
LCH18_04395	COG1741	Belongs to the pirin family
LCH18_04415	COG3739	integral membrane protein
LCH18_04430	COG3706	GGDEF domain
LCH18_04440	COG0302	gtp cyclohydrolase
LCH18_04455	COG0134	indole-3-glycerol-phosphate synthase activity
LCH18_04460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LCH18_04465	COG0512	Glutamine amidotransferase of anthranilate synthase
LCH18_04470	COG0174	glutamine synthetase
LCH18_04480	COG3161	chorismate lyase activity
LCH18_04485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LCH18_04525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCH18_04530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCH18_04535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LCH18_04540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCH18_04555	COG1115	amino acid carrier protein
LCH18_04560	COG1113	amino acid transport
LCH18_04570	COG0019	diaminopimelate decarboxylase activity
LCH18_04580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LCH18_04590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCH18_04595	COG1522	sequence-specific DNA binding
LCH18_04600	COG1280	lysine exporter protein (LysE YggA)
LCH18_04615	COG3293	Transposase
LCH18_04640	COG0842	Transport permease protein
LCH18_04645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH18_04680	COG0052	Belongs to the universal ribosomal protein uS2 family
LCH18_04715	COG2951	lytic endotransglycosylase activity
LCH18_04730	COG0842	Transport permease protein
LCH18_04735	COG1131	(ABC) transporter
LCH18_04790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LCH18_04815	COG3634	alkyl hydroperoxide reductase activity
LCH18_04820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCH18_04825	COG0826	peptidase U32
LCH18_04860	COG1720	tRNA m6t6A37 methyltransferase activity
LCH18_04870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LCH18_04885	COG0642	Histidine kinase
LCH18_04895	COG0494	nUDIX hydrolase
LCH18_04905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCH18_04910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LCH18_04915	COG3139	Protein of unknown function (DUF1315)
LCH18_04930	COG1301	dicarboxylic acid transport
LCH18_04935	COG1960	acyl-CoA dehydrogenase activity
LCH18_04940	COG0693	protein deglycase activity
LCH18_04950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LCH18_04955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LCH18_05000	COG0415	Belongs to the DNA photolyase family
LCH18_05010	COG2252	PERMEase
LCH18_05015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LCH18_05025	COG3038	cytochrome b561
LCH18_05040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LCH18_05050	COG0527	aspartate kinase activity
LCH18_05060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCH18_05075	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LCH18_05080	COG1522	sequence-specific DNA binding
LCH18_05095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LCH18_05110	COG0667	Aldo Keto reductase
LCH18_05120	COG1765	OsmC-like protein
LCH18_05145	COG0540	Belongs to the ATCase OTCase family
LCH18_05165	COG2031	fatty acid transporter
LCH18_05170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LCH18_05185	COG4770	biotin carboxylase activity
LCH18_05195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LCH18_05200	COG1960	acyl-CoA dehydrogenase activity
LCH18_05205	COG1309	transcriptional regulator
LCH18_05210	COG0318	PFAM AMP-dependent synthetase and ligase
LCH18_05240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LCH18_05250	COG0659	secondary active sulfate transmembrane transporter activity
LCH18_05255	COG0625	glutathione transferase activity
LCH18_05260	COG2249	NAD(P)H dehydrogenase (quinone) activity
LCH18_05285	COG2363	Small membrane protein
LCH18_05300	COG1278	Cold shock
LCH18_05305	COG0513	Belongs to the DEAD box helicase family
LCH18_05315	COG0778	Nitroreductase
LCH18_05340	COG0167	dihydroorotate dehydrogenase activity
LCH18_05370	COG4783	chaperone-mediated protein folding
LCH18_05375	COG1610	YqeY-like protein
LCH18_05405	COG0515	serine threonine protein kinase
LCH18_05405	COG2815	serine threonine protein kinase
LCH18_05445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCH18_05455	COG1643	Atp-dependent helicase
LCH18_05475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCH18_05475	COG1116	anion transmembrane transporter activity
LCH18_05485	COG2223	nitrite transmembrane transporter activity
LCH18_05490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCH18_05495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCH18_05500	COG0243	molybdopterin cofactor binding
LCH18_05510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LCH18_05545	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LCH18_05550	COG0406	alpha-ribazole phosphatase activity
LCH18_05560	COG0517	IMP dehydrogenase activity
LCH18_05560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LCH18_05565	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LCH18_05575	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LCH18_05580	COG1137	ATPase activity
LCH18_05600	COG4122	O-methyltransferase activity
LCH18_05610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LCH18_05650	COG2011	ABC-type metal ion transport system permease component
LCH18_05655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LCH18_05665	COG0151	Belongs to the GarS family
LCH18_05670	COG0138	bifunctional purine biosynthesis protein purh
LCH18_05675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LCH18_05705	COG0445	tRNA wobble uridine modification
LCH18_05720	COG2308	Evidence 4 Homologs of previously reported genes of
LCH18_05730	COG1305	Transglutaminase-like
LCH18_05750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LCH18_05755	COG0305	Participates in initiation and elongation during chromosome replication
LCH18_05770	COG0360	Binds together with S18 to 16S ribosomal RNA
LCH18_05790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LCH18_05795	COG1845	cytochrome c oxidase, subunit III
LCH18_05800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LCH18_05805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LCH18_05835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCH18_05850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LCH18_05855	COG2890	protein-(glutamine-N5) methyltransferase activity
LCH18_05860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCH18_05865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCH18_05895	COG1960	acyl-CoA dehydrogenase activity
LCH18_05900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCH18_05915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LCH18_05940	COG0729	surface antigen
LCH18_05990	COG4773	Receptor
LCH18_05995	COG0786	glutamate:sodium symporter activity
LCH18_06005	COG1113	amino acid transport
LCH18_06030	COG0024	Methionine aminopeptidase
LCH18_06035	COG0583	DNA-binding transcription factor activity
LCH18_06040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCH18_06055	COG3852	Histidine kinase
LCH18_06075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LCH18_06080	COG0575	Belongs to the CDS family
LCH18_06095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCH18_06115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCH18_06135	COG2137	regulation of response to DNA damage stimulus
LCH18_06140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LCH18_06145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LCH18_06150	COG1011	Hydrolase
LCH18_06195	COG0702	epimerase
LCH18_06200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LCH18_06220	COG1902	pentaerythritol trinitrate reductase activity
LCH18_06220	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCH18_06235	COG2814	Major facilitator Superfamily
LCH18_06245	COG0583	DNA-binding transcription factor activity
LCH18_06265	COG0148	phosphopyruvate hydratase activity
LCH18_06280	COG0772	Belongs to the SEDS family
LCH18_06290	COG2814	Major facilitator Superfamily
LCH18_06295	COG0579	oxidoreductase
LCH18_06305	COG1012	belongs to the aldehyde dehydrogenase family
LCH18_06310	COG1309	transcriptional regulator
LCH18_06315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LCH18_06330	COG4890	Cyd operon protein YbgT
LCH18_06335	COG1294	oxidase, subunit
LCH18_06350	COG1585	Membrane protein implicated in regulation of membrane protease activity
LCH18_06360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCH18_06380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCH18_06385	COG0569	domain protein
LCH18_06395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LCH18_06400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LCH18_06410	COG3706	GGDEF domain
LCH18_06425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LCH18_06430	COG0542	response to heat
LCH18_06460	COG0372	Belongs to the citrate synthase family
LCH18_06470	COG2819	hydrolase of the alpha beta superfamily
LCH18_06475	COG0318	PFAM AMP-dependent synthetase and ligase
LCH18_06495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LCH18_06495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LCH18_06500	COG1254	Belongs to the acylphosphatase family
LCH18_06505	COG1047	Peptidyl-prolyl cis-trans
LCH18_06510	COG1252	NADH dehydrogenase
LCH18_06515	COG1686	Belongs to the peptidase S11 family
LCH18_06525	COG2351	hydroxyisourate hydrolase activity
LCH18_06565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCH18_06570	COG1823	symporter activity
LCH18_06580	COG0612	Peptidase, M16
LCH18_06615	COG0352	thiamine-phosphate diphosphorylase activity
LCH18_06660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LCH18_06665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LCH18_06685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCH18_06685	COG0519	Catalyzes the synthesis of GMP from XMP
LCH18_06695	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_06705	COG4302	ethanolamine ammonia-lyase activity
LCH18_06710	COG4303	Ethanolamine ammonia lyase large subunit
LCH18_06715	COG0531	amino acid
LCH18_06735	COG1454	alcohol dehydrogenase
LCH18_06745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCH18_06750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCH18_06755	COG2814	Major facilitator Superfamily
LCH18_06760	COG2707	UPF0756 membrane protein
LCH18_06785	COG0802	atpase or kinase
LCH18_06790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LCH18_06800	COG1923	regulation of RNA biosynthetic process
LCH18_06805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH18_06815	COG3178	'Phosphotransferase
LCH18_06820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LCH18_06830	COG1192	Involved in chromosome partitioning
LCH18_06835	COG1475	DNA binding
LCH18_06840	COG0811	peptide transport
LCH18_06850	COG1132	(ABC) transporter
LCH18_06855	COG1663	tetraacyldisaccharide 4'-kinase activity
LCH18_06875	COG0084	hydrolase, TatD family'
LCH18_06910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LCH18_06920	COG0590	tRNA wobble adenosine to inosine editing
LCH18_06940	COG0776	regulation of translation
LCH18_06955	COG2431	L-lysine efflux transmembrane transporter activity
LCH18_06970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LCH18_06975	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LCH18_06995	COG1253	flavin adenine dinucleotide binding
LCH18_07020	COG0308	aminopeptidase N
LCH18_07030	COG0589	response to stress
LCH18_07045	COG2076	Multidrug Resistance protein
LCH18_07050	COG1309	transcriptional regulator
LCH18_07060	COG3135	benzoate transporter
LCH18_07070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LCH18_07075	COG0583	DNA-binding transcription factor activity
LCH18_07090	COG0183	Belongs to the thiolase family
LCH18_07095	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_07115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LCH18_07120	COG0824	Thioesterase
LCH18_07125	COG1454	alcohol dehydrogenase
LCH18_07130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LCH18_07150	COG0069	glutamate synthase activity
LCH18_07155	COG2197	response regulator
LCH18_07165	COG2850	peptidyl-arginine hydroxylation
LCH18_07170	COG0424	maF-like protein
LCH18_07180	COG0126	phosphoglycerate kinase activity
LCH18_07195	COG0697	spore germination
LCH18_07230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCH18_07235	COG3781	membrane
LCH18_07275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCH18_07280	COG1027	Aspartate ammonia-lyase
LCH18_07290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LCH18_07320	COG0316	Belongs to the HesB IscA family
LCH18_07325	COG0822	iron-sulfur transferase activity
LCH18_07335	COG1959	2 iron, 2 sulfur cluster binding
LCH18_07350	COG0776	regulation of translation
LCH18_07355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCH18_07385	COG0537	adenosine 5'-monophosphoramidase activity
LCH18_07430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LCH18_07435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LCH18_07450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LCH18_07460	COG0133	tryptophan synthase activity
LCH18_07465	COG0517	IMP dehydrogenase activity
LCH18_07465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LCH18_07490	COG0612	Peptidase, M16
LCH18_07495	COG0552	protein localization to endoplasmic reticulum
LCH18_07545	COG1960	acyl-CoA dehydrogenase activity
LCH18_07550	COG1960	acyl-CoA dehydrogenase activity
LCH18_07595	COG2199	diguanylate cyclase activity
LCH18_07605	COG2814	Major facilitator Superfamily
LCH18_07610	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_07635	COG0864	Transcriptional regulator
LCH18_07705	COG0596	Alpha beta hydrolase
LCH18_07860	COG0783	Belongs to the Dps family
LCH18_07865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCH18_07880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCH18_07885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH18_07910	COG4628	conserved protein (DUF2132)
LCH18_07915	COG0583	DNA-binding transcription factor activity
LCH18_08010	COG2814	Major facilitator Superfamily
LCH18_08015	COG0583	DNA-binding transcription factor activity
LCH18_08020	COG4948	Mandelate Racemase Muconate Lactonizing
LCH18_08025	COG4829	muconolactone delta-isomerase
LCH18_08035	COG4638	Rieske (2fe-2S)
LCH18_08040	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LCH18_08045	COG0633	Ferredoxin
LCH18_08045	COG0543	2 iron, 2 sulfur cluster binding
LCH18_08050	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_08055	COG3135	benzoate transporter
LCH18_08060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LCH18_08065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LCH18_08070	COG0183	Belongs to the thiolase family
LCH18_08075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LCH18_08085	COG0511	ligase activity, forming carbon-carbon bonds
LCH18_08100	COG0439	Biotin carboxylase
LCH18_08115	COG0583	DNA-binding transcription factor activity
LCH18_08120	COG0183	Belongs to the thiolase family
LCH18_08130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LCH18_08140	COG2233	PERMEase
LCH18_08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCH18_08150	COG0251	oxidation-reduction process
LCH18_08155	COG1335	isochorismatase
LCH18_08160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCH18_08165	COG0596	Alpha beta hydrolase
LCH18_08170	COG0640	Transcriptional regulator
LCH18_08190	COG3122	Protein conserved in bacteria
LCH18_08195	COG0668	transmembrane transport
LCH18_08205	COG1132	(ABC) transporter
LCH18_08220	COG2814	Major facilitator Superfamily
LCH18_08230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCH18_08235	COG3300	MHYT domain
LCH18_08235	COG5001	Diguanylate cyclase
LCH18_08250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LCH18_08255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCH18_08355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LCH18_08550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCH18_08610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCH18_08615	COG0583	DNA-binding transcription factor activity
LCH18_08620	COG1380	Effector of murein hydrolase LrgA
LCH18_08625	COG1346	cytolysis
LCH18_08640	COG2223	nitrite transmembrane transporter activity
LCH18_08670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LCH18_08675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCH18_08680	COG2207	Transcriptional regulator
LCH18_08685	COG1944	ATP diphosphatase activity
LCH18_08690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LCH18_08695	COG4773	Receptor
LCH18_08720	COG0730	response to heat
LCH18_08725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LCH18_08785	COG0204	Acyl-transferase
LCH18_08820	COG1464	Belongs to the NlpA lipoprotein family
LCH18_08825	COG1464	Belongs to the NlpA lipoprotein family
LCH18_08830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LCH18_08835	COG2011	ABC-type metal ion transport system permease component
LCH18_08840	COG0012	GTP binding
LCH18_08870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LCH18_08885	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LCH18_08910	COG0386	Belongs to the glutathione peroxidase family
LCH18_08915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCH18_08920	COG0436	Aminotransferase
LCH18_08940	COG3634	alkyl hydroperoxide reductase activity
LCH18_08965	COG2070	2-Nitropropane dioxygenase
LCH18_09005	COG1278	Cold shock
LCH18_09030	COG0604	alcohol dehydrogenase
LCH18_09035	COG1733	regulation of RNA biosynthetic process
LCH18_09110	COG1309	transcriptional regulator
LCH18_09135	COG0842	Transport permease protein
LCH18_09140	COG0842	Transport permease protein
LCH18_09145	COG1131	(ABC) transporter
LCH18_09180	COG1538	Outer membrane efflux protein
LCH18_09190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCH18_09195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LCH18_09230	COG1538	Outer membrane efflux protein
LCH18_09235	COG0457	Tetratricopeptide repeat
LCH18_09235	COG0463	Glycosyl transferase, family 2
LCH18_09265	COG1126	abc transporter atp-binding protein
LCH18_09270	COG0765	amino acid transport
LCH18_09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCH18_09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCH18_09295	COG1473	amidohydrolase
LCH18_09300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCH18_09310	COG0625	glutathione transferase activity
LCH18_09370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LCH18_09375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LCH18_09390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCH18_09395	COG1414	Transcriptional regulator
LCH18_09405	COG4771	TonB-dependent receptor
LCH18_09425	COG2816	NAD+ diphosphatase activity
LCH18_09430	COG3046	protein related to deoxyribodipyrimidine photolyase
LCH18_09445	COG2351	hydroxyisourate hydrolase activity
LCH18_09465	COG2199	diguanylate cyclase activity
LCH18_09465	COG2203	Gaf domain
LCH18_09485	COG1595	DNA-templated transcription, initiation
LCH18_09495	COG3220	belongs to the UPF0276 family
LCH18_09560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LCH18_09580	COG1335	isochorismatase
LCH18_09585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LCH18_09670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCH18_09780	COG0740	serine-type endopeptidase activity
LCH18_09785	COG4695	Portal protein
LCH18_09790	COG1802	Transcriptional regulator
LCH18_09790	COG4626	Terminase
LCH18_09855	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
LCH18_09975	COG0714	Associated with various cellular activities
LCH18_09980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LCH18_09985	COG2879	small protein
LCH18_09990	COG1966	Carbon starvation protein
LCH18_09995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LCH18_10015	COG0254	rRNA binding
LCH18_10035	COG1067	ATP-dependent peptidase activity
LCH18_10040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LCH18_10045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LCH18_10050	COG0616	signal peptide processing
LCH18_10055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LCH18_10065	COG0573	inorganic phosphate transmembrane transporter activity
LCH18_10070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LCH18_10075	COG0076	glutamate decarboxylase activity
LCH18_10080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LCH18_10095	COG0671	phosphoesterase, PA-phosphatase related
LCH18_10100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LCH18_10110	COG1733	regulation of RNA biosynthetic process
LCH18_10145	COG0556	nucleotide-excision repair
LCH18_10160	COG2199	diguanylate cyclase activity
LCH18_10170	COG0436	Aminotransferase
LCH18_10210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LCH18_10215	COG1381	Involved in DNA repair and RecF pathway recombination
LCH18_10225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LCH18_10230	COG0571	ribonuclease III activity
LCH18_10240	COG0681	Belongs to the peptidase S26 family
LCH18_10275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LCH18_10290	COG3772	lysozyme
LCH18_10575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCH18_10595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LCH18_10605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LCH18_10620	COG4208	sulfate ABC transporter
LCH18_10625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LCH18_10630	COG0583	DNA-binding transcription factor activity
LCH18_10650	COG0602	queuosine metabolic process
LCH18_10655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LCH18_10670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LCH18_10680	COG0583	DNA-binding transcription factor activity
LCH18_10685	COG2353	YceI-like domain
LCH18_10690	COG1051	belongs to the nudix hydrolase family
LCH18_10690	COG1056	cytidyltransferase-related domain
LCH18_10695	COG1024	Enoyl-CoA hydratase
LCH18_10700	COG0778	Nitroreductase
LCH18_10705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LCH18_10705	COG3323	Protein of unknown function (DUF1653)
LCH18_10715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LCH18_10715	COG0047	phosphoribosylformylglycinamidine synthase activity
LCH18_10730	COG2255	four-way junction helicase activity
LCH18_10745	COG0824	Thioesterase
LCH18_10765	COG0823	Involved in the tonB-independent uptake of proteins
LCH18_10785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCH18_10815	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LCH18_10820	COG0628	permease
LCH18_10825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LCH18_10830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LCH18_10850	COG2333	competence protein COMEC
LCH18_10850	COG0658	competence protein
LCH18_10855	COG1136	(ABC) transporter
LCH18_10860	COG4591	ABC-type transport system involved in lipoprotein release permease component
LCH18_10875	COG1671	Belongs to the UPF0178 family
LCH18_10890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCH18_10895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LCH18_10900	COG1960	acyl-CoA dehydrogenase activity
LCH18_10940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LCH18_10945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LCH18_10950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LCH18_10955	COG5001	Diguanylate cyclase
LCH18_10955	COG1716	ATPase activity
LCH18_10960	COG0280	phosphate acetyltransferase
LCH18_10960	COG0281	malic enzyme
LCH18_10970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LCH18_10990	COG0446	pyridine nucleotide-disulphide oxidoreductase
LCH18_10990	COG1902	pentaerythritol trinitrate reductase activity
LCH18_10995	COG0277	FAD linked oxidase domain protein
LCH18_11005	COG2186	Transcriptional regulator
LCH18_11020	COG3706	GGDEF domain
LCH18_11020	COG4251	negative regulation of phosphorylation
LCH18_11020	COG5001	Diguanylate cyclase
LCH18_11020	COG2203	Gaf domain
LCH18_11025	COG0418	dihydroorotase activity
LCH18_11030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCH18_11045	COG0833	amino acid
LCH18_11055	COG0833	amino acid
LCH18_11080	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
LCH18_11095	COG4172	Belongs to the ABC transporter superfamily
LCH18_11100	COG4239	(ABC) transporter, permease
LCH18_11105	COG4174	ABC transporter (Permease)
LCH18_11110	COG4166	transmembrane transport
LCH18_11115	COG1388	LysM domain
LCH18_11115	COG0741	lytic transglycosylase activity
LCH18_11120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCH18_11130	COG2816	NAD+ diphosphatase activity
LCH18_11135	COG0657	acetylesterase activity
LCH18_11155	COG0583	DNA-binding transcription factor activity
LCH18_11160	COG1388	LysM domain
LCH18_11160	COG4942	peptidase
LCH18_11175	COG0753	catalase activity
LCH18_11190	COG0789	Transcriptional regulator
LCH18_11210	COG1686	Belongs to the peptidase S11 family
LCH18_11215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LCH18_11220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LCH18_11225	COG2267	carboxylic ester hydrolase activity
LCH18_11230	COG0671	phosphoesterase, PA-phosphatase related
LCH18_11230	COG2453	phosphatase
LCH18_11245	COG4589	Belongs to the CDS family
LCH18_11260	COG2915	High frequency lysogenization protein hflD homolog
LCH18_11280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCH18_11285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCH18_11305	COG0006	proline dipeptidase activity
LCH18_11335	COG3177	Filamentation induced by cAMP protein fic
LCH18_11395	COG1160	GTP binding
LCH18_11430	COG4770	biotin carboxylase activity
LCH18_11455	COG0583	DNA-binding transcription factor activity
LCH18_11460	COG2217	Heavy metal translocating P-type atpase
LCH18_11470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LCH18_11485	COG2234	aminopeptidase activity
LCH18_11495	COG3384	dioxygenase
LCH18_11505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LCH18_11510	COG2878	Part of a membrane complex involved in electron transport
LCH18_11515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LCH18_11540	COG0768	penicillin binding
LCH18_11545	COG0742	ribosomal rna small subunit methyltransferase
LCH18_11575	COG0641	radical SAM
LCH18_11630	COG1597	lipid kinase activity
LCH18_11650	COG0477	Major facilitator Superfamily
LCH18_11690	COG0604	alcohol dehydrogenase
LCH18_11690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LCH18_11690	COG3321	synthase
LCH18_11690	COG4221	oxidoreductase activity
LCH18_11705	COG1695	Transcriptional regulator
LCH18_11745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LCH18_11750	COG1773	rubredoxin
LCH18_11755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCH18_11765	COG0583	DNA-binding transcription factor activity
LCH18_11785	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LCH18_11790	COG4181	ATPase activity
LCH18_11815	COG4771	TonB-dependent receptor
LCH18_11840	COG0306	phosphate transporter
LCH18_11855	COG2852	Protein conserved in bacteria
LCH18_11870	COG2223	nitrite transmembrane transporter activity
LCH18_11875	COG2207	Transcriptional regulator
LCH18_11880	COG0242	peptide deformylase activity
LCH18_11885	COG0477	Major facilitator Superfamily
LCH18_11930	COG2203	Gaf domain
LCH18_11930	COG2199	diguanylate cyclase activity
LCH18_11940	COG4681	YaeQ
LCH18_11945	COG0523	cobalamin synthesis protein
LCH18_11955	COG1607	acyl-coa hydrolase
LCH18_11960	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCH18_11970	COG1115	amino acid carrier protein
LCH18_11975	COG0786	glutamate:sodium symporter activity
LCH18_11990	COG2814	Major facilitator Superfamily
LCH18_11995	COG1289	transmembrane transporter activity
LCH18_12005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LCH18_12075	COG2832	Protein of unknown function (DUF454)
LCH18_12090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LCH18_12100	COG0643	Histidine kinase
LCH18_12100	COG0784	Response regulator, receiver
LCH18_12100	COG2198	Histidine kinase
LCH18_12105	COG0840	transmembrane signaling receptor activity
LCH18_12175	COG2358	TRAP transporter, solute receptor (TAXI family
LCH18_12190	COG0489	protein tyrosine kinase activity
LCH18_12210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCH18_12210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCH18_12245	COG4716	Myosin-crossreactive antigen
LCH18_12275	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LCH18_12280	COG2081	HI0933 family
LCH18_12295	COG0668	transmembrane transport
LCH18_12315	COG0765	amino acid transport
LCH18_12320	COG0765	amino acid transport
LCH18_12325	COG1126	abc transporter atp-binding protein
LCH18_12335	COG0004	ammonium transporteR
LCH18_12350	COG0642	Histidine kinase
LCH18_12355	COG0745	RESPONSE REGULATOR receiver
LCH18_12380	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCH18_12395	COG0142	geranyltranstransferase activity
LCH18_12400	COG2828	Protein conserved in bacteria
LCH18_12405	COG1113	amino acid transport
LCH18_12425	COG1113	amino acid transport
LCH18_12445	COG0625	glutathione transferase activity
LCH18_12455	COG2072	flavoprotein involved in K transport
LCH18_12460	COG0431	NADPH-dependent FMN reductase
LCH18_12465	COG0798	PFAM Bile acid sodium symporter
LCH18_12475	COG0640	Transcriptional regulator
LCH18_12530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LCH18_12550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LCH18_12555	COG1792	Involved in formation and maintenance of cell shape
LCH18_12560	COG1077	Cell shape determining protein MreB Mrl
LCH18_12565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LCH18_12575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LCH18_12625	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LCH18_12635	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_12640	COG2610	gluconate transmembrane transporter activity
LCH18_12645	COG0583	DNA-binding transcription factor activity
LCH18_12655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LCH18_12665	COG4772	TonB-dependent receptor
LCH18_12670	COG4993	Dehydrogenase
LCH18_12675	COG3659	wide pore channel activity
LCH18_12680	COG3420	alginic acid biosynthetic process
LCH18_12685	COG0710	3-dehydroquinate dehydratase activity
LCH18_12690	COG3485	protocatechuate 3,4-dioxygenase
LCH18_12695	COG3485	protocatechuate 3,4-dioxygenase
LCH18_12700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCH18_12705	COG2271	Major facilitator Superfamily
LCH18_12710	COG0596	Alpha beta hydrolase
LCH18_12715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LCH18_12720	COG0183	Belongs to the thiolase family
LCH18_12725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LCH18_12730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LCH18_12735	COG1414	Transcriptional regulator
LCH18_12760	COG1113	amino acid transport
LCH18_12770	COG3724	N-succinylarginine dihydrolase activity
LCH18_12775	COG1012	belongs to the aldehyde dehydrogenase family
LCH18_12790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LCH18_12795	COG1522	sequence-specific DNA binding
LCH18_12815	COG1012	belongs to the aldehyde dehydrogenase family
LCH18_12820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LCH18_12830	COG1113	amino acid transport
LCH18_12850	COG1271	oxidase subunit
LCH18_12855	COG1294	oxidase, subunit
LCH18_12865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH18_12880	COG1522	sequence-specific DNA binding
LCH18_12890	COG0583	DNA-binding transcription factor activity
LCH18_12895	COG2814	Major facilitator Superfamily
LCH18_12905	COG0737	Belongs to the 5'-nucleotidase family
LCH18_12920	COG3188	usher protein
LCH18_12980	COG1802	Transcriptional regulator
LCH18_12990	COG2186	Transcriptional regulator
LCH18_13000	COG1012	belongs to the aldehyde dehydrogenase family
LCH18_13010	COG2271	Major facilitator Superfamily
LCH18_13015	COG2721	sulfolactate sulfo-lyase activity
LCH18_13020	COG0697	spore germination
LCH18_13025	COG0475	glutathione-regulated potassium exporter activity
LCH18_13025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LCH18_13030	COG0697	spore germination
LCH18_13035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH18_13040	COG0235	Class ii aldolase
LCH18_13045	COG2169	Transcriptional regulator
LCH18_13080	COG4149	molybdate abc transporter
LCH18_13085	COG0725	ABC transporter, periplasmic molybdate-binding protein
LCH18_13095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LCH18_13100	COG0243	molybdopterin cofactor binding
LCH18_13105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LCH18_13110	COG0315	cyclic pyranopterin monophosphate synthase activity
LCH18_13110	COG0521	Mo-molybdopterin cofactor biosynthetic process
LCH18_13115	COG0303	'Molybdopterin
LCH18_13130	COG0314	molybdopterin synthase activity
LCH18_13135	COG2365	Tyrosine phosphatase family
LCH18_13235	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LCH18_13250	COG0604	alcohol dehydrogenase
LCH18_13250	COG3321	synthase
LCH18_13255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LCH18_13260	COG0583	DNA-binding transcription factor activity
LCH18_13265	COG4221	oxidoreductase activity
LCH18_13285	COG3177	Filamentation induced by cAMP protein fic
LCH18_13290	COG3293	Transposase
LCH18_13295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCH18_13330	COG0642	Histidine kinase
LCH18_13345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LCH18_13370	COG2816	NAD+ diphosphatase activity
LCH18_13375	COG3046	protein related to deoxyribodipyrimidine photolyase
LCH18_13495	COG1785	Belongs to the alkaline phosphatase family
LCH18_13500	COG1785	Belongs to the alkaline phosphatase family
LCH18_13525	COG0582	viral genome integration into host DNA
LCH18_13535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LCH18_13540	COG2814	Major facilitator Superfamily
LCH18_13545	COG1566	PFAM secretion protein HlyD family protein
LCH18_13550	COG2050	protein possibly involved in aromatic compounds catabolism
LCH18_13565	COG1090	epimerase
LCH18_13575	COG2203	Gaf domain
LCH18_13575	COG3706	GGDEF domain
LCH18_13575	COG4251	negative regulation of phosphorylation
LCH18_13575	COG5001	Diguanylate cyclase
LCH18_13580	COG0420	3'-5' exonuclease activity
LCH18_13610	COG0735	belongs to the Fur family
LCH18_13615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LCH18_13620	COG2914	Belongs to the UPF0125 (RnfH) family
LCH18_13635	COG0121	glutamine amidotransferase
LCH18_13650	COG0756	dUTP diphosphatase activity
LCH18_13655	COG0210	DNA helicase
LCH18_13660	COG2885	chlorophyll binding
LCH18_13665	COG0204	Acyl-transferase
LCH18_13675	COG0850	regulation of cytokinetic process
LCH18_13680	COG2894	cell division
LCH18_13685	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LCH18_13700	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LCH18_13700	COG1674	ftsk spoiiie
LCH18_13705	COG0492	ferredoxin-NADP+ reductase activity
LCH18_13710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LCH18_13720	COG0456	acetyltransferase
LCH18_13745	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LCH18_13760	COG1981	membrane
LCH18_13770	COG1113	amino acid transport
LCH18_13775	COG0251	oxidation-reduction process
LCH18_13815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LCH18_13840	COG2132	Multicopper oxidase
LCH18_13850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LCH18_13885	COG1968	undecaprenyl-diphosphatase activity
LCH18_13890	COG1214	PFAM Peptidase M22, glycoprotease
LCH18_13895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LCH18_13900	COG0494	nUDIX hydrolase
LCH18_13955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LCH18_13965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LCH18_14005	COG2814	Major facilitator Superfamily
LCH18_14035	COG2853	Lipoprotein
LCH18_14040	COG2208	phosphoserine phosphatase activity
LCH18_14050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCH18_14055	COG1764	response to oxidative stress
LCH18_14085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCH18_14085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCH18_14100	COG0037	tRNA processing
LCH18_14110	COG0248	Ppx GppA phosphatase
LCH18_14135	COG0072	phenylalanine-tRNA ligase activity
LCH18_14185	COG1238	metal cluster binding
LCH18_14200	COG0625	glutathione transferase activity
LCH18_14220	COG0318	PFAM AMP-dependent synthetase and ligase
LCH18_14225	COG3028	Belongs to the UPF0307 family
LCH18_14235	COG1660	Displays ATPase and GTPase activities
LCH18_14240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LCH18_14250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LCH18_14255	COG0617	tRNA 3'-terminal CCA addition
LCH18_14260	COG1555	photosystem II stabilization
LCH18_14265	COG3956	TIGRFAM MazG family protein
LCH18_14275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCH18_14290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LCH18_14295	COG5002	protein histidine kinase activity
LCH18_14295	COG0784	Response regulator, receiver
LCH18_14295	COG2205	protein histidine kinase activity
LCH18_14300	COG1024	Enoyl-CoA hydratase
LCH18_14305	COG2084	Dehydrogenase
LCH18_14310	COG3622	Belongs to the hyi family
LCH18_14350	COG2814	Major facilitator Superfamily
LCH18_14380	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LCH18_14390	COG0732	type I restriction modification DNA specificity domain
LCH18_14400	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LCH18_14480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCH18_14500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LCH18_14510	COG0084	hydrolase, TatD family'
LCH18_14525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LCH18_14535	COG0793	Belongs to the peptidase S41A family
LCH18_14560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LCH18_14565	COG0280	phosphate acetyltransferase
LCH18_14565	COG0857	belongs to the CobB CobQ family
LCH18_14575	COG2318	DinB family
LCH18_14585	COG1917	Cupin 2, conserved barrel domain protein
LCH18_14585	COG2207	Transcriptional regulator
LCH18_14595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LCH18_14595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LCH18_14615	COG0740	serine-type endopeptidase activity
LCH18_14625	COG4771	TonB-dependent receptor
LCH18_14630	COG4774	siderophore transport
LCH18_14635	COG3128	pkhd-type hydroxylase
LCH18_14645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCH18_14655	COG2813	Specifically methylates the guanine in position
LCH18_14655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LCH18_14765	COG0788	formyltetrahydrofolate deformylase activity
LCH18_14790	COG4651	solute:proton antiporter activity
LCH18_14790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LCH18_14815	COG0210	DNA helicase
LCH18_14820	COG1929	Belongs to the glycerate kinase type-1 family
LCH18_14865	COG2900	Belongs to the SlyX family
LCH18_14870	COG0488	(ABC) transporter
LCH18_14880	COG1560	Kdo2-lipid A biosynthetic process
LCH18_14935	COG0473	3-isopropylmalate dehydrogenase activity
LCH18_14950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LCH18_14960	COG0583	DNA-binding transcription factor activity
LCH18_15000	COG1280	lysine exporter protein (LysE YggA)
LCH18_15015	COG1960	acyl-CoA dehydrogenase activity
LCH18_15040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LCH18_15055	COG0583	DNA-binding transcription factor activity
LCH18_15070	COG0564	pseudouridine synthase activity
LCH18_15075	COG1530	ribonuclease E activity
LCH18_15080	COG0318	PFAM AMP-dependent synthetase and ligase
LCH18_15105	COG1983	PspC domain protein
LCH18_15125	COG0751	glycine-tRNA ligase activity
LCH18_15150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCH18_15165	COG2226	methyltransferase
LCH18_15180	COG0493	'glutamate synthase
LCH18_15180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LCH18_15190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LCH18_15200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCH18_15205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LCH18_15215	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LCH18_15225	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LCH18_15225	COG0644	oxidoreductase
LCH18_15235	COG0425	Belongs to the sulfur carrier protein TusA family
LCH18_15240	COG4535	Mg2 and Co2 transporter CorC
LCH18_15245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LCH18_15250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCH18_15270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LCH18_15280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LCH18_15300	COG2841	Protein conserved in bacteria
LCH18_15305	COG0598	Magnesium transport protein CorA
LCH18_15310	COG1185	polyribonucleotide nucleotidyltransferase activity
LCH18_15320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LCH18_15325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCH18_15330	COG1074	ATP-dependent DNA helicase activity
LCH18_15335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LCH18_15365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LCH18_15385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LCH18_15395	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LCH18_15400	COG2111	Na H antiporter
LCH18_15400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LCH18_15405	COG1006	Multisubunit Na H antiporter MnhC subunit
LCH18_15410	COG0651	ATP synthesis coupled electron transport
LCH18_15415	COG1863	multisubunit Na H antiporter MnhE subunit
LCH18_15420	COG2212	antiporter activity
LCH18_15425	COG1320	monovalent cation:proton antiporter activity
LCH18_15430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LCH18_15440	COG0195	Participates in both transcription termination and antitermination
LCH18_15500	COG0237	dephospho-CoA kinase activity
LCH18_15510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCH18_15520	COG0497	DNA recombination
LCH18_15525	COG1678	Uncharacterized ACR, COG1678
LCH18_15530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LCH18_15545	COG1289	transmembrane transporter activity
LCH18_15560	COG1132	(ABC) transporter
LCH18_15565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LCH18_15640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LCH18_15670	COG0326	Molecular chaperone. Has ATPase activity
LCH18_15680	COG3047	cAMP biosynthetic process
LCH18_15685	COG2056	Na+-H+ antiporter family
LCH18_15715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LCH18_15720	COG0085	RNA polymerase activity
LCH18_15725	COG0222	ribosome binding
LCH18_15730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LCH18_15735	COG0081	regulation of translation
LCH18_15740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LCH18_15790	COG0546	phosphoglycolate phosphatase activity
LCH18_15820	COG0824	Thioesterase
LCH18_15840	COG0181	hydroxymethylbilane synthase activity
LCH18_15850	COG3275	phosphorelay sensor kinase activity
LCH18_15870	COG1538	Outer membrane efflux protein
LCH18_15880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LCH18_15890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LCH18_15895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LCH18_15900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCH18_15905	COG0772	Belongs to the SEDS family
LCH18_15910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LCH18_15930	COG4974	Belongs to the 'phage' integrase family
LCH18_15935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LCH18_15945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LCH18_15950	COG1686	Belongs to the peptidase S11 family
LCH18_15955	COG2197	response regulator
LCH18_15970	COG0793	Belongs to the peptidase S41A family
LCH18_15975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LCH18_15980	COG0795	lipopolysaccharide-transporting ATPase activity
LCH18_15985	COG0795	lipopolysaccharide-transporting ATPase activity
LCH18_16005	COG0586	Pfam SNARE associated Golgi protein
LCH18_16020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCH18_16020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCH18_16030	COG0004	ammonium transporteR
LCH18_16035	COG0347	Belongs to the P(II) protein family
LCH18_16045	COG0606	chelatase, subunit chli
LCH18_16065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LCH18_16080	COG0318	PFAM AMP-dependent synthetase and ligase
LCH18_16090	COG0477	Major facilitator Superfamily
LCH18_16095	COG2860	membrane
LCH18_16100	COG3012	SEC-C Motif Domain Protein
LCH18_16105	COG1253	flavin adenine dinucleotide binding
LCH18_16125	COG2814	Major facilitator Superfamily
LCH18_16135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LCH18_16210	COG0758	DNA mediated transformation
LCH18_16220	COG0697	spore germination
LCH18_16230	COG0386	Belongs to the glutathione peroxidase family
LCH18_16265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LCH18_16315	COG1121	(ABC) transporter
LCH18_16320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LCH18_16325	COG1683	Conserved Protein
LCH18_16335	COG2837	iron assimilation
LCH18_16360	COG0281	malic enzyme
LCH18_16415	COG0519	Catalyzes the synthesis of GMP from XMP
LCH18_16415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCH18_16425	COG2259	Doxx family
LCH18_16430	COG0586	Pfam SNARE associated Golgi protein
LCH18_16445	COG1192	Involved in chromosome partitioning
LCH18_16455	COG0271	Belongs to the BolA IbaG family
LCH18_16495	COG3756	Protein conserved in bacteria
LCH18_16570	COG4566	intracellular signal transduction
LCH18_16575	COG2205	protein histidine kinase activity
LCH18_16575	COG0745	RESPONSE REGULATOR receiver
LCH18_16575	COG4191	Histidine kinase
LCH18_16580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCH18_16585	COG4569	acetaldehyde dehydrogenase (acetylating) activity
LCH18_16590	COG3971	2-oxopent-4-enoate hydratase activity
LCH18_16595	COG0346	lactoylglutathione lyase activity
LCH18_16625	COG2267	carboxylic ester hydrolase activity
LCH18_16640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LCH18_16645	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LCH18_16645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCH18_16645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCH18_16650	COG1105	Belongs to the carbohydrate kinase PfkB family
LCH18_16655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCH18_16655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LCH18_16675	COG0583	DNA-binding transcription factor activity
LCH18_16685	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LCH18_16700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LCH18_16710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LCH18_16715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LCH18_16725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LCH18_16740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LCH18_16750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LCH18_16765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LCH18_16785	COG1215	transferase activity, transferring glycosyl groups
LCH18_16790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LCH18_16795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LCH18_16810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LCH18_16820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LCH18_16830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LCH18_16835	COG0438	transferase activity, transferring glycosyl groups
LCH18_16840	COG0438	transferase activity, transferring glycosyl groups
LCH18_16845	COG0438	transferase activity, transferring glycosyl groups
LCH18_16870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LCH18_16875	COG1596	polysaccharide export
LCH18_16900	COG0728	peptidoglycan biosynthetic process
LCH18_16905	COG3023	N-Acetylmuramoyl-L-alanine amidase
LCH18_16915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LCH18_16925	COG3307	-O-antigen
LCH18_16930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LCH18_16935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCH18_16940	COG0546	phosphoglycolate phosphatase activity
LCH18_16945	COG1028	Short-chain dehydrogenase reductase Sdr
LCH18_16970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LCH18_16970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LCH18_16975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCH18_16980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCH18_16985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCH18_16990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCH18_16995	COG1116	anion transmembrane transporter activity
LCH18_17000	COG1309	transcriptional regulator
LCH18_17015	COG0196	riboflavin kinase activity
LCH18_17020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LCH18_17025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LCH18_17030	COG1047	Peptidyl-prolyl cis-trans
LCH18_17050	COG2133	pyrroloquinoline quinone binding
LCH18_17080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LCH18_17085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LCH18_17090	COG2951	lytic endotransglycosylase activity
LCH18_17095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LCH18_17110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCH18_17130	COG0861	Integral membrane protein TerC family
LCH18_17140	COG0754	glutathionylspermidine amidase activity
LCH18_17150	COG0402	S-adenosylhomocysteine deaminase activity
LCH18_17170	COG1230	cation diffusion facilitator family transporter
LCH18_17185	COG0583	DNA-binding transcription factor activity
LCH18_17200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LCH18_17205	COG0281	malic enzyme
LCH18_17215	COG0706	membrane insertase activity
LCH18_17220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LCH18_17260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LCH18_17280	COG2323	membrane
LCH18_17325	COG2223	nitrite transmembrane transporter activity
LCH18_17330	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LCH18_17335	COG1877	trehalose-phosphatase activity
LCH18_17350	COG1570	exodeoxyribonuclease VII activity
LCH18_17415	COG0210	DNA helicase
LCH18_17430	COG4115	mRNA cleavage
LCH18_17465	COG2026	Addiction module toxin, RelE StbE family
LCH18_17480	COG0582	viral genome integration into host DNA
LCH18_17495	COG4680	protein conserved in bacteria
LCH18_17520	COG3121	Chaperone
LCH18_17525	COG3188	usher protein
LCH18_17555	COG3706	GGDEF domain
LCH18_17575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCH18_17585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCH18_17590	COG1113	amino acid transport
LCH18_17595	COG0697	spore germination
LCH18_17655	COG1475	DNA binding
LCH18_17660	COG1192	Involved in chromosome partitioning
LCH18_17695	COG3657	addiction module killer protein
LCH18_17700	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCH18_17705	COG1335	isochorismatase
LCH18_17710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold