locus-tag	class	description
I6I51_00015	COG4372	Transposase
I6I51_00030	COG2132	Multicopper oxidase
I6I51_00045	COG2205	protein histidine kinase activity
I6I51_00065	COG4372	Transposase
I6I51_00075	COG2217	Heavy metal translocating P-type atpase
I6I51_00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I51_00150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I51_00175	COG1192	Involved in chromosome partitioning
I6I51_00295	COG0589	response to stress
I6I51_00300	COG0659	secondary active sulfate transmembrane transporter activity
I6I51_00355	COG0842	Transport permease protein
I6I51_00360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_00375	COG2175	clavaminate synthase activity
I6I51_00395	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I51_00430	COG2951	lytic endotransglycosylase activity
I6I51_00445	COG0842	Transport permease protein
I6I51_00450	COG1131	(ABC) transporter
I6I51_00460	COG0303	'Molybdopterin
I6I51_00465	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I51_00465	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I51_00480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I51_00490	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I51_00495	COG4149	molybdate abc transporter
I6I51_00520	COG0235	Class ii aldolase
I6I51_00530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I51_00540	COG3293	Transposase
I6I51_00545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I51_00545	COG0475	glutathione-regulated potassium exporter activity
I6I51_00550	COG3706	GGDEF domain
I6I51_00615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I51_00640	COG3634	alkyl hydroperoxide reductase activity
I6I51_00645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I51_00650	COG0826	peptidase U32
I6I51_00685	COG1720	tRNA m6t6A37 methyltransferase activity
I6I51_00705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I51_00720	COG0642	Histidine kinase
I6I51_00730	COG0494	nUDIX hydrolase
I6I51_00740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I51_00745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I51_00750	COG3139	Protein of unknown function (DUF1315)
I6I51_00760	COG1301	dicarboxylic acid transport
I6I51_00770	COG0693	protein deglycase activity
I6I51_00780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I51_00785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I51_00835	COG0415	Belongs to the DNA photolyase family
I6I51_00845	COG2252	PERMEase
I6I51_00850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I51_00860	COG3038	cytochrome b561
I6I51_00875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I51_00885	COG0527	aspartate kinase activity
I6I51_00890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I51_00895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I51_00910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I51_00915	COG1522	sequence-specific DNA binding
I6I51_00930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I51_00945	COG0667	Aldo Keto reductase
I6I51_00955	COG1765	OsmC-like protein
I6I51_00980	COG0540	Belongs to the ATCase OTCase family
I6I51_01045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I51_01055	COG0659	secondary active sulfate transmembrane transporter activity
I6I51_01060	COG0625	glutathione transferase activity
I6I51_01065	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I51_01090	COG2363	Small membrane protein
I6I51_01105	COG1278	Cold shock
I6I51_01110	COG0513	Belongs to the DEAD box helicase family
I6I51_01120	COG0778	Nitroreductase
I6I51_01175	COG4783	chaperone-mediated protein folding
I6I51_01180	COG1610	YqeY-like protein
I6I51_01210	COG2815	serine threonine protein kinase
I6I51_01210	COG0515	serine threonine protein kinase
I6I51_01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I51_01260	COG1643	Atp-dependent helicase
I6I51_01280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I51_01280	COG1116	anion transmembrane transporter activity
I6I51_01295	COG2223	nitrite transmembrane transporter activity
I6I51_01300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_01305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_01310	COG0243	molybdopterin cofactor binding
I6I51_01320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I51_01355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I51_01360	COG0406	alpha-ribazole phosphatase activity
I6I51_01370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I51_01370	COG0517	IMP dehydrogenase activity
I6I51_01375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I51_01385	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I51_01390	COG1137	ATPase activity
I6I51_01410	COG4122	O-methyltransferase activity
I6I51_01420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I51_01465	COG2011	ABC-type metal ion transport system permease component
I6I51_01470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I51_01490	COG0151	Belongs to the GarS family
I6I51_01495	COG0138	bifunctional purine biosynthesis protein purh
I6I51_01500	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I51_01530	COG0445	tRNA wobble uridine modification
I6I51_01545	COG2308	Evidence 4 Homologs of previously reported genes of
I6I51_01555	COG1305	Transglutaminase-like
I6I51_01570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I51_01575	COG0305	Participates in initiation and elongation during chromosome replication
I6I51_01590	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I51_01610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I51_01615	COG1845	cytochrome c oxidase, subunit III
I6I51_01620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I51_01625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I51_01655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I51_01670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I51_01675	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I51_01680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I51_01685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I51_01720	COG1960	acyl-CoA dehydrogenase activity
I6I51_01725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I51_01740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I51_01765	COG0729	surface antigen
I6I51_01815	COG1113	amino acid transport
I6I51_01840	COG0024	Methionine aminopeptidase
I6I51_01845	COG0583	DNA-binding transcription factor activity
I6I51_01850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I51_01865	COG3852	Histidine kinase
I6I51_01885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I51_01890	COG0575	Belongs to the CDS family
I6I51_01905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I51_01925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I51_01940	COG2137	regulation of response to DNA damage stimulus
I6I51_01945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I51_01950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I51_01955	COG1011	Hydrolase
I6I51_01990	COG3293	Transposase
I6I51_02005	COG0702	epimerase
I6I51_02010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I51_02060	COG2814	Major facilitator Superfamily
I6I51_02070	COG0583	DNA-binding transcription factor activity
I6I51_02090	COG0148	phosphopyruvate hydratase activity
I6I51_02105	COG0772	Belongs to the SEDS family
I6I51_02120	COG0579	oxidoreductase
I6I51_02130	COG1012	belongs to the aldehyde dehydrogenase family
I6I51_02135	COG1309	transcriptional regulator
I6I51_02140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I51_02155	COG4890	Cyd operon protein YbgT
I6I51_02160	COG1294	oxidase, subunit
I6I51_02175	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I51_02185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I51_02205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I51_02210	COG0569	domain protein
I6I51_02220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I51_02225	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I51_02250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I51_02255	COG0542	response to heat
I6I51_02285	COG0372	Belongs to the citrate synthase family
I6I51_02315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I51_02320	COG0730	response to heat
I6I51_02335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I51_02340	COG1944	ATP diphosphatase activity
I6I51_02350	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I51_02355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I51_02390	COG2223	nitrite transmembrane transporter activity
I6I51_02405	COG1346	cytolysis
I6I51_02410	COG1380	Effector of murein hydrolase LrgA
I6I51_02415	COG0583	DNA-binding transcription factor activity
I6I51_02420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I51_02450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I51_02470	COG1960	acyl-CoA dehydrogenase activity
I6I51_02485	COG1960	acyl-CoA dehydrogenase activity
I6I51_02525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I51_02530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I51_02545	COG5001	Diguanylate cyclase
I6I51_02545	COG3300	MHYT domain
I6I51_02555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I51_02565	COG2814	Major facilitator Superfamily
I6I51_02580	COG1132	(ABC) transporter
I6I51_02595	COG0668	transmembrane transport
I6I51_02605	COG3122	Protein conserved in bacteria
I6I51_02625	COG0640	Transcriptional regulator
I6I51_02630	COG0596	Alpha beta hydrolase
I6I51_02640	COG1335	isochorismatase
I6I51_02645	COG0251	oxidation-reduction process
I6I51_02650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_02655	COG2233	PERMEase
I6I51_02665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I51_02675	COG0183	Belongs to the thiolase family
I6I51_02680	COG0583	DNA-binding transcription factor activity
I6I51_02695	COG0439	Biotin carboxylase
I6I51_02710	COG0511	ligase activity, forming carbon-carbon bonds
I6I51_02720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I51_02725	COG0183	Belongs to the thiolase family
I6I51_02730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I51_02735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I51_02740	COG3135	benzoate transporter
I6I51_02745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_02750	COG0543	2 iron, 2 sulfur cluster binding
I6I51_02750	COG0633	Ferredoxin
I6I51_02755	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I51_02760	COG4638	Rieske (2fe-2S)
I6I51_02770	COG4829	muconolactone delta-isomerase
I6I51_02775	COG4948	Mandelate Racemase Muconate Lactonizing
I6I51_02780	COG0583	DNA-binding transcription factor activity
I6I51_02785	COG2814	Major facilitator Superfamily
I6I51_02880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I51_02885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I51_02890	COG0022	dehydrogenase e1 component
I6I51_02895	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I51_02900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I51_02910	COG1063	alcohol dehydrogenase
I6I51_03010	COG4372	Transposase
I6I51_03165	COG2801	Transposase and inactivated derivatives
I6I51_03270	COG0596	Alpha beta hydrolase
I6I51_03340	COG0864	Transcriptional regulator
I6I51_03365	COG2814	Major facilitator Superfamily
I6I51_03420	COG1960	acyl-CoA dehydrogenase activity
I6I51_03425	COG1960	acyl-CoA dehydrogenase activity
I6I51_03485	COG0552	protein localization to endoplasmic reticulum
I6I51_03490	COG0612	Peptidase, M16
I6I51_03515	COG0517	IMP dehydrogenase activity
I6I51_03515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I51_03525	COG0133	tryptophan synthase activity
I6I51_03535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I51_03550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I51_03555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I51_03585	COG0537	adenosine 5'-monophosphoramidase activity
I6I51_03610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I51_03615	COG0776	regulation of translation
I6I51_03630	COG1959	2 iron, 2 sulfur cluster binding
I6I51_03640	COG0822	iron-sulfur transferase activity
I6I51_03645	COG0316	Belongs to the HesB IscA family
I6I51_03675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I51_03685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I51_03695	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I51_03695	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I51_03695	COG0506	proline dehydrogenase activity
I6I51_03725	COG3781	membrane
I6I51_03730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I51_03760	COG0697	spore germination
I6I51_03775	COG0126	phosphoglycerate kinase activity
I6I51_03785	COG0424	maF-like protein
I6I51_03790	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_03795	COG2850	peptidyl-arginine hydroxylation
I6I51_03805	COG2197	response regulator
I6I51_03810	COG0069	glutamate synthase activity
I6I51_03830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I51_03835	COG1454	alcohol dehydrogenase
I6I51_03840	COG0824	Thioesterase
I6I51_03845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I51_03865	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_03870	COG0183	Belongs to the thiolase family
I6I51_03885	COG0583	DNA-binding transcription factor activity
I6I51_03890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I51_03900	COG3135	benzoate transporter
I6I51_03905	COG1309	transcriptional regulator
I6I51_03910	COG2076	Multidrug Resistance protein
I6I51_03925	COG0589	response to stress
I6I51_03935	COG0308	aminopeptidase N
I6I51_03960	COG1253	flavin adenine dinucleotide binding
I6I51_03980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I51_03985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I51_04000	COG2431	L-lysine efflux transmembrane transporter activity
I6I51_04015	COG0776	regulation of translation
I6I51_04035	COG0590	tRNA wobble adenosine to inosine editing
I6I51_04045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I51_04080	COG0084	hydrolase, TatD family'
I6I51_04100	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I51_04105	COG1132	(ABC) transporter
I6I51_04115	COG0811	peptide transport
I6I51_04120	COG1475	DNA binding
I6I51_04125	COG1192	Involved in chromosome partitioning
I6I51_04135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I51_04140	COG3178	'Phosphotransferase
I6I51_04150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I51_04155	COG1923	regulation of RNA biosynthetic process
I6I51_04165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I51_04170	COG0802	atpase or kinase
I6I51_04190	COG1187	pseudouridine synthase activity
I6I51_04195	COG2707	UPF0756 membrane protein
I6I51_04205	COG2814	Major facilitator Superfamily
I6I51_04210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I51_04215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I51_04225	COG1454	alcohol dehydrogenase
I6I51_04245	COG0531	amino acid
I6I51_04250	COG4303	Ethanolamine ammonia lyase large subunit
I6I51_04255	COG4302	ethanolamine ammonia-lyase activity
I6I51_04275	COG0519	Catalyzes the synthesis of GMP from XMP
I6I51_04275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I51_04295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I51_04300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I51_04350	COG0352	thiamine-phosphate diphosphorylase activity
I6I51_04385	COG0612	Peptidase, M16
I6I51_04395	COG1823	symporter activity
I6I51_04400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_04440	COG2351	hydroxyisourate hydrolase activity
I6I51_04450	COG1686	Belongs to the peptidase S11 family
I6I51_04455	COG1252	NADH dehydrogenase
I6I51_04460	COG1047	Peptidyl-prolyl cis-trans
I6I51_04465	COG1254	Belongs to the acylphosphatase family
I6I51_04470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I51_04470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I51_04520	COG4372	Transposase
I6I51_04575	COG1464	Belongs to the NlpA lipoprotein family
I6I51_04580	COG1464	Belongs to the NlpA lipoprotein family
I6I51_04585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I51_04590	COG2011	ABC-type metal ion transport system permease component
I6I51_04595	COG0012	GTP binding
I6I51_04620	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I51_04635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I51_04650	COG0386	Belongs to the glutathione peroxidase family
I6I51_04655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I51_04660	COG0436	Aminotransferase
I6I51_04680	COG3634	alkyl hydroperoxide reductase activity
I6I51_04705	COG2070	2-Nitropropane dioxygenase
I6I51_04740	COG3293	Transposase
I6I51_04780	COG1309	transcriptional regulator
I6I51_04805	COG0842	Transport permease protein
I6I51_04825	COG0783	Belongs to the Dps family
I6I51_04830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I51_04860	COG0745	RESPONSE REGULATOR receiver
I6I51_04865	COG0642	Histidine kinase
I6I51_04880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I51_04925	COG2816	NAD+ diphosphatase activity
I6I51_04930	COG3046	protein related to deoxyribodipyrimidine photolyase
I6I51_04950	COG2351	hydroxyisourate hydrolase activity
I6I51_04985	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_05025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I51_05030	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_05040	COG0582	viral genome integration into host DNA
I6I51_05060	COG0714	Associated with various cellular activities
I6I51_05065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I51_05070	COG2879	small protein
I6I51_05075	COG1966	Carbon starvation protein
I6I51_05080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I51_05100	COG0254	rRNA binding
I6I51_05120	COG1067	ATP-dependent peptidase activity
I6I51_05125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I51_05130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I51_05135	COG0616	signal peptide processing
I6I51_05140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I51_05150	COG0573	inorganic phosphate transmembrane transporter activity
I6I51_05155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I51_05160	COG0076	glutamate decarboxylase activity
I6I51_05165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I51_05180	COG0671	phosphoesterase, PA-phosphatase related
I6I51_05185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I51_05195	COG1733	regulation of RNA biosynthetic process
I6I51_05200	COG0702	epimerase
I6I51_05230	COG0556	nucleotide-excision repair
I6I51_05245	COG2199	diguanylate cyclase activity
I6I51_05255	COG0436	Aminotransferase
I6I51_05295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I51_05300	COG1381	Involved in DNA repair and RecF pathway recombination
I6I51_05310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I51_05315	COG0571	ribonuclease III activity
I6I51_05325	COG0681	Belongs to the peptidase S26 family
I6I51_05340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I51_05360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I51_05370	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I51_05385	COG4208	sulfate ABC transporter
I6I51_05390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I51_05395	COG0583	DNA-binding transcription factor activity
I6I51_05405	COG4625	pathogenesis
I6I51_05415	COG0602	queuosine metabolic process
I6I51_05420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I51_05435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I51_05440	COG1279	arginine transmembrane transporter activity
I6I51_05445	COG0583	DNA-binding transcription factor activity
I6I51_05450	COG2353	YceI-like domain
I6I51_05455	COG1051	belongs to the nudix hydrolase family
I6I51_05455	COG1056	cytidyltransferase-related domain
I6I51_05460	COG1024	Enoyl-CoA hydratase
I6I51_05465	COG0778	Nitroreductase
I6I51_05470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I51_05470	COG3323	Protein of unknown function (DUF1653)
I6I51_05480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I51_05480	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I51_05495	COG2255	four-way junction helicase activity
I6I51_05520	COG0824	Thioesterase
I6I51_05540	COG0823	Involved in the tonB-independent uptake of proteins
I6I51_05560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I51_05590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I51_05595	COG0628	permease
I6I51_05600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I51_05605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I51_05625	COG0658	competence protein
I6I51_05625	COG2333	competence protein COMEC
I6I51_05630	COG1136	(ABC) transporter
I6I51_05635	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I51_05650	COG1671	Belongs to the UPF0178 family
I6I51_05665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I51_05670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I51_05725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I51_05730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I51_05735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I51_05740	COG1716	ATPase activity
I6I51_05740	COG5001	Diguanylate cyclase
I6I51_05745	COG0280	phosphate acetyltransferase
I6I51_05745	COG0281	malic enzyme
I6I51_05775	COG1902	pentaerythritol trinitrate reductase activity
I6I51_05775	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I51_05780	COG0277	FAD linked oxidase domain protein
I6I51_05790	COG2186	Transcriptional regulator
I6I51_05805	COG2203	Gaf domain
I6I51_05805	COG4251	negative regulation of phosphorylation
I6I51_05805	COG5001	Diguanylate cyclase
I6I51_05805	COG3706	GGDEF domain
I6I51_05810	COG0418	dihydroorotase activity
I6I51_05815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I51_05845	COG0833	amino acid
I6I51_05870	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I51_05885	COG4172	Belongs to the ABC transporter superfamily
I6I51_05890	COG4239	(ABC) transporter, permease
I6I51_05895	COG4174	ABC transporter (Permease)
I6I51_05900	COG4166	transmembrane transport
I6I51_05905	COG1388	LysM domain
I6I51_05905	COG0741	lytic transglycosylase activity
I6I51_05910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I51_05925	COG0657	acetylesterase activity
I6I51_05945	COG0583	DNA-binding transcription factor activity
I6I51_05950	COG4942	peptidase
I6I51_05950	COG1388	LysM domain
I6I51_05980	COG0753	catalase activity
I6I51_06005	COG1686	Belongs to the peptidase S11 family
I6I51_06010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I51_06015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I51_06020	COG2267	carboxylic ester hydrolase activity
I6I51_06025	COG2453	phosphatase
I6I51_06025	COG0671	phosphoesterase, PA-phosphatase related
I6I51_06040	COG4589	Belongs to the CDS family
I6I51_06055	COG2915	High frequency lysogenization protein hflD homolog
I6I51_06075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I51_06080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I51_06090	COG2801	Transposase and inactivated derivatives
I6I51_06100	COG0006	proline dipeptidase activity
I6I51_06125	COG4770	biotin carboxylase activity
I6I51_06145	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I51_06150	COG0583	DNA-binding transcription factor activity
I6I51_06155	COG2217	Heavy metal translocating P-type atpase
I6I51_06165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I51_06180	COG2234	aminopeptidase activity
I6I51_06190	COG3384	dioxygenase
I6I51_06200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I51_06205	COG2878	Part of a membrane complex involved in electron transport
I6I51_06210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I51_06235	COG0768	penicillin binding
I6I51_06240	COG0742	ribosomal rna small subunit methyltransferase
I6I51_06270	COG0653	protein targeting
I6I51_06290	COG0582	viral genome integration into host DNA
I6I51_06335	COG1570	exodeoxyribonuclease VII activity
I6I51_06345	COG1877	trehalose-phosphatase activity
I6I51_06350	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I51_06355	COG2223	nitrite transmembrane transporter activity
I6I51_06400	COG2323	membrane
I6I51_06420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I51_06440	COG1335	isochorismatase
I6I51_06445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I51_06545	COG1597	lipid kinase activity
I6I51_06550	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I51_06565	COG0477	Major facilitator Superfamily
I6I51_06615	COG0604	alcohol dehydrogenase
I6I51_06615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I51_06615	COG3321	synthase
I6I51_06615	COG4221	oxidoreductase activity
I6I51_06630	COG1695	Transcriptional regulator
I6I51_06665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I51_06670	COG1773	rubredoxin
I6I51_06675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_06685	COG0583	DNA-binding transcription factor activity
I6I51_06705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I51_06710	COG4181	ATPase activity
I6I51_06735	COG4771	TonB-dependent receptor
I6I51_06755	COG0306	phosphate transporter
I6I51_06785	COG2223	nitrite transmembrane transporter activity
I6I51_06790	COG2207	Transcriptional regulator
I6I51_06795	COG0242	peptide deformylase activity
I6I51_06800	COG0477	Major facilitator Superfamily
I6I51_06840	COG0456	acetyltransferase
I6I51_06845	COG2199	diguanylate cyclase activity
I6I51_06845	COG2203	Gaf domain
I6I51_06855	COG4681	YaeQ
I6I51_06860	COG0523	cobalamin synthesis protein
I6I51_06870	COG1607	acyl-coa hydrolase
I6I51_06875	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I51_06880	COG3293	Transposase
I6I51_06890	COG1115	amino acid carrier protein
I6I51_06895	COG0786	glutamate:sodium symporter activity
I6I51_06910	COG1289	transmembrane transporter activity
I6I51_06920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I51_06990	COG2832	Protein of unknown function (DUF454)
I6I51_07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I51_07015	COG2198	Histidine kinase
I6I51_07015	COG0643	Histidine kinase
I6I51_07015	COG0784	Response regulator, receiver
I6I51_07020	COG0840	transmembrane signaling receptor activity
I6I51_07090	COG2358	TRAP transporter, solute receptor (TAXI family
I6I51_07105	COG0489	protein tyrosine kinase activity
I6I51_07130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I51_07130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I51_07180	COG4716	Myosin-crossreactive antigen
I6I51_07210	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I51_07215	COG2081	HI0933 family
I6I51_07230	COG0668	transmembrane transport
I6I51_07250	COG0765	amino acid transport
I6I51_07255	COG0765	amino acid transport
I6I51_07260	COG1126	abc transporter atp-binding protein
I6I51_07270	COG0004	ammonium transporteR
I6I51_07285	COG0642	Histidine kinase
I6I51_07290	COG0745	RESPONSE REGULATOR receiver
I6I51_07315	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I51_07330	COG0142	geranyltranstransferase activity
I6I51_07335	COG2828	Protein conserved in bacteria
I6I51_07340	COG1113	amino acid transport
I6I51_07350	COG0582	viral genome integration into host DNA
I6I51_07390	COG0305	Participates in initiation and elongation during chromosome replication
I6I51_07455	COG4372	Transposase
I6I51_07495	COG0629	single-stranded DNA binding
I6I51_07525	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_07560	COG1113	amino acid transport
I6I51_07595	COG0431	NADPH-dependent FMN reductase
I6I51_07600	COG0798	PFAM Bile acid sodium symporter
I6I51_07610	COG0640	Transcriptional regulator
I6I51_07660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I51_07675	COG0424	maF-like protein
I6I51_07680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I51_07685	COG1792	Involved in formation and maintenance of cell shape
I6I51_07690	COG1077	Cell shape determining protein MreB Mrl
I6I51_07695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I51_07705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I51_07730	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_07765	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I51_07785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I51_07810	COG0640	Transcriptional regulator
I6I51_07815	COG1136	(ABC) transporter
I6I51_07825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_07850	COG0582	viral genome integration into host DNA
I6I51_07970	COG4373	Mu-like prophage FluMu protein gp28
I6I51_07980	COG4383	Mu-like prophage protein gp29
I6I51_07985	COG2369	cell adhesion
I6I51_08080	COG3561	AntA/AntB antirepressor
I6I51_08135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I51_08140	COG2814	Major facilitator Superfamily
I6I51_08145	COG1566	PFAM secretion protein HlyD family protein
I6I51_08150	COG2050	protein possibly involved in aromatic compounds catabolism
I6I51_08165	COG1090	epimerase
I6I51_08175	COG3706	GGDEF domain
I6I51_08175	COG5001	Diguanylate cyclase
I6I51_08175	COG2203	Gaf domain
I6I51_08175	COG4251	negative regulation of phosphorylation
I6I51_08180	COG0420	3'-5' exonuclease activity
I6I51_08210	COG0735	belongs to the Fur family
I6I51_08215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I51_08220	COG2914	Belongs to the UPF0125 (RnfH) family
I6I51_08245	COG0121	glutamine amidotransferase
I6I51_08260	COG0756	dUTP diphosphatase activity
I6I51_08265	COG0210	DNA helicase
I6I51_08270	COG2885	chlorophyll binding
I6I51_08275	COG0204	Acyl-transferase
I6I51_08285	COG0850	regulation of cytokinetic process
I6I51_08295	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I51_08310	COG1674	ftsk spoiiie
I6I51_08310	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I51_08315	COG0492	ferredoxin-NADP+ reductase activity
I6I51_08320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I51_08330	COG0456	acetyltransferase
I6I51_08340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I51_08355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I51_08370	COG1981	membrane
I6I51_08380	COG1113	amino acid transport
I6I51_08385	COG0251	oxidation-reduction process
I6I51_08395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I51_08425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I51_08450	COG2132	Multicopper oxidase
I6I51_08460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I51_08495	COG1968	undecaprenyl-diphosphatase activity
I6I51_08500	COG1214	PFAM Peptidase M22, glycoprotease
I6I51_08505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I51_08510	COG0494	nUDIX hydrolase
I6I51_08545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I51_08555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I51_08580	COG0693	protein deglycase activity
I6I51_08595	COG2814	Major facilitator Superfamily
I6I51_08655	COG2199	diguanylate cyclase activity
I6I51_08660	COG2885	chlorophyll binding
I6I51_08685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I51_08690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I51_08710	COG0450	alkyl hydroperoxide reductase
I6I51_08730	COG0285	dihydrofolate synthase activity
I6I51_08800	COG4206	TonB-dependent receptor
I6I51_08805	COG2096	Adenosyltransferase
I6I51_08825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I51_08830	COG2315	Protein conserved in bacteria
I6I51_08835	COG1113	amino acid transport
I6I51_08840	COG0745	RESPONSE REGULATOR receiver
I6I51_08845	COG2205	protein histidine kinase activity
I6I51_08855	COG1960	acyl-CoA dehydrogenase activity
I6I51_08860	COG1960	acyl-CoA dehydrogenase activity
I6I51_08865	COG3223	Belongs to the PsiE family
I6I51_08895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I51_08915	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_08925	COG0438	transferase activity, transferring glycosyl groups
I6I51_08935	COG0463	Glycosyl transferase, family 2
I6I51_08955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I51_08960	COG5002	protein histidine kinase activity
I6I51_08970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I51_08980	COG1704	LemA family
I6I51_08990	COG1862	Preprotein translocase
I6I51_09015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I51_09035	COG1426	Protein conserved in bacteria
I6I51_09095	COG0440	acetolactate synthase activity
I6I51_09100	COG0028	Belongs to the TPP enzyme family
I6I51_09125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_09130	COG0577	efflux transmembrane transporter activity
I6I51_09130	COG1136	(ABC) transporter
I6I51_09135	COG1538	Outer membrane efflux protein
I6I51_09150	COG2815	serine threonine protein kinase
I6I51_09150	COG0515	serine threonine protein kinase
I6I51_09165	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I51_09170	COG1162	GTPase activity
I6I51_09195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I51_09205	COG3781	membrane
I6I51_09210	COG0613	PHP domain protein
I6I51_09220	COG2350	Protein conserved in bacteria
I6I51_09240	COG1666	GTP binding
I6I51_09255	COG1607	acyl-coa hydrolase
I6I51_09315	COG1183	phosphatidylcholine synthase activity
I6I51_09320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I51_09345	COG0039	L-malate dehydrogenase activity
I6I51_09355	COG1196	nuclear chromosome segregation
I6I51_09355	COG0741	lytic transglycosylase activity
I6I51_09355	COG0739	heme binding
I6I51_09360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I51_09365	COG1702	phosphate starvation-inducible protein PhoH
I6I51_09370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I51_09420	COG1295	ribonuclease BN
I6I51_09435	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I51_09470	COG0557	exoribonuclease II activity
I6I51_09475	COG2720	vancomycin resistance protein
I6I51_09480	COG0339	signal peptide processing
I6I51_09485	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I51_09515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I51_09520	COG1960	acyl-CoA dehydrogenase activity
I6I51_09530	COG2072	flavoprotein involved in K transport
I6I51_09535	COG0203	ribosomal protein L17
I6I51_09540	COG0202	RNA polymerase activity
I6I51_09555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I51_09580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I51_09590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I51_09595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I51_09645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I51_09660	COG0088	Forms part of the polypeptide exit tunnel
I6I51_09665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I51_09685	COG0433	COG0433 Predicted ATPase
I6I51_09695	COG1959	2 iron, 2 sulfur cluster binding
I6I51_09710	COG1301	dicarboxylic acid transport
I6I51_09715	COG1946	Acyl-CoA thioesterase
I6I51_09720	COG2937	Belongs to the GPAT DAPAT family
I6I51_09745	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_09770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I51_09775	COG1040	competence protein
I6I51_09780	COG0494	nUDIX hydrolase
I6I51_09790	COG0598	Magnesium transport protein CorA
I6I51_09800	COG2854	intermembrane phospholipid transfer
I6I51_09805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I51_09810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I51_09815	COG1127	ABC transporter
I6I51_09820	COG0513	Belongs to the DEAD box helicase family
I6I51_09840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I51_09850	COG0408	coproporphyrinogen oxidase activity
I6I51_09870	COG1960	acyl-CoA dehydrogenase activity
I6I51_09875	COG1910	domain protein
I6I51_09895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I51_09905	COG0534	Mate efflux family protein
I6I51_09915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I51_09920	COG0254	rRNA binding
I6I51_09925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I51_09940	COG2226	methyltransferase
I6I51_09950	COG1192	Involved in chromosome partitioning
I6I51_09955	COG0628	permease
I6I51_09960	COG2032	superoxide dismutase activity
I6I51_09970	COG2814	Major facilitator Superfamily
I6I51_09995	COG0277	FAD linked oxidase domain protein
I6I51_10000	COG3293	Transposase
I6I51_10005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I51_10010	COG5006	permease, DMT superfamily
I6I51_10030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I51_10035	COG5380	lipid catabolic process
I6I51_10050	COG0335	large ribosomal subunit rRNA binding
I6I51_10060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I51_10065	COG0228	four-way junction DNA binding
I6I51_10100	COG4969	Belongs to the N-Me-Phe pilin family
I6I51_10110	COG0194	GDP metabolic process
I6I51_10115	COG1758	RNA polymerase activity
I6I51_10120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I51_10140	COG3307	-O-antigen
I6I51_10145	COG3307	-O-antigen
I6I51_10165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6I51_10170	COG1704	LemA family
I6I51_10180	COG0493	'glutamate synthase
I6I51_10185	COG0067	glutamate synthase
I6I51_10185	COG0070	glutamate synthase
I6I51_10185	COG0069	glutamate synthase activity
I6I51_10235	COG2226	methyltransferase
I6I51_10245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I51_10250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I51_10270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I51_10285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I51_10305	COG0488	(ABC) transporter
I6I51_10310	COG2873	o-acetylhomoserine
I6I51_10315	COG4221	oxidoreductase activity
I6I51_10345	COG0427	acetyl-CoA hydrolase
I6I51_10380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I51_10415	COG1278	Cold shock
I6I51_10420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I51_10445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I51_10480	COG0582	viral genome integration into host DNA
I6I51_10505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I51_10575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_10595	COG0583	DNA-binding transcription factor activity
I6I51_10605	COG0629	single-stranded DNA binding
I6I51_10645	COG0629	single-stranded DNA binding
I6I51_10650	COG2814	Major facilitator Superfamily
I6I51_10660	COG0351	phosphomethylpyrimidine kinase
I6I51_10660	COG0352	thiamine-phosphate diphosphorylase activity
I6I51_10660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I51_10690	COG3706	GGDEF domain
I6I51_10700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I51_10710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I51_10715	COG3162	membrane
I6I51_10720	COG2205	protein histidine kinase activity
I6I51_10720	COG0784	Response regulator, receiver
I6I51_10735	COG0431	NADPH-dependent FMN reductase
I6I51_10750	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_10755	COG0307	riboflavin synthase, alpha
I6I51_10760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I51_10765	COG0668	transmembrane transport
I6I51_10770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I51_10775	COG1519	Transferase
I6I51_10780	COG1902	pentaerythritol trinitrate reductase activity
I6I51_10810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I51_10845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I51_10845	COG0426	domain, Protein
I6I51_10850	COG2119	membrane
I6I51_10880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I51_10890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I51_10900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I51_10910	COG0189	ligase activity
I6I51_10915	COG0386	Belongs to the glutathione peroxidase family
I6I51_10945	COG0708	Exodeoxyribonuclease III
I6I51_10950	COG1393	Belongs to the ArsC family
I6I51_10965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I51_11050	COG3150	esterase
I6I51_11060	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I51_11065	COG2918	glutathione biosynthetic process
I6I51_11080	COG2733	membrane
I6I51_11085	COG0436	Aminotransferase
I6I51_11090	COG0534	Mate efflux family protein
I6I51_11160	COG0385	Bile acid
I6I51_11165	COG1335	isochorismatase
I6I51_11170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I51_11190	COG4215	(ABC) transporter
I6I51_11195	COG4160	amino acid transport
I6I51_11215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I51_11220	COG2983	Belongs to the UPF0260 family
I6I51_11225	COG5487	UPF0391 membrane protein
I6I51_11255	COG2818	Glycosylase
I6I51_11260	COG1064	alcohol dehydrogenase
I6I51_11265	COG0436	Aminotransferase
I6I51_11280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I51_11290	COG0484	heat shock protein binding
I6I51_11310	COG1309	transcriptional regulator
I6I51_11320	COG2233	PERMEase
I6I51_11325	COG0583	DNA-binding transcription factor activity
I6I51_11355	COG0129	dihydroxy-acid dehydratase activity
I6I51_11420	COG0733	neurotransmitter:sodium symporter activity
I6I51_11460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I51_11465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I51_11470	COG2951	lytic endotransglycosylase activity
I6I51_11475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I51_11490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I51_11515	COG0861	Integral membrane protein TerC family
I6I51_11525	COG0754	glutathionylspermidine amidase activity
I6I51_11535	COG0402	S-adenosylhomocysteine deaminase activity
I6I51_11555	COG1230	cation diffusion facilitator family transporter
I6I51_11570	COG0583	DNA-binding transcription factor activity
I6I51_11585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I51_11590	COG0281	malic enzyme
I6I51_11600	COG0706	membrane insertase activity
I6I51_11605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I51_11620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I51_11625	COG0592	DNA-directed DNA polymerase activity
I6I51_11635	COG0187	DNA topoisomerase II activity
I6I51_11650	COG0488	(ABC) transporter
I6I51_11660	COG3293	Transposase
I6I51_11715	COG0657	acetylesterase activity
I6I51_11725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I51_11780	COG1047	Peptidyl-prolyl cis-trans
I6I51_11785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I51_11790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I51_11795	COG0196	riboflavin kinase activity
I6I51_11810	COG1309	transcriptional regulator
I6I51_11815	COG3293	Transposase
I6I51_11820	COG1116	anion transmembrane transporter activity
I6I51_11850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I51_11855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I51_11855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I51_11880	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_11885	COG0546	phosphoglycolate phosphatase activity
I6I51_11890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I51_11895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I51_11900	COG3307	-O-antigen
I6I51_11910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I51_11935	COG3293	Transposase
I6I51_11945	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I51_11950	COG0728	peptidoglycan biosynthetic process
I6I51_11980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I51_12005	COG0438	transferase activity, transferring glycosyl groups
I6I51_12010	COG0438	transferase activity, transferring glycosyl groups
I6I51_12015	COG0438	transferase activity, transferring glycosyl groups
I6I51_12020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I51_12025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I51_12035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I51_12050	COG1442	glycosyl transferase family 8
I6I51_12050	COG1216	Glycosyl transferase, family 2
I6I51_12075	COG1216	Glycosyl transferase, family 2
I6I51_12080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I51_12085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I51_12100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I51_12110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I51_12115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I51_12125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I51_12130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I51_12140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I51_12155	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I51_12160	COG0583	DNA-binding transcription factor activity
I6I51_12165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I51_12165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I51_12170	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I51_12175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I51_12175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_12175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_12180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I51_12240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I51_12255	COG0531	amino acid
I6I51_12260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I51_12260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I51_12265	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I51_12270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_12270	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I51_12270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I51_12280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I51_12300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I51_12305	COG0410	ABC transporter
I6I51_12330	COG0784	Response regulator, receiver
I6I51_12330	COG2205	protein histidine kinase activity
I6I51_12345	COG0830	nickel cation binding
I6I51_12360	COG0829	nickel cation binding
I6I51_12365	COG0831	urea catabolic process
I6I51_12375	COG0804	urea catabolic process
I6I51_12380	COG3293	Transposase
I6I51_12385	COG1278	Cold shock
I6I51_12420	COG0402	S-adenosylhomocysteine deaminase activity
I6I51_12430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I51_12435	COG3550	peptidyl-serine autophosphorylation
I6I51_12490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_12495	COG0842	Transport permease protein
I6I51_12495	COG1129	ABC transporter
I6I51_12500	COG0842	Transport permease protein
I6I51_12505	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I51_12535	COG3756	Protein conserved in bacteria
I6I51_12575	COG0271	Belongs to the BolA IbaG family
I6I51_12585	COG1192	Involved in chromosome partitioning
I6I51_12600	COG0586	Pfam SNARE associated Golgi protein
I6I51_12615	COG0519	Catalyzes the synthesis of GMP from XMP
I6I51_12615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I51_12670	COG0281	malic enzyme
I6I51_12685	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_12700	COG2837	iron assimilation
I6I51_12710	COG1683	Conserved Protein
I6I51_12715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I51_12720	COG1121	(ABC) transporter
I6I51_12770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I51_12805	COG0386	Belongs to the glutathione peroxidase family
I6I51_12815	COG0697	spore germination
I6I51_12825	COG0758	DNA mediated transformation
I6I51_12905	COG3293	Transposase
I6I51_12945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I51_12955	COG2814	Major facilitator Superfamily
I6I51_12975	COG1253	flavin adenine dinucleotide binding
I6I51_12980	COG3012	SEC-C Motif Domain Protein
I6I51_12985	COG2860	membrane
I6I51_12990	COG0477	Major facilitator Superfamily
I6I51_13000	COG0318	PFAM AMP-dependent synthetase and ligase
I6I51_13015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I51_13035	COG0606	chelatase, subunit chli
I6I51_13045	COG0347	Belongs to the P(II) protein family
I6I51_13050	COG0004	ammonium transporteR
I6I51_13060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I51_13060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I51_13075	COG0586	Pfam SNARE associated Golgi protein
I6I51_13095	COG0795	lipopolysaccharide-transporting ATPase activity
I6I51_13100	COG0795	lipopolysaccharide-transporting ATPase activity
I6I51_13105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I51_13110	COG0793	Belongs to the peptidase S41A family
I6I51_13125	COG2197	response regulator
I6I51_13130	COG1686	Belongs to the peptidase S11 family
I6I51_13135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I51_13145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I51_13150	COG4974	Belongs to the 'phage' integrase family
I6I51_13170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I51_13175	COG0772	Belongs to the SEDS family
I6I51_13180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I51_13185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I51_13190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I51_13200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I51_13210	COG1538	Outer membrane efflux protein
I6I51_13230	COG3275	phosphorelay sensor kinase activity
I6I51_13240	COG0181	hydroxymethylbilane synthase activity
I6I51_13260	COG0824	Thioesterase
I6I51_13290	COG0546	phosphoglycolate phosphatase activity
I6I51_13320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I51_13340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I51_13345	COG0081	regulation of translation
I6I51_13350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I51_13355	COG0222	ribosome binding
I6I51_13360	COG0085	RNA polymerase activity
I6I51_13365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I51_13390	COG2056	Na+-H+ antiporter family
I6I51_13395	COG3047	cAMP biosynthetic process
I6I51_13405	COG0326	Molecular chaperone. Has ATPase activity
I6I51_13435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I51_13510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I51_13540	COG1289	transmembrane transporter activity
I6I51_13555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I51_13565	COG0497	DNA recombination
I6I51_13575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I51_13585	COG0237	dephospho-CoA kinase activity
I6I51_13645	COG0195	Participates in both transcription termination and antitermination
I6I51_13655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I51_13660	COG1320	monovalent cation:proton antiporter activity
I6I51_13665	COG2212	antiporter activity
I6I51_13670	COG1863	multisubunit Na H antiporter MnhE subunit
I6I51_13675	COG0651	ATP synthesis coupled electron transport
I6I51_13680	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I51_13685	COG2111	Na H antiporter
I6I51_13685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I51_13690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I51_13700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I51_13715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I51_13745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I51_13750	COG1074	ATP-dependent DNA helicase activity
I6I51_13755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I51_13760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I51_13770	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I51_13805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I51_13815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I51_13835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I51_13840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I51_13845	COG4535	Mg2 and Co2 transporter CorC
I6I51_13850	COG0425	Belongs to the sulfur carrier protein TusA family
I6I51_13860	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6I51_13860	COG0644	oxidoreductase
I6I51_13870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I51_13885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I51_13890	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I51_13900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I51_13900	COG0493	'glutamate synthase
I6I51_13915	COG2226	methyltransferase
I6I51_13930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I51_13955	COG0751	glycine-tRNA ligase activity
I6I51_13980	COG1983	PspC domain protein
I6I51_14005	COG0318	PFAM AMP-dependent synthetase and ligase
I6I51_14010	COG1530	ribonuclease E activity
I6I51_14015	COG0564	pseudouridine synthase activity
I6I51_14030	COG0583	DNA-binding transcription factor activity
I6I51_14060	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_14065	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6I51_14075	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_14090	COG1960	acyl-CoA dehydrogenase activity
I6I51_14105	COG1280	lysine exporter protein (LysE YggA)
I6I51_14140	COG0583	DNA-binding transcription factor activity
I6I51_14150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I51_14165	COG0473	3-isopropylmalate dehydrogenase activity
I6I51_14225	COG1560	Kdo2-lipid A biosynthetic process
I6I51_14230	COG0488	(ABC) transporter
I6I51_14235	COG2900	Belongs to the SlyX family
I6I51_14280	COG0210	DNA helicase
I6I51_14305	COG4651	solute:proton antiporter activity
I6I51_14305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I51_14330	COG0788	formyltetrahydrofolate deformylase activity
I6I51_14435	COG2813	Specifically methylates the guanine in position
I6I51_14435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I51_14445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I51_14460	COG4774	siderophore transport
I6I51_14465	COG4771	TonB-dependent receptor
I6I51_14475	COG0740	serine-type endopeptidase activity
I6I51_14495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I51_14495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I51_14500	COG1917	Cupin 2, conserved barrel domain protein
I6I51_14500	COG2207	Transcriptional regulator
I6I51_14510	COG2318	DinB family
I6I51_14520	COG0280	phosphate acetyltransferase
I6I51_14520	COG0857	belongs to the CobB CobQ family
I6I51_14525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I51_14535	COG2267	carboxylic ester hydrolase activity
I6I51_14550	COG0793	Belongs to the peptidase S41A family
I6I51_14560	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I51_14575	COG0084	hydrolase, TatD family'
I6I51_14585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I51_14600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I51_14610	COG2814	Major facilitator Superfamily
I6I51_14635	COG0004	ammonium transporteR
I6I51_14650	COG3622	Belongs to the hyi family
I6I51_14655	COG2084	Dehydrogenase
I6I51_14660	COG1024	Enoyl-CoA hydratase
I6I51_14665	COG5002	protein histidine kinase activity
I6I51_14665	COG2205	protein histidine kinase activity
I6I51_14665	COG0784	Response regulator, receiver
I6I51_14670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I51_14685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I51_14695	COG3956	TIGRFAM MazG family protein
I6I51_14700	COG1555	photosystem II stabilization
I6I51_14705	COG0617	tRNA 3'-terminal CCA addition
I6I51_14710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I51_14720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I51_14725	COG1660	Displays ATPase and GTPase activities
I6I51_14735	COG3028	Belongs to the UPF0307 family
I6I51_14740	COG0318	PFAM AMP-dependent synthetase and ligase
I6I51_14760	COG0625	glutathione transferase activity
I6I51_14770	COG1238	metal cluster binding
I6I51_14815	COG0072	phenylalanine-tRNA ligase activity
I6I51_14840	COG0248	Ppx GppA phosphatase
I6I51_14850	COG0037	tRNA processing
I6I51_14870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I51_14870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I51_14915	COG1764	response to oxidative stress
I6I51_14920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I51_14930	COG2208	phosphoserine phosphatase activity
I6I51_14935	COG2853	Lipoprotein
I6I51_14990	COG2969	positive regulation of protein catabolic process
I6I51_14995	COG0625	glutathione transferase activity
I6I51_15005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I51_15010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I51_15020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I51_15025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I51_15030	COG4372	Transposase
I6I51_15065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I51_15075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I51_15080	COG1408	metallophosphoesterase
I6I51_15090	COG0477	Major facilitator Superfamily
I6I51_15095	COG1272	protein, Hemolysin III
I6I51_15115	COG1024	Enoyl-CoA hydratase
I6I51_15115	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I51_15120	COG0183	Belongs to the thiolase family
I6I51_15125	COG2207	Transcriptional regulator
I6I51_15130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I51_15145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I51_15165	COG0183	Belongs to the thiolase family
I6I51_15190	COG0833	amino acid
I6I51_15195	COG2813	Specifically methylates the guanine in position
I6I51_15200	COG2233	PERMEase
I6I51_15205	COG1217	gtp-binding protein TYPA
I6I51_15210	COG1970	mechanosensitive ion channel activity
I6I51_15225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I51_15235	COG3659	wide pore channel activity
I6I51_15240	COG1902	pentaerythritol trinitrate reductase activity
I6I51_15330	COG0346	lactoylglutathione lyase activity
I6I51_15335	COG0564	pseudouridine synthase activity
I6I51_15355	COG3189	MarR family transcriptional regulator
I6I51_15360	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I51_15370	COG3422	double-strand break repair
I6I51_15400	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_15410	COG2801	Transposase and inactivated derivatives
I6I51_15420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I51_15440	COG0730	response to heat
I6I51_15450	COG1196	nuclear chromosome segregation
I6I51_15455	COG3115	cell septum assembly
I6I51_15460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I51_15465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I51_15470	COG4774	siderophore transport
I6I51_15490	COG2193	ferroxidase activity
I6I51_15495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I51_15500	COG2226	methyltransferase
I6I51_15500	COG0596	Alpha beta hydrolase
I6I51_15500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I51_15515	COG4106	trans-aconitate 2-methyltransferase activity
I6I51_15560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I51_15565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I51_15575	COG0009	L-threonylcarbamoyladenylate synthase
I6I51_15580	COG3101	peptidyl-lysine hydroxylation
I6I51_15585	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I51_15600	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_15610	COG1652	LysM domain
I6I51_15615	COG1802	Transcriptional regulator
I6I51_15620	COG0439	Biotin carboxylase
I6I51_15650	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_15685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I51_15700	COG0745	RESPONSE REGULATOR receiver
I6I51_15705	COG2205	protein histidine kinase activity
I6I51_15715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I51_15735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I51_15750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I51_15760	COG0713	ATP synthesis coupled electron transport
I6I51_15765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I51_15770	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I51_15785	COG1278	Cold shock
I6I51_15790	COG1278	Cold shock
I6I51_15795	COG0583	DNA-binding transcription factor activity
I6I51_15825	COG0525	valine-tRNA ligase activity
I6I51_15835	COG1028	Short-chain dehydrogenase reductase Sdr
I6I51_15850	COG0393	Putative heavy-metal-binding
I6I51_15855	COG1538	Outer membrane efflux protein
I6I51_15865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I51_15870	COG0671	phosphoesterase, PA-phosphatase related
I6I51_15890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I51_15905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I51_15915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I51_15920	COG1648	precorrin-2 dehydrogenase activity
I6I51_15920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I51_15925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I51_15945	COG0531	amino acid
I6I51_15960	COG0321	lipoyl(octanoyl) transferase activity
I6I51_15965	COG2921	Belongs to the UPF0250 family
I6I51_16000	COG0586	Pfam SNARE associated Golgi protein
I6I51_16025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I51_16035	COG2826	transposase and inactivated derivatives, IS30 family
I6I51_16060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I51_16065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I51_16095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I51_16110	COG0358	DNA primase activity
I6I51_16120	COG0564	pseudouridine synthase activity
I6I51_16145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I51_16170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I51_16170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I51_16190	COG2072	flavoprotein involved in K transport
I6I51_16200	COG2009	succinate dehydrogenase
I6I51_16205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I51_16210	COG1053	succinate dehydrogenase
I6I51_16215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I51_16230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I51_16240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I51_16250	COG1649	PFAM Uncharacterised BCR, COG1649
I6I51_16250	COG0726	polysaccharide deacetylase
I6I51_16255	COG1215	transferase activity, transferring glycosyl groups
I6I51_16265	COG1649	PFAM Uncharacterised BCR, COG1649
I6I51_16265	COG0726	polysaccharide deacetylase
I6I51_16275	COG2268	Band 7 protein
I6I51_16290	COG2354	Protein conserved in bacteria
I6I51_16295	COG2321	neutral zinc metallopeptidase
I6I51_16315	COG3695	enzyme binding
I6I51_16340	COG0110	maltose O-acetyltransferase activity
I6I51_16350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I51_16355	COG0505	Belongs to the CarA family
I6I51_16380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I51_16385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I51_16425	COG2851	Citrate transporter
I6I51_16430	COG1253	flavin adenine dinucleotide binding
I6I51_16460	COG2239	Acts as a magnesium transporter
I6I51_16475	COG0501	Belongs to the peptidase M48B family
I6I51_16480	COG0741	lytic transglycosylase activity
I6I51_16485	COG0037	tRNA processing
I6I51_16495	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I51_16500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I51_16525	COG5006	permease, DMT superfamily
I6I51_16535	COG1309	transcriptional regulator
I6I51_16550	COG1741	Belongs to the pirin family
I6I51_16570	COG3739	integral membrane protein
I6I51_16595	COG0302	gtp cyclohydrolase
I6I51_16605	COG0300	oxidoreductase activity
I6I51_16625	COG0134	indole-3-glycerol-phosphate synthase activity
I6I51_16630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I51_16635	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I51_16640	COG0174	glutamine synthetase
I6I51_16650	COG3161	chorismate lyase activity
I6I51_16655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I51_16695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I51_16700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I51_16705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I51_16710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I51_16725	COG1115	amino acid carrier protein
I6I51_16730	COG1113	amino acid transport
I6I51_16740	COG0019	diaminopimelate decarboxylase activity
I6I51_16750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I51_16760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I51_16765	COG1522	sequence-specific DNA binding
I6I51_16770	COG1280	lysine exporter protein (LysE YggA)
I6I51_16835	COG2963	transposase activity
I6I51_16840	COG1979	alcohol dehydrogenase
I6I51_16855	COG1012	belongs to the aldehyde dehydrogenase family
I6I51_16860	COG1902	pentaerythritol trinitrate reductase activity
I6I51_16870	COG1309	transcriptional regulator
I6I51_16875	COG2130	NADP-dependent
I6I51_16885	COG1764	response to oxidative stress
I6I51_16890	COG1846	Transcriptional regulator
I6I51_16905	COG3842	ATPase activity
I6I51_16910	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I51_16925	COG3335	DDE superfamily endonuclease
I6I51_16955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I51_16975	COG0604	alcohol dehydrogenase
I6I51_16995	COG1063	alcohol dehydrogenase
I6I51_17010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I51_17095	COG4372	Transposase
I6I51_17105	COG2963	transposase activity
I6I51_17120	COG1475	DNA binding
I6I51_17125	COG1192	Involved in chromosome partitioning
I6I51_17180	COG4456	Virulence-associated protein
I6I51_17235	COG3077	Addiction module antitoxin, RelB DinJ family
I6I51_17250	COG3128	pkhd-type hydroxylase