locus-tag class description DT536_00010 ENOG4105EM2 membrane DT536_00020 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DT536_00090 ENOG4105WD1 Membrane DT536_00105 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DT536_00115 ENOG4105CBS Chea signal transduction histidine kinase DT536_00115 ENOG4105CBS Chea signal transduction histidine kinase DT536_00120 ENOG4105C8Q Methyl-accepting chemotaxis DT536_00125 ENOG4108ZGA chew protein DT536_00130 ENOG4105M3Z response regulator DT536_00135 ENOG4108UNF response regulator DT536_00205 ENOG4105D1F ATP-binding protein DT536_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DT536_00240 ENOG4105CY0 Metallo-Beta-Lactamase DT536_00245 ENOG4107Y60 (LipO)protein DT536_00255 ENOG4106B0W Curli production assembly transport component CsgG DT536_00295 ENOG4105K6H D-cysteine desulfhydrase DT536_00300 ENOG4105CBX hi0933 family DT536_00325 ENOG4107RP9 extracellular solute-binding protein, family 3 DT536_00330 ENOG4105EAD ABC transporter DT536_00335 ENOG4105DRP amino acid AbC transporter DT536_00340 ENOG4105CDA abc transporter atp-binding protein DT536_00355 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DT536_00365 ENOG4105DHQ Histidine kinase DT536_00370 ENOG4105XJC Two component transcriptional regulator (Winged helix family DT536_00375 ENOG4105DIJ Phosphoethanolamine transferase DT536_00410 ENOG4105D78 K07001 NTE family protein DT536_00425 ENOG4105CTB Polyprenyl synthetase DT536_00430 ENOG4105C7F AcnD-accessory protein PrpF DT536_00435 ENOG4105C85 amino acid DT536_00450 ENOG4105C85 amino acid DT536_00455 ENOG4105CGF Aromatic amino acid aminotransferase DT536_00470 ENOG4108RXX maleylacetoacetate isomerase DT536_00480 ENOG4105H3G oxidoreductase DT536_00485 ENOG4105CAU Arsenical resistance protein, ArsH DT536_00490 ENOG4105D6J arsenicaL-resistance protein DT536_00500 ENOG41082YX Transcriptional regulator, arsr family DT536_00520 ENOG4107RGH Aldehyde dehydrogenase DT536_00525 ENOG4108ZX5 transcriptional regulator DT536_00545 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein DT536_00555 ENOG4105D8T Acyltransferase DT536_00560 ENOG4105C03 ribonuclease DT536_00565 ENOG4108Z03 MAF-like protein DT536_00570 ENOG4105VQ7 Rod shape-determining protein MreD DT536_00575 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DT536_00580 ENOG4105DFF Rod shape-determining protein mreb DT536_00585 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DT536_00595 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DT536_00640 ENOG4105DTD Dehydrogenase DT536_00645 ENOG4105CY2 Citrate transporter DT536_00650 ENOG4105F04 LysR family Transcriptional regulator DT536_00660 ENOG4107QNJ CoA-transferase subunit B DT536_00670 ENOG4105CHB tonB-dependent Receptor DT536_00690 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DT536_00700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DT536_00710 ENOG41067MG lrgb family DT536_00715 ENOG4105VAW lrga family DT536_00720 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DT536_00735 ENOG4105DTR rard protein DT536_00760 ENOG4105C4W S-formylglutathione hydrolase DT536_00810 ENOG4108MGI Transcriptional regulator DT536_00830 ENOG4105DHQ Histidine kinase DT536_00845 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DT536_00875 ENOG4107VMU Membrane DT536_00905 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) DT536_00920 ENOG4107R3N Filamentation induced by cAMP protein fic DT536_00925 ENOG4107R3N Filamentation induced by cAMP protein fic DT536_00930 ENOG410890F Dynamin family DT536_00980 ENOG4108J1Q DT536_01060 ENOG4105MZU cell filamentation protein DT536_01125 ENOG4105DFP Integrase DT536_01135 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DT536_01140 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT536_01145 ENOG4105CW7 secretion protein, HlyD family DT536_01160 ENOG4105EUZ Beta-lactamase domain protein DT536_01175 ENOG4108VUY thioesterase Superfamily protein DT536_01180 ENOG4105D52 delta-aminolevulinic acid dehydratase DT536_01185 ENOG4105MWK D-amino acid dehydrogenase, small subunit DT536_01205 ENOG4107RH8 nuclease SbcCD subunit D DT536_01210 ENOG4105EYH Exonuclease DT536_01220 ENOG4105DFA alanine racemase domain protein DT536_01225 ENOG4105CZX twitching motility protein DT536_01230 ENOG4105CZX twitching motility protein DT536_01235 ENOG41090R7 Ferric uptake DT536_01245 ENOG4105VDB UPF0125 protein DT536_01260 ENOG4105E7A Glutamine amidotransferase DT536_01275 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DT536_01280 ENOG4105C4R Atp-dependent dna helicase DT536_01285 ENOG4108ZG0 Ompa motb domain protein DT536_01290 ENOG4106HNH Acyl-transferase DT536_01300 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DT536_01305 ENOG4107QMS site-determining protein DT536_01325 ENOG4105CNU cell division protein FtsK DT536_01330 ENOG4105C3M thioredoxin reductase DT536_01335 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DT536_01345 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DT536_01370 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DT536_01385 ENOG4108YXA Membrane DT536_01390 ENOG4105EXC Acyl-transferase DT536_01400 ENOG4105M4H endoribonuclease L-psp DT536_01415 ENOG4105EW9 transcriptional regulator AsnC family DT536_01425 ENOG4107XGZ Hydrolase DT536_01430 ENOG4105DWF phosphomethylpyrimidine kinase DT536_01440 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DT536_01445 ENOG4105KPY Small multidrug resistance protein DT536_01450 ENOG4105KPY Small multidrug resistance protein DT536_01465 ENOG4105E3B Multicopper oxidase DT536_01475 ENOG4105DJV ribulose-phosphate 3-epimerase DT536_01525 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DT536_01530 ENOG41072GX Peptidase M22 Glycoprotease DT536_01535 ENOG4108Z0R Transferase DT536_01540 ENOG4105P8F nudix hydrolase DT536_01590 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DT536_01600 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DT536_01670 ENOG410903C (LipO)protein DT536_01675 ENOG4108MJI response regulator DT536_01695 ENOG4108ZHJ Organic hydroperoxide resistance protein DT536_01705 ENOG4107QHF type ii secretion system protein e DT536_01725 ENOG4105C2M dna polymerase I DT536_01730 ENOG4108VIA integral membrane protein DT536_01735 ENOG4105II7 pyrroline-5-carboxylate reductase DT536_01740 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DT536_01750 ENOG4105C9X ppx gppa phosphatase DT536_01760 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DT536_01775 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DT536_01805 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DT536_01825 ENOG4105W39 Membrane DT536_01835 ENOG4105CYM Glutathione S-transferase DT536_01855 ENOG4105CEY Amp-dependent synthetase and ligase DT536_01860 ENOG4105N42 UPF0307 protein DT536_01870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DT536_01875 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DT536_01885 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DT536_01890 ENOG4105DJ0 Poly(A) Polymerase DT536_01895 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein DT536_01900 ENOG4105DXN mazG family DT536_01910 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DT536_01925 ENOG4105C6T cysteine synthase DT536_01930 ENOG4105BZU Histidine kinase DT536_01935 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase DT536_01940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DT536_01945 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DT536_01970 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DT536_01975 ENOG4105W8H transhydrogenase (subunit alpha DT536_01980 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DT536_02045 ENOG4105C4R Atp-dependent dna helicase DT536_02050 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DT536_02135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DT536_02150 ENOG4105CUZ uba thif-type nad fad binding protein DT536_02155 ENOG4107QM5 aconitate hydratase DT536_02160 ENOG4105F8V Hydrolase, tatD family DT536_02175 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DT536_02180 ENOG4105BZU Histidine kinase DT536_02185 ENOG4105CN1 protease DT536_02200 ENOG4106HB6 Alpha beta hydrolase DT536_02210 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DT536_02215 ENOG4108DNC Involved in acetate metabolism (By similarity) DT536_02230 ENOG4105DWP Membrane DT536_02235 ENOG4108MCI Transcriptional regulator, ARAC family DT536_02245 ENOG4107GFK fumarate DT536_02265 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DT536_02280 ENOG4108ESX Receptor DT536_02295 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DT536_02305 ENOG4105DWV Homoserine O-trans-acetylase DT536_02410 ENOG4105CIY formyltetrahydrofolate deformylase DT536_02420 ENOG4107RGH Aldehyde dehydrogenase DT536_02425 ENOG4105KDC 50s ribosomal protein l28 DT536_02430 ENOG4105W0E 50S ribosomal protein L33 DT536_02435 ENOG4105CKD glutathione-regulated potassium-efflux system protein DT536_02460 ENOG4105C4R Atp-dependent dna helicase DT536_02490 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DT536_02505 ENOG41069P5 Protein slyX homolog DT536_02510 ENOG4105C5H ABC transporter DT536_02515 ENOG4105D1S lipid A biosynthesis DT536_02560 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DT536_02575 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DT536_02590 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DT536_02625 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase DT536_02635 ENOG4105N14 lysine exporter protein LysE YggA DT536_02640 ENOG4105EW9 transcriptional regulator AsnC family DT536_02650 ENOG4105CSU acyl-Coa dehydrogenase DT536_02670 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) DT536_02685 ENOG4108W5M transcriptional regulator DT536_02700 ENOG4105EI2 Pseudouridine synthase DT536_02710 ENOG4105C03 ribonuclease DT536_02715 ENOG4105J5T Amp-dependent synthetase and ligase DT536_02740 ENOG41067S9 phage shock protein C, PspC DT536_02765 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DT536_02790 ENOG4105C5I Dehydrogenase DT536_02805 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DT536_02820 ENOG4105BZ8 glutamate synthase DT536_02830 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DT536_02840 ENOG4105C5X domain protein DT536_02845 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DT536_02855 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DT536_02865 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase DT536_02890 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DT536_02895 ENOG4108JU5 Magnesium and cobalt efflux protein DT536_02900 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DT536_02905 ENOG4108Z7R Chaperone CsaA DT536_02915 ENOG4108VAU general secretion pathway protein G DT536_02920 ENOG4105D7Q type ii secretion system DT536_02925 ENOG4105C25 Primosomal protein n' DT536_02935 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DT536_02955 ENOG4105Z2P Protein of unknown function (DUF465) DT536_02960 ENOG4107QUT magnesium and cobalt transport protein CorA DT536_02965 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DT536_02980 ENOG4107QYX exodeoxyribonuclease v alpha DT536_02985 ENOG4107QKA exodeoxyribonuclease V beta DT536_02990 ENOG4105DSY exodeoxyribonuclease V, gamma DT536_03000 ENOG4105CSR polyphosphate kinase 2 DT536_03020 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DT536_03035 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DT536_03045 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DT536_03050 ENOG4105D65 subunit l DT536_03055 ENOG4108ZE9 Monovalent cation H antiporter subunit C DT536_03060 ENOG4107R4Z monovalent cation h antiporter subunit d DT536_03065 ENOG4105SC1 monovalent cation H antiporter subunit E DT536_03070 ENOG4105W4C monovalent cation H antiporter subunit F DT536_03075 ENOG4105KJM monovalent cation h antiporter subunit g DT536_03080 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DT536_03090 ENOG4105CHV Transcription elongation factor NusA DT536_03120 ENOG4107EJC Preprotein translocase subunit SecG DT536_03130 ENOG4107QHF type ii secretion system protein e DT536_03145 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DT536_03155 ENOG4105C2N RNA methyltransferase TrmH family group 3 DT536_03160 ENOG4105NBK UPF0345 protein DT536_03165 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DT536_03175 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DT536_03190 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) DT536_03205 ENOG4105BZ1 (ABC) transporter DT536_03210 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DT536_03280 ENOG4107ZXU DSBA oxidoreductase DT536_03315 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DT536_03325 ENOG4105EIF outer membrane protein W DT536_03330 ENOG4105D3Y Na H antiporter DT536_03355 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DT536_03360 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DT536_03365 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DT536_03370 ENOG4108VZM 50s ribosomal protein L10 DT536_03375 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DT536_03380 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DT536_03385 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DT536_03390 ENOG4105PM1 preprotein translocase subunit SecE DT536_03430 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DT536_03440 ENOG4105GVR general secretion pathway protein D DT536_03455 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS DT536_03480 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DT536_03485 ENOG4108NEV two component transcriptional regulator, LytTR family DT536_03490 ENOG4108HRK Histidine kinase DT536_03505 ENOG4108UTW Plays a role in the regulation of phosphate uptake DT536_03510 ENOG4105DFG type I secretion outer membrane protein DT536_03520 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DT536_03530 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DT536_03535 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DT536_03540 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DT536_03545 ENOG4105CNI cell division protein FtsW DT536_03550 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DT536_03560 ENOG4105CE1 Ferrous iron transport protein b DT536_03570 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DT536_03575 ENOG4105T95 Thiol disulfide interChange protein DT536_03580 ENOG4105D6E homoserine dehydrogenase DT536_03590 ENOG41061WM D-Alanyl-D-Alanine DT536_03600 ENOG4107TUY Histidine kinase DT536_03605 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DT536_03610 ENOG4105CN1 protease DT536_03615 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DT536_03620 ENOG4108K5H permease YjgP YjgQ family protein DT536_03625 ENOG4108M8S permease YjgP YjgQ family protein DT536_03645 ENOG4105DQR SNARE associated Golgi DT536_03660 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DT536_03670 ENOG4105BZU Histidine kinase DT536_03685 ENOG4105C0P Mg chelatase subunit ChlI DT536_03700 ENOG41090KI Outer membrane porin DT536_03705 ENOG4105F0N pyrophosphate phospho-hydrolase DT536_03720 ENOG4105CEY Amp-dependent synthetase and ligase DT536_03725 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DT536_03730 ENOG41079KZ Major Facilitator Superfamily DT536_03735 ENOG4105EN6 Membrane DT536_03740 ENOG4105K5B UPF0225 protein DT536_03745 ENOG4105EE5 Membrane protein terC DT536_03750 ENOG4108URH decarboxylase DT536_03765 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT536_03775 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DT536_03795 ENOG4105CCT upf0313 protein DT536_03855 ENOG4105C79 DNA protecting protein DprA DT536_03875 ENOG4108V06 Glutathione peroxidase DT536_03910 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DT536_03920 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DT536_03935 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DT536_03960 ENOG4105FDK ABC transporter DT536_03965 ENOG4105FAV ABC, transporter DT536_03970 ENOG4105EWC Purine nucleoside phosphorylase DT536_03975 ENOG410829K Lysine exporter protein (Lyse ygga) DT536_03980 ENOG4105EZR dyp-type peroxidase family protein DT536_03990 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DT536_04000 ENOG4107R1I NAD-dependent malic enzyme DT536_04040 ENOG4105EUB pirin domain protein DT536_04055 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DT536_04060 ENOG4105WXI Bacterial OB fold (BOF) protein DT536_04070 ENOG4105DQR SNARE associated Golgi DT536_04085 ENOG4107QJE Chromosome Partitioning Protein DT536_04095 ENOG4105M85 Bola protein DT536_04135 ENOG4105ZTP Protein of unknown function (DUF1376) DT536_04180 ENOG4105MUA Resistance protein DT536_04220 ENOG4105DAX Pfam:DUF2983 DT536_04245 ENOG4108M24 von Willebrand factor, type A DT536_04255 ENOG4108M24 von Willebrand factor, type A DT536_04335 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DT536_04345 ENOG4105E5H Transposase DT536_04405 ENOG4105VYA Uncharacterized conserved protein (DUF2132) DT536_04415 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DT536_04420 ENOG4105C2D reductase DT536_04430 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DT536_04440 ENOG4107T3I fad-binding protein DT536_04460 ENOG4105C84 Histidine ammonia-lyase DT536_04475 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DT536_04505 ENOG4105DZ2 Transcriptional regulator DT536_04510 ENOG4105WPN DNA integration recombination invertion protein DT536_04520 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DT536_04525 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DT536_04535 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DT536_04540 ENOG4108ZAI phosphatidylglycerophosphatase a DT536_04550 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DT536_04555 ENOG4107QKV phosphomannomutase DT536_04560 ENOG4108MRJ DT536_04565 ENOG4105CMR udp-glucose 4-epimerase DT536_04575 ENOG4105C6Y Udp-glucose 6-dehydrogenase DT536_04580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DT536_04585 ENOG4105D3Q Sugar transferase DT536_04605 ENOG4105CG5 Glycosyl transferase (Group 1 DT536_04635 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DT536_04640 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DT536_04645 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DT536_04650 ENOG4105C1B dTDP-glucose 4-6-dehydratase DT536_04660 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DT536_04665 ENOG4107WZ3 Transferase DT536_04670 ENOG4105D3Q Sugar transferase DT536_04675 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DT536_04680 ENOG4105CGN Glycosyl transferase (Group 1 DT536_04685 ENOG4108KMV Glycosyl transferase (Group 1 DT536_04690 ENOG4105CG5 Glycosyl transferase (Group 1 DT536_04715 ENOG4107QQG Dehydrogenase DT536_04720 ENOG4105DAY polysaccharide export protein DT536_04730 ENOG4105D75 Capsular exopolysaccharide family DT536_04735 ENOG4108V1T peptidylprolyl cis-trans isomerase DT536_04740 ENOG4108V1T peptidylprolyl cis-trans isomerase DT536_04745 ENOG4105CJR Integral membrane protein (MviN DT536_04750 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DT536_04755 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DT536_04760 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DT536_04765 ENOG4105EJ2 Transcriptional regulator DT536_04770 ENOG4108YSG O-Antigen polymerase DT536_04775 ENOG4108Z33 Thiol disulfide Interchange Protein DT536_04780 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DT536_04785 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DT536_04790 ENOG4105UBK short-chain dehydrogenase reductase DT536_04810 ENOG4107QZM n-acetylglutamate synthase DT536_04815 ENOG4105GVF (ABC) transporter DT536_04820 ENOG4105GVF (ABC) transporter DT536_04825 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DT536_04830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DT536_04835 ENOG4108VM9 ABC, transporter DT536_04840 ENOG4108R86 Transcriptional regulator DT536_04855 ENOG4105DTN riboflavin biosynthesis protein ribF DT536_04860 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DT536_04865 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DT536_04870 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase DT536_04925 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DT536_04960 ENOG4108HWY Beta-lactamase DT536_04980 ENOG4108821 RND type efflux pump DT536_04985 ENOG4108821 RND type efflux pump DT536_05000 ENOG4105C5H ABC transporter DT536_05010 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DT536_05020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DT536_05025 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DT536_05030 ENOG4105VG0 50S ribosomal protein l34 DT536_05040 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DT536_05045 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DT536_05065 ENOG4105PGM cation diffusion facilitator family transporter DT536_05070 ENOG4105T95 Thiol disulfide interChange protein DT536_05080 ENOG4108UGV hypoxanthine phosphoribosyltransferase DT536_05085 ENOG4107QUY Guanine deaminase DT536_05095 ENOG4106032 Glutathionylspermidine synthase DT536_05105 ENOG4105DU1 integral membrane protein, terc DT536_05125 ENOG4105DFU Cell wall formation (By similarity) DT536_05135 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DT536_05140 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DT536_05145 ENOG4105CVE Lytic murein transglycosylase DT536_05150 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DT536_05155 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DT536_05185 ENOG4105D2S major facilitator superfamily DT536_05195 ENOG4105C8J )-transporter DT536_05240 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DT536_05260 ENOG4105C01 Dihydroxy-acid dehydratase DT536_05270 ENOG4105E0K tonB-dependent siderophore receptor DT536_05280 ENOG4105F04 LysR family Transcriptional regulator DT536_05285 ENOG4105C2W permease DT536_05295 ENOG4105XEA Tetr family transcriptional regulator DT536_05340 ENOG4105CHM Aminotransferase DT536_05345 ENOG4105DQ4 alcohol dehydrogenase DT536_05350 ENOG4108R3E Dna-3-methyladenine glycosylase i DT536_05365 ENOG4105CEN a g-specific adenine glycosylase DT536_05385 ENOG4108ZZ3 UPF0260 protein DT536_05390 ENOG4105D1H recombination factor protein RarA DT536_05400 ENOG4105EW9 transcriptional regulator AsnC family DT536_05405 ENOG4108JEH abc transporter atp-binding protein DT536_05410 ENOG4106YG3 ABC transporter DT536_05415 ENOG4105DSP amino acid AbC transporter DT536_05420 ENOG4105E89 ABC transporter DT536_05435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DT536_05440 ENOG4108RWI nicotinamidase DT536_05445 ENOG4105C09 Bile acid DT536_05485 ENOG4105KHC sulfurtransferase DT536_05495 ENOG4105BZU Histidine kinase DT536_05500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT536_05515 ENOG4107QJQ Mate efflux family protein DT536_05520 ENOG4105CHM Aminotransferase DT536_05525 ENOG4106BRA Membrane DT536_05540 ENOG4105D9M gamma-glutamylcysteine synthetase DT536_05545 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) DT536_05555 ENOG4105IPS esterase DT536_05560 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DT536_05570 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein DT536_05575 ENOG4105C32 Amino acid ABC transporter (Permease) DT536_05585 ENOG4105C0Z ABC transporter DT536_05590 ENOG4108IV0 ABC, transporter DT536_05640 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DT536_05655 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DT536_05670 ENOG4105KUZ arsenate reductase DT536_05675 ENOG4105CGK Exodeoxyribonuclease III DT536_05685 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DT536_05700 ENOG4105K56 Transcriptional regulator DT536_05705 ENOG4108V06 Glutathione peroxidase DT536_05710 ENOG4105D7Z glutathione synthase DT536_05720 ENOG4105DFU Cell wall formation (By similarity) DT536_05730 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) DT536_05735 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DT536_05740 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DT536_05760 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DT536_05765 ENOG4107QSN dihydrolipoamide acetyltransferase DT536_05785 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DT536_05810 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DT536_05835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DT536_05840 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase DT536_05855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DT536_05860 ENOG4108R6K riboflavin synthase, subunit alpha DT536_05865 ENOG4105CHR reductase DT536_05875 ENOG4105FBW Monooxygenase DT536_05880 ENOG4108UZX fmn reductase DT536_05895 ENOG4105BZU Histidine kinase DT536_05900 ENOG41062QD Membrane DT536_05915 ENOG4105C94 Transporter DT536_05925 ENOG4105BZU Histidine kinase DT536_05935 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DT536_05955 ENOG4105DWF phosphomethylpyrimidine kinase DT536_05965 ENOG4107RDB Major Facilitator DT536_05970 ENOG4108UUM single-stranded DNA-binding protein DT536_06020 ENOG4105E3B Multicopper oxidase DT536_06035 ENOG4105GR3 Histidine kinase DT536_06040 ENOG4107PU6 Membrane DT536_06045 ENOG4105C59 p-type ATPase DT536_06140 ENOG4108UUM single-stranded DNA-binding protein DT536_06145 ENOG4108IJ0 Aspartate ammonia-lyase DT536_06150 ENOG4107YNJ LysR family Transcriptional regulator DT536_06155 ENOG4105CK2 sodium dicarboxylate symporter DT536_06170 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DT536_06175 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) DT536_06180 ENOG4105D3R alkyl hydroperoxide reductase DT536_06185 ENOG4105JQN Transcriptional regulator DT536_06195 ENOG4105EUB pirin domain protein DT536_06245 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DT536_06275 ENOG4105CUV Homoserine Kinase DT536_06280 ENOG4105VEQ Cold shock protein DT536_06300 ENOG4105CUB amino acid DT536_06305 ENOG4105CJP fad dependent oxidoreductase DT536_06340 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DT536_06375 ENOG4105CYC Transferase DT536_06380 ENOG4105E0F Histidine kinase DT536_06385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DT536_06405 ENOG4105PDP Short chain dehydrogenase DT536_06415 ENOG4105C5H ABC transporter DT536_06435 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DT536_06445 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DT536_06450 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DT536_06465 ENOG4105CJN penicillin-binding protein DT536_06470 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DT536_06475 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) DT536_06485 ENOG4105DHI Methyltransferase DT536_06490 ENOG4108JQC penicillin-binding protein 1A DT536_06515 ENOG4105E4G Type IV pilus DT536_06535 ENOG4105CBC glutamate synthase DT536_06540 ENOG4105BZ8 glutamate synthase DT536_06550 ENOG4108V0P LemA family DT536_06555 ENOG4105HA9 of methanol dehydrogenase type DT536_06575 ENOG4108UQY Iron-storage protein DT536_06585 ENOG4105KME endoribonuclease L-psp DT536_06590 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DT536_06595 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) DT536_06600 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DT536_06645 ENOG4105K5M 30s ribosomal protein S16 DT536_06650 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DT536_06660 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DT536_06665 ENOG4107IFA Lipase (EC 3.1.1.3) DT536_06670 ENOG4107IFA Lipase (EC 3.1.1.3) DT536_06675 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) DT536_06680 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DT536_06700 ENOG4107AQZ Membrane DT536_06705 ENOG4108JQ1 Dehydrogenase DT536_06710 ENOG4105CQB FAD linked oxidase domain protein DT536_06725 ENOG4107QF7 multi-drug DT536_06730 ENOG4105VCH membrane DT536_06735 ENOG4105EM2 membrane DT536_06740 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DT536_06745 ENOG4105IPI Membrane DT536_06750 ENOG4107SKI cobyrinic Acid a,c-diamide synthase DT536_06760 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DT536_06775 ENOG4105WMR Protein CrcB homolog DT536_06780 ENOG4105NRA 50s ribosomal protein l31 type b DT536_06795 ENOG4107QI1 Mate efflux family protein DT536_06805 ENOG4105CSA Coproporphyrinogen iii oxidase DT536_06815 ENOG4105CSU acyl-Coa dehydrogenase DT536_06835 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) DT536_06840 ENOG4105D4P Coproporphyrinogen iii oxidase DT536_06855 ENOG4105ECY inositol monophosphatase DT536_06860 ENOG4105C1J atp-dependent rna helicase DT536_06865 ENOG4105DHJ ABC, transporter DT536_06870 ENOG4105CY3 ABC transporter, permease DT536_06875 ENOG4107PE3 Mammalian cell entry related domain protein DT536_06880 ENOG4105E3I toluene tolerance DT536_06890 ENOG4107QUT magnesium and cobalt transport protein CorA DT536_06895 ENOG4108URH decarboxylase DT536_06900 ENOG4105M6F mutator MutT protein DT536_06905 ENOG4105MJ2 Competence protein DT536_06910 ENOG4105CB5 ATP-dependent DNA helicase recG DT536_06935 ENOG4105E55 glycerol-3-phosphate acyltransferase DT536_06940 ENOG4105C29 acyl-CoA thioesterase DT536_06965 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DT536_06970 ENOG4105D7A ATP-binding protein DT536_06980 ENOG41089BK Glutamine amido-transferase DT536_06990 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DT536_06995 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DT536_07010 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DT536_07015 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DT536_07060 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DT536_07065 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DT536_07075 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DT536_07090 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DT536_07095 ENOG41067V7 50S ribosomal protein L36 DT536_07100 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DT536_07105 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DT536_07115 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DT536_07120 ENOG4108ZT0 50S ribosomal protein l17 DT536_07125 ENOG4105CT3 Monooxygenase DT536_07170 ENOG4105VKU nucleicacid-binding protein DT536_07175 ENOG4105DGW oligopeptidase A DT536_07180 ENOG41073R8 VanW family DT536_07185 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DT536_07215 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DT536_07230 ENOG4107S2Z UPF0761 membrane protein DT536_07235 ENOG4105CS1 NAD(P)H quinone oxidoreductase DT536_07245 ENOG4105BZU Histidine kinase DT536_07275 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DT536_07280 ENOG4105C9A Phoh family DT536_07285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DT536_07290 ENOG4105E4C Lytic transglycosylase catalytic DT536_07300 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DT536_07325 ENOG4105D6S protein involved in catabolism of external DNA DT536_07330 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DT536_07375 ENOG4107QPB Beta-lactamase domain protein DT536_07390 ENOG4105NAU thioesterase Superfamily protein DT536_07405 ENOG4108VPT UPF0234 protein DT536_07425 ENOG4105K9H YciI-like protein DT536_07435 ENOG4105DB7 PHP domain protein DT536_07440 ENOG4105FFC UPF0187 protein DT536_07450 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DT536_07465 ENOG4105VW4 glutaredoxin 3 DT536_07475 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DT536_07480 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DT536_07490 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DT536_07505 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DT536_07510 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DT536_07515 ENOG4105DJY efflux transporter, rnd family, mfp subunit DT536_07540 ENOG4105C7K acetolactate synthase DT536_07545 ENOG4108ZP8 Acetolactate synthase small subunit DT536_07585 ENOG4105WVQ Fe-S assembly protein IscX DT536_07605 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) DT536_07625 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DT536_07640 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DT536_07645 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DT536_07650 ENOG4105VIE preprotein translocase, subunit YajC DT536_07660 ENOG4108V0P LemA family DT536_07670 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DT536_07680 ENOG4105BZU Histidine kinase DT536_07685 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DT536_07690 ENOG4105CM2 brancheD-chain amino acid aminotransferase DT536_07695 ENOG4105C6Y Udp-glucose 6-dehydrogenase DT536_07735 ENOG410650X lipopolysaccharide core region biosynthetic process DT536_07750 ENOG4105C9M aspartyl-trna synthetase DT536_07760 ENOG4105UGU tonB-dependent Receptor DT536_07780 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DT536_07785 ENOG4105CSU acyl-Coa dehydrogenase DT536_07790 ENOG4105CSU acyl-Coa dehydrogenase DT536_07800 ENOG4105EB3 Histidine kinase DT536_07805 ENOG4105E3W Two component transcriptional regulator (Winged helix family DT536_07810 ENOG4105C85 amino acid DT536_07815 ENOG4105MSB protein, conserved in bacteria DT536_07820 ENOG4105CNG UPF0061 protein DT536_07840 ENOG4108WBT adenosyltransferase DT536_07845 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DT536_07855 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DT536_07905 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DT536_07925 ENOG4105D3R alkyl hydroperoxide reductase DT536_07945 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DT536_07950 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DT536_07980 ENOG4108KHX Diguanylate cyclase DT536_07985 ENOG4108WS1 DT536_08040 ENOG4105KB2 stringent starvation protein b DT536_08045 ENOG4107MKT Stringent starvation protein a DT536_08055 ENOG4108UJD 30S ribosomal protein S9 DT536_08060 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DT536_08065 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DT536_08070 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DT536_08075 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DT536_08100 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DT536_08110 ENOG4107RZC phospholipase d DT536_08125 ENOG4105CSH Transporter DT536_08130 ENOG4108UT2 hemolysin iii DT536_08150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DT536_08155 ENOG4105CHU acetyl-coa acetyltransferase DT536_08160 ENOG4108R6W Transcriptional regulator, ARAC family DT536_08165 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DT536_08170 ENOG4105TW1 Carbohydrate-selective porin OprB DT536_08175 ENOG4105DZG Dehydrogenase DT536_08180 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DT536_08190 ENOG410814C multidrug resistance protein DT536_08200 ENOG4105CHU acetyl-coa acetyltransferase DT536_08210 ENOG4108WHA ompa motb domain protein DT536_08215 ENOG4108IQI permease DT536_08220 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) DT536_08225 ENOG4105C2W permease DT536_08235 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DT536_08245 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DT536_08255 ENOG4105TW1 Carbohydrate-selective porin OprB DT536_08260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DT536_08295 ENOG4108I0Z Aconitate hydratase DT536_08345 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DT536_08350 ENOG4105D3G Pseudouridine synthase DT536_08370 ENOG4105K78 MarR family Transcriptional regulator DT536_08375 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DT536_08390 ENOG4105KWI UPF0339 protein DT536_08415 ENOG4105C5H ABC transporter DT536_08430 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DT536_08450 ENOG4105HF0 Membrane DT536_08460 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DT536_08465 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) DT536_08470 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DT536_08475 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase DT536_08495 ENOG4108UWD Iron-storage protein DT536_08500 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DT536_08510 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DT536_08520 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DT536_08525 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DT536_08530 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DT536_08535 ENOG4105SG9 biopolymer transport protein, ExbD DT536_08555 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DT536_08585 ENOG4108JQ6 ABC transporter DT536_08590 ENOG4105FE9 pseudouridine synthase DT536_08595 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DT536_08600 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DT536_08610 ENOG4107RTD sua5 ycio yrdc ywlc family protein DT536_08615 ENOG4108BPE -transporting atpase DT536_08620 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein DT536_08625 ENOG4105VGS 50s ribosomal protein l32 DT536_08630 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DT536_08635 ENOG4105CHR reductase DT536_08645 ENOG4109066 lysm domain bon superfamily protein DT536_08650 ENOG4105DRR Transcriptional regulator, GntR family DT536_08655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DT536_08670 ENOG4105CS6 Rhs element vgr protein DT536_08675 ENOG4105CNA YD repeat protein DT536_08690 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DT536_08695 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DT536_08700 ENOG4107EXC regulatoR DT536_08705 ENOG4105JJR Histidine kinase DT536_08715 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DT536_08730 ENOG4105GKE subunit e DT536_08735 ENOG4107QIZ NADH dehydrogenase DT536_08740 ENOG4108IEH NADH dehydrogenase subunit g DT536_08750 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DT536_08755 ENOG4107UFS subunit j DT536_08760 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DT536_08765 ENOG4105D65 subunit l DT536_08770 ENOG4105C8S subunit m DT536_08780 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DT536_08785 ENOG4105VEQ Cold shock protein DT536_08790 ENOG4105VEQ Cold shock protein DT536_08795 ENOG4105DUM transcriptional regulator, lysR family DT536_08800 ENOG4105DP0 ferredoxin-NADP reductase DT536_08840 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DT536_08850 ENOG4105CHR reductase DT536_08865 ENOG4105K8R UPF0145 protein DT536_08870 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DT536_08875 ENOG4105BZS acriflavin resistance protein DT536_08880 ENOG4105C1P efflux transporter, rnd family, mfp subunit DT536_08885 ENOG410841Q phosphoesterase PA-phosphatase related protein DT536_08905 ENOG4105K46 50S ribosomal protein l27 DT536_08920 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) DT536_08930 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DT536_08935 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DT536_08940 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DT536_08960 ENOG4105CUB amino acid DT536_08975 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DT536_08980 ENOG4108Z43 UPF0250 protein DT536_08985 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT536_09000 ENOG4105CCF Lysine exporter protein (Lyse ygga) DT536_09015 ENOG4107T5V SNARE associated Golgi DT536_09055 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DT536_09085 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DT536_09115 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) DT536_09130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DT536_09135 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DT536_09140 ENOG4105C34 Pseudouridine synthase DT536_09145 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DT536_09165 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DT536_09190 ENOG4105C4K Nad synthetase DT536_09210 ENOG4105F95 Monooxygenase DT536_09220 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit DT536_09225 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein DT536_09235 ENOG4105E33 succinate dehydrogenase DT536_09240 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DT536_09245 ENOG4105C7S Dehydrogenase DT536_09250 ENOG4107QN2 dihydrolipoyl dehydrogenase DT536_09260 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DT536_09270 ENOG4107S78 Band 7 protein DT536_09275 ENOG4105PV3 Inner membrane protein yqiJ DT536_09285 ENOG4105CKW Inner membrane protein yedI DT536_09290 ENOG4105CGZ zinc metallopeptidase DT536_09300 ENOG4105EEQ Na H antiporter DT536_09305 ENOG41080UX Methyltransferase DT536_09330 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DT536_09335 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DT536_09350 ENOG4105HBR Rna-binding protein DT536_09360 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DT536_09365 ENOG4105EEI dihydropteroate synthase DT536_09405 ENOG4105D4T Citrate transporter DT536_09410 ENOG4105C37 (CBS) domain DT536_09420 ENOG4107RET Isocitrate lyase DT536_09425 ENOG41080IJ Diacylglycerol kinase DT536_09435 ENOG4105BZS acriflavin resistance protein DT536_09440 ENOG4105CJW magnesium transporter DT536_09455 ENOG4105D0M Protease HtpX homolog DT536_09460 ENOG4105E4C Lytic transglycosylase catalytic DT536_09465 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) DT536_09480 ENOG4108RRZ Transcription elongation factor GreB DT536_09520 ENOG4108WUH Transcriptional regulator, TetR family DT536_09535 ENOG4105C2I pirin domain protein DT536_09555 ENOG4105NX3 Membrane DT536_09570 ENOG4105BZU Histidine kinase DT536_09580 ENOG4105EUJ GTP cyclohydrolase i DT536_09590 ENOG4105E0T Short-chain dehydrogenase reductase Sdr DT536_09615 ENOG4105DK0 Indole-3-glycerol phosphate synthase DT536_09620 ENOG4107QYG anthranilate phosphoribosyltransferase DT536_09625 ENOG4105DDQ anthranilate synthase DT536_09630 ENOG4105C5F glutamine synthetase DT536_09645 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DT536_09685 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DT536_09690 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DT536_09695 ENOG4107QNR UPF0135 protein DT536_09700 ENOG4105C0H protease DT536_09710 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DT536_09715 ENOG4105BZG amino acid carrier protein DT536_09720 ENOG4105C85 amino acid DT536_09730 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DT536_09740 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DT536_09750 ENOG4108428 Inherit from COG: -acetyltransferase DT536_09755 ENOG4108YXU transcriptional regulator AsnC family DT536_09760 ENOG4105N14 lysine exporter protein LysE YggA DT536_09765 ENOG4105BZJ Electron transfer flavoprotein DT536_09770 ENOG4105C10 Electron transfer flavoprotein DT536_09780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DT536_09795 ENOG4108KYE ABC-2 type transporter DT536_09800 ENOG4107V40 secretion protein, HlyD family DT536_09815 ENOG4105E2B Taurine dioxygenase DT536_09830 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DT536_09835 ENOG4105CE9 30S ribosomal protein S2 DT536_09870 ENOG4105CVE Lytic murein transglycosylase DT536_09885 ENOG4105E3A (ABC) transporter DT536_09890 ENOG4105DA5 (ABC) transporter DT536_09905 ENOG4105CVM Molybdenum cofactor synthesis domain protein DT536_09910 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DT536_09940 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DT536_09945 ENOG4105E0C molybdate abc transporter DT536_09950 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DT536_10015 ENOG4105NXH GreA GreB family elongation factor DT536_10040 ENOG4108JU3 Alkyl hydroperoxide reductase DT536_10050 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DT536_10055 ENOG4105CFP Peptidase U32 DT536_10110 ENOG4105DP0 ferredoxin-NADP reductase DT536_10115 ENOG4108R96 Methyltransferase, YaeB family DT536_10135 ENOG4107QHF type ii secretion system protein e DT536_10145 ENOG4105XJC Two component transcriptional regulator (Winged helix family DT536_10150 ENOG4105DHQ Histidine kinase DT536_10160 ENOG4105M6F mutator MutT protein DT536_10170 ENOG4105BZ4 penicillin-binding protein DT536_10175 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DT536_10180 ENOG4105VUT cytoplasmic protein DT536_10190 ENOG4108I0Q anthranilate phosphoribosyltransferase DT536_10195 ENOG4105CK2 sodium dicarboxylate symporter DT536_10200 ENOG4105C1G acyl-Coa dehydrogenase DT536_10205 ENOG4107R7Y intracellular protease Pfpi family DT536_10210 ENOG4105CQC Prephenate dehydratase DT536_10215 ENOG4105CIH Imidazole acetol-phosphate transaminase DT536_10220 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DT536_10250 ENOG4105CVP deoxyribo-dipyrimidine photolyase DT536_10260 ENOG4105C7N Xanthine uracil vitamin C permease DT536_10265 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DT536_10290 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DT536_10300 ENOG4105CFH Aspartokinase DT536_10310 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DT536_10325 ENOG4108UMN azlc family DT536_10330 ENOG4108XM1 transcriptional regulator AsnC family DT536_10345 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DT536_10360 ENOG4105CPC Aldo Keto reductase DT536_10365 ENOG4107RYR Transcriptional regulator, Crp Fnr family DT536_10370 ENOG4108UKZ OsmC family DT536_10375 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DT536_10395 ENOG4105CXT aspartate transcarbamylase DT536_10400 ENOG4105CD3 dihydroorotase DT536_10415 ENOG4105CRW Short chain fatty acid transporter DT536_10420 ENOG4107QNJ CoA-transferase subunit B DT536_10430 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DT536_10445 ENOG4107QX3 carboxylase DT536_10450 ENOG4105C1G acyl-Coa dehydrogenase DT536_10455 ENOG4108SGK Tetr family transcriptional regulator DT536_10460 ENOG4105CEY Amp-dependent synthetase and ligase DT536_10490 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DT536_10500 ENOG4105CHH sulfate transporter DT536_10505 ENOG4108K3A Glutathione S-transferase DT536_10510 ENOG4105NF4 modulator of drug activity DT536_10535 ENOG4105M08 Membrane DT536_10540 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT536_10555 ENOG4105C1J atp-dependent rna helicase DT536_10565 ENOG41069NU Nitroreductase DT536_10590 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DT536_10600 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DT536_10620 ENOG4105ERG peptidase m48, ste24p DT536_10625 ENOG4105KTH gatB Yqey DT536_10630 ENOG4105VCC 30S ribosomal protein S21 DT536_10655 ENOG4105D9P serine threonine protein kinase DT536_10695 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DT536_10700 ENOG4105D3R alkyl hydroperoxide reductase DT536_10705 ENOG4105CQ7 ATP-dependent helicase DT536_10735 ENOG4107RNU major facilitator superfamily MFS_1 DT536_10740 ENOG4107QZF nitrite reductase NADPH large subunit DT536_10745 ENOG4108IFG nitrite reductase, (NAD(P)H) DT536_10760 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DT536_10790 ENOG4108YZT Adenosylcobinamide kinase DT536_10795 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DT536_10810 ENOG4105C2X Arabinose 5-phosphate isomerase DT536_10815 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase DT536_10825 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA DT536_10830 ENOG4108IUZ ABC transporter DT536_10865 ENOG4108Z4U Ferredoxin DT536_10895 ENOG4105C0B DNA polymerase III (alpha subunit) DT536_10905 ENOG4108UMI ABC transporter, permease DT536_10910 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DT536_10915 ENOG4105D01 (LipO)protein DT536_10945 ENOG4105C12 Phosphoribosylglycinamide synthetase DT536_10950 ENOG4105DC1 bifunctional purine biosynthesis protein purh DT536_10955 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DT536_10985 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DT536_11025 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DT536_11030 ENOG4105CDU Replicative dna helicase DT536_11065 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DT536_11070 ENOG4105CCU oxidase (Subunit III) DT536_11075 ENOG4105BZ9 Cytochrome C oxidase, subunit I DT536_11080 ENOG4105E2S oxidase) subunit II DT536_11110 ENOG4105DEN Luciferase family DT536_11125 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DT536_11130 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DT536_11135 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DT536_11140 ENOG4105GVF (ABC) transporter DT536_11160 ENOG4108ZX5 transcriptional regulator DT536_11175 ENOG4105C1G acyl-Coa dehydrogenase DT536_11185 ENOG4105D06 uba thif-type nad fad binding protein DT536_11195 ENOG4105KRF dihydroneopterin aldolase DT536_11215 ENOG4107S74 Lysophospholipid transporter LplT DT536_11220 ENOG4105CFU surface antigen DT536_11250 ENOG4107QIJ Aconitate hydratase 2 DT536_11265 ENOG4105CNM Receptor DT536_11270 ENOG4105D6U Sodium Glutamate Symporter DT536_11275 ENOG4105EW9 transcriptional regulator AsnC family DT536_11280 ENOG4105C85 amino acid DT536_11300 ENOG4105CWM branched-chain amino acid transport system II carrier protein DT536_11305 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DT536_11310 ENOG4105HEI LysR family (Transcriptional regulator DT536_11315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DT536_11325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DT536_11330 ENOG4105CUX Signal transduction histidine kinase DT536_11350 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DT536_11355 ENOG4105KNE Phosphatidate cytidylyltransferase DT536_11365 ENOG4105DZP Membrane-associated zinc metalloprotease DT536_11370 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DT536_11390 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DT536_11415 ENOG4105Y3E Modulates RecA activity (By similarity) DT536_11420 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DT536_11425 ENOG4105VEJ Heat shock protein DT536_11430 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 DT536_11445 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase DT536_11470 ENOG4105K4T epimerase DT536_11475 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) DT536_11485 ENOG4108MXF Alpha Beta Hydrolase DT536_11495 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DT536_11510 ENOG4105F27 Major Facilitator DT536_11515 ENOG4105CV8 reductase DT536_11520 ENOG4105HEI LysR family (Transcriptional regulator DT536_11540 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DT536_11545 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DT536_11555 ENOG4105CNI cell division protein FtsW DT536_11570 ENOG4105DWT malate dehydrogenase (quinone) DT536_11585 ENOG4105C26 Dehydrogenase DT536_11590 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DT536_11595 ENOG4105C94 Transporter DT536_11615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DT536_11620 ENOG4105C4M (Ubiquinol oxidase) subunit I DT536_11635 ENOG4105PV3 Inner membrane protein yqiJ DT536_11660 ENOG4105HDD phospholipase DT536_11665 ENOG4105CZN Potassium uptake protein DT536_11680 ENOG4105C7B Threonine dehydratase DT536_11685 ENOG4105E66 phosphoriboisomerase A DT536_11710 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DT536_11715 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DT536_11740 ENOG4105CR4 methylisocitrate lyase DT536_11745 ENOG4105BZN citrate synthase DT536_11755 ENOG4105NIV Esterase DT536_11760 ENOG4105CEY Amp-dependent synthetase and ligase DT536_11780 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DT536_11785 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DT536_11790 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) DT536_11795 ENOG4108YZY peptidylprolyl cis-trans isomerase DT536_11800 ENOG4105CEP NADH dehydrogenase DT536_11805 ENOG4105DZ1 carboxypeptidase DT536_11815 ENOG4105VT2 5-hydroxyisourate hydrolase DT536_11820 ENOG4105E9K Isocitrate dehydrogenase DT536_11840 ENOG4105CJ1 ABC, transporter DT536_11845 ENOG4107QWP ABC-2 type transporter DT536_11850 ENOG4107QWP ABC-2 type transporter DT536_11855 ENOG4105D3G Pseudouridine synthase DT536_11860 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) DT536_11875 ENOG4105EJ2 Transcriptional regulator DT536_11900 ENOG4107QS8 (LipO)protein DT536_11920 ENOG4105VEQ Cold shock protein DT536_11960 ENOG4105VEQ Cold shock protein DT536_11990 ENOG4105CNM Receptor DT536_12030 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DT536_12035 ENOG4105EA8 2-Nitropropane dioxygenase DT536_12060 ENOG4108JU3 Alkyl hydroperoxide reductase DT536_12080 ENOG4105CHM Aminotransferase DT536_12085 ENOG4105E0X reductase DT536_12090 ENOG4108V06 Glutathione peroxidase DT536_12115 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) DT536_12125 ENOG4105ZED uncharacterized protein ygaH DT536_12130 ENOG4108UMN azlc family DT536_12155 ENOG4105C3G gtp-binding protein DT536_12165 ENOG4108UMI ABC transporter, permease DT536_12170 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DT536_12175 ENOG4105D01 (LipO)protein DT536_12180 ENOG4105D01 (LipO)protein DT536_12190 ENOG4107T8P acyl-Coa dehydrogenase DT536_12195 ENOG4107T8P acyl-Coa dehydrogenase DT536_12220 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase DT536_12255 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DT536_12260 ENOG4107TSN permease DT536_12285 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DT536_12290 ENOG4105DDY UPF0142 protein ycaO DT536_12295 ENOG4105E7U AraC family transcriptional regulator DT536_12300 ENOG4105EEF Alkane 1-monooxygenase DT536_12305 ENOG4108Z66 YbaK ebsC protein DT536_12335 ENOG4105EYM Major Facilitator superfamily DT536_12350 ENOG41067MG lrgb family DT536_12355 ENOG4105VAW lrga family DT536_12360 ENOG4105CMU LysR family (Transcriptional regulator DT536_12390 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) DT536_12415 ENOG4105CMR udp-glucose 4-epimerase DT536_12510 ENOG4105NBK UPF0345 protein DT536_12530 ENOG4107RZC phospholipase d DT536_12540 ENOG4105BZU Histidine kinase DT536_12545 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DT536_12550 ENOG4105CZX twitching motility protein DT536_12555 ENOG4105CZM Major Facilitator DT536_12565 ENOG4108ZX5 transcriptional regulator DT536_12570 ENOG4105BZ1 (ABC) transporter DT536_12580 ENOG4105CUY Mechanosensitive ion channel DT536_12585 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme DT536_12605 ENOG41080HT Transcriptional regulator, arsr family DT536_12610 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DT536_12615 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) DT536_12620 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) DT536_12625 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) DT536_12630 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) DT536_12635 ENOG4105C2W permease DT536_12645 ENOG4105C6T cysteine synthase DT536_12650 ENOG41062JF Transcriptional regulator DT536_12655 ENOG4105CHU acetyl-coa acetyltransferase DT536_12660 ENOG4105G2Y Transcriptional regulator DT536_12675 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DT536_12685 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DT536_12690 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DT536_12710 ENOG4105NN7 muconolactone delta-isomerase DT536_12715 ENOG4105DTQ mandelate racemase muconate lactonizing DT536_12720 ENOG4108KB2 LysR family Transcriptional regulator DT536_12725 ENOG4105D2S major facilitator superfamily DT536_12830 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DT536_12835 ENOG4107R0V Pyruvate dehydrogenase DT536_12840 ENOG4105CPP Dehydrogenase, E1 component DT536_12845 ENOG4105C7S Dehydrogenase DT536_12855 ENOG4105CHR reductase DT536_12865 ENOG4105VYA Uncharacterized conserved protein (DUF2132) DT536_13025 ENOG4105EKQ RNA-directed DNA polymerase DT536_13040 ENOG4105HDD phospholipase DT536_13050 ENOG4105CSR polyphosphate kinase 2 DT536_13065 ENOG4105D0S secretion protein (HlyD DT536_13070 ENOG4105CJ1 ABC, transporter DT536_13075 ENOG4105CMI transporter DT536_13135 ENOG4105EKQ RNA-directed DNA polymerase DT536_13180 ENOG4107Y80 Major Facilitator superfamily DT536_13255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DT536_13260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DT536_13280 ENOG4108J1Q DT536_13365 ENOG4105CDV Ompa motb domain protein DT536_13420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DT536_13450 ENOG4105EV9 Alpha Beta Hydrolase DT536_13520 ENOG4105MRR Transcriptional regulator (By similarity) DT536_13540 ENOG4105CHR reductase DT536_13545 ENOG4105D8G Major Facilitator superfamily DT536_13555 ENOG4105BZU Histidine kinase DT536_13580 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DT536_13600 ENOG4105C1G acyl-Coa dehydrogenase DT536_13605 ENOG4105C1G acyl-Coa dehydrogenase DT536_13655 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DT536_13690 ENOG41080XP Cbs domain DT536_13695 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DT536_13720 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) DT536_13725 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DT536_13735 ENOG4105C28 cystathionine DT536_13765 ENOG4105K59 histidine triad (HIT) protein DT536_13790 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DT536_13795 ENOG4105K70 DNA-binding protein DT536_13810 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DT536_13820 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DT536_13825 ENOG4108Z4V iron-sulfur cluster assembly DT536_13840 ENOG4108ZIT Ferredoxin, 2FE-2S DT536_13845 ENOG4105F8J Adenylate Guanylate cyclase DT536_13855 ENOG4108JA2 transcriptioN-repair coupling factor DT536_13870 ENOG4105CK7 Sodium proline symporter DT536_13875 ENOG4105EW9 transcriptional regulator AsnC family DT536_13880 ENOG4105C26 Dehydrogenase DT536_13915 ENOG4105FFC UPF0187 protein DT536_13920 ENOG4105CX6 glutaminyL-tRNA synthetase DT536_13930 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) DT536_13940 ENOG4108RCM Nitroreductase DT536_13950 ENOG4108TZV Membrane DT536_13955 ENOG4105D2N Aldolase DT536_13965 ENOG4105BZA Phosphoglycerate kinase DT536_13975 ENOG4108UHJ MAF-like protein DT536_13985 ENOG4105EZE Cupin 4 family protein DT536_13990 ENOG4105BZU Histidine kinase DT536_13995 ENOG4105WH1 Two component transcriptional regulator luxr family DT536_14000 ENOG4105CBC glutamate synthase DT536_14020 ENOG4105KJF protein tyrosine phosphatase DT536_14025 ENOG4105C0A alcohol dehydrogenase DT536_14035 ENOG4107QMP dna polymerase iii subunits gamma and tau DT536_14055 ENOG4105CHR reductase DT536_14060 ENOG4105CHU acetyl-coa acetyltransferase DT536_14080 ENOG4105HEI LysR family (Transcriptional regulator DT536_14085 ENOG4107QV2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DT536_14090 ENOG4108NIW Leucine export protein LeuE DT536_14095 ENOG4105DKK Benzoate DT536_14100 ENOG4108Q5F Tetr family transcriptional regulator DT536_14105 ENOG410814C multidrug resistance protein DT536_14130 ENOG4105CD8 aminopeptidase N DT536_14155 ENOG4105EE5 Membrane protein terC DT536_14175 ENOG4107QP3 malate synthase g DT536_14180 ENOG4105D6Z AFG1 family ATPase DT536_14190 ENOG4107RN6 Monooxygenase DT536_14195 ENOG4105DWU Membrane DT536_14210 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DT536_14215 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DT536_14230 ENOG4108Z6B deaminase DT536_14240 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DT536_14250 ENOG4108RTD type II secretion system protein K DT536_14275 ENOG4105F8V Hydrolase, tatD family DT536_14285 ENOG4107QRG dna polymerase iii DT536_14295 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DT536_14300 ENOG4105BZ1 (ABC) transporter DT536_14315 ENOG4105FA0 parb-like partition protein DT536_14320 ENOG4107QJE Chromosome Partitioning Protein DT536_14330 ENOG4108S0S Nucleotidyl transferase DT536_14335 ENOG4105EHM Aminoglycoside phosphotransferase DT536_14340 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DT536_14345 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DT536_14350 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DT536_14360 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DT536_14365 ENOG4105K8N protein family UPF0079, ATPase DT536_14370 ENOG4105DR9 pseudouridine synthase DT536_14385 ENOG4105I08 Pseudouridine synthase DT536_14390 ENOG4108VMM UPF0756 membrane protein DT536_14395 ENOG4105F27 Major Facilitator DT536_14400 ENOG4105EYW Ion transport protein DT536_14405 ENOG4107QUV Domain protein DT536_14415 ENOG4105C0A alcohol dehydrogenase DT536_14425 ENOG4107RR1 TRANSCRIPTIONal DT536_14435 ENOG4105CUB amino acid DT536_14440 ENOG4105CPD ethanolamine ammonia-lyase DT536_14445 ENOG4107FQ9 ethanolamine ammonia-lyase DT536_14455 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DT536_14465 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DT536_14475 ENOG4108R6G acetyltransferase DT536_14485 ENOG4105CV1 Transketolase (EC 2.2.1.1) DT536_14490 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DT536_14535 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DT536_14575 ENOG4105JAB phenazine biosynthesis protein, phzf family DT536_14580 ENOG4108ETY sodium dicarboxylate symporter DT536_14585 ENOG4108MEJ flavin reductase domain protein DT536_14605 ENOG4105DFP Integrase DT536_14640 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DT536_14655 ENOG4108K4C ec 3.1.3.12 DT536_14660 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DT536_14665 ENOG4106UW1 Major Facilitator superfamily DT536_14710 ENOG4107VMU Membrane DT536_14725 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DT536_14730 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DT536_14745 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DT536_14835 ENOG4108R99 pseudouridine synthase DT536_14870 ENOG4105F8C transglutaminase domain-containing protein DT536_14880 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DT536_14885 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DT536_14890 ENOG4105VCD cytoplasmic protein DT536_14895 ENOG4105D22 carbon starvation protein DT536_14900 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DT536_14905 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DT536_14920 ENOG4105VFB Binds the 23S rRNA (By similarity) DT536_14925 ENOG4105DHU Bile acid DT536_14940 ENOG4105DAN ATP-dependent protease DT536_14945 ENOG4105M2J Glutaredoxin DT536_14950 ENOG4105C8Y Acetylornithine aminotransferase DT536_14955 ENOG4105ERU peptidase DT536_14960 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DT536_14970 ENOG4105C8U phosphate abc transporter DT536_14975 ENOG4105CVA phosphate DT536_14980 ENOG4105DY8 decarboxylase DT536_14985 ENOG4108JPW Aminotransferase DT536_15000 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DT536_15005 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DT536_15015 ENOG4105KVH Transcriptional regulator DT536_15020 ENOG4105ECR NmrA family DT536_15050 ENOG4105DTR rard protein DT536_15060 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DT536_15075 ENOG4105BZU Histidine kinase DT536_15085 ENOG4105CHM Aminotransferase DT536_15115 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase DT536_15120 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DT536_15125 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DT536_15135 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DT536_15140 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DT536_15150 ENOG4105C3F Signal peptidase i DT536_15180 ENOG4105C0H protease DT536_15185 ENOG4108IYU L-aspartate oxidase DT536_15200 ENOG4105HHA aminodeoxychorismate lyase DT536_15210 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DT536_15220 ENOG4108I5D sulfate abc transporter DT536_15230 ENOG4108IJ6 ABC transporter DT536_15235 ENOG4107R11 Transcriptional regulator DT536_15255 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DT536_15260 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DT536_15275 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DT536_15285 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DT536_15290 ENOG4108YYC ycei family DT536_15320 ENOG4105EGD dinuclear metal center protein, YbgI family DT536_15330 ENOG4108ETH Formylglycinamide ribotide synthetase DT536_15340 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DT536_15345 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DT536_15360 ENOG4107YD3 Thioesterase DT536_15365 ENOG4105E02 MotA TolQ exbB proton channel DT536_15370 ENOG4105M8F Biopolymer transport protein exbD tolR DT536_15380 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DT536_15385 ENOG4105KCK Peptidoglycan-associated lipoprotein DT536_15440 ENOG4105C02 permease DT536_15445 ENOG4105CXB phosphoribosylaminoimidazole synthetase DT536_15450 ENOG4108V3E phosphoribosylglycinamide formyltransferase DT536_15470 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DT536_15475 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DT536_15480 ENOG4105D60 lipoprotein releasing system transmembrane protein DT536_15490 ENOG4108594 Permease of the drug metabolite transporter DT536_15495 ENOG4108UPT UPF0178 protein DT536_15505 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DT536_15510 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DT536_15515 ENOG4107QPN acyl-Coa dehydrogenase DT536_15560 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) DT536_15565 ENOG4105SYT Methylenetetrahydrofolate reductase DT536_15570 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DT536_15575 ENOG4105BZU Histidine kinase DT536_15580 ENOG4105C6K Malic enzyme DT536_15590 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) DT536_15610 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DT536_15615 ENOG4105CXG d-lactate dehydrogenase DT536_15625 ENOG41073TP transcriptional regulator DT536_15630 ENOG4105DAA L-lactate DT536_15645 ENOG4105EKE dihydroorotase DT536_15650 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) DT536_15670 ENOG4108IQI permease DT536_15695 ENOG4107S01 Repressor protein MetJ DT536_15710 ENOG4108JQ5 ABC transporter DT536_15715 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component DT536_15720 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component DT536_15725 ENOG4105E43 Extracellular solute-binding protein, family 5 DT536_15730 ENOG4105E9H Lytic Murein transglycosylase DT536_15735 ENOG4107RZZ dna polymerase iii epsilon subunit DT536_15745 ENOG4105E09 nadh pyrophosphatase DT536_15755 ENOG4105W4M Transport-associated protein DT536_15765 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DT536_15770 ENOG4105EJC lysr family transcriptional regulator DT536_15775 ENOG4108K5P (LipO)protein DT536_15810 ENOG4105DZ1 carboxypeptidase DT536_15815 ENOG4108Z0R Transferase DT536_15820 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase DT536_15825 ENOG4105E8V Alpha Beta Hydrolase Fold protein DT536_15830 ENOG41077RS Phosphatase DT536_15845 ENOG4108HPI phosphatidate Cytidylyltransferase DT536_15860 ENOG41075W9 High frequency lysogenization protein HflD homolog DT536_15865 ENOG4107QTF adenylosuccinate lyase DT536_15880 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DT536_15885 ENOG4105D0A hydroxylase DT536_15900 ENOG4107RAQ aminopeptidase DT536_15935 ENOG4105M8F Biopolymer transport protein exbD tolR DT536_15940 ENOG4105E02 MotA TolQ exbB proton channel DT536_15955 ENOG4105BZU Histidine kinase DT536_15960 ENOG4108ZX5 transcriptional regulator DT536_15970 ENOG4105G6Z alkaline phosphatase DT536_15975 ENOG4105G6Z alkaline phosphatase DT536_15990 ENOG4108JIK carboxylase DT536_16010 ENOG4105C5A transporter DT536_16015 ENOG4108WAV Transcriptional regulator DT536_16020 ENOG4105C59 p-type ATPase DT536_16030 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DT536_16045 ENOG4107VAM peptidase, m28 DT536_16055 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DT536_16065 ENOG4105D82 Glutamate dehydrogenase DT536_16070 ENOG4108R3D Electron transport complex DT536_16080 ENOG4105CSM endonuclease III DT536_16105 ENOG4105CJN penicillin-binding protein DT536_16110 ENOG4106H78 methyltransferase DT536_16130 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase DT536_16155 ENOG4105DFG type I secretion outer membrane protein DT536_16170 ENOG4105UYK outer membrane protein a DT536_16220 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DT536_16225 ENOG4105CSH Transporter DT536_16280 ENOG4105NTW Transcriptional regulator DT536_16295 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DT536_16300 ENOG4105C11 sulfate adenylyltransferase), subunit 2 DT536_16315 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DT536_16320 ENOG4105VCQ rubredoxin DT536_16325 ENOG4107QZF nitrite reductase NADPH large subunit DT536_16335 ENOG4105C5Q Transcriptional regulator DT536_16350 ENOG4107U91 Rhomboid family DT536_16355 ENOG4105CV6 ABC transporter, permease DT536_16360 ENOG4108I0Y (ABC) transporter DT536_16365 ENOG4108UJV acyl-CoA thioesterase i DT536_16385 ENOG4107RNH Outer membrane receptor FepA DT536_16405 ENOG4105CJ3 phosphate transporter DT536_16410 ENOG4105C3R Methionine synthase DT536_16415 ENOG4105EU0 Major facilitator Superfamily DT536_16420 ENOG4105R1U AraC Family Transcriptional Regulator DT536_16425 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DT536_16430 ENOG4105CSH Transporter DT536_16445 ENOG4107XDY Nicotinamide Mononucleotide Transporter DT536_16475 ENOG4105BZU Histidine kinase DT536_16485 ENOG4108VWS Yaeq family DT536_16490 ENOG4105CKI cobalamin synthesis protein DT536_16505 ENOG4105D78 K07001 NTE family protein DT536_16515 ENOG4105BZG amino acid carrier protein DT536_16520 ENOG4105D6U Sodium Glutamate Symporter DT536_16530 ENOG4105C2C drug resistance transporter, Bcr CflA