locus-tag	class	description
RZ95_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RZ95_00010	COG0592	DNA-directed DNA polymerase activity
RZ95_00020	COG0187	DNA topoisomerase II activity
RZ95_00030	COG0488	(ABC) transporter
RZ95_00110	COG1943	Transposase
RZ95_00120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RZ95_00150	COG2814	Major facilitator Superfamily
RZ95_00160	COG0733	neurotransmitter:sodium symporter activity
RZ95_00180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RZ95_00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RZ95_00195	COG0129	dihydroxy-acid dehydratase activity
RZ95_00205	COG4774	siderophore transport
RZ95_00215	COG0583	DNA-binding transcription factor activity
RZ95_00220	COG2233	PERMEase
RZ95_00230	COG1309	transcriptional regulator
RZ95_00250	COG0484	heat shock protein binding
RZ95_00275	COG0436	Aminotransferase
RZ95_00280	COG1064	alcohol dehydrogenase
RZ95_00285	COG2818	Glycosylase
RZ95_00315	COG5487	UPF0391 membrane protein
RZ95_00320	COG2983	Belongs to the UPF0260 family
RZ95_00325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RZ95_00330	COG1943	Transposase
RZ95_00355	COG4160	amino acid transport
RZ95_00360	COG4215	(ABC) transporter
RZ95_00365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RZ95_00385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RZ95_00400	COG0385	Bile acid
RZ95_00430	COG3385	transposase activity
RZ95_00475	COG0534	Mate efflux family protein
RZ95_00480	COG0436	Aminotransferase
RZ95_00485	COG2733	membrane
RZ95_00500	COG2918	glutathione biosynthetic process
RZ95_00505	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RZ95_00515	COG3150	esterase
RZ95_00530	COG0559	Belongs to the binding-protein-dependent transport system permease family
RZ95_00545	COG0410	ABC transporter
RZ95_00595	COG3706	GGDEF domain
RZ95_00600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RZ95_00615	COG1393	Belongs to the ArsC family
RZ95_00620	COG0708	Exodeoxyribonuclease III
RZ95_00630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RZ95_00645	COG1846	Transcriptional regulator
RZ95_00650	COG0386	Belongs to the glutathione peroxidase family
RZ95_00655	COG0189	ligase activity
RZ95_00665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RZ95_00675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RZ95_00685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RZ95_00715	COG2119	membrane
RZ95_00720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RZ95_00720	COG0426	domain, Protein
RZ95_00745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RZ95_00770	COG1902	pentaerythritol trinitrate reductase activity
RZ95_00775	COG1519	Transferase
RZ95_00780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RZ95_00785	COG0668	transmembrane transport
RZ95_00790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RZ95_00795	COG0307	riboflavin synthase, alpha
RZ95_00800	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_00815	COG0431	NADPH-dependent FMN reductase
RZ95_00830	COG0784	Response regulator, receiver
RZ95_00830	COG2205	protein histidine kinase activity
RZ95_00835	COG3162	membrane
RZ95_00840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RZ95_00875	COG3706	GGDEF domain
RZ95_00895	COG0351	phosphomethylpyrimidine kinase
RZ95_00895	COG0352	thiamine-phosphate diphosphorylase activity
RZ95_00895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RZ95_00910	COG2814	Major facilitator Superfamily
RZ95_00915	COG0629	single-stranded DNA binding
RZ95_00940	COG2826	transposase and inactivated derivatives, IS30 family
RZ95_00945	COG2801	Transposase and inactivated derivatives
RZ95_00965	COG2132	Multicopper oxidase
RZ95_00980	COG2205	protein histidine kinase activity
RZ95_00985	COG3174	membrane
RZ95_00990	COG2217	Heavy metal translocating P-type atpase
RZ95_01030	COG3316	Transposase and inactivated derivatives
RZ95_01080	COG0583	DNA-binding transcription factor activity
RZ95_01085	COG1301	dicarboxylic acid transport
RZ95_01100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RZ95_01105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RZ95_01110	COG0450	alkyl hydroperoxide reductase
RZ95_01120	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RZ95_01195	COG0582	viral genome integration into host DNA
RZ95_01225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RZ95_01250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RZ95_01255	COG1278	Cold shock
RZ95_01270	COG0531	amino acid
RZ95_01275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RZ95_01305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RZ95_01340	COG0427	acetyl-CoA hydrolase
RZ95_01345	COG2205	protein histidine kinase activity
RZ95_01350	COG0745	RESPONSE REGULATOR receiver
RZ95_01370	COG4221	oxidoreductase activity
RZ95_01380	COG0488	(ABC) transporter
RZ95_01405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RZ95_01420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RZ95_01440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RZ95_01445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RZ95_01455	COG2226	methyltransferase
RZ95_01515	COG0067	glutamate synthase
RZ95_01515	COG0069	glutamate synthase activity
RZ95_01515	COG0070	glutamate synthase
RZ95_01520	COG0493	'glutamate synthase
RZ95_01530	COG1704	LemA family
RZ95_01535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RZ95_01560	COG4372	Transposase
RZ95_01590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RZ95_01595	COG1758	RNA polymerase activity
RZ95_01600	COG0194	GDP metabolic process
RZ95_01615	COG0228	four-way junction DNA binding
RZ95_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RZ95_01630	COG0335	large ribosomal subunit rRNA binding
RZ95_01645	COG3335	DDE superfamily endonuclease
RZ95_01660	COG5380	lipid catabolic process
RZ95_01665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RZ95_01680	COG5006	permease, DMT superfamily
RZ95_01685	COG5006	permease, DMT superfamily
RZ95_01690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RZ95_01695	COG0277	FAD linked oxidase domain protein
RZ95_01720	COG2814	Major facilitator Superfamily
RZ95_01725	COG1289	transmembrane transporter activity
RZ95_01730	COG2032	superoxide dismutase activity
RZ95_01735	COG0628	permease
RZ95_01740	COG1192	Involved in chromosome partitioning
RZ95_01750	COG2226	methyltransferase
RZ95_01765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RZ95_01770	COG0254	rRNA binding
RZ95_01775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RZ95_01785	COG0534	Mate efflux family protein
RZ95_01795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RZ95_01805	COG1960	acyl-CoA dehydrogenase activity
RZ95_01820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RZ95_01835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RZ95_01855	COG0513	Belongs to the DEAD box helicase family
RZ95_01860	COG1127	ABC transporter
RZ95_01865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RZ95_01870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RZ95_01875	COG2854	intermembrane phospholipid transfer
RZ95_01885	COG0598	Magnesium transport protein CorA
RZ95_01895	COG0494	nUDIX hydrolase
RZ95_01900	COG1040	competence protein
RZ95_01905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RZ95_01935	COG2937	Belongs to the GPAT DAPAT family
RZ95_01940	COG1946	Acyl-CoA thioesterase
RZ95_01945	COG1301	dicarboxylic acid transport
RZ95_01960	COG1959	2 iron, 2 sulfur cluster binding
RZ95_01965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RZ95_01965	COG1017	nitric oxide dioxygenase activity
RZ95_01970	COG0433	COG0433 Predicted ATPase
RZ95_01990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RZ95_01995	COG0088	Forms part of the polypeptide exit tunnel
RZ95_02010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RZ95_02015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RZ95_02060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RZ95_02065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RZ95_02075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RZ95_02095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RZ95_02100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RZ95_02105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RZ95_02115	COG0202	RNA polymerase activity
RZ95_02120	COG0203	ribosomal protein L17
RZ95_02125	COG2072	flavoprotein involved in K transport
RZ95_02135	COG1960	acyl-CoA dehydrogenase activity
RZ95_02140	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RZ95_02170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
RZ95_02175	COG0339	signal peptide processing
RZ95_02180	COG2720	vancomycin resistance protein
RZ95_02185	COG0557	exoribonuclease II activity
RZ95_02215	COG0179	Fumarylacetoacetate (FAA) hydrolase
RZ95_02230	COG1295	ribonuclease BN
RZ95_02245	COG3706	GGDEF domain
RZ95_02275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RZ95_02280	COG1702	phosphate starvation-inducible protein PhoH
RZ95_02285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RZ95_02290	COG1196	nuclear chromosome segregation
RZ95_02290	COG0741	lytic transglycosylase activity
RZ95_02290	COG0739	heme binding
RZ95_02300	COG0039	L-malate dehydrogenase activity
RZ95_02325	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RZ95_02330	COG1183	phosphatidylcholine synthase activity
RZ95_02375	COG3453	Protein conserved in bacteria
RZ95_02375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RZ95_02390	COG1607	acyl-coa hydrolase
RZ95_02405	COG1666	GTP binding
RZ95_02425	COG2350	Protein conserved in bacteria
RZ95_02435	COG0613	PHP domain protein
RZ95_02440	COG3781	membrane
RZ95_02450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RZ95_02475	COG1162	GTPase activity
RZ95_02480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RZ95_02515	COG1538	Outer membrane efflux protein
RZ95_02525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RZ95_02550	COG0028	Belongs to the TPP enzyme family
RZ95_02555	COG0440	acetolactate synthase activity
RZ95_02615	COG1426	Protein conserved in bacteria
RZ95_02635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RZ95_02660	COG1862	Preprotein translocase
RZ95_02675	COG0675	Transposase, IS605 OrfB family
RZ95_02685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RZ95_02695	COG0582	viral genome integration into host DNA
RZ95_02750	COG5002	protein histidine kinase activity
RZ95_02755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RZ95_02825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RZ95_02855	COG3223	Belongs to the PsiE family
RZ95_02860	COG1960	acyl-CoA dehydrogenase activity
RZ95_02865	COG1960	acyl-CoA dehydrogenase activity
RZ95_02875	COG2205	protein histidine kinase activity
RZ95_02880	COG0745	RESPONSE REGULATOR receiver
RZ95_02885	COG1113	amino acid transport
RZ95_02890	COG2315	Protein conserved in bacteria
RZ95_02895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RZ95_02915	COG2096	Adenosyltransferase
RZ95_02920	COG4206	TonB-dependent receptor
RZ95_02930	COG0133	tryptophan synthase activity
RZ95_02970	COG0285	dihydrofolate synthase activity
RZ95_02990	COG0450	alkyl hydroperoxide reductase
RZ95_03010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RZ95_03015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RZ95_03045	COG2199	diguanylate cyclase activity
RZ95_03100	COG4372	Transposase
RZ95_03120	COG2969	positive regulation of protein catabolic process
RZ95_03125	COG0625	glutathione transferase activity
RZ95_03135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RZ95_03140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RZ95_03150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RZ95_03155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RZ95_03180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RZ95_03190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RZ95_03195	COG1408	metallophosphoesterase
RZ95_03205	COG0477	Major facilitator Superfamily
RZ95_03210	COG1272	protein, Hemolysin III
RZ95_03230	COG1250	3-hydroxyacyl-CoA dehydrogenase
RZ95_03230	COG1024	Enoyl-CoA hydratase
RZ95_03235	COG0183	Belongs to the thiolase family
RZ95_03240	COG2207	Transcriptional regulator
RZ95_03245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RZ95_03260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RZ95_03280	COG0183	Belongs to the thiolase family
RZ95_03290	COG2885	chlorophyll binding
RZ95_03290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RZ95_03295	COG0833	amino acid
RZ95_03300	COG2813	Specifically methylates the guanine in position
RZ95_03305	COG2233	PERMEase
RZ95_03315	COG1970	mechanosensitive ion channel activity
RZ95_03325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RZ95_03335	COG3659	wide pore channel activity
RZ95_03340	COG1902	pentaerythritol trinitrate reductase activity
RZ95_03370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RZ95_03385	COG4456	Virulence-associated protein
RZ95_03420	COG0346	lactoylglutathione lyase activity
RZ95_03425	COG0564	pseudouridine synthase activity
RZ95_03445	COG3189	MarR family transcriptional regulator
RZ95_03450	COG2824	Alkylphosphonate utilization operon protein PhnA
RZ95_03460	COG3422	double-strand break repair
RZ95_03500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RZ95_03520	COG0730	response to heat
RZ95_03530	COG1196	nuclear chromosome segregation
RZ95_03535	COG3115	cell septum assembly
RZ95_03540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RZ95_03545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RZ95_03570	COG2193	ferroxidase activity
RZ95_03575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RZ95_03580	COG2267	carboxylic ester hydrolase activity
RZ95_03595	COG4106	trans-aconitate 2-methyltransferase activity
RZ95_03665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RZ95_03670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RZ95_03680	COG0009	L-threonylcarbamoyladenylate synthase
RZ95_03685	COG3101	peptidyl-lysine hydroxylation
RZ95_03690	COG1399	metal-binding, possibly nucleic acid-binding protein
RZ95_03695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RZ95_03705	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_03715	COG1652	LysM domain
RZ95_03720	COG1802	Transcriptional regulator
RZ95_03725	COG0439	Biotin carboxylase
RZ95_03735	COG3501	Rhs element vgr protein
RZ95_03755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RZ95_03765	COG0745	RESPONSE REGULATOR receiver
RZ95_03770	COG2205	protein histidine kinase activity
RZ95_03780	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RZ95_03800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RZ95_03815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RZ95_03825	COG0713	ATP synthesis coupled electron transport
RZ95_03830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RZ95_03835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RZ95_03845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RZ95_03850	COG1278	Cold shock
RZ95_03855	COG1278	Cold shock
RZ95_03860	COG0583	DNA-binding transcription factor activity
RZ95_03870	COG0745	RESPONSE REGULATOR receiver
RZ95_03870	COG3706	GGDEF domain
RZ95_03895	COG0525	valine-tRNA ligase activity
RZ95_03905	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_03925	COG2433	Pfam Transposase IS66
RZ95_03930	COG4372	Transposase
RZ95_03940	COG0393	Putative heavy-metal-binding
RZ95_03945	COG1538	Outer membrane efflux protein
RZ95_03955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RZ95_03960	COG0671	phosphoesterase, PA-phosphatase related
RZ95_03980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RZ95_03995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RZ95_04005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RZ95_04010	COG1648	precorrin-2 dehydrogenase activity
RZ95_04010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RZ95_04015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RZ95_04035	COG0531	amino acid
RZ95_04050	COG0321	lipoyl(octanoyl) transferase activity
RZ95_04055	COG2921	Belongs to the UPF0250 family
RZ95_04075	COG1280	lysine exporter protein (LysE YggA)
RZ95_04090	COG0586	Pfam SNARE associated Golgi protein
RZ95_04115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RZ95_04140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RZ95_04145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RZ95_04175	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RZ95_04190	COG0358	DNA primase activity
RZ95_04200	COG0564	pseudouridine synthase activity
RZ95_04225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RZ95_04240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RZ95_04240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RZ95_04260	COG2072	flavoprotein involved in K transport
RZ95_04270	COG2009	succinate dehydrogenase
RZ95_04275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RZ95_04280	COG1053	succinate dehydrogenase
RZ95_04285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RZ95_04300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RZ95_04310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RZ95_04320	COG2268	Band 7 protein
RZ95_04325	COG1585	Membrane protein implicated in regulation of membrane protease activity
RZ95_04335	COG2354	Protein conserved in bacteria
RZ95_04340	COG2321	neutral zinc metallopeptidase
RZ95_04355	COG3695	enzyme binding
RZ95_04380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RZ95_04385	COG0505	Belongs to the CarA family
RZ95_04410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RZ95_04415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RZ95_04455	COG2851	Citrate transporter
RZ95_04460	COG1253	flavin adenine dinucleotide binding
RZ95_04490	COG2239	Acts as a magnesium transporter
RZ95_04505	COG0501	Belongs to the peptidase M48B family
RZ95_04510	COG0741	lytic transglycosylase activity
RZ95_04515	COG0037	tRNA processing
RZ95_04530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RZ95_04550	COG0697	spore germination
RZ95_04560	COG1309	transcriptional regulator
RZ95_04575	COG1741	Belongs to the pirin family
RZ95_04595	COG3739	integral membrane protein
RZ95_04610	COG3706	GGDEF domain
RZ95_04620	COG0302	gtp cyclohydrolase
RZ95_04630	COG0134	indole-3-glycerol-phosphate synthase activity
RZ95_04635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RZ95_04640	COG0512	Glutamine amidotransferase of anthranilate synthase
RZ95_04655	COG3161	chorismate lyase activity
RZ95_04660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RZ95_04700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RZ95_04710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RZ95_04715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RZ95_04730	COG1115	amino acid carrier protein
RZ95_04735	COG1113	amino acid transport
RZ95_04745	COG0019	diaminopimelate decarboxylase activity
RZ95_04755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RZ95_04765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RZ95_04770	COG1522	sequence-specific DNA binding
RZ95_04775	COG1280	lysine exporter protein (LysE YggA)
RZ95_04810	COG0842	Transport permease protein
RZ95_04815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RZ95_04830	COG2175	clavaminate synthase activity
RZ95_04850	COG0024	Methionine aminopeptidase
RZ95_04855	COG0052	Belongs to the universal ribosomal protein uS2 family
RZ95_04880	COG4372	Transposase
RZ95_04910	COG4372	Transposase
RZ95_04920	COG2951	lytic endotransglycosylase activity
RZ95_04940	COG0842	Transport permease protein
RZ95_04945	COG1131	(ABC) transporter
RZ95_04955	COG0303	'Molybdopterin
RZ95_04960	COG0521	Mo-molybdopterin cofactor biosynthetic process
RZ95_04960	COG0315	cyclic pyranopterin monophosphate synthase activity
RZ95_04965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RZ95_04970	COG0243	molybdopterin cofactor binding
RZ95_04975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RZ95_04985	COG0725	ABC transporter, periplasmic molybdate-binding protein
RZ95_04990	COG4149	molybdate abc transporter
RZ95_05020	COG2169	Transcriptional regulator
RZ95_05025	COG0235	Class ii aldolase
RZ95_05030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RZ95_05035	COG0697	spore germination
RZ95_05040	COG0475	glutathione-regulated potassium exporter activity
RZ95_05040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RZ95_05045	COG3706	GGDEF domain
RZ95_05085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RZ95_05105	COG3634	alkyl hydroperoxide reductase activity
RZ95_05110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RZ95_05130	COG3501	Rhs element vgr protein
RZ95_05170	COG1720	tRNA m6t6A37 methyltransferase activity
RZ95_05180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RZ95_05195	COG0642	Histidine kinase
RZ95_05200	COG0494	nUDIX hydrolase
RZ95_05210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RZ95_05215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RZ95_05220	COG3139	Protein of unknown function (DUF1315)
RZ95_05235	COG1301	dicarboxylic acid transport
RZ95_05245	COG1960	acyl-CoA dehydrogenase activity
RZ95_05250	COG0693	protein deglycase activity
RZ95_05260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RZ95_05265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RZ95_05295	COG0415	Belongs to the DNA photolyase family
RZ95_05305	COG2252	PERMEase
RZ95_05310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RZ95_05320	COG3038	cytochrome b561
RZ95_05335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RZ95_05345	COG0527	aspartate kinase activity
RZ95_05355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RZ95_05370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RZ95_05375	COG1522	sequence-specific DNA binding
RZ95_05400	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RZ95_05415	COG0667	Aldo Keto reductase
RZ95_05425	COG1765	OsmC-like protein
RZ95_05450	COG0540	Belongs to the ATCase OTCase family
RZ95_05470	COG2031	fatty acid transporter
RZ95_05475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RZ95_05500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RZ95_05505	COG1960	acyl-CoA dehydrogenase activity
RZ95_05510	COG1309	transcriptional regulator
RZ95_05515	COG0318	PFAM AMP-dependent synthetase and ligase
RZ95_05545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RZ95_05555	COG0659	secondary active sulfate transmembrane transporter activity
RZ95_05560	COG0625	glutathione transferase activity
RZ95_05565	COG2249	NAD(P)H dehydrogenase (quinone) activity
RZ95_05590	COG2363	Small membrane protein
RZ95_05605	COG1278	Cold shock
RZ95_05610	COG0513	Belongs to the DEAD box helicase family
RZ95_05620	COG0778	Nitroreductase
RZ95_05645	COG0167	dihydroorotate dehydrogenase activity
RZ95_05675	COG4783	chaperone-mediated protein folding
RZ95_05680	COG1610	YqeY-like protein
RZ95_05685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RZ95_05710	COG2815	serine threonine protein kinase
RZ95_05710	COG0515	serine threonine protein kinase
RZ95_05735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RZ95_05740	COG0450	alkyl hydroperoxide reductase
RZ95_05745	COG1643	Atp-dependent helicase
RZ95_05765	COG1116	anion transmembrane transporter activity
RZ95_05765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RZ95_05775	COG2223	nitrite transmembrane transporter activity
RZ95_05780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RZ95_05785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RZ95_05790	COG0243	molybdopterin cofactor binding
RZ95_05800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RZ95_05835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RZ95_05840	COG0406	alpha-ribazole phosphatase activity
RZ95_05850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RZ95_05850	COG0517	IMP dehydrogenase activity
RZ95_05855	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RZ95_05865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RZ95_05870	COG1137	ATPase activity
RZ95_05900	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RZ95_05940	COG2011	ABC-type metal ion transport system permease component
RZ95_05945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RZ95_05955	COG0151	Belongs to the GarS family
RZ95_05960	COG0138	bifunctional purine biosynthesis protein purh
RZ95_05965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RZ95_05995	COG0445	tRNA wobble uridine modification
RZ95_06010	COG2308	Evidence 4 Homologs of previously reported genes of
RZ95_06020	COG1305	Transglutaminase-like
RZ95_06035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RZ95_06040	COG0305	Participates in initiation and elongation during chromosome replication
RZ95_06055	COG0360	Binds together with S18 to 16S ribosomal RNA
RZ95_06075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RZ95_06080	COG1845	cytochrome c oxidase, subunit III
RZ95_06085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RZ95_06090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RZ95_06120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RZ95_06135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RZ95_06140	COG2890	protein-(glutamine-N5) methyltransferase activity
RZ95_06145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RZ95_06150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RZ95_06180	COG1960	acyl-CoA dehydrogenase activity
RZ95_06185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RZ95_06200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RZ95_06225	COG0729	surface antigen
RZ95_06270	COG0786	glutamate:sodium symporter activity
RZ95_06280	COG1113	amino acid transport
RZ95_06305	COG0024	Methionine aminopeptidase
RZ95_06310	COG0583	DNA-binding transcription factor activity
RZ95_06315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RZ95_06330	COG3852	Histidine kinase
RZ95_06350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RZ95_06355	COG0575	Belongs to the CDS family
RZ95_06370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RZ95_06390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RZ95_06400	COG2137	regulation of response to DNA damage stimulus
RZ95_06405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RZ95_06410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RZ95_06415	COG1011	Hydrolase
RZ95_06445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RZ95_06645	COG1218	3'(2'),5'-bisphosphate nucleotidase
RZ95_06670	COG0702	epimerase
RZ95_06675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RZ95_06695	COG0446	pyridine nucleotide-disulphide oxidoreductase
RZ95_06695	COG1902	pentaerythritol trinitrate reductase activity
RZ95_06710	COG2814	Major facilitator Superfamily
RZ95_06730	COG0583	DNA-binding transcription factor activity
RZ95_06750	COG0148	phosphopyruvate hydratase activity
RZ95_06765	COG0772	Belongs to the SEDS family
RZ95_06780	COG0579	oxidoreductase
RZ95_06790	COG1012	belongs to the aldehyde dehydrogenase family
RZ95_06795	COG1309	transcriptional regulator
RZ95_06800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RZ95_06815	COG4890	Cyd operon protein YbgT
RZ95_06820	COG1294	oxidase, subunit
RZ95_06835	COG1585	Membrane protein implicated in regulation of membrane protease activity
RZ95_06845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RZ95_06865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RZ95_06870	COG0569	domain protein
RZ95_06880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RZ95_06885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RZ95_06920	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RZ95_06925	COG0542	response to heat
RZ95_06955	COG0372	Belongs to the citrate synthase family
RZ95_06965	COG2819	hydrolase of the alpha beta superfamily
RZ95_06970	COG0318	PFAM AMP-dependent synthetase and ligase
RZ95_06995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RZ95_06995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RZ95_07000	COG1254	Belongs to the acylphosphatase family
RZ95_07005	COG1047	Peptidyl-prolyl cis-trans
RZ95_07010	COG1252	NADH dehydrogenase
RZ95_07015	COG1686	Belongs to the peptidase S11 family
RZ95_07025	COG2351	hydroxyisourate hydrolase activity
RZ95_07075	COG1335	isochorismatase
RZ95_07095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RZ95_07110	COG2323	membrane
RZ95_07150	COG2223	nitrite transmembrane transporter activity
RZ95_07155	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RZ95_07160	COG1877	trehalose-phosphatase activity
RZ95_07170	COG1570	exodeoxyribonuclease VII activity
RZ95_07220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RZ95_07235	COG0612	Peptidase, M16
RZ95_07270	COG0352	thiamine-phosphate diphosphorylase activity
RZ95_07335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RZ95_07340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RZ95_07355	COG0456	acetyltransferase
RZ95_07360	COG2353	YceI-like domain
RZ95_07365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RZ95_07365	COG0519	Catalyzes the synthesis of GMP from XMP
RZ95_07375	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_07385	COG4302	ethanolamine ammonia-lyase activity
RZ95_07390	COG4303	Ethanolamine ammonia lyase large subunit
RZ95_07395	COG0531	amino acid
RZ95_07420	COG1454	alcohol dehydrogenase
RZ95_07430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RZ95_07435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RZ95_07440	COG2814	Major facilitator Superfamily
RZ95_07445	COG2707	UPF0756 membrane protein
RZ95_07450	COG1187	pseudouridine synthase activity
RZ95_07465	COG0564	pseudouridine synthase activity
RZ95_07470	COG0802	atpase or kinase
RZ95_07475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RZ95_07485	COG1923	regulation of RNA biosynthetic process
RZ95_07490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RZ95_07500	COG3178	'Phosphotransferase
RZ95_07505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RZ95_07515	COG1192	Involved in chromosome partitioning
RZ95_07520	COG1475	DNA binding
RZ95_07525	COG0811	peptide transport
RZ95_07535	COG1132	(ABC) transporter
RZ95_07540	COG1663	tetraacyldisaccharide 4'-kinase activity
RZ95_07560	COG0084	hydrolase, TatD family'
RZ95_07595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RZ95_07605	COG0590	tRNA wobble adenosine to inosine editing
RZ95_07625	COG0776	regulation of translation
RZ95_07640	COG2431	L-lysine efflux transmembrane transporter activity
RZ95_07655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RZ95_07660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RZ95_07680	COG1253	flavin adenine dinucleotide binding
RZ95_07705	COG0308	aminopeptidase N
RZ95_07715	COG0589	response to stress
RZ95_07730	COG2076	Multidrug Resistance protein
RZ95_07735	COG1309	transcriptional regulator
RZ95_07740	COG3135	benzoate transporter
RZ95_07750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RZ95_07755	COG0583	DNA-binding transcription factor activity
RZ95_07770	COG0183	Belongs to the thiolase family
RZ95_07775	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_07795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RZ95_07800	COG0824	Thioesterase
RZ95_07805	COG1454	alcohol dehydrogenase
RZ95_07810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RZ95_07830	COG0069	glutamate synthase activity
RZ95_07835	COG2197	response regulator
RZ95_07845	COG2850	peptidyl-arginine hydroxylation
RZ95_07855	COG0424	maF-like protein
RZ95_07865	COG0126	phosphoglycerate kinase activity
RZ95_07880	COG0697	spore germination
RZ95_07900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RZ95_07910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RZ95_07915	COG3781	membrane
RZ95_07960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RZ95_07970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RZ95_08000	COG0316	Belongs to the HesB IscA family
RZ95_08005	COG0822	iron-sulfur transferase activity
RZ95_08015	COG1959	2 iron, 2 sulfur cluster binding
RZ95_08030	COG0776	regulation of translation
RZ95_08035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RZ95_08060	COG0537	adenosine 5'-monophosphoramidase activity
RZ95_08095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RZ95_08110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RZ95_08125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RZ95_08135	COG0133	tryptophan synthase activity
RZ95_08140	COG0516	GMP reductase activity
RZ95_08140	COG0517	IMP dehydrogenase activity
RZ95_08170	COG0612	Peptidase, M16
RZ95_08175	COG0552	protein localization to endoplasmic reticulum
RZ95_08225	COG1960	acyl-CoA dehydrogenase activity
RZ95_08230	COG1960	acyl-CoA dehydrogenase activity
RZ95_08275	COG2199	diguanylate cyclase activity
RZ95_08285	COG2814	Major facilitator Superfamily
RZ95_08290	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_08315	COG0864	Transcriptional regulator
RZ95_08385	COG0596	Alpha beta hydrolase
RZ95_08425	COG3293	Transposase
RZ95_08540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RZ95_08600	COG2814	Major facilitator Superfamily
RZ95_08640	COG1253	flavin adenine dinucleotide binding
RZ95_08650	COG0604	alcohol dehydrogenase
RZ95_08655	COG1309	transcriptional regulator
RZ95_08715	COG1063	alcohol dehydrogenase
RZ95_08725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RZ95_08730	COG0508	dehydrogenase complex catalyzes the overall conversion of
RZ95_08735	COG0022	dehydrogenase e1 component
RZ95_08740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RZ95_08745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RZ95_08755	COG0745	RESPONSE REGULATOR receiver
RZ95_08760	COG5002	protein histidine kinase activity
RZ95_08770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RZ95_08775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RZ95_08785	COG0583	DNA-binding transcription factor activity
RZ95_08875	COG2814	Major facilitator Superfamily
RZ95_08880	COG0583	DNA-binding transcription factor activity
RZ95_08885	COG4948	Mandelate Racemase Muconate Lactonizing
RZ95_08890	COG4829	muconolactone delta-isomerase
RZ95_08900	COG4638	Rieske (2fe-2S)
RZ95_08905	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
RZ95_08910	COG0633	Ferredoxin
RZ95_08910	COG0543	2 iron, 2 sulfur cluster binding
RZ95_08915	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_08920	COG3135	benzoate transporter
RZ95_08925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RZ95_08930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RZ95_08935	COG0183	Belongs to the thiolase family
RZ95_08940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RZ95_08955	COG0511	ligase activity, forming carbon-carbon bonds
RZ95_08970	COG0439	Biotin carboxylase
RZ95_08985	COG0583	DNA-binding transcription factor activity
RZ95_08990	COG0183	Belongs to the thiolase family
RZ95_09000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RZ95_09010	COG2233	PERMEase
RZ95_09015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RZ95_09020	COG0251	oxidation-reduction process
RZ95_09025	COG1335	isochorismatase
RZ95_09030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RZ95_09035	COG0596	Alpha beta hydrolase
RZ95_09040	COG0640	Transcriptional regulator
RZ95_09060	COG3122	Protein conserved in bacteria
RZ95_09065	COG0668	transmembrane transport
RZ95_09075	COG1132	(ABC) transporter
RZ95_09100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RZ95_09105	COG5001	Diguanylate cyclase
RZ95_09105	COG3300	MHYT domain
RZ95_09120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RZ95_09125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RZ95_09145	COG3123	guanosine phosphorylase activity
RZ95_09195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RZ95_09240	COG3293	Transposase
RZ95_09330	COG3561	AntA/AntB antirepressor
RZ95_09405	COG5410	chromosome segregation
RZ95_09420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RZ95_09585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RZ95_09590	COG0583	DNA-binding transcription factor activity
RZ95_09595	COG1380	Effector of murein hydrolase LrgA
RZ95_09600	COG1346	cytolysis
RZ95_09615	COG2223	nitrite transmembrane transporter activity
RZ95_09645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RZ95_09650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RZ95_09655	COG2207	Transcriptional regulator
RZ95_09660	COG1944	ATP diphosphatase activity
RZ95_09665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RZ95_09685	COG0730	response to heat
RZ95_09690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RZ95_09710	COG1546	Belongs to the CinA family
RZ95_09710	COG1058	Belongs to the CinA family
RZ95_09735	COG0204	Acyl-transferase
RZ95_09775	COG1464	Belongs to the NlpA lipoprotein family
RZ95_09785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RZ95_09790	COG2011	ABC-type metal ion transport system permease component
RZ95_09795	COG0012	GTP binding
RZ95_09820	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RZ95_09835	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RZ95_09860	COG0386	Belongs to the glutathione peroxidase family
RZ95_09865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RZ95_09870	COG0436	Aminotransferase
RZ95_09890	COG3634	alkyl hydroperoxide reductase activity
RZ95_09915	COG2070	2-Nitropropane dioxygenase
RZ95_09925	COG3038	cytochrome b561
RZ95_09930	COG3706	GGDEF domain
RZ95_09930	COG0745	RESPONSE REGULATOR receiver
RZ95_09945	COG1278	Cold shock
RZ95_09955	COG0604	alcohol dehydrogenase
RZ95_09960	COG1733	regulation of RNA biosynthetic process
RZ95_10020	COG1309	transcriptional regulator
RZ95_10045	COG0842	Transport permease protein
RZ95_10050	COG0842	Transport permease protein
RZ95_10055	COG1131	(ABC) transporter
RZ95_10100	COG0697	spore germination
RZ95_10115	COG1538	Outer membrane efflux protein
RZ95_10120	COG0463	Glycosyl transferase, family 2
RZ95_10120	COG0457	Tetratricopeptide repeat
RZ95_10150	COG1126	abc transporter atp-binding protein
RZ95_10175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RZ95_10195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RZ95_10200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RZ95_10235	COG4695	Portal protein
RZ95_10450	COG0714	Associated with various cellular activities
RZ95_10460	COG2879	small protein
RZ95_10465	COG1966	Carbon starvation protein
RZ95_10470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RZ95_10475	COG1509	lysine 2,3-aminomutase activity
RZ95_10490	COG0254	rRNA binding
RZ95_10510	COG1067	ATP-dependent peptidase activity
RZ95_10515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RZ95_10520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RZ95_10525	COG0616	signal peptide processing
RZ95_10530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RZ95_10540	COG0573	inorganic phosphate transmembrane transporter activity
RZ95_10545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RZ95_10550	COG0076	glutamate decarboxylase activity
RZ95_10555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RZ95_10570	COG0671	phosphoesterase, PA-phosphatase related
RZ95_10575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RZ95_10585	COG1733	regulation of RNA biosynthetic process
RZ95_10590	COG0702	epimerase
RZ95_10620	COG0556	nucleotide-excision repair
RZ95_10645	COG3293	Transposase
RZ95_10685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RZ95_10690	COG1381	Involved in DNA repair and RecF pathway recombination
RZ95_10700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RZ95_10715	COG0681	Belongs to the peptidase S26 family
RZ95_10750	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RZ95_10760	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RZ95_10775	COG4208	sulfate ABC transporter
RZ95_10780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RZ95_10785	COG0583	DNA-binding transcription factor activity
RZ95_10805	COG0602	queuosine metabolic process
RZ95_10810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RZ95_10825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RZ95_10835	COG0583	DNA-binding transcription factor activity
RZ95_10840	COG2353	YceI-like domain
RZ95_10845	COG1051	belongs to the nudix hydrolase family
RZ95_10845	COG1056	cytidyltransferase-related domain
RZ95_10850	COG1024	Enoyl-CoA hydratase
RZ95_10860	COG3323	Protein of unknown function (DUF1653)
RZ95_10860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RZ95_10870	COG0047	phosphoribosylformylglycinamidine synthase activity
RZ95_10870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RZ95_10890	COG0632	four-way junction helicase activity
RZ95_10895	COG2255	four-way junction helicase activity
RZ95_10910	COG0824	Thioesterase
RZ95_10930	COG0823	Involved in the tonB-independent uptake of proteins
RZ95_10950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RZ95_10980	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RZ95_10985	COG0628	permease
RZ95_10990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RZ95_10995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RZ95_11015	COG2333	competence protein COMEC
RZ95_11015	COG0658	competence protein
RZ95_11020	COG1136	(ABC) transporter
RZ95_11035	COG0697	spore germination
RZ95_11040	COG1671	Belongs to the UPF0178 family
RZ95_11050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RZ95_11055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RZ95_11100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RZ95_11105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RZ95_11110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RZ95_11115	COG5001	Diguanylate cyclase
RZ95_11115	COG1716	ATPase activity
RZ95_11120	COG0280	phosphate acetyltransferase
RZ95_11120	COG0281	malic enzyme
RZ95_11155	COG0446	pyridine nucleotide-disulphide oxidoreductase
RZ95_11155	COG1902	pentaerythritol trinitrate reductase activity
RZ95_11160	COG0277	FAD linked oxidase domain protein
RZ95_11170	COG2186	Transcriptional regulator
RZ95_11185	COG2203	Gaf domain
RZ95_11185	COG3706	GGDEF domain
RZ95_11185	COG4251	negative regulation of phosphorylation
RZ95_11185	COG5001	Diguanylate cyclase
RZ95_11190	COG0418	dihydroorotase activity
RZ95_11195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RZ95_11205	COG0833	amino acid
RZ95_11215	COG0833	amino acid
RZ95_11240	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
RZ95_11255	COG4172	Belongs to the ABC transporter superfamily
RZ95_11260	COG4239	(ABC) transporter, permease
RZ95_11265	COG4174	ABC transporter (Permease)
RZ95_11270	COG4166	transmembrane transport
RZ95_11275	COG0741	lytic transglycosylase activity
RZ95_11275	COG1388	LysM domain
RZ95_11280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RZ95_11290	COG2816	NAD+ diphosphatase activity
RZ95_11315	COG0583	DNA-binding transcription factor activity
RZ95_11320	COG1388	LysM domain
RZ95_11320	COG4942	peptidase
RZ95_11335	COG0753	catalase activity
RZ95_11365	COG1686	Belongs to the peptidase S11 family
RZ95_11370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RZ95_11385	COG2915	High frequency lysogenization protein hflD homolog
RZ95_11405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RZ95_11410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RZ95_11425	COG0006	proline dipeptidase activity
RZ95_11485	COG0745	RESPONSE REGULATOR receiver
RZ95_11485	COG3706	GGDEF domain
RZ95_11500	COG1785	Belongs to the alkaline phosphatase family
RZ95_11530	COG4770	biotin carboxylase activity
RZ95_11550	COG1914	H( )-stimulated, divalent metal cation uptake system
RZ95_11555	COG0583	DNA-binding transcription factor activity
RZ95_11560	COG2217	Heavy metal translocating P-type atpase
RZ95_11570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RZ95_11585	COG2234	aminopeptidase activity
RZ95_11595	COG3384	dioxygenase
RZ95_11605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RZ95_11610	COG2878	Part of a membrane complex involved in electron transport
RZ95_11615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RZ95_11640	COG0768	penicillin binding
RZ95_11645	COG0742	ribosomal rna small subunit methyltransferase
RZ95_11660	COG0204	Acyl-transferase
RZ95_11670	COG3119	arylsulfatase activity
RZ95_11675	COG0641	radical SAM
RZ95_11715	COG0477	Major facilitator Superfamily
RZ95_11730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RZ95_11770	COG1695	Transcriptional regulator
RZ95_11790	COG0175	sulfate reduction
RZ95_11815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RZ95_11820	COG1773	rubredoxin
RZ95_11825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RZ95_11835	COG0583	DNA-binding transcription factor activity
RZ95_11855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RZ95_11860	COG4181	ATPase activity
RZ95_11885	COG4771	TonB-dependent receptor
RZ95_11910	COG0306	phosphate transporter
RZ95_11930	COG2852	Protein conserved in bacteria
RZ95_11940	COG2223	nitrite transmembrane transporter activity
RZ95_11945	COG2207	Transcriptional regulator
RZ95_11950	COG0242	peptide deformylase activity
RZ95_11955	COG0477	Major facilitator Superfamily
RZ95_11995	COG0456	acetyltransferase
RZ95_12010	COG4681	YaeQ
RZ95_12015	COG0523	cobalamin synthesis protein
RZ95_12030	COG1607	acyl-coa hydrolase
RZ95_12035	COG1752	Esterase of the alpha-beta hydrolase superfamily
RZ95_12045	COG1115	amino acid carrier protein
RZ95_12050	COG0786	glutamate:sodium symporter activity
RZ95_12070	COG2814	Major facilitator Superfamily
RZ95_12075	COG1289	transmembrane transporter activity
RZ95_12085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RZ95_12145	COG2832	Protein of unknown function (DUF454)
RZ95_12160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RZ95_12170	COG2198	Histidine kinase
RZ95_12170	COG0643	Histidine kinase
RZ95_12170	COG0643	Histidine kinase
RZ95_12170	COG2198	Histidine kinase
RZ95_12175	COG0840	transmembrane signaling receptor activity
RZ95_12270	COG0489	protein tyrosine kinase activity
RZ95_12295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RZ95_12295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RZ95_12330	COG4716	Myosin-crossreactive antigen
RZ95_12360	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RZ95_12365	COG2081	HI0933 family
RZ95_12375	COG0668	transmembrane transport
RZ95_12395	COG0765	amino acid transport
RZ95_12400	COG0765	amino acid transport
RZ95_12405	COG1126	abc transporter atp-binding protein
RZ95_12415	COG0004	ammonium transporteR
RZ95_12430	COG0642	Histidine kinase
RZ95_12435	COG0745	RESPONSE REGULATOR receiver
RZ95_12470	COG1752	Esterase of the alpha-beta hydrolase superfamily
RZ95_12485	COG0142	geranyltranstransferase activity
RZ95_12490	COG2828	Protein conserved in bacteria
RZ95_12495	COG1113	amino acid transport
RZ95_12510	COG1113	amino acid transport
RZ95_12515	COG1448	Aminotransferase
RZ95_12530	COG0625	glutathione transferase activity
RZ95_12540	COG2072	flavoprotein involved in K transport
RZ95_12545	COG0431	NADPH-dependent FMN reductase
RZ95_12550	COG0798	PFAM Bile acid sodium symporter
RZ95_12560	COG0640	Transcriptional regulator
RZ95_12605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RZ95_12610	COG1530	ribonuclease E activity
RZ95_12615	COG0424	maF-like protein
RZ95_12620	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RZ95_12625	COG1792	Involved in formation and maintenance of cell shape
RZ95_12635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RZ95_12645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RZ95_12685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RZ95_12695	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_12700	COG2610	gluconate transmembrane transporter activity
RZ95_12705	COG0583	DNA-binding transcription factor activity
RZ95_12715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RZ95_12725	COG4772	TonB-dependent receptor
RZ95_12730	COG4993	Dehydrogenase
RZ95_12735	COG3659	wide pore channel activity
RZ95_12740	COG3420	alginic acid biosynthetic process
RZ95_12745	COG0710	3-dehydroquinate dehydratase activity
RZ95_12750	COG3485	protocatechuate 3,4-dioxygenase
RZ95_12755	COG3485	protocatechuate 3,4-dioxygenase
RZ95_12760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RZ95_12765	COG2271	Major facilitator Superfamily
RZ95_12770	COG0596	Alpha beta hydrolase
RZ95_12775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RZ95_12780	COG0183	Belongs to the thiolase family
RZ95_12785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RZ95_12790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
RZ95_12795	COG1414	Transcriptional regulator
RZ95_12805	COG1113	amino acid transport
RZ95_12815	COG3724	N-succinylarginine dihydrolase activity
RZ95_12820	COG1012	belongs to the aldehyde dehydrogenase family
RZ95_12825	COG3138	arginine N-succinyltransferase
RZ95_12835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RZ95_12840	COG1522	sequence-specific DNA binding
RZ95_12855	COG1012	belongs to the aldehyde dehydrogenase family
RZ95_12860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RZ95_12885	COG1271	oxidase subunit
RZ95_12890	COG1294	oxidase, subunit
RZ95_12895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RZ95_12905	COG1346	cytolysis
RZ95_12930	COG1522	sequence-specific DNA binding
RZ95_12945	COG2814	Major facilitator Superfamily
RZ95_13010	COG2130	NADP-dependent
RZ95_13015	COG1309	transcriptional regulator
RZ95_13025	COG1902	pentaerythritol trinitrate reductase activity
RZ95_13035	COG1979	alcohol dehydrogenase
RZ95_13045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RZ95_13060	COG3321	synthase
RZ95_13060	COG0604	alcohol dehydrogenase
RZ95_13065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RZ95_13070	COG0583	DNA-binding transcription factor activity
RZ95_13075	COG4221	oxidoreductase activity
RZ95_13095	COG3177	Filamentation induced by cAMP protein fic
RZ95_13105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RZ95_13140	COG0642	Histidine kinase
RZ95_13155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RZ95_13180	COG2816	NAD+ diphosphatase activity
RZ95_13185	COG3046	protein related to deoxyribodipyrimidine photolyase
RZ95_13260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RZ95_13265	COG2814	Major facilitator Superfamily
RZ95_13270	COG1566	PFAM secretion protein HlyD family protein
RZ95_13275	COG2050	protein possibly involved in aromatic compounds catabolism
RZ95_13290	COG1090	epimerase
RZ95_13300	COG5001	Diguanylate cyclase
RZ95_13300	COG2203	Gaf domain
RZ95_13300	COG3706	GGDEF domain
RZ95_13300	COG4251	negative regulation of phosphorylation
RZ95_13305	COG0420	3'-5' exonuclease activity
RZ95_13335	COG0735	belongs to the Fur family
RZ95_13340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RZ95_13345	COG2914	Belongs to the UPF0125 (RnfH) family
RZ95_13360	COG2826	transposase and inactivated derivatives, IS30 family
RZ95_13365	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RZ95_13375	COG2826	transposase and inactivated derivatives, IS30 family
RZ95_13380	COG0121	glutamine amidotransferase
RZ95_13395	COG0756	dUTP diphosphatase activity
RZ95_13400	COG0210	DNA helicase
RZ95_13405	COG2885	chlorophyll binding
RZ95_13410	COG0204	Acyl-transferase
RZ95_13420	COG0850	regulation of cytokinetic process
RZ95_13430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RZ95_13445	COG1674	ftsk spoiiie
RZ95_13445	COG0531	amino acid
RZ95_13450	COG0492	ferredoxin-NADP+ reductase activity
RZ95_13455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RZ95_13465	COG0456	acetyltransferase
RZ95_13490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RZ95_13515	COG1113	amino acid transport
RZ95_13520	COG0251	oxidation-reduction process
RZ95_13535	COG1522	sequence-specific DNA binding
RZ95_13550	COG0352	thiamine-phosphate diphosphorylase activity
RZ95_13550	COG0351	phosphomethylpyrimidine kinase
RZ95_13550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RZ95_13560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RZ95_13565	COG2076	Multidrug Resistance protein
RZ95_13570	COG2076	Multidrug Resistance protein
RZ95_13585	COG2132	Multicopper oxidase
RZ95_13595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RZ95_13630	COG1968	undecaprenyl-diphosphatase activity
RZ95_13635	COG1214	PFAM Peptidase M22, glycoprotease
RZ95_13640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RZ95_13645	COG0494	nUDIX hydrolase
RZ95_13695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RZ95_13705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RZ95_13730	COG0693	protein deglycase activity
RZ95_13750	COG2814	Major facilitator Superfamily
RZ95_13780	COG2853	Lipoprotein
RZ95_13785	COG2208	phosphoserine phosphatase activity
RZ95_13795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RZ95_13800	COG1764	response to oxidative stress
RZ95_13830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RZ95_13830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RZ95_13845	COG0037	tRNA processing
RZ95_13880	COG0072	phenylalanine-tRNA ligase activity
RZ95_13905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RZ95_13925	COG1238	metal cluster binding
RZ95_13940	COG0625	glutathione transferase activity
RZ95_13950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RZ95_13960	COG0318	PFAM AMP-dependent synthetase and ligase
RZ95_13965	COG3028	Belongs to the UPF0307 family
RZ95_13975	COG1660	Displays ATPase and GTPase activities
RZ95_13980	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RZ95_13990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RZ95_13995	COG0617	tRNA 3'-terminal CCA addition
RZ95_14000	COG1555	photosystem II stabilization
RZ95_14005	COG3956	TIGRFAM MazG family protein
RZ95_14015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RZ95_14030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RZ95_14035	COG2205	protein histidine kinase activity
RZ95_14035	COG5002	protein histidine kinase activity
RZ95_14035	COG0784	Response regulator, receiver
RZ95_14040	COG1024	Enoyl-CoA hydratase
RZ95_14045	COG2084	Dehydrogenase
RZ95_14050	COG3622	Belongs to the hyi family
RZ95_14065	COG0004	ammonium transporteR
RZ95_14075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RZ95_14080	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RZ95_14085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RZ95_14090	COG2814	Major facilitator Superfamily
RZ95_14110	COG0174	glutamine synthetase
RZ95_14115	COG0745	RESPONSE REGULATOR receiver
RZ95_14120	COG2205	protein histidine kinase activity
RZ95_14130	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RZ95_14135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RZ95_14165	COG1271	oxidase subunit
RZ95_14170	COG1294	oxidase, subunit
RZ95_14195	COG0492	ferredoxin-NADP+ reductase activity
RZ95_14200	COG0431	NADPH-dependent FMN reductase
RZ95_14205	COG0798	PFAM Bile acid sodium symporter
RZ95_14215	COG0640	Transcriptional regulator
RZ95_14245	COG4372	Transposase
RZ95_14340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RZ95_14365	COG0084	hydrolase, TatD family'
RZ95_14380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RZ95_14390	COG0793	Belongs to the peptidase S41A family
RZ95_14405	COG2267	carboxylic ester hydrolase activity
RZ95_14415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RZ95_14420	COG0857	belongs to the CobB CobQ family
RZ95_14420	COG0280	phosphate acetyltransferase
RZ95_14440	COG2207	Transcriptional regulator
RZ95_14440	COG3708	Transcriptional regulator
RZ95_14450	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RZ95_14450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RZ95_14470	COG0740	serine-type endopeptidase activity
RZ95_14485	COG4771	TonB-dependent receptor
RZ95_14490	COG4774	siderophore transport
RZ95_14505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RZ95_14510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RZ95_14515	COG2813	Specifically methylates the guanine in position
RZ95_14515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RZ95_14625	COG0788	formyltetrahydrofolate deformylase activity
RZ95_14640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RZ95_14645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RZ95_14650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RZ95_14650	COG4651	solute:proton antiporter activity
RZ95_14675	COG0210	DNA helicase
RZ95_14680	COG1929	Belongs to the glycerate kinase type-1 family
RZ95_14725	COG2900	Belongs to the SlyX family
RZ95_14740	COG1560	Kdo2-lipid A biosynthetic process
RZ95_14780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RZ95_14795	COG0473	3-isopropylmalate dehydrogenase activity
RZ95_14810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RZ95_14820	COG0583	DNA-binding transcription factor activity
RZ95_14870	COG1960	acyl-CoA dehydrogenase activity
RZ95_14885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RZ95_14900	COG0583	DNA-binding transcription factor activity
RZ95_14915	COG0564	pseudouridine synthase activity
RZ95_14920	COG1530	ribonuclease E activity
RZ95_14925	COG0318	PFAM AMP-dependent synthetase and ligase
RZ95_14950	COG1983	PspC domain protein
RZ95_14970	COG0751	glycine-tRNA ligase activity
RZ95_14975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RZ95_15010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RZ95_15025	COG2226	methyltransferase
RZ95_15050	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RZ95_15060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RZ95_15065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RZ95_15075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RZ95_15085	COG0644	oxidoreductase
RZ95_15085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RZ95_15095	COG0425	Belongs to the sulfur carrier protein TusA family
RZ95_15100	COG4535	Mg2 and Co2 transporter CorC
RZ95_15105	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RZ95_15110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RZ95_15130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RZ95_15140	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RZ95_15160	COG2841	Protein conserved in bacteria
RZ95_15165	COG0598	Magnesium transport protein CorA
RZ95_15170	COG1185	polyribonucleotide nucleotidyltransferase activity
RZ95_15185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RZ95_15195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RZ95_15225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RZ95_15240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RZ95_15250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RZ95_15255	COG2111	Na H antiporter
RZ95_15255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RZ95_15260	COG1006	Multisubunit Na H antiporter MnhC subunit
RZ95_15265	COG0651	ATP synthesis coupled electron transport
RZ95_15275	COG2212	antiporter activity
RZ95_15285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RZ95_15295	COG0195	Participates in both transcription termination and antitermination
RZ95_15355	COG0237	dephospho-CoA kinase activity
RZ95_15365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RZ95_15370	COG3123	guanosine phosphorylase activity
RZ95_15375	COG0497	DNA recombination
RZ95_15385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RZ95_15400	COG1289	transmembrane transporter activity
RZ95_15415	COG1132	(ABC) transporter
RZ95_15420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RZ95_15495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RZ95_15520	COG0326	Molecular chaperone. Has ATPase activity
RZ95_15530	COG3047	cAMP biosynthetic process
RZ95_15535	COG2056	Na+-H+ antiporter family
RZ95_15560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RZ95_15565	COG0085	RNA polymerase activity
RZ95_15570	COG0222	ribosome binding
RZ95_15575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RZ95_15580	COG0081	regulation of translation
RZ95_15585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RZ95_15635	COG0546	phosphoglycolate phosphatase activity
RZ95_15665	COG0824	Thioesterase
RZ95_15685	COG0181	hydroxymethylbilane synthase activity
RZ95_15695	COG3275	phosphorelay sensor kinase activity
RZ95_15715	COG1538	Outer membrane efflux protein
RZ95_15725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RZ95_15735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RZ95_15740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RZ95_15745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RZ95_15750	COG0772	Belongs to the SEDS family
RZ95_15755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RZ95_15775	COG4974	Belongs to the 'phage' integrase family
RZ95_15780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RZ95_15790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RZ95_15795	COG1686	Belongs to the peptidase S11 family
RZ95_15800	COG2197	response regulator
RZ95_15815	COG0793	Belongs to the peptidase S41A family
RZ95_15820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RZ95_15825	COG0795	lipopolysaccharide-transporting ATPase activity
RZ95_15830	COG0795	lipopolysaccharide-transporting ATPase activity
RZ95_15850	COG0586	Pfam SNARE associated Golgi protein
RZ95_15865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RZ95_15865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RZ95_15875	COG0004	ammonium transporteR
RZ95_15880	COG0347	Belongs to the P(II) protein family
RZ95_15945	COG0640	Transcriptional regulator
RZ95_16025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RZ95_16040	COG0318	PFAM AMP-dependent synthetase and ligase
RZ95_16055	COG0477	Major facilitator Superfamily
RZ95_16060	COG2860	membrane
RZ95_16065	COG3012	SEC-C Motif Domain Protein
RZ95_16070	COG1253	flavin adenine dinucleotide binding
RZ95_16100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RZ95_16175	COG0758	DNA mediated transformation
RZ95_16185	COG0697	spore germination
RZ95_16195	COG0386	Belongs to the glutathione peroxidase family
RZ95_16230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RZ95_16240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RZ95_16280	COG1121	(ABC) transporter
RZ95_16285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RZ95_16300	COG2837	iron assimilation
RZ95_16315	COG0791	NLP P60 protein
RZ95_16315	COG1388	LysM domain
RZ95_16320	COG3501	Rhs element vgr protein
RZ95_16325	COG0281	malic enzyme
RZ95_16375	COG0519	Catalyzes the synthesis of GMP from XMP
RZ95_16375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RZ95_16390	COG0586	Pfam SNARE associated Golgi protein
RZ95_16405	COG1192	Involved in chromosome partitioning
RZ95_16415	COG0271	Belongs to the BolA IbaG family
RZ95_16460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RZ95_16465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RZ95_16465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RZ95_16465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RZ95_16470	COG1105	Belongs to the carbohydrate kinase PfkB family
RZ95_16475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RZ95_16475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RZ95_16480	COG0583	DNA-binding transcription factor activity
RZ95_16485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RZ95_16500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RZ95_16510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RZ95_16515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RZ95_16525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RZ95_16530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RZ95_16540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RZ95_16555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RZ95_16560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RZ95_16570	COG0438	transferase activity, transferring glycosyl groups
RZ95_16580	COG0438	transferase activity, transferring glycosyl groups
RZ95_16605	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RZ95_16610	COG1088	dTDP-glucose 4,6-dehydratase activity
RZ95_16620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RZ95_16630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RZ95_16635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RZ95_16640	COG0438	transferase activity, transferring glycosyl groups
RZ95_16645	COG0438	transferase activity, transferring glycosyl groups
RZ95_16650	COG0438	transferase activity, transferring glycosyl groups
RZ95_16675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RZ95_16705	COG0728	peptidoglycan biosynthetic process
RZ95_16710	COG3023	N-Acetylmuramoyl-L-alanine amidase
RZ95_16720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RZ95_16730	COG3307	-O-antigen
RZ95_16735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RZ95_16740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RZ95_16745	COG0546	phosphoglycolate phosphatase activity
RZ95_16750	COG1028	Short-chain dehydrogenase reductase Sdr
RZ95_16770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RZ95_16770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RZ95_16775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RZ95_16780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RZ95_16785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RZ95_16790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RZ95_16795	COG1116	anion transmembrane transporter activity
RZ95_16800	COG1309	transcriptional regulator
RZ95_16815	COG0196	riboflavin kinase activity
RZ95_16820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RZ95_16825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RZ95_16830	COG1047	Peptidyl-prolyl cis-trans
RZ95_16890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RZ95_16895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RZ95_16900	COG2951	lytic endotransglycosylase activity
RZ95_16905	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RZ95_16920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RZ95_16950	COG0861	Integral membrane protein TerC family
RZ95_16960	COG0754	glutathionylspermidine amidase activity
RZ95_16970	COG0402	S-adenosylhomocysteine deaminase activity
RZ95_16990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RZ95_16995	COG1230	cation diffusion facilitator family transporter
RZ95_17015	COG0706	membrane insertase activity
RZ95_17020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RZ95_17030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RZ95_17045	COG0659	secondary active sulfate transmembrane transporter activity
RZ95_17050	COG2801	Transposase and inactivated derivatives
RZ95_17055	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RZ95_17060	COG3657	addiction module killer protein
RZ95_17075	COG3316	Transposase and inactivated derivatives
RZ95_17110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RZ95_17255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RZ95_17275	COG4783	chaperone-mediated protein folding
RZ95_17505	COG1192	Involved in chromosome partitioning
RZ95_17510	COG1475	DNA binding
RZ95_17700	COG2009	succinate dehydrogenase
RZ95_17715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RZ95_17725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RZ95_17765	COG0625	glutathione transferase activity
RZ95_17770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RZ95_17800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RZ95_17820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RZ95_17875	COG1132	(ABC) transporter
RZ95_17950	COG2826	transposase and inactivated derivatives, IS30 family
RZ95_17960	COG2826	transposase and inactivated derivatives, IS30 family
RZ95_18130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RZ95_18185	COG1525	nuclease
RZ95_18235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RZ95_18250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RZ95_18255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RZ95_18270	COG0183	Belongs to the thiolase family
RZ95_18275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RZ95_18280	COG3706	GGDEF domain
RZ95_18340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RZ95_18360	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RZ95_18365	COG3421	Type III restriction
RZ95_18400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RZ95_18495	COG0860	N-Acetylmuramoyl-L-alanine amidase
RZ95_18520	COG1660	Displays ATPase and GTPase activities
RZ95_18600	COG0179	Fumarylacetoacetate (FAA) hydrolase
RZ95_18605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RZ95_18610	COG4569	acetaldehyde dehydrogenase (acetylating) activity
RZ95_18615	COG3971	2-oxopent-4-enoate hydratase activity
RZ95_18685	COG3316	Transposase and inactivated derivatives
RZ95_18720	COG0789	Transcriptional regulator
RZ95_18745	COG0789	Transcriptional regulator
RZ95_18795	COG3316	Transposase and inactivated derivatives
RZ95_18810	COG0210	DNA helicase
RZ95_18830	COG0583	DNA-binding transcription factor activity
RZ95_18835	COG2814	Major facilitator Superfamily
RZ95_18865	COG1012	belongs to the aldehyde dehydrogenase family
RZ95_18875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RZ95_18880	COG3316	Transposase and inactivated derivatives
RZ95_18890	COG3316	Transposase and inactivated derivatives
RZ95_18895	COG5002	protein histidine kinase activity
RZ95_18905	COG1538	Outer membrane efflux protein
RZ95_18910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RZ95_18920	COG0745	RESPONSE REGULATOR receiver
RZ95_18925	COG2205	protein histidine kinase activity
RZ95_18940	COG3173	Aminoglycoside phosphotransferase
RZ95_19010	COG2826	transposase and inactivated derivatives, IS30 family
RZ95_19035	COG3121	Chaperone
RZ95_19040	COG3188	usher protein
RZ95_19065	COG2801	Transposase and inactivated derivatives
RZ95_19085	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RZ95_19090	COG3657	addiction module killer protein
RZ95_19155	COG2801	Transposase and inactivated derivatives
RZ95_19255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RZ95_19280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RZ95_19285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RZ95_19310	COG3077	Addiction module antitoxin, RelB DinJ family
RZ95_19350	COG1335	isochorismatase
RZ95_19355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RZ95_19365	COG3077	Addiction module antitoxin, RelB DinJ family
RZ95_19445	COG0589	response to stress
RZ95_19450	COG0659	secondary active sulfate transmembrane transporter activity
RZ95_19530	COG1192	Involved in chromosome partitioning
RZ95_19555	COG1373	ATPase (AAA superfamily
RZ95_19615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RZ95_19625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RZ95_19635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RZ95_19680	COG2814	Major facilitator Superfamily
RZ95_19685	COG0583	DNA-binding transcription factor activity
RZ95_19780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RZ95_19785	COG1414	Transcriptional regulator
RZ95_19875	COG2801	Transposase and inactivated derivatives
RZ95_19895	COG3293	Transposase
RZ95_19900	COG0210	DNA helicase
RZ95_19950	COG0582	viral genome integration into host DNA
RZ95_19955	COG2369	cell adhesion
RZ95_19965	COG3676	manually curated
RZ95_19985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RZ95_19990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII