locus-tag	class	description
I6G67_00030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G67_00035	COG1280	lysine exporter protein (LysE YggA)
I6G67_00110	COG2733	membrane
I6G67_00125	COG2918	glutathione biosynthetic process
I6G67_00130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G67_00140	COG3150	esterase
I6G67_00230	COG3706	GGDEF domain
I6G67_00235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6G67_00255	COG1393	Belongs to the ArsC family
I6G67_00260	COG0708	Exodeoxyribonuclease III
I6G67_00270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G67_00285	COG1846	Transcriptional regulator
I6G67_00290	COG0386	Belongs to the glutathione peroxidase family
I6G67_00295	COG0189	ligase activity
I6G67_00305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G67_00315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G67_00325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G67_00355	COG2119	membrane
I6G67_00360	COG0426	domain, Protein
I6G67_00360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G67_00385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G67_00410	COG1902	pentaerythritol trinitrate reductase activity
I6G67_00415	COG1519	Transferase
I6G67_00420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G67_00425	COG0668	transmembrane transport
I6G67_00430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G67_00435	COG0307	riboflavin synthase, alpha
I6G67_00440	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_00455	COG0431	NADPH-dependent FMN reductase
I6G67_00475	COG0784	Response regulator, receiver
I6G67_00475	COG2205	protein histidine kinase activity
I6G67_00480	COG3162	membrane
I6G67_00495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G67_00505	COG3706	GGDEF domain
I6G67_00530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G67_00530	COG0352	thiamine-phosphate diphosphorylase activity
I6G67_00530	COG0351	phosphomethylpyrimidine kinase
I6G67_00540	COG2814	Major facilitator Superfamily
I6G67_00545	COG0629	single-stranded DNA binding
I6G67_00605	COG0583	DNA-binding transcription factor activity
I6G67_00610	COG1301	dicarboxylic acid transport
I6G67_00625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G67_00635	COG0583	DNA-binding transcription factor activity
I6G67_00640	COG1335	isochorismatase
I6G67_00650	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6G67_00675	COG1570	exodeoxyribonuclease VII activity
I6G67_00765	COG0305	Participates in initiation and elongation during chromosome replication
I6G67_00795	COG0582	viral genome integration into host DNA
I6G67_00825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G67_00850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G67_00855	COG1278	Cold shock
I6G67_00890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G67_00925	COG0427	acetyl-CoA hydrolase
I6G67_00950	COG4221	oxidoreductase activity
I6G67_00960	COG0488	(ABC) transporter
I6G67_00980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G67_01045	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G67_01065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G67_01070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G67_01080	COG2226	methyltransferase
I6G67_01130	COG0067	glutamate synthase
I6G67_01130	COG0070	glutamate synthase
I6G67_01130	COG0069	glutamate synthase activity
I6G67_01135	COG0493	'glutamate synthase
I6G67_01145	COG1704	LemA family
I6G67_01150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G67_01210	COG4969	Belongs to the N-Me-Phe pilin family
I6G67_01245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G67_01250	COG1758	RNA polymerase activity
I6G67_01255	COG0194	GDP metabolic process
I6G67_01260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G67_01300	COG0228	four-way junction DNA binding
I6G67_01305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G67_01315	COG0335	large ribosomal subunit rRNA binding
I6G67_01330	COG5380	lipid catabolic process
I6G67_01335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G67_01355	COG5006	permease, DMT superfamily
I6G67_01360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G67_01365	COG0277	FAD linked oxidase domain protein
I6G67_01400	COG2814	Major facilitator Superfamily
I6G67_01405	COG1289	transmembrane transporter activity
I6G67_01410	COG2032	superoxide dismutase activity
I6G67_01415	COG0628	permease
I6G67_01420	COG1192	Involved in chromosome partitioning
I6G67_01430	COG2226	methyltransferase
I6G67_01445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G67_01450	COG0254	rRNA binding
I6G67_01455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G67_01465	COG0534	Mate efflux family protein
I6G67_01475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G67_01495	COG1910	domain protein
I6G67_01500	COG1960	acyl-CoA dehydrogenase activity
I6G67_01520	COG0408	coproporphyrinogen oxidase activity
I6G67_01525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G67_01535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G67_01545	COG0513	Belongs to the DEAD box helicase family
I6G67_01550	COG1127	ABC transporter
I6G67_01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G67_01560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G67_01565	COG2854	intermembrane phospholipid transfer
I6G67_01575	COG0598	Magnesium transport protein CorA
I6G67_01585	COG0494	nUDIX hydrolase
I6G67_01590	COG1040	competence protein
I6G67_01595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G67_01615	COG2801	Transposase and inactivated derivatives
I6G67_01625	COG2937	Belongs to the GPAT DAPAT family
I6G67_01630	COG1946	Acyl-CoA thioesterase
I6G67_01635	COG1301	dicarboxylic acid transport
I6G67_01650	COG1959	2 iron, 2 sulfur cluster binding
I6G67_01660	COG0433	COG0433 Predicted ATPase
I6G67_01680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G67_01685	COG0088	Forms part of the polypeptide exit tunnel
I6G67_01700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G67_01750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G67_01755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G67_01765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G67_01790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G67_01805	COG0202	RNA polymerase activity
I6G67_01810	COG0203	ribosomal protein L17
I6G67_01815	COG2072	flavoprotein involved in K transport
I6G67_01825	COG1960	acyl-CoA dehydrogenase activity
I6G67_01830	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G67_01865	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G67_01870	COG0339	signal peptide processing
I6G67_01875	COG2720	vancomycin resistance protein
I6G67_01880	COG0557	exoribonuclease II activity
I6G67_01910	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G67_01925	COG1295	ribonuclease BN
I6G67_01965	COG4773	Receptor
I6G67_01975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G67_01980	COG1702	phosphate starvation-inducible protein PhoH
I6G67_01985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G67_01990	COG0739	heme binding
I6G67_01990	COG0741	lytic transglycosylase activity
I6G67_01990	COG1196	nuclear chromosome segregation
I6G67_02000	COG0039	L-malate dehydrogenase activity
I6G67_02025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G67_02030	COG1183	phosphatidylcholine synthase activity
I6G67_02090	COG1607	acyl-coa hydrolase
I6G67_02105	COG1666	GTP binding
I6G67_02125	COG2350	Protein conserved in bacteria
I6G67_02135	COG0613	PHP domain protein
I6G67_02140	COG3781	membrane
I6G67_02150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G67_02175	COG1162	GTPase activity
I6G67_02180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G67_02195	COG1538	Outer membrane efflux protein
I6G67_02200	COG1136	(ABC) transporter
I6G67_02200	COG0577	efflux transmembrane transporter activity
I6G67_02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G67_02230	COG0028	Belongs to the TPP enzyme family
I6G67_02235	COG0440	acetolactate synthase activity
I6G67_02295	COG1426	Protein conserved in bacteria
I6G67_02315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G67_02340	COG1862	Preprotein translocase
I6G67_02350	COG1704	LemA family
I6G67_02360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G67_02370	COG5002	protein histidine kinase activity
I6G67_02375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G67_02385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G67_02395	COG0438	transferase activity, transferring glycosyl groups
I6G67_02425	COG3306	glycosyltransferase involved in LPS biosynthesis
I6G67_02445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G67_02475	COG3223	Belongs to the PsiE family
I6G67_02480	COG1960	acyl-CoA dehydrogenase activity
I6G67_02485	COG1960	acyl-CoA dehydrogenase activity
I6G67_02495	COG2205	protein histidine kinase activity
I6G67_02500	COG0745	RESPONSE REGULATOR receiver
I6G67_02505	COG1113	amino acid transport
I6G67_02510	COG2315	Protein conserved in bacteria
I6G67_02515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G67_02535	COG2096	Adenosyltransferase
I6G67_02540	COG4206	TonB-dependent receptor
I6G67_02590	COG0285	dihydrofolate synthase activity
I6G67_02610	COG0450	alkyl hydroperoxide reductase
I6G67_02630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G67_02635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G67_02665	COG2199	diguanylate cyclase activity
I6G67_02725	COG2969	positive regulation of protein catabolic process
I6G67_02730	COG0625	glutathione transferase activity
I6G67_02740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G67_02745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G67_02750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G67_02755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G67_02760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G67_02785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G67_02795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G67_02800	COG1408	metallophosphoesterase
I6G67_02815	COG0477	Major facilitator Superfamily
I6G67_02820	COG1272	protein, Hemolysin III
I6G67_02840	COG1024	Enoyl-CoA hydratase
I6G67_02840	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G67_02845	COG0183	Belongs to the thiolase family
I6G67_02850	COG2207	Transcriptional regulator
I6G67_02855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G67_02870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_02900	COG0183	Belongs to the thiolase family
I6G67_02915	COG0833	amino acid
I6G67_02920	COG2813	Specifically methylates the guanine in position
I6G67_02925	COG2233	PERMEase
I6G67_02930	COG1217	gtp-binding protein TYPA
I6G67_02935	COG1970	mechanosensitive ion channel activity
I6G67_02945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G67_02955	COG3659	wide pore channel activity
I6G67_02960	COG1902	pentaerythritol trinitrate reductase activity
I6G67_02990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G67_03035	COG0346	lactoylglutathione lyase activity
I6G67_03040	COG0564	pseudouridine synthase activity
I6G67_03060	COG3189	MarR family transcriptional regulator
I6G67_03065	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G67_03075	COG3422	double-strand break repair
I6G67_03095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G67_03100	COG0488	(ABC) transporter
I6G67_03120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G67_03140	COG0730	response to heat
I6G67_03150	COG1196	nuclear chromosome segregation
I6G67_03155	COG3115	cell septum assembly
I6G67_03165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G67_03190	COG4372	Transposase
I6G67_03240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G67_03245	COG4774	siderophore transport
I6G67_03265	COG2193	ferroxidase activity
I6G67_03270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G67_03275	COG2226	methyltransferase
I6G67_03275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_03275	COG0596	Alpha beta hydrolase
I6G67_03290	COG4106	trans-aconitate 2-methyltransferase activity
I6G67_03370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G67_03375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G67_03385	COG0009	L-threonylcarbamoyladenylate synthase
I6G67_03390	COG3101	peptidyl-lysine hydroxylation
I6G67_03395	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G67_03410	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_03420	COG1652	LysM domain
I6G67_03425	COG1802	Transcriptional regulator
I6G67_03430	COG0439	Biotin carboxylase
I6G67_03475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G67_03495	COG0745	RESPONSE REGULATOR receiver
I6G67_03500	COG2205	protein histidine kinase activity
I6G67_03510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G67_03530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6G67_03545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G67_03555	COG0713	ATP synthesis coupled electron transport
I6G67_03560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G67_03565	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G67_03580	COG1278	Cold shock
I6G67_03590	COG0583	DNA-binding transcription factor activity
I6G67_03620	COG0525	valine-tRNA ligase activity
I6G67_03630	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_03645	COG0393	Putative heavy-metal-binding
I6G67_03650	COG1538	Outer membrane efflux protein
I6G67_03660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G67_03665	COG0671	phosphoesterase, PA-phosphatase related
I6G67_03685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G67_03710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G67_03720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G67_03725	COG1648	precorrin-2 dehydrogenase activity
I6G67_03725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G67_03730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G67_03740	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_03750	COG0531	amino acid
I6G67_03765	COG0321	lipoyl(octanoyl) transferase activity
I6G67_03770	COG2921	Belongs to the UPF0250 family
I6G67_03790	COG1280	lysine exporter protein (LysE YggA)
I6G67_03805	COG0586	Pfam SNARE associated Golgi protein
I6G67_03855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G67_03860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G67_03890	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G67_03905	COG0358	DNA primase activity
I6G67_03915	COG0564	pseudouridine synthase activity
I6G67_03940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G67_03970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G67_03970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6G67_03985	COG0300	oxidoreductase activity
I6G67_03990	COG2072	flavoprotein involved in K transport
I6G67_04000	COG2009	succinate dehydrogenase
I6G67_04005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G67_04010	COG1053	succinate dehydrogenase
I6G67_04015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G67_04030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G67_04040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G67_04050	COG2268	Band 7 protein
I6G67_04055	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G67_04065	COG2354	Protein conserved in bacteria
I6G67_04070	COG2321	neutral zinc metallopeptidase
I6G67_04085	COG3695	enzyme binding
I6G67_04105	COG0110	maltose O-acetyltransferase activity
I6G67_04115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G67_04120	COG0505	Belongs to the CarA family
I6G67_04145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G67_04150	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G67_04190	COG2851	Citrate transporter
I6G67_04195	COG1253	flavin adenine dinucleotide binding
I6G67_04225	COG2239	Acts as a magnesium transporter
I6G67_04240	COG0501	Belongs to the peptidase M48B family
I6G67_04245	COG0741	lytic transglycosylase activity
I6G67_04250	COG0037	tRNA processing
I6G67_04260	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6G67_04265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G67_04295	COG1309	transcriptional regulator
I6G67_04310	COG1741	Belongs to the pirin family
I6G67_04330	COG3739	integral membrane protein
I6G67_04345	COG3706	GGDEF domain
I6G67_04355	COG0302	gtp cyclohydrolase
I6G67_04365	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_04370	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_04380	COG2909	trisaccharide binding
I6G67_04390	COG0134	indole-3-glycerol-phosphate synthase activity
I6G67_04395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G67_04400	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G67_04405	COG0174	glutamine synthetase
I6G67_04415	COG3161	chorismate lyase activity
I6G67_04420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6G67_04445	COG3550	peptidyl-serine autophosphorylation
I6G67_04475	COG0471	metal ion transport
I6G67_04515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G67_04565	COG2217	Heavy metal translocating P-type atpase
I6G67_04570	COG3174	membrane
I6G67_04575	COG2205	protein histidine kinase activity
I6G67_04590	COG2132	Multicopper oxidase
I6G67_04610	COG2433	Pfam Transposase IS66
I6G67_04675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G67_04690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G67_04695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G67_04700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G67_04720	COG1115	amino acid carrier protein
I6G67_04725	COG1113	amino acid transport
I6G67_04735	COG0019	diaminopimelate decarboxylase activity
I6G67_04745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G67_04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G67_04760	COG1522	sequence-specific DNA binding
I6G67_04805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G67_04820	COG2175	clavaminate synthase activity
I6G67_04840	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G67_04885	COG2951	lytic endotransglycosylase activity
I6G67_04900	COG0842	Transport permease protein
I6G67_04905	COG1131	(ABC) transporter
I6G67_04970	COG3723	Recombinational DNA repair protein, rece pathway
I6G67_05175	COG3646	Phage regulatory protein
I6G67_05195	COG2357	RelA SpoT domain protein
I6G67_05265	COG2365	Tyrosine phosphatase family
I6G67_05285	COG0303	'Molybdopterin
I6G67_05290	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G67_05290	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G67_05295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G67_05300	COG0243	molybdopterin cofactor binding
I6G67_05305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G67_05315	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G67_05320	COG4149	molybdate abc transporter
I6G67_05360	COG2169	Transcriptional regulator
I6G67_05365	COG0235	Class ii aldolase
I6G67_05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G67_05375	COG0697	spore germination
I6G67_05380	COG0475	glutathione-regulated potassium exporter activity
I6G67_05380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G67_05385	COG3706	GGDEF domain
I6G67_05430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G67_05455	COG3634	alkyl hydroperoxide reductase activity
I6G67_05460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G67_05465	COG0826	peptidase U32
I6G67_05495	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_05555	COG1720	tRNA m6t6A37 methyltransferase activity
I6G67_05580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G67_05595	COG0642	Histidine kinase
I6G67_05605	COG0494	nUDIX hydrolase
I6G67_05615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G67_05620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G67_05625	COG3139	Protein of unknown function (DUF1315)
I6G67_05635	COG1301	dicarboxylic acid transport
I6G67_05640	COG1960	acyl-CoA dehydrogenase activity
I6G67_05645	COG0693	protein deglycase activity
I6G67_05655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G67_05660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G67_05690	COG0415	Belongs to the DNA photolyase family
I6G67_05700	COG2252	PERMEase
I6G67_05705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G67_05715	COG3038	cytochrome b561
I6G67_05730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G67_05740	COG0527	aspartate kinase activity
I6G67_05750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G67_05765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G67_05770	COG1522	sequence-specific DNA binding
I6G67_05785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G67_05800	COG0667	Aldo Keto reductase
I6G67_05810	COG1765	OsmC-like protein
I6G67_05835	COG0540	Belongs to the ATCase OTCase family
I6G67_05855	COG2031	fatty acid transporter
I6G67_05860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_05875	COG4770	biotin carboxylase activity
I6G67_05885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G67_05890	COG1960	acyl-CoA dehydrogenase activity
I6G67_05895	COG1309	transcriptional regulator
I6G67_05900	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_05930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G67_05940	COG0659	secondary active sulfate transmembrane transporter activity
I6G67_05945	COG0625	glutathione transferase activity
I6G67_05950	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G67_05975	COG2363	Small membrane protein
I6G67_05990	COG1278	Cold shock
I6G67_05995	COG0513	Belongs to the DEAD box helicase family
I6G67_06005	COG0778	Nitroreductase
I6G67_06060	COG4783	chaperone-mediated protein folding
I6G67_06065	COG1610	YqeY-like protein
I6G67_06095	COG0515	serine threonine protein kinase
I6G67_06095	COG2815	serine threonine protein kinase
I6G67_06135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G67_06145	COG1643	Atp-dependent helicase
I6G67_06165	COG1116	anion transmembrane transporter activity
I6G67_06165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_06175	COG2223	nitrite transmembrane transporter activity
I6G67_06180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_06185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_06190	COG0243	molybdopterin cofactor binding
I6G67_06200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G67_06235	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G67_06240	COG0406	alpha-ribazole phosphatase activity
I6G67_06250	COG0517	IMP dehydrogenase activity
I6G67_06250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G67_06255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G67_06265	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G67_06270	COG1137	ATPase activity
I6G67_06290	COG4122	O-methyltransferase activity
I6G67_06300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G67_06340	COG2011	ABC-type metal ion transport system permease component
I6G67_06345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G67_06380	COG0138	bifunctional purine biosynthesis protein purh
I6G67_06385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6G67_06415	COG0445	tRNA wobble uridine modification
I6G67_06440	COG2308	Evidence 4 Homologs of previously reported genes of
I6G67_06450	COG1305	Transglutaminase-like
I6G67_06470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G67_06475	COG0305	Participates in initiation and elongation during chromosome replication
I6G67_06490	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G67_06510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G67_06515	COG1845	cytochrome c oxidase, subunit III
I6G67_06520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G67_06525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G67_06555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G67_06570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G67_06575	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G67_06580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G67_06585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_06615	COG1960	acyl-CoA dehydrogenase activity
I6G67_06620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G67_06635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G67_06660	COG0729	surface antigen
I6G67_06705	COG4773	Receptor
I6G67_06710	COG0786	glutamate:sodium symporter activity
I6G67_06720	COG1113	amino acid transport
I6G67_06745	COG0024	Methionine aminopeptidase
I6G67_06750	COG0583	DNA-binding transcription factor activity
I6G67_06755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G67_06770	COG3852	Histidine kinase
I6G67_06790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G67_06795	COG0575	Belongs to the CDS family
I6G67_06810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G67_06830	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G67_06855	COG2137	regulation of response to DNA damage stimulus
I6G67_06860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G67_06865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G67_06870	COG1011	Hydrolase
I6G67_06910	COG0702	epimerase
I6G67_06915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G67_06925	COG2267	carboxylic ester hydrolase activity
I6G67_06935	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G67_06935	COG1902	pentaerythritol trinitrate reductase activity
I6G67_06950	COG2814	Major facilitator Superfamily
I6G67_06960	COG0583	DNA-binding transcription factor activity
I6G67_06980	COG0148	phosphopyruvate hydratase activity
I6G67_06995	COG0772	Belongs to the SEDS family
I6G67_07010	COG0579	oxidoreductase
I6G67_07020	COG1012	belongs to the aldehyde dehydrogenase family
I6G67_07025	COG1309	transcriptional regulator
I6G67_07030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G67_07045	COG4890	Cyd operon protein YbgT
I6G67_07050	COG1294	oxidase, subunit
I6G67_07065	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G67_07075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G67_07095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G67_07100	COG0569	domain protein
I6G67_07110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G67_07115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6G67_07125	COG3706	GGDEF domain
I6G67_07140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G67_07145	COG0542	response to heat
I6G67_07175	COG0372	Belongs to the citrate synthase family
I6G67_07185	COG2819	hydrolase of the alpha beta superfamily
I6G67_07190	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_07210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G67_07210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G67_07215	COG1254	Belongs to the acylphosphatase family
I6G67_07220	COG1047	Peptidyl-prolyl cis-trans
I6G67_07225	COG1252	NADH dehydrogenase
I6G67_07230	COG1686	Belongs to the peptidase S11 family
I6G67_07240	COG2351	hydroxyisourate hydrolase activity
I6G67_07295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G67_07300	COG1823	symporter activity
I6G67_07310	COG0612	Peptidase, M16
I6G67_07345	COG0352	thiamine-phosphate diphosphorylase activity
I6G67_07390	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G67_07395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G67_07410	COG2353	YceI-like domain
I6G67_07415	COG0519	Catalyzes the synthesis of GMP from XMP
I6G67_07415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G67_07425	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_07435	COG4302	ethanolamine ammonia-lyase activity
I6G67_07440	COG4303	Ethanolamine ammonia lyase large subunit
I6G67_07445	COG0531	amino acid
I6G67_07465	COG1454	alcohol dehydrogenase
I6G67_07475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G67_07480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G67_07485	COG2814	Major facilitator Superfamily
I6G67_07490	COG2707	UPF0756 membrane protein
I6G67_07515	COG0802	atpase or kinase
I6G67_07520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G67_07530	COG1923	regulation of RNA biosynthetic process
I6G67_07535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G67_07545	COG3178	'Phosphotransferase
I6G67_07550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G67_07560	COG1192	Involved in chromosome partitioning
I6G67_07565	COG1475	DNA binding
I6G67_07570	COG0811	peptide transport
I6G67_07580	COG1132	(ABC) transporter
I6G67_07585	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G67_07605	COG0084	hydrolase, TatD family'
I6G67_07640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G67_07650	COG0590	tRNA wobble adenosine to inosine editing
I6G67_07670	COG0776	regulation of translation
I6G67_07685	COG2431	L-lysine efflux transmembrane transporter activity
I6G67_07700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G67_07705	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G67_07725	COG1253	flavin adenine dinucleotide binding
I6G67_07750	COG0308	aminopeptidase N
I6G67_07760	COG0589	response to stress
I6G67_07775	COG2076	Multidrug Resistance protein
I6G67_07780	COG1309	transcriptional regulator
I6G67_07785	COG3135	benzoate transporter
I6G67_07795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G67_07800	COG0583	DNA-binding transcription factor activity
I6G67_07815	COG0183	Belongs to the thiolase family
I6G67_07820	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_07840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G67_07845	COG0824	Thioesterase
I6G67_07850	COG1454	alcohol dehydrogenase
I6G67_07855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G67_07875	COG0069	glutamate synthase activity
I6G67_07880	COG2197	response regulator
I6G67_07885	COG4585	Histidine kinase
I6G67_07890	COG2850	peptidyl-arginine hydroxylation
I6G67_07905	COG0424	maF-like protein
I6G67_07915	COG0126	phosphoglycerate kinase activity
I6G67_07930	COG0697	spore germination
I6G67_07960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G67_07965	COG3781	membrane
I6G67_07995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G67_07995	COG0506	proline dehydrogenase activity
I6G67_07995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G67_08005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G67_08010	COG1027	Aspartate ammonia-lyase
I6G67_08020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G67_08050	COG0316	Belongs to the HesB IscA family
I6G67_08055	COG0822	iron-sulfur transferase activity
I6G67_08065	COG1959	2 iron, 2 sulfur cluster binding
I6G67_08080	COG0776	regulation of translation
I6G67_08085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G67_08110	COG0537	adenosine 5'-monophosphoramidase activity
I6G67_08160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G67_08190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G67_08200	COG0133	tryptophan synthase activity
I6G67_08205	COG0517	IMP dehydrogenase activity
I6G67_08230	COG0612	Peptidase, M16
I6G67_08235	COG0552	protein localization to endoplasmic reticulum
I6G67_08290	COG1960	acyl-CoA dehydrogenase activity
I6G67_08295	COG1960	acyl-CoA dehydrogenase activity
I6G67_08340	COG2199	diguanylate cyclase activity
I6G67_08350	COG2814	Major facilitator Superfamily
I6G67_08375	COG0864	Transcriptional regulator
I6G67_08445	COG0596	Alpha beta hydrolase
I6G67_08535	COG2801	Transposase and inactivated derivatives
I6G67_08605	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_08650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G67_08655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G67_08665	COG3293	Transposase
I6G67_08670	COG0456	acetyltransferase
I6G67_08675	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_08685	COG1063	alcohol dehydrogenase
I6G67_08695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G67_08840	COG2814	Major facilitator Superfamily
I6G67_08845	COG0583	DNA-binding transcription factor activity
I6G67_08850	COG4948	Mandelate Racemase Muconate Lactonizing
I6G67_08855	COG4829	muconolactone delta-isomerase
I6G67_08865	COG4638	Rieske (2fe-2S)
I6G67_08870	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G67_08875	COG0633	Ferredoxin
I6G67_08875	COG0543	2 iron, 2 sulfur cluster binding
I6G67_08880	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_08885	COG3135	benzoate transporter
I6G67_08890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G67_08895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_08900	COG0183	Belongs to the thiolase family
I6G67_08905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_08915	COG0511	ligase activity, forming carbon-carbon bonds
I6G67_08930	COG0439	Biotin carboxylase
I6G67_08945	COG0583	DNA-binding transcription factor activity
I6G67_08950	COG0183	Belongs to the thiolase family
I6G67_08960	COG3293	Transposase
I6G67_08965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G67_08970	COG0640	Transcriptional regulator
I6G67_08990	COG3122	Protein conserved in bacteria
I6G67_08995	COG0668	transmembrane transport
I6G67_09005	COG1132	(ABC) transporter
I6G67_09020	COG2814	Major facilitator Superfamily
I6G67_09030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G67_09055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6G67_09060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G67_09115	COG3293	Transposase
I6G67_09170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G67_09200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G67_09205	COG0583	DNA-binding transcription factor activity
I6G67_09210	COG1380	Effector of murein hydrolase LrgA
I6G67_09215	COG1346	cytolysis
I6G67_09230	COG2223	nitrite transmembrane transporter activity
I6G67_09245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G67_09250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G67_09255	COG2207	Transcriptional regulator
I6G67_09260	COG1944	ATP diphosphatase activity
I6G67_09265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G67_09285	COG0730	response to heat
I6G67_09290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G67_09460	COG0204	Acyl-transferase
I6G67_09500	COG1464	Belongs to the NlpA lipoprotein family
I6G67_09505	COG1464	Belongs to the NlpA lipoprotein family
I6G67_09510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G67_09515	COG2011	ABC-type metal ion transport system permease component
I6G67_09525	COG0012	GTP binding
I6G67_09550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G67_09565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G67_09595	COG0386	Belongs to the glutathione peroxidase family
I6G67_09600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G67_09605	COG0436	Aminotransferase
I6G67_09625	COG3634	alkyl hydroperoxide reductase activity
I6G67_09650	COG2070	2-Nitropropane dioxygenase
I6G67_09660	COG3038	cytochrome b561
I6G67_09680	COG1278	Cold shock
I6G67_09690	COG0604	alcohol dehydrogenase
I6G67_09695	COG1733	regulation of RNA biosynthetic process
I6G67_09715	COG3293	Transposase
I6G67_09765	COG1309	transcriptional regulator
I6G67_09790	COG0842	Transport permease protein
I6G67_09795	COG0842	Transport permease protein
I6G67_09800	COG1131	(ABC) transporter
I6G67_09840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G67_09860	COG1404	Belongs to the peptidase S8 family
I6G67_09865	COG4771	TonB-dependent receptor
I6G67_09880	COG2801	Transposase and inactivated derivatives
I6G67_09900	COG0714	Associated with various cellular activities
I6G67_09910	COG2879	small protein
I6G67_09915	COG1966	Carbon starvation protein
I6G67_09920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G67_09940	COG0254	rRNA binding
I6G67_09960	COG1067	ATP-dependent peptidase activity
I6G67_09965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G67_09970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G67_09975	COG0616	signal peptide processing
I6G67_09980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G67_09990	COG0573	inorganic phosphate transmembrane transporter activity
I6G67_09995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G67_10005	COG0076	glutamate decarboxylase activity
I6G67_10010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G67_10025	COG0671	phosphoesterase, PA-phosphatase related
I6G67_10030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G67_10040	COG1733	regulation of RNA biosynthetic process
I6G67_10045	COG0702	epimerase
I6G67_10075	COG0556	nucleotide-excision repair
I6G67_10090	COG2199	diguanylate cyclase activity
I6G67_10100	COG0436	Aminotransferase
I6G67_10135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G67_10140	COG1381	Involved in DNA repair and RecF pathway recombination
I6G67_10150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G67_10165	COG0681	Belongs to the peptidase S26 family
I6G67_10210	COG3772	lysozyme
I6G67_10325	COG4383	Mu-like prophage protein gp29
I6G67_10500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G67_10515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G67_10520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G67_10530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G67_10545	COG4208	sulfate ABC transporter
I6G67_10550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G67_10555	COG0583	DNA-binding transcription factor activity
I6G67_10575	COG0602	queuosine metabolic process
I6G67_10580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G67_10600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G67_10610	COG0583	DNA-binding transcription factor activity
I6G67_10615	COG2353	YceI-like domain
I6G67_10620	COG1056	cytidyltransferase-related domain
I6G67_10620	COG1051	belongs to the nudix hydrolase family
I6G67_10625	COG1024	Enoyl-CoA hydratase
I6G67_10630	COG0778	Nitroreductase
I6G67_10635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G67_10635	COG3323	Protein of unknown function (DUF1653)
I6G67_10645	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G67_10645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G67_10660	COG2255	four-way junction helicase activity
I6G67_10675	COG0824	Thioesterase
I6G67_10695	COG0823	Involved in the tonB-independent uptake of proteins
I6G67_10715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G67_10745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G67_10750	COG0628	permease
I6G67_10755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G67_10760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G67_10780	COG2333	competence protein COMEC
I6G67_10780	COG0658	competence protein
I6G67_10785	COG1136	(ABC) transporter
I6G67_10790	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G67_10805	COG1671	Belongs to the UPF0178 family
I6G67_10820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G67_10825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G67_10830	COG1960	acyl-CoA dehydrogenase activity
I6G67_10870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G67_10875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G67_10880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G67_10885	COG5001	Diguanylate cyclase
I6G67_10885	COG1716	ATPase activity
I6G67_10890	COG0280	phosphate acetyltransferase
I6G67_10890	COG0281	malic enzyme
I6G67_10905	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6G67_10920	COG1773	rubredoxin
I6G67_10925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G67_10970	COG1024	Enoyl-CoA hydratase
I6G67_10975	COG1960	acyl-CoA dehydrogenase activity
I6G67_10980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G67_11005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G67_11025	COG0583	DNA-binding transcription factor activity
I6G67_11035	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G67_11035	COG1902	pentaerythritol trinitrate reductase activity
I6G67_11040	COG0277	FAD linked oxidase domain protein
I6G67_11050	COG2186	Transcriptional regulator
I6G67_11065	COG5001	Diguanylate cyclase
I6G67_11065	COG4251	negative regulation of phosphorylation
I6G67_11065	COG3706	GGDEF domain
I6G67_11065	COG2203	Gaf domain
I6G67_11070	COG0418	dihydroorotase activity
I6G67_11075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G67_11090	COG0833	amino acid
I6G67_11100	COG0833	amino acid
I6G67_11125	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6G67_11140	COG4172	Belongs to the ABC transporter superfamily
I6G67_11145	COG4239	(ABC) transporter, permease
I6G67_11150	COG4174	ABC transporter (Permease)
I6G67_11155	COG4166	transmembrane transport
I6G67_11160	COG0741	lytic transglycosylase activity
I6G67_11160	COG1388	LysM domain
I6G67_11165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G67_11175	COG2816	NAD+ diphosphatase activity
I6G67_11180	COG0657	acetylesterase activity
I6G67_11200	COG0583	DNA-binding transcription factor activity
I6G67_11205	COG1388	LysM domain
I6G67_11205	COG4942	peptidase
I6G67_11215	COG0582	viral genome integration into host DNA
I6G67_11515	COG0753	catalase activity
I6G67_11530	COG0789	Transcriptional regulator
I6G67_11545	COG1686	Belongs to the peptidase S11 family
I6G67_11550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G67_11555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G67_11560	COG2267	carboxylic ester hydrolase activity
I6G67_11565	COG0671	phosphoesterase, PA-phosphatase related
I6G67_11565	COG2453	phosphatase
I6G67_11580	COG4589	Belongs to the CDS family
I6G67_11595	COG2915	High frequency lysogenization protein hflD homolog
I6G67_11615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G67_11620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G67_11625	COG2801	Transposase and inactivated derivatives
I6G67_11635	COG2801	Transposase and inactivated derivatives
I6G67_11645	COG0006	proline dipeptidase activity
I6G67_11705	COG1785	Belongs to the alkaline phosphatase family
I6G67_11710	COG1785	Belongs to the alkaline phosphatase family
I6G67_11725	COG4770	biotin carboxylase activity
I6G67_11745	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G67_11750	COG0583	DNA-binding transcription factor activity
I6G67_11760	COG2217	Heavy metal translocating P-type atpase
I6G67_11770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G67_11785	COG2234	aminopeptidase activity
I6G67_11795	COG3384	dioxygenase
I6G67_11805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G67_11810	COG2878	Part of a membrane complex involved in electron transport
I6G67_11815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G67_11840	COG0768	penicillin binding
I6G67_11845	COG0742	ribosomal rna small subunit methyltransferase
I6G67_11875	COG3119	arylsulfatase activity
I6G67_11895	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G67_11895	COG1388	LysM domain
I6G67_11920	COG1597	lipid kinase activity
I6G67_11925	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6G67_11935	COG0477	Major facilitator Superfamily
I6G67_11950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G67_11975	COG4221	oxidoreductase activity
I6G67_11975	COG3321	synthase
I6G67_11975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G67_11975	COG0604	alcohol dehydrogenase
I6G67_11990	COG1695	Transcriptional regulator
I6G67_12000	COG0210	DNA helicase
I6G67_12005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G67_12035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G67_12040	COG1773	rubredoxin
I6G67_12045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_12055	COG0583	DNA-binding transcription factor activity
I6G67_12070	COG0457	Tetratricopeptide repeat
I6G67_12070	COG0705	Rhomboid family
I6G67_12075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G67_12080	COG4181	ATPase activity
I6G67_12105	COG4771	TonB-dependent receptor
I6G67_12130	COG0306	phosphate transporter
I6G67_12145	COG2852	Protein conserved in bacteria
I6G67_12160	COG2223	nitrite transmembrane transporter activity
I6G67_12170	COG0242	peptide deformylase activity
I6G67_12175	COG0477	Major facilitator Superfamily
I6G67_12220	COG2203	Gaf domain
I6G67_12220	COG2199	diguanylate cyclase activity
I6G67_12230	COG4681	YaeQ
I6G67_12235	COG0523	cobalamin synthesis protein
I6G67_12245	COG1607	acyl-coa hydrolase
I6G67_12250	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G67_12260	COG1115	amino acid carrier protein
I6G67_12265	COG0786	glutamate:sodium symporter activity
I6G67_12280	COG2814	Major facilitator Superfamily
I6G67_12285	COG1289	transmembrane transporter activity
I6G67_12295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6G67_12365	COG2832	Protein of unknown function (DUF454)
I6G67_12380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G67_12390	COG0784	Response regulator, receiver
I6G67_12390	COG0643	Histidine kinase
I6G67_12390	COG2198	Histidine kinase
I6G67_12395	COG0840	transmembrane signaling receptor activity
I6G67_12445	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_12475	COG2358	TRAP transporter, solute receptor (TAXI family
I6G67_12490	COG0489	protein tyrosine kinase activity
I6G67_12510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G67_12510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G67_12520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G67_12545	COG4716	Myosin-crossreactive antigen
I6G67_12575	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G67_12580	COG2081	HI0933 family
I6G67_12595	COG0668	transmembrane transport
I6G67_12615	COG0765	amino acid transport
I6G67_12620	COG0765	amino acid transport
I6G67_12625	COG1126	abc transporter atp-binding protein
I6G67_12635	COG0004	ammonium transporteR
I6G67_12640	COG0546	phosphoglycolate phosphatase activity
I6G67_12650	COG0642	Histidine kinase
I6G67_12655	COG0745	RESPONSE REGULATOR receiver
I6G67_12680	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G67_12695	COG0142	geranyltranstransferase activity
I6G67_12700	COG2828	Protein conserved in bacteria
I6G67_12705	COG1113	amino acid transport
I6G67_12720	COG1113	amino acid transport
I6G67_12730	COG2433	Pfam Transposase IS66
I6G67_12755	COG0625	glutathione transferase activity
I6G67_12770	COG0431	NADPH-dependent FMN reductase
I6G67_12775	COG0798	PFAM Bile acid sodium symporter
I6G67_12785	COG0640	Transcriptional regulator
I6G67_12835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G67_12850	COG2433	Pfam Transposase IS66
I6G67_12860	COG0424	maF-like protein
I6G67_12865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G67_12870	COG1792	Involved in formation and maintenance of cell shape
I6G67_12875	COG1077	Cell shape determining protein MreB Mrl
I6G67_12880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G67_12890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G67_12905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G67_12915	COG3293	Transposase
I6G67_12940	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6G67_12960	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_12970	COG0583	DNA-binding transcription factor activity
I6G67_12980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_12990	COG4772	TonB-dependent receptor
I6G67_12995	COG4993	Dehydrogenase
I6G67_13000	COG3659	wide pore channel activity
I6G67_13005	COG3420	alginic acid biosynthetic process
I6G67_13010	COG0710	3-dehydroquinate dehydratase activity
I6G67_13015	COG3485	protocatechuate 3,4-dioxygenase
I6G67_13020	COG3485	protocatechuate 3,4-dioxygenase
I6G67_13025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G67_13030	COG2271	Major facilitator Superfamily
I6G67_13035	COG0596	Alpha beta hydrolase
I6G67_13040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G67_13045	COG0183	Belongs to the thiolase family
I6G67_13050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G67_13055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G67_13060	COG1414	Transcriptional regulator
I6G67_13070	COG1113	amino acid transport
I6G67_13080	COG3724	N-succinylarginine dihydrolase activity
I6G67_13085	COG1012	belongs to the aldehyde dehydrogenase family
I6G67_13090	COG3138	arginine N-succinyltransferase
I6G67_13100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G67_13105	COG1522	sequence-specific DNA binding
I6G67_13125	COG1012	belongs to the aldehyde dehydrogenase family
I6G67_13130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G67_13140	COG1113	amino acid transport
I6G67_13145	COG4772	TonB-dependent receptor
I6G67_13155	COG1271	oxidase subunit
I6G67_13160	COG1294	oxidase, subunit
I6G67_13170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G67_13180	COG1346	cytolysis
I6G67_13190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G67_13200	COG1522	sequence-specific DNA binding
I6G67_13215	COG2814	Major facilitator Superfamily
I6G67_13240	COG0732	type I restriction modification DNA specificity domain
I6G67_13270	COG2184	nucleotidyltransferase activity
I6G67_13300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G67_13305	COG2814	Major facilitator Superfamily
I6G67_13310	COG1566	PFAM secretion protein HlyD family protein
I6G67_13315	COG2050	protein possibly involved in aromatic compounds catabolism
I6G67_13330	COG1090	epimerase
I6G67_13340	COG5001	Diguanylate cyclase
I6G67_13340	COG2203	Gaf domain
I6G67_13340	COG3706	GGDEF domain
I6G67_13340	COG4251	negative regulation of phosphorylation
I6G67_13345	COG0420	3'-5' exonuclease activity
I6G67_13375	COG0735	belongs to the Fur family
I6G67_13380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G67_13385	COG2914	Belongs to the UPF0125 (RnfH) family
I6G67_13400	COG0121	glutamine amidotransferase
I6G67_13425	COG0756	dUTP diphosphatase activity
I6G67_13430	COG0210	DNA helicase
I6G67_13435	COG2885	chlorophyll binding
I6G67_13440	COG0204	Acyl-transferase
I6G67_13450	COG0850	regulation of cytokinetic process
I6G67_13455	COG2894	cell division
I6G67_13460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G67_13475	COG0531	amino acid
I6G67_13475	COG1674	ftsk spoiiie
I6G67_13480	COG0492	ferredoxin-NADP+ reductase activity
I6G67_13485	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G67_13495	COG0456	acetyltransferase
I6G67_13515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G67_13530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G67_13545	COG1981	membrane
I6G67_13555	COG1113	amino acid transport
I6G67_13560	COG0251	oxidation-reduction process
I6G67_13600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G67_13625	COG2132	Multicopper oxidase
I6G67_13635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G67_13670	COG1968	undecaprenyl-diphosphatase activity
I6G67_13675	COG1214	PFAM Peptidase M22, glycoprotease
I6G67_13680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G67_13685	COG0494	nUDIX hydrolase
I6G67_13735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G67_13745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G67_13810	COG2853	Lipoprotein
I6G67_13815	COG2208	phosphoserine phosphatase activity
I6G67_13825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G67_13830	COG1764	response to oxidative stress
I6G67_13860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G67_13860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G67_13875	COG0037	tRNA processing
I6G67_13885	COG0248	Ppx GppA phosphatase
I6G67_13910	COG0072	phenylalanine-tRNA ligase activity
I6G67_13960	COG1238	metal cluster binding
I6G67_13970	COG0625	glutathione transferase activity
I6G67_13990	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_13995	COG3028	Belongs to the UPF0307 family
I6G67_14005	COG1660	Displays ATPase and GTPase activities
I6G67_14010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G67_14020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G67_14025	COG0617	tRNA 3'-terminal CCA addition
I6G67_14030	COG1555	photosystem II stabilization
I6G67_14035	COG3956	TIGRFAM MazG family protein
I6G67_14045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G67_14060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G67_14065	COG5002	protein histidine kinase activity
I6G67_14065	COG2205	protein histidine kinase activity
I6G67_14065	COG0784	Response regulator, receiver
I6G67_14070	COG1024	Enoyl-CoA hydratase
I6G67_14075	COG2084	Dehydrogenase
I6G67_14080	COG3622	Belongs to the hyi family
I6G67_14095	COG0004	ammonium transporteR
I6G67_14120	COG2814	Major facilitator Superfamily
I6G67_14140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6G67_14150	COG0732	type I restriction modification DNA specificity domain
I6G67_14160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G67_14175	COG0174	glutamine synthetase
I6G67_14190	COG0745	RESPONSE REGULATOR receiver
I6G67_14195	COG2205	protein histidine kinase activity
I6G67_14205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G67_14210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G67_14290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G67_14305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G67_14315	COG0084	hydrolase, TatD family'
I6G67_14330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G67_14345	COG0793	Belongs to the peptidase S41A family
I6G67_14370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G67_14375	COG0280	phosphate acetyltransferase
I6G67_14375	COG0857	belongs to the CobB CobQ family
I6G67_14385	COG2318	DinB family
I6G67_14395	COG2207	Transcriptional regulator
I6G67_14395	COG3708	Transcriptional regulator
I6G67_14405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G67_14405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G67_14425	COG0740	serine-type endopeptidase activity
I6G67_14435	COG4771	TonB-dependent receptor
I6G67_14440	COG4774	siderophore transport
I6G67_14460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G67_14465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_14470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G67_14470	COG2813	Specifically methylates the guanine in position
I6G67_14575	COG0788	formyltetrahydrofolate deformylase activity
I6G67_14600	COG4651	solute:proton antiporter activity
I6G67_14600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G67_14625	COG0210	DNA helicase
I6G67_14630	COG1929	Belongs to the glycerate kinase type-1 family
I6G67_14675	COG2900	Belongs to the SlyX family
I6G67_14680	COG0488	(ABC) transporter
I6G67_14690	COG1560	Kdo2-lipid A biosynthetic process
I6G67_14745	COG0473	3-isopropylmalate dehydrogenase activity
I6G67_14760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G67_14770	COG0583	DNA-binding transcription factor activity
I6G67_14805	COG1280	lysine exporter protein (LysE YggA)
I6G67_14820	COG1960	acyl-CoA dehydrogenase activity
I6G67_14845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6G67_14860	COG0583	DNA-binding transcription factor activity
I6G67_14875	COG0564	pseudouridine synthase activity
I6G67_14880	COG1530	ribonuclease E activity
I6G67_14885	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_14910	COG1983	PspC domain protein
I6G67_14930	COG0751	glycine-tRNA ligase activity
I6G67_14965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G67_14980	COG2226	methyltransferase
I6G67_14995	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G67_14995	COG0493	'glutamate synthase
I6G67_15005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G67_15010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G67_15015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G67_15025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G67_15035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G67_15035	COG0644	oxidoreductase
I6G67_15065	COG0425	Belongs to the sulfur carrier protein TusA family
I6G67_15070	COG4535	Mg2 and Co2 transporter CorC
I6G67_15075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G67_15080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G67_15100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G67_15110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G67_15130	COG2841	Protein conserved in bacteria
I6G67_15135	COG0598	Magnesium transport protein CorA
I6G67_15140	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G67_15150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G67_15155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G67_15160	COG1074	ATP-dependent DNA helicase activity
I6G67_15165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G67_15185	COG2226	methyltransferase
I6G67_15195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G67_15210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G67_15220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G67_15225	COG2111	Na H antiporter
I6G67_15225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G67_15230	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G67_15235	COG0651	ATP synthesis coupled electron transport
I6G67_15240	COG1863	multisubunit Na H antiporter MnhE subunit
I6G67_15245	COG2212	antiporter activity
I6G67_15250	COG1320	monovalent cation:proton antiporter activity
I6G67_15255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G67_15265	COG0195	Participates in both transcription termination and antitermination
I6G67_15325	COG0237	dephospho-CoA kinase activity
I6G67_15335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G67_15345	COG0497	DNA recombination
I6G67_15350	COG1678	Uncharacterized ACR, COG1678
I6G67_15355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G67_15370	COG1289	transmembrane transporter activity
I6G67_15385	COG1132	(ABC) transporter
I6G67_15395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G67_15445	COG2826	transposase and inactivated derivatives, IS30 family
I6G67_15485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G67_15515	COG0326	Molecular chaperone. Has ATPase activity
I6G67_15525	COG3047	cAMP biosynthetic process
I6G67_15530	COG2056	Na+-H+ antiporter family
I6G67_15560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G67_15565	COG0085	RNA polymerase activity
I6G67_15570	COG0222	ribosome binding
I6G67_15575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G67_15580	COG0081	regulation of translation
I6G67_15585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G67_15605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G67_15635	COG0546	phosphoglycolate phosphatase activity
I6G67_15665	COG0824	Thioesterase
I6G67_15685	COG0181	hydroxymethylbilane synthase activity
I6G67_15695	COG3275	phosphorelay sensor kinase activity
I6G67_15715	COG1538	Outer membrane efflux protein
I6G67_15725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G67_15735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G67_15740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G67_15745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G67_15750	COG0772	Belongs to the SEDS family
I6G67_15755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G67_15775	COG4974	Belongs to the 'phage' integrase family
I6G67_15780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G67_15790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G67_15795	COG1686	Belongs to the peptidase S11 family
I6G67_15800	COG2197	response regulator
I6G67_15815	COG0793	Belongs to the peptidase S41A family
I6G67_15820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6G67_15825	COG0795	lipopolysaccharide-transporting ATPase activity
I6G67_15830	COG0795	lipopolysaccharide-transporting ATPase activity
I6G67_15850	COG0586	Pfam SNARE associated Golgi protein
I6G67_15865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G67_15865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G67_15875	COG0004	ammonium transporteR
I6G67_15880	COG0347	Belongs to the P(II) protein family
I6G67_15905	COG0625	glutathione transferase activity
I6G67_15960	COG0606	chelatase, subunit chli
I6G67_15980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G67_15995	COG0318	PFAM AMP-dependent synthetase and ligase
I6G67_16005	COG0477	Major facilitator Superfamily
I6G67_16010	COG2860	membrane
I6G67_16015	COG3012	SEC-C Motif Domain Protein
I6G67_16020	COG1253	flavin adenine dinucleotide binding
I6G67_16040	COG2814	Major facilitator Superfamily
I6G67_16050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G67_16125	COG0758	DNA mediated transformation
I6G67_16135	COG0697	spore germination
I6G67_16150	COG0386	Belongs to the glutathione peroxidase family
I6G67_16185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G67_16235	COG1121	(ABC) transporter
I6G67_16240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G67_16245	COG1683	Conserved Protein
I6G67_16255	COG2837	iron assimilation
I6G67_16280	COG0281	malic enzyme
I6G67_16325	COG1715	Restriction endonuclease
I6G67_16330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G67_16330	COG0519	Catalyzes the synthesis of GMP from XMP
I6G67_16335	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G67_16345	COG0586	Pfam SNARE associated Golgi protein
I6G67_16360	COG1192	Involved in chromosome partitioning
I6G67_16370	COG0271	Belongs to the BolA IbaG family
I6G67_16410	COG3756	Protein conserved in bacteria
I6G67_16430	COG4372	Transposase
I6G67_16505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G67_16510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G67_16510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G67_16510	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G67_16515	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G67_16520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G67_16520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G67_16535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G67_16540	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_16580	COG2986	histidine ammonia-lyase
I6G67_16595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G67_16605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G67_16610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G67_16625	COG0583	DNA-binding transcription factor activity
I6G67_16630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G67_16645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G67_16655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G67_16660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G67_16670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G67_16715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G67_16725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G67_16740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G67_16750	COG0662	Cupin 2, conserved barrel domain protein
I6G67_16750	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6G67_16755	COG0297	glycogen (starch) synthase activity
I6G67_16760	COG0438	transferase activity, transferring glycosyl groups
I6G67_16770	COG1215	transferase activity, transferring glycosyl groups
I6G67_16815	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G67_16825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G67_16835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G67_16840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G67_16845	COG0438	transferase activity, transferring glycosyl groups
I6G67_16850	COG0438	transferase activity, transferring glycosyl groups
I6G67_16855	COG0438	transferase activity, transferring glycosyl groups
I6G67_16880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G67_16910	COG0728	peptidoglycan biosynthetic process
I6G67_16915	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G67_16925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G67_16935	COG3307	-O-antigen
I6G67_16940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G67_16945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G67_16950	COG0546	phosphoglycolate phosphatase activity
I6G67_16955	COG1028	Short-chain dehydrogenase reductase Sdr
I6G67_16990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G67_16990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G67_16995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_17000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G67_17005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G67_17010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G67_17015	COG1116	anion transmembrane transporter activity
I6G67_17020	COG1309	transcriptional regulator
I6G67_17035	COG0196	riboflavin kinase activity
I6G67_17040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G67_17045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G67_17050	COG1047	Peptidyl-prolyl cis-trans
I6G67_17065	COG2133	pyrroloquinoline quinone binding
I6G67_17095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G67_17100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G67_17105	COG2951	lytic endotransglycosylase activity
I6G67_17110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G67_17125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G67_17145	COG0861	Integral membrane protein TerC family
I6G67_17155	COG0754	glutathionylspermidine amidase activity
I6G67_17165	COG0402	S-adenosylhomocysteine deaminase activity
I6G67_17185	COG1230	cation diffusion facilitator family transporter
I6G67_17280	COG2433	Pfam Transposase IS66
I6G67_17295	COG0582	viral genome integration into host DNA
I6G67_17305	COG0706	membrane insertase activity
I6G67_17310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G67_17325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G67_17330	COG0592	DNA-directed DNA polymerase activity
I6G67_17340	COG0187	DNA topoisomerase II activity
I6G67_17350	COG0488	(ABC) transporter
I6G67_17390	COG0443	Heat shock 70 kDa protein
I6G67_17410	COG0657	acetylesterase activity
I6G67_17420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G67_17450	COG2814	Major facilitator Superfamily
I6G67_17460	COG0733	neurotransmitter:sodium symporter activity
I6G67_17490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G67_17490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G67_17510	COG0129	dihydroxy-acid dehydratase activity
I6G67_17520	COG4774	siderophore transport
I6G67_17530	COG0583	DNA-binding transcription factor activity
I6G67_17535	COG2233	PERMEase
I6G67_17545	COG1309	transcriptional regulator
I6G67_17565	COG0484	heat shock protein binding
I6G67_17575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G67_17590	COG0436	Aminotransferase
I6G67_17595	COG1064	alcohol dehydrogenase
I6G67_17600	COG2818	Glycosylase
I6G67_17630	COG5487	UPF0391 membrane protein
I6G67_17635	COG2983	Belongs to the UPF0260 family
I6G67_17640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G67_17660	COG4160	amino acid transport
I6G67_17665	COG4215	(ABC) transporter
I6G67_17685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G67_17690	COG1335	isochorismatase
I6G67_17695	COG0385	Bile acid
I6G67_17765	COG0534	Mate efflux family protein
I6G67_17770	COG0436	Aminotransferase