locus-tag	class	description
I6I50_00015	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I50_00020	COG2252	PERMEase
I6I50_00030	COG0415	Belongs to the DNA photolyase family
I6I50_00060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I50_00065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I50_00075	COG0693	protein deglycase activity
I6I50_00080	COG1960	acyl-CoA dehydrogenase activity
I6I50_00085	COG1301	dicarboxylic acid transport
I6I50_00100	COG3139	Protein of unknown function (DUF1315)
I6I50_00105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I50_00110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I50_00120	COG0494	nUDIX hydrolase
I6I50_00130	COG0642	Histidine kinase
I6I50_00145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I50_00155	COG1720	tRNA m6t6A37 methyltransferase activity
I6I50_00220	COG0826	peptidase U32
I6I50_00225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I50_00230	COG3634	alkyl hydroperoxide reductase activity
I6I50_00250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I50_00255	COG3385	transposase activity
I6I50_00320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I50_00320	COG0475	glutathione-regulated potassium exporter activity
I6I50_00325	COG0697	spore germination
I6I50_00330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I50_00340	COG0235	Class ii aldolase
I6I50_00365	COG4149	molybdate abc transporter
I6I50_00370	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I50_00380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I50_00390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I50_00395	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I50_00395	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I50_00400	COG0303	'Molybdopterin
I6I50_00410	COG1131	(ABC) transporter
I6I50_00415	COG0842	Transport permease protein
I6I50_00430	COG2951	lytic endotransglycosylase activity
I6I50_00465	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I50_00500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I50_00505	COG0842	Transport permease protein
I6I50_00540	COG1280	lysine exporter protein (LysE YggA)
I6I50_00545	COG1522	sequence-specific DNA binding
I6I50_00550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I50_00560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I50_00570	COG0019	diaminopimelate decarboxylase activity
I6I50_00580	COG1113	amino acid transport
I6I50_00585	COG1115	amino acid carrier protein
I6I50_00600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I50_00605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I50_00610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I50_00615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I50_00655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I50_00660	COG3161	chorismate lyase activity
I6I50_00670	COG0174	glutamine synthetase
I6I50_00675	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I50_00680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I50_00685	COG0134	indole-3-glycerol-phosphate synthase activity
I6I50_00700	COG0302	gtp cyclohydrolase
I6I50_00710	COG3706	GGDEF domain
I6I50_00725	COG3739	integral membrane protein
I6I50_00745	COG1741	Belongs to the pirin family
I6I50_00760	COG1309	transcriptional regulator
I6I50_00790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I50_00795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I50_00805	COG0037	tRNA processing
I6I50_00810	COG0741	lytic transglycosylase activity
I6I50_00815	COG0501	Belongs to the peptidase M48B family
I6I50_00830	COG2239	Acts as a magnesium transporter
I6I50_00860	COG1253	flavin adenine dinucleotide binding
I6I50_00865	COG2851	Citrate transporter
I6I50_00905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I50_00910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I50_00935	COG0505	Belongs to the CarA family
I6I50_00940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I50_00950	COG0110	maltose O-acetyltransferase activity
I6I50_00965	COG3695	enzyme binding
I6I50_00980	COG2321	neutral zinc metallopeptidase
I6I50_00985	COG2354	Protein conserved in bacteria
I6I50_00995	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I50_01000	COG2268	Band 7 protein
I6I50_01010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I50_01020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I50_01035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I50_01040	COG1053	succinate dehydrogenase
I6I50_01045	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I50_01050	COG2009	succinate dehydrogenase
I6I50_01060	COG2072	flavoprotein involved in K transport
I6I50_01080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I50_01080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I50_01105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I50_01130	COG0564	pseudouridine synthase activity
I6I50_01140	COG0358	DNA primase activity
I6I50_01155	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I50_01185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I50_01190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I50_01240	COG0586	Pfam SNARE associated Golgi protein
I6I50_01255	COG1280	lysine exporter protein (LysE YggA)
I6I50_01275	COG2921	Belongs to the UPF0250 family
I6I50_01280	COG0321	lipoyl(octanoyl) transferase activity
I6I50_01295	COG0531	amino acid
I6I50_01305	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_01315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I50_01320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I50_01320	COG1648	precorrin-2 dehydrogenase activity
I6I50_01325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I50_01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I50_01350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I50_01370	COG0671	phosphoesterase, PA-phosphatase related
I6I50_01375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I50_01385	COG1538	Outer membrane efflux protein
I6I50_01390	COG0393	Putative heavy-metal-binding
I6I50_01405	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_01415	COG0525	valine-tRNA ligase activity
I6I50_01430	COG2852	Protein conserved in bacteria
I6I50_01445	COG0583	DNA-binding transcription factor activity
I6I50_01450	COG1278	Cold shock
I6I50_01455	COG1278	Cold shock
I6I50_01475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I50_01480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I50_01485	COG0713	ATP synthesis coupled electron transport
I6I50_01495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I50_01510	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I50_01530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I50_01540	COG2205	protein histidine kinase activity
I6I50_01545	COG0745	RESPONSE REGULATOR receiver
I6I50_01560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I50_01580	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_01685	COG0439	Biotin carboxylase
I6I50_01690	COG1802	Transcriptional regulator
I6I50_01695	COG1652	LysM domain
I6I50_01705	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_01720	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I50_01725	COG3101	peptidyl-lysine hydroxylation
I6I50_01730	COG0009	L-threonylcarbamoyladenylate synthase
I6I50_01740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I50_01745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I50_01790	COG4106	trans-aconitate 2-methyltransferase activity
I6I50_01805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I50_01805	COG0596	Alpha beta hydrolase
I6I50_01805	COG2226	methyltransferase
I6I50_01810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I50_01815	COG2193	ferroxidase activity
I6I50_01840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I50_01845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I50_01850	COG3115	cell septum assembly
I6I50_01855	COG1196	nuclear chromosome segregation
I6I50_01865	COG0730	response to heat
I6I50_01885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I50_01925	COG3422	double-strand break repair
I6I50_01935	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I50_01940	COG3189	MarR family transcriptional regulator
I6I50_01960	COG0564	pseudouridine synthase activity
I6I50_01965	COG0346	lactoylglutathione lyase activity
I6I50_02015	COG2801	Transposase and inactivated derivatives
I6I50_02040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I50_02075	COG3659	wide pore channel activity
I6I50_02085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I50_02105	COG1970	mechanosensitive ion channel activity
I6I50_02110	COG1217	gtp-binding protein TYPA
I6I50_02115	COG2233	PERMEase
I6I50_02125	COG0833	amino acid
I6I50_02140	COG0183	Belongs to the thiolase family
I6I50_02160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I50_02175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I50_02180	COG2207	Transcriptional regulator
I6I50_02185	COG0183	Belongs to the thiolase family
I6I50_02190	COG1024	Enoyl-CoA hydratase
I6I50_02190	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I50_02210	COG1272	protein, Hemolysin III
I6I50_02215	COG0477	Major facilitator Superfamily
I6I50_02225	COG1408	metallophosphoesterase
I6I50_02230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I50_02240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I50_02270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I50_02275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I50_02280	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I50_02285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I50_02290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I50_02300	COG0625	glutathione transferase activity
I6I50_02305	COG2969	positive regulation of protein catabolic process
I6I50_02365	COG2199	diguanylate cyclase activity
I6I50_02395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I50_02400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I50_02425	COG0450	alkyl hydroperoxide reductase
I6I50_02445	COG0285	dihydrofolate synthase activity
I6I50_02495	COG4206	TonB-dependent receptor
I6I50_02500	COG2096	Adenosyltransferase
I6I50_02520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I50_02525	COG2315	Protein conserved in bacteria
I6I50_02535	COG1113	amino acid transport
I6I50_02540	COG0745	RESPONSE REGULATOR receiver
I6I50_02545	COG2205	protein histidine kinase activity
I6I50_02555	COG1960	acyl-CoA dehydrogenase activity
I6I50_02560	COG1960	acyl-CoA dehydrogenase activity
I6I50_02565	COG3223	Belongs to the PsiE family
I6I50_02595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I50_02615	COG3306	glycosyltransferase involved in LPS biosynthesis
I6I50_02645	COG0438	transferase activity, transferring glycosyl groups
I6I50_02660	COG3293	Transposase
I6I50_02670	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I50_02675	COG5002	protein histidine kinase activity
I6I50_02685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I50_02695	COG1704	LemA family
I6I50_02705	COG1862	Preprotein translocase
I6I50_02745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I50_02765	COG1426	Protein conserved in bacteria
I6I50_02825	COG0440	acetolactate synthase activity
I6I50_02830	COG0028	Belongs to the TPP enzyme family
I6I50_02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I50_02860	COG1136	(ABC) transporter
I6I50_02860	COG0577	efflux transmembrane transporter activity
I6I50_02900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I50_02905	COG1162	GTPase activity
I6I50_02930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I50_02940	COG3781	membrane
I6I50_02945	COG0613	PHP domain protein
I6I50_02955	COG2350	Protein conserved in bacteria
I6I50_02975	COG1666	GTP binding
I6I50_02990	COG1607	acyl-coa hydrolase
I6I50_03050	COG1183	phosphatidylcholine synthase activity
I6I50_03055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I50_03080	COG0039	L-malate dehydrogenase activity
I6I50_03090	COG0741	lytic transglycosylase activity
I6I50_03090	COG1196	nuclear chromosome segregation
I6I50_03090	COG0739	heme binding
I6I50_03095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I50_03100	COG1702	phosphate starvation-inducible protein PhoH
I6I50_03105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I50_03150	COG1295	ribonuclease BN
I6I50_03165	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I50_03180	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_03190	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6I50_03205	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_03240	COG0753	catalase activity
I6I50_03250	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_03270	COG0557	exoribonuclease II activity
I6I50_03275	COG2720	vancomycin resistance protein
I6I50_03280	COG0339	signal peptide processing
I6I50_03285	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I50_03320	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I50_03325	COG1960	acyl-CoA dehydrogenase activity
I6I50_03330	COG3385	transposase activity
I6I50_03340	COG2072	flavoprotein involved in K transport
I6I50_03345	COG0203	ribosomal protein L17
I6I50_03350	COG0202	RNA polymerase activity
I6I50_03365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I50_03390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I50_03400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I50_03405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I50_03455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I50_03470	COG0088	Forms part of the polypeptide exit tunnel
I6I50_03475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I50_03495	COG0433	COG0433 Predicted ATPase
I6I50_03505	COG1959	2 iron, 2 sulfur cluster binding
I6I50_03520	COG1301	dicarboxylic acid transport
I6I50_03525	COG1946	Acyl-CoA thioesterase
I6I50_03530	COG2937	Belongs to the GPAT DAPAT family
I6I50_03550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I50_03555	COG1040	competence protein
I6I50_03560	COG0494	nUDIX hydrolase
I6I50_03570	COG0598	Magnesium transport protein CorA
I6I50_03580	COG2854	intermembrane phospholipid transfer
I6I50_03585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I50_03590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I50_03595	COG1127	ABC transporter
I6I50_03600	COG0513	Belongs to the DEAD box helicase family
I6I50_03605	COG3385	transposase activity
I6I50_03625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I50_03630	COG0408	coproporphyrinogen oxidase activity
I6I50_03650	COG1960	acyl-CoA dehydrogenase activity
I6I50_03675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I50_03685	COG0534	Mate efflux family protein
I6I50_03695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I50_03700	COG0254	rRNA binding
I6I50_03705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I50_03720	COG2226	methyltransferase
I6I50_03730	COG1192	Involved in chromosome partitioning
I6I50_03735	COG0628	permease
I6I50_03755	COG1289	transmembrane transporter activity
I6I50_03760	COG2814	Major facilitator Superfamily
I6I50_03820	COG0277	FAD linked oxidase domain protein
I6I50_03825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I50_03830	COG5006	permease, DMT superfamily
I6I50_03835	COG5006	permease, DMT superfamily
I6I50_03850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I50_03855	COG5380	lipid catabolic process
I6I50_03870	COG0335	large ribosomal subunit rRNA binding
I6I50_03880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I50_03885	COG0228	four-way junction DNA binding
I6I50_03925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I50_03930	COG0194	GDP metabolic process
I6I50_03935	COG1758	RNA polymerase activity
I6I50_03940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I50_03975	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I50_03980	COG1704	LemA family
I6I50_03990	COG0493	'glutamate synthase
I6I50_03995	COG0067	glutamate synthase
I6I50_03995	COG0069	glutamate synthase activity
I6I50_03995	COG0070	glutamate synthase
I6I50_04045	COG2226	methyltransferase
I6I50_04055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I50_04060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I50_04080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I50_04135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I50_04155	COG0488	(ABC) transporter
I6I50_04160	COG2873	o-acetylhomoserine
I6I50_04165	COG4221	oxidoreductase activity
I6I50_04195	COG0427	acetyl-CoA hydrolase
I6I50_04230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I50_04260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I50_04265	COG0531	amino acid
I6I50_04280	COG1278	Cold shock
I6I50_04285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I50_04350	COG2205	protein histidine kinase activity
I6I50_04390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I50_04395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I50_04405	COG0659	secondary active sulfate transmembrane transporter activity
I6I50_04410	COG2801	Transposase and inactivated derivatives
I6I50_04415	COG0753	catalase activity
I6I50_04420	COG3706	GGDEF domain
I6I50_04425	COG3077	Addiction module antitoxin, RelB DinJ family
I6I50_04475	COG2801	Transposase and inactivated derivatives
I6I50_04480	COG3842	ATPase activity
I6I50_04485	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I50_04550	COG3158	transport of potassium into the cell
I6I50_04575	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6I50_04595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I50_04615	COG0583	DNA-binding transcription factor activity
I6I50_04625	COG1196	nuclear chromosome segregation
I6I50_04660	COG0629	single-stranded DNA binding
I6I50_04665	COG2814	Major facilitator Superfamily
I6I50_04675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I50_04675	COG0352	thiamine-phosphate diphosphorylase activity
I6I50_04675	COG0351	phosphomethylpyrimidine kinase
I6I50_04700	COG3293	Transposase
I6I50_04705	COG3706	GGDEF domain
I6I50_04725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I50_04730	COG3162	membrane
I6I50_04735	COG2205	protein histidine kinase activity
I6I50_04735	COG0784	Response regulator, receiver
I6I50_04750	COG0431	NADPH-dependent FMN reductase
I6I50_04770	COG0307	riboflavin synthase, alpha
I6I50_04775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I50_04780	COG0668	transmembrane transport
I6I50_04785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I50_04795	COG1519	Transferase
I6I50_04800	COG1902	pentaerythritol trinitrate reductase activity
I6I50_04825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I50_04860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I50_04860	COG0426	domain, Protein
I6I50_04865	COG2119	membrane
I6I50_04895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I50_04905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I50_04915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I50_04925	COG0189	ligase activity
I6I50_04930	COG0386	Belongs to the glutathione peroxidase family
I6I50_04935	COG1846	Transcriptional regulator
I6I50_04950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I50_04960	COG0708	Exodeoxyribonuclease III
I6I50_04965	COG1393	Belongs to the ArsC family
I6I50_04980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I50_05075	COG3150	esterase
I6I50_05085	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I50_05090	COG2918	glutathione biosynthetic process
I6I50_05105	COG2733	membrane
I6I50_05110	COG0436	Aminotransferase
I6I50_05115	COG0534	Mate efflux family protein
I6I50_05185	COG0385	Bile acid
I6I50_05190	COG1335	isochorismatase
I6I50_05195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I50_05215	COG4215	(ABC) transporter
I6I50_05220	COG4160	amino acid transport
I6I50_05240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I50_05245	COG2983	Belongs to the UPF0260 family
I6I50_05250	COG5487	UPF0391 membrane protein
I6I50_05285	COG2818	Glycosylase
I6I50_05290	COG1064	alcohol dehydrogenase
I6I50_05295	COG0436	Aminotransferase
I6I50_05310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I50_05320	COG0484	heat shock protein binding
I6I50_05340	COG1309	transcriptional regulator
I6I50_05350	COG2233	PERMEase
I6I50_05355	COG0583	DNA-binding transcription factor activity
I6I50_05375	COG0129	dihydroxy-acid dehydratase activity
I6I50_05390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I50_05390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I50_05410	COG3188	usher protein
I6I50_05425	COG4372	Transposase
I6I50_05430	COG3188	usher protein
I6I50_05445	COG0733	neurotransmitter:sodium symporter activity
I6I50_05455	COG2814	Major facilitator Superfamily
I6I50_05485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I50_05490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I50_05495	COG2951	lytic endotransglycosylase activity
I6I50_05500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I50_05515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I50_05535	COG0861	Integral membrane protein TerC family
I6I50_05545	COG0754	glutathionylspermidine amidase activity
I6I50_05555	COG0402	S-adenosylhomocysteine deaminase activity
I6I50_05575	COG1230	cation diffusion facilitator family transporter
I6I50_05610	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_05675	COG0582	viral genome integration into host DNA
I6I50_05685	COG0706	membrane insertase activity
I6I50_05690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I50_05705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I50_05710	COG0592	DNA-directed DNA polymerase activity
I6I50_05720	COG0187	DNA topoisomerase II activity
I6I50_05730	COG0488	(ABC) transporter
I6I50_05755	COG3385	transposase activity
I6I50_05805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I50_05835	COG2133	pyrroloquinoline quinone binding
I6I50_05850	COG1047	Peptidyl-prolyl cis-trans
I6I50_05855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I50_05860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I50_05865	COG0196	riboflavin kinase activity
I6I50_05880	COG1309	transcriptional regulator
I6I50_05885	COG1116	anion transmembrane transporter activity
I6I50_05890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I50_05895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I50_05900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I50_05905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I50_05910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I50_05910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I50_05935	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_05940	COG0546	phosphoglycolate phosphatase activity
I6I50_05945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I50_05950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I50_05955	COG3307	-O-antigen
I6I50_05965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I50_05975	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I50_05980	COG0728	peptidoglycan biosynthetic process
I6I50_06010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I50_06035	COG0438	transferase activity, transferring glycosyl groups
I6I50_06040	COG0438	transferase activity, transferring glycosyl groups
I6I50_06045	COG0438	transferase activity, transferring glycosyl groups
I6I50_06050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I50_06055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I50_06065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I50_06080	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I50_06100	COG1442	glycosyl transferase family 8
I6I50_06100	COG1216	Glycosyl transferase, family 2
I6I50_06105	COG0463	Glycosyl transferase, family 2
I6I50_06120	COG1216	Glycosyl transferase, family 2
I6I50_06125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I50_06130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I50_06145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I50_06155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I50_06210	COG4372	Transposase
I6I50_06215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I50_06225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I50_06230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I50_06240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I50_06255	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I50_06260	COG0583	DNA-binding transcription factor activity
I6I50_06280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I50_06305	COG2986	histidine ammonia-lyase
I6I50_06335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I50_06345	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_06350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I50_06360	COG4628	conserved protein (DUF2132)
I6I50_06440	COG1538	Outer membrane efflux protein
I6I50_06445	COG1132	(ABC) transporter
I6I50_06475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I50_06480	COG3550	peptidyl-serine autophosphorylation
I6I50_06495	COG2197	response regulator
I6I50_06515	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I50_06525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I50_06550	COG1116	anion transmembrane transporter activity
I6I50_06550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I50_06555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I50_06560	COG1116	anion transmembrane transporter activity
I6I50_06585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I50_06585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I50_06590	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I50_06595	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I50_06595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I50_06595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I50_06605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I50_06640	COG3756	Protein conserved in bacteria
I6I50_06675	COG0271	Belongs to the BolA IbaG family
I6I50_06685	COG1192	Involved in chromosome partitioning
I6I50_06700	COG0586	Pfam SNARE associated Golgi protein
I6I50_06715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I50_06715	COG0519	Catalyzes the synthesis of GMP from XMP
I6I50_06720	COG1715	Restriction endonuclease
I6I50_06765	COG0281	malic enzyme
I6I50_06790	COG2837	iron assimilation
I6I50_06800	COG1683	Conserved Protein
I6I50_06805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I50_06810	COG1121	(ABC) transporter
I6I50_06860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I50_06895	COG0386	Belongs to the glutathione peroxidase family
I6I50_06905	COG0697	spore germination
I6I50_06915	COG0758	DNA mediated transformation
I6I50_06985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I50_06995	COG2814	Major facilitator Superfamily
I6I50_07015	COG1253	flavin adenine dinucleotide binding
I6I50_07020	COG3012	SEC-C Motif Domain Protein
I6I50_07025	COG2860	membrane
I6I50_07030	COG0477	Major facilitator Superfamily
I6I50_07040	COG0318	PFAM AMP-dependent synthetase and ligase
I6I50_07055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I50_07075	COG0606	chelatase, subunit chli
I6I50_07085	COG0347	Belongs to the P(II) protein family
I6I50_07090	COG0004	ammonium transporteR
I6I50_07100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I50_07100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I50_07115	COG0586	Pfam SNARE associated Golgi protein
I6I50_07135	COG0795	lipopolysaccharide-transporting ATPase activity
I6I50_07140	COG0795	lipopolysaccharide-transporting ATPase activity
I6I50_07145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I50_07150	COG0793	Belongs to the peptidase S41A family
I6I50_07165	COG2197	response regulator
I6I50_07170	COG1686	Belongs to the peptidase S11 family
I6I50_07175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I50_07185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I50_07190	COG4974	Belongs to the 'phage' integrase family
I6I50_07210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I50_07215	COG0772	Belongs to the SEDS family
I6I50_07220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I50_07225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I50_07230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I50_07240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I50_07250	COG1538	Outer membrane efflux protein
I6I50_07270	COG3275	phosphorelay sensor kinase activity
I6I50_07280	COG0181	hydroxymethylbilane synthase activity
I6I50_07300	COG0824	Thioesterase
I6I50_07330	COG0546	phosphoglycolate phosphatase activity
I6I50_07380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I50_07385	COG0081	regulation of translation
I6I50_07390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I50_07395	COG0222	ribosome binding
I6I50_07400	COG0085	RNA polymerase activity
I6I50_07405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I50_07435	COG2056	Na+-H+ antiporter family
I6I50_07440	COG3047	cAMP biosynthetic process
I6I50_07450	COG0326	Molecular chaperone. Has ATPase activity
I6I50_07485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I50_07565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I50_07570	COG1132	(ABC) transporter
I6I50_07585	COG1289	transmembrane transporter activity
I6I50_07600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I50_07605	COG1678	Uncharacterized ACR, COG1678
I6I50_07610	COG0497	DNA recombination
I6I50_07620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I50_07630	COG0237	dephospho-CoA kinase activity
I6I50_07690	COG0195	Participates in both transcription termination and antitermination
I6I50_07700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I50_07705	COG1320	monovalent cation:proton antiporter activity
I6I50_07710	COG2212	antiporter activity
I6I50_07715	COG1863	multisubunit Na H antiporter MnhE subunit
I6I50_07720	COG0651	ATP synthesis coupled electron transport
I6I50_07725	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I50_07730	COG2111	Na H antiporter
I6I50_07730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I50_07735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I50_07745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I50_07765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I50_07795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I50_07800	COG1074	ATP-dependent DNA helicase activity
I6I50_07805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I50_07810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I50_07820	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I50_07825	COG0598	Magnesium transport protein CorA
I6I50_07830	COG2841	Protein conserved in bacteria
I6I50_07850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I50_07860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I50_07880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I50_07885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I50_07890	COG4535	Mg2 and Co2 transporter CorC
I6I50_07895	COG0425	Belongs to the sulfur carrier protein TusA family
I6I50_07915	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I50_07915	COG0644	oxidoreductase
I6I50_07925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I50_07935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I50_07940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I50_07945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I50_07955	COG0493	'glutamate synthase
I6I50_07955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I50_07970	COG2226	methyltransferase
I6I50_07985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I50_08015	COG0751	glycine-tRNA ligase activity
I6I50_08065	COG0318	PFAM AMP-dependent synthetase and ligase
I6I50_08070	COG1530	ribonuclease E activity
I6I50_08090	COG0583	DNA-binding transcription factor activity
I6I50_08120	COG1960	acyl-CoA dehydrogenase activity
I6I50_08135	COG1280	lysine exporter protein (LysE YggA)
I6I50_08170	COG0583	DNA-binding transcription factor activity
I6I50_08180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I50_08195	COG0473	3-isopropylmalate dehydrogenase activity
I6I50_08250	COG1560	Kdo2-lipid A biosynthetic process
I6I50_08255	COG0488	(ABC) transporter
I6I50_08260	COG2900	Belongs to the SlyX family
I6I50_08300	COG1929	Belongs to the glycerate kinase type-1 family
I6I50_08305	COG0210	DNA helicase
I6I50_08330	COG4651	solute:proton antiporter activity
I6I50_08330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I50_08355	COG0788	formyltetrahydrofolate deformylase activity
I6I50_08465	COG2813	Specifically methylates the guanine in position
I6I50_08465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I50_08475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I50_08490	COG4774	siderophore transport
I6I50_08515	COG0740	serine-type endopeptidase activity
I6I50_08535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I50_08535	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I50_08540	COG1917	Cupin 2, conserved barrel domain protein
I6I50_08540	COG2207	Transcriptional regulator
I6I50_08550	COG2318	DinB family
I6I50_08565	COG0280	phosphate acetyltransferase
I6I50_08565	COG0857	belongs to the CobB CobQ family
I6I50_08570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I50_08575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I50_08580	COG2267	carboxylic ester hydrolase activity
I6I50_08595	COG0793	Belongs to the peptidase S41A family
I6I50_08605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I50_08620	COG0084	hydrolase, TatD family'
I6I50_08630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I50_08650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I50_08830	COG0640	Transcriptional regulator
I6I50_08840	COG0798	PFAM Bile acid sodium symporter
I6I50_08845	COG0431	NADPH-dependent FMN reductase
I6I50_08850	COG0492	ferredoxin-NADP+ reductase activity
I6I50_08870	COG2814	Major facilitator Superfamily
I6I50_08895	COG0004	ammonium transporteR
I6I50_08910	COG3622	Belongs to the hyi family
I6I50_08915	COG2084	Dehydrogenase
I6I50_08920	COG1024	Enoyl-CoA hydratase
I6I50_08925	COG2205	protein histidine kinase activity
I6I50_08925	COG5002	protein histidine kinase activity
I6I50_08925	COG0784	Response regulator, receiver
I6I50_08930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I50_08945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I50_08955	COG3956	TIGRFAM MazG family protein
I6I50_08960	COG1555	photosystem II stabilization
I6I50_08965	COG0617	tRNA 3'-terminal CCA addition
I6I50_08970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I50_08980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I50_08985	COG1660	Displays ATPase and GTPase activities
I6I50_08995	COG3028	Belongs to the UPF0307 family
I6I50_09000	COG0318	PFAM AMP-dependent synthetase and ligase
I6I50_09020	COG0625	glutathione transferase activity
I6I50_09030	COG1238	metal cluster binding
I6I50_09075	COG0072	phenylalanine-tRNA ligase activity
I6I50_09100	COG0248	Ppx GppA phosphatase
I6I50_09110	COG0037	tRNA processing
I6I50_09125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I50_09125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I50_09155	COG1764	response to oxidative stress
I6I50_09160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I50_09170	COG2208	phosphoserine phosphatase activity
I6I50_09175	COG2853	Lipoprotein
I6I50_09205	COG2814	Major facilitator Superfamily
I6I50_09235	COG0693	protein deglycase activity
I6I50_09260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I50_09270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I50_09320	COG0494	nUDIX hydrolase
I6I50_09325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I50_09330	COG1214	PFAM Peptidase M22, glycoprotease
I6I50_09335	COG1968	undecaprenyl-diphosphatase activity
I6I50_09370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I50_09380	COG2132	Multicopper oxidase
I6I50_09415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I50_09415	COG0352	thiamine-phosphate diphosphorylase activity
I6I50_09415	COG0351	phosphomethylpyrimidine kinase
I6I50_09445	COG0251	oxidation-reduction process
I6I50_09450	COG1113	amino acid transport
I6I50_09460	COG1981	membrane
I6I50_09475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I50_09490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I50_09500	COG0456	acetyltransferase
I6I50_09510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I50_09515	COG0492	ferredoxin-NADP+ reductase activity
I6I50_09520	COG1674	ftsk spoiiie
I6I50_09520	COG0531	amino acid
I6I50_09535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I50_09540	COG2894	cell division
I6I50_09545	COG0850	regulation of cytokinetic process
I6I50_09555	COG0204	Acyl-transferase
I6I50_09560	COG2885	chlorophyll binding
I6I50_09565	COG0210	DNA helicase
I6I50_09570	COG0756	dUTP diphosphatase activity
I6I50_09585	COG0121	glutamine amidotransferase
I6I50_09600	COG2914	Belongs to the UPF0125 (RnfH) family
I6I50_09605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I50_09610	COG0735	belongs to the Fur family
I6I50_09640	COG0420	3'-5' exonuclease activity
I6I50_09645	COG3706	GGDEF domain
I6I50_09645	COG4251	negative regulation of phosphorylation
I6I50_09645	COG2203	Gaf domain
I6I50_09645	COG5001	Diguanylate cyclase
I6I50_09655	COG1090	epimerase
I6I50_09670	COG2050	protein possibly involved in aromatic compounds catabolism
I6I50_09675	COG1566	PFAM secretion protein HlyD family protein
I6I50_09680	COG2814	Major facilitator Superfamily
I6I50_09685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I50_09695	COG0582	viral genome integration into host DNA
I6I50_09700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I50_09715	COG0531	amino acid
I6I50_09735	COG3152	Membrane
I6I50_09755	COG1401	restriction endodeoxyribonuclease activity
I6I50_09755	COG1401	restriction endodeoxyribonuclease activity
I6I50_09790	COG3177	Filamentation induced by cAMP protein fic
I6I50_09815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I50_09820	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I50_09825	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I50_09830	COG2205	protein histidine kinase activity
I6I50_09835	COG0745	RESPONSE REGULATOR receiver
I6I50_09840	COG0697	spore germination
I6I50_09845	COG2721	sulfolactate sulfo-lyase activity
I6I50_09850	COG2271	Major facilitator Superfamily
I6I50_09860	COG1012	belongs to the aldehyde dehydrogenase family
I6I50_09870	COG2186	Transcriptional regulator
I6I50_09880	COG1802	Transcriptional regulator
I6I50_09940	COG0583	DNA-binding transcription factor activity
I6I50_09950	COG1522	sequence-specific DNA binding
I6I50_09960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I50_09980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I50_09990	COG1294	oxidase, subunit
I6I50_09995	COG1271	oxidase subunit
I6I50_10010	COG4772	TonB-dependent receptor
I6I50_10015	COG1113	amino acid transport
I6I50_10025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I50_10030	COG1012	belongs to the aldehyde dehydrogenase family
I6I50_10040	COG1522	sequence-specific DNA binding
I6I50_10045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I50_10055	COG3138	arginine N-succinyltransferase
I6I50_10060	COG1012	belongs to the aldehyde dehydrogenase family
I6I50_10065	COG3724	N-succinylarginine dihydrolase activity
I6I50_10075	COG1113	amino acid transport
I6I50_10100	COG4772	TonB-dependent receptor
I6I50_10110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I50_10120	COG0583	DNA-binding transcription factor activity
I6I50_10125	COG2610	gluconate transmembrane transporter activity
I6I50_10130	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_10135	COG3293	Transposase
I6I50_10145	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I50_10190	COG3293	Transposase
I6I50_10200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I50_10210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I50_10215	COG1077	Cell shape determining protein MreB Mrl
I6I50_10220	COG1792	Involved in formation and maintenance of cell shape
I6I50_10225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I50_10230	COG0424	maF-like protein
I6I50_10245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I50_10300	COG0640	Transcriptional regulator
I6I50_10310	COG0798	PFAM Bile acid sodium symporter
I6I50_10315	COG0431	NADPH-dependent FMN reductase
I6I50_10320	COG2072	flavoprotein involved in K transport
I6I50_10330	COG0625	glutathione transferase activity
I6I50_10350	COG1113	amino acid transport
I6I50_10365	COG3293	Transposase
I6I50_10370	COG1113	amino acid transport
I6I50_10375	COG2828	Protein conserved in bacteria
I6I50_10380	COG0142	geranyltranstransferase activity
I6I50_10400	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I50_10420	COG2194	sulfuric ester hydrolase activity
I6I50_10425	COG0745	RESPONSE REGULATOR receiver
I6I50_10430	COG0642	Histidine kinase
I6I50_10445	COG0004	ammonium transporteR
I6I50_10455	COG1126	abc transporter atp-binding protein
I6I50_10460	COG0765	amino acid transport
I6I50_10465	COG0765	amino acid transport
I6I50_10485	COG0668	transmembrane transport
I6I50_10500	COG2081	HI0933 family
I6I50_10505	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I50_10540	COG4716	Myosin-crossreactive antigen
I6I50_10565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I50_10575	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_10580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I50_10580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I50_10600	COG0489	protein tyrosine kinase activity
I6I50_10615	COG2358	TRAP transporter, solute receptor (TAXI family
I6I50_10660	COG1566	PFAM secretion protein HlyD family protein
I6I50_10685	COG0840	transmembrane signaling receptor activity
I6I50_10690	COG0643	Histidine kinase
I6I50_10690	COG2198	Histidine kinase
I6I50_10690	COG0784	Response regulator, receiver
I6I50_10700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I50_10715	COG2832	Protein of unknown function (DUF454)
I6I50_10785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I50_10795	COG1289	transmembrane transporter activity
I6I50_10800	COG2814	Major facilitator Superfamily
I6I50_10815	COG0786	glutamate:sodium symporter activity
I6I50_10820	COG1115	amino acid carrier protein
I6I50_10835	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I50_10840	COG1607	acyl-coa hydrolase
I6I50_10850	COG0523	cobalamin synthesis protein
I6I50_10855	COG4681	YaeQ
I6I50_10865	COG2203	Gaf domain
I6I50_10865	COG2199	diguanylate cyclase activity
I6I50_10870	COG0456	acetyltransferase
I6I50_10920	COG0477	Major facilitator Superfamily
I6I50_10925	COG0242	peptide deformylase activity
I6I50_10930	COG2207	Transcriptional regulator
I6I50_10935	COG2223	nitrite transmembrane transporter activity
I6I50_10955	COG0515	serine threonine protein kinase
I6I50_10955	COG2815	serine threonine protein kinase
I6I50_10965	COG0306	phosphate transporter
I6I50_11010	COG4181	ATPase activity
I6I50_11015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I50_11035	COG0583	DNA-binding transcription factor activity
I6I50_11045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I50_11050	COG1773	rubredoxin
I6I50_11055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I50_11085	COG0210	DNA helicase
I6I50_11095	COG1695	Transcriptional regulator
I6I50_11110	COG4221	oxidoreductase activity
I6I50_11110	COG0604	alcohol dehydrogenase
I6I50_11110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I50_11110	COG3321	synthase
I6I50_11135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I50_11150	COG0477	Major facilitator Superfamily
I6I50_11165	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I50_11170	COG1597	lipid kinase activity
I6I50_11190	COG0641	radical SAM
I6I50_11195	COG3119	arylsulfatase activity
I6I50_11220	COG0742	ribosomal rna small subunit methyltransferase
I6I50_11225	COG0768	penicillin binding
I6I50_11250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I50_11255	COG2878	Part of a membrane complex involved in electron transport
I6I50_11260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I50_11270	COG3384	dioxygenase
I6I50_11280	COG2234	aminopeptidase activity
I6I50_11295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I50_11305	COG2217	Heavy metal translocating P-type atpase
I6I50_11315	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I50_11335	COG4770	biotin carboxylase activity
I6I50_11360	COG0006	proline dipeptidase activity
I6I50_11370	COG2801	Transposase and inactivated derivatives
I6I50_11375	COG2801	Transposase and inactivated derivatives
I6I50_11385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I50_11390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I50_11410	COG2915	High frequency lysogenization protein hflD homolog
I6I50_11430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I50_11435	COG1686	Belongs to the peptidase S11 family
I6I50_11450	COG0789	Transcriptional regulator
I6I50_11465	COG0753	catalase activity
I6I50_11500	COG0583	DNA-binding transcription factor activity
I6I50_11520	COG0657	acetylesterase activity
I6I50_11535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I50_11540	COG1388	LysM domain
I6I50_11540	COG0741	lytic transglycosylase activity
I6I50_11545	COG4166	transmembrane transport
I6I50_11550	COG4174	ABC transporter (Permease)
I6I50_11555	COG4239	(ABC) transporter, permease
I6I50_11560	COG4172	Belongs to the ABC transporter superfamily
I6I50_11575	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I50_11600	COG0833	amino acid
I6I50_11625	COG0833	amino acid
I6I50_11635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I50_11640	COG0418	dihydroorotase activity
I6I50_11645	COG5001	Diguanylate cyclase
I6I50_11645	COG4251	negative regulation of phosphorylation
I6I50_11645	COG2203	Gaf domain
I6I50_11645	COG3706	GGDEF domain
I6I50_11660	COG2186	Transcriptional regulator
I6I50_11670	COG0277	FAD linked oxidase domain protein
I6I50_11705	COG0280	phosphate acetyltransferase
I6I50_11705	COG0281	malic enzyme
I6I50_11710	COG5001	Diguanylate cyclase
I6I50_11710	COG1716	ATPase activity
I6I50_11715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I50_11720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I50_11725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I50_11765	COG1960	acyl-CoA dehydrogenase activity
I6I50_11770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I50_11775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I50_11790	COG1671	Belongs to the UPF0178 family
I6I50_11805	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I50_11810	COG1136	(ABC) transporter
I6I50_11815	COG2333	competence protein COMEC
I6I50_11815	COG0658	competence protein
I6I50_11835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I50_11840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I50_11845	COG0628	permease
I6I50_11850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I50_11880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I50_11900	COG0823	Involved in the tonB-independent uptake of proteins
I6I50_11920	COG0824	Thioesterase
I6I50_11935	COG2255	four-way junction helicase activity
I6I50_11950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I50_11950	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I50_11960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I50_11960	COG3323	Protein of unknown function (DUF1653)
I6I50_11965	COG0778	Nitroreductase
I6I50_11970	COG1024	Enoyl-CoA hydratase
I6I50_11975	COG1051	belongs to the nudix hydrolase family
I6I50_11975	COG1056	cytidyltransferase-related domain
I6I50_11980	COG2353	YceI-like domain
I6I50_11985	COG0583	DNA-binding transcription factor activity
I6I50_11995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I50_12010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I50_12015	COG0602	queuosine metabolic process
I6I50_12035	COG0583	DNA-binding transcription factor activity
I6I50_12040	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I50_12045	COG4208	sulfate ABC transporter
I6I50_12060	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I50_12070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I50_12090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I50_12425	COG3772	lysozyme
I6I50_12435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I50_12470	COG0681	Belongs to the peptidase S26 family
I6I50_12485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I50_12495	COG1381	Involved in DNA repair and RecF pathway recombination
I6I50_12500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I50_12535	COG0436	Aminotransferase
I6I50_12545	COG2199	diguanylate cyclase activity
I6I50_12560	COG0556	nucleotide-excision repair
I6I50_12590	COG0702	epimerase
I6I50_12595	COG1733	regulation of RNA biosynthetic process
I6I50_12605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I50_12610	COG0671	phosphoesterase, PA-phosphatase related
I6I50_12625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I50_12630	COG0076	glutamate decarboxylase activity
I6I50_12635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I50_12640	COG0573	inorganic phosphate transmembrane transporter activity
I6I50_12650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I50_12655	COG0616	signal peptide processing
I6I50_12660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I50_12665	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I50_12670	COG1067	ATP-dependent peptidase activity
I6I50_12695	COG0254	rRNA binding
I6I50_12715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I50_12720	COG1966	Carbon starvation protein
I6I50_12725	COG2879	small protein
I6I50_12730	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I50_12735	COG0714	Associated with various cellular activities
I6I50_12785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I50_12790	COG4197	protein conserved in bacteria, prophage-related
I6I50_12830	COG4220	transposase activity
I6I50_12950	COG4680	protein conserved in bacteria
I6I50_12960	COG3093	addiction module antidote protein HigA
I6I50_13040	COG2826	transposase and inactivated derivatives, IS30 family
I6I50_13055	COG3081	Nucleoid-associated protein
I6I50_13205	COG4695	Portal protein
I6I50_13235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I50_13240	COG3646	Phage regulatory protein
I6I50_13300	COG1131	(ABC) transporter
I6I50_13305	COG0842	Transport permease protein
I6I50_13310	COG0842	Transport permease protein
I6I50_13335	COG1309	transcriptional regulator
I6I50_13410	COG1733	regulation of RNA biosynthetic process
I6I50_13415	COG0604	alcohol dehydrogenase
I6I50_13430	COG1278	Cold shock
I6I50_13465	COG2070	2-Nitropropane dioxygenase
I6I50_13490	COG3634	alkyl hydroperoxide reductase activity
I6I50_13510	COG0436	Aminotransferase
I6I50_13515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I50_13520	COG0386	Belongs to the glutathione peroxidase family
I6I50_13545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I50_13560	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I50_13585	COG0012	GTP binding
I6I50_13600	COG2011	ABC-type metal ion transport system permease component
I6I50_13605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I50_13610	COG1464	Belongs to the NlpA lipoprotein family
I6I50_13615	COG1464	Belongs to the NlpA lipoprotein family
I6I50_13660	COG3293	Transposase
I6I50_13670	COG0582	viral genome integration into host DNA
I6I50_13775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I50_13780	COG0730	response to heat
I6I50_13800	COG4773	Receptor
I6I50_13805	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I50_13810	COG1944	ATP diphosphatase activity
I6I50_13815	COG2207	Transcriptional regulator
I6I50_13820	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I50_13825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I50_13855	COG2223	nitrite transmembrane transporter activity
I6I50_13870	COG1346	cytolysis
I6I50_13875	COG1380	Effector of murein hydrolase LrgA
I6I50_13880	COG0583	DNA-binding transcription factor activity
I6I50_13885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I50_13915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I50_13985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I50_13990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I50_14005	COG5001	Diguanylate cyclase
I6I50_14005	COG3300	MHYT domain
I6I50_14010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I50_14020	COG2814	Major facilitator Superfamily
I6I50_14035	COG1132	(ABC) transporter
I6I50_14045	COG0668	transmembrane transport
I6I50_14050	COG3122	Protein conserved in bacteria
I6I50_14070	COG0640	Transcriptional regulator
I6I50_14075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I50_14085	COG0183	Belongs to the thiolase family
I6I50_14090	COG0583	DNA-binding transcription factor activity
I6I50_14105	COG0439	Biotin carboxylase
I6I50_14120	COG0511	ligase activity, forming carbon-carbon bonds
I6I50_14130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I50_14135	COG0183	Belongs to the thiolase family
I6I50_14140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I50_14145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I50_14150	COG3135	benzoate transporter
I6I50_14155	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_14160	COG0543	2 iron, 2 sulfur cluster binding
I6I50_14160	COG0633	Ferredoxin
I6I50_14165	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I50_14170	COG4638	Rieske (2fe-2S)
I6I50_14180	COG4829	muconolactone delta-isomerase
I6I50_14185	COG4948	Mandelate Racemase Muconate Lactonizing
I6I50_14190	COG0583	DNA-binding transcription factor activity
I6I50_14195	COG2814	Major facilitator Superfamily
I6I50_14290	COG0583	DNA-binding transcription factor activity
I6I50_14305	COG1309	transcriptional regulator
I6I50_14310	COG0604	alcohol dehydrogenase
I6I50_14365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I50_14370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I50_14375	COG0022	dehydrogenase e1 component
I6I50_14380	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I50_14395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I50_14405	COG1063	alcohol dehydrogenase
I6I50_14410	COG4628	conserved protein (DUF2132)
I6I50_14490	COG3293	Transposase
I6I50_14660	COG0596	Alpha beta hydrolase
I6I50_14730	COG0864	Transcriptional regulator
I6I50_14760	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_14765	COG2814	Major facilitator Superfamily
I6I50_14775	COG2199	diguanylate cyclase activity
I6I50_14820	COG1960	acyl-CoA dehydrogenase activity
I6I50_14825	COG1960	acyl-CoA dehydrogenase activity
I6I50_14865	COG3293	Transposase
I6I50_14885	COG0552	protein localization to endoplasmic reticulum
I6I50_14890	COG0612	Peptidase, M16
I6I50_14915	COG0517	IMP dehydrogenase activity
I6I50_14915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I50_14920	COG0133	tryptophan synthase activity
I6I50_14930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I50_14945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I50_14950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I50_14995	COG0537	adenosine 5'-monophosphoramidase activity
I6I50_15020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I50_15025	COG0776	regulation of translation
I6I50_15040	COG1959	2 iron, 2 sulfur cluster binding
I6I50_15050	COG0822	iron-sulfur transferase activity
I6I50_15055	COG0316	Belongs to the HesB IscA family
I6I50_15085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I50_15100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I50_15115	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I50_15115	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I50_15115	COG0506	proline dehydrogenase activity
I6I50_15145	COG3781	membrane
I6I50_15150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I50_15175	COG0697	spore germination
I6I50_15190	COG0126	phosphoglycerate kinase activity
I6I50_15200	COG0424	maF-like protein
I6I50_15210	COG2850	peptidyl-arginine hydroxylation
I6I50_15215	COG4585	Histidine kinase
I6I50_15220	COG2197	response regulator
I6I50_15225	COG0069	glutamate synthase activity
I6I50_15245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I50_15255	COG0824	Thioesterase
I6I50_15260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I50_15290	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_15295	COG0183	Belongs to the thiolase family
I6I50_15310	COG0583	DNA-binding transcription factor activity
I6I50_15315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I50_15325	COG3135	benzoate transporter
I6I50_15330	COG1309	transcriptional regulator
I6I50_15335	COG2076	Multidrug Resistance protein
I6I50_15350	COG0589	response to stress
I6I50_15360	COG0308	aminopeptidase N
I6I50_15385	COG1253	flavin adenine dinucleotide binding
I6I50_15405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I50_15410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I50_15425	COG2431	L-lysine efflux transmembrane transporter activity
I6I50_15440	COG0776	regulation of translation
I6I50_15460	COG0590	tRNA wobble adenosine to inosine editing
I6I50_15470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I50_15505	COG0084	hydrolase, TatD family'
I6I50_15525	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I50_15530	COG1132	(ABC) transporter
I6I50_15540	COG0811	peptide transport
I6I50_15545	COG1475	DNA binding
I6I50_15550	COG1192	Involved in chromosome partitioning
I6I50_15560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I50_15565	COG3178	'Phosphotransferase
I6I50_15575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I50_15580	COG1923	regulation of RNA biosynthetic process
I6I50_15590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I50_15595	COG0802	atpase or kinase
I6I50_15600	COG0564	pseudouridine synthase activity
I6I50_15615	COG1187	pseudouridine synthase activity
I6I50_15620	COG2707	UPF0756 membrane protein
I6I50_15625	COG2814	Major facilitator Superfamily
I6I50_15630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I50_15635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I50_15645	COG1454	alcohol dehydrogenase
I6I50_15665	COG0531	amino acid
I6I50_15675	COG4303	Ethanolamine ammonia lyase large subunit
I6I50_15680	COG4302	ethanolamine ammonia-lyase activity
I6I50_15690	COG1028	Short-chain dehydrogenase reductase Sdr
I6I50_15700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I50_15700	COG0519	Catalyzes the synthesis of GMP from XMP
I6I50_15705	COG2353	YceI-like domain
I6I50_15710	COG0456	acetyltransferase
I6I50_15720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I50_15725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I50_15770	COG0352	thiamine-phosphate diphosphorylase activity
I6I50_15805	COG0612	Peptidase, M16
I6I50_15820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I50_15890	COG1570	exodeoxyribonuclease VII activity
I6I50_15905	COG1877	trehalose-phosphatase activity
I6I50_15910	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I50_15915	COG2223	nitrite transmembrane transporter activity
I6I50_15970	COG2323	membrane
I6I50_15990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I50_16020	COG3293	Transposase
I6I50_16130	COG2351	hydroxyisourate hydrolase activity
I6I50_16140	COG1686	Belongs to the peptidase S11 family
I6I50_16145	COG1252	NADH dehydrogenase
I6I50_16150	COG1047	Peptidyl-prolyl cis-trans
I6I50_16155	COG1254	Belongs to the acylphosphatase family
I6I50_16160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I50_16160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I50_16180	COG0318	PFAM AMP-dependent synthetase and ligase
I6I50_16185	COG2819	hydrolase of the alpha beta superfamily
I6I50_16195	COG0372	Belongs to the citrate synthase family
I6I50_16215	COG3293	Transposase
I6I50_16230	COG0542	response to heat
I6I50_16235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I50_16250	COG3706	GGDEF domain
I6I50_16260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I50_16265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I50_16270	COG3385	transposase activity
I6I50_16280	COG0569	domain protein
I6I50_16285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I50_16305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I50_16315	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I50_16330	COG1294	oxidase, subunit
I6I50_16335	COG4890	Cyd operon protein YbgT
I6I50_16350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I50_16355	COG1309	transcriptional regulator
I6I50_16360	COG1012	belongs to the aldehyde dehydrogenase family
I6I50_16370	COG0579	oxidoreductase
I6I50_16385	COG0772	Belongs to the SEDS family
I6I50_16400	COG0148	phosphopyruvate hydratase activity
I6I50_16420	COG0583	DNA-binding transcription factor activity
I6I50_16430	COG2814	Major facilitator Superfamily
I6I50_16445	COG1902	pentaerythritol trinitrate reductase activity
I6I50_16445	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I50_16465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I50_16470	COG0702	epimerase
I6I50_16515	COG1011	Hydrolase
I6I50_16520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I50_16525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I50_16530	COG2137	regulation of response to DNA damage stimulus
I6I50_16545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I50_16565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I50_16580	COG0575	Belongs to the CDS family
I6I50_16585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I50_16605	COG3852	Histidine kinase
I6I50_16625	COG0583	DNA-binding transcription factor activity
I6I50_16630	COG0024	Methionine aminopeptidase
I6I50_16655	COG1113	amino acid transport
I6I50_16665	COG0786	glutamate:sodium symporter activity
I6I50_16670	COG4773	Receptor
I6I50_16715	COG0729	surface antigen
I6I50_16740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I50_16755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I50_16760	COG1960	acyl-CoA dehydrogenase activity
I6I50_16790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I50_16795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I50_16800	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I50_16805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I50_16820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I50_16855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I50_16860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I50_16865	COG1845	cytochrome c oxidase, subunit III
I6I50_16870	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I50_16890	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I50_16905	COG0305	Participates in initiation and elongation during chromosome replication
I6I50_16910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I50_16925	COG1305	Transglutaminase-like
I6I50_16935	COG2308	Evidence 4 Homologs of previously reported genes of
I6I50_16950	COG0445	tRNA wobble uridine modification
I6I50_16980	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I50_16985	COG0138	bifunctional purine biosynthesis protein purh
I6I50_16990	COG0151	Belongs to the GarS family
I6I50_17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I50_17010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I50_17015	COG2011	ABC-type metal ion transport system permease component
I6I50_17055	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I50_17065	COG3293	Transposase
I6I50_17070	COG4122	O-methyltransferase activity
I6I50_17090	COG1137	ATPase activity
I6I50_17095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I50_17105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I50_17110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I50_17110	COG0517	IMP dehydrogenase activity
I6I50_17120	COG0406	alpha-ribazole phosphatase activity
I6I50_17125	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I50_17160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I50_17170	COG0243	molybdopterin cofactor binding
I6I50_17175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I50_17180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I50_17185	COG2223	nitrite transmembrane transporter activity
I6I50_17195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I50_17195	COG1116	anion transmembrane transporter activity
I6I50_17215	COG1643	Atp-dependent helicase
I6I50_17225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I50_17265	COG0515	serine threonine protein kinase
I6I50_17265	COG2815	serine threonine protein kinase
I6I50_17295	COG1610	YqeY-like protein
I6I50_17300	COG4783	chaperone-mediated protein folding
I6I50_17330	COG0167	dihydroorotate dehydrogenase activity
I6I50_17355	COG0778	Nitroreductase
I6I50_17365	COG0513	Belongs to the DEAD box helicase family
I6I50_17370	COG1278	Cold shock
I6I50_17385	COG2363	Small membrane protein
I6I50_17410	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I50_17415	COG0625	glutathione transferase activity
I6I50_17420	COG0659	secondary active sulfate transmembrane transporter activity
I6I50_17430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I50_17460	COG0318	PFAM AMP-dependent synthetase and ligase
I6I50_17465	COG1309	transcriptional regulator
I6I50_17470	COG1960	acyl-CoA dehydrogenase activity
I6I50_17475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I50_17485	COG4770	biotin carboxylase activity
I6I50_17500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I50_17505	COG2031	fatty acid transporter
I6I50_17525	COG0540	Belongs to the ATCase OTCase family
I6I50_17545	COG0542	response to heat
I6I50_17550	COG1765	OsmC-like protein
I6I50_17560	COG0667	Aldo Keto reductase
I6I50_17575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I50_17590	COG1522	sequence-specific DNA binding
I6I50_17595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I50_17610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I50_17620	COG0527	aspartate kinase activity
I6I50_17635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I50_17670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I50_17725	COG0659	secondary active sulfate transmembrane transporter activity
I6I50_17730	COG0589	response to stress
I6I50_17825	COG2814	Major facilitator Superfamily
I6I50_17955	COG0604	alcohol dehydrogenase
I6I50_17975	COG1063	alcohol dehydrogenase
I6I50_17990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I50_17995	COG2801	Transposase and inactivated derivatives
I6I50_18065	COG0515	serine threonine protein kinase
I6I50_18070	COG2116	formate transmembrane transporter activity
I6I50_18100	COG1192	Involved in chromosome partitioning
I6I50_18105	COG1475	DNA binding
I6I50_18125	COG2814	Major facilitator Superfamily
I6I50_18130	COG0583	DNA-binding transcription factor activity
I6I50_18140	COG2026	Addiction module toxin, RelE StbE family
I6I50_18145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I50_18175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I50_18200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I50_18205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I50_18270	COG0789	Transcriptional regulator
I6I50_18320	COG2217	Heavy metal translocating P-type atpase
I6I50_18330	COG4372	Transposase
I6I50_18345	COG2205	protein histidine kinase activity
I6I50_18360	COG2132	Multicopper oxidase
I6I50_18395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I50_18410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I50_18420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I50_18455	COG0625	glutathione transferase activity
I6I50_18460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I50_18530	COG4680	protein conserved in bacteria
I6I50_18535	COG1373	ATPase (AAA superfamily
I6I50_18545	COG0582	viral genome integration into host DNA
I6I50_18590	COG0251	oxidation-reduction process
I6I50_18615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I50_18620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I50_18625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I50_18630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I50_18635	COG1917	Cupin 2, conserved barrel domain protein
I6I50_18635	COG4977	sequence-specific DNA binding
I6I50_18695	COG2801	Transposase and inactivated derivatives
I6I50_18710	COG1764	response to oxidative stress
I6I50_18715	COG1846	Transcriptional regulator
I6I50_18730	COG3842	ATPase activity
I6I50_18735	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I50_18750	COG3335	DDE superfamily endonuclease
I6I50_18780	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I50_18800	COG0604	alcohol dehydrogenase