locus-tag	class	description
H0S57_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S57_00010	COG0592	DNA-directed DNA polymerase activity
H0S57_00020	COG0187	DNA topoisomerase II activity
H0S57_00035	COG0488	(ABC) transporter
H0S57_00100	COG0657	acetylesterase activity
H0S57_00110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S57_00140	COG2133	pyrroloquinoline quinone binding
H0S57_00155	COG1047	Peptidyl-prolyl cis-trans
H0S57_00160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0S57_00165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S57_00170	COG0196	riboflavin kinase activity
H0S57_00185	COG1309	transcriptional regulator
H0S57_00190	COG1116	anion transmembrane transporter activity
H0S57_00195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S57_00200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S57_00205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_00210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_00215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S57_00215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H0S57_00240	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_00245	COG0546	phosphoglycolate phosphatase activity
H0S57_00250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0S57_00255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S57_00260	COG3307	-O-antigen
H0S57_00270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S57_00280	COG3023	N-Acetylmuramoyl-L-alanine amidase
H0S57_00285	COG0728	peptidoglycan biosynthetic process
H0S57_00315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H0S57_00340	COG0438	transferase activity, transferring glycosyl groups
H0S57_00345	COG0438	transferase activity, transferring glycosyl groups
H0S57_00350	COG0438	transferase activity, transferring glycosyl groups
H0S57_00355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0S57_00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S57_00370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0S57_00385	COG1091	dTDP-4-dehydrorhamnose reductase activity
H0S57_00410	COG1442	glycosyl transferase family 8
H0S57_00410	COG1216	Glycosyl transferase, family 2
H0S57_00415	COG0463	Glycosyl transferase, family 2
H0S57_00420	COG0297	glycogen (starch) synthase activity
H0S57_00420	COG0438	transferase activity, transferring glycosyl groups
H0S57_00430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S57_00435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H0S57_00450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S57_00460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S57_00475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S57_00485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0S57_00490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0S57_00500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0S57_00515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0S57_00520	COG0583	DNA-binding transcription factor activity
H0S57_00540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S57_00565	COG2986	histidine ammonia-lyase
H0S57_00605	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_00610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0S57_00680	COG1538	Outer membrane efflux protein
H0S57_00715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0S57_00735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_00765	COG2205	protein histidine kinase activity
H0S57_00765	COG0784	Response regulator, receiver
H0S57_00780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_00865	COG0271	Belongs to the BolA IbaG family
H0S57_00875	COG1192	Involved in chromosome partitioning
H0S57_00890	COG0586	Pfam SNARE associated Golgi protein
H0S57_00905	COG0519	Catalyzes the synthesis of GMP from XMP
H0S57_00905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S57_00910	COG1715	Restriction endonuclease
H0S57_00955	COG0281	malic enzyme
H0S57_00980	COG2837	iron assimilation
H0S57_00990	COG1683	Conserved Protein
H0S57_00995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0S57_01000	COG1121	(ABC) transporter
H0S57_01050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0S57_01095	COG0386	Belongs to the glutathione peroxidase family
H0S57_01105	COG0697	spore germination
H0S57_01115	COG0758	DNA mediated transformation
H0S57_01190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S57_01200	COG2814	Major facilitator Superfamily
H0S57_01220	COG1253	flavin adenine dinucleotide binding
H0S57_01225	COG3012	SEC-C Motif Domain Protein
H0S57_01230	COG2860	membrane
H0S57_01235	COG0477	Major facilitator Superfamily
H0S57_01245	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_01260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S57_01280	COG0606	chelatase, subunit chli
H0S57_01290	COG0347	Belongs to the P(II) protein family
H0S57_01295	COG0004	ammonium transporteR
H0S57_01305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S57_01305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0S57_01320	COG0586	Pfam SNARE associated Golgi protein
H0S57_01340	COG0795	lipopolysaccharide-transporting ATPase activity
H0S57_01345	COG0795	lipopolysaccharide-transporting ATPase activity
H0S57_01350	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0S57_01355	COG0793	Belongs to the peptidase S41A family
H0S57_01370	COG2197	response regulator
H0S57_01375	COG1686	Belongs to the peptidase S11 family
H0S57_01380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0S57_01390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S57_01395	COG4974	Belongs to the 'phage' integrase family
H0S57_01415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0S57_01420	COG0772	Belongs to the SEDS family
H0S57_01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S57_01430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S57_01435	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S57_01445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0S57_01475	COG3275	phosphorelay sensor kinase activity
H0S57_01485	COG0181	hydroxymethylbilane synthase activity
H0S57_01550	COG0546	phosphoglycolate phosphatase activity
H0S57_01580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S57_01600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0S57_01605	COG0081	regulation of translation
H0S57_01610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0S57_01615	COG0222	ribosome binding
H0S57_01620	COG0085	RNA polymerase activity
H0S57_01625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0S57_01655	COG2056	Na+-H+ antiporter family
H0S57_01660	COG3047	cAMP biosynthetic process
H0S57_01670	COG0326	Molecular chaperone. Has ATPase activity
H0S57_01700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S57_01770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S57_01775	COG1132	(ABC) transporter
H0S57_01790	COG1289	transmembrane transporter activity
H0S57_01805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0S57_01810	COG1678	Uncharacterized ACR, COG1678
H0S57_01815	COG0497	DNA recombination
H0S57_01825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S57_01835	COG0237	dephospho-CoA kinase activity
H0S57_01895	COG0195	Participates in both transcription termination and antitermination
H0S57_01905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0S57_01910	COG1320	monovalent cation:proton antiporter activity
H0S57_01915	COG2212	antiporter activity
H0S57_01920	COG1863	multisubunit Na H antiporter MnhE subunit
H0S57_01925	COG0651	ATP synthesis coupled electron transport
H0S57_01930	COG1006	Multisubunit Na H antiporter MnhC subunit
H0S57_01935	COG2111	Na H antiporter
H0S57_01935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S57_01940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0S57_01950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S57_01970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S57_02000	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S57_02005	COG1074	ATP-dependent DNA helicase activity
H0S57_02010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S57_02015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S57_02025	COG1185	polyribonucleotide nucleotidyltransferase activity
H0S57_02030	COG0598	Magnesium transport protein CorA
H0S57_02035	COG2841	Protein conserved in bacteria
H0S57_02055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H0S57_02065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0S57_02085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S57_02090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0S57_02095	COG4535	Mg2 and Co2 transporter CorC
H0S57_02100	COG0425	Belongs to the sulfur carrier protein TusA family
H0S57_02120	COG0644	oxidoreductase
H0S57_02120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H0S57_02130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S57_02140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H0S57_02145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S57_02150	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H0S57_02160	COG0493	'glutamate synthase
H0S57_02160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S57_02190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0S57_02220	COG0751	glycine-tRNA ligase activity
H0S57_02240	COG1983	PspC domain protein
H0S57_02265	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_02270	COG1530	ribonuclease E activity
H0S57_02280	COG0546	phosphoglycolate phosphatase activity
H0S57_02290	COG0583	DNA-binding transcription factor activity
H0S57_02320	COG1960	acyl-CoA dehydrogenase activity
H0S57_02335	COG1280	lysine exporter protein (LysE YggA)
H0S57_02370	COG0583	DNA-binding transcription factor activity
H0S57_02380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0S57_02395	COG0473	3-isopropylmalate dehydrogenase activity
H0S57_02450	COG1560	Kdo2-lipid A biosynthetic process
H0S57_02455	COG0488	(ABC) transporter
H0S57_02460	COG2900	Belongs to the SlyX family
H0S57_02500	COG1929	Belongs to the glycerate kinase type-1 family
H0S57_02505	COG0210	DNA helicase
H0S57_02530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S57_02530	COG4651	solute:proton antiporter activity
H0S57_02555	COG0788	formyltetrahydrofolate deformylase activity
H0S57_02665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S57_02665	COG2813	Specifically methylates the guanine in position
H0S57_02675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S57_02690	COG4774	siderophore transport
H0S57_02695	COG4771	TonB-dependent receptor
H0S57_02705	COG0740	serine-type endopeptidase activity
H0S57_02725	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S57_02725	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S57_02730	COG2207	Transcriptional regulator
H0S57_02730	COG1917	Cupin 2, conserved barrel domain protein
H0S57_02740	COG2318	DinB family
H0S57_02750	COG0857	belongs to the CobB CobQ family
H0S57_02750	COG0280	phosphate acetyltransferase
H0S57_02755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S57_02760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0S57_02780	COG0793	Belongs to the peptidase S41A family
H0S57_02790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H0S57_02805	COG0084	hydrolase, TatD family'
H0S57_02815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H0S57_02835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0S57_02910	COG3646	Phage regulatory protein
H0S57_03060	COG4695	Portal protein
H0S57_03080	COG2814	Major facilitator Superfamily
H0S57_03105	COG0004	ammonium transporteR
H0S57_03120	COG3622	Belongs to the hyi family
H0S57_03125	COG2084	Dehydrogenase
H0S57_03130	COG1024	Enoyl-CoA hydratase
H0S57_03135	COG5002	protein histidine kinase activity
H0S57_03135	COG2205	protein histidine kinase activity
H0S57_03135	COG0784	Response regulator, receiver
H0S57_03140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S57_03155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S57_03160	COG0300	oxidoreductase activity
H0S57_03165	COG3956	TIGRFAM MazG family protein
H0S57_03170	COG1555	photosystem II stabilization
H0S57_03175	COG0617	tRNA 3'-terminal CCA addition
H0S57_03180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0S57_03190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0S57_03195	COG1660	Displays ATPase and GTPase activities
H0S57_03205	COG3028	Belongs to the UPF0307 family
H0S57_03210	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_03230	COG0625	glutathione transferase activity
H0S57_03240	COG1238	metal cluster binding
H0S57_03290	COG0072	phenylalanine-tRNA ligase activity
H0S57_03315	COG0248	Ppx GppA phosphatase
H0S57_03325	COG0037	tRNA processing
H0S57_03340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S57_03340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0S57_03370	COG1764	response to oxidative stress
H0S57_03375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_03385	COG2208	phosphoserine phosphatase activity
H0S57_03390	COG2853	Lipoprotein
H0S57_03420	COG2814	Major facilitator Superfamily
H0S57_03460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S57_03470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S57_03495	COG0494	nUDIX hydrolase
H0S57_03500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S57_03505	COG1214	PFAM Peptidase M22, glycoprotease
H0S57_03510	COG1968	undecaprenyl-diphosphatase activity
H0S57_03525	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H0S57_03545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0S57_03555	COG2132	Multicopper oxidase
H0S57_03580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S57_03590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S57_03590	COG0352	thiamine-phosphate diphosphorylase activity
H0S57_03590	COG0351	phosphomethylpyrimidine kinase
H0S57_03620	COG0251	oxidation-reduction process
H0S57_03625	COG1113	amino acid transport
H0S57_03635	COG1981	membrane
H0S57_03650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S57_03665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0S57_03675	COG0456	acetyltransferase
H0S57_03685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0S57_03690	COG0492	ferredoxin-NADP+ reductase activity
H0S57_03695	COG1674	ftsk spoiiie
H0S57_03695	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0S57_03710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H0S57_03715	COG2894	cell division
H0S57_03720	COG0850	regulation of cytokinetic process
H0S57_03730	COG0204	Acyl-transferase
H0S57_03735	COG2885	chlorophyll binding
H0S57_03740	COG0210	DNA helicase
H0S57_03745	COG0756	dUTP diphosphatase activity
H0S57_03760	COG0121	glutamine amidotransferase
H0S57_03775	COG2914	Belongs to the UPF0125 (RnfH) family
H0S57_03780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S57_03785	COG0735	belongs to the Fur family
H0S57_03815	COG0420	3'-5' exonuclease activity
H0S57_03820	COG4251	negative regulation of phosphorylation
H0S57_03820	COG3706	GGDEF domain
H0S57_03820	COG2203	Gaf domain
H0S57_03820	COG5001	Diguanylate cyclase
H0S57_03830	COG1090	epimerase
H0S57_03845	COG2050	protein possibly involved in aromatic compounds catabolism
H0S57_03850	COG1566	PFAM secretion protein HlyD family protein
H0S57_03855	COG2814	Major facilitator Superfamily
H0S57_03860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0S57_03870	COG0582	viral genome integration into host DNA
H0S57_04025	COG0515	serine threonine protein kinase
H0S57_04025	COG2815	serine threonine protein kinase
H0S57_04035	COG0514	ATP-dependent DNA helicase (RecQ)
H0S57_04040	COG0582	viral genome integration into host DNA
H0S57_04090	COG2184	nucleotidyltransferase activity
H0S57_04215	COG3177	Filamentation induced by cAMP protein fic
H0S57_04245	COG4221	oxidoreductase activity
H0S57_04250	COG0583	DNA-binding transcription factor activity
H0S57_04255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S57_04260	COG3321	synthase
H0S57_04260	COG0604	alcohol dehydrogenase
H0S57_04275	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H0S57_04290	COG4772	TonB-dependent receptor
H0S57_04300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S57_04310	COG0583	DNA-binding transcription factor activity
H0S57_04315	COG2610	gluconate transmembrane transporter activity
H0S57_04320	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_04335	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0S57_04370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S57_04380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S57_04385	COG1077	Cell shape determining protein MreB Mrl
H0S57_04390	COG1792	Involved in formation and maintenance of cell shape
H0S57_04395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H0S57_04400	COG0424	maF-like protein
H0S57_04415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S57_04470	COG0640	Transcriptional regulator
H0S57_04480	COG0798	PFAM Bile acid sodium symporter
H0S57_04485	COG0431	NADPH-dependent FMN reductase
H0S57_04500	COG0625	glutathione transferase activity
H0S57_04520	COG1113	amino acid transport
H0S57_04535	COG1113	amino acid transport
H0S57_04540	COG2828	Protein conserved in bacteria
H0S57_04545	COG0142	geranyltranstransferase activity
H0S57_04560	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S57_04585	COG0745	RESPONSE REGULATOR receiver
H0S57_04590	COG0642	Histidine kinase
H0S57_04605	COG0004	ammonium transporteR
H0S57_04615	COG1126	abc transporter atp-binding protein
H0S57_04620	COG0765	amino acid transport
H0S57_04625	COG0765	amino acid transport
H0S57_04645	COG0668	transmembrane transport
H0S57_04660	COG2081	HI0933 family
H0S57_04665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H0S57_04700	COG4716	Myosin-crossreactive antigen
H0S57_04725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S57_04745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S57_04745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S57_04770	COG0489	protein tyrosine kinase activity
H0S57_04785	COG2358	TRAP transporter, solute receptor (TAXI family
H0S57_04830	COG1566	PFAM secretion protein HlyD family protein
H0S57_04855	COG0840	transmembrane signaling receptor activity
H0S57_04860	COG0784	Response regulator, receiver
H0S57_04860	COG2198	Histidine kinase
H0S57_04860	COG0643	Histidine kinase
H0S57_04870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0S57_04885	COG2832	Protein of unknown function (DUF454)
H0S57_04955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0S57_04965	COG1289	transmembrane transporter activity
H0S57_04985	COG0786	glutamate:sodium symporter activity
H0S57_04990	COG1115	amino acid carrier protein
H0S57_05000	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S57_05005	COG1607	acyl-coa hydrolase
H0S57_05015	COG0523	cobalamin synthesis protein
H0S57_05020	COG4681	YaeQ
H0S57_05030	COG2199	diguanylate cyclase activity
H0S57_05030	COG2203	Gaf domain
H0S57_05075	COG0477	Major facilitator Superfamily
H0S57_05080	COG0242	peptide deformylase activity
H0S57_05085	COG2207	Transcriptional regulator
H0S57_05090	COG2223	nitrite transmembrane transporter activity
H0S57_05110	COG0515	serine threonine protein kinase
H0S57_05110	COG2815	serine threonine protein kinase
H0S57_05120	COG0306	phosphate transporter
H0S57_05170	COG4181	ATPase activity
H0S57_05175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H0S57_05195	COG0583	DNA-binding transcription factor activity
H0S57_05205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_05210	COG1773	rubredoxin
H0S57_05215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0S57_05245	COG0210	DNA helicase
H0S57_05255	COG1695	Transcriptional regulator
H0S57_05270	COG4221	oxidoreductase activity
H0S57_05270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H0S57_05270	COG0604	alcohol dehydrogenase
H0S57_05270	COG3321	synthase
H0S57_05295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0S57_05310	COG0477	Major facilitator Superfamily
H0S57_05325	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H0S57_05330	COG1597	lipid kinase activity
H0S57_05350	COG0641	radical SAM
H0S57_05355	COG3119	arylsulfatase activity
H0S57_05380	COG0742	ribosomal rna small subunit methyltransferase
H0S57_05385	COG0768	penicillin binding
H0S57_05410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0S57_05415	COG2878	Part of a membrane complex involved in electron transport
H0S57_05420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0S57_05430	COG3384	dioxygenase
H0S57_05440	COG2234	aminopeptidase activity
H0S57_05455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0S57_05465	COG2217	Heavy metal translocating P-type atpase
H0S57_05475	COG1914	H( )-stimulated, divalent metal cation uptake system
H0S57_05495	COG4770	biotin carboxylase activity
H0S57_05520	COG0006	proline dipeptidase activity
H0S57_05535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S57_05540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H0S57_05560	COG2915	High frequency lysogenization protein hflD homolog
H0S57_05580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0S57_05585	COG1686	Belongs to the peptidase S11 family
H0S57_05600	COG0789	Transcriptional regulator
H0S57_05615	COG0753	catalase activity
H0S57_05770	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
H0S57_05980	COG0582	viral genome integration into host DNA
H0S57_05995	COG0583	DNA-binding transcription factor activity
H0S57_06015	COG0657	acetylesterase activity
H0S57_06020	COG2816	NAD+ diphosphatase activity
H0S57_06030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S57_06035	COG1388	LysM domain
H0S57_06035	COG0741	lytic transglycosylase activity
H0S57_06040	COG4166	transmembrane transport
H0S57_06045	COG4174	ABC transporter (Permease)
H0S57_06050	COG4239	(ABC) transporter, permease
H0S57_06055	COG4172	Belongs to the ABC transporter superfamily
H0S57_06070	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H0S57_06095	COG0833	amino acid
H0S57_06125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H0S57_06130	COG0418	dihydroorotase activity
H0S57_06135	COG3706	GGDEF domain
H0S57_06135	COG5001	Diguanylate cyclase
H0S57_06135	COG4251	negative regulation of phosphorylation
H0S57_06135	COG2203	Gaf domain
H0S57_06150	COG2186	Transcriptional regulator
H0S57_06160	COG0277	FAD linked oxidase domain protein
H0S57_06165	COG1902	pentaerythritol trinitrate reductase activity
H0S57_06165	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S57_06195	COG0281	malic enzyme
H0S57_06195	COG0280	phosphate acetyltransferase
H0S57_06200	COG1716	ATPase activity
H0S57_06200	COG5001	Diguanylate cyclase
H0S57_06205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S57_06210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0S57_06215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S57_06255	COG1960	acyl-CoA dehydrogenase activity
H0S57_06260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S57_06265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S57_06280	COG1671	Belongs to the UPF0178 family
H0S57_06295	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0S57_06300	COG1136	(ABC) transporter
H0S57_06305	COG2333	competence protein COMEC
H0S57_06305	COG0658	competence protein
H0S57_06325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0S57_06330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0S57_06335	COG0628	permease
H0S57_06340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S57_06370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S57_06390	COG0823	Involved in the tonB-independent uptake of proteins
H0S57_06410	COG0824	Thioesterase
H0S57_06425	COG2255	four-way junction helicase activity
H0S57_06440	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S57_06440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S57_06455	COG3328	transposase activity
H0S57_06460	COG3323	Protein of unknown function (DUF1653)
H0S57_06460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S57_06480	COG1024	Enoyl-CoA hydratase
H0S57_06485	COG1051	belongs to the nudix hydrolase family
H0S57_06485	COG1056	cytidyltransferase-related domain
H0S57_06490	COG2353	YceI-like domain
H0S57_06495	COG0583	DNA-binding transcription factor activity
H0S57_06505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S57_06520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0S57_06525	COG0602	queuosine metabolic process
H0S57_06545	COG0583	DNA-binding transcription factor activity
H0S57_06550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H0S57_06555	COG4208	sulfate ABC transporter
H0S57_06570	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S57_06580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S57_06600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S57_06615	COG0681	Belongs to the peptidase S26 family
H0S57_06630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0S57_06640	COG1381	Involved in DNA repair and RecF pathway recombination
H0S57_06645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0S57_06680	COG0436	Aminotransferase
H0S57_06690	COG2199	diguanylate cyclase activity
H0S57_06705	COG0556	nucleotide-excision repair
H0S57_06735	COG0702	epimerase
H0S57_06740	COG1733	regulation of RNA biosynthetic process
H0S57_06750	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H0S57_06755	COG0671	phosphoesterase, PA-phosphatase related
H0S57_06770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H0S57_06775	COG0076	glutamate decarboxylase activity
H0S57_06780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S57_06785	COG0573	inorganic phosphate transmembrane transporter activity
H0S57_06795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S57_06800	COG0616	signal peptide processing
H0S57_06805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S57_06810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S57_06815	COG1067	ATP-dependent peptidase activity
H0S57_06835	COG0254	rRNA binding
H0S57_06855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S57_06860	COG1966	Carbon starvation protein
H0S57_06865	COG2879	small protein
H0S57_06885	COG0714	Associated with various cellular activities
H0S57_06925	COG1538	Outer membrane efflux protein
H0S57_06960	COG1131	(ABC) transporter
H0S57_06965	COG0842	Transport permease protein
H0S57_06970	COG0842	Transport permease protein
H0S57_06995	COG1309	transcriptional regulator
H0S57_07065	COG1733	regulation of RNA biosynthetic process
H0S57_07070	COG0604	alcohol dehydrogenase
H0S57_07085	COG1278	Cold shock
H0S57_07105	COG3038	cytochrome b561
H0S57_07115	COG2070	2-Nitropropane dioxygenase
H0S57_07140	COG3634	alkyl hydroperoxide reductase activity
H0S57_07160	COG0436	Aminotransferase
H0S57_07165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_07170	COG0386	Belongs to the glutathione peroxidase family
H0S57_07190	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0S57_07205	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S57_07230	COG0012	GTP binding
H0S57_07240	COG2011	ABC-type metal ion transport system permease component
H0S57_07245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S57_07250	COG1464	Belongs to the NlpA lipoprotein family
H0S57_07255	COG1464	Belongs to the NlpA lipoprotein family
H0S57_07300	COG3293	Transposase
H0S57_07345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_07350	COG0183	Belongs to the thiolase family
H0S57_07370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_07375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H0S57_07380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_07400	COG1484	DNA-dependent DNA replication
H0S57_07500	COG2009	succinate dehydrogenase
H0S57_07510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H0S57_07520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H0S57_07555	COG0625	glutathione transferase activity
H0S57_07560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S57_07615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S57_07660	COG0582	viral genome integration into host DNA
H0S57_07700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S57_07705	COG0730	response to heat
H0S57_07725	COG4773	Receptor
H0S57_07730	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S57_07735	COG1944	ATP diphosphatase activity
H0S57_07740	COG2207	Transcriptional regulator
H0S57_07745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S57_07750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S57_07780	COG2223	nitrite transmembrane transporter activity
H0S57_07795	COG1346	cytolysis
H0S57_07800	COG1380	Effector of murein hydrolase LrgA
H0S57_07825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S57_08085	COG4387	Mu-like prophage protein GP36
H0S57_08175	COG3772	lysozyme
H0S57_08190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S57_08260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S57_08265	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H0S57_08280	COG3300	MHYT domain
H0S57_08280	COG5001	Diguanylate cyclase
H0S57_08285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H0S57_08295	COG2814	Major facilitator Superfamily
H0S57_08310	COG1132	(ABC) transporter
H0S57_08320	COG0668	transmembrane transport
H0S57_08325	COG3122	Protein conserved in bacteria
H0S57_08345	COG0640	Transcriptional regulator
H0S57_08350	COG0596	Alpha beta hydrolase
H0S57_08355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S57_08360	COG1335	isochorismatase
H0S57_08365	COG0251	oxidation-reduction process
H0S57_08370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_08375	COG2233	PERMEase
H0S57_08385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S57_08395	COG0183	Belongs to the thiolase family
H0S57_08400	COG0583	DNA-binding transcription factor activity
H0S57_08415	COG0439	Biotin carboxylase
H0S57_08430	COG0511	ligase activity, forming carbon-carbon bonds
H0S57_08440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S57_08445	COG0183	Belongs to the thiolase family
H0S57_08450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S57_08455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H0S57_08460	COG3135	benzoate transporter
H0S57_08465	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_08470	COG0543	2 iron, 2 sulfur cluster binding
H0S57_08470	COG0633	Ferredoxin
H0S57_08475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H0S57_08480	COG4638	Rieske (2fe-2S)
H0S57_08490	COG4829	muconolactone delta-isomerase
H0S57_08495	COG4948	Mandelate Racemase Muconate Lactonizing
H0S57_08500	COG0583	DNA-binding transcription factor activity
H0S57_08505	COG2814	Major facilitator Superfamily
H0S57_08595	COG0583	DNA-binding transcription factor activity
H0S57_08685	COG0596	Alpha beta hydrolase
H0S57_08755	COG0864	Transcriptional regulator
H0S57_08780	COG2814	Major facilitator Superfamily
H0S57_08835	COG1960	acyl-CoA dehydrogenase activity
H0S57_08840	COG1960	acyl-CoA dehydrogenase activity
H0S57_08880	COG3293	Transposase
H0S57_08900	COG0552	protein localization to endoplasmic reticulum
H0S57_08905	COG0612	Peptidase, M16
H0S57_08935	COG0517	IMP dehydrogenase activity
H0S57_08935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S57_08940	COG0133	tryptophan synthase activity
H0S57_08950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S57_08965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H0S57_08970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S57_09005	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_09015	COG0537	adenosine 5'-monophosphoramidase activity
H0S57_09040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S57_09045	COG0776	regulation of translation
H0S57_09060	COG1959	2 iron, 2 sulfur cluster binding
H0S57_09070	COG0822	iron-sulfur transferase activity
H0S57_09075	COG0316	Belongs to the HesB IscA family
H0S57_09105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0S57_09115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S57_09130	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S57_09130	COG0506	proline dehydrogenase activity
H0S57_09130	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H0S57_09160	COG3781	membrane
H0S57_09165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S57_09190	COG0697	spore germination
H0S57_09205	COG0126	phosphoglycerate kinase activity
H0S57_09215	COG0424	maF-like protein
H0S57_09225	COG2850	peptidyl-arginine hydroxylation
H0S57_09230	COG4585	Histidine kinase
H0S57_09235	COG2197	response regulator
H0S57_09265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S57_09275	COG0824	Thioesterase
H0S57_09280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0S57_09300	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_09305	COG0183	Belongs to the thiolase family
H0S57_09320	COG0583	DNA-binding transcription factor activity
H0S57_09325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S57_09335	COG3135	benzoate transporter
H0S57_09340	COG1309	transcriptional regulator
H0S57_09345	COG2076	Multidrug Resistance protein
H0S57_09360	COG0589	response to stress
H0S57_09370	COG0308	aminopeptidase N
H0S57_09395	COG1253	flavin adenine dinucleotide binding
H0S57_09415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H0S57_09420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H0S57_09435	COG2431	L-lysine efflux transmembrane transporter activity
H0S57_09460	COG0776	regulation of translation
H0S57_09480	COG0590	tRNA wobble adenosine to inosine editing
H0S57_09490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0S57_09500	COG3156	type II secretion system protein K
H0S57_09525	COG0084	hydrolase, TatD family'
H0S57_09545	COG1663	tetraacyldisaccharide 4'-kinase activity
H0S57_09550	COG1132	(ABC) transporter
H0S57_09560	COG0811	peptide transport
H0S57_09565	COG1475	DNA binding
H0S57_09570	COG1192	Involved in chromosome partitioning
H0S57_09580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0S57_09595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S57_09600	COG3293	Transposase
H0S57_09605	COG1923	regulation of RNA biosynthetic process
H0S57_09615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0S57_09620	COG0802	atpase or kinase
H0S57_09625	COG0564	pseudouridine synthase activity
H0S57_09645	COG2707	UPF0756 membrane protein
H0S57_09650	COG2814	Major facilitator Superfamily
H0S57_09655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H0S57_09660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0S57_09670	COG1454	alcohol dehydrogenase
H0S57_09690	COG0531	amino acid
H0S57_09695	COG4303	Ethanolamine ammonia lyase large subunit
H0S57_09700	COG4302	ethanolamine ammonia-lyase activity
H0S57_09710	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_09720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S57_09720	COG0519	Catalyzes the synthesis of GMP from XMP
H0S57_09740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0S57_09745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0S57_09790	COG0352	thiamine-phosphate diphosphorylase activity
H0S57_09825	COG0612	Peptidase, M16
H0S57_09835	COG1823	symporter activity
H0S57_09840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_09880	COG2351	hydroxyisourate hydrolase activity
H0S57_09890	COG1686	Belongs to the peptidase S11 family
H0S57_09895	COG1252	NADH dehydrogenase
H0S57_09900	COG1047	Peptidyl-prolyl cis-trans
H0S57_09905	COG1254	Belongs to the acylphosphatase family
H0S57_09910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0S57_09910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0S57_09930	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_09935	COG2819	hydrolase of the alpha beta superfamily
H0S57_09945	COG0372	Belongs to the citrate synthase family
H0S57_09975	COG0542	response to heat
H0S57_09980	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S57_09995	COG3706	GGDEF domain
H0S57_10005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H0S57_10010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0S57_10020	COG0569	domain protein
H0S57_10025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0S57_10045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S57_10055	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S57_10070	COG1294	oxidase, subunit
H0S57_10075	COG4890	Cyd operon protein YbgT
H0S57_10090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S57_10095	COG1309	transcriptional regulator
H0S57_10100	COG1012	belongs to the aldehyde dehydrogenase family
H0S57_10110	COG0579	oxidoreductase
H0S57_10125	COG0772	Belongs to the SEDS family
H0S57_10140	COG0148	phosphopyruvate hydratase activity
H0S57_10160	COG0583	DNA-binding transcription factor activity
H0S57_10170	COG2814	Major facilitator Superfamily
H0S57_10185	COG1902	pentaerythritol trinitrate reductase activity
H0S57_10185	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S57_10195	COG2267	carboxylic ester hydrolase activity
H0S57_10205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H0S57_10210	COG0702	epimerase
H0S57_10255	COG1011	Hydrolase
H0S57_10260	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0S57_10265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0S57_10270	COG2137	regulation of response to DNA damage stimulus
H0S57_10295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0S57_10315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S57_10330	COG0575	Belongs to the CDS family
H0S57_10335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S57_10355	COG3852	Histidine kinase
H0S57_10375	COG0583	DNA-binding transcription factor activity
H0S57_10380	COG0024	Methionine aminopeptidase
H0S57_10405	COG1113	amino acid transport
H0S57_10415	COG0786	glutamate:sodium symporter activity
H0S57_10420	COG4773	Receptor
H0S57_10470	COG0729	surface antigen
H0S57_10495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0S57_10505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0S57_10510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S57_10515	COG1960	acyl-CoA dehydrogenase activity
H0S57_10545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_10550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S57_10555	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S57_10560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S57_10575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S57_10605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S57_10610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S57_10615	COG1845	cytochrome c oxidase, subunit III
H0S57_10620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H0S57_10640	COG0360	Binds together with S18 to 16S ribosomal RNA
H0S57_10655	COG0305	Participates in initiation and elongation during chromosome replication
H0S57_10660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S57_10675	COG1305	Transglutaminase-like
H0S57_10685	COG2308	Evidence 4 Homologs of previously reported genes of
H0S57_10700	COG0445	tRNA wobble uridine modification
H0S57_10730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H0S57_10735	COG0138	bifunctional purine biosynthesis protein purh
H0S57_10740	COG0151	Belongs to the GarS family
H0S57_10750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0S57_10755	COG2011	ABC-type metal ion transport system permease component
H0S57_10795	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H0S57_10805	COG4122	O-methyltransferase activity
H0S57_10825	COG1137	ATPase activity
H0S57_10830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H0S57_10840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0S57_10845	COG0517	IMP dehydrogenase activity
H0S57_10845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0S57_10855	COG0406	alpha-ribazole phosphatase activity
H0S57_10860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S57_10895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S57_10905	COG0243	molybdopterin cofactor binding
H0S57_10910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_10915	COG2146	nitrite reductase [NAD(P)H] activity
H0S57_10915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_10920	COG2223	nitrite transmembrane transporter activity
H0S57_10930	COG1116	anion transmembrane transporter activity
H0S57_10930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S57_10950	COG1643	Atp-dependent helicase
H0S57_10960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S57_11000	COG0515	serine threonine protein kinase
H0S57_11000	COG2815	serine threonine protein kinase
H0S57_11030	COG1610	YqeY-like protein
H0S57_11035	COG4783	chaperone-mediated protein folding
H0S57_11065	COG0167	dihydroorotate dehydrogenase activity
H0S57_11090	COG0778	Nitroreductase
H0S57_11100	COG0513	Belongs to the DEAD box helicase family
H0S57_11105	COG1278	Cold shock
H0S57_11120	COG2363	Small membrane protein
H0S57_11150	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0S57_11155	COG0625	glutathione transferase activity
H0S57_11160	COG0659	secondary active sulfate transmembrane transporter activity
H0S57_11170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S57_11200	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_11205	COG1309	transcriptional regulator
H0S57_11210	COG1960	acyl-CoA dehydrogenase activity
H0S57_11215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S57_11225	COG4770	biotin carboxylase activity
H0S57_11240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H0S57_11245	COG2031	fatty acid transporter
H0S57_11265	COG0540	Belongs to the ATCase OTCase family
H0S57_11285	COG0542	response to heat
H0S57_11290	COG1765	OsmC-like protein
H0S57_11300	COG0667	Aldo Keto reductase
H0S57_11315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S57_11330	COG1522	sequence-specific DNA binding
H0S57_11335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H0S57_11350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S57_11360	COG0527	aspartate kinase activity
H0S57_11370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S57_11395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S57_11400	COG2252	PERMEase
H0S57_11410	COG0415	Belongs to the DNA photolyase family
H0S57_11440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H0S57_11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0S57_11455	COG0693	protein deglycase activity
H0S57_11460	COG1960	acyl-CoA dehydrogenase activity
H0S57_11465	COG1301	dicarboxylic acid transport
H0S57_11480	COG3139	Protein of unknown function (DUF1315)
H0S57_11485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S57_11490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S57_11500	COG0494	nUDIX hydrolase
H0S57_11510	COG0642	Histidine kinase
H0S57_11525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H0S57_11545	COG1720	tRNA m6t6A37 methyltransferase activity
H0S57_11605	COG0826	peptidase U32
H0S57_11610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S57_11615	COG3634	alkyl hydroperoxide reductase activity
H0S57_11635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S57_11700	COG0697	spore germination
H0S57_11705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S57_11710	COG0235	Class ii aldolase
H0S57_11715	COG2169	Transcriptional regulator
H0S57_11760	COG4149	molybdate abc transporter
H0S57_11765	COG0725	ABC transporter, periplasmic molybdate-binding protein
H0S57_11775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0S57_11780	COG0243	molybdopterin cofactor binding
H0S57_11785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0S57_11790	COG0315	cyclic pyranopterin monophosphate synthase activity
H0S57_11790	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0S57_11795	COG0303	'Molybdopterin
H0S57_11815	COG2365	Tyrosine phosphatase family
H0S57_11820	COG3293	Transposase
H0S57_11835	COG1131	(ABC) transporter
H0S57_11840	COG0842	Transport permease protein
H0S57_11855	COG2951	lytic endotransglycosylase activity
H0S57_11890	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S57_11910	COG2175	clavaminate synthase activity
H0S57_11925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S57_11930	COG0842	Transport permease protein
H0S57_11970	COG1522	sequence-specific DNA binding
H0S57_11975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S57_11985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H0S57_11995	COG0019	diaminopimelate decarboxylase activity
H0S57_12005	COG1113	amino acid transport
H0S57_12010	COG1115	amino acid carrier protein
H0S57_12025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S57_12030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0S57_12035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S57_12040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0S57_12080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H0S57_12085	COG3161	chorismate lyase activity
H0S57_12095	COG0174	glutamine synthetase
H0S57_12100	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S57_12105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0S57_12110	COG0134	indole-3-glycerol-phosphate synthase activity
H0S57_12125	COG0318	PFAM AMP-dependent synthetase and ligase
H0S57_12130	COG0300	oxidoreductase activity
H0S57_12140	COG0302	gtp cyclohydrolase
H0S57_12165	COG3739	integral membrane protein
H0S57_12185	COG1741	Belongs to the pirin family
H0S57_12200	COG1309	transcriptional regulator
H0S57_12210	COG5006	permease, DMT superfamily
H0S57_12215	COG0697	spore germination
H0S57_12235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S57_12240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H0S57_12250	COG0037	tRNA processing
H0S57_12255	COG0741	lytic transglycosylase activity
H0S57_12260	COG0501	Belongs to the peptidase M48B family
H0S57_12275	COG2239	Acts as a magnesium transporter
H0S57_12305	COG1253	flavin adenine dinucleotide binding
H0S57_12310	COG2851	Citrate transporter
H0S57_12350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S57_12355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S57_12380	COG0505	Belongs to the CarA family
H0S57_12385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0S57_12410	COG3695	enzyme binding
H0S57_12425	COG2321	neutral zinc metallopeptidase
H0S57_12430	COG2354	Protein conserved in bacteria
H0S57_12440	COG1585	Membrane protein implicated in regulation of membrane protease activity
H0S57_12445	COG2268	Band 7 protein
H0S57_12455	COG1649	PFAM Uncharacterised BCR, COG1649
H0S57_12455	COG0726	polysaccharide deacetylase
H0S57_12465	COG1215	transferase activity, transferring glycosyl groups
H0S57_12470	COG0726	polysaccharide deacetylase
H0S57_12470	COG1649	PFAM Uncharacterised BCR, COG1649
H0S57_12480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0S57_12490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S57_12505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S57_12510	COG1053	succinate dehydrogenase
H0S57_12515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H0S57_12520	COG2009	succinate dehydrogenase
H0S57_12535	COG0300	oxidoreductase activity
H0S57_12550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S57_12550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0S57_12575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0S57_12600	COG0564	pseudouridine synthase activity
H0S57_12610	COG0358	DNA primase activity
H0S57_12625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H0S57_12655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S57_12660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0S57_12710	COG0586	Pfam SNARE associated Golgi protein
H0S57_12720	COG0583	DNA-binding transcription factor activity
H0S57_12745	COG2921	Belongs to the UPF0250 family
H0S57_12750	COG0321	lipoyl(octanoyl) transferase activity
H0S57_12770	COG0531	amino acid
H0S57_12790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0S57_12795	COG1648	precorrin-2 dehydrogenase activity
H0S57_12795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S57_12800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0S57_12810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0S57_12820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0S57_12840	COG0671	phosphoesterase, PA-phosphatase related
H0S57_12845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S57_12855	COG1538	Outer membrane efflux protein
H0S57_12860	COG0393	Putative heavy-metal-binding
H0S57_12875	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_12885	COG0525	valine-tRNA ligase activity
H0S57_12925	COG0583	DNA-binding transcription factor activity
H0S57_12930	COG1278	Cold shock
H0S57_12935	COG1278	Cold shock
H0S57_12950	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S57_12955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0S57_12960	COG0713	ATP synthesis coupled electron transport
H0S57_12970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S57_12985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S57_13005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S57_13015	COG2205	protein histidine kinase activity
H0S57_13020	COG0745	RESPONSE REGULATOR receiver
H0S57_13035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0S57_13055	COG0535	radical SAM domain protein
H0S57_13160	COG0439	Biotin carboxylase
H0S57_13165	COG1802	Transcriptional regulator
H0S57_13170	COG1652	LysM domain
H0S57_13180	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_13195	COG1399	metal-binding, possibly nucleic acid-binding protein
H0S57_13200	COG3101	peptidyl-lysine hydroxylation
H0S57_13205	COG0009	L-threonylcarbamoyladenylate synthase
H0S57_13220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H0S57_13225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0S57_13265	COG4206	TonB-dependent receptor
H0S57_13295	COG4106	trans-aconitate 2-methyltransferase activity
H0S57_13310	COG2267	carboxylic ester hydrolase activity
H0S57_13315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0S57_13320	COG2193	ferroxidase activity
H0S57_13340	COG4774	siderophore transport
H0S57_13345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S57_13350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0S57_13355	COG3115	cell septum assembly
H0S57_13360	COG1196	nuclear chromosome segregation
H0S57_13370	COG0730	response to heat
H0S57_13390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0S57_13405	COG0488	(ABC) transporter
H0S57_13420	COG0494	nUDIX hydrolase
H0S57_13430	COG3422	double-strand break repair
H0S57_13440	COG2824	Alkylphosphonate utilization operon protein PhnA
H0S57_13445	COG3189	MarR family transcriptional regulator
H0S57_13465	COG0564	pseudouridine synthase activity
H0S57_13470	COG0346	lactoylglutathione lyase activity
H0S57_13515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S57_13545	COG1902	pentaerythritol trinitrate reductase activity
H0S57_13550	COG3659	wide pore channel activity
H0S57_13560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0S57_13570	COG1970	mechanosensitive ion channel activity
H0S57_13575	COG1217	gtp-binding protein TYPA
H0S57_13580	COG2233	PERMEase
H0S57_13585	COG2813	Specifically methylates the guanine in position
H0S57_13590	COG0833	amino acid
H0S57_13605	COG0183	Belongs to the thiolase family
H0S57_13630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S57_13645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S57_13650	COG2207	Transcriptional regulator
H0S57_13655	COG0183	Belongs to the thiolase family
H0S57_13660	COG1024	Enoyl-CoA hydratase
H0S57_13660	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S57_13685	COG1272	protein, Hemolysin III
H0S57_13690	COG0477	Major facilitator Superfamily
H0S57_13700	COG1408	metallophosphoesterase
H0S57_13705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S57_13715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S57_13740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H0S57_13745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S57_13750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0S57_13755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S57_13760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S57_13770	COG0625	glutathione transferase activity
H0S57_13775	COG2969	positive regulation of protein catabolic process
H0S57_13835	COG2199	diguanylate cyclase activity
H0S57_13865	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S57_13870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S57_13890	COG0450	alkyl hydroperoxide reductase
H0S57_13910	COG0285	dihydrofolate synthase activity
H0S57_13960	COG4206	TonB-dependent receptor
H0S57_13965	COG2096	Adenosyltransferase
H0S57_13985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H0S57_13990	COG2315	Protein conserved in bacteria
H0S57_14005	COG1113	amino acid transport
H0S57_14010	COG0745	RESPONSE REGULATOR receiver
H0S57_14015	COG2205	protein histidine kinase activity
H0S57_14025	COG1960	acyl-CoA dehydrogenase activity
H0S57_14030	COG1960	acyl-CoA dehydrogenase activity
H0S57_14035	COG3223	Belongs to the PsiE family
H0S57_14070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0S57_14095	COG3306	glycosyltransferase involved in LPS biosynthesis
H0S57_14120	COG0438	transferase activity, transferring glycosyl groups
H0S57_14155	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S57_14160	COG5002	protein histidine kinase activity
H0S57_14170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0S57_14180	COG1704	LemA family
H0S57_14190	COG1862	Preprotein translocase
H0S57_14215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0S57_14235	COG1426	Protein conserved in bacteria
H0S57_14295	COG0440	acetolactate synthase activity
H0S57_14300	COG0028	Belongs to the TPP enzyme family
H0S57_14325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0S57_14330	COG1136	(ABC) transporter
H0S57_14330	COG0577	efflux transmembrane transporter activity
H0S57_14335	COG1538	Outer membrane efflux protein
H0S57_14370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H0S57_14375	COG1162	GTPase activity
H0S57_14400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0S57_14410	COG3781	membrane
H0S57_14415	COG0613	PHP domain protein
H0S57_14425	COG2350	Protein conserved in bacteria
H0S57_14445	COG1666	GTP binding
H0S57_14460	COG1607	acyl-coa hydrolase
H0S57_14520	COG1183	phosphatidylcholine synthase activity
H0S57_14525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H0S57_14550	COG0039	L-malate dehydrogenase activity
H0S57_14560	COG0739	heme binding
H0S57_14560	COG1196	nuclear chromosome segregation
H0S57_14560	COG0741	lytic transglycosylase activity
H0S57_14565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S57_14570	COG1702	phosphate starvation-inducible protein PhoH
H0S57_14575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0S57_14605	COG3293	Transposase
H0S57_14625	COG1295	ribonuclease BN
H0S57_14640	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S57_14675	COG0557	exoribonuclease II activity
H0S57_14680	COG2720	vancomycin resistance protein
H0S57_14685	COG0339	signal peptide processing
H0S57_14690	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H0S57_14730	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H0S57_14735	COG1960	acyl-CoA dehydrogenase activity
H0S57_14740	COG2267	carboxylic ester hydrolase activity
H0S57_14745	COG2072	flavoprotein involved in K transport
H0S57_14750	COG0203	ribosomal protein L17
H0S57_14755	COG0202	RNA polymerase activity
H0S57_14770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0S57_14795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0S57_14805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0S57_14810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0S57_14860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0S57_14875	COG0088	Forms part of the polypeptide exit tunnel
H0S57_14880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0S57_14900	COG0433	COG0433 Predicted ATPase
H0S57_14910	COG1959	2 iron, 2 sulfur cluster binding
H0S57_14925	COG1301	dicarboxylic acid transport
H0S57_14930	COG1946	Acyl-CoA thioesterase
H0S57_14935	COG2937	Belongs to the GPAT DAPAT family
H0S57_14945	COG3293	Transposase
H0S57_14970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0S57_14975	COG1040	competence protein
H0S57_14980	COG0494	nUDIX hydrolase
H0S57_14990	COG0598	Magnesium transport protein CorA
H0S57_15000	COG2854	intermembrane phospholipid transfer
H0S57_15005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0S57_15010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S57_15015	COG1127	ABC transporter
H0S57_15020	COG0513	Belongs to the DEAD box helicase family
H0S57_15040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S57_15045	COG0408	coproporphyrinogen oxidase activity
H0S57_15065	COG1960	acyl-CoA dehydrogenase activity
H0S57_15100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0S57_15110	COG0534	Mate efflux family protein
H0S57_15120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S57_15125	COG0254	rRNA binding
H0S57_15130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S57_15145	COG2226	methyltransferase
H0S57_15155	COG1192	Involved in chromosome partitioning
H0S57_15160	COG0628	permease
H0S57_15165	COG2032	superoxide dismutase activity
H0S57_15170	COG1289	transmembrane transporter activity
H0S57_15175	COG2814	Major facilitator Superfamily
H0S57_15190	COG2131	deaminase
H0S57_15195	COG3293	Transposase
H0S57_15210	COG0277	FAD linked oxidase domain protein
H0S57_15215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S57_15220	COG5006	permease, DMT superfamily
H0S57_15240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0S57_15245	COG5380	lipid catabolic process
H0S57_15260	COG0335	large ribosomal subunit rRNA binding
H0S57_15270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S57_15315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H0S57_15320	COG0194	GDP metabolic process
H0S57_15325	COG1758	RNA polymerase activity
H0S57_15330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0S57_15350	COG3307	-O-antigen
H0S57_15370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H0S57_15375	COG1704	LemA family
H0S57_15385	COG0493	'glutamate synthase
H0S57_15390	COG0070	glutamate synthase
H0S57_15390	COG0069	glutamate synthase activity
H0S57_15390	COG0067	glutamate synthase
H0S57_15440	COG2226	methyltransferase
H0S57_15450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S57_15455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S57_15475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S57_15490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S57_15510	COG0488	(ABC) transporter
H0S57_15515	COG2873	o-acetylhomoserine
H0S57_15520	COG4221	oxidoreductase activity
H0S57_15550	COG0427	acetyl-CoA hydrolase
H0S57_15585	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S57_15615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S57_15620	COG0531	amino acid
H0S57_15645	COG1278	Cold shock
H0S57_15650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H0S57_15710	COG2132	Multicopper oxidase
H0S57_15725	COG2205	protein histidine kinase activity
H0S57_15765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H0S57_15770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H0S57_15800	COG3293	Transposase
H0S57_15805	COG0753	catalase activity
H0S57_15815	COG3077	Addiction module antitoxin, RelB DinJ family
H0S57_15850	COG3842	ATPase activity
H0S57_15855	COG1840	ABC-type Fe3 transport system, periplasmic component
H0S57_15965	COG0582	viral genome integration into host DNA
H0S57_16010	COG4942	peptidase
H0S57_16075	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H0S57_16085	COG1335	isochorismatase
H0S57_16115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_16130	COG1301	dicarboxylic acid transport
H0S57_16135	COG0583	DNA-binding transcription factor activity
H0S57_16145	COG0629	single-stranded DNA binding
H0S57_16180	COG3293	Transposase
H0S57_16185	COG0629	single-stranded DNA binding
H0S57_16190	COG2814	Major facilitator Superfamily
H0S57_16200	COG0352	thiamine-phosphate diphosphorylase activity
H0S57_16200	COG0351	phosphomethylpyrimidine kinase
H0S57_16200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0S57_16225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S57_16235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0S57_16240	COG3162	membrane
H0S57_16245	COG0784	Response regulator, receiver
H0S57_16245	COG2205	protein histidine kinase activity
H0S57_16260	COG0431	NADPH-dependent FMN reductase
H0S57_16275	COG1028	Short-chain dehydrogenase reductase Sdr
H0S57_16280	COG0307	riboflavin synthase, alpha
H0S57_16285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S57_16290	COG0668	transmembrane transport
H0S57_16295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0S57_16300	COG1519	Transferase
H0S57_16305	COG1902	pentaerythritol trinitrate reductase activity
H0S57_16330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H0S57_16355	COG0426	domain, Protein
H0S57_16355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S57_16360	COG2119	membrane
H0S57_16390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0S57_16400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H0S57_16410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S57_16425	COG0189	ligase activity
H0S57_16430	COG0386	Belongs to the glutathione peroxidase family
H0S57_16435	COG1846	Transcriptional regulator
H0S57_16450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S57_16460	COG0708	Exodeoxyribonuclease III
H0S57_16465	COG1393	Belongs to the ArsC family
H0S57_16480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H0S57_16565	COG3150	esterase
H0S57_16575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H0S57_16580	COG2918	glutathione biosynthetic process
H0S57_16595	COG2733	membrane
H0S57_16600	COG0436	Aminotransferase
H0S57_16605	COG0534	Mate efflux family protein
H0S57_16680	COG0385	Bile acid
H0S57_16685	COG1335	isochorismatase
H0S57_16690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S57_16705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S57_16710	COG4215	(ABC) transporter
H0S57_16715	COG4160	amino acid transport
H0S57_16735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0S57_16740	COG2983	Belongs to the UPF0260 family
H0S57_16745	COG5487	UPF0391 membrane protein
H0S57_16775	COG2818	Glycosylase
H0S57_16780	COG1064	alcohol dehydrogenase
H0S57_16785	COG0436	Aminotransferase
H0S57_16800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0S57_16830	COG1309	transcriptional regulator
H0S57_16840	COG2233	PERMEase
H0S57_16845	COG0583	DNA-binding transcription factor activity
H0S57_16855	COG4774	siderophore transport
H0S57_16865	COG0129	dihydroxy-acid dehydratase activity
H0S57_16885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0S57_16885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H0S57_16915	COG0733	neurotransmitter:sodium symporter activity
H0S57_16925	COG2814	Major facilitator Superfamily
H0S57_16955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S57_16960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H0S57_16965	COG2951	lytic endotransglycosylase activity
H0S57_16970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H0S57_16985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S57_17005	COG0861	Integral membrane protein TerC family
H0S57_17015	COG0754	glutathionylspermidine amidase activity
H0S57_17025	COG0402	S-adenosylhomocysteine deaminase activity
H0S57_17045	COG1230	cation diffusion facilitator family transporter
H0S57_17060	COG0583	DNA-binding transcription factor activity
H0S57_17075	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H0S57_17080	COG0281	malic enzyme
H0S57_17090	COG0706	membrane insertase activity
H0S57_17095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane