locus-tag	class	description
I6I49_00145	COG2801	Transposase and inactivated derivatives
I6I49_00155	COG3077	Addiction module antitoxin, RelB DinJ family
I6I49_00160	COG2801	Transposase and inactivated derivatives
I6I49_00200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I49_00205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I49_00210	COG1116	anion transmembrane transporter activity
I6I49_00215	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6I49_00245	COG0753	catalase activity
I6I49_00255	COG4372	Transposase
I6I49_00275	COG3657	addiction module killer protein
I6I49_00280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I49_00285	COG1335	isochorismatase
I6I49_00315	COG0210	DNA helicase
I6I49_00380	COG0515	serine threonine protein kinase
I6I49_00385	COG2116	formate transmembrane transporter activity
I6I49_00390	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I49_00485	COG1192	Involved in chromosome partitioning
I6I49_00535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I49_00555	COG2814	Major facilitator Superfamily
I6I49_00665	COG2217	Heavy metal translocating P-type atpase
I6I49_00670	COG3174	membrane
I6I49_00675	COG2205	protein histidine kinase activity
I6I49_00695	COG2132	Multicopper oxidase
I6I49_00720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I49_00795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I49_00815	COG2369	cell adhesion
I6I49_00825	COG0582	viral genome integration into host DNA
I6I49_00850	COG0830	nickel cation binding
I6I49_00865	COG0829	nickel cation binding
I6I49_00870	COG0831	urea catabolic process
I6I49_00885	COG0804	urea catabolic process
I6I49_00900	COG2351	hydroxyisourate hydrolase activity
I6I49_00905	COG2233	PERMEase
I6I49_00920	COG4266	Belongs to the allantoicase family
I6I49_00925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I49_00930	COG0583	DNA-binding transcription factor activity
I6I49_00945	COG2233	PERMEase
I6I49_01135	COG2801	Transposase and inactivated derivatives
I6I49_01140	COG2801	Transposase and inactivated derivatives
I6I49_01290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I49_01310	COG0604	alcohol dehydrogenase
I6I49_01340	COG1063	alcohol dehydrogenase
I6I49_01350	COG1373	ATPase (AAA superfamily
I6I49_01370	COG2801	Transposase and inactivated derivatives
I6I49_01375	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I6I49_01390	COG2814	Major facilitator Superfamily
I6I49_01435	COG4680	protein conserved in bacteria
I6I49_01465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I49_01470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I49_01500	COG4680	protein conserved in bacteria
I6I49_01520	COG1063	alcohol dehydrogenase
I6I49_01540	COG2323	membrane
I6I49_01585	COG2223	nitrite transmembrane transporter activity
I6I49_01590	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I49_01595	COG1877	trehalose-phosphatase activity
I6I49_01600	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_01620	COG1570	exodeoxyribonuclease VII activity
I6I49_01650	COG0582	viral genome integration into host DNA
I6I49_01715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I49_01720	COG0004	ammonium transporteR
I6I49_01735	COG1064	alcohol dehydrogenase
I6I49_01750	COG2801	Transposase and inactivated derivatives
I6I49_01830	COG0693	protein deglycase activity
I6I49_01835	COG1960	acyl-CoA dehydrogenase activity
I6I49_01845	COG1301	dicarboxylic acid transport
I6I49_01850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I49_01860	COG3139	Protein of unknown function (DUF1315)
I6I49_01865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I49_01870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I49_01880	COG0494	nUDIX hydrolase
I6I49_01890	COG0642	Histidine kinase
I6I49_01910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I49_01920	COG1720	tRNA m6t6A37 methyltransferase activity
I6I49_01955	COG0826	peptidase U32
I6I49_01960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I49_01970	COG3634	alkyl hydroperoxide reductase activity
I6I49_01990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I49_02045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I49_02050	COG4149	molybdate abc transporter
I6I49_02055	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I49_02065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I49_02070	COG0243	molybdopterin cofactor binding
I6I49_02075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I49_02080	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I49_02080	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I49_02085	COG0303	'Molybdopterin
I6I49_02105	COG2365	Tyrosine phosphatase family
I6I49_02115	COG1131	(ABC) transporter
I6I49_02120	COG0842	Transport permease protein
I6I49_02135	COG2951	lytic endotransglycosylase activity
I6I49_02170	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I49_02190	COG2175	clavaminate synthase activity
I6I49_02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I49_02210	COG0842	Transport permease protein
I6I49_02245	COG1280	lysine exporter protein (LysE YggA)
I6I49_02250	COG1522	sequence-specific DNA binding
I6I49_02255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I49_02265	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I49_02275	COG0019	diaminopimelate decarboxylase activity
I6I49_02285	COG1113	amino acid transport
I6I49_02290	COG1115	amino acid carrier protein
I6I49_02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I49_02310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I49_02315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I49_02320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I49_02325	COG3385	transposase activity
I6I49_02370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I49_02375	COG3161	chorismate lyase activity
I6I49_02385	COG0174	glutamine synthetase
I6I49_02390	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I49_02395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I49_02400	COG0134	indole-3-glycerol-phosphate synthase activity
I6I49_02420	COG0302	gtp cyclohydrolase
I6I49_02445	COG3739	integral membrane protein
I6I49_02465	COG1741	Belongs to the pirin family
I6I49_02480	COG1309	transcriptional regulator
I6I49_02510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I49_02515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I49_02525	COG0037	tRNA processing
I6I49_02530	COG0741	lytic transglycosylase activity
I6I49_02535	COG0501	Belongs to the peptidase M48B family
I6I49_02550	COG2239	Acts as a magnesium transporter
I6I49_02580	COG1253	flavin adenine dinucleotide binding
I6I49_02585	COG2851	Citrate transporter
I6I49_02625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I49_02630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I49_02655	COG0505	Belongs to the CarA family
I6I49_02660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I49_02670	COG0110	maltose O-acetyltransferase activity
I6I49_02705	COG2321	neutral zinc metallopeptidase
I6I49_02710	COG2354	Protein conserved in bacteria
I6I49_02720	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I49_02725	COG2268	Band 7 protein
I6I49_02735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I49_02745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I49_02760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I49_02765	COG1053	succinate dehydrogenase
I6I49_02770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I49_02775	COG2009	succinate dehydrogenase
I6I49_02785	COG2072	flavoprotein involved in K transport
I6I49_02790	COG0300	oxidoreductase activity
I6I49_02805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I49_02805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I49_02830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I49_02855	COG0564	pseudouridine synthase activity
I6I49_02865	COG0358	DNA primase activity
I6I49_02880	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I49_02910	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I49_02915	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I49_02980	COG0586	Pfam SNARE associated Golgi protein
I6I49_03020	COG2921	Belongs to the UPF0250 family
I6I49_03025	COG0321	lipoyl(octanoyl) transferase activity
I6I49_03040	COG0531	amino acid
I6I49_03060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I49_03065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I49_03065	COG1648	precorrin-2 dehydrogenase activity
I6I49_03070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I49_03080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I49_03090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I49_03110	COG0671	phosphoesterase, PA-phosphatase related
I6I49_03115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I49_03125	COG1538	Outer membrane efflux protein
I6I49_03130	COG0393	Putative heavy-metal-binding
I6I49_03145	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_03155	COG0525	valine-tRNA ligase activity
I6I49_03185	COG0583	DNA-binding transcription factor activity
I6I49_03195	COG1278	Cold shock
I6I49_03210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I49_03215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I49_03220	COG0713	ATP synthesis coupled electron transport
I6I49_03230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I49_03245	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I49_03265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I49_03275	COG2205	protein histidine kinase activity
I6I49_03280	COG0745	RESPONSE REGULATOR receiver
I6I49_03285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I49_03285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I49_03295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I49_03335	COG3209	COG3209 Rhs family protein
I6I49_03375	COG0439	Biotin carboxylase
I6I49_03380	COG1802	Transcriptional regulator
I6I49_03385	COG1652	LysM domain
I6I49_03395	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_03415	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I49_03420	COG3101	peptidyl-lysine hydroxylation
I6I49_03425	COG0009	L-threonylcarbamoyladenylate synthase
I6I49_03435	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I49_03440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I49_03480	COG4106	trans-aconitate 2-methyltransferase activity
I6I49_03495	COG2267	carboxylic ester hydrolase activity
I6I49_03500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I49_03505	COG2193	ferroxidase activity
I6I49_03530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I49_03535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I49_03540	COG3115	cell septum assembly
I6I49_03545	COG1196	nuclear chromosome segregation
I6I49_03555	COG0730	response to heat
I6I49_03575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I49_03590	COG0488	(ABC) transporter
I6I49_03615	COG3422	double-strand break repair
I6I49_03630	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I49_03635	COG3189	MarR family transcriptional regulator
I6I49_03655	COG0564	pseudouridine synthase activity
I6I49_03660	COG0346	lactoylglutathione lyase activity
I6I49_03700	COG1487	ribonuclease activity
I6I49_03705	COG4456	Virulence-associated protein
I6I49_03735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I49_03765	COG1902	pentaerythritol trinitrate reductase activity
I6I49_03770	COG3659	wide pore channel activity
I6I49_03780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I49_03795	COG1970	mechanosensitive ion channel activity
I6I49_03800	COG1217	gtp-binding protein TYPA
I6I49_03805	COG2233	PERMEase
I6I49_03810	COG2813	Specifically methylates the guanine in position
I6I49_03815	COG0833	amino acid
I6I49_03830	COG0183	Belongs to the thiolase family
I6I49_03850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I49_03865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I49_03870	COG2207	Transcriptional regulator
I6I49_03875	COG0183	Belongs to the thiolase family
I6I49_03880	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I49_03880	COG1024	Enoyl-CoA hydratase
I6I49_03900	COG1272	protein, Hemolysin III
I6I49_03905	COG0477	Major facilitator Superfamily
I6I49_03915	COG1408	metallophosphoesterase
I6I49_03920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I49_03930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I49_03955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I49_03960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I49_03985	COG3335	DDE superfamily endonuclease
I6I49_04035	COG1484	DNA-dependent DNA replication
I6I49_04040	COG4584	PFAM Integrase catalytic
I6I49_04085	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6I49_04145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I49_04150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I49_04160	COG0625	glutathione transferase activity
I6I49_04165	COG2969	positive regulation of protein catabolic process
I6I49_04245	COG3335	DDE superfamily endonuclease
I6I49_04275	COG3335	DDE superfamily endonuclease
I6I49_04310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I49_04315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I49_04390	COG0450	alkyl hydroperoxide reductase
I6I49_04410	COG0285	dihydrofolate synthase activity
I6I49_04435	COG3293	Transposase
I6I49_04440	COG3335	DDE superfamily endonuclease
I6I49_04475	COG4206	TonB-dependent receptor
I6I49_04480	COG2096	Adenosyltransferase
I6I49_04500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I49_04505	COG2315	Protein conserved in bacteria
I6I49_04515	COG1113	amino acid transport
I6I49_04520	COG0745	RESPONSE REGULATOR receiver
I6I49_04525	COG2205	protein histidine kinase activity
I6I49_04540	COG1960	acyl-CoA dehydrogenase activity
I6I49_04545	COG1960	acyl-CoA dehydrogenase activity
I6I49_04550	COG3223	Belongs to the PsiE family
I6I49_04580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I49_04610	COG3306	glycosyltransferase involved in LPS biosynthesis
I6I49_04640	COG0438	transferase activity, transferring glycosyl groups
I6I49_04660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I49_04665	COG5002	protein histidine kinase activity
I6I49_04675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I49_04720	COG1862	Preprotein translocase
I6I49_04745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I49_04765	COG1426	Protein conserved in bacteria
I6I49_04845	COG0440	acetolactate synthase activity
I6I49_04850	COG0028	Belongs to the TPP enzyme family
I6I49_04875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I49_04880	COG0577	efflux transmembrane transporter activity
I6I49_04880	COG1136	(ABC) transporter
I6I49_04885	COG1538	Outer membrane efflux protein
I6I49_04900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I49_04905	COG1162	GTPase activity
I6I49_04930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I49_04935	COG2003	Belongs to the UPF0758 family
I6I49_04940	COG3781	membrane
I6I49_04945	COG0613	PHP domain protein
I6I49_04955	COG2350	Protein conserved in bacteria
I6I49_04975	COG1666	GTP binding
I6I49_04990	COG1607	acyl-coa hydrolase
I6I49_05025	COG3293	Transposase
I6I49_05060	COG1183	phosphatidylcholine synthase activity
I6I49_05065	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I49_05090	COG0039	L-malate dehydrogenase activity
I6I49_05100	COG0741	lytic transglycosylase activity
I6I49_05100	COG1196	nuclear chromosome segregation
I6I49_05100	COG0739	heme binding
I6I49_05105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I49_05110	COG1702	phosphate starvation-inducible protein PhoH
I6I49_05115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I49_05140	COG3293	Transposase
I6I49_05165	COG1295	ribonuclease BN
I6I49_05180	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I49_05215	COG0557	exoribonuclease II activity
I6I49_05220	COG2720	vancomycin resistance protein
I6I49_05225	COG0339	signal peptide processing
I6I49_05230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I49_05265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I49_05270	COG1960	acyl-CoA dehydrogenase activity
I6I49_05280	COG2072	flavoprotein involved in K transport
I6I49_05285	COG0203	ribosomal protein L17
I6I49_05290	COG0202	RNA polymerase activity
I6I49_05305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I49_05330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I49_05340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I49_05345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I49_05395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I49_05410	COG0088	Forms part of the polypeptide exit tunnel
I6I49_05415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I49_05435	COG0433	COG0433 Predicted ATPase
I6I49_05445	COG1959	2 iron, 2 sulfur cluster binding
I6I49_05465	COG1301	dicarboxylic acid transport
I6I49_05470	COG1946	Acyl-CoA thioesterase
I6I49_05475	COG2937	Belongs to the GPAT DAPAT family
I6I49_05520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I49_05525	COG1040	competence protein
I6I49_05530	COG0494	nUDIX hydrolase
I6I49_05540	COG0598	Magnesium transport protein CorA
I6I49_05550	COG2854	intermembrane phospholipid transfer
I6I49_05555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I49_05560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I49_05565	COG1127	ABC transporter
I6I49_05570	COG0513	Belongs to the DEAD box helicase family
I6I49_05595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I49_05600	COG0408	coproporphyrinogen oxidase activity
I6I49_05620	COG1960	acyl-CoA dehydrogenase activity
I6I49_05645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I49_05655	COG0534	Mate efflux family protein
I6I49_05665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I49_05670	COG0254	rRNA binding
I6I49_05675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I49_05680	COG2963	transposase activity
I6I49_05715	COG2226	methyltransferase
I6I49_05725	COG1192	Involved in chromosome partitioning
I6I49_05730	COG0628	permease
I6I49_05735	COG2032	superoxide dismutase activity
I6I49_05740	COG1289	transmembrane transporter activity
I6I49_05745	COG2814	Major facilitator Superfamily
I6I49_05770	COG0277	FAD linked oxidase domain protein
I6I49_05775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I49_05780	COG5006	permease, DMT superfamily
I6I49_05785	COG5006	permease, DMT superfamily
I6I49_05800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I49_05805	COG5380	lipid catabolic process
I6I49_05835	COG0335	large ribosomal subunit rRNA binding
I6I49_05845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I49_05850	COG0228	four-way junction DNA binding
I6I49_05865	COG0194	GDP metabolic process
I6I49_05870	COG1758	RNA polymerase activity
I6I49_05875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I49_05910	COG4372	Transposase
I6I49_05930	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I49_05935	COG1704	LemA family
I6I49_05960	COG0493	'glutamate synthase
I6I49_05965	COG0067	glutamate synthase
I6I49_05965	COG0069	glutamate synthase activity
I6I49_05965	COG0070	glutamate synthase
I6I49_06015	COG2226	methyltransferase
I6I49_06025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I49_06030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I49_06050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I49_06065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I49_06085	COG0488	(ABC) transporter
I6I49_06090	COG2873	o-acetylhomoserine
I6I49_06095	COG4221	oxidoreductase activity
I6I49_06115	COG3385	transposase activity
I6I49_06135	COG0427	acetyl-CoA hydrolase
I6I49_06170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I49_06215	COG1278	Cold shock
I6I49_06220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I49_06250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I49_06280	COG3158	transport of potassium into the cell
I6I49_06290	COG0582	viral genome integration into host DNA
I6I49_06470	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6I49_06480	COG1335	isochorismatase
I6I49_06495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I49_06510	COG1301	dicarboxylic acid transport
I6I49_06515	COG0583	DNA-binding transcription factor activity
I6I49_06525	COG0629	single-stranded DNA binding
I6I49_06530	COG2814	Major facilitator Superfamily
I6I49_06540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I49_06540	COG0352	thiamine-phosphate diphosphorylase activity
I6I49_06540	COG0351	phosphomethylpyrimidine kinase
I6I49_06570	COG3293	Transposase
I6I49_06575	COG3706	GGDEF domain
I6I49_06585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I49_06600	COG3162	membrane
I6I49_06605	COG0784	Response regulator, receiver
I6I49_06605	COG2205	protein histidine kinase activity
I6I49_06620	COG3293	Transposase
I6I49_06625	COG0431	NADPH-dependent FMN reductase
I6I49_06640	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_06645	COG0307	riboflavin synthase, alpha
I6I49_06650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I49_06655	COG0668	transmembrane transport
I6I49_06660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I49_06665	COG1519	Transferase
I6I49_06670	COG1902	pentaerythritol trinitrate reductase activity
I6I49_06700	COG3385	transposase activity
I6I49_06705	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I49_06730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I49_06730	COG0426	domain, Protein
I6I49_06735	COG2119	membrane
I6I49_06765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I49_06775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I49_06785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I49_06800	COG0189	ligase activity
I6I49_06805	COG0386	Belongs to the glutathione peroxidase family
I6I49_06810	COG1846	Transcriptional regulator
I6I49_06820	COG3335	DDE superfamily endonuclease
I6I49_06845	COG0708	Exodeoxyribonuclease III
I6I49_06850	COG1393	Belongs to the ArsC family
I6I49_06865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I49_06870	COG3706	GGDEF domain
I6I49_06895	COG3385	transposase activity
I6I49_06925	COG3385	transposase activity
I6I49_06965	COG3150	esterase
I6I49_06975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I49_06980	COG2918	glutathione biosynthetic process
I6I49_06995	COG2733	membrane
I6I49_07000	COG0436	Aminotransferase
I6I49_07005	COG0534	Mate efflux family protein
I6I49_07080	COG0385	Bile acid
I6I49_07085	COG1335	isochorismatase
I6I49_07090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I49_07110	COG4215	(ABC) transporter
I6I49_07115	COG4160	amino acid transport
I6I49_07135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I49_07140	COG2983	Belongs to the UPF0260 family
I6I49_07145	COG5487	UPF0391 membrane protein
I6I49_07175	COG2818	Glycosylase
I6I49_07180	COG1064	alcohol dehydrogenase
I6I49_07185	COG0436	Aminotransferase
I6I49_07200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I49_07230	COG1309	transcriptional regulator
I6I49_07240	COG2233	PERMEase
I6I49_07245	COG0583	DNA-binding transcription factor activity
I6I49_07275	COG0129	dihydroxy-acid dehydratase activity
I6I49_07325	COG0733	neurotransmitter:sodium symporter activity
I6I49_07330	COG1012	belongs to the aldehyde dehydrogenase family
I6I49_07375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I49_07385	COG0657	acetylesterase activity
I6I49_07425	COG3385	transposase activity
I6I49_07460	COG0488	(ABC) transporter
I6I49_07470	COG3385	transposase activity
I6I49_07475	COG0187	DNA topoisomerase II activity
I6I49_07485	COG0592	DNA-directed DNA polymerase activity
I6I49_07490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I49_07505	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I49_07510	COG0706	membrane insertase activity
I6I49_07530	COG1230	cation diffusion facilitator family transporter
I6I49_07550	COG0402	S-adenosylhomocysteine deaminase activity
I6I49_07565	COG0754	glutathionylspermidine amidase activity
I6I49_07575	COG0861	Integral membrane protein TerC family
I6I49_07630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I49_07645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I49_07660	COG2951	lytic endotransglycosylase activity
I6I49_07665	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I49_07670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I49_07700	COG2133	pyrroloquinoline quinone binding
I6I49_07715	COG1047	Peptidyl-prolyl cis-trans
I6I49_07720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I49_07725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I49_07730	COG0196	riboflavin kinase activity
I6I49_07745	COG1309	transcriptional regulator
I6I49_07750	COG1116	anion transmembrane transporter activity
I6I49_07755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I49_07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I49_07765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I49_07770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I49_07775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I49_07775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I49_07810	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_07815	COG0546	phosphoglycolate phosphatase activity
I6I49_07820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I49_07825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I49_07830	COG3307	-O-antigen
I6I49_07840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I49_07850	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I49_07855	COG0728	peptidoglycan biosynthetic process
I6I49_07885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I49_07915	COG0438	transferase activity, transferring glycosyl groups
I6I49_07920	COG0438	transferase activity, transferring glycosyl groups
I6I49_07925	COG0438	transferase activity, transferring glycosyl groups
I6I49_07930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I49_07935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I49_07945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I49_07955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I49_07970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I49_07975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I49_07980	COG1215	transferase activity, transferring glycosyl groups
I6I49_08020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I49_08035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I49_08085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I49_08095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I49_08100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I49_08110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I49_08125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I49_08130	COG0583	DNA-binding transcription factor activity
I6I49_08135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I49_08135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I49_08140	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I49_08145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I49_08145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I49_08145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I49_08155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I49_08160	COG3550	peptidyl-serine autophosphorylation
I6I49_08175	COG2197	response regulator
I6I49_08210	COG2963	transposase activity
I6I49_08300	COG0494	nUDIX hydrolase
I6I49_08335	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_08350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I49_08355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I49_08360	COG3138	arginine N-succinyltransferase
I6I49_08365	COG1012	belongs to the aldehyde dehydrogenase family
I6I49_08370	COG3724	N-succinylarginine dihydrolase activity
I6I49_08380	COG1113	amino acid transport
I6I49_08385	COG3335	DDE superfamily endonuclease
I6I49_08410	COG3756	Protein conserved in bacteria
I6I49_08460	COG0271	Belongs to the BolA IbaG family
I6I49_08470	COG1192	Involved in chromosome partitioning
I6I49_08485	COG0586	Pfam SNARE associated Golgi protein
I6I49_08500	COG0519	Catalyzes the synthesis of GMP from XMP
I6I49_08500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I49_08515	COG4372	Transposase
I6I49_08570	COG0281	malic enzyme
I6I49_08585	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_08600	COG2837	iron assimilation
I6I49_08615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I49_08620	COG1121	(ABC) transporter
I6I49_08670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I49_08700	COG0386	Belongs to the glutathione peroxidase family
I6I49_08710	COG0697	spore germination
I6I49_08720	COG0758	DNA mediated transformation
I6I49_08800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I49_08810	COG2814	Major facilitator Superfamily
I6I49_08830	COG4372	Transposase
I6I49_08845	COG1253	flavin adenine dinucleotide binding
I6I49_08850	COG3012	SEC-C Motif Domain Protein
I6I49_08855	COG2860	membrane
I6I49_08860	COG0477	Major facilitator Superfamily
I6I49_08870	COG0318	PFAM AMP-dependent synthetase and ligase
I6I49_08890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I49_08930	COG0347	Belongs to the P(II) protein family
I6I49_08935	COG0004	ammonium transporteR
I6I49_08945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I49_08945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I49_08960	COG0586	Pfam SNARE associated Golgi protein
I6I49_08980	COG0795	lipopolysaccharide-transporting ATPase activity
I6I49_08985	COG0795	lipopolysaccharide-transporting ATPase activity
I6I49_08990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I49_08995	COG0793	Belongs to the peptidase S41A family
I6I49_09020	COG2197	response regulator
I6I49_09025	COG1686	Belongs to the peptidase S11 family
I6I49_09030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I49_09040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I49_09045	COG4974	Belongs to the 'phage' integrase family
I6I49_09065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I49_09070	COG0772	Belongs to the SEDS family
I6I49_09075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I49_09080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I49_09085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I49_09095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I49_09105	COG1538	Outer membrane efflux protein
I6I49_09135	COG0181	hydroxymethylbilane synthase activity
I6I49_09200	COG0546	phosphoglycolate phosphatase activity
I6I49_09230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I49_09250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I49_09255	COG0081	regulation of translation
I6I49_09260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I49_09265	COG0222	ribosome binding
I6I49_09270	COG0085	RNA polymerase activity
I6I49_09275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I49_09280	COG4372	Transposase
I6I49_09315	COG2056	Na+-H+ antiporter family
I6I49_09330	COG3047	cAMP biosynthetic process
I6I49_09340	COG0326	Molecular chaperone. Has ATPase activity
I6I49_09370	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I49_09395	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_09440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I49_09445	COG1132	(ABC) transporter
I6I49_09460	COG1289	transmembrane transporter activity
I6I49_09475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I49_09480	COG1678	Uncharacterized ACR, COG1678
I6I49_09485	COG0497	DNA recombination
I6I49_09495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I49_09505	COG0237	dephospho-CoA kinase activity
I6I49_09565	COG0195	Participates in both transcription termination and antitermination
I6I49_09570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I49_09575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I49_09580	COG3335	DDE superfamily endonuclease
I6I49_09590	COG1320	monovalent cation:proton antiporter activity
I6I49_09595	COG2212	antiporter activity
I6I49_09600	COG1863	multisubunit Na H antiporter MnhE subunit
I6I49_09605	COG0651	ATP synthesis coupled electron transport
I6I49_09610	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I49_09615	COG2111	Na H antiporter
I6I49_09615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I49_09620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I49_09630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I49_09650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I49_09680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I49_09685	COG1074	ATP-dependent DNA helicase activity
I6I49_09690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I49_09695	COG4372	Transposase
I6I49_09710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I49_09720	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I49_09725	COG0598	Magnesium transport protein CorA
I6I49_09730	COG2841	Protein conserved in bacteria
I6I49_09750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I49_09760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I49_09780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I49_09785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I49_09790	COG4535	Mg2 and Co2 transporter CorC
I6I49_09795	COG0425	Belongs to the sulfur carrier protein TusA family
I6I49_09805	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I49_09805	COG0644	oxidoreductase
I6I49_09815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I49_09825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I49_09830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I49_09840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I49_09850	COG0493	'glutamate synthase
I6I49_09850	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I49_09885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I49_09915	COG0751	glycine-tRNA ligase activity
I6I49_09935	COG1983	PspC domain protein
I6I49_09965	COG0318	PFAM AMP-dependent synthetase and ligase
I6I49_09970	COG1530	ribonuclease E activity
I6I49_09975	COG0564	pseudouridine synthase activity
I6I49_09990	COG0583	DNA-binding transcription factor activity
I6I49_09995	COG3293	Transposase
I6I49_10015	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6I49_10040	COG1960	acyl-CoA dehydrogenase activity
I6I49_10055	COG1280	lysine exporter protein (LysE YggA)
I6I49_10090	COG0583	DNA-binding transcription factor activity
I6I49_10100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I49_10115	COG0473	3-isopropylmalate dehydrogenase activity
I6I49_10130	COG0675	Transposase, IS605 OrfB family
I6I49_10185	COG1560	Kdo2-lipid A biosynthetic process
I6I49_10195	COG0488	(ABC) transporter
I6I49_10200	COG2900	Belongs to the SlyX family
I6I49_10245	COG1929	Belongs to the glycerate kinase type-1 family
I6I49_10250	COG0210	DNA helicase
I6I49_10275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I49_10275	COG4651	solute:proton antiporter activity
I6I49_10300	COG0788	formyltetrahydrofolate deformylase activity
I6I49_10405	COG2813	Specifically methylates the guanine in position
I6I49_10405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I49_10410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I49_10425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I49_10440	COG4774	siderophore transport
I6I49_10445	COG4771	TonB-dependent receptor
I6I49_10455	COG0740	serine-type endopeptidase activity
I6I49_10475	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I49_10475	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I49_10480	COG1917	Cupin 2, conserved barrel domain protein
I6I49_10480	COG2207	Transcriptional regulator
I6I49_10485	COG0697	spore germination
I6I49_10505	COG0857	belongs to the CobB CobQ family
I6I49_10505	COG0280	phosphate acetyltransferase
I6I49_10510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I49_10515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I49_10520	COG2267	carboxylic ester hydrolase activity
I6I49_10535	COG0793	Belongs to the peptidase S41A family
I6I49_10545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I49_10560	COG0084	hydrolase, TatD family'
I6I49_10570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I49_10595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I49_10625	COG0659	secondary active sulfate transmembrane transporter activity
I6I49_10635	COG4772	TonB-dependent receptor
I6I49_10680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I49_10715	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I49_10745	COG2814	Major facilitator Superfamily
I6I49_10770	COG0004	ammonium transporteR
I6I49_10785	COG3622	Belongs to the hyi family
I6I49_10790	COG2084	Dehydrogenase
I6I49_10795	COG1024	Enoyl-CoA hydratase
I6I49_10800	COG0784	Response regulator, receiver
I6I49_10800	COG2205	protein histidine kinase activity
I6I49_10800	COG5002	protein histidine kinase activity
I6I49_10805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I49_10820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I49_10835	COG3956	TIGRFAM MazG family protein
I6I49_10840	COG1555	photosystem II stabilization
I6I49_10845	COG0617	tRNA 3'-terminal CCA addition
I6I49_10850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I49_10860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I49_10865	COG1660	Displays ATPase and GTPase activities
I6I49_10875	COG3028	Belongs to the UPF0307 family
I6I49_10880	COG0318	PFAM AMP-dependent synthetase and ligase
I6I49_10900	COG0625	glutathione transferase activity
I6I49_10910	COG1238	metal cluster binding
I6I49_10970	COG0072	phenylalanine-tRNA ligase activity
I6I49_10995	COG0248	Ppx GppA phosphatase
I6I49_11005	COG0037	tRNA processing
I6I49_11020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I49_11020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I49_11050	COG1764	response to oxidative stress
I6I49_11055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I49_11065	COG2208	phosphoserine phosphatase activity
I6I49_11070	COG2853	Lipoprotein
I6I49_11100	COG2814	Major facilitator Superfamily
I6I49_11110	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_11120	COG0693	protein deglycase activity
I6I49_11145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I49_11155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I49_11195	COG0675	Transposase, IS605 OrfB family
I6I49_11200	COG3385	transposase activity
I6I49_11210	COG0494	nUDIX hydrolase
I6I49_11215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I49_11220	COG1214	PFAM Peptidase M22, glycoprotease
I6I49_11225	COG1968	undecaprenyl-diphosphatase activity
I6I49_11285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I49_11300	COG2132	Multicopper oxidase
I6I49_11325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I49_11335	COG0351	phosphomethylpyrimidine kinase
I6I49_11335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I49_11335	COG0352	thiamine-phosphate diphosphorylase activity
I6I49_11365	COG0251	oxidation-reduction process
I6I49_11370	COG1113	amino acid transport
I6I49_11385	COG1981	membrane
I6I49_11400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I49_11415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I49_11445	COG0675	Transposase, IS605 OrfB family
I6I49_11455	COG0456	acetyltransferase
I6I49_11465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I49_11470	COG0492	ferredoxin-NADP+ reductase activity
I6I49_11475	COG0531	amino acid
I6I49_11475	COG1674	ftsk spoiiie
I6I49_11490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I49_11495	COG2894	cell division
I6I49_11500	COG0850	regulation of cytokinetic process
I6I49_11510	COG0204	Acyl-transferase
I6I49_11515	COG2885	chlorophyll binding
I6I49_11520	COG0210	DNA helicase
I6I49_11525	COG0756	dUTP diphosphatase activity
I6I49_11540	COG0121	glutamine amidotransferase
I6I49_11575	COG2914	Belongs to the UPF0125 (RnfH) family
I6I49_11580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I49_11585	COG0735	belongs to the Fur family
I6I49_11615	COG0420	3'-5' exonuclease activity
I6I49_11620	COG3706	GGDEF domain
I6I49_11620	COG2203	Gaf domain
I6I49_11620	COG5001	Diguanylate cyclase
I6I49_11620	COG4251	negative regulation of phosphorylation
I6I49_11645	COG2050	protein possibly involved in aromatic compounds catabolism
I6I49_11655	COG1566	PFAM secretion protein HlyD family protein
I6I49_11660	COG2814	Major facilitator Superfamily
I6I49_11665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I49_11675	COG0582	viral genome integration into host DNA
I6I49_11950	COG0582	viral genome integration into host DNA
I6I49_11955	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_11965	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6I49_11970	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_12015	COG2184	nucleotidyltransferase activity
I6I49_12055	COG0443	Heat shock 70 kDa protein
I6I49_12060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I49_12080	COG3177	Filamentation induced by cAMP protein fic
I6I49_12130	COG0629	single-stranded DNA binding
I6I49_12175	COG4221	oxidoreductase activity
I6I49_12180	COG0583	DNA-binding transcription factor activity
I6I49_12185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I49_12190	COG0604	alcohol dehydrogenase
I6I49_12190	COG3321	synthase
I6I49_12235	COG1979	alcohol dehydrogenase
I6I49_12245	COG1902	pentaerythritol trinitrate reductase activity
I6I49_12255	COG1309	transcriptional regulator
I6I49_12260	COG2130	NADP-dependent
I6I49_12295	COG1802	Transcriptional regulator
I6I49_12355	COG3188	usher protein
I6I49_12370	COG0737	Belongs to the 5'-nucleotidase family
I6I49_12380	COG2814	Major facilitator Superfamily
I6I49_12385	COG0583	DNA-binding transcription factor activity
I6I49_12395	COG1522	sequence-specific DNA binding
I6I49_12405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I49_12425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I49_12435	COG1294	oxidase, subunit
I6I49_12465	COG4772	TonB-dependent receptor
I6I49_12475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I49_12495	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I49_12535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I49_12545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I49_12550	COG1077	Cell shape determining protein MreB Mrl
I6I49_12555	COG1792	Involved in formation and maintenance of cell shape
I6I49_12560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I49_12565	COG0424	maF-like protein
I6I49_12580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I49_12640	COG0640	Transcriptional regulator
I6I49_12650	COG0798	PFAM Bile acid sodium symporter
I6I49_12655	COG0431	NADPH-dependent FMN reductase
I6I49_12660	COG2072	flavoprotein involved in K transport
I6I49_12670	COG0625	glutathione transferase activity
I6I49_12690	COG1113	amino acid transport
I6I49_12715	COG1113	amino acid transport
I6I49_12720	COG2828	Protein conserved in bacteria
I6I49_12725	COG0142	geranyltranstransferase activity
I6I49_12740	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I49_12765	COG0745	RESPONSE REGULATOR receiver
I6I49_12770	COG0642	Histidine kinase
I6I49_12780	COG0546	phosphoglycolate phosphatase activity
I6I49_12785	COG0004	ammonium transporteR
I6I49_12805	COG1126	abc transporter atp-binding protein
I6I49_12810	COG0765	amino acid transport
I6I49_12815	COG0765	amino acid transport
I6I49_12835	COG0668	transmembrane transport
I6I49_12850	COG2081	HI0933 family
I6I49_12855	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I49_12890	COG4716	Myosin-crossreactive antigen
I6I49_12915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I49_12935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I49_12935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I49_12955	COG0489	protein tyrosine kinase activity
I6I49_12970	COG2358	TRAP transporter, solute receptor (TAXI family
I6I49_13015	COG1566	PFAM secretion protein HlyD family protein
I6I49_13055	COG0643	Histidine kinase
I6I49_13055	COG0784	Response regulator, receiver
I6I49_13055	COG2198	Histidine kinase
I6I49_13065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I49_13085	COG2832	Protein of unknown function (DUF454)
I6I49_13160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I49_13170	COG1289	transmembrane transporter activity
I6I49_13190	COG2814	Major facilitator Superfamily
I6I49_13205	COG0786	glutamate:sodium symporter activity
I6I49_13210	COG1115	amino acid carrier protein
I6I49_13220	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I49_13225	COG1607	acyl-coa hydrolase
I6I49_13235	COG0523	cobalamin synthesis protein
I6I49_13240	COG4681	YaeQ
I6I49_13250	COG2199	diguanylate cyclase activity
I6I49_13250	COG2203	Gaf domain
I6I49_13300	COG0242	peptide deformylase activity
I6I49_13310	COG2223	nitrite transmembrane transporter activity
I6I49_13320	COG2852	Protein conserved in bacteria
I6I49_13335	COG0306	phosphate transporter
I6I49_13380	COG4181	ATPase activity
I6I49_13385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I49_13405	COG0583	DNA-binding transcription factor activity
I6I49_13415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I49_13420	COG1773	rubredoxin
I6I49_13425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I49_13480	COG1695	Transcriptional regulator
I6I49_13495	COG3321	synthase
I6I49_13495	COG4221	oxidoreductase activity
I6I49_13495	COG0604	alcohol dehydrogenase
I6I49_13495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I49_13520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I49_13540	COG0477	Major facilitator Superfamily
I6I49_13555	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I49_13565	COG1597	lipid kinase activity
I6I49_13585	COG0641	radical SAM
I6I49_13590	COG3119	arylsulfatase activity
I6I49_13615	COG0742	ribosomal rna small subunit methyltransferase
I6I49_13620	COG0768	penicillin binding
I6I49_13645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I49_13650	COG2878	Part of a membrane complex involved in electron transport
I6I49_13655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I49_13665	COG3384	dioxygenase
I6I49_13675	COG2234	aminopeptidase activity
I6I49_13690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I49_13700	COG2217	Heavy metal translocating P-type atpase
I6I49_13710	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I49_13730	COG4770	biotin carboxylase activity
I6I49_13755	COG0006	proline dipeptidase activity
I6I49_13780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I49_13785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I49_13805	COG2915	High frequency lysogenization protein hflD homolog
I6I49_13825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I49_13830	COG1686	Belongs to the peptidase S11 family
I6I49_13845	COG0789	Transcriptional regulator
I6I49_13880	COG2826	transposase and inactivated derivatives, IS30 family
I6I49_13905	COG1388	LysM domain
I6I49_13905	COG4942	peptidase
I6I49_13910	COG0583	DNA-binding transcription factor activity
I6I49_13930	COG0657	acetylesterase activity
I6I49_13935	COG2816	NAD+ diphosphatase activity
I6I49_13945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I49_13950	COG0741	lytic transglycosylase activity
I6I49_13950	COG1388	LysM domain
I6I49_13955	COG4166	transmembrane transport
I6I49_13960	COG4174	ABC transporter (Permease)
I6I49_13965	COG4239	(ABC) transporter, permease
I6I49_13970	COG4172	Belongs to the ABC transporter superfamily
I6I49_13985	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I49_14010	COG0833	amino acid
I6I49_14030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I49_14035	COG0418	dihydroorotase activity
I6I49_14040	COG4251	negative regulation of phosphorylation
I6I49_14040	COG5001	Diguanylate cyclase
I6I49_14040	COG3706	GGDEF domain
I6I49_14040	COG2203	Gaf domain
I6I49_14055	COG2186	Transcriptional regulator
I6I49_14065	COG0277	FAD linked oxidase domain protein
I6I49_14070	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I49_14070	COG1902	pentaerythritol trinitrate reductase activity
I6I49_14130	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I49_14135	COG1773	rubredoxin
I6I49_14160	COG0280	phosphate acetyltransferase
I6I49_14160	COG0281	malic enzyme
I6I49_14165	COG5001	Diguanylate cyclase
I6I49_14165	COG1716	ATPase activity
I6I49_14170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I49_14175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I49_14180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I49_14220	COG1960	acyl-CoA dehydrogenase activity
I6I49_14225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I49_14230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I49_14245	COG1671	Belongs to the UPF0178 family
I6I49_14260	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I49_14265	COG1136	(ABC) transporter
I6I49_14270	COG0658	competence protein
I6I49_14270	COG2333	competence protein COMEC
I6I49_14290	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I49_14295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I49_14300	COG0628	permease
I6I49_14305	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I49_14335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I49_14355	COG0823	Involved in the tonB-independent uptake of proteins
I6I49_14375	COG0824	Thioesterase
I6I49_14390	COG2255	four-way junction helicase activity
I6I49_14405	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I49_14405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I49_14415	COG3323	Protein of unknown function (DUF1653)
I6I49_14415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I49_14420	COG0778	Nitroreductase
I6I49_14425	COG1024	Enoyl-CoA hydratase
I6I49_14430	COG1056	cytidyltransferase-related domain
I6I49_14430	COG1051	belongs to the nudix hydrolase family
I6I49_14435	COG2353	YceI-like domain
I6I49_14440	COG0583	DNA-binding transcription factor activity
I6I49_14450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I49_14465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I49_14470	COG0602	queuosine metabolic process
I6I49_14490	COG0583	DNA-binding transcription factor activity
I6I49_14495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I49_14500	COG4208	sulfate ABC transporter
I6I49_14515	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I49_14525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I49_14545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I49_14560	COG0681	Belongs to the peptidase S26 family
I6I49_14575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I49_14585	COG1381	Involved in DNA repair and RecF pathway recombination
I6I49_14590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I49_14625	COG0436	Aminotransferase
I6I49_14635	COG2199	diguanylate cyclase activity
I6I49_14650	COG0556	nucleotide-excision repair
I6I49_14680	COG0702	epimerase
I6I49_14685	COG1733	regulation of RNA biosynthetic process
I6I49_14695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I49_14700	COG0671	phosphoesterase, PA-phosphatase related
I6I49_14715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I49_14720	COG0076	glutamate decarboxylase activity
I6I49_14725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I49_14730	COG0573	inorganic phosphate transmembrane transporter activity
I6I49_14740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I49_14745	COG0616	signal peptide processing
I6I49_14750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I49_14755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I49_14760	COG1067	ATP-dependent peptidase activity
I6I49_14780	COG0254	rRNA binding
I6I49_14800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I49_14805	COG1966	Carbon starvation protein
I6I49_14810	COG2879	small protein
I6I49_14815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I49_14820	COG0714	Associated with various cellular activities
I6I49_14970	COG0582	viral genome integration into host DNA
I6I49_15120	COG5410	chromosome segregation
I6I49_15205	COG2357	RelA SpoT domain protein
I6I49_15325	COG1802	Transcriptional regulator
I6I49_15325	COG4626	Terminase
I6I49_15330	COG4695	Portal protein
I6I49_15335	COG0740	serine-type endopeptidase activity
I6I49_15455	COG1538	Outer membrane efflux protein
I6I49_15490	COG1131	(ABC) transporter
I6I49_15495	COG0842	Transport permease protein
I6I49_15500	COG0842	Transport permease protein
I6I49_15525	COG1309	transcriptional regulator
I6I49_15610	COG1733	regulation of RNA biosynthetic process
I6I49_15615	COG0604	alcohol dehydrogenase
I6I49_15640	COG1278	Cold shock
I6I49_15660	COG3038	cytochrome b561
I6I49_15670	COG2070	2-Nitropropane dioxygenase
I6I49_15695	COG3634	alkyl hydroperoxide reductase activity
I6I49_15715	COG0436	Aminotransferase
I6I49_15720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I49_15725	COG0386	Belongs to the glutathione peroxidase family
I6I49_15745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I49_15760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I49_15785	COG0012	GTP binding
I6I49_15795	COG2011	ABC-type metal ion transport system permease component
I6I49_15800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I49_15805	COG1464	Belongs to the NlpA lipoprotein family
I6I49_15810	COG1464	Belongs to the NlpA lipoprotein family
I6I49_15855	COG3293	Transposase
I6I49_15900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I49_15905	COG0730	response to heat
I6I49_15925	COG4773	Receptor
I6I49_15930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I49_15935	COG1944	ATP diphosphatase activity
I6I49_15940	COG2207	Transcriptional regulator
I6I49_15945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I49_15950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I49_15980	COG2223	nitrite transmembrane transporter activity
I6I49_16020	COG1380	Effector of murein hydrolase LrgA
I6I49_16025	COG0583	DNA-binding transcription factor activity
I6I49_16065	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I49_16195	COG5410	chromosome segregation
I6I49_16200	COG3567	Phage-associated protein, HI1409 family
I6I49_16205	COG2369	cell adhesion
I6I49_16335	COG3772	lysozyme
I6I49_16345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I49_16420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I49_16425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I49_16455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I49_16480	COG1132	(ABC) transporter
I6I49_16490	COG0668	transmembrane transport
I6I49_16495	COG3122	Protein conserved in bacteria
I6I49_16520	COG0640	Transcriptional regulator
I6I49_16525	COG0596	Alpha beta hydrolase
I6I49_16550	COG1335	isochorismatase
I6I49_16555	COG0251	oxidation-reduction process
I6I49_16560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I49_16565	COG2233	PERMEase
I6I49_16580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I49_16590	COG0183	Belongs to the thiolase family
I6I49_16595	COG0583	DNA-binding transcription factor activity
I6I49_16610	COG0439	Biotin carboxylase
I6I49_16625	COG0511	ligase activity, forming carbon-carbon bonds
I6I49_16640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I49_16645	COG0183	Belongs to the thiolase family
I6I49_16650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I49_16655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I49_16660	COG3135	benzoate transporter
I6I49_16665	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_16670	COG0633	Ferredoxin
I6I49_16670	COG0543	2 iron, 2 sulfur cluster binding
I6I49_16680	COG2814	Major facilitator Superfamily
I6I49_16725	COG2963	transposase activity
I6I49_16775	COG4774	siderophore transport
I6I49_16820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I49_16825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I49_16830	COG0022	dehydrogenase e1 component
I6I49_16835	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I49_16860	COG1063	alcohol dehydrogenase
I6I49_16865	COG4628	conserved protein (DUF2132)
I6I49_16870	COG2801	Transposase and inactivated derivatives
I6I49_16935	COG0596	Alpha beta hydrolase
I6I49_17005	COG0864	Transcriptional regulator
I6I49_17030	COG2814	Major facilitator Superfamily
I6I49_17085	COG1960	acyl-CoA dehydrogenase activity
I6I49_17090	COG1960	acyl-CoA dehydrogenase activity
I6I49_17140	COG0552	protein localization to endoplasmic reticulum
I6I49_17145	COG0612	Peptidase, M16
I6I49_17170	COG0517	IMP dehydrogenase activity
I6I49_17170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I49_17175	COG0133	tryptophan synthase activity
I6I49_17185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I49_17200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I49_17205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I49_17245	COG0537	adenosine 5'-monophosphoramidase activity
I6I49_17275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I49_17280	COG0776	regulation of translation
I6I49_17295	COG1959	2 iron, 2 sulfur cluster binding
I6I49_17305	COG0822	iron-sulfur transferase activity
I6I49_17310	COG0316	Belongs to the HesB IscA family
I6I49_17340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I49_17350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I49_17360	COG0506	proline dehydrogenase activity
I6I49_17360	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I49_17360	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I49_17390	COG3781	membrane
I6I49_17395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I49_17405	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I49_17425	COG0697	spore germination
I6I49_17440	COG0126	phosphoglycerate kinase activity
I6I49_17450	COG0424	maF-like protein
I6I49_17460	COG2850	peptidyl-arginine hydroxylation
I6I49_17465	COG4585	Histidine kinase
I6I49_17470	COG2197	response regulator
I6I49_17480	COG0069	glutamate synthase activity
I6I49_17500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I49_17505	COG1454	alcohol dehydrogenase
I6I49_17510	COG0824	Thioesterase
I6I49_17515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I49_17535	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_17540	COG0183	Belongs to the thiolase family
I6I49_17555	COG0583	DNA-binding transcription factor activity
I6I49_17560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I49_17570	COG3135	benzoate transporter
I6I49_17575	COG1309	transcriptional regulator
I6I49_17580	COG2076	Multidrug Resistance protein
I6I49_17595	COG0589	response to stress
I6I49_17605	COG0308	aminopeptidase N
I6I49_17630	COG1253	flavin adenine dinucleotide binding
I6I49_17635	COG3293	Transposase
I6I49_17655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I49_17660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I49_17675	COG2431	L-lysine efflux transmembrane transporter activity
I6I49_17690	COG0776	regulation of translation
I6I49_17710	COG0590	tRNA wobble adenosine to inosine editing
I6I49_17720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I49_17755	COG0084	hydrolase, TatD family'
I6I49_17775	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I49_17780	COG1132	(ABC) transporter
I6I49_17790	COG0811	peptide transport
I6I49_17795	COG1475	DNA binding
I6I49_17800	COG1192	Involved in chromosome partitioning
I6I49_17810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I49_17815	COG3178	'Phosphotransferase
I6I49_17825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I49_17830	COG1923	regulation of RNA biosynthetic process
I6I49_17840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I49_17845	COG0802	atpase or kinase
I6I49_17850	COG0564	pseudouridine synthase activity
I6I49_17865	COG1187	pseudouridine synthase activity
I6I49_17870	COG2707	UPF0756 membrane protein
I6I49_17875	COG2814	Major facilitator Superfamily
I6I49_17880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I49_17885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I49_17895	COG1454	alcohol dehydrogenase
I6I49_17915	COG0531	amino acid
I6I49_17920	COG4303	Ethanolamine ammonia lyase large subunit
I6I49_17925	COG4302	ethanolamine ammonia-lyase activity
I6I49_17935	COG1028	Short-chain dehydrogenase reductase Sdr
I6I49_17945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I49_17945	COG0519	Catalyzes the synthesis of GMP from XMP
I6I49_17950	COG2353	YceI-like domain
I6I49_17955	COG0456	acetyltransferase
I6I49_17965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I49_17970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I49_18015	COG0352	thiamine-phosphate diphosphorylase activity
I6I49_18060	COG0612	Peptidase, M16
I6I49_18070	COG1823	symporter activity
I6I49_18075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I49_18115	COG2351	hydroxyisourate hydrolase activity
I6I49_18125	COG1686	Belongs to the peptidase S11 family
I6I49_18130	COG1252	NADH dehydrogenase
I6I49_18135	COG1047	Peptidyl-prolyl cis-trans
I6I49_18145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I49_18145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I49_18165	COG0318	PFAM AMP-dependent synthetase and ligase
I6I49_18170	COG2819	hydrolase of the alpha beta superfamily
I6I49_18180	COG0372	Belongs to the citrate synthase family
I6I49_18210	COG0542	response to heat
I6I49_18215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I49_18230	COG3706	GGDEF domain
I6I49_18240	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I49_18245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I49_18255	COG0569	domain protein
I6I49_18260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I49_18280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I49_18290	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I49_18305	COG1294	oxidase, subunit
I6I49_18310	COG4890	Cyd operon protein YbgT
I6I49_18325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I49_18330	COG1309	transcriptional regulator
I6I49_18335	COG1012	belongs to the aldehyde dehydrogenase family
I6I49_18345	COG0579	oxidoreductase
I6I49_18360	COG0772	Belongs to the SEDS family
I6I49_18375	COG0148	phosphopyruvate hydratase activity
I6I49_18395	COG0583	DNA-binding transcription factor activity
I6I49_18405	COG2814	Major facilitator Superfamily
I6I49_18420	COG1902	pentaerythritol trinitrate reductase activity
I6I49_18420	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I49_18440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I49_18445	COG0702	epimerase
I6I49_18485	COG1011	Hydrolase
I6I49_18490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I49_18495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I49_18500	COG2137	regulation of response to DNA damage stimulus
I6I49_18530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I49_18540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I49_18550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I49_18565	COG0575	Belongs to the CDS family
I6I49_18570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I49_18590	COG3852	Histidine kinase
I6I49_18595	COG2204	response regulator
I6I49_18605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I49_18610	COG0583	DNA-binding transcription factor activity
I6I49_18615	COG0024	Methionine aminopeptidase
I6I49_18645	COG1113	amino acid transport
I6I49_18655	COG0786	glutamate:sodium symporter activity
I6I49_18730	COG0729	surface antigen
I6I49_18755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I49_18775	COG1960	acyl-CoA dehydrogenase activity
I6I49_18805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I49_18810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I49_18815	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I49_18820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I49_18835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I49_18865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I49_18870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I49_18875	COG1845	cytochrome c oxidase, subunit III
I6I49_18880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I49_18910	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I49_18925	COG0305	Participates in initiation and elongation during chromosome replication
I6I49_18930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I49_18945	COG1305	Transglutaminase-like
I6I49_18955	COG2308	Evidence 4 Homologs of previously reported genes of
I6I49_18970	COG0445	tRNA wobble uridine modification
I6I49_19000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I49_19005	COG0138	bifunctional purine biosynthesis protein purh
I6I49_19010	COG0151	Belongs to the GarS family
I6I49_19020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I49_19025	COG2011	ABC-type metal ion transport system permease component
I6I49_19090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I49_19100	COG4122	O-methyltransferase activity
I6I49_19120	COG1137	ATPase activity
I6I49_19125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I49_19135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I49_19140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I49_19140	COG0517	IMP dehydrogenase activity
I6I49_19150	COG0406	alpha-ribazole phosphatase activity
I6I49_19155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I49_19190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I49_19200	COG0243	molybdopterin cofactor binding
I6I49_19205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I49_19210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I49_19215	COG2223	nitrite transmembrane transporter activity
I6I49_19225	COG1116	anion transmembrane transporter activity
I6I49_19225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I49_19245	COG1643	Atp-dependent helicase
I6I49_19255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I49_19290	COG0515	serine threonine protein kinase
I6I49_19290	COG2815	serine threonine protein kinase
I6I49_19345	COG1610	YqeY-like protein
I6I49_19350	COG4783	chaperone-mediated protein folding
I6I49_19410	COG0778	Nitroreductase
I6I49_19420	COG0513	Belongs to the DEAD box helicase family
I6I49_19425	COG1278	Cold shock
I6I49_19440	COG2363	Small membrane protein
I6I49_19470	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I49_19475	COG0625	glutathione transferase activity
I6I49_19480	COG0659	secondary active sulfate transmembrane transporter activity
I6I49_19490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I49_19525	COG0318	PFAM AMP-dependent synthetase and ligase
I6I49_19530	COG1309	transcriptional regulator
I6I49_19535	COG1960	acyl-CoA dehydrogenase activity
I6I49_19540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I49_19550	COG4770	biotin carboxylase activity
I6I49_19580	COG2031	fatty acid transporter
I6I49_19605	COG0675	Transposase, IS605 OrfB family
I6I49_19630	COG0540	Belongs to the ATCase OTCase family
I6I49_19655	COG1765	OsmC-like protein
I6I49_19665	COG0667	Aldo Keto reductase
I6I49_19680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I49_19700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I49_19715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I49_19730	COG0527	aspartate kinase activity
I6I49_19745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I49_19760	COG3038	cytochrome b561
I6I49_19770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I49_19775	COG2252	PERMEase
I6I49_19785	COG0415	Belongs to the DNA photolyase family
I6I49_19805	COG3335	DDE superfamily endonuclease
I6I49_19825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I49_19875	COG0640	Transcriptional regulator
I6I49_19955	COG1192	Involved in chromosome partitioning
I6I49_19960	COG1475	DNA binding
I6I49_20135	COG3293	Transposase
I6I49_20190	COG0560	Phosphoserine phosphatase
I6I49_20240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I49_20385	COG4372	Transposase
I6I49_20650	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I49_20685	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I49_20745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I49_20770	COG1280	lysine exporter protein (LysE YggA)
I6I49_20780	COG1280	lysine exporter protein (LysE YggA)